ETV5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)6.17280542
2regulation of gene silencing by miRNA (GO:0060964)6.17280542
3regulation of gene silencing by RNA (GO:0060966)6.17280542
4nuclear pore organization (GO:0006999)4.65416519
5paraxial mesoderm development (GO:0048339)4.51613962
6nuclear pore complex assembly (GO:0051292)4.34030114
7DNA unwinding involved in DNA replication (GO:0006268)4.33279911
8positive regulation of SMAD protein import into nucleus (GO:0060391)4.26493366
9establishment of apical/basal cell polarity (GO:0035089)4.11116517
10pre-miRNA processing (GO:0031054)4.02655952
11heterochromatin organization (GO:0070828)3.95709293
12regulation of hippo signaling (GO:0035330)3.87480330
13DNA replication-dependent nucleosome organization (GO:0034723)3.86741631
14DNA replication-dependent nucleosome assembly (GO:0006335)3.86741631
15IMP biosynthetic process (GO:0006188)3.86374223
16histone arginine methylation (GO:0034969)3.85802190
17anterior/posterior axis specification, embryo (GO:0008595)3.84859492
18protein localization to kinetochore (GO:0034501)3.84841884
19peptidyl-arginine omega-N-methylation (GO:0035247)3.83371777
20mitotic sister chromatid segregation (GO:0000070)3.80452623
21determination of adult lifespan (GO:0008340)3.80102368
22regulation of translational termination (GO:0006449)3.76439661
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.69818477
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69818477
25negative regulation of histone methylation (GO:0031061)3.68479471
26regulation of translational fidelity (GO:0006450)3.64795838
27establishment or maintenance of monopolar cell polarity (GO:0061339)3.64154178
28establishment of monopolar cell polarity (GO:0061162)3.64154178
29mitotic nuclear envelope disassembly (GO:0007077)3.60593535
30regulation of helicase activity (GO:0051095)3.56775579
31melanin biosynthetic process (GO:0042438)3.55315476
32regulation of SMAD protein import into nucleus (GO:0060390)3.54445786
33sister chromatid segregation (GO:0000819)3.50387219
34regulation of histone H3-K9 methylation (GO:0051570)3.49341451
35DNA replication initiation (GO:0006270)3.49177740
36establishment of integrated proviral latency (GO:0075713)3.46194035
37histone H4-K12 acetylation (GO:0043983)3.44431709
38regulation of sister chromatid cohesion (GO:0007063)3.42196918
39peptidyl-arginine N-methylation (GO:0035246)3.42077926
40peptidyl-arginine methylation (GO:0018216)3.42077926
41membrane disassembly (GO:0030397)3.41828383
42nuclear envelope disassembly (GO:0051081)3.41828383
43presynaptic membrane assembly (GO:0097105)3.41808757
44polarized epithelial cell differentiation (GO:0030859)3.39576686
45mitotic metaphase plate congression (GO:0007080)3.36834755
46folic acid-containing compound biosynthetic process (GO:0009396)3.35014398
47mitotic chromosome condensation (GO:0007076)3.33249580
48nucleobase biosynthetic process (GO:0046112)3.33104818
49regulation of gene silencing (GO:0060968)3.29023512
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28704429
51DNA geometric change (GO:0032392)3.27808288
52ventricular cardiac muscle cell development (GO:0055015)3.27697434
53DNA duplex unwinding (GO:0032508)3.27024443
54mitotic G1 DNA damage checkpoint (GO:0031571)3.26724645
55pore complex assembly (GO:0046931)3.26468924
56IMP metabolic process (GO:0046040)3.22712423
57mitotic cytokinesis (GO:0000281)3.17723025
58formation of translation preinitiation complex (GO:0001731)3.14572351
59regulation of mitotic spindle organization (GO:0060236)3.13859083
60nodal signaling pathway (GO:0038092)3.13228723
61mitotic sister chromatid cohesion (GO:0007064)3.11376969
62regulation of spindle organization (GO:0090224)3.03779965
63negative regulation of gene silencing (GO:0060969)3.02084239
64histone H4-K5 acetylation (GO:0043981)3.01905934
65histone H4-K8 acetylation (GO:0043982)3.01905934
66protein localization to chromosome, centromeric region (GO:0071459)3.01863588
67secondary metabolite biosynthetic process (GO:0044550)2.99492301
68lung-associated mesenchyme development (GO:0060484)2.98835147
69melanin metabolic process (GO:0006582)2.93437506
70ribosome biogenesis (GO:0042254)2.91683214
71cytoskeleton-dependent cytokinesis (GO:0061640)2.88303773
72chondrocyte proliferation (GO:0035988)2.87977849
73metaphase plate congression (GO:0051310)2.87297705
74regulation of nuclear cell cycle DNA replication (GO:0033262)2.86183119
75spliceosomal tri-snRNP complex assembly (GO:0000244)2.84109504
76ribosome assembly (GO:0042255)2.83719400
77regulation of centriole replication (GO:0046599)2.83131443
78retina vasculature morphogenesis in camera-type eye (GO:0061299)2.82206597
79C4-dicarboxylate transport (GO:0015740)2.82193798
80purine nucleobase biosynthetic process (GO:0009113)2.80780274
81postsynaptic membrane organization (GO:0001941)2.79623914
82embryonic process involved in female pregnancy (GO:0060136)2.78485653
83protein complex localization (GO:0031503)2.78408071
84regulation of centrosome cycle (GO:0046605)2.77117291
85positive regulation of chromosome segregation (GO:0051984)2.76782440
86negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.76705332
87DNA strand elongation involved in DNA replication (GO:0006271)2.76654191
88regulation of chromosome segregation (GO:0051983)2.74845160
89presynaptic membrane organization (GO:0097090)2.74705782
90chromatin assembly (GO:0031497)2.74671288
91regulation of telomere maintenance via telomerase (GO:0032210)2.73703674
92notochord development (GO:0030903)2.72805613
93mitotic G1/S transition checkpoint (GO:0044819)2.70111124
94negative regulation of chromosome segregation (GO:0051985)2.69758278
95chaperone-mediated protein complex assembly (GO:0051131)2.69629928
96negative regulation of chondrocyte differentiation (GO:0032331)2.68117856
97cell adhesion mediated by integrin (GO:0033627)2.67281069
98protein K6-linked ubiquitination (GO:0085020)2.65224133
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64529356
100cerebral cortex radially oriented cell migration (GO:0021799)2.64449323
101G1 DNA damage checkpoint (GO:0044783)2.64202472
102protein heterotetramerization (GO:0051290)2.62721623
103trophectodermal cell differentiation (GO:0001829)2.61175295
104oligodendrocyte differentiation (GO:0048709)2.61068835
105DNA strand elongation (GO:0022616)2.56156167
106negative regulation of chromatin modification (GO:1903309)2.55765054
107L-serine metabolic process (GO:0006563)2.55004281
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.54227436
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.54227436
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.54227436
111negative regulation of sister chromatid segregation (GO:0033046)2.54227436
112nuclear envelope organization (GO:0006998)2.53466595
113mRNA transport (GO:0051028)2.53219854
114cell migration involved in gastrulation (GO:0042074)2.52834317
115establishment of chromosome localization (GO:0051303)2.51585453
116negative regulation of histone modification (GO:0031057)2.50767740
117spindle assembly checkpoint (GO:0071173)2.50674364
118postreplication repair (GO:0006301)2.49581094
119mitotic spindle assembly checkpoint (GO:0007094)2.49058232
120mitotic spindle checkpoint (GO:0071174)2.47823735
121dosage compensation (GO:0007549)2.47621850
122barbed-end actin filament capping (GO:0051016)2.47466480
123positive regulation of neuroblast proliferation (GO:0002052)2.46408364
124establishment of viral latency (GO:0019043)2.45174965
125cerebral cortex cell migration (GO:0021795)2.45065280
126kinetochore organization (GO:0051383)2.43648496
127membrane assembly (GO:0071709)2.42665083
128mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.41305324
129regulation of DNA endoreduplication (GO:0032875)2.40987701
130hippo signaling (GO:0035329)2.38535244
131ganglion development (GO:0061548)2.38318260
132spindle checkpoint (GO:0031577)2.36607864
133amino acid import (GO:0043090)2.35064304
134DNA topological change (GO:0006265)2.31280581
135dorsal/ventral axis specification (GO:0009950)2.30796296
136cellular potassium ion homeostasis (GO:0030007)2.27558273
137lung vasculature development (GO:0060426)2.25102679
138establishment of spindle localization (GO:0051293)2.23800006
139positive regulation of male gonad development (GO:2000020)2.23495721
140fibroblast migration (GO:0010761)2.22914551
141positive regulation of mitotic sister chromatid separation (GO:1901970)2.20949546
142positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.20949546
143positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.20949546
144non-recombinational repair (GO:0000726)2.19374643
145double-strand break repair via nonhomologous end joining (GO:0006303)2.19374643
146cerebellar Purkinje cell layer development (GO:0021680)2.19221583
147radial glial cell differentiation (GO:0060019)2.19039209
148regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.17257530
149long-chain fatty acid biosynthetic process (GO:0042759)2.16467507
150chromosome condensation (GO:0030261)2.16304397
151positive regulation of DNA-dependent DNA replication (GO:2000105)2.14940476
152skin morphogenesis (GO:0043589)2.10308554
153regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.08608113
154positive regulation of dendritic spine morphogenesis (GO:0061003)2.08454833
155UDP-N-acetylglucosamine metabolic process (GO:0006047)2.05999137
156resolution of meiotic recombination intermediates (GO:0000712)2.05515619
157regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.05456326
158regulation of mitotic metaphase/anaphase transition (GO:0030071)2.05456326
159generation of neurons (GO:0048699)2.04776582
160layer formation in cerebral cortex (GO:0021819)2.04747469
161dermatan sulfate biosynthetic process (GO:0030208)2.04063644
162sodium ion export (GO:0071436)2.03582456
163neuron projection extension involved in neuron projection guidance (GO:1902284)2.03178145
164axon extension involved in axon guidance (GO:0048846)2.03178145
165response to X-ray (GO:0010165)2.03005926
166G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.02260751
167craniofacial suture morphogenesis (GO:0097094)2.02071149
168meiotic chromosome segregation (GO:0045132)2.01539068
169regulation of non-canonical Wnt signaling pathway (GO:2000050)2.01260004
170chromatin remodeling at centromere (GO:0031055)2.01170670
171lipopolysaccharide biosynthetic process (GO:0009103)2.01089290
172CENP-A containing nucleosome assembly (GO:0034080)1.98187730
173regulation of meiosis I (GO:0060631)1.97613637
174cell migration involved in sprouting angiogenesis (GO:0002042)1.97611190
175Notch signaling involved in heart development (GO:0061314)1.97009522
176regulation of mitotic sister chromatid segregation (GO:0033047)1.96376426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.63126523
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.16466852
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.74035052
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.74035052
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.74035052
6* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.48576185
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.38719513
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.32292187
9* NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.02746897
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02237664
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.94544424
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.89453593
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.83339215
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82670151
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.78405087
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.71207122
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.68541848
18* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.65546410
19* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.53055419
20* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.51924899
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.42574682
22* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.37150900
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35444624
24* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30496340
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29688038
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26395372
27SOX2_18555785_ChIP-Seq_MESCs_Mouse2.23180470
28ESR1_15608294_ChIP-ChIP_MCF-7_Human2.23012639
29* WT1_19549856_ChIP-ChIP_CCG9911_Human2.21766237
30* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.10578864
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08328220
32* EGR1_19374776_ChIP-ChIP_THP-1_Human2.08065171
33STAT3_1855785_ChIP-Seq_MESCs_Mouse2.02680172
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.97347379
35* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.96404953
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95734572
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95381556
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95371349
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94107660
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88308388
41* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83430590
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77268388
43* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75589839
44* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.72773899
45* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.72516484
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70328481
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69794318
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.68911949
49AR_21909140_ChIP-Seq_LNCAP_Human1.65072593
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64618558
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62688822
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.62518606
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62380059
54GBX2_23144817_ChIP-Seq_PC3_Human1.62164234
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60225683
56* BRD4_25478319_ChIP-Seq_HGPS_Human1.59923400
57CLOCK_20551151_ChIP-Seq_293T_Human1.58649395
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57274894
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56983959
60* SOX9_26525672_Chip-Seq_HEART_Mouse1.56772965
61XRN2_22483619_ChIP-Seq_HELA_Human1.55416678
62* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.54258364
63SOX2_18692474_ChIP-Seq_MEFs_Mouse1.53755714
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52449879
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.49582302
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49374497
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48961375
68* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.47182810
69* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.45900457
70CJUN_26792858_Chip-Seq_BT549_Human1.44743477
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44470727
72ELK1_19687146_ChIP-ChIP_HELA_Human1.43213805
73NANOG_18692474_ChIP-Seq_MEFs_Mouse1.41091808
74* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40451833
75OCT4_18692474_ChIP-Seq_MEFs_Mouse1.40208230
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39286616
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38726247
78* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36997224
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33373446
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.32256759
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31322018
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30695789
83* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29182976
84AR_21572438_ChIP-Seq_LNCaP_Human1.28351304
85* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28127391
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27979705
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27593358
88* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.26751888
89ZNF263_19887448_ChIP-Seq_K562_Human1.26490413
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25372676
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25317602
92P300_19829295_ChIP-Seq_ESCs_Human1.25049426
93* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24240239
94MYC_22102868_ChIP-Seq_BL_Human1.24205517
95* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23152035
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23093981
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23016621
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23003872
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.22384495
100CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22137939
101TP53_16413492_ChIP-PET_HCT116_Human1.21299012
102TP53_18474530_ChIP-ChIP_U2OS_Human1.20856797
103* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20779952
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20112065
105ETS1_20019798_ChIP-Seq_JURKAT_Human1.19074510
106* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16820475
107* NANOG_16518401_ChIP-PET_MESCs_Mouse1.16789858
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16753192
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15500555
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14251727
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13998431
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13934252
113HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12871748
114* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11169957
115* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11141638
116TTF2_22483619_ChIP-Seq_HELA_Human1.11027023
117* SMAD3_21741376_ChIP-Seq_EPCs_Human1.10880164
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10190515
119NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09455316
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09455316
121* SMAD4_21799915_ChIP-Seq_A2780_Human1.09307764
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08463393
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.07447981
124CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06707071
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06366380
126POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06144422
127* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06027405
128SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04111324
129* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02724156
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02319698
131* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01899844
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01573616
133* SOX2_16153702_ChIP-ChIP_HESCs_Human1.00495970
134YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00238832
135KAP1_27257070_Chip-Seq_ESCs_Mouse0.99950964
136FUS_26573619_Chip-Seq_HEK293_Human0.99531600
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99411035
138EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98923452
139* NANOG_16153702_ChIP-ChIP_HESCs_Human0.96765411
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96629221
141* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95649410
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95592110
143EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94847219
144* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94810818
145KDM5A_27292631_Chip-Seq_BREAST_Human0.93783213
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.93306526
147CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92936654
148* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92647227
149ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90582206
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.89610332
151TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89521101
152E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88757495
153CIITA_25753668_ChIP-Seq_RAJI_Human0.88100557
154TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87152233
155TP63_19390658_ChIP-ChIP_HaCaT_Human0.87131656
156* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87111218
157NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86857929
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86439540
159TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86326103
160SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84784701
161TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84621873
162JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84412873
163TFEB_21752829_ChIP-Seq_HELA_Human0.83663141
164PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80711472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.23365428
2MP0004957_abnormal_blastocyst_morpholog3.14214466
3MP0005257_abnormal_intraocular_pressure3.07507860
4MP0008438_abnormal_cutaneous_collagen3.01957037
5MP0002653_abnormal_ependyma_morphology2.98545619
6MP0003111_abnormal_nucleus_morphology2.95079372
7MP0010094_abnormal_chromosome_stability2.93984499
8MP0010352_gastrointestinal_tract_polyps2.66522157
9MP0004133_heterotaxia2.64923481
10MP0003890_abnormal_embryonic-extraembry2.59096465
11MP0005408_hypopigmentation2.55707533
12MP0003693_abnormal_embryo_hatching2.53640974
13MP0003283_abnormal_digestive_organ2.52135405
14MP0004272_abnormal_basement_membrane2.42545831
15MP0003077_abnormal_cell_cycle2.41926890
16MP0008057_abnormal_DNA_replication2.38696490
17MP0003123_paternal_imprinting2.37909779
18MP0010368_abnormal_lymphatic_system2.37017038
19MP0001730_embryonic_growth_arrest2.28170458
20MP0003119_abnormal_digestive_system2.27109116
21MP0003941_abnormal_skin_development2.22917981
22MP0005076_abnormal_cell_differentiation2.15896450
23MP0002084_abnormal_developmental_patter2.06089243
24MP0004858_abnormal_nervous_system2.05660309
25MP0000372_irregular_coat_pigmentation2.02799080
26MP0000350_abnormal_cell_proliferation2.01690977
27MP0000537_abnormal_urethra_morphology1.98588426
28MP0002938_white_spotting1.97213361
29MP0002085_abnormal_embryonic_tissue1.95743088
30MP0008877_abnormal_DNA_methylation1.94869666
31MP0010234_abnormal_vibrissa_follicle1.92263151
32MP0010030_abnormal_orbit_morphology1.91356345
33MP0001849_ear_inflammation1.85402448
34MP0010307_abnormal_tumor_latency1.85208516
35MP0005380_embryogenesis_phenotype1.82222047
36MP0001672_abnormal_embryogenesis/_devel1.82222047
37MP0004197_abnormal_fetal_growth/weight/1.80135294
38MP0008932_abnormal_embryonic_tissue1.77768827
39MP0008058_abnormal_DNA_repair1.75574752
40MP0001697_abnormal_embryo_size1.74309737
41MP0008007_abnormal_cellular_replicative1.72436671
42MP0001299_abnormal_eye_distance/1.70292222
43MP0000015_abnormal_ear_pigmentation1.64874756
44MP0003786_premature_aging1.64419195
45MP0006054_spinal_hemorrhage1.63261845
46MP0002086_abnormal_extraembryonic_tissu1.62986718
47MP0003950_abnormal_plasma_membrane1.61095886
48MP0008995_early_reproductive_senescence1.60890956
49MP0003121_genomic_imprinting1.59992280
50MP0003984_embryonic_growth_retardation1.59255646
51MP0001293_anophthalmia1.56713539
52MP0003705_abnormal_hypodermis_morpholog1.56483062
53MP0002088_abnormal_embryonic_growth/wei1.55945541
54MP0005623_abnormal_meninges_morphology1.46089354
55MP0000569_abnormal_digit_pigmentation1.45642849
56MP0000534_abnormal_ureter_morphology1.43789639
57* MP0002080_prenatal_lethality1.43053257
58MP0005174_abnormal_tail_pigmentation1.42523670
59MP0005197_abnormal_uvea_morphology1.41906115
60MP0002877_abnormal_melanocyte_morpholog1.40264706
61* MP0002233_abnormal_nose_morphology1.39918494
62MP0004782_abnormal_surfactant_physiolog1.38474050
63MP0003385_abnormal_body_wall1.38042849
64MP0005409_darkened_coat_color1.35895452
65MP0004233_abnormal_muscle_weight1.34696354
66MP0000516_abnormal_urinary_system1.33542566
67MP0005367_renal/urinary_system_phenotyp1.33542566
68MP0003115_abnormal_respiratory_system1.29194531
69MP0003566_abnormal_cell_adhesion1.28045023
70MP0003861_abnormal_nervous_system1.25560146
71MP0002095_abnormal_skin_pigmentation1.24827373
72MP0003787_abnormal_imprinting1.23953004
73MP0008789_abnormal_olfactory_epithelium1.22344052
74MP0002090_abnormal_vision1.20627006
75MP0001324_abnormal_eye_pigmentation1.19722087
76MP0002697_abnormal_eye_size1.16877027
77MP0009278_abnormal_bone_marrow1.12520280
78MP0000371_diluted_coat_color1.11508606
79MP0003937_abnormal_limbs/digits/tail_de1.10195490
80MP0009053_abnormal_anal_canal1.09945566
81MP0004859_abnormal_synaptic_plasticity1.09057817
82MP0002111_abnormal_tail_morphology1.08329045
83MP0009384_cardiac_valve_regurgitation1.08175160
84MP0003942_abnormal_urinary_system1.07921117
85MP0002249_abnormal_larynx_morphology1.05611995
86MP0003868_abnormal_feces_composition1.05121434
87MP0000778_abnormal_nervous_system1.04871753
88MP0000432_abnormal_head_morphology1.04582117
89MP0000428_abnormal_craniofacial_morphol1.04421239
90MP0001286_abnormal_eye_development1.01273742
91MP0002177_abnormal_outer_ear0.99729739
92MP0003136_yellow_coat_color0.99433247
93MP0009780_abnormal_chondrocyte_physiolo0.98597408
94MP0003880_abnormal_central_pattern0.98395710
95MP0002736_abnormal_nociception_after0.98391897
96MP0003567_abnormal_fetal_cardiomyocyte0.96813276
97MP0009697_abnormal_copulation0.96718550
98MP0004270_analgesia0.92716184
99MP0002075_abnormal_coat/hair_pigmentati0.92661365
100MP0005248_abnormal_Harderian_gland0.92659734
101MP0000647_abnormal_sebaceous_gland0.90576098
102MP0003634_abnormal_glial_cell0.90292437
103MP0002925_abnormal_cardiovascular_devel0.89730866
104MP0009703_decreased_birth_body0.89420811
105MP0003806_abnormal_nucleotide_metabolis0.88885205
106MP0003935_abnormal_craniofacial_develop0.87372558
107MP0001177_atelectasis0.86211855
108MP0003755_abnormal_palate_morphology0.85986319
109MP0009250_abnormal_appendicular_skeleto0.85922512
110MP0003122_maternal_imprinting0.85785425
111MP0000920_abnormal_myelination0.84707561
112MP0005508_abnormal_skeleton_morphology0.84062506
113MP0002896_abnormal_bone_mineralization0.83654868
114MP0004264_abnormal_extraembryonic_tissu0.83201396
115MP0000313_abnormal_cell_death0.82711888
116MP0005391_vision/eye_phenotype0.82369540
117MP0001958_emphysema0.81928474
118* MP0001145_abnormal_male_reproductive0.81346997
119MP0001879_abnormal_lymphatic_vessel0.80831034
120MP0001186_pigmentation_phenotype0.77591065
121MP0002152_abnormal_brain_morphology0.77206008
122MP0000579_abnormal_nail_morphology0.76635276
123* MP0002210_abnormal_sex_determination0.76214792
124MP0003091_abnormal_cell_migration0.75360505
125MP0005193_abnormal_anterior_eye0.74939718
126MP0002282_abnormal_trachea_morphology0.74602408
127MP0001915_intracranial_hemorrhage0.74318060
128MP0000733_abnormal_muscle_development0.74235977
129MP0000566_synostosis0.73173811
130MP0002116_abnormal_craniofacial_bone0.73130348
131MP0002751_abnormal_autonomic_nervous0.72517022
132MP0009672_abnormal_birth_weight0.72495873
133MP0003632_abnormal_nervous_system0.72089550
134MP0003718_maternal_effect0.71966035
135MP0002081_perinatal_lethality0.71400264
136MP0002092_abnormal_eye_morphology0.71389354
137MP0000762_abnormal_tongue_morphology0.70202920
138MP0004885_abnormal_endolymph0.70064174
139MP0001175_abnormal_lung_morphology0.69681986
140MP0001485_abnormal_pinna_reflex0.67119810
141MP0006292_abnormal_olfactory_placode0.66488419
142MP0003936_abnormal_reproductive_system0.66442881
143MP0002114_abnormal_axial_skeleton0.64850489
144MP0000049_abnormal_middle_ear0.64785085
145MP0005394_taste/olfaction_phenotype0.63446078
146MP0005499_abnormal_olfactory_system0.63446078
147MP0005621_abnormal_cell_physiology0.60620911
148MP0008770_decreased_survivor_rate0.60376479
149MP0002127_abnormal_cardiovascular_syste0.60174831

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.95935152
2Abnormality of the labia minora (HP:0012880)4.38652172
3Abnormality of the astrocytes (HP:0100707)4.07622432
4Astrocytoma (HP:0009592)4.07622432
5Glioma (HP:0009733)3.33645285
6Medulloblastoma (HP:0002885)3.32229994
7Premature rupture of membranes (HP:0001788)3.18987670
8Neoplasm of the oral cavity (HP:0100649)3.18077835
9Esophageal atresia (HP:0002032)3.11063050
10Agnosia (HP:0010524)3.03591812
11Colon cancer (HP:0003003)3.01918236
12Supernumerary spleens (HP:0009799)2.99092235
13Selective tooth agenesis (HP:0001592)2.99003750
14White forelock (HP:0002211)2.95665899
15Rib fusion (HP:0000902)2.90986689
16Abnormality of the lower motor neuron (HP:0002366)2.78777119
17Microglossia (HP:0000171)2.72642162
18Absent radius (HP:0003974)2.72617809
19Arterial tortuosity (HP:0005116)2.71177019
20Patchy hypopigmentation of hair (HP:0011365)2.70938235
21Biliary tract neoplasm (HP:0100574)2.69338612
22Shawl scrotum (HP:0000049)2.68186936
23Aplasia involving forearm bones (HP:0009822)2.65649928
24Absent forearm bone (HP:0003953)2.65649928
25Rhabdomyosarcoma (HP:0002859)2.65308101
26Cortical dysplasia (HP:0002539)2.60668192
27Hypopigmentation of the fundus (HP:0007894)2.58120433
28Aplasia/hypoplasia of the humerus (HP:0006507)2.54385406
29Short humerus (HP:0005792)2.52094018
30Vascular tortuosity (HP:0004948)2.50531742
31Gastrointestinal carcinoma (HP:0002672)2.49467025
32Malignant gastrointestinal tract tumors (HP:0006749)2.49467025
33Abnormality of the salivary glands (HP:0010286)2.47630928
34Neoplasm of striated muscle (HP:0009728)2.45771324
35Missing ribs (HP:0000921)2.44512501
36Rectovaginal fistula (HP:0000143)2.39363407
37Rectal fistula (HP:0100590)2.39363407
38Gastrointestinal atresia (HP:0002589)2.39317795
39Protrusio acetabuli (HP:0003179)2.38256133
40Abnormal lung lobation (HP:0002101)2.35192626
41Urethral obstruction (HP:0000796)2.29371613
42Hypoplasia of the fovea (HP:0007750)2.28678438
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.28678438
44Birth length less than 3rd percentile (HP:0003561)2.20387359
45Abnormality of abdominal situs (HP:0011620)2.19159306
46Abdominal situs inversus (HP:0003363)2.19159306
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.18654134
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18628248
49Interstitial pulmonary disease (HP:0006530)2.18552533
50Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.17482442
51Skull defect (HP:0001362)2.16053349
52Intestinal fistula (HP:0100819)2.14770469
53Breast hypoplasia (HP:0003187)2.14562947
54Soft skin (HP:0000977)2.10337157
55Patellar aplasia (HP:0006443)2.09459013
56Stenosis of the external auditory canal (HP:0000402)2.08220460
57Neonatal short-limb short stature (HP:0008921)2.08125497
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.07669661
59Absent epiphyses (HP:0010577)2.07669661
60Degeneration of anterior horn cells (HP:0002398)2.06993108
61Abnormality of the anterior horn cell (HP:0006802)2.06993108
62Blue irides (HP:0000635)2.06484790
63Anophthalmia (HP:0000528)2.06285849
64Abnormality of dentin (HP:0010299)2.05626320
65Small epiphyses (HP:0010585)2.03984006
66Heterochromia iridis (HP:0001100)2.03754839
67Pseudobulbar signs (HP:0002200)2.02658206
68Hand muscle atrophy (HP:0009130)2.01001206
69Spinal muscular atrophy (HP:0007269)2.00914035
70Abnormal auditory evoked potentials (HP:0006958)1.99984867
71Increased nuchal translucency (HP:0010880)1.98728773
72Upper limb muscle weakness (HP:0003484)1.98519804
73Breast aplasia (HP:0100783)1.98051610
74Deviation of the thumb (HP:0009603)1.97483131
75Impulsivity (HP:0100710)1.95497383
76Fused cervical vertebrae (HP:0002949)1.95025196
77Vaginal fistula (HP:0004320)1.94653331
78Broad thumb (HP:0011304)1.94317066
79Abnormal number of incisors (HP:0011064)1.92189589
80Uterine neoplasm (HP:0010784)1.89799768
81Supernumerary bones of the axial skeleton (HP:0009144)1.89638794
82Aplasia/Hypoplasia of the patella (HP:0006498)1.89268634
83Intestinal polyp (HP:0005266)1.88423802
84Hemivertebrae (HP:0002937)1.88293883
85Annular pancreas (HP:0001734)1.88162455
86Supernumerary ribs (HP:0005815)1.88108641
87Vertebral fusion (HP:0002948)1.88093174
88Ocular albinism (HP:0001107)1.87980677
89Vertebral hypoplasia (HP:0008417)1.87253872
90Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87253872
91Proximal placement of thumb (HP:0009623)1.86782545
92Intestinal polyposis (HP:0200008)1.85435115
93Angiofibromas (HP:0010615)1.85042452
94Adenoma sebaceum (HP:0009720)1.85042452
95Bifid tongue (HP:0010297)1.84448364
96Ankle contracture (HP:0006466)1.83989118
97Carpal bone hypoplasia (HP:0001498)1.83058682
98Hypoplastic pelvis (HP:0008839)1.82770880
99Volvulus (HP:0002580)1.80529363
100Abnormality of the fovea (HP:0000493)1.80195726
101Freckling (HP:0001480)1.79895244
102Malignant neoplasm of the central nervous system (HP:0100836)1.79712811
103Ovarian neoplasm (HP:0100615)1.79710802
104High anterior hairline (HP:0009890)1.79619617
105Short 1st metacarpal (HP:0010034)1.79609449
106Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79609449
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79556525
108Basal cell carcinoma (HP:0002671)1.78486012
109Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78287551
110Aplasia/Hypoplasia of the breasts (HP:0010311)1.77645355
111Resting tremor (HP:0002322)1.77465745
112Papillary thyroid carcinoma (HP:0002895)1.76862908
113Insomnia (HP:0100785)1.76512855
114Bilateral microphthalmos (HP:0007633)1.75375370
115Atresia of the external auditory canal (HP:0000413)1.73665492
116Distal upper limb amyotrophy (HP:0007149)1.73334886
117Upper limb amyotrophy (HP:0009129)1.73334886
118Shallow orbits (HP:0000586)1.73226443
119Facial hemangioma (HP:0000329)1.72720096
120Renal duplication (HP:0000075)1.72686501
121Aplasia/Hypoplasia of the macula (HP:0008059)1.72017201
122Adactyly (HP:0009776)1.71442892
123Vertebral compression fractures (HP:0002953)1.70244216
124Bladder diverticulum (HP:0000015)1.69877826
125Alacrima (HP:0000522)1.69413502
126Intestinal atresia (HP:0011100)1.69051422
127Meckel diverticulum (HP:0002245)1.68902669
128Tracheoesophageal fistula (HP:0002575)1.67847501
129Abnormality of the diencephalon (HP:0010662)1.67679835
130Preauricular skin tag (HP:0000384)1.66579668
131Neuroblastoma (HP:0003006)1.65230190
132Primitive neuroectodermal tumor (HP:0030065)1.65230190
133Neuroblastic tumors (HP:0004376)1.65230190
134Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.65230190
135Short phalanx of the thumb (HP:0009660)1.65203211
136Skin tags (HP:0010609)1.64586760
137Midline defect of the nose (HP:0004122)1.64543022
138Cerebral aneurysm (HP:0004944)1.64303702
139Chromsome breakage (HP:0040012)1.63310043
140Large earlobe (HP:0009748)1.63095729
141Nervous tissue neoplasm (HP:0030060)1.62963346
142Neuroectodermal neoplasm (HP:0030061)1.62963346
143Neuroepithelial neoplasm (HP:0030063)1.62963346
144Nuclear cataract (HP:0100018)1.62733557
145Abnormality of the ileum (HP:0001549)1.62347668
146Ectopic kidney (HP:0000086)1.61927257
147Adrenal hypoplasia (HP:0000835)1.61324032
148Vertebral arch anomaly (HP:0008438)1.60378372
149Iris hypopigmentation (HP:0007730)1.60169103
150Coronal craniosynostosis (HP:0004440)1.56608311
151Aplasia/Hypoplasia affecting the retina (HP:0008061)1.56167853
152Megalencephaly (HP:0001355)1.56049962
153Renal hypoplasia (HP:0000089)1.54457352
154Protruding ear (HP:0000411)1.53395007
155Natal tooth (HP:0000695)1.51579968
156Decreased lacrimation (HP:0000633)1.49971369
157Arnold-Chiari malformation (HP:0002308)1.49336447
158Follicular hyperkeratosis (HP:0007502)1.49122169
159Aortic dissection (HP:0002647)1.47548452
160Spinal rigidity (HP:0003306)1.47332251
161Cutaneous finger syndactyly (HP:0010554)1.46348863
162Neoplasm of the peripheral nervous system (HP:0100007)1.46089790
163Overlapping toe (HP:0001845)1.45304146
164Leiomyosarcoma (HP:0100243)1.45298338
165Uterine leiomyosarcoma (HP:0002891)1.45298338
166Elfin facies (HP:0004428)1.44877761
167Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.43976378
168Nephroblastoma (Wilms tumor) (HP:0002667)1.43677724
169Hypoplasia of the iris (HP:0007676)1.42989043
170Spastic diplegia (HP:0001264)1.42802359
171Preaxial foot polydactyly (HP:0001841)1.42594504
172Aplasia involving bones of the upper limbs (HP:0009823)1.42577946
173Aplasia of the phalanges of the hand (HP:0009802)1.42577946
174Aplasia involving bones of the extremities (HP:0009825)1.42577946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.21751615
2CDK123.93665905
3NEK13.61348319
4CDC73.27287765
5WEE12.71643003
6BUB12.48045408
7TTK2.40878547
8TSSK62.33084373
9MAP3K92.17197857
10PAK42.07564706
11LATS21.98945987
12PBK1.82557249
13PNCK1.81870766
14TNIK1.80439117
15CASK1.79377123
16MST1R1.72551003
17NEK21.71712730
18SCYL21.68347913
19EIF2AK31.61756486
20PLK11.60250195
21PLK31.59172749
22RPS6KB21.57335840
23EPHB21.54325059
24ALK1.53067183
25CDK71.46547712
26AKT31.45355604
27STK38L1.41976089
28CHEK21.35791326
29CCNB11.34493541
30TYRO31.34079835
31EEF2K1.34069596
32MKNK21.33597510
33DAPK11.30969465
34ICK1.30615551
35BRD41.28863843
36PASK1.28355726
37CSNK1G11.25114741
38KSR21.22258111
39TRIM281.21797443
40MKNK11.19054722
41STK31.18259116
42LATS11.17872364
43LIMK11.12986237
44RIPK11.12983777
45PLK41.11106603
46AURKA1.10893730
47PRKD31.10411367
48CSNK1A1L1.09972166
49PKN21.09847743
50CDK61.08826136
51ATR1.08318330
52CHEK11.06232246
53MARK11.05393324
54CSNK1G21.03983923
55WNK31.03380165
56CSNK1G31.02540430
57MAP3K81.00799243
58BMX0.94364189
59TGFBR20.92498882
60BCR0.92395889
61PDGFRA0.92387393
62MTOR0.91525595
63CDK20.90925164
64FGFR10.90916544
65AURKB0.90417575
66ERBB30.89951663
67NEK90.88543025
68MET0.88220895
69BMPR1B0.86448334
70SRPK10.86349448
71KSR10.86275228
72VRK20.85436919
73DMPK0.84545479
74PAK60.84502931
75EPHA40.84036912
76FER0.82987784
77ERBB40.82315762
78STK380.81499780
79MOS0.79899649
80ROCK20.79515783
81ATM0.79193153
82CDK40.78741033
83MAP3K100.78436965
84NTRK10.77327412
85STK100.76371625
86PDK30.74794124
87PDK40.74794124
88TAF10.73310985
89TESK20.73214251
90MATK0.73181261
91NUAK10.73079148
92DAPK20.72743262
93DDR20.71755347
94EIF2AK20.69313892
95NTRK30.68162828
96PRKCI0.67745253
97CSNK1E0.67295815
98PLK20.66644830
99BRSK20.64098864
100CDK10.63599950
101LMTK20.63579502
102PAK20.63183300
103STK390.63018403
104STK240.61422917
105CSNK1D0.60837896
106CDK140.60815905
107ROCK10.60737416
108AKT20.60626155
109MAP3K40.60450280
110NTRK20.59456430
111CDK150.59356842
112BRAF0.58790772
113TGFBR10.58769915
114CDK180.58162783
115TESK10.57149011
116RAF10.57086855
117BRSK10.56167611
118PDGFRB0.55967102
119CDK11A0.53475676
120FGFR20.53175129
121PTK20.51930901
122FLT30.49931290
123GSK3A0.49424512
124CAMK1D0.48233731
125EIF2AK10.47477850
126MINK10.47385025
127MAPK100.45886972
128GSK3B0.45598375
129NME20.45421379
130PRKDC0.45382245
131CSNK2A20.44072482
132PAK10.43965481
133MELK0.43904165
134CDK80.43527096
135YES10.43441111
136MAPKAPK30.42832542
137ZAK0.42778650
138VRK10.42399500
139PRKCG0.42189754
140PDK20.39984727
141STK40.37871739
142ABL20.37377414
143MAPK140.37190037
144FGR0.36889893

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.47323765
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36084253
3DNA replication_Homo sapiens_hsa030303.16671013
4RNA transport_Homo sapiens_hsa030132.98199030
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63990009
6Spliceosome_Homo sapiens_hsa030402.56790040
7Vitamin B6 metabolism_Homo sapiens_hsa007502.45129846
8One carbon pool by folate_Homo sapiens_hsa006702.37687174
9Cell cycle_Homo sapiens_hsa041102.30379405
10mRNA surveillance pathway_Homo sapiens_hsa030152.04899718
11Steroid biosynthesis_Homo sapiens_hsa001002.02961969
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97904159
13Hippo signaling pathway_Homo sapiens_hsa043901.89726484
14Base excision repair_Homo sapiens_hsa034101.84494972
15ECM-receptor interaction_Homo sapiens_hsa045121.84138065
16Oocyte meiosis_Homo sapiens_hsa041141.70860915
17Nucleotide excision repair_Homo sapiens_hsa034201.68991124
18RNA polymerase_Homo sapiens_hsa030201.68350073
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63248875
20Basal cell carcinoma_Homo sapiens_hsa052171.62061666
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56462830
22Homologous recombination_Homo sapiens_hsa034401.52960918
23Thyroid cancer_Homo sapiens_hsa052161.52814034
24Adherens junction_Homo sapiens_hsa045201.52602158
25Fanconi anemia pathway_Homo sapiens_hsa034601.45467536
26Hedgehog signaling pathway_Homo sapiens_hsa043401.40130007
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37371187
28Bladder cancer_Homo sapiens_hsa052191.37191359
29Non-homologous end-joining_Homo sapiens_hsa034501.33826067
30MicroRNAs in cancer_Homo sapiens_hsa052061.32719231
31p53 signaling pathway_Homo sapiens_hsa041151.32371279
32Protein export_Homo sapiens_hsa030601.32069533
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30221168
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.30206742
35Colorectal cancer_Homo sapiens_hsa052101.27483354
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25526871
37mTOR signaling pathway_Homo sapiens_hsa041501.23832978
38Tight junction_Homo sapiens_hsa045301.23575167
39Fatty acid elongation_Homo sapiens_hsa000621.21886526
40RNA degradation_Homo sapiens_hsa030181.21200337
41TGF-beta signaling pathway_Homo sapiens_hsa043501.15227587
42Endometrial cancer_Homo sapiens_hsa052131.10768176
43Biosynthesis of amino acids_Homo sapiens_hsa012301.09201917
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07076667
45Synaptic vesicle cycle_Homo sapiens_hsa047211.06124053
46Axon guidance_Homo sapiens_hsa043601.04595712
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04573152
48Propanoate metabolism_Homo sapiens_hsa006401.04019765
49Lysine degradation_Homo sapiens_hsa003101.03844593
50Wnt signaling pathway_Homo sapiens_hsa043101.03083214
51Notch signaling pathway_Homo sapiens_hsa043300.98720971
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98499710
53Basal transcription factors_Homo sapiens_hsa030220.96589761
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.95853151
55N-Glycan biosynthesis_Homo sapiens_hsa005100.95603933
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95567019
57Melanoma_Homo sapiens_hsa052180.95319575
58Long-term potentiation_Homo sapiens_hsa047200.94357193
59Glioma_Homo sapiens_hsa052140.92186265
60Thyroid hormone synthesis_Homo sapiens_hsa049180.89506951
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84974347
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83662043
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81884616
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81753764
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81259997
66Viral carcinogenesis_Homo sapiens_hsa052030.80216394
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80076244
68Circadian rhythm_Homo sapiens_hsa047100.79661912
69Pyrimidine metabolism_Homo sapiens_hsa002400.79198201
70Fructose and mannose metabolism_Homo sapiens_hsa000510.76048593
71Melanogenesis_Homo sapiens_hsa049160.75459522
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75243541
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75178796
74Alcoholism_Homo sapiens_hsa050340.74607878
75Fatty acid metabolism_Homo sapiens_hsa012120.73564067
76Gap junction_Homo sapiens_hsa045400.73528940
77Proteoglycans in cancer_Homo sapiens_hsa052050.73014436
78ErbB signaling pathway_Homo sapiens_hsa040120.72685411
79Fatty acid biosynthesis_Homo sapiens_hsa000610.72007381
80Estrogen signaling pathway_Homo sapiens_hsa049150.71363855
81Pathways in cancer_Homo sapiens_hsa052000.71078954
82Sphingolipid metabolism_Homo sapiens_hsa006000.70918754
83HTLV-I infection_Homo sapiens_hsa051660.70019072
84Carbon metabolism_Homo sapiens_hsa012000.69577551
85Epstein-Barr virus infection_Homo sapiens_hsa051690.68387196
86HIF-1 signaling pathway_Homo sapiens_hsa040660.66768469
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65916245
88Non-small cell lung cancer_Homo sapiens_hsa052230.65887405
89Folate biosynthesis_Homo sapiens_hsa007900.65753193
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65144301
91Protein digestion and absorption_Homo sapiens_hsa049740.64255934
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64216790
93Rap1 signaling pathway_Homo sapiens_hsa040150.63834174
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63514546
95Small cell lung cancer_Homo sapiens_hsa052220.63417000
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61980772
97Amphetamine addiction_Homo sapiens_hsa050310.61657394
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61218817
99Proteasome_Homo sapiens_hsa030500.60886182
100Glutathione metabolism_Homo sapiens_hsa004800.59958519
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59273137
102Pyruvate metabolism_Homo sapiens_hsa006200.59085488
103Chronic myeloid leukemia_Homo sapiens_hsa052200.57945832
104Dorso-ventral axis formation_Homo sapiens_hsa043200.57772886
105Dilated cardiomyopathy_Homo sapiens_hsa054140.57636884
106Glutamatergic synapse_Homo sapiens_hsa047240.57410546
107Ribosome_Homo sapiens_hsa030100.55993166
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.55405988
109Prostate cancer_Homo sapiens_hsa052150.54723896
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51458309
111Prion diseases_Homo sapiens_hsa050200.51341292
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.51257258
113Olfactory transduction_Homo sapiens_hsa047400.50669587
114Systemic lupus erythematosus_Homo sapiens_hsa053220.50508078
115Focal adhesion_Homo sapiens_hsa045100.50295386
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50106517
117Complement and coagulation cascades_Homo sapiens_hsa046100.49136279
118Selenocompound metabolism_Homo sapiens_hsa004500.48387841
119Renal cell carcinoma_Homo sapiens_hsa052110.47374083
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46701608
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.46353669
122Dopaminergic synapse_Homo sapiens_hsa047280.45773344
123Lysosome_Homo sapiens_hsa041420.45651527
124GnRH signaling pathway_Homo sapiens_hsa049120.44764740
125Purine metabolism_Homo sapiens_hsa002300.43162694
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42841304
127Glucagon signaling pathway_Homo sapiens_hsa049220.42550597
128Vibrio cholerae infection_Homo sapiens_hsa051100.41810902
129Long-term depression_Homo sapiens_hsa047300.40629658
130Nicotine addiction_Homo sapiens_hsa050330.40242915
131VEGF signaling pathway_Homo sapiens_hsa043700.39666514
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39349604
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38284252
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37585614
135Nitrogen metabolism_Homo sapiens_hsa009100.37383565
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37208604
137Insulin signaling pathway_Homo sapiens_hsa049100.36819675

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