

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | adhesion of symbiont to host cell (GO:0044650) | 5.43473887 |
| 2 | virion attachment to host cell (GO:0019062) | 5.43473887 |
| 3 | COPI coating of Golgi vesicle (GO:0048205) | 5.10167448 |
| 4 | Golgi transport vesicle coating (GO:0048200) | 5.10167448 |
| 5 | adhesion of symbiont to host (GO:0044406) | 4.85678136 |
| 6 | ribosomal small subunit assembly (GO:0000028) | 4.32045132 |
| 7 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.16426629 |
| 8 | viral transcription (GO:0019083) | 4.13911331 |
| 9 | basement membrane organization (GO:0071711) | 4.13190911 |
| 10 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 4.06575655 |
| 11 | protein targeting to ER (GO:0045047) | 4.05293688 |
| 12 | cotranslational protein targeting to membrane (GO:0006613) | 4.00482935 |
| 13 | translational termination (GO:0006415) | 3.99530913 |
| 14 | protein heterotrimerization (GO:0070208) | 3.89993061 |
| 15 | protein retention in ER lumen (GO:0006621) | 3.87867797 |
| 16 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.83788437 |
| 17 | tooth mineralization (GO:0034505) | 3.77786411 |
| 18 | protein localization to endoplasmic reticulum (GO:0070972) | 3.75949224 |
| 19 | pinocytosis (GO:0006907) | 3.58122633 |
| 20 | hyaluronan catabolic process (GO:0030214) | 3.53714511 |
| 21 | protein localization to endosome (GO:0036010) | 3.51329247 |
| 22 | endothelial tube morphogenesis (GO:0061154) | 3.51200920 |
| 23 | morphogenesis of an endothelium (GO:0003159) | 3.51200920 |
| 24 | translational elongation (GO:0006414) | 3.50224295 |
| 25 | extracellular fibril organization (GO:0043206) | 3.37670213 |
| 26 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.37300921 |
| 27 | collagen catabolic process (GO:0030574) | 3.35054574 |
| 28 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.29917651 |
| 29 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.29917651 |
| 30 | stress fiber assembly (GO:0043149) | 3.26959852 |
| 31 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 3.26201470 |
| 32 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.24554072 |
| 33 | negative regulation of smooth muscle cell migration (GO:0014912) | 3.21867727 |
| 34 | blood vessel maturation (GO:0001955) | 3.16838952 |
| 35 | viral life cycle (GO:0019058) | 3.16107892 |
| 36 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 3.11608868 |
| 37 | glial cell migration (GO:0008347) | 3.10361366 |
| 38 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.09225114 |
| 39 | type B pancreatic cell proliferation (GO:0044342) | 3.08732191 |
| 40 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 3.08375319 |
| 41 | multicellular organismal catabolic process (GO:0044243) | 3.07748989 |
| 42 | mannose metabolic process (GO:0006013) | 3.07443821 |
| 43 | regulation of early endosome to late endosome transport (GO:2000641) | 3.06091830 |
| 44 | wound healing, spreading of epidermal cells (GO:0035313) | 3.03848068 |
| 45 | response to interferon-alpha (GO:0035455) | 3.01712949 |
| 46 | venous blood vessel morphogenesis (GO:0048845) | 2.99898785 |
| 47 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.99800080 |
| 48 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.98565777 |
| 49 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.98166902 |
| 50 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.97926954 |
| 51 | extracellular matrix assembly (GO:0085029) | 2.97301141 |
| 52 | regulation of mononuclear cell migration (GO:0071675) | 2.92697529 |
| 53 | translational initiation (GO:0006413) | 2.92659789 |
| 54 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.91679231 |
| 55 | UV protection (GO:0009650) | 2.88993734 |
| 56 | multicellular organismal metabolic process (GO:0044236) | 2.88633446 |
| 57 | cellular protein complex disassembly (GO:0043624) | 2.88430647 |
| 58 | extracellular matrix disassembly (GO:0022617) | 2.88142464 |
| 59 | angiogenesis involved in wound healing (GO:0060055) | 2.88109413 |
| 60 | endodermal cell differentiation (GO:0035987) | 2.86060717 |
| 61 | collagen fibril organization (GO:0030199) | 2.85901646 |
| 62 | protein targeting to membrane (GO:0006612) | 2.85830851 |
| 63 | regulation of extracellular matrix disassembly (GO:0010715) | 2.85141048 |
| 64 | substrate-dependent cell migration (GO:0006929) | 2.81699659 |
| 65 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.80991028 |
| 66 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 2.80155990 |
| 67 | ribosomal small subunit biogenesis (GO:0042274) | 2.78185240 |
| 68 | response to magnesium ion (GO:0032026) | 2.76165866 |
| 69 | negative regulation of glycoprotein biosynthetic process (GO:0010561) | 2.73942459 |
| 70 | response to interferon-beta (GO:0035456) | 2.73336932 |
| 71 | signal peptide processing (GO:0006465) | 2.72678912 |
| 72 | cellular response to vitamin D (GO:0071305) | 2.72252836 |
| 73 | positive regulation of nuclease activity (GO:0032075) | 2.72036722 |
| 74 | regulation of monocyte chemotaxis (GO:0090025) | 2.69822151 |
| 75 | positive regulation of receptor recycling (GO:0001921) | 2.69815694 |
| 76 | polarized epithelial cell differentiation (GO:0030859) | 2.69665567 |
| 77 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.69160225 |
| 78 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.68571962 |
| 79 | maternal placenta development (GO:0001893) | 2.66882422 |
| 80 | positive regulation of extracellular matrix organization (GO:1903055) | 2.65062590 |
| 81 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.64556218 |
| 82 | cell proliferation involved in metanephros development (GO:0072203) | 2.64483527 |
| 83 | maturation of SSU-rRNA (GO:0030490) | 2.64355164 |
| 84 | protein maturation by protein folding (GO:0022417) | 2.64339537 |
| 85 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 2.63924606 |
| 86 | keratan sulfate catabolic process (GO:0042340) | 2.63106494 |
| 87 | sequestering of extracellular ligand from receptor (GO:0035581) | 2.62286778 |
| 88 | cell migration involved in heart development (GO:0060973) | 2.61712631 |
| 89 | apoptotic cell clearance (GO:0043277) | 2.61665570 |
| 90 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.59634990 |
| 91 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 2.59272200 |
| 92 | COPII vesicle coating (GO:0048208) | 2.57821793 |
| 93 | chondroitin sulfate biosynthetic process (GO:0030206) | 2.57203491 |
| 94 | barbed-end actin filament capping (GO:0051016) | 2.56686038 |
| 95 | negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948) | 2.55305869 |
| 96 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 2.54827772 |
| 97 | protein complex disassembly (GO:0043241) | 2.54768035 |
| 98 | skin morphogenesis (GO:0043589) | 2.54455910 |
| 99 | T cell apoptotic process (GO:0070231) | 2.54313246 |
| 100 | regulation of nuclease activity (GO:0032069) | 2.51475606 |
| 101 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.51077675 |
| 102 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.51074384 |
| 103 | positive regulation of vasculogenesis (GO:2001214) | 2.51010818 |
| 104 | phagocytosis, engulfment (GO:0006911) | 2.50865005 |
| 105 | amino sugar catabolic process (GO:0046348) | 2.50485454 |
| 106 | response to peptidoglycan (GO:0032494) | 2.50054852 |
| 107 | negative regulation of adherens junction organization (GO:1903392) | 2.49424777 |
| 108 | negative regulation of focal adhesion assembly (GO:0051895) | 2.49424777 |
| 109 | negative regulation of cell junction assembly (GO:1901889) | 2.49424777 |
| 110 | mature B cell differentiation involved in immune response (GO:0002313) | 2.49377872 |
| 111 | endoplasmic reticulum unfolded protein response (GO:0030968) | 2.49216461 |
| 112 | chondrocyte proliferation (GO:0035988) | 2.49100111 |
| 113 | positive regulation of epithelial to mesenchymal transition (GO:0010718) | 2.48900041 |
| 114 | fibril organization (GO:0097435) | 2.48813983 |
| 115 | endothelium development (GO:0003158) | 2.48599829 |
| 116 | endothelial cell chemotaxis (GO:0035767) | 2.47399178 |
| 117 | cellular response to vitamin (GO:0071295) | 2.47323744 |
| 118 | negative regulation of blood vessel endothelial cell migration (GO:0043537) | 2.46723643 |
| 119 | decidualization (GO:0046697) | 2.45886999 |
| 120 | regulation of collagen metabolic process (GO:0010712) | 2.45547654 |
| 121 | embryo implantation (GO:0007566) | 2.45449787 |
| 122 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.44072312 |
| 123 | kidney mesenchyme development (GO:0072074) | 2.43376509 |
| 124 | endocytic recycling (GO:0032456) | 2.43097769 |
| 125 | wound healing, spreading of cells (GO:0044319) | 2.41121849 |
| 126 | pattern specification involved in kidney development (GO:0061004) | 2.41001275 |
| 127 | formation of translation preinitiation complex (GO:0001731) | 2.40199649 |
| 128 | sequestering of metal ion (GO:0051238) | 2.39947823 |
| 129 | glycosphingolipid catabolic process (GO:0046479) | 2.39691455 |
| 130 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.39320000 |
| 131 | hypotonic response (GO:0006971) | 2.39043854 |
| 132 | NIK/NF-kappaB signaling (GO:0038061) | 2.37315142 |
| 133 | cellular response to unfolded protein (GO:0034620) | 2.36349424 |
| 134 | peptidyl-proline hydroxylation (GO:0019511) | 2.35853269 |
| 135 | macromolecular complex disassembly (GO:0032984) | 2.35822421 |
| 136 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241) | 2.35548945 |
| 137 | negative regulation of fatty acid transport (GO:2000192) | 2.34486572 |
| 138 | response to thyroid hormone (GO:0097066) | 2.32854100 |
| 139 | sequestering of actin monomers (GO:0042989) | 2.32705022 |
| 140 | response to progesterone (GO:0032570) | 2.32695071 |
| 141 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.32456654 |
| 142 | endocardial cushion development (GO:0003197) | 2.31334680 |
| 143 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.31077011 |
| 144 | cyclooxygenase pathway (GO:0019371) | 2.30254320 |
| 145 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.30109512 |
| 146 | DNA deamination (GO:0045006) | 2.29785198 |
| 147 | establishment of apical/basal cell polarity (GO:0035089) | 2.29527690 |
| 148 | bone trabecula formation (GO:0060346) | 2.29291903 |
| 149 | collagen metabolic process (GO:0032963) | 2.28072687 |
| 150 | cellular response to topologically incorrect protein (GO:0035967) | 2.27612502 |
| 151 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 2.27606581 |
| 152 | exocrine pancreas development (GO:0031017) | 2.27409667 |
| 153 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.26601600 |
| 154 | regulation of smooth muscle cell migration (GO:0014910) | 2.26486323 |
| 155 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 2.26458526 |
| 156 | adenosine receptor signaling pathway (GO:0001973) | 2.26165636 |
| 157 | cellular response to nutrient (GO:0031670) | 2.25644524 |
| 158 | platelet aggregation (GO:0070527) | 2.24789537 |
| 159 | regulation of SMAD protein import into nucleus (GO:0060390) | 2.24049186 |
| 160 | regulation of blood vessel endothelial cell migration (GO:0043535) | 2.23735244 |
| 161 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 2.23454905 |
| 162 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.22699935 |
| 163 | endosome to melanosome transport (GO:0035646) | 2.22521270 |
| 164 | endosome to pigment granule transport (GO:0043485) | 2.22521270 |
| 165 | phagocytosis, recognition (GO:0006910) | 2.22055512 |
| 166 | lymph vessel development (GO:0001945) | 2.22047437 |
| 167 | negative regulation of granulocyte differentiation (GO:0030853) | 2.21792482 |
| 168 | lymphocyte apoptotic process (GO:0070227) | 2.21635328 |
| 169 | regulation of apoptotic process involved in morphogenesis (GO:1902337) | 2.21313243 |
| 170 | anatomical structure regression (GO:0060033) | 2.21274292 |
| 171 | negative regulation of glycoprotein metabolic process (GO:1903019) | 2.20590841 |
| 172 | endothelial cell morphogenesis (GO:0001886) | 2.19042121 |
| 173 | cell adhesion mediated by integrin (GO:0033627) | 2.17600802 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.44701114 |
| 2 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.91852221 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.85039934 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.80007555 |
| 5 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.57841487 |
| 6 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.50691680 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.38838238 |
| 8 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.32897140 |
| 9 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.31080320 |
| 10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.17552759 |
| 11 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.12432304 |
| 12 | MYC_22102868_ChIP-Seq_BL_Human | 2.04039309 |
| 13 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.00592289 |
| 14 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.97621804 |
| 15 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.94281761 |
| 16 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.93008308 |
| 17 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.90860084 |
| 18 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.86497434 |
| 19 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.85101782 |
| 20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.78453329 |
| 21 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.70196903 |
| 22 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.66962931 |
| 23 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.66425659 |
| 24 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.66290954 |
| 25 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.65810650 |
| 26 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.65267001 |
| 27 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.61145120 |
| 28 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.58939474 |
| 29 | KDM2B_26808549_Chip-Seq_K562_Human | 1.54822504 |
| 30 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.54725259 |
| 31 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.54720753 |
| 32 | MAF_26560356_Chip-Seq_TH1_Human | 1.54513020 |
| 33 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.52686912 |
| 34 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.52122076 |
| 35 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.51243527 |
| 36 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.48594222 |
| 37 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.47692125 |
| 38 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.46861179 |
| 39 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.45943568 |
| 40 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.45604191 |
| 41 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.44903921 |
| 42 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.44848118 |
| 43 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.44188151 |
| 44 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.43122126 |
| 45 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.42603009 |
| 46 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.40013114 |
| 47 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.39706012 |
| 48 | UTX_26944678_Chip-Seq_JUKART_Human | 1.39198885 |
| 49 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.37963840 |
| 50 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.37654473 |
| 51 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.37212002 |
| 52 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36766542 |
| 53 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.35396670 |
| 54 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.33940967 |
| 55 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.33540857 |
| 56 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.33178348 |
| 57 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.33123220 |
| 58 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.32710409 |
| 59 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.32683709 |
| 60 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.32625454 |
| 61 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.32464963 |
| 62 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.32123807 |
| 63 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.31333567 |
| 64 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.31225160 |
| 65 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.31111927 |
| 66 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.31078444 |
| 67 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.30939294 |
| 68 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.30936605 |
| 69 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.30793275 |
| 70 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.29555287 |
| 71 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.26907754 |
| 72 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.26180384 |
| 73 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.25560684 |
| 74 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.25448167 |
| 75 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.25319194 |
| 76 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.24766039 |
| 77 | ATF3_27146783_Chip-Seq_COLON_Human | 1.22702800 |
| 78 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.21862864 |
| 79 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.21073052 |
| 80 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.20859989 |
| 81 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.20757356 |
| 82 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.20470812 |
| 83 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.20263589 |
| 84 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.19498770 |
| 85 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.19493786 |
| 86 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.18433567 |
| 87 | P68_20966046_ChIP-Seq_HELA_Human | 1.17451575 |
| 88 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.17239583 |
| 89 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.16916040 |
| 90 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.16728568 |
| 91 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.16391234 |
| 92 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.15892383 |
| 93 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.15764968 |
| 94 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.15284289 |
| 95 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14739104 |
| 96 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.13456865 |
| 97 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.13333355 |
| 98 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.13281749 |
| 99 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.12929359 |
| 100 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.12870156 |
| 101 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.12820518 |
| 102 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.12076494 |
| 103 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11681789 |
| 104 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.10530183 |
| 105 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.10176237 |
| 106 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.10030331 |
| 107 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.09655336 |
| 108 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.08557875 |
| 109 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.08340792 |
| 110 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.07834238 |
| 111 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.07139889 |
| 112 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.06520834 |
| 113 | SPI1_23127762_ChIP-Seq_K562_Human | 1.06371728 |
| 114 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.06334312 |
| 115 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.06084005 |
| 116 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.05779917 |
| 117 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.05694524 |
| 118 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.05638540 |
| 119 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.05573292 |
| 120 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.05425962 |
| 121 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.05018888 |
| 122 | MYB_26560356_Chip-Seq_TH2_Human | 1.05011222 |
| 123 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.04487533 |
| 124 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.04480392 |
| 125 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.04400228 |
| 126 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.03410413 |
| 127 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.03117248 |
| 128 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.02345583 |
| 129 | MAF_26560356_Chip-Seq_TH2_Human | 1.02227112 |
| 130 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.02200022 |
| 131 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 1.01677698 |
| 132 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.01377881 |
| 133 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.01186568 |
| 134 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.01159740 |
| 135 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.01060286 |
| 136 | SA1_22415368_ChIP-Seq_MEFs_Mouse | 1.00839066 |
| 137 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.00222329 |
| 138 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.99095711 |
| 139 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.99020722 |
| 140 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.98834348 |
| 141 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.98612335 |
| 142 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.98440864 |
| 143 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.98304616 |
| 144 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.97556404 |
| 145 | MYB_26560356_Chip-Seq_TH1_Human | 0.97324645 |
| 146 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.97116652 |
| 147 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.96933637 |
| 148 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.96754057 |
| 149 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96464218 |
| 150 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.95068556 |
| 151 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.95063201 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 4.68976727 |
| 2 | MP0010368_abnormal_lymphatic_system | 3.03693694 |
| 3 | MP0003705_abnormal_hypodermis_morpholog | 2.87916730 |
| 4 | MP0005503_abnormal_tendon_morphology | 2.73471001 |
| 5 | MP0005275_abnormal_skin_tensile | 2.72960370 |
| 6 | MP0003279_aneurysm | 2.72737779 |
| 7 | MP0006054_spinal_hemorrhage | 2.72491298 |
| 8 | MP0004272_abnormal_basement_membrane | 2.56961543 |
| 9 | MP0001879_abnormal_lymphatic_vessel | 2.52127463 |
| 10 | MP0002877_abnormal_melanocyte_morpholog | 2.45199663 |
| 11 | MP0001958_emphysema | 1.98008067 |
| 12 | MP0003566_abnormal_cell_adhesion | 1.95278331 |
| 13 | MP0000013_abnormal_adipose_tissue | 1.90980363 |
| 14 | MP0005023_abnormal_wound_healing | 1.86090623 |
| 15 | MP0003191_abnormal_cellular_cholesterol | 1.77012549 |
| 16 | MP0004858_abnormal_nervous_system | 1.75158233 |
| 17 | MP0010352_gastrointestinal_tract_polyps | 1.71781016 |
| 18 | MP0000685_abnormal_immune_system | 1.69204468 |
| 19 | MP0003172_abnormal_lysosome_physiology | 1.67083560 |
| 20 | MP0006082_CNS_inflammation | 1.60274205 |
| 21 | MP0005257_abnormal_intraocular_pressure | 1.59546194 |
| 22 | MP0002254_reproductive_system_inflammat | 1.52971347 |
| 23 | MP0009333_abnormal_splenocyte_physiolog | 1.49309073 |
| 24 | MP0005464_abnormal_platelet_physiology | 1.48846626 |
| 25 | MP0003724_increased_susceptibility_to | 1.44844620 |
| 26 | MP0001849_ear_inflammation | 1.42364430 |
| 27 | MP0000767_abnormal_smooth_muscle | 1.40129871 |
| 28 | MP0005595_abnormal_vascular_smooth | 1.36115890 |
| 29 | MP0004808_abnormal_hematopoietic_stem | 1.35802523 |
| 30 | MP0009278_abnormal_bone_marrow | 1.35357974 |
| 31 | MP0001243_abnormal_dermal_layer | 1.33562665 |
| 32 | MP0005508_abnormal_skeleton_morphology | 1.32581537 |
| 33 | MP0010030_abnormal_orbit_morphology | 1.32581537 |
| 34 | MP0000858_altered_metastatic_potential | 1.28967364 |
| 35 | MP0005623_abnormal_meninges_morphology | 1.28873671 |
| 36 | MP0003300_gastrointestinal_ulcer | 1.28691431 |
| 37 | MP0003283_abnormal_digestive_organ | 1.28163249 |
| 38 | MP0000678_abnormal_parathyroid_gland | 1.25976570 |
| 39 | MP0001835_abnormal_antigen_presentation | 1.24729963 |
| 40 | MP0009384_cardiac_valve_regurgitation | 1.24141832 |
| 41 | MP0009785_altered_susceptibility_to | 1.22964111 |
| 42 | MP0005220_abnormal_exocrine_pancreas | 1.21023116 |
| 43 | MP0008004_abnormal_stomach_pH | 1.20610915 |
| 44 | MP0002933_joint_inflammation | 1.19918224 |
| 45 | MP0003436_decreased_susceptibility_to | 1.19856064 |
| 46 | MP0002060_abnormal_skin_morphology | 1.18181034 |
| 47 | MP0000604_amyloidosis | 1.18109442 |
| 48 | MP0005451_abnormal_body_composition | 1.17671264 |
| 49 | MP0002295_abnormal_pulmonary_circulatio | 1.16722243 |
| 50 | MP0005076_abnormal_cell_differentiation | 1.13417003 |
| 51 | MP0005167_abnormal_blood-brain_barrier | 1.11356286 |
| 52 | MP0003075_altered_response_to | 1.09685802 |
| 53 | MP0001533_abnormal_skeleton_physiology | 1.09101849 |
| 54 | MP0005390_skeleton_phenotype | 1.08714498 |
| 55 | MP0001348_abnormal_lacrimal_gland | 1.06464647 |
| 56 | MP0000751_myopathy | 1.05235464 |
| 57 | MP0003091_abnormal_cell_migration | 1.04571819 |
| 58 | MP0002166_altered_tumor_susceptibility | 1.02802945 |
| 59 | MP0005164_abnormal_response_to | 1.01885849 |
| 60 | MP0001542_abnormal_bone_strength | 1.01524674 |
| 61 | MP0008007_abnormal_cellular_replicative | 0.99956600 |
| 62 | MP0005165_increased_susceptibility_to | 0.99442680 |
| 63 | MP0001944_abnormal_pancreas_morphology | 0.98866763 |
| 64 | MP0009379_abnormal_foot_pigmentation | 0.98610621 |
| 65 | MP0003448_altered_tumor_morphology | 0.98282766 |
| 66 | MP0003122_maternal_imprinting | 0.97511960 |
| 67 | MP0003385_abnormal_body_wall | 0.97417487 |
| 68 | MP0000733_abnormal_muscle_development | 0.96805558 |
| 69 | MP0002896_abnormal_bone_mineralization | 0.96670821 |
| 70 | MP0000681_abnormal_thyroid_gland | 0.95779327 |
| 71 | MP0003795_abnormal_bone_structure | 0.94240813 |
| 72 | MP0009764_decreased_sensitivity_to | 0.94116888 |
| 73 | MP0005671_abnormal_response_to | 0.94016664 |
| 74 | MP0003453_abnormal_keratinocyte_physiol | 0.93729216 |
| 75 | MP0003828_pulmonary_edema | 0.93526832 |
| 76 | MP0002998_abnormal_bone_remodeling | 0.92068030 |
| 77 | MP0001545_abnormal_hematopoietic_system | 0.91931311 |
| 78 | MP0005397_hematopoietic_system_phenotyp | 0.91931311 |
| 79 | MP0000003_abnormal_adipose_tissue | 0.91438100 |
| 80 | MP0005387_immune_system_phenotype | 0.90176248 |
| 81 | MP0001790_abnormal_immune_system | 0.90176248 |
| 82 | MP0000750_abnormal_muscle_regeneration | 0.89814257 |
| 83 | MP0002128_abnormal_blood_circulation | 0.89336480 |
| 84 | MP0000343_altered_response_to | 0.89265597 |
| 85 | MP0005058_abnormal_lysosome_morphology | 0.88984678 |
| 86 | MP0008260_abnormal_autophagy | 0.88878429 |
| 87 | MP0002148_abnormal_hypersensitivity_rea | 0.87552891 |
| 88 | MP0002405_respiratory_system_inflammati | 0.85773561 |
| 89 | MP0000249_abnormal_blood_vessel | 0.84990715 |
| 90 | MP0003303_peritoneal_inflammation | 0.84063927 |
| 91 | MP0005025_abnormal_response_to | 0.83760790 |
| 92 | MP0003763_abnormal_thymus_physiology | 0.83603876 |
| 93 | MP0005000_abnormal_immune_tolerance | 0.83399840 |
| 94 | MP0010155_abnormal_intestine_physiology | 0.83216296 |
| 95 | MP0002452_abnormal_antigen_presenting | 0.82468215 |
| 96 | MP0005084_abnormal_gallbladder_morpholo | 0.81238834 |
| 97 | MP0002113_abnormal_skeleton_development | 0.80579851 |
| 98 | MP0003941_abnormal_skin_development | 0.79399840 |
| 99 | MP0002006_tumorigenesis | 0.79255206 |
| 100 | MP0001614_abnormal_blood_vessel | 0.79125872 |
| 101 | MP0003942_abnormal_urinary_system | 0.78449809 |
| 102 | MP0002138_abnormal_hepatobiliary_system | 0.78006416 |
| 103 | MP0009840_abnormal_foam_cell | 0.77856457 |
| 104 | MP0003045_fibrosis | 0.77171473 |
| 105 | MP0002089_abnormal_postnatal_growth/wei | 0.76889525 |
| 106 | MP0009250_abnormal_appendicular_skeleto | 0.76870421 |
| 107 | MP0003123_paternal_imprinting | 0.76858692 |
| 108 | MP0002108_abnormal_muscle_morphology | 0.76062368 |
| 109 | MP0000163_abnormal_cartilage_morphology | 0.74607387 |
| 110 | MP0000465_gastrointestinal_hemorrhage | 0.74114112 |
| 111 | MP0002925_abnormal_cardiovascular_devel | 0.73926634 |
| 112 | MP0002723_abnormal_immune_serum | 0.73324195 |
| 113 | MP0004947_skin_inflammation | 0.73280650 |
| 114 | MP0002693_abnormal_pancreas_physiology | 0.73279273 |
| 115 | MP0004510_myositis | 0.72496687 |
| 116 | MP0001819_abnormal_immune_cell | 0.72288178 |
| 117 | MP0002420_abnormal_adaptive_immunity | 0.71603723 |
| 118 | MP0009643_abnormal_urine_homeostasis | 0.70931495 |
| 119 | MP0002419_abnormal_innate_immunity | 0.70721025 |
| 120 | MP0009053_abnormal_anal_canal | 0.69628625 |
| 121 | MP0001915_intracranial_hemorrhage | 0.69217035 |
| 122 | MP0002932_abnormal_joint_morphology | 0.68801146 |
| 123 | MP0002115_abnormal_skeleton_extremities | 0.68790418 |
| 124 | MP0001175_abnormal_lung_morphology | 0.67855941 |
| 125 | MP0004883_abnormal_blood_vessel | 0.67802600 |
| 126 | MP0001663_abnormal_digestive_system | 0.65513942 |
| 127 | MP0000759_abnormal_skeletal_muscle | 0.64422599 |
| 128 | MP0008469_abnormal_protein_level | 0.62691754 |
| 129 | MP0003329_amyloid_beta_deposits | 0.62320014 |
| 130 | MP0001845_abnormal_inflammatory_respons | 0.61556075 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 7.10425774 |
| 2 | Premature rupture of membranes (HP:0001788) | 5.75521983 |
| 3 | Abnormality of glycolipid metabolism (HP:0010969) | 4.08656186 |
| 4 | Abnormality of liposaccharide metabolism (HP:0010968) | 4.08656186 |
| 5 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 4.08656186 |
| 6 | Vertebral compression fractures (HP:0002953) | 3.94836725 |
| 7 | Peritonitis (HP:0002586) | 3.83757227 |
| 8 | Ankle contracture (HP:0006466) | 3.75951450 |
| 9 | Cervical subluxation (HP:0003308) | 3.63546230 |
| 10 | Aortic dissection (HP:0002647) | 3.55679588 |
| 11 | Broad metatarsal (HP:0001783) | 3.51950275 |
| 12 | Slender build (HP:0001533) | 3.47431637 |
| 13 | Soft skin (HP:0000977) | 3.43109193 |
| 14 | Cerebral aneurysm (HP:0004944) | 3.39965999 |
| 15 | Biconcave vertebral bodies (HP:0004586) | 3.33903070 |
| 16 | Shallow orbits (HP:0000586) | 3.15610240 |
| 17 | Atrophic scars (HP:0001075) | 3.14380411 |
| 18 | Nonimmune hydrops fetalis (HP:0001790) | 3.05401298 |
| 19 | Fragile skin (HP:0001030) | 2.98177473 |
| 20 | Abnormality of dentin (HP:0010299) | 2.97091390 |
| 21 | Aortic aneurysm (HP:0004942) | 2.92479421 |
| 22 | Bladder diverticulum (HP:0000015) | 2.89602434 |
| 23 | Blue sclerae (HP:0000592) | 2.79807115 |
| 24 | Dilatation of the ascending aorta (HP:0005111) | 2.79107981 |
| 25 | Increased variability in muscle fiber diameter (HP:0003557) | 2.76684527 |
| 26 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.72402147 |
| 27 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.72402147 |
| 28 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.72402147 |
| 29 | Achilles tendon contracture (HP:0001771) | 2.67145648 |
| 30 | Systemic lupus erythematosus (HP:0002725) | 2.63611220 |
| 31 | Arterial tortuosity (HP:0005116) | 2.60298291 |
| 32 | Spinal rigidity (HP:0003306) | 2.60259676 |
| 33 | Thrombocytosis (HP:0001894) | 2.59417984 |
| 34 | Thin bony cortex (HP:0002753) | 2.55400679 |
| 35 | Thoracolumbar scoliosis (HP:0002944) | 2.53036538 |
| 36 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.50727786 |
| 37 | Genu recurvatum (HP:0002816) | 2.44309930 |
| 38 | Beaking of vertebral bodies (HP:0004568) | 2.44298563 |
| 39 | Mitral valve prolapse (HP:0001634) | 2.39070927 |
| 40 | Abnormality of the nasal mucosa (HP:0000433) | 2.37866668 |
| 41 | Abnormality of the Achilles tendon (HP:0005109) | 2.36332578 |
| 42 | Slender long bone (HP:0003100) | 2.33807489 |
| 43 | Hematochezia (HP:0002573) | 2.33587207 |
| 44 | Axonal loss (HP:0003447) | 2.33584411 |
| 45 | Purpura (HP:0000979) | 2.32977890 |
| 46 | Aortic regurgitation (HP:0001659) | 2.32658561 |
| 47 | Broad face (HP:0000283) | 2.32457161 |
| 48 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.31868196 |
| 49 | Wormian bones (HP:0002645) | 2.31620256 |
| 50 | Nuclear cataract (HP:0100018) | 2.30314736 |
| 51 | Abnormality of the acetabulum (HP:0003170) | 2.29546980 |
| 52 | Long toe (HP:0010511) | 2.29087844 |
| 53 | Aneurysm (HP:0002617) | 2.24646847 |
| 54 | Disproportionate tall stature (HP:0001519) | 2.23743031 |
| 55 | Increased connective tissue (HP:0009025) | 2.22730215 |
| 56 | Polycythemia (HP:0001901) | 2.21506881 |
| 57 | J-shaped sella turcica (HP:0002680) | 2.19329209 |
| 58 | Joint stiffness (HP:0001387) | 2.18518715 |
| 59 | Abnormality of the peritoneum (HP:0002585) | 2.16955082 |
| 60 | Increased cerebral lipofuscin (HP:0011813) | 2.16192005 |
| 61 | Distal upper limb amyotrophy (HP:0007149) | 2.15156406 |
| 62 | Upper limb amyotrophy (HP:0009129) | 2.15156406 |
| 63 | Spontaneous hematomas (HP:0007420) | 2.14977101 |
| 64 | Radial bowing (HP:0002986) | 2.13554608 |
| 65 | Type 1 muscle fiber predominance (HP:0003803) | 2.10936585 |
| 66 | Camptodactyly of toe (HP:0001836) | 2.10678383 |
| 67 | Interstitial pulmonary disease (HP:0006530) | 2.06763037 |
| 68 | Follicular hyperkeratosis (HP:0007502) | 2.04328342 |
| 69 | Ectopia lentis (HP:0001083) | 2.04095932 |
| 70 | Petechiae (HP:0000967) | 2.02809188 |
| 71 | Osteopenia (HP:0000938) | 2.01246312 |
| 72 | Natal tooth (HP:0000695) | 2.00105490 |
| 73 | Loss of speech (HP:0002371) | 1.99464584 |
| 74 | Neonatal short-limb short stature (HP:0008921) | 1.98543797 |
| 75 | Bowing of the arm (HP:0006488) | 1.97929533 |
| 76 | Bowed forearm bones (HP:0003956) | 1.97929533 |
| 77 | Striae distensae (HP:0001065) | 1.97542544 |
| 78 | Dysostosis multiplex (HP:0000943) | 1.96808880 |
| 79 | Ovoid vertebral bodies (HP:0003300) | 1.96445294 |
| 80 | Hypoventilation (HP:0002791) | 1.95730711 |
| 81 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.94101465 |
| 82 | Abnormal delivery (HP:0001787) | 1.93676540 |
| 83 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.92009735 |
| 84 | Osteolytic defects of the hand bones (HP:0009699) | 1.92009735 |
| 85 | Hypoglycemic coma (HP:0001325) | 1.91367976 |
| 86 | Premature skin wrinkling (HP:0100678) | 1.91221623 |
| 87 | Bowel diverticulosis (HP:0005222) | 1.89395314 |
| 88 | Generalized amyotrophy (HP:0003700) | 1.88632327 |
| 89 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.87885876 |
| 90 | Abnormality of macrophages (HP:0004311) | 1.87548144 |
| 91 | Mitral regurgitation (HP:0001653) | 1.87380743 |
| 92 | Venous abnormality (HP:0002624) | 1.87178200 |
| 93 | Chondrocalcinosis (HP:0000934) | 1.86884780 |
| 94 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.86168802 |
| 95 | Mucopolysacchariduria (HP:0008155) | 1.86168802 |
| 96 | Reticulocytopenia (HP:0001896) | 1.85976415 |
| 97 | Distal lower limb muscle weakness (HP:0009053) | 1.84977708 |
| 98 | Platyspondyly (HP:0000926) | 1.84837072 |
| 99 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.82952165 |
| 100 | Flexion contracture of toe (HP:0005830) | 1.82134891 |
| 101 | Joint contractures involving the joints of the feet (HP:0100492) | 1.82134891 |
| 102 | Elbow flexion contracture (HP:0002987) | 1.80373437 |
| 103 | Hyperextensible skin (HP:0000974) | 1.79170876 |
| 104 | Flared iliac wings (HP:0002869) | 1.78285133 |
| 105 | Lymphangioma (HP:0100764) | 1.76418197 |
| 106 | Aortic valve stenosis (HP:0001650) | 1.76302535 |
| 107 | Emphysema (HP:0002097) | 1.75957991 |
| 108 | Wide anterior fontanel (HP:0000260) | 1.75905773 |
| 109 | Hyperacusis (HP:0010780) | 1.75865741 |
| 110 | Abnormality of complement system (HP:0005339) | 1.75863232 |
| 111 | Wrist flexion contracture (HP:0001239) | 1.74889043 |
| 112 | Myositis (HP:0100614) | 1.74537317 |
| 113 | Ulnar bowing (HP:0003031) | 1.74503903 |
| 114 | Selective tooth agenesis (HP:0001592) | 1.74099687 |
| 115 | Joint laxity (HP:0001388) | 1.73849298 |
| 116 | Trismus (HP:0000211) | 1.73703830 |
| 117 | Round ear (HP:0100830) | 1.73207463 |
| 118 | Mesomelia (HP:0003027) | 1.71834082 |
| 119 | Asymmetric septal hypertrophy (HP:0001670) | 1.71690869 |
| 120 | Venous insufficiency (HP:0005293) | 1.70899253 |
| 121 | Congenital glaucoma (HP:0001087) | 1.70733760 |
| 122 | Increased density of long bones (HP:0006392) | 1.70358082 |
| 123 | Short nail (HP:0001799) | 1.70305127 |
| 124 | Vascular tortuosity (HP:0004948) | 1.69704277 |
| 125 | Vacuolated lymphocytes (HP:0001922) | 1.69566061 |
| 126 | Myocardial infarction (HP:0001658) | 1.69537871 |
| 127 | Spondylolisthesis (HP:0003302) | 1.69195070 |
| 128 | Femoral bowing (HP:0002980) | 1.68381424 |
| 129 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.67054204 |
| 130 | Deviation of the hallux (HP:0010051) | 1.64940595 |
| 131 | Abnormality of Sharpey fibers (HP:0100685) | 1.63131295 |
| 132 | Hyperparathyroidism (HP:0000843) | 1.62944644 |
| 133 | Hallux valgus (HP:0001822) | 1.60571830 |
| 134 | Hypoglycemic seizures (HP:0002173) | 1.59850329 |
| 135 | Coxa vara (HP:0002812) | 1.59099922 |
| 136 | Hand muscle atrophy (HP:0009130) | 1.57929786 |
| 137 | Hypercortisolism (HP:0001578) | 1.57711106 |
| 138 | Abnormal hemoglobin (HP:0011902) | 1.57331767 |
| 139 | Mesangial abnormality (HP:0001966) | 1.56265866 |
| 140 | Short 4th metacarpal (HP:0010044) | 1.55928491 |
| 141 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.55928491 |
| 142 | Eczematoid dermatitis (HP:0000976) | 1.54358415 |
| 143 | Abnormality of skull ossification (HP:0002703) | 1.54300109 |
| 144 | Abnormality of T cell physiology (HP:0011840) | 1.53672135 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ERN1 | 3.80835194 |
| 2 | TRIB3 | 3.71260683 |
| 3 | KDR | 3.25041244 |
| 4 | NME2 | 3.20351493 |
| 5 | TIE1 | 2.80260142 |
| 6 | PKN2 | 2.71357796 |
| 7 | FLT3 | 2.57895069 |
| 8 | TGFBR2 | 2.16093600 |
| 9 | MAP3K10 | 2.11827462 |
| 10 | JAK3 | 2.02759126 |
| 11 | PIM2 | 1.99408314 |
| 12 | TGFBR1 | 1.95190864 |
| 13 | TAOK2 | 1.95085433 |
| 14 | RPS6KA4 | 1.85074068 |
| 15 | MAP4K1 | 1.81257033 |
| 16 | ZAP70 | 1.77972458 |
| 17 | PDGFRA | 1.77935978 |
| 18 | PASK | 1.73339900 |
| 19 | ABL2 | 1.72438915 |
| 20 | TBK1 | 1.67278965 |
| 21 | LRRK2 | 1.67060431 |
| 22 | MAPK15 | 1.65265172 |
| 23 | FGFR4 | 1.64641612 |
| 24 | PTK6 | 1.56339902 |
| 25 | PAK4 | 1.55991679 |
| 26 | PRPF4B | 1.55208846 |
| 27 | KIT | 1.55180783 |
| 28 | CDC42BPA | 1.52310587 |
| 29 | TESK1 | 1.51318855 |
| 30 | SCYL2 | 1.50953160 |
| 31 | TTN | 1.45746112 |
| 32 | SMG1 | 1.40250142 |
| 33 | MAP2K3 | 1.35110990 |
| 34 | ILK | 1.32333080 |
| 35 | TLK1 | 1.30055023 |
| 36 | GRK7 | 1.29983784 |
| 37 | MAP3K11 | 1.29677976 |
| 38 | ARAF | 1.29125916 |
| 39 | TYK2 | 1.26815737 |
| 40 | MAP3K6 | 1.23627423 |
| 41 | MAP3K3 | 1.23193028 |
| 42 | PTK2 | 1.18269575 |
| 43 | NTRK1 | 1.18129885 |
| 44 | EPHA3 | 1.17882269 |
| 45 | TAOK1 | 1.16762579 |
| 46 | EPHA2 | 1.16736333 |
| 47 | MYLK | 1.13986392 |
| 48 | PIK3CG | 1.12299886 |
| 49 | MAP3K13 | 1.11653226 |
| 50 | RIPK1 | 1.10580912 |
| 51 | PAK2 | 1.06626630 |
| 52 | ICK | 1.06412105 |
| 53 | RPS6KA2 | 1.05307203 |
| 54 | MARK2 | 1.03899325 |
| 55 | EPHB2 | 1.00999656 |
| 56 | RPS6KL1 | 0.99446640 |
| 57 | RPS6KC1 | 0.99446640 |
| 58 | SIK1 | 0.98741756 |
| 59 | NLK | 0.98139502 |
| 60 | BCKDK | 0.95304409 |
| 61 | DDR2 | 0.94066199 |
| 62 | EEF2K | 0.93454733 |
| 63 | IKBKB | 0.93434130 |
| 64 | PRKG2 | 0.88922256 |
| 65 | IKBKE | 0.88280669 |
| 66 | DYRK1B | 0.86758455 |
| 67 | PRKD2 | 0.85696699 |
| 68 | MATK | 0.85102399 |
| 69 | DYRK3 | 0.83327196 |
| 70 | MET | 0.83225201 |
| 71 | BTK | 0.82134644 |
| 72 | STK10 | 0.79014760 |
| 73 | RPS6KA6 | 0.78768513 |
| 74 | TESK2 | 0.77885900 |
| 75 | MAPKAPK3 | 0.77245007 |
| 76 | PDPK1 | 0.76868433 |
| 77 | CHUK | 0.76253350 |
| 78 | HIPK2 | 0.73944565 |
| 79 | DAPK3 | 0.73184362 |
| 80 | EPHB1 | 0.71393220 |
| 81 | MAPK7 | 0.70787027 |
| 82 | NEK9 | 0.69090101 |
| 83 | GRK6 | 0.66736140 |
| 84 | CSK | 0.65890447 |
| 85 | BUB1 | 0.65670163 |
| 86 | TEC | 0.64888722 |
| 87 | FER | 0.64507729 |
| 88 | MOS | 0.62897386 |
| 89 | IRAK3 | 0.61782507 |
| 90 | BMX | 0.60335359 |
| 91 | INSRR | 0.59197370 |
| 92 | IRAK4 | 0.59127208 |
| 93 | MAP3K8 | 0.56245873 |
| 94 | BRAF | 0.56160512 |
| 95 | MAP2K2 | 0.54722001 |
| 96 | ADRBK1 | 0.54354683 |
| 97 | JAK1 | 0.53884027 |
| 98 | IRAK1 | 0.53433168 |
| 99 | CDK8 | 0.51133345 |
| 100 | PRKCI | 0.50972862 |
| 101 | PTK2B | 0.50257174 |
| 102 | FES | 0.50149767 |
| 103 | LATS2 | 0.49867882 |
| 104 | PRKD3 | 0.49468968 |
| 105 | MAP3K1 | 0.49336119 |
| 106 | PIM1 | 0.48263053 |
| 107 | PDGFRB | 0.47432935 |
| 108 | STK38 | 0.46918990 |
| 109 | CDK7 | 0.46736980 |
| 110 | GSK3A | 0.46576875 |
| 111 | DMPK | 0.45694058 |
| 112 | MAPK4 | 0.45529674 |
| 113 | NEK2 | 0.45469594 |
| 114 | MTOR | 0.45222565 |
| 115 | TYRO3 | 0.44421828 |
| 116 | RPS6KB2 | 0.43819212 |
| 117 | RPS6KA5 | 0.43756906 |
| 118 | MAPKAPK2 | 0.43629680 |
| 119 | IRAK2 | 0.43167646 |
| 120 | ITK | 0.42258243 |
| 121 | FGFR3 | 0.41715675 |
| 122 | MAP3K14 | 0.41329898 |
| 123 | ROCK1 | 0.39955294 |
| 124 | LIMK1 | 0.39904222 |
| 125 | ADRBK2 | 0.39726293 |
| 126 | CSF1R | 0.39673856 |
| 127 | BLK | 0.38759653 |
| 128 | ROCK2 | 0.38757525 |
| 129 | GRK5 | 0.38420530 |
| 130 | LCK | 0.37715585 |
| 131 | MAP3K7 | 0.37119225 |
| 132 | PAK1 | 0.36654138 |
| 133 | WNK4 | 0.36542809 |
| 134 | PRKD1 | 0.35237059 |
| 135 | TXK | 0.33027477 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 3.44164992 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.12027507 |
| 3 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.72667523 |
| 4 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.95712417 |
| 5 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.95567954 |
| 6 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.88360061 |
| 7 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.86047675 |
| 8 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.80034929 |
| 9 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.71480797 |
| 10 | Focal adhesion_Homo sapiens_hsa04510 | 1.65734488 |
| 11 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.64903948 |
| 12 | Leishmaniasis_Homo sapiens_hsa05140 | 1.62147243 |
| 13 | Malaria_Homo sapiens_hsa05144 | 1.60812941 |
| 14 | Bladder cancer_Homo sapiens_hsa05219 | 1.57795696 |
| 15 | Prion diseases_Homo sapiens_hsa05020 | 1.54910888 |
| 16 | Legionellosis_Homo sapiens_hsa05134 | 1.50068285 |
| 17 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.47835716 |
| 18 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.45599442 |
| 19 | Shigellosis_Homo sapiens_hsa05131 | 1.45431608 |
| 20 | Other glycan degradation_Homo sapiens_hsa00511 | 1.45345502 |
| 21 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.39389715 |
| 22 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.39204631 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.38897415 |
| 24 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.36255963 |
| 25 | Proteasome_Homo sapiens_hsa03050 | 1.34252062 |
| 26 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.31982695 |
| 27 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.30994231 |
| 28 | Measles_Homo sapiens_hsa05162 | 1.27433867 |
| 29 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.26880268 |
| 30 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.26672259 |
| 31 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.23953055 |
| 32 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.23899374 |
| 33 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.23305879 |
| 34 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.23158320 |
| 35 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.21471973 |
| 36 | Lysosome_Homo sapiens_hsa04142 | 1.17289209 |
| 37 | Apoptosis_Homo sapiens_hsa04210 | 1.15936599 |
| 38 | DNA replication_Homo sapiens_hsa03030 | 1.15303599 |
| 39 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.14018800 |
| 40 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.13501048 |
| 41 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.13260780 |
| 42 | HTLV-I infection_Homo sapiens_hsa05166 | 1.12157022 |
| 43 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.10902460 |
| 44 | Amoebiasis_Homo sapiens_hsa05146 | 1.10797910 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.10162593 |
| 46 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.06804926 |
| 47 | Sulfur relay system_Homo sapiens_hsa04122 | 1.04729165 |
| 48 | Base excision repair_Homo sapiens_hsa03410 | 1.03777294 |
| 49 | Thyroid cancer_Homo sapiens_hsa05216 | 1.03247021 |
| 50 | Pertussis_Homo sapiens_hsa05133 | 1.00073956 |
| 51 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.99470847 |
| 52 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.98327135 |
| 53 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.98120474 |
| 54 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.97617254 |
| 55 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.97040178 |
| 56 | Viral myocarditis_Homo sapiens_hsa05416 | 0.96650284 |
| 57 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.96383965 |
| 58 | Adherens junction_Homo sapiens_hsa04520 | 0.96183709 |
| 59 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.95803084 |
| 60 | Galactose metabolism_Homo sapiens_hsa00052 | 0.95352076 |
| 61 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.94222840 |
| 62 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.93376892 |
| 63 | Hepatitis B_Homo sapiens_hsa05161 | 0.92762051 |
| 64 | Endocytosis_Homo sapiens_hsa04144 | 0.91555826 |
| 65 | Platelet activation_Homo sapiens_hsa04611 | 0.91148272 |
| 66 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.89989695 |
| 67 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.87072577 |
| 68 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.86926190 |
| 69 | Spliceosome_Homo sapiens_hsa03040 | 0.83661445 |
| 70 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.80799922 |
| 71 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.79850824 |
| 72 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.79042812 |
| 73 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.77896572 |
| 74 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.77463664 |
| 75 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.76211369 |
| 76 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.75558211 |
| 77 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.74694592 |
| 78 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.74483631 |
| 79 | Salmonella infection_Homo sapiens_hsa05132 | 0.74477753 |
| 80 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.74317737 |
| 81 | Influenza A_Homo sapiens_hsa05164 | 0.74313769 |
| 82 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.74152581 |
| 83 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.73041554 |
| 84 | Mismatch repair_Homo sapiens_hsa03430 | 0.72966601 |
| 85 | Asthma_Homo sapiens_hsa05310 | 0.71989456 |
| 86 | Pathways in cancer_Homo sapiens_hsa05200 | 0.69166550 |
| 87 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.69163933 |
| 88 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.68429364 |
| 89 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.68179189 |
| 90 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.67666496 |
| 91 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.67104088 |
| 92 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.66941199 |
| 93 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.66667912 |
| 94 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.66505913 |
| 95 | Melanoma_Homo sapiens_hsa05218 | 0.66235020 |
| 96 | Cell cycle_Homo sapiens_hsa04110 | 0.66191541 |
| 97 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.65945623 |
| 98 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.65791790 |
| 99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.65027306 |
| 100 | Allograft rejection_Homo sapiens_hsa05330 | 0.63485684 |
| 101 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.62842105 |
| 102 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.62190652 |
| 103 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.61070517 |
| 104 | Insulin resistance_Homo sapiens_hsa04931 | 0.60674664 |
| 105 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.59633184 |
| 106 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.59568602 |
| 107 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.58777083 |
| 108 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.58702030 |
| 109 | Tuberculosis_Homo sapiens_hsa05152 | 0.58645762 |
| 110 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.58229854 |
| 111 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.56624077 |
| 112 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.56185958 |
| 113 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.55945086 |
| 114 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.55859038 |
| 115 | Prostate cancer_Homo sapiens_hsa05215 | 0.55262201 |
| 116 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.54962274 |
| 117 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.53851586 |
| 118 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.53271005 |
| 119 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.53092641 |
| 120 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.52567469 |
| 121 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.50953818 |
| 122 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.50842416 |
| 123 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.50690077 |
| 124 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.50680702 |
| 125 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.49778530 |
| 126 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.49547521 |
| 127 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.49212647 |
| 128 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.48472120 |
| 129 | Phagosome_Homo sapiens_hsa04145 | 0.48446734 |
| 130 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.48112107 |
| 131 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.47727345 |
| 132 | RNA transport_Homo sapiens_hsa03013 | 0.46202801 |
| 133 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.45712535 |
| 134 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.44777615 |
| 135 | Hepatitis C_Homo sapiens_hsa05160 | 0.44512963 |

