EVA1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.18264964
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.18264964
3L-phenylalanine metabolic process (GO:0006558)6.90095400
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.90095400
5aromatic amino acid family catabolic process (GO:0009074)6.58196414
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.33007786
7tryptophan catabolic process (GO:0006569)6.08295918
8indole-containing compound catabolic process (GO:0042436)6.08295918
9indolalkylamine catabolic process (GO:0046218)6.08295918
10kynurenine metabolic process (GO:0070189)5.88704602
11glyoxylate metabolic process (GO:0046487)5.73710299
12bile acid biosynthetic process (GO:0006699)5.71190772
13tryptophan metabolic process (GO:0006568)5.69865062
14regulation of plasminogen activation (GO:0010755)5.65672425
15alpha-linolenic acid metabolic process (GO:0036109)5.61883183
16cysteine metabolic process (GO:0006534)5.54586679
17sulfur amino acid catabolic process (GO:0000098)5.48493686
18high-density lipoprotein particle remodeling (GO:0034375)5.41383039
19serine family amino acid catabolic process (GO:0009071)5.39603630
20urea cycle (GO:0000050)5.28216572
21urea metabolic process (GO:0019627)5.28216572
22negative regulation of fibrinolysis (GO:0051918)5.19686179
23skin morphogenesis (GO:0043589)5.06273529
24regulation of protein activation cascade (GO:2000257)5.01636922
25regulation of fibrinolysis (GO:0051917)5.00594547
26cell adhesion mediated by integrin (GO:0033627)4.98888349
27peptidyl-glutamic acid carboxylation (GO:0017187)4.97829606
28protein carboxylation (GO:0018214)4.97829606
29reverse cholesterol transport (GO:0043691)4.94891155
30regulation of cholesterol esterification (GO:0010872)4.94368828
31homocysteine metabolic process (GO:0050667)4.91075664
32bile acid metabolic process (GO:0008206)4.88497733
33amino-acid betaine metabolic process (GO:0006577)4.88107167
34aromatic amino acid family metabolic process (GO:0009072)4.85563095
35nitrogen cycle metabolic process (GO:0071941)4.85442539
36complement activation, alternative pathway (GO:0006957)4.84612939
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81920574
38lysine catabolic process (GO:0006554)4.76307237
39lysine metabolic process (GO:0006553)4.76307237
40plasma lipoprotein particle remodeling (GO:0034369)4.74518661
41protein-lipid complex remodeling (GO:0034368)4.74518661
42macromolecular complex remodeling (GO:0034367)4.74518661
43alpha-amino acid catabolic process (GO:1901606)4.71233091
44regulation of complement activation (GO:0030449)4.70179668
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.68611033
46regulation of triglyceride catabolic process (GO:0010896)4.63740019
47glycine metabolic process (GO:0006544)4.57682323
48negative regulation of cholesterol transport (GO:0032375)4.56554746
49negative regulation of sterol transport (GO:0032372)4.56554746
50serine family amino acid biosynthetic process (GO:0009070)4.50157393
51serine family amino acid metabolic process (GO:0009069)4.48769316
52tyrosine metabolic process (GO:0006570)4.47087561
53phospholipid efflux (GO:0033700)4.43578289
54cellular ketone body metabolic process (GO:0046950)4.40276754
55cellular amino acid catabolic process (GO:0009063)4.38746594
56low-density lipoprotein particle remodeling (GO:0034374)4.37296042
57glutamate metabolic process (GO:0006536)4.36976625
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.34821664
59cellular biogenic amine catabolic process (GO:0042402)4.31953522
60amine catabolic process (GO:0009310)4.31953522
61acylglycerol homeostasis (GO:0055090)4.30034051
62triglyceride homeostasis (GO:0070328)4.30034051
63cellular modified amino acid catabolic process (GO:0042219)4.28473578
64indolalkylamine metabolic process (GO:0006586)4.23845295
65coenzyme catabolic process (GO:0009109)4.23057747
66cellular glucuronidation (GO:0052695)4.18681464
67dicarboxylic acid biosynthetic process (GO:0043650)4.13122026
68bile acid and bile salt transport (GO:0015721)4.11715241
69ethanol oxidation (GO:0006069)4.07806117
70cholesterol efflux (GO:0033344)4.06749128
71plasma lipoprotein particle clearance (GO:0034381)4.06034833
72endodermal cell differentiation (GO:0035987)4.03560443
73plasma lipoprotein particle assembly (GO:0034377)4.02538292
74imidazole-containing compound metabolic process (GO:0052803)4.01612642
75benzene-containing compound metabolic process (GO:0042537)4.01076718
76intestinal cholesterol absorption (GO:0030299)3.98031462
77drug catabolic process (GO:0042737)3.94736029
78COPI coating of Golgi vesicle (GO:0048205)3.94735344
79Golgi transport vesicle coating (GO:0048200)3.94735344
80regulation of extracellular matrix disassembly (GO:0010715)3.92244242
81negative regulation of protein activation cascade (GO:2000258)3.91959849
82protein retention in ER lumen (GO:0006621)3.91707231
83very-low-density lipoprotein particle assembly (GO:0034379)3.90105404
84arginine metabolic process (GO:0006525)3.89837872
85chondrocyte proliferation (GO:0035988)3.87772827
86hemidesmosome assembly (GO:0031581)3.85769436
87regulation of bile acid biosynthetic process (GO:0070857)3.85661039
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.81082169
89ketone body metabolic process (GO:1902224)3.80733502
90carboxylic acid catabolic process (GO:0046395)3.80520355
91organic acid catabolic process (GO:0016054)3.80520355
92L-serine metabolic process (GO:0006563)3.78108077
93regulation of cholesterol homeostasis (GO:2000188)3.78002630
94short-chain fatty acid metabolic process (GO:0046459)3.77198534
95fibrinolysis (GO:0042730)3.74904969
96glucuronate metabolic process (GO:0019585)3.70592586
97uronic acid metabolic process (GO:0006063)3.70592586
98urate metabolic process (GO:0046415)3.70005551
99acetyl-CoA metabolic process (GO:0006084)3.69560200
100negative regulation of complement activation (GO:0045916)3.69425887
101plasma lipoprotein particle organization (GO:0071827)3.67254958
102phospholipid homeostasis (GO:0055091)3.66612347
103collagen fibril organization (GO:0030199)3.66462865
104heme transport (GO:0015886)3.65949825
105aldehyde catabolic process (GO:0046185)3.63944637
106actin filament depolymerization (GO:0030042)3.62509390
107cholesterol homeostasis (GO:0042632)3.62187299
108carnitine metabolic process (GO:0009437)3.61810499
109complement activation, classical pathway (GO:0006958)3.61304245
110protein-lipid complex assembly (GO:0065005)3.58336439
111sterol homeostasis (GO:0055092)3.57095676
112aspartate family amino acid catabolic process (GO:0009068)3.56213571
113complement activation (GO:0006956)3.55971140
114exogenous drug catabolic process (GO:0042738)3.53257277
115positive regulation of triglyceride lipase activity (GO:0061365)3.51314707
116positive regulation of lipoprotein lipase activity (GO:0051006)3.51314707
117protein activation cascade (GO:0072376)3.51241012
1182-oxoglutarate metabolic process (GO:0006103)3.50992779
119COPII vesicle coating (GO:0048208)3.38490585
120basement membrane organization (GO:0071711)3.36803031
121regulation of metalloenzyme activity (GO:0048552)3.36059945
122negative regulation of coagulation (GO:0050819)3.32726262
123protein maturation by protein folding (GO:0022417)3.31336933
124substrate-dependent cell migration (GO:0006929)3.29938118
125sequestering of extracellular ligand from receptor (GO:0035581)3.26600092
126negative regulation of blood coagulation (GO:0030195)3.23928904
127negative regulation of hemostasis (GO:1900047)3.23928904
128type B pancreatic cell proliferation (GO:0044342)3.18913693
129negative regulation of wound healing (GO:0061045)3.18681843
130wound healing, spreading of epidermal cells (GO:0035313)3.11404704
131endocardial cushion development (GO:0003197)3.08254665
132endothelial cell morphogenesis (GO:0001886)3.04774309
133mesodermal cell differentiation (GO:0048333)3.03597222
134hyaluronan catabolic process (GO:0030214)3.00327308
135positive regulation of extracellular matrix organization (GO:1903055)2.96514802
136cellular response to vitamin (GO:0071295)2.92163908
137kidney mesenchyme development (GO:0072074)2.91130799
138membrane raft organization (GO:0031579)2.90226049
139positive regulation of hemostasis (GO:1900048)2.88992201
140positive regulation of blood coagulation (GO:0030194)2.88992201
141protein heterotrimerization (GO:0070208)2.88678575
142cellular response to vitamin D (GO:0071305)2.88545736
143positive regulation of osteoblast proliferation (GO:0033690)2.88125918
144platelet degranulation (GO:0002576)2.85421769
145cell-substrate junction assembly (GO:0007044)2.84588822
146regulation of extracellular matrix organization (GO:1903053)2.83933097
147protein localization to endosome (GO:0036010)2.83160471
148cell migration involved in sprouting angiogenesis (GO:0002042)2.80776552
149regulation of collagen metabolic process (GO:0010712)2.80169076
150negative regulation of fatty acid transport (GO:2000192)2.77635955
151response to gravity (GO:0009629)2.77137208
152positive regulation of collagen biosynthetic process (GO:0032967)2.76448705
153extracellular fibril organization (GO:0043206)2.75674247
154blood coagulation, intrinsic pathway (GO:0007597)2.75416744
155negative regulation of chondrocyte differentiation (GO:0032331)2.75012451
156regulation of apoptotic cell clearance (GO:2000425)2.72605756
157desmosome organization (GO:0002934)2.71031545
158positive regulation of endothelial cell apoptotic process (GO:2000353)2.70914161
159protein hydroxylation (GO:0018126)2.70830483
160positive regulation of coagulation (GO:0050820)2.68825771
161peptidyl-proline hydroxylation (GO:0019511)2.66468335
162regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.66216484
163regulation of integrin-mediated signaling pathway (GO:2001044)2.64958250
164positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64925932
165apoptotic cell clearance (GO:0043277)2.63726713
166mesenchymal-epithelial cell signaling (GO:0060638)2.56243409
167positive regulation of collagen metabolic process (GO:0010714)2.56096905
168collagen metabolic process (GO:0032963)2.55536533
169nucleotide-sugar biosynthetic process (GO:0009226)2.54207229
170extracellular matrix disassembly (GO:0022617)2.54146469
171wound healing, spreading of cells (GO:0044319)2.53917543
172regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52672461
173heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.52597790
174regulation of transforming growth factor beta1 production (GO:0032908)2.52147236
175muscle cell migration (GO:0014812)2.50826512
176regulation of type B pancreatic cell apoptotic process (GO:2000674)2.50522435
177substrate adhesion-dependent cell spreading (GO:0034446)2.45443749
178negative regulation of humoral immune response (GO:0002921)2.45266455
179omega-hydroxylase P450 pathway (GO:0097267)2.44926109
180retina vasculature morphogenesis in camera-type eye (GO:0061299)2.42616712
181positive regulation of wound healing (GO:0090303)2.41696268
182regulation of endothelial cell apoptotic process (GO:2000351)2.41113092
183UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40909640
184pinocytosis (GO:0006907)2.40358672
185adhesion of symbiont to host cell (GO:0044650)2.39216339
186virion attachment to host cell (GO:0019062)2.39216339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.30187712
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14209115
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.78874650
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.39264528
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.33339418
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.98208941
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.95487542
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.88681322
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85836566
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.85742539
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.22765762
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.79874672
13BRD4_25478319_ChIP-Seq_HGPS_Human2.75818007
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.67498739
15CJUN_26792858_Chip-Seq_BT549_Human2.65497294
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.62662207
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.43275351
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.31740802
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.31740802
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12856503
21ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.12636902
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.10421245
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06873201
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01225290
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8317182
26JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98736069
27JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96825509
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.87129426
29CLOCK_20551151_ChIP-Seq_293T_Human1.85446125
30TP53_18474530_ChIP-ChIP_U2OS_Human1.82955198
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.79473435
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76990406
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.73288340
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70179497
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67711861
36HTT_18923047_ChIP-ChIP_STHdh_Human1.56828839
37ATF3_27146783_Chip-Seq_COLON_Human1.54348079
38TP53_22127205_ChIP-Seq_IMR90_Human1.53550041
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51907787
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.50930653
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50741617
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50056029
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49047536
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.46600036
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.41395134
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36349153
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35693841
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34926927
49TP53_16413492_ChIP-PET_HCT116_Human1.32911949
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32640260
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30984466
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29065173
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27674016
54NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.26847590
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24962187
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24387693
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22582624
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19675999
59GATA1_22025678_ChIP-Seq_K562_Human1.19431402
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16690234
61SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16319057
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15478959
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13341817
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10051005
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09401671
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.09357635
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08052297
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07400530
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.06436536
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.06436536
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06433551
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06374302
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05467438
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04964426
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02645529
76SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01368902
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00878650
78SOX17_20123909_ChIP-Seq_XEN_Mouse0.99878502
79TP53_23651856_ChIP-Seq_MEFs_Mouse0.97961948
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96788535
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95572009
82TP63_23658742_ChIP-Seq_EP156T_Human0.95412508
83ZNF263_19887448_ChIP-Seq_K562_Human0.95239655
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95070501
85KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93787432
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92842878
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92081031
88GATA4_25053715_ChIP-Seq_YYC3_Human0.91691435
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90917268
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89810869
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89501433
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87962164
93SA1_22415368_ChIP-Seq_MEFs_Mouse0.87564596
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84437096
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.82250782
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81005956
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.75066786
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74757244
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72309738
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70157616
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68020927
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67893202
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.65964942
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63825199
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63825199
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63319088
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62779685
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.62568973
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.62250672
110TRIM28_21343339_ChIP-Seq_HEK293_Human0.59253255
111RARB_24833708_ChIP-Seq_LIVER_Mouse0.58498310
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.57443361
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.56126219
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55070334
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54705708
116AR_21909140_ChIP-Seq_LNCAP_Human0.54661856
117AR_20517297_ChIP-Seq_VCAP_Human0.53797270
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.53187226
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.52727532
120CEBPB_22108803_ChIP-Seq_LS180_Human0.52198954
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.51510467
122PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49369044
123MYC_19915707_ChIP-ChIP_AK7_Human0.49188760
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49088950
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.48504256
126TAF2_19829295_ChIP-Seq_ESCs_Human0.48393272
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.47668821
128CBP_21632823_ChIP-Seq_H3396_Human0.47001075
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.46679328
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.46223441
131P53_21459846_ChIP-Seq_SAOS-2_Human0.43971955
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.43427565
133STAT1_17558387_ChIP-Seq_HELA_Human0.43374985
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.43310241
135LXR_22292898_ChIP-Seq_THP-1_Human0.42599416
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41896712
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41803994
138TCF3_18692474_ChIP-Seq_MEFs_Mouse0.41798353
139GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.41524149
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41285176
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40974390
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.40740321
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.39575481
144BCAT_22108803_ChIP-Seq_LS180_Human0.38916571
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.38621666
146NANOG_16518401_ChIP-PET_MESCs_Mouse0.38262469
147FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.37847567
148SOX2_18692474_ChIP-Seq_MEFs_Mouse0.37413198
149GATA6_25053715_ChIP-Seq_YYC3_Human0.36323548
150CDX2_22108803_ChIP-Seq_LS180_Human0.35902562
151LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35780131
152CSB_26484114_Chip-Seq_FIBROBLAST_Human0.35752053
153SOX2_20726797_ChIP-Seq_SW620_Human0.35285446
154RACK7_27058665_Chip-Seq_MCF-7_Human0.35274682
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.35008795
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.34814694
157OCT4_18692474_ChIP-Seq_MEFs_Mouse0.34515999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.20435003
2MP0005360_urolithiasis7.45390175
3MP0005085_abnormal_gallbladder_physiolo6.22708216
4MP0008438_abnormal_cutaneous_collagen6.19594496
5MP0005365_abnormal_bile_salt6.02603277
6MP0008875_abnormal_xenobiotic_pharmacok5.07175926
7MP0003806_abnormal_nucleotide_metabolis4.24875393
8MP0004272_abnormal_basement_membrane4.12397844
9MP0009840_abnormal_foam_cell3.83871260
10MP0003252_abnormal_bile_duct3.69250430
11MP0006054_spinal_hemorrhage3.63646827
12MP0010329_abnormal_lipoprotein_level3.51410333
13MP0005257_abnormal_intraocular_pressure3.47852240
14MP0003950_abnormal_plasma_membrane3.39105350
15MP0005332_abnormal_amino_acid3.16477556
16MP0003566_abnormal_cell_adhesion3.03381047
17MP0001958_emphysema2.89332460
18MP0003195_calcinosis2.74266238
19MP0005083_abnormal_biliary_tract2.71690190
20MP0003279_aneurysm2.71005729
21MP0009780_abnormal_chondrocyte_physiolo2.62181717
22MP0004019_abnormal_vitamin_homeostasis2.49277828
23MP0005503_abnormal_tendon_morphology2.44518661
24MP0001666_abnormal_nutrient_absorption2.44057925
25MP0005275_abnormal_skin_tensile2.39324927
26MP0005023_abnormal_wound_healing2.36298231
27MP0003191_abnormal_cellular_cholesterol2.21192940
28MP0005623_abnormal_meninges_morphology2.11769108
29MP0000609_abnormal_liver_physiology2.08359431
30MP0002118_abnormal_lipid_homeostasis2.06353463
31MP0000013_abnormal_adipose_tissue1.96840213
32MP0002138_abnormal_hepatobiliary_system1.91174442
33MP0005319_abnormal_enzyme/_coenzyme1.81237290
34MP0002060_abnormal_skin_morphology1.75024631
35MP0002877_abnormal_melanocyte_morpholog1.71196227
36MP0003091_abnormal_cell_migration1.70715317
37MP0002254_reproductive_system_inflammat1.69899373
38MP0000767_abnormal_smooth_muscle1.68362060
39MP0003868_abnormal_feces_composition1.67654514
40MP0001764_abnormal_homeostasis1.61980859
41MP0003941_abnormal_skin_development1.61782002
42MP0009697_abnormal_copulation1.56281959
43MP0005451_abnormal_body_composition1.53782049
44MP0005584_abnormal_enzyme/coenzyme_acti1.51587875
45MP0003011_delayed_dark_adaptation1.47127685
46MP0010352_gastrointestinal_tract_polyps1.43514490
47MP0009643_abnormal_urine_homeostasis1.40079295
48MP0003186_abnormal_redox_activity1.39323509
49MP0001879_abnormal_lymphatic_vessel1.36003735
50MP0010030_abnormal_orbit_morphology1.35137223
51MP0002896_abnormal_bone_mineralization1.33231728
52MP0000534_abnormal_ureter_morphology1.29065018
53MP0001915_intracranial_hemorrhage1.26461008
54MP0000003_abnormal_adipose_tissue1.25631801
55MP0005647_abnormal_sex_gland1.25588977
56MP0001299_abnormal_eye_distance/1.25496180
57MP0003705_abnormal_hypodermis_morpholog1.22695652
58MP0005197_abnormal_uvea_morphology1.22232219
59MP0005508_abnormal_skeleton_morphology1.21319660
60MP0000604_amyloidosis1.20737350
61MP0005409_darkened_coat_color1.17230474
62MP0010386_abnormal_urinary_bladder1.16343173
63MP0005171_absent_coat_pigmentation1.16086157
64MP0000762_abnormal_tongue_morphology1.10875861
65MP0000598_abnormal_liver_morphology1.10195912
66MP0003656_abnormal_erythrocyte_physiolo1.04931364
67MP0003329_amyloid_beta_deposits1.04723030
68MP0003690_abnormal_glial_cell1.03413016
69MP0009764_decreased_sensitivity_to1.00007207
70MP0005670_abnormal_white_adipose0.97440178
71MP0005636_abnormal_mineral_homeostasis0.97206533
72MP0010368_abnormal_lymphatic_system0.95515334
73MP0002089_abnormal_postnatal_growth/wei0.95305609
74MP0005165_increased_susceptibility_to0.93305340
75MP0002282_abnormal_trachea_morphology0.93115015
76MP0003942_abnormal_urinary_system0.90497468
77MP0001849_ear_inflammation0.88909498
78MP0003385_abnormal_body_wall0.88049156
79MP0009763_increased_sensitivity_to0.86722957
80MP0009250_abnormal_appendicular_skeleto0.83985020
81MP0005084_abnormal_gallbladder_morpholo0.83869508
82MP0001661_extended_life_span0.82650029
83MP0003718_maternal_effect0.81920722
84MP0009642_abnormal_blood_homeostasis0.81600624
85MP0002933_joint_inflammation0.81102943
86MP0001756_abnormal_urination0.80625327
87MP0009053_abnormal_anal_canal0.79538304
88MP0000733_abnormal_muscle_development0.79031314
89MP0005376_homeostasis/metabolism_phenot0.78750394
90MP0002128_abnormal_blood_circulation0.78139360
91MP0005193_abnormal_anterior_eye0.77134108
92MP0006036_abnormal_mitochondrial_physio0.76324470
93MP0005408_hypopigmentation0.76010120
94MP0008469_abnormal_protein_level0.75413143
95MP0001614_abnormal_blood_vessel0.74653242
96MP0000163_abnormal_cartilage_morphology0.74391980
97MP0009384_cardiac_valve_regurgitation0.73157499
98MP0000751_myopathy0.72878020
99MP0002971_abnormal_brown_adipose0.72806129
100MP0000858_altered_metastatic_potential0.69749923
101MP0001348_abnormal_lacrimal_gland0.67405394
102MP0003172_abnormal_lysosome_physiology0.67378702
103MP0002876_abnormal_thyroid_physiology0.65954435
104MP0005395_other_phenotype0.65595568
105MP0002108_abnormal_muscle_morphology0.65409953
106MP0000749_muscle_degeneration0.65308410
107MP0002078_abnormal_glucose_homeostasis0.64297984
108MP0004134_abnormal_chest_morphology0.62396237
109MP0005390_skeleton_phenotype0.61953761
110MP0000467_abnormal_esophagus_morphology0.61689025
111MP0010234_abnormal_vibrissa_follicle0.61303580
112MP0003283_abnormal_digestive_organ0.60532691
113MP0005266_abnormal_metabolism0.60163600
114MP0004130_abnormal_muscle_cell0.59808646
115MP0002136_abnormal_kidney_physiology0.59741822
116MP0009765_abnormal_xenobiotic_induced0.59150628
117MP0005535_abnormal_body_temperature0.58821417
118MP0002938_white_spotting0.58750463
119MP0005334_abnormal_fat_pad0.58413878
120MP0000371_diluted_coat_color0.57831705
121MP0005220_abnormal_exocrine_pancreas0.56709995
122MP0000639_abnormal_adrenal_gland0.55943479
123MP0002113_abnormal_skeleton_development0.55635690
124MP0002177_abnormal_outer_ear0.55116941
125MP0001270_distended_abdomen0.54650378
126MP0001853_heart_inflammation0.54178598
127MP0003638_abnormal_response/metabolism_0.52697314
128MP0002115_abnormal_skeleton_extremities0.52673772
129MP0006035_abnormal_mitochondrial_morpho0.51799655
130MP0003075_altered_response_to0.51699679
131MP0006138_congestive_heart_failure0.51406176
132MP0004233_abnormal_muscle_weight0.51189246
133MP0004858_abnormal_nervous_system0.51064507
134MP0000538_abnormal_urinary_bladder0.50931465
135MP0002796_impaired_skin_barrier0.50279699
136MP0005166_decreased_susceptibility_to0.45051040
137MP0004043_abnormal_pH_regulation0.44776780
138MP0000579_abnormal_nail_morphology0.44297548
139MP0005666_abnormal_adipose_tissue0.44026150
140MP0009672_abnormal_birth_weight0.41568306
141MP0004782_abnormal_surfactant_physiolog0.41285185
142MP0004883_abnormal_blood_vessel0.40298283
143MP0005248_abnormal_Harderian_gland0.38620130
144MP0005058_abnormal_lysosome_morphology0.38436401
145MP0005448_abnormal_energy_balance0.38280463
146MP0000230_abnormal_systemic_arterial0.36925838
147MP0003953_abnormal_hormone_level0.36696733
148MP0002168_other_aberrant_phenotype0.36524299
149MP0008874_decreased_physiological_sensi0.36469895
150MP0005595_abnormal_vascular_smooth0.36035811
151MP0001881_abnormal_mammary_gland0.35231045
152MP0001542_abnormal_bone_strength0.35051880
153MP0000647_abnormal_sebaceous_gland0.33784610
154MP0009115_abnormal_fat_cell0.33324064
155MP0004381_abnormal_hair_follicle0.32167865
156MP0002928_abnormal_bile_duct0.30439430
157MP0005164_abnormal_response_to0.30404061
158MP0008873_increased_physiological_sensi0.30133139
159MP0008872_abnormal_physiological_respon0.29827796
160MP0000566_synostosis0.29688374
161MP0002135_abnormal_kidney_morphology0.27489623
162MP0000249_abnormal_blood_vessel0.26899328
163MP0005464_abnormal_platelet_physiology0.26449812
164MP0002090_abnormal_vision0.25790309
165MP0002295_abnormal_pulmonary_circulatio0.25369732
166MP0005187_abnormal_penis_morphology0.25173655
167MP0001243_abnormal_dermal_layer0.24540821

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.06855415
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.99798327
3Intrahepatic cholestasis (HP:0001406)6.98396055
4Deep venous thrombosis (HP:0002625)6.89360766
5Protrusio acetabuli (HP:0003179)6.51215441
6Xanthomatosis (HP:0000991)6.45431501
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.36112593
8Hypobetalipoproteinemia (HP:0003563)6.19973441
9Prolonged partial thromboplastin time (HP:0003645)6.09403862
10Hyperlipoproteinemia (HP:0010980)5.80680111
11Hyperglycinemia (HP:0002154)4.99236211
12Complement deficiency (HP:0004431)4.95604232
13Hypolipoproteinemia (HP:0010981)4.90654292
14Hyperammonemia (HP:0001987)4.82534212
15Hyperglycinuria (HP:0003108)4.79297460
16Abnormality of serine family amino acid metabolism (HP:0010894)4.63416664
17Abnormality of glycine metabolism (HP:0010895)4.63416664
18Hypoalphalipoproteinemia (HP:0003233)4.49407486
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42900185
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.34297569
21Joint hemorrhage (HP:0005261)4.30712079
22Ketosis (HP:0001946)4.29011949
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.27116720
24Epidermoid cyst (HP:0200040)4.24842952
25Abnormality of methionine metabolism (HP:0010901)4.22921799
26Abnormality of aspartate family amino acid metabolism (HP:0010899)4.19272845
27Aortic dissection (HP:0002647)4.10261992
28Atrophic scars (HP:0001075)4.03146974
29Abnormality of the common coagulation pathway (HP:0010990)3.96418565
30Fat malabsorption (HP:0002630)3.92590451
31Hypoglycemic coma (HP:0001325)3.87512149
32Vascular tortuosity (HP:0004948)3.79612012
33Abnormality of pyrimidine metabolism (HP:0004353)3.65188920
34Abnormality of fatty-acid metabolism (HP:0004359)3.57405555
35Arterial tortuosity (HP:0005116)3.54726970
36Vertebral compression fractures (HP:0002953)3.51639364
37Abnormality of complement system (HP:0005339)3.51608421
38Ankle contracture (HP:0006466)3.49991292
39Follicular hyperkeratosis (HP:0007502)3.47326923
40Abnormality of the intrinsic pathway (HP:0010989)3.46830969
41Hypercholesterolemia (HP:0003124)3.46154761
42Conjugated hyperbilirubinemia (HP:0002908)3.45267540
43Aortic aneurysm (HP:0004942)3.42997970
44Abnormality of serum amino acid levels (HP:0003112)3.42393622
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36982463
46Abnormality of dentin (HP:0010299)3.36332815
47Soft skin (HP:0000977)3.27811158
48Wormian bones (HP:0002645)3.27736967
49Gout (HP:0001997)3.26698234
50Delayed CNS myelination (HP:0002188)3.24889483
51Abnormality of nucleobase metabolism (HP:0010932)3.15794923
52Ketoacidosis (HP:0001993)3.14789425
53Hyperbilirubinemia (HP:0002904)3.05382480
54Cervical subluxation (HP:0003308)3.03695812
55Steatorrhea (HP:0002570)3.00614557
56Fragile skin (HP:0001030)2.95028830
57Blue sclerae (HP:0000592)2.92137448
58Spinal rigidity (HP:0003306)2.92073931
59Abnormality of purine metabolism (HP:0004352)2.91097924
60Myocardial infarction (HP:0001658)2.90769154
61Neonatal short-limb short stature (HP:0008921)2.85315839
62Lethargy (HP:0001254)2.83838857
63Bladder diverticulum (HP:0000015)2.83467953
64Dicarboxylic aciduria (HP:0003215)2.80897901
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80897901
66Metabolic acidosis (HP:0001942)2.78847677
67Hepatocellular carcinoma (HP:0001402)2.76519160
68Peritonitis (HP:0002586)2.67185713
69Spontaneous abortion (HP:0005268)2.66995716
70Slender build (HP:0001533)2.66660054
71Skin nodule (HP:0200036)2.65932803
72Abnormality of the acetabulum (HP:0003170)2.65895377
73Vascular calcification (HP:0004934)2.64986272
74Abnormal delivery (HP:0001787)2.59093676
75Osteolytic defects of the hand bones (HP:0009699)2.56150368
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.56150368
77Irritability (HP:0000737)2.53713716
78Systemic lupus erythematosus (HP:0002725)2.51483762
79Hypochromic microcytic anemia (HP:0004840)2.47116457
80Abnormality of carpal bone ossification (HP:0006257)2.47075046
81Hypoglycemic seizures (HP:0002173)2.43735293
82Menorrhagia (HP:0000132)2.42980602
83Malnutrition (HP:0004395)2.38744876
84Ulnar bowing (HP:0003031)2.38206911
85Abnormality of the Achilles tendon (HP:0005109)2.37276214
86Biconcave vertebral bodies (HP:0004586)2.37094094
87Spastic diplegia (HP:0001264)2.36263557
88Shallow orbits (HP:0000586)2.35233302
89Cardiovascular calcification (HP:0011915)2.34215841
90Sensorimotor neuropathy (HP:0007141)2.31343463
91Elbow flexion contracture (HP:0002987)2.29638942
92Cerebral edema (HP:0002181)2.29454299
93Enlarged kidneys (HP:0000105)2.29223669
94Dilatation of the ascending aorta (HP:0005111)2.27747942
95Esophageal varix (HP:0002040)2.26751974
96Late onset (HP:0003584)2.26275945
97Short nail (HP:0001799)2.24106541
98Acanthocytosis (HP:0001927)2.23582508
99Brushfield spots (HP:0001088)2.22718272
100Amyloidosis (HP:0011034)2.22244220
101Type 1 muscle fiber predominance (HP:0003803)2.22061049
102Spondylolisthesis (HP:0003302)2.21969901
103Generalized amyotrophy (HP:0003700)2.21446941
104Neonatal onset (HP:0003623)2.21110962
105Generalized aminoaciduria (HP:0002909)2.19651847
106Mitral stenosis (HP:0001718)2.17208633
107Joint stiffness (HP:0001387)2.15417562
108Wrist flexion contracture (HP:0001239)2.15342995
109Cerebral aneurysm (HP:0004944)2.15310247
110Vomiting (HP:0002013)2.15256941
111Mitral regurgitation (HP:0001653)2.14239931
112Nonimmune hydrops fetalis (HP:0001790)2.12690755
113Hyperuricemia (HP:0002149)2.12599502
114Increased purine levels (HP:0004368)2.12599502
115Glomerulonephritis (HP:0000099)2.12469116
116Coxa vara (HP:0002812)2.12451198
117Glucose intolerance (HP:0000833)2.12366230
118Back pain (HP:0003418)2.12177328
119Mucopolysacchariduria (HP:0008155)2.11447928
120Urinary glycosaminoglycan excretion (HP:0003541)2.11447928
121Abnormality of proline metabolism (HP:0010907)2.11319699
122Hydroxyprolinuria (HP:0003080)2.11319699
123Abnormal gallbladder morphology (HP:0012437)2.10870053
124Distal upper limb amyotrophy (HP:0007149)2.09069965
125Upper limb amyotrophy (HP:0009129)2.09069965
126Abnormal ossification of hand bones (HP:0005921)2.08801063
127Confusion (HP:0001289)2.07794159
128Natal tooth (HP:0000695)2.07404359
129Hyperextensible skin (HP:0000974)2.07305292
130Cholelithiasis (HP:0001081)2.06760102
131Achilles tendon contracture (HP:0001771)2.06082899
132Genu recurvatum (HP:0002816)2.05619456
133Ovoid vertebral bodies (HP:0003300)2.04976644
134Delayed closure of the anterior fontanelle (HP:0001476)2.04908544
135Alkalosis (HP:0001948)2.04749495
136Pancreatitis (HP:0001733)2.04472824
137Proximal tubulopathy (HP:0000114)2.03832068
138Round ear (HP:0100830)2.03455874
139Aortic regurgitation (HP:0001659)2.03397438
140Broad metatarsal (HP:0001783)2.03141129
141Mitral valve prolapse (HP:0001634)2.02919217
142Status epilepticus (HP:0002133)2.00452534
143Abnormality of polysaccharide metabolism (HP:0011012)1.97768001
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97768001
145Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97768001
146Opisthotonus (HP:0002179)1.97579131
147Rickets (HP:0002748)1.95828333
148Orthostatic hypotension (HP:0001278)1.94902985
149Protruding ear (HP:0000411)1.93811149
150Hyperinsulinemic hypoglycemia (HP:0000825)1.91409148
151Joint laxity (HP:0001388)1.91405761
152Hand muscle atrophy (HP:0009130)1.90803410
153Striae distensae (HP:0001065)1.90562629
154Abnormal cartilage morphology (HP:0002763)1.89812972
155Renal cortical cysts (HP:0000803)1.89560438
156Mildly elevated creatine phosphokinase (HP:0008180)1.89176322
157Abnormal gallbladder physiology (HP:0012438)1.89153826
158Cholecystitis (HP:0001082)1.89153826
159Thrombophlebitis (HP:0004418)1.88537099
160Aortic valve stenosis (HP:0001650)1.88096099
161Delayed gross motor development (HP:0002194)1.87272221
162Abnormal hand bone ossification (HP:0010660)1.85664628
163Long toe (HP:0010511)1.84178209
164Hyperglycemia (HP:0003074)1.84167258
165Reduced subcutaneous adipose tissue (HP:0003758)1.84113987
166Hemorrhage of the eye (HP:0011885)1.84084863
167Wide anterior fontanel (HP:0000260)1.83982206
168Spastic paraparesis (HP:0002313)1.83564744
169Abnormality of urine glucose concentration (HP:0011016)1.83447101
170Glycosuria (HP:0003076)1.83447101
171Abnormal enzyme/coenzyme activity (HP:0012379)1.83429037
172Aneurysm (HP:0002617)1.81876154
173Entropion (HP:0000621)1.80876111
174Recurrent gram-negative bacterial infections (HP:0005420)1.80721328
175Abnormality of transition element cation homeostasis (HP:0011030)1.78316651
176Abnormality of vitamin metabolism (HP:0100508)1.78253012
177Arthropathy (HP:0003040)1.76085661
178Osteoarthritis (HP:0002758)1.73883415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.30073682
2SIK14.55463303
3FGFR44.13886109
4ERN13.86825971
5MYLK3.75671501
6LIMK13.38820053
7TESK13.19675286
8PDGFRA2.91242172
9EPHA42.82540630
10ERBB42.71252273
11PAK42.58763268
12NTRK12.43842474
13TRIB32.43596941
14INSRR2.43276504
15MST1R2.17034018
16TTN2.09313678
17MAP3K122.02620520
18DDR21.86974889
19MAP2K41.84496091
20STK38L1.84223373
21TAOK31.83147760
22EPHB21.82564630
23MAPK111.77268418
24TRPM71.73729082
25LATS11.69090681
26PAK21.66564461
27IRAK31.58782094
28MOS1.56522933
29EPHA21.53091560
30KDR1.52288250
31ABL21.51066378
32PIK3CG1.49988819
33FGFR21.45610857
34PKN21.40543586
35ARAF1.40291655
36PINK11.38571131
37FRK1.38400009
38MAPK121.38311034
39TAOK21.37716952
40TIE11.37406943
41PDK41.36461609
42PDK31.36461609
43PTK2B1.32646665
44NEK91.32598955
45MAP3K31.32584247
46PLK21.30865962
47PDK21.29803087
48PRKG21.24657143
49PTK61.23500609
50TYK21.18369758
51PRKD21.15386399
52ILK1.11613592
53ICK1.10527394
54PRKAA21.10137020
55CDK81.08490508
56FLT31.02349149
57MAP2K30.99428432
58DAPK20.98880604
59GRK60.97547777
60PIM20.96572311
61MET0.96374981
62MAPK40.95246107
63EIF2AK10.95045230
64SGK30.94726847
65ERBB20.94488037
66LATS20.94221795
67SGK20.93921856
68LMTK20.93917647
69FER0.92236056
70ROCK10.90040590
71MAPK70.87942399
72JAK20.85538884
73PRKCZ0.85344630
74PAK60.84881637
75NME20.82100230
76ROCK20.80743009
77PDGFRB0.80522843
78MAP3K70.77700342
79AKT30.75556384
80PRKACG0.75060026
81MAP3K110.74870454
82CAMK2G0.74355786
83PRKAA10.74191109
84SGK4940.72223188
85SGK2230.72223188
86CDC42BPA0.70351001
87WNK30.66963834
88WNK40.66036134
89CDK60.65734672
90BMX0.65092239
91DAPK30.65038313
92EPHB10.63634377
93MAP2K60.63238565
94PDPK10.62612486
95GSK3A0.61408952
96PTK20.60061550
97ERBB30.59961790
98NEK10.59419850
99BRSK10.58277421
100TGFBR20.57796343
101MAPK150.57465795
102MAPKAPK30.56868115
103PRKCG0.56305357
104IGF1R0.54546618
105TBK10.54375938
106BUB10.54052143
107MAP3K20.54011318
108STK100.53344917
109SCYL20.53109491
110PRKCE0.52222586
111MAP3K90.52074729
112EPHA30.51386035
113STK30.51105454
114MAP2K10.51050191
115BRSK20.50513965
116CDK40.49370397
117MAP3K50.49061901
118ADRBK10.47217245
119JAK10.46819385
120PAK10.45960966
121MAP3K140.45807270
122MAP3K60.45212990
123FGFR30.44891791
124PRKCI0.43727992
125PBK0.42764974
126PHKG20.41467907
127PHKG10.41467907
128MAPKAPK20.41245971
129EIF2AK30.40776437
130CAMK2D0.40300453
131CSNK1G10.39747049
132IRAK20.37969494
133GRK10.37377642
134RPS6KA20.36191726
135IRAK10.34331068
136CDK70.34161181
137PRKCA0.33490426
138RIPK10.32186251
139DYRK1B0.32170205
140DAPK10.32109587
141MTOR0.31321390
142SRC0.30812100
143FGFR10.30354982
144MAP2K20.30291985
145MAP3K100.29681749
146MAP3K80.28759381
147PAK30.28424751
148PRKCQ0.27853599
149PDK10.27632153
150STK380.27530576
151AKT20.27268327
152STK160.24550982
153NUAK10.24233308
154CSK0.24145481
155EGFR0.22061784

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.23235533
2Nitrogen metabolism_Homo sapiens_hsa009103.93261929
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20050990
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06995356
5ECM-receptor interaction_Homo sapiens_hsa045123.02950161
6Arginine biosynthesis_Homo sapiens_hsa002202.96230970
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71312802
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68420549
9Fatty acid degradation_Homo sapiens_hsa000712.66283655
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65521940
11Tryptophan metabolism_Homo sapiens_hsa003802.60053776
12Complement and coagulation cascades_Homo sapiens_hsa046102.54356441
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46709950
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.31682781
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23095316
16Butanoate metabolism_Homo sapiens_hsa006502.19816969
17Peroxisome_Homo sapiens_hsa041462.15257083
18Other glycan degradation_Homo sapiens_hsa005112.06304479
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05374930
20Focal adhesion_Homo sapiens_hsa045102.04388367
21Propanoate metabolism_Homo sapiens_hsa006402.00264735
22Fatty acid metabolism_Homo sapiens_hsa012121.98328057
23PPAR signaling pathway_Homo sapiens_hsa033201.93447258
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88451049
25Chemical carcinogenesis_Homo sapiens_hsa052041.87760399
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.80905822
27Histidine metabolism_Homo sapiens_hsa003401.80819717
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77942321
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72426545
30beta-Alanine metabolism_Homo sapiens_hsa004101.71961639
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.70470554
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69045264
33Caffeine metabolism_Homo sapiens_hsa002321.68989773
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65262608
35Retinol metabolism_Homo sapiens_hsa008301.64933778
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60527262
37N-Glycan biosynthesis_Homo sapiens_hsa005101.58831106
38Bile secretion_Homo sapiens_hsa049761.52795735
39Selenocompound metabolism_Homo sapiens_hsa004501.49542918
40Staphylococcus aureus infection_Homo sapiens_hsa051501.46907727
41Vitamin B6 metabolism_Homo sapiens_hsa007501.46101246
42Phenylalanine metabolism_Homo sapiens_hsa003601.43294970
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40683390
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.36294629
45Sulfur metabolism_Homo sapiens_hsa009201.35259077
46Fatty acid elongation_Homo sapiens_hsa000621.34224109
47Pyruvate metabolism_Homo sapiens_hsa006201.33431590
48Tyrosine metabolism_Homo sapiens_hsa003501.31446873
49Proteoglycans in cancer_Homo sapiens_hsa052051.29781306
50Biosynthesis of amino acids_Homo sapiens_hsa012301.27650099
51Folate biosynthesis_Homo sapiens_hsa007901.27440113
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27009907
53Steroid biosynthesis_Homo sapiens_hsa001001.24648099
54Starch and sucrose metabolism_Homo sapiens_hsa005001.22985625
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21830668
56Carbon metabolism_Homo sapiens_hsa012001.20046287
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13931815
58Protein digestion and absorption_Homo sapiens_hsa049741.13162492
59Vibrio cholerae infection_Homo sapiens_hsa051101.12799589
60Arginine and proline metabolism_Homo sapiens_hsa003301.10103148
61ABC transporters_Homo sapiens_hsa020101.09378595
62Small cell lung cancer_Homo sapiens_hsa052221.09341877
63Fat digestion and absorption_Homo sapiens_hsa049751.06392890
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.05739529
65Vitamin digestion and absorption_Homo sapiens_hsa049771.05306305
66Amoebiasis_Homo sapiens_hsa051461.01916468
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99552335
68Sulfur relay system_Homo sapiens_hsa041220.98965058
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95822345
70Adherens junction_Homo sapiens_hsa045200.93408217
71Fatty acid biosynthesis_Homo sapiens_hsa000610.91994927
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91268336
73Protein export_Homo sapiens_hsa030600.88213021
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85645373
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85550792
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83971779
77Sphingolipid metabolism_Homo sapiens_hsa006000.82339989
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82023220
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.81755592
80TGF-beta signaling pathway_Homo sapiens_hsa043500.79966802
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79310546
82Glutathione metabolism_Homo sapiens_hsa004800.78446279
83Lysine degradation_Homo sapiens_hsa003100.74515287
84Glycerolipid metabolism_Homo sapiens_hsa005610.74272241
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73798300
86Pentose phosphate pathway_Homo sapiens_hsa000300.73798091
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73617260
88One carbon pool by folate_Homo sapiens_hsa006700.70022429
89Hippo signaling pathway_Homo sapiens_hsa043900.68081400
90Dilated cardiomyopathy_Homo sapiens_hsa054140.67606197
91Pertussis_Homo sapiens_hsa051330.65415249
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60068360
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56927960
94Shigellosis_Homo sapiens_hsa051310.52997130
95Metabolic pathways_Homo sapiens_hsa011000.51017706
96Fructose and mannose metabolism_Homo sapiens_hsa000510.43329505
97p53 signaling pathway_Homo sapiens_hsa041150.42657276
98Melanoma_Homo sapiens_hsa052180.41379625
99Proteasome_Homo sapiens_hsa030500.39695786
100MicroRNAs in cancer_Homo sapiens_hsa052060.38395452
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.37938862
102Tight junction_Homo sapiens_hsa045300.37925325
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.35029164
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32415328
105Prion diseases_Homo sapiens_hsa050200.32077093
106Galactose metabolism_Homo sapiens_hsa000520.30296763
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.26077143
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26029576
109Linoleic acid metabolism_Homo sapiens_hsa005910.25612381
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24560994
111Insulin resistance_Homo sapiens_hsa049310.18596041
112Glucagon signaling pathway_Homo sapiens_hsa049220.08478156
113Regulation of autophagy_Homo sapiens_hsa041400.07454408
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06440155
115AMPK signaling pathway_Homo sapiens_hsa041520.01135527
116Bladder cancer_Homo sapiens_hsa05219-0.2209870
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2117138
118Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2094797
119Hepatitis C_Homo sapiens_hsa05160-0.2044616
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1986271
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1938294
122Lysosome_Homo sapiens_hsa04142-0.1858666
123African trypanosomiasis_Homo sapiens_hsa05143-0.1538706
124Ether lipid metabolism_Homo sapiens_hsa00565-0.1500879
125Circadian rhythm_Homo sapiens_hsa04710-0.1476918
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1431269
127Insulin signaling pathway_Homo sapiens_hsa04910-0.1388555
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1368983
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1276546
130Renin-angiotensin system_Homo sapiens_hsa04614-0.1272042
131Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0965699
132Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0895344
133Mineral absorption_Homo sapiens_hsa04978-0.0664445
134Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0342674

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