ETV6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.92663781
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92663781
3antigen processing and presentation of endogenous antigen (GO:0019883)4.74257925
4definitive hemopoiesis (GO:0060216)3.99701252
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93649341
6positive regulation of gamma-delta T cell activation (GO:0046645)3.88507841
7positive regulation of B cell differentiation (GO:0045579)3.59057714
8positive regulation of natural killer cell differentiation (GO:0032825)3.58826286
9cellular extravasation (GO:0045123)3.50882044
10positive regulation of granulocyte differentiation (GO:0030854)3.48299911
11ribosomal small subunit assembly (GO:0000028)3.46360252
12NIK/NF-kappaB signaling (GO:0038061)3.44775281
13macrophage activation involved in immune response (GO:0002281)3.43230824
14B cell receptor signaling pathway (GO:0050853)3.42711280
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39792916
16negative regulation of cell killing (GO:0031342)3.39792916
17embryonic process involved in female pregnancy (GO:0060136)3.38552566
18regulation of integrin activation (GO:0033623)3.38132414
19detection of other organism (GO:0098543)3.37286734
20germinal center formation (GO:0002467)3.34770741
21regulation of mast cell degranulation (GO:0043304)3.34395328
22detection of bacterium (GO:0016045)3.30011817
23antigen processing and presentation via MHC class Ib (GO:0002475)3.28387824
24negative regulation of T-helper cell differentiation (GO:0045623)3.25261983
25negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25261983
26cellular response to zinc ion (GO:0071294)3.24497593
27regulation of mast cell activation (GO:0033003)3.18403147
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18324233
29response to host immune response (GO:0052572)3.18112884
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18112884
31negative regulation of erythrocyte differentiation (GO:0045647)3.15954613
32immunoglobulin mediated immune response (GO:0016064)3.14599727
33regulation of B cell apoptotic process (GO:0002902)3.13214692
34regulation of mast cell activation involved in immune response (GO:0033006)3.12397638
35response to muramyl dipeptide (GO:0032495)3.11914477
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10413884
37positive regulation of mast cell activation (GO:0033005)3.09614274
38T-helper 1 type immune response (GO:0042088)3.08283756
39response to interferon-beta (GO:0035456)3.07162213
40mature B cell differentiation involved in immune response (GO:0002313)3.05165633
41regulation of gamma-delta T cell differentiation (GO:0045586)3.00472139
42negative thymic T cell selection (GO:0045060)2.99267460
43positive regulation of mast cell activation involved in immune response (GO:0033008)2.97962190
44positive regulation of mast cell degranulation (GO:0043306)2.97962190
45myeloid cell activation involved in immune response (GO:0002275)2.97579740
46Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96720725
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96674249
48response to host (GO:0075136)2.96674249
49response to host defenses (GO:0052200)2.96674249
50myeloid dendritic cell activation (GO:0001773)2.95932859
51regulation of B cell differentiation (GO:0045577)2.94792943
52regulation of gamma-delta T cell activation (GO:0046643)2.91988153
53microglial cell activation (GO:0001774)2.91839823
54regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88465937
55regulation of leukocyte degranulation (GO:0043300)2.87350514
56cellular response to exogenous dsRNA (GO:0071360)2.87199388
57negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.86617949
58response to peptidoglycan (GO:0032494)2.85012345
59regulation of germinal center formation (GO:0002634)2.84782533
60positive thymic T cell selection (GO:0045059)2.84309050
61regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.84116596
62negative regulation of T cell mediated immunity (GO:0002710)2.83524376
63negative regulation of interleukin-12 production (GO:0032695)2.83233604
64B cell mediated immunity (GO:0019724)2.82791562
65regulation of alpha-beta T cell proliferation (GO:0046640)2.82381480
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82255957
67regulation of interferon-beta biosynthetic process (GO:0045357)2.82055592
68detection of external biotic stimulus (GO:0098581)2.81613610
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81067029
70negative T cell selection (GO:0043383)2.80773388
71telomere maintenance via semi-conservative replication (GO:0032201)2.80206778
72negative regulation of cytokine production involved in immune response (GO:0002719)2.80024128
73response to interferon-alpha (GO:0035455)2.79329173
74histamine secretion (GO:0001821)2.77488662
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76997056
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.75989699
77megakaryocyte development (GO:0035855)2.75761005
78regulation of natural killer cell differentiation (GO:0032823)2.75467560
79thrombin receptor signaling pathway (GO:0070493)2.75166111
80T cell migration (GO:0072678)2.74538476
81response to type I interferon (GO:0034340)2.74347271
82replication fork processing (GO:0031297)2.73888888
83regulation of T-helper 1 cell differentiation (GO:0045625)2.72641898
84regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.72500070
85regulation of T-helper cell differentiation (GO:0045622)2.70768812
86cellular response to type I interferon (GO:0071357)2.70686526
87type I interferon signaling pathway (GO:0060337)2.70686526
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68731779
89tolerance induction (GO:0002507)2.68604264
90positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.68283847
91mature B cell differentiation (GO:0002335)2.68205115
92regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.67492672
93dosage compensation (GO:0007549)2.66695653
94positive regulation of antigen processing and presentation (GO:0002579)2.66629864
95macrophage activation (GO:0042116)2.66622187
96myeloid dendritic cell differentiation (GO:0043011)2.66524804
97cellular response to interferon-gamma (GO:0071346)2.66469080
98hepatocyte apoptotic process (GO:0097284)2.66398252
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66048950
100negative regulation of phagocytosis (GO:0050765)2.65838802
101JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65562549
102response to protozoan (GO:0001562)2.65402996
103DNA deamination (GO:0045006)2.61519946
104DNA strand elongation involved in DNA replication (GO:0006271)2.61025397
105viral transcription (GO:0019083)2.59031213
106regulation of erythrocyte differentiation (GO:0045646)2.56570585
107positive regulation of interferon-alpha production (GO:0032727)2.56101038
108DNA topological change (GO:0006265)2.54857903
109telomere maintenance via recombination (GO:0000722)2.54495721
110execution phase of apoptosis (GO:0097194)2.54089831
111neutrophil activation involved in immune response (GO:0002283)2.53618248
112negative regulation of granulocyte differentiation (GO:0030853)2.53554327
113DNA strand elongation (GO:0022616)2.51301013
114positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49323900
115DNA unwinding involved in DNA replication (GO:0006268)2.48991961
116cellular response to interferon-beta (GO:0035458)2.48749636
117defense response to protozoan (GO:0042832)2.48301579
1183-UTR-mediated mRNA stabilization (GO:0070935)2.46078212
119production of molecular mediator involved in inflammatory response (GO:0002532)2.45902942
120translational termination (GO:0006415)2.45302921
121negative regulation of viral genome replication (GO:0045071)2.44426008
122regulation of necroptotic process (GO:0060544)2.43805666
123positive regulation of protein homooligomerization (GO:0032464)2.43322334
124T cell homeostasis (GO:0043029)2.42673713
125regulation of interferon-alpha production (GO:0032647)2.42045989
126meiotic chromosome segregation (GO:0045132)2.40598436
127dendritic cell differentiation (GO:0097028)2.39514662
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.37721718
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.37721718
130modulation by symbiont of host immune response (GO:0052553)2.37721718
131positive regulation by symbiont of host defense response (GO:0052509)2.37721718
132modulation by symbiont of host defense response (GO:0052031)2.37721718
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.37721718
134interferon-gamma-mediated signaling pathway (GO:0060333)2.32667832
135negative regulation by host of viral transcription (GO:0043922)2.32007562
136T cell apoptotic process (GO:0070231)2.31765022
137positive regulation of interferon-beta production (GO:0032728)2.31084340
138positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.31015688
139mitotic recombination (GO:0006312)2.30726561
140neutrophil activation (GO:0042119)2.30488148
141leukocyte aggregation (GO:0070486)2.28976307
142proline biosynthetic process (GO:0006561)2.27796547
143regulation of antigen processing and presentation (GO:0002577)2.27149170
144positive regulation of natural killer cell activation (GO:0032816)2.26744572
145regulation of RIG-I signaling pathway (GO:0039535)2.25944055
146negative regulation of RNA splicing (GO:0033119)2.25730410
147natural killer cell differentiation (GO:0001779)2.24804833
148leukocyte cell-cell adhesion (GO:0007159)2.23871923
149formation of translation preinitiation complex (GO:0001731)2.21634105
150negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.21391465
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.21384572
152angiogenesis involved in wound healing (GO:0060055)2.20761068
153granulocyte activation (GO:0036230)2.20299694
154cytokine secretion (GO:0050663)2.19078960
155actin nucleation (GO:0045010)2.18067576
156lymphocyte homeostasis (GO:0002260)2.17625418
157regulation of B cell receptor signaling pathway (GO:0050855)2.17469631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.49970327
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.00637154
3* IRF8_22096565_ChIP-ChIP_GC-B_Human3.76806881
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.28531607
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.00025422
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99638525
7SCL_19346495_ChIP-Seq_HPC-7_Human2.93820544
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80294123
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79196969
10VDR_21846776_ChIP-Seq_THP-1_Human2.77598202
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75035712
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62391453
13* MYC_22102868_ChIP-Seq_BL_Human2.49720725
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44296113
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.40396658
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39626901
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39000249
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35136828
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31565282
20* VDR_24787735_ChIP-Seq_THP-1_Human2.28463221
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16251997
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12477729
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09424300
24* IRF8_27001747_Chip-Seq_BMDM_Mouse2.07445653
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06288535
26SPI1_23547873_ChIP-Seq_NB4_Human2.02500523
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99392406
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98828165
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95984486
30* VDR_24763502_ChIP-Seq_THP-1_Human1.94198167
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91147649
32* MAF_26560356_Chip-Seq_TH1_Human1.90588155
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85700812
34MYB_26560356_Chip-Seq_TH2_Human1.85019065
35* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84567706
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.84359055
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83365204
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82845105
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.81558666
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80247945
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.78940416
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.74860658
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74452330
44* GATA2_21666600_ChIP-Seq_HMVEC_Human1.70912911
45* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69941750
46* MYB_26560356_Chip-Seq_TH1_Human1.69453603
47GATA3_26560356_Chip-Seq_TH2_Human1.59240291
48* UTX_26944678_Chip-Seq_JUKART_Human1.54875449
49* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51265755
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44790565
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41546611
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.41203717
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.40086575
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39892903
55* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37981656
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37163366
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35841391
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34488615
59GATA1_19941826_ChIP-Seq_K562_Human1.33804248
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.31353530
61* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31019909
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26827600
63* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26395952
64* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26148287
65PU_27001747_Chip-Seq_BMDM_Mouse1.25081819
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24442670
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24070518
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22006233
69RUNX_20019798_ChIP-Seq_JUKART_Human1.21630753
70MAF_26560356_Chip-Seq_TH2_Human1.21108858
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20541882
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20335552
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20198494
74GATA2_19941826_ChIP-Seq_K562_Human1.20071956
75SPI1_23127762_ChIP-Seq_K562_Human1.19691073
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19387320
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18013499
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16819780
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13018543
80* KDM2B_26808549_Chip-Seq_DND41_Human1.08890867
81* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08466998
82* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07215424
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06718098
84* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06172614
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02858429
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01997859
87GATA1_22025678_ChIP-Seq_K562_Human1.00184975
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98282558
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97988783
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97751469
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97732424
92* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97563231
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97406595
94NCOR1_26117541_ChIP-Seq_K562_Human0.97384214
95* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96200108
96AR_21909140_ChIP-Seq_LNCAP_Human0.96141715
97* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96022537
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.95087612
99TFEB_21752829_ChIP-Seq_HELA_Human0.94632596
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94538822
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94375380
102CIITA_25753668_ChIP-Seq_RAJI_Human0.94181105
103* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93206413
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92011202
105* SMRT_27268052_Chip-Seq_Bcells_Human0.91988886
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90832124
107XRN2_22483619_ChIP-Seq_HELA_Human0.88984521
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.87535400
109VDR_23849224_ChIP-Seq_CD4+_Human0.86694561
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86511981
111EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86369193
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84493615
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84351966
114NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84088377
115GATA3_27048872_Chip-Seq_THYMUS_Human0.82683423
116ELK1_19687146_ChIP-ChIP_HELA_Human0.79220485
117STAT1_20625510_ChIP-Seq_HELA_Human0.77199443
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76465979
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74882972
120LXR_22292898_ChIP-Seq_THP-1_Human0.74515431
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73389344
122KDM5A_27292631_Chip-Seq_BREAST_Human0.73322607
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72945781
124* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72618837
125GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71796837
126* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71497864
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70551531
128* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67093172
129* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.64494341

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.38830269
2MP0002396_abnormal_hematopoietic_system3.27558988
3MP0000685_abnormal_immune_system2.94358344
4MP0008057_abnormal_DNA_replication2.66082448
5MP0003436_decreased_susceptibility_to2.46948108
6MP0009785_altered_susceptibility_to2.39952736
7* MP0009278_abnormal_bone_marrow2.39451352
8* MP0005397_hematopoietic_system_phenotyp2.37036971
9* MP0001545_abnormal_hematopoietic_system2.37036971
10MP0010352_gastrointestinal_tract_polyps2.33349471
11MP0002166_altered_tumor_susceptibility2.23842210
12MP0002148_abnormal_hypersensitivity_rea2.21733107
13MP0005025_abnormal_response_to2.18846254
14* MP0004808_abnormal_hematopoietic_stem2.18200134
15MP0005174_abnormal_tail_pigmentation2.11495001
16MP0005671_abnormal_response_to2.10439360
17MP0001800_abnormal_humoral_immune2.08576907
18MP0005000_abnormal_immune_tolerance2.07819191
19MP0005464_abnormal_platelet_physiology2.04992824
20MP0001790_abnormal_immune_system2.04232868
21MP0005387_immune_system_phenotype2.04232868
22MP0002452_abnormal_antigen_presenting2.03218795
23MP0002419_abnormal_innate_immunity2.00070986
24MP0002006_tumorigenesis1.97265505
25* MP0002398_abnormal_bone_marrow1.90264260
26MP0002723_abnormal_immune_serum1.89652398
27MP0003300_gastrointestinal_ulcer1.87284416
28MP0001819_abnormal_immune_cell1.86672300
29MP0002420_abnormal_adaptive_immunity1.86612954
30MP0003763_abnormal_thymus_physiology1.85468562
31* MP0010155_abnormal_intestine_physiology1.84112157
32MP0002405_respiratory_system_inflammati1.83572455
33MP0001853_heart_inflammation1.81722510
34MP0003303_peritoneal_inflammation1.80918778
35MP0000490_abnormal_crypts_of1.78934179
36MP0001873_stomach_inflammation1.76429948
37MP0003724_increased_susceptibility_to1.67192607
38* MP0000716_abnormal_immune_system1.66618490
39MP0000689_abnormal_spleen_morphology1.65938781
40MP0000465_gastrointestinal_hemorrhage1.62456161
41MP0009333_abnormal_splenocyte_physiolog1.61695145
42MP0010094_abnormal_chromosome_stability1.60523833
43MP0002722_abnormal_immune_system1.59808684
44MP0002009_preneoplasia1.55900955
45MP0006082_CNS_inflammation1.52737974
46* MP0002429_abnormal_blood_cell1.49507678
47MP0002877_abnormal_melanocyte_morpholog1.48738879
48MP0004947_skin_inflammation1.43453898
49MP0001845_abnormal_inflammatory_respons1.40803209
50MP0004510_myositis1.39475544
51MP0005076_abnormal_cell_differentiation1.39308251
52MP0003693_abnormal_embryo_hatching1.38969778
53MP0010307_abnormal_tumor_latency1.36197993
54MP0000703_abnormal_thymus_morphology1.30864691
55MP0003448_altered_tumor_morphology1.30217329
56MP0003183_abnormal_peptide_metabolism1.30195167
57MP0003866_abnormal_defecation1.27861867
58MP0002254_reproductive_system_inflammat1.27071208
59MP0008004_abnormal_stomach_pH1.25713946
60MP0003077_abnormal_cell_cycle1.25137112
61MP0005310_abnormal_salivary_gland1.24849082
62MP0008007_abnormal_cellular_replicative1.23296404
63MP0003075_altered_response_to1.21273065
64MP0001851_eye_inflammation1.21153252
65MP0003453_abnormal_keratinocyte_physiol1.20796119
66MP0001348_abnormal_lacrimal_gland1.19708575
67MP0000858_altered_metastatic_potential1.17597818
68* MP0002019_abnormal_tumor_incidence1.14244568
69MP0003566_abnormal_cell_adhesion1.13061141
70MP0003828_pulmonary_edema1.11336676
71MP0001533_abnormal_skeleton_physiology1.11244149
72MP0003656_abnormal_erythrocyte_physiolo1.09384022
73MP0003943_abnormal_hepatobiliary_system1.09120620
74MP0005075_abnormal_melanosome_morpholog1.07304989
75MP0003172_abnormal_lysosome_physiology1.05931022
76MP0005166_decreased_susceptibility_to1.05356467
77MP0003806_abnormal_nucleotide_metabolis1.04576376
78MP0008469_abnormal_protein_level1.04437864
79MP0005058_abnormal_lysosome_morphology1.01168046
80MP0003111_abnormal_nucleus_morphology1.01111093
81MP0000343_altered_response_to0.99659354
82MP0000371_diluted_coat_color0.96177731
83MP0004957_abnormal_blastocyst_morpholog0.95362779
84MP0008058_abnormal_DNA_repair0.94522377
85MP0005023_abnormal_wound_healing0.91307892
86MP0003195_calcinosis0.91127233
87MP0002138_abnormal_hepatobiliary_system0.90745649
88MP0000350_abnormal_cell_proliferation0.88988091
89MP0000313_abnormal_cell_death0.87614473
90MP0009765_abnormal_xenobiotic_induced0.87433390
91MP0005164_abnormal_response_to0.83682634
92MP0000569_abnormal_digit_pigmentation0.81811027
93MP0009764_decreased_sensitivity_to0.79145762
94MP0002132_abnormal_respiratory_system0.77936972
95MP0006054_spinal_hemorrhage0.77377053
96MP0009840_abnormal_foam_cell0.77124031
97MP0002933_joint_inflammation0.76407571
98MP0002095_abnormal_skin_pigmentation0.74616754
99* MP0002086_abnormal_extraembryonic_tissu0.74518308
100MP0000249_abnormal_blood_vessel0.73857893
101MP0000015_abnormal_ear_pigmentation0.72642927
102MP0003191_abnormal_cellular_cholesterol0.72419110
103MP0003567_abnormal_fetal_cardiomyocyte0.72163694
104MP0005670_abnormal_white_adipose0.72067065
105MP0000477_abnormal_intestine_morphology0.70494707
106MP0004883_abnormal_blood_vessel0.69610683
107MP0002998_abnormal_bone_remodeling0.69428704
108MP0008260_abnormal_autophagy0.69411147
109MP0004264_abnormal_extraembryonic_tissu0.68672387
110MP0002277_abnormal_respiratory_mucosa0.67899270
111MP0005390_skeleton_phenotype0.66708068
112MP0005165_increased_susceptibility_to0.66439877
113MP0001915_intracranial_hemorrhage0.66358932
114MP0003795_abnormal_bone_structure0.65072977
115MP0005451_abnormal_body_composition0.64708743
116MP0008961_abnormal_basal_metabolism0.64215096
117MP0001663_abnormal_digestive_system0.63715418
118MP0002693_abnormal_pancreas_physiology0.63416846
119MP0000470_abnormal_stomach_morphology0.63005055
120MP0004381_abnormal_hair_follicle0.61948047
121MP0000598_abnormal_liver_morphology0.61203222
122MP0009115_abnormal_fat_cell0.60790424
123MP0009763_increased_sensitivity_to0.59379638
124MP0005535_abnormal_body_temperature0.58350961
125MP0003045_fibrosis0.56816796

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.20035685
2Eczematoid dermatitis (HP:0000976)4.14555123
3Myositis (HP:0100614)4.06931418
4Thrombocytosis (HP:0001894)4.05821495
5Recurrent abscess formation (HP:0002722)4.04253375
6Recurrent fungal infections (HP:0002841)3.92338389
7Recurrent bacterial skin infections (HP:0005406)3.78523917
8Elevated erythrocyte sedimentation rate (HP:0003565)3.67877947
9Pustule (HP:0200039)3.57941036
10Autoimmune hemolytic anemia (HP:0001890)3.56071677
11Recurrent viral infections (HP:0004429)3.45008372
12Agammaglobulinemia (HP:0004432)3.42438646
13Chronic otitis media (HP:0000389)3.39046605
14Orchitis (HP:0100796)3.35389205
15IgM deficiency (HP:0002850)3.25645878
16Prolonged bleeding time (HP:0003010)3.12215974
17Petechiae (HP:0000967)3.11322898
18Optic neuritis (HP:0100653)3.10764034
19Retrobulbar optic neuritis (HP:0100654)3.10764034
20Abnormality of T cell physiology (HP:0011840)3.09041649
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.04262525
22Cellulitis (HP:0100658)2.99797700
23Mediastinal lymphadenopathy (HP:0100721)2.98777766
24Abnormality of B cell number (HP:0010975)2.91709191
25IgA deficiency (HP:0002720)2.86009693
26Increased IgM level (HP:0003496)2.83570917
27Poikiloderma (HP:0001029)2.81331294
28Albinism (HP:0001022)2.74726221
29Recurrent skin infections (HP:0001581)2.71844524
30Arterial thrombosis (HP:0004420)2.68516866
31Recurrent cutaneous fungal infections (HP:0011370)2.65173789
32Chronic mucocutaneous candidiasis (HP:0002728)2.65173789
33Gastrointestinal inflammation (HP:0004386)2.62995667
34Inflammation of the large intestine (HP:0002037)2.62120000
35Periodontitis (HP:0000704)2.58948491
36Gingival bleeding (HP:0000225)2.57346328
37Stomach cancer (HP:0012126)2.57036889
38Meningitis (HP:0001287)2.56706554
39Autoimmune thrombocytopenia (HP:0001973)2.55133513
40Abnormality of liposaccharide metabolism (HP:0010968)2.54455110
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.54455110
42Abnormality of glycolipid metabolism (HP:0010969)2.54455110
43Spontaneous hematomas (HP:0007420)2.53043907
44Vasculitis (HP:0002633)2.52866184
45Spondylolisthesis (HP:0003302)2.52780231
46Impaired platelet aggregation (HP:0003540)2.52587586
47Abnormal platelet function (HP:0011869)2.52587586
48Recurrent gram-negative bacterial infections (HP:0005420)2.51621364
49Spinal cord lesions (HP:0100561)2.50987620
50Syringomyelia (HP:0003396)2.50987620
51Abnormality of T cells (HP:0002843)2.50639029
52Abnormality of the fingertips (HP:0001211)2.49859350
53Abnormal platelet volume (HP:0011876)2.49408931
54B lymphocytopenia (HP:0010976)2.48844301
55Interstitial pulmonary disease (HP:0006530)2.48783121
56Acute lymphatic leukemia (HP:0006721)2.45073194
57Epistaxis (HP:0000421)2.44880527
58Increased IgE level (HP:0003212)2.41616234
59Nasal polyposis (HP:0100582)2.41551230
60Obstructive lung disease (HP:0006536)2.40581495
61Chronic obstructive pulmonary disease (HP:0006510)2.40581495
62Dysostosis multiplex (HP:0000943)2.39821192
63Recurrent bronchitis (HP:0002837)2.37584830
64Alveolar cell carcinoma (HP:0006519)2.35950894
65Abnormality of T cell number (HP:0011839)2.35646852
66Hypochromic anemia (HP:0001931)2.35506439
67Neoplasm of the tracheobronchial system (HP:0100552)2.35413204
68Viral hepatitis (HP:0006562)2.35285079
69* Acute myeloid leukemia (HP:0004808)2.33956379
70Abnormality of macrophages (HP:0004311)2.33452583
71Abnormality of the nasal mucosa (HP:0000433)2.32880829
72Colitis (HP:0002583)2.32481395
73Chest pain (HP:0100749)2.31080344
74Chronic diarrhea (HP:0002028)2.27642379
75Hypergammaglobulinemia (HP:0010702)2.25044502
76Keratoconjunctivitis (HP:0001096)2.22863342
77Amaurosis fugax (HP:0100576)2.21115212
78Cheilitis (HP:0100825)2.20382990
79Myelodysplasia (HP:0002863)2.20036885
80Episodic fever (HP:0001954)2.18807325
81Abnormality of the prostate (HP:0008775)2.15935292
82Pulmonary embolism (HP:0002204)2.15692106
83Panhypogammaglobulinemia (HP:0003139)2.15163764
84Reticulocytopenia (HP:0001896)2.14362542
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.13987608
86Abnormal number of erythroid precursors (HP:0012131)2.13403291
87Keratoconjunctivitis sicca (HP:0001097)2.13094807
88Increased cerebral lipofuscin (HP:0011813)2.12825775
89Recurrent sinusitis (HP:0011108)2.11531938
90Abnormality of cells of the erythroid lineage (HP:0012130)2.10393236
91Increased mean platelet volume (HP:0011877)2.10341817
92Volvulus (HP:0002580)2.10271519
93IgG deficiency (HP:0004315)2.08928340
94T lymphocytopenia (HP:0005403)2.08664958
95Gastrointestinal stroma tumor (HP:0100723)2.08442897
96Leukocytosis (HP:0001974)2.08357166
97Pulmonary infiltrates (HP:0002113)2.07964325
98Abnormality of eosinophils (HP:0001879)2.05123724
99Gingivitis (HP:0000230)2.04000813
100Abnormality of male internal genitalia (HP:0000022)2.03412893
101Restrictive lung disease (HP:0002091)2.03085426
102Increased CSF protein (HP:0002922)2.02142096
103Hemoptysis (HP:0002105)2.01907584
104Encephalitis (HP:0002383)2.01875893
105Hematochezia (HP:0002573)2.01159296
106Gangrene (HP:0100758)2.00453500
107Granulocytopenia (HP:0001913)1.97291058
108Abnormality of the pleura (HP:0002103)1.97243523
109Skin ulcer (HP:0200042)1.96714203
110Facial diplegia (HP:0001349)1.96358739
111Osteomyelitis (HP:0002754)1.96163601
112Prostate neoplasm (HP:0100787)1.95126667
113Osteolytic defects of the hand bones (HP:0009699)1.94728529
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.94728529
115Papilloma (HP:0012740)1.94444074
116Verrucae (HP:0200043)1.94444074
117Polygenic inheritance (HP:0010982)1.94389926
118Urticaria (HP:0001025)1.93816859
119Lymphoma (HP:0002665)1.93451506
120Aplastic anemia (HP:0001915)1.93442967
121Thyroiditis (HP:0100646)1.93435365
122Mucopolysacchariduria (HP:0008155)1.92278569
123Urinary glycosaminoglycan excretion (HP:0003541)1.92278569
124Abnormality of cells of the lymphoid lineage (HP:0012140)1.91246451
125Gastrointestinal infarctions (HP:0005244)1.89837041
126Eosinophilia (HP:0001880)1.88813916
127Chromsome breakage (HP:0040012)1.88185798
128Menorrhagia (HP:0000132)1.84676949
129Lymphopenia (HP:0001888)1.81721172
130Vacuolated lymphocytes (HP:0001922)1.79973857
131Fatigue (HP:0012378)1.78855556
132Purpura (HP:0000979)1.74605868
133Recurrent lower respiratory tract infections (HP:0002783)1.70796296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K12.84010852
2EEF2K2.78392074
3JAK32.61493457
4MATK2.42857479
5KIT2.33675779
6MST42.30409991
7IRAK42.27977898
8MAP3K142.24894210
9PIM22.21100509
10FRK2.15902782
11BTK2.10186539
12TYK21.97253021
13TBK11.84249284
14IKBKB1.81781836
15SIK31.80250719
16PIM11.78609265
17EPHB11.75578961
18TNK21.74746901
19FLT31.74525447
20BMPR21.71474311
21IRAK11.65669408
22BLK1.64787619
23MAP3K31.63725788
24MAP3K61.63525881
25RPS6KB21.61052993
26TAOK31.60544494
27TXK1.50635888
28IKBKE1.50382570
29CSK1.49158978
30TEC1.48660668
31TRPM71.46056075
32CDK61.45614441
33MAP3K101.43116818
34ERN11.42293849
35NUAK11.41091495
36MAPK151.39823953
37MAP2K31.39747087
38CHUK1.37271353
39ZAP701.36989594
40CSF1R1.36401486
41PRPF4B1.32849839
42RPS6KA41.30156144
43IRAK31.27161730
44STK101.26864807
45MAP3K111.23628278
46PKN21.23385519
47TGFBR11.21985230
48CDK71.21729530
49BMX1.21399432
50ICK1.20321719
51TRIB31.19675868
52FGFR31.17863596
53NME21.12995033
54NEK21.08760192
55FGFR41.07915967
56EPHA31.06576223
57PIK3CG1.05844791
58SYK1.05578981
59YES11.04324356
60LRRK21.03623489
61CDK121.03040842
62JAK11.01936977
63TGFBR21.00072510
64STK40.99945983
65LCK0.98395951
66CDC70.97372075
67WEE10.95485645
68LYN0.94980286
69ATR0.93716316
70CDK40.92571896
71JAK20.88925340
72PAK40.87261646
73PTK60.86487056
74GRK70.85710927
75MAPKAPK30.85380550
76MAP4K20.85314997
77STK240.84503645
78MAP3K10.84487125
79ADRBK20.84013375
80HCK0.82992303
81RIPK40.82865882
82DDR20.81817205
83RPS6KA60.78716623
84PRKCQ0.78175497
85HIPK20.77631245
86STK30.76526114
87CDC42BPA0.74033216
88DYRK1B0.73440415
89BRSK20.72235232
90EIF2AK30.71780179
91DAPK10.71003875
92RPS6KL10.70785091
93RPS6KC10.70785091
94MKNK10.69738567
95MAPK110.67504173
96NLK0.67107977
97MARK30.66733135
98MAPK70.65690997
99MAPKAPK20.64741224
100TAOK10.62756894
101MAP3K80.61760650
102DYRK30.60957189
103ITK0.60022418
104ACVR1B0.60021989
105PTK2B0.59668488
106CLK10.59355204
107NEK90.55375063
108CDK90.54795142
109MAP2K60.53712080
110FGR0.53420286
111ABL10.53262555
112MAP3K130.53240769
113PDK10.53007840
114GRK60.51158178
115PRKD20.49235256
116FER0.48261076
117BRD40.47574384
118RPS6KA10.46667648
119EGFR0.45643183
120ALK0.45381330
121MAPK40.44871101
122TIE10.43458354
123RIPK10.42395723
124GSK3A0.42351339
125DAPK20.42094569
126SGK30.41449346
127IRAK20.40900298
128MAP3K20.40360580
129FES0.39161401
130MKNK20.39011149
131AURKB0.38867982
132RAF10.38705254
133MELK0.34743917
134MAP3K50.34232969
135* MAPK30.31788046
136SGK20.31428509
137IGF1R0.26923385

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.91645277
2Leishmaniasis_Homo sapiens_hsa051402.60942843
3Mismatch repair_Homo sapiens_hsa034302.38363354
4Base excision repair_Homo sapiens_hsa034102.23697891
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.15237493
6Legionellosis_Homo sapiens_hsa051342.12189414
7Measles_Homo sapiens_hsa051622.10921545
8Primary immunodeficiency_Homo sapiens_hsa053402.01564447
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.96769891
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92732489
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88428843
12Herpes simplex infection_Homo sapiens_hsa051681.83682262
13Osteoclast differentiation_Homo sapiens_hsa043801.77163233
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75966458
15Antigen processing and presentation_Homo sapiens_hsa046121.72823704
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72651350
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69780319
18B cell receptor signaling pathway_Homo sapiens_hsa046621.69448721
19Ribosome_Homo sapiens_hsa030101.57968763
20Allograft rejection_Homo sapiens_hsa053301.57204984
21Shigellosis_Homo sapiens_hsa051311.57139133
22Acute myeloid leukemia_Homo sapiens_hsa052211.57066657
23Chronic myeloid leukemia_Homo sapiens_hsa052201.54238279
24* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.51572563
25Homologous recombination_Homo sapiens_hsa034401.48103857
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.47061725
27Toxoplasmosis_Homo sapiens_hsa051451.44308778
28TNF signaling pathway_Homo sapiens_hsa046681.42682944
29Hematopoietic cell lineage_Homo sapiens_hsa046401.41057980
30Influenza A_Homo sapiens_hsa051641.41017442
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39481306
32Pertussis_Homo sapiens_hsa051331.36640486
33Hepatitis B_Homo sapiens_hsa051611.33055076
34Apoptosis_Homo sapiens_hsa042101.28254261
35Graft-versus-host disease_Homo sapiens_hsa053321.28161465
36p53 signaling pathway_Homo sapiens_hsa041151.27746829
37Small cell lung cancer_Homo sapiens_hsa052221.26187880
38Asthma_Homo sapiens_hsa053101.26046104
39Cell cycle_Homo sapiens_hsa041101.20682463
40Malaria_Homo sapiens_hsa051441.20481543
41Spliceosome_Homo sapiens_hsa030401.20374184
42Viral myocarditis_Homo sapiens_hsa054161.15444362
43Staphylococcus aureus infection_Homo sapiens_hsa051501.14815763
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13855656
45Tuberculosis_Homo sapiens_hsa051521.11329793
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10527345
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08642034
48Notch signaling pathway_Homo sapiens_hsa043301.07622551
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06184216
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05446932
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03547537
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03512807
53Nucleotide excision repair_Homo sapiens_hsa034200.99012750
54Pancreatic cancer_Homo sapiens_hsa052120.98267931
55Chemokine signaling pathway_Homo sapiens_hsa040620.97472403
56Salmonella infection_Homo sapiens_hsa051320.96490858
57Viral carcinogenesis_Homo sapiens_hsa052030.95859821
58Platelet activation_Homo sapiens_hsa046110.95743295
59Epstein-Barr virus infection_Homo sapiens_hsa051690.94702234
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93643178
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.92955905
62Lysosome_Homo sapiens_hsa041420.90342221
63Phagosome_Homo sapiens_hsa041450.89926518
64MicroRNAs in cancer_Homo sapiens_hsa052060.87725069
65HTLV-I infection_Homo sapiens_hsa051660.85492156
66Fanconi anemia pathway_Homo sapiens_hsa034600.84763471
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84056143
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.83916511
69Non-homologous end-joining_Homo sapiens_hsa034500.83247138
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83099048
71RNA transport_Homo sapiens_hsa030130.83057607
72Prolactin signaling pathway_Homo sapiens_hsa049170.79956378
73Fatty acid biosynthesis_Homo sapiens_hsa000610.78918346
74One carbon pool by folate_Homo sapiens_hsa006700.78426261
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76824153
76Hepatitis C_Homo sapiens_hsa051600.75434810
77Other glycan degradation_Homo sapiens_hsa005110.74943617
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74128633
79T cell receptor signaling pathway_Homo sapiens_hsa046600.72616044
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69931903
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67550064
82African trypanosomiasis_Homo sapiens_hsa051430.64256518
83RNA degradation_Homo sapiens_hsa030180.63746236
84Autoimmune thyroid disease_Homo sapiens_hsa053200.61487300
85Non-small cell lung cancer_Homo sapiens_hsa052230.59660618
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.59234039
87Insulin resistance_Homo sapiens_hsa049310.56102510
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.55715800
89HIF-1 signaling pathway_Homo sapiens_hsa040660.55512477
90mRNA surveillance pathway_Homo sapiens_hsa030150.55423593
91N-Glycan biosynthesis_Homo sapiens_hsa005100.55401883
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53044637
93mTOR signaling pathway_Homo sapiens_hsa041500.52680150
94Colorectal cancer_Homo sapiens_hsa052100.51102735
95VEGF signaling pathway_Homo sapiens_hsa043700.50140680
96Adherens junction_Homo sapiens_hsa045200.49003339
97Thyroid cancer_Homo sapiens_hsa052160.48436267
98Lysine degradation_Homo sapiens_hsa003100.47705022
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47306356
100Type I diabetes mellitus_Homo sapiens_hsa049400.46898050
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46338407
102Pyrimidine metabolism_Homo sapiens_hsa002400.45774628
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45313713
104Proteoglycans in cancer_Homo sapiens_hsa052050.44934850
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42077049
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41957513
107Pathways in cancer_Homo sapiens_hsa052000.41418778
108Rheumatoid arthritis_Homo sapiens_hsa053230.39947750
109Pentose phosphate pathway_Homo sapiens_hsa000300.39919960
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39718126
111Amoebiasis_Homo sapiens_hsa051460.39093545
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38919990
113Regulation of autophagy_Homo sapiens_hsa041400.38346616
114Caffeine metabolism_Homo sapiens_hsa002320.38055343
115* Dorso-ventral axis formation_Homo sapiens_hsa043200.37393299
116FoxO signaling pathway_Homo sapiens_hsa040680.37366767
117Arachidonic acid metabolism_Homo sapiens_hsa005900.35567605
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.34568584
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34043770
120Prostate cancer_Homo sapiens_hsa052150.33950765
121Inositol phosphate metabolism_Homo sapiens_hsa005620.33612652
122Systemic lupus erythematosus_Homo sapiens_hsa053220.32818725
123Sphingolipid metabolism_Homo sapiens_hsa006000.32527928
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.32464864
125Renal cell carcinoma_Homo sapiens_hsa052110.32151352
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32116533
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28562056
128MAPK signaling pathway_Homo sapiens_hsa040100.28510793
129Ether lipid metabolism_Homo sapiens_hsa005650.28449014
130Choline metabolism in cancer_Homo sapiens_hsa052310.25235038
131Collecting duct acid secretion_Homo sapiens_hsa049660.24412170
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.22830093
133Pancreatic secretion_Homo sapiens_hsa049720.21824888
134Endocytosis_Homo sapiens_hsa041440.21712291

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