EVA1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.88901699
2cilium movement (GO:0003341)8.35314352
3motile cilium assembly (GO:0044458)8.19904196
4epithelial cilium movement (GO:0003351)7.31188623
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.15874178
6axoneme assembly (GO:0035082)6.32978817
7ribosomal small subunit assembly (GO:0000028)4.81347611
8left/right pattern formation (GO:0060972)4.60727683
9one-carbon compound transport (GO:0019755)4.55457881
10regulation of cilium movement (GO:0003352)4.47295513
11negative regulation of humoral immune response (GO:0002921)4.44777036
12facial nerve structural organization (GO:0021612)4.21862007
13viral transcription (GO:0019083)4.17973112
14left/right axis specification (GO:0070986)4.04573836
15protein heterotetramerization (GO:0051290)3.98212264
16translational termination (GO:0006415)3.88785668
17primary alcohol catabolic process (GO:0034310)3.85342938
18negative regulation of complement activation (GO:0045916)3.83702505
19sphingoid metabolic process (GO:0046519)3.83050307
20ribosomal small subunit biogenesis (GO:0042274)3.79152145
21omega-hydroxylase P450 pathway (GO:0097267)3.77754799
22postsynaptic membrane organization (GO:0001941)3.73722097
23cilium organization (GO:0044782)3.66081854
24ventricular system development (GO:0021591)3.63950265
25superoxide anion generation (GO:0042554)3.60949009
26response to peptidoglycan (GO:0032494)3.56644914
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56102611
28cilium assembly (GO:0042384)3.54372322
29microtubule bundle formation (GO:0001578)3.52899381
30protein targeting to ER (GO:0045047)3.47241983
31cotranslational protein targeting to membrane (GO:0006613)3.46081467
32diterpenoid biosynthetic process (GO:0016102)3.45977224
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.45849707
34proteasome assembly (GO:0043248)3.42378304
35amino sugar catabolic process (GO:0046348)3.38288945
36negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.37432696
37iron ion import (GO:0097286)3.37295903
38intraciliary transport (GO:0042073)3.33679013
39protein localization to endoplasmic reticulum (GO:0070972)3.28543006
40glucosamine-containing compound catabolic process (GO:1901072)3.27428488
41response to folic acid (GO:0051593)3.27419876
42sympathetic nervous system development (GO:0048485)3.25783539
43negative regulation of protein activation cascade (GO:2000258)3.25431208
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24832271
45presynaptic membrane assembly (GO:0097105)3.24622647
46desmosome organization (GO:0002934)3.24362753
47regulation of integrin-mediated signaling pathway (GO:2001044)3.23590177
48lymphoid progenitor cell differentiation (GO:0002320)3.21704897
49maturation of SSU-rRNA (GO:0030490)3.19544582
50ethanol metabolic process (GO:0006067)3.17087587
51protein localization to cilium (GO:0061512)3.16075333
52phospholipid scrambling (GO:0017121)3.15974569
53cytochrome complex assembly (GO:0017004)3.13253854
54negative regulation of myeloid cell apoptotic process (GO:0033033)3.12840984
55regulation of interleukin-8 secretion (GO:2000482)3.11962274
56detection of bacterium (GO:0016045)3.11172302
57positive regulation of respiratory burst (GO:0060267)3.10858555
58positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.06207316
59detection of other organism (GO:0098543)3.03997660
60ribosomal large subunit biogenesis (GO:0042273)2.99227928
61cellular component assembly involved in morphogenesis (GO:0010927)2.97166353
62viral life cycle (GO:0019058)2.95995580
63mesonephros development (GO:0001823)2.95816833
64multicellular organismal water homeostasis (GO:0050891)2.94123817
65respiratory chain complex IV assembly (GO:0008535)2.93188657
66mature B cell differentiation (GO:0002335)2.91520457
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90939293
68glomerular epithelial cell development (GO:0072310)2.90256861
69negative regulation of protein localization to cell surface (GO:2000009)2.89177039
70cranial nerve structural organization (GO:0021604)2.88745529
71translational elongation (GO:0006414)2.88366938
72mesenchymal cell differentiation involved in kidney development (GO:0072161)2.87705020
73mesenchymal cell differentiation involved in renal system development (GO:2001012)2.87705020
74positive regulation of chemokine secretion (GO:0090197)2.85183779
75cilium morphogenesis (GO:0060271)2.85087199
76androgen biosynthetic process (GO:0006702)2.83010254
77negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.82105245
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81975001
79cellular protein complex disassembly (GO:0043624)2.81625808
80dendritic cell chemotaxis (GO:0002407)2.81239950
81photoreceptor cell maintenance (GO:0045494)2.77699016
82tolerance induction (GO:0002507)2.77122290
83establishment of protein localization to Golgi (GO:0072600)2.74883106
84glutathione derivative biosynthetic process (GO:1901687)2.74034840
85glutathione derivative metabolic process (GO:1901685)2.74034840
86mature B cell differentiation involved in immune response (GO:0002313)2.71020644
87retinol metabolic process (GO:0042572)2.69971170
88cell projection assembly (GO:0030031)2.69659632
89CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.68842781
90regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.68463690
91pyrimidine-containing compound transmembrane transport (GO:0072531)2.67463559
92G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.66793186
93fibroblast migration (GO:0010761)2.66754253
94cytoplasmic microtubule organization (GO:0031122)2.66081409
95positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.65230143
96negative regulation of immunoglobulin mediated immune response (GO:0002890)2.65163183
97negative regulation of B cell mediated immunity (GO:0002713)2.65163183
98phenol-containing compound catabolic process (GO:0019336)2.64902015
99vitamin transmembrane transport (GO:0035461)2.64177274
100positive regulation of cellular amide metabolic process (GO:0034250)2.63376351
101negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.63347288
102regulation of timing of cell differentiation (GO:0048505)2.62882610
103cranial nerve morphogenesis (GO:0021602)2.62279629
104definitive hemopoiesis (GO:0060216)2.61510449
105negative regulation of viral genome replication (GO:0045071)2.60856939
106establishment of skin barrier (GO:0061436)2.60479196
107response to muramyl dipeptide (GO:0032495)2.59884397
108angiogenesis involved in wound healing (GO:0060055)2.59506833
109negative regulation of execution phase of apoptosis (GO:1900118)2.58094716
110import into cell (GO:0098657)2.57841049
111positive regulation of steroid hormone secretion (GO:2000833)2.57155452
112nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.57033141
113centriole assembly (GO:0098534)2.56161410
114negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.56079689
115water homeostasis (GO:0030104)2.54985937
116regulation of development, heterochronic (GO:0040034)2.54181787
117bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53719642
118negative regulation of thymocyte apoptotic process (GO:0070244)2.52813301
119negative regulation of stress fiber assembly (GO:0051497)2.52224230
120interleukin-6-mediated signaling pathway (GO:0070102)2.51859391
121retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51169515
122neutrophil activation involved in immune response (GO:0002283)2.50906701
123regulation of interleukin-5 production (GO:0032674)2.50713689
124negative regulation of nitric oxide biosynthetic process (GO:0045019)2.50015676
125positive regulation of T cell mediated cytotoxicity (GO:0001916)2.48719114
126diol metabolic process (GO:0034311)2.48542935
127dendritic cell migration (GO:0036336)2.48500804
128negative regulation of T cell mediated immunity (GO:0002710)2.48081682
129positive regulation of antigen processing and presentation (GO:0002579)2.47654643
130terpenoid biosynthetic process (GO:0016114)2.47615078
131retinal metabolic process (GO:0042574)2.47118544
132renal absorption (GO:0070293)2.46527314
133presynaptic membrane organization (GO:0097090)2.46267919
134positive regulation of T cell migration (GO:2000406)2.45871164
135regulation of T-helper 1 cell differentiation (GO:0045625)2.45039610
136positive regulation of interleukin-1 beta secretion (GO:0050718)2.43552983
137cellular response to exogenous dsRNA (GO:0071360)2.43010879
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42816889
139regulation of interleukin-13 production (GO:0032656)2.42713124
140regulation of pigment cell differentiation (GO:0050932)2.41859409
141protein targeting to Golgi (GO:0000042)2.41614434
142regulation of chemokine secretion (GO:0090196)2.41202090
143growth hormone receptor signaling pathway (GO:0060396)2.39818400
144ethanol oxidation (GO:0006069)2.38052277
145negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.35683993
146negative regulation of T-helper cell differentiation (GO:0045623)2.35683993
147primary alcohol metabolic process (GO:0034308)2.35606711
148DNA deamination (GO:0045006)2.35366653
149lipoxygenase pathway (GO:0019372)2.35020213
150regulation of interleukin-6 biosynthetic process (GO:0045408)2.34896904
151thyroid hormone metabolic process (GO:0042403)2.34109295
152sperm capacitation (GO:0048240)2.33373333
153regulation of metalloenzyme activity (GO:0048552)2.33232321
154regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.32977360
155negative regulation of leukocyte chemotaxis (GO:0002689)2.32666097
156response to epinephrine (GO:0071871)2.32617021
157UDP-N-acetylglucosamine metabolic process (GO:0006047)2.31893166
158negative regulation of actin filament bundle assembly (GO:0032232)2.31885012
159positive regulation of lymphocyte migration (GO:2000403)2.31588038
160regulation of hypersensitivity (GO:0002883)2.31429179
161positive regulation of interleukin-8 secretion (GO:2000484)2.31110215
162regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.31043351
163myeloid dendritic cell activation (GO:0001773)2.30801959
164regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.30689880
165positive regulation of T-helper 1 type immune response (GO:0002827)2.29583657
166nucleoside diphosphate catabolic process (GO:0009134)2.28809554
167purinergic nucleotide receptor signaling pathway (GO:0035590)2.28735933
168regulation of antigen processing and presentation (GO:0002577)2.28410171
169regulation of germinal center formation (GO:0002634)2.28074790
170response to interferon-beta (GO:0035456)2.27507982
171regulation of cell proliferation involved in kidney development (GO:1901722)2.27208713
172thyroid hormone generation (GO:0006590)2.26865639
173regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.26535647
174protein complex disassembly (GO:0043241)2.26382851
175sphingomyelin metabolic process (GO:0006684)2.25766359
176negative regulation of transcription by competitive promoter binding (GO:0010944)2.25468153
177response to interferon-alpha (GO:0035455)2.25246679
178defense response to protozoan (GO:0042832)2.24896438
179regulation of corticosteroid hormone secretion (GO:2000846)2.24510189
180neutrophil activation (GO:0042119)2.24410778
181retinal cone cell development (GO:0046549)2.24064079
182regulation of apoptotic process involved in morphogenesis (GO:1902337)2.23479474
183regulation of T cell migration (GO:2000404)2.23251265
184doxorubicin metabolic process (GO:0044598)2.23181080
185multicellular organism reproduction (GO:0032504)2.23099623
186ubiquinone biosynthetic process (GO:0006744)2.23085243
187microtubule severing (GO:0051013)2.22105546
188lung epithelium development (GO:0060428)2.21245064
189negative regulation of T cell differentiation in thymus (GO:0033085)2.20410596
190peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.20156887
191response to nitrosative stress (GO:0051409)2.20016324
192protein localization to Golgi apparatus (GO:0034067)2.19994192
193regulation of microtubule-based movement (GO:0060632)2.17167686
194carnitine metabolic process (GO:0009437)2.15952612
195response to xenobiotic stimulus (GO:0009410)2.15905392
196protein polyglutamylation (GO:0018095)2.15025531
197thrombin receptor signaling pathway (GO:0070493)2.13963668
198axonemal dynein complex assembly (GO:0070286)10.3329716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.64259449
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.98478443
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.44923546
4EZH2_22144423_ChIP-Seq_EOC_Human3.35552007
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97085621
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.84614170
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.76528532
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.58424216
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.52926813
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48911828
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47970654
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.41760074
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.38720611
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37298227
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24727344
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.24468437
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23567329
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23387418
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16633536
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.13893078
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12405570
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.12104278
23SUZ12_27294783_Chip-Seq_NPCs_Mouse2.11957910
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.07854077
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.05941500
26NFE2_27457419_Chip-Seq_LIVER_Mouse2.04858280
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99431792
28IGF1R_20145208_ChIP-Seq_DFB_Human1.95665584
29DROSHA_22980978_ChIP-Seq_HELA_Human1.83808007
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79030447
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.78924406
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77245483
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.77191615
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.76816110
35CJUN_26792858_Chip-Seq_BT549_Human1.76334697
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75305576
37AHR_22903824_ChIP-Seq_MCF-7_Human1.74651839
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74158135
39IRF1_19129219_ChIP-ChIP_H3396_Human1.71110623
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.68304350
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68126040
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.65177428
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64038587
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63607384
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.63353113
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61456040
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60424265
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.59506269
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.58896825
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58773568
51GBX2_23144817_ChIP-Seq_PC3_Human1.57968195
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.57783738
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56226635
54P53_22387025_ChIP-Seq_ESCs_Mouse1.55798056
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.55220673
56SCL_19346495_ChIP-Seq_HPC-7_Human1.54792070
57NMYC_18555785_Chip-Seq_ESCs_Mouse1.54621982
58VDR_22108803_ChIP-Seq_LS180_Human1.54476765
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52787912
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52782003
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.52426303
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.51914721
63RNF2_27304074_Chip-Seq_NSC_Mouse1.49354654
64EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.49279295
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48896504
66TP63_23658742_ChIP-Seq_EP156T_Human1.48666439
67BCAT_22108803_ChIP-Seq_LS180_Human1.48345003
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47838712
69RUNX1_27457419_Chip-Seq_LIVER_Mouse1.47699165
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47409584
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44174068
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43919521
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.43638879
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43382333
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43315384
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41807985
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.40621167
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.40544095
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.38642534
80P300_18555785_Chip-Seq_ESCs_Mouse1.38186104
81SMAD4_21799915_ChIP-Seq_A2780_Human1.37221887
82SOX2_20726797_ChIP-Seq_SW620_Human1.35708713
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33884935
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33484158
85TP53_16413492_ChIP-PET_HCT116_Human1.33051952
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32591302
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32527928
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.32390204
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31987792
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29829593
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28889324
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28282664
93PU1_27457419_Chip-Seq_LIVER_Mouse1.28017120
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27984989
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.27850141
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.27758552
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27256396
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26646695
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26216389
100STAT3_23295773_ChIP-Seq_U87_Human1.25576945
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.25102065
102ZFX_18555785_Chip-Seq_ESCs_Mouse1.24888571
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24718386
104CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24658735
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24133677
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23961385
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.23867343
108STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23429093
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.23368673
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22388007
111AR_21572438_ChIP-Seq_LNCaP_Human1.21958199
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21482273
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.20718531
114ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20704266
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20617495
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18411086
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18154988
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17961258
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17536260
120STAT1_20625510_ChIP-Seq_HELA_Human1.17422647
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17275790
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.16811010
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.16416080
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16228764
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16228764
126POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16148682
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15478790
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15478790
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14373480
130KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13321145
131TAF15_26573619_Chip-Seq_HEK293_Human1.13010747
132GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11264215
133ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11239606
134SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11086265
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09985615
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08893572
137NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08834978
138EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08630061
139KLF5_25053715_ChIP-Seq_YYC3_Human1.07067669
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06859702
141JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06748882
142TP53_18474530_ChIP-ChIP_U2OS_Human1.06735914
143OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06031620
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05840555
145GATA4_25053715_ChIP-Seq_YYC3_Human1.05544163
146TP63_22573176_ChIP-Seq_HFKS_Human1.04816716
147CDX2_20551321_ChIP-Seq_CACO-2_Human1.04513148
148STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04379078
149LXR_22158963_ChIP-Seq_LIVER_Mouse1.03171098
150SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02916082
151TCF4_23295773_ChIP-Seq_U87_Human1.02616472
152STAT1_17558387_ChIP-Seq_HELA_Human1.02562928
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01340349
154IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00686636
155SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00424923
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00144961
157CDX2_22108803_ChIP-Seq_LS180_Human1.00136445
158TCF4_22108803_ChIP-Seq_LS180_Human0.99725784
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99032609
160RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98870444
161EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98870444
162P300_19829295_ChIP-Seq_ESCs_Human0.98705054
163CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97055095
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95626046
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.95193225
166SPI1_23547873_ChIP-Seq_NB4_Human0.94732452
167RUNX1_27514584_Chip-Seq_MCF-7_Human0.94542518
168CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93574263
169KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93277779
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.93049706
171GATA2_19941826_ChIP-Seq_K562_Human0.92472653
172FOXA2_19822575_ChIP-Seq_HepG2_Human0.92430682
173TBX20_22328084_ChIP-Seq_HEART_Mouse0.90533728
174TBX20_22080862_ChIP-Seq_HEART_Mouse0.90533728
175FOXA1_25552417_ChIP-Seq_VCAP_Human0.89706579
176AR_25329375_ChIP-Seq_VCAP_Human0.89407141
177GATA1_19941826_ChIP-Seq_K562_Human0.88588923
178PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85032618
179SMRT_27268052_Chip-Seq_Bcells_Human0.84192405
180AR_20517297_ChIP-Seq_VCAP_Human0.83593132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.09418663
2MP0009379_abnormal_foot_pigmentation4.58262417
3MP0009780_abnormal_chondrocyte_physiolo4.34978562
4MP0004381_abnormal_hair_follicle4.04414470
5MP0006292_abnormal_olfactory_placode3.52033936
6MP0005174_abnormal_tail_pigmentation3.44008012
7MP0005409_darkened_coat_color3.30898618
8MP0001188_hyperpigmentation3.10044680
9MP0003724_increased_susceptibility_to2.93067360
10MP0000015_abnormal_ear_pigmentation2.87895445
11MP0003950_abnormal_plasma_membrane2.81257870
12MP0010368_abnormal_lymphatic_system2.78457853
13MP0003045_fibrosis2.69828069
14MP0005670_abnormal_white_adipose2.69454702
15MP0004084_abnormal_cardiac_muscle2.68434566
16MP0004043_abnormal_pH_regulation2.58239189
17MP0000372_irregular_coat_pigmentation2.46553616
18MP0004215_abnormal_myocardial_fiber2.45130251
19MP0001835_abnormal_antigen_presentation2.43489210
20MP0009785_altered_susceptibility_to2.38424056
21MP0002148_abnormal_hypersensitivity_rea2.30032380
22MP0001984_abnormal_olfaction2.28013284
23MP0001986_abnormal_taste_sensitivity2.23169582
24MP0002653_abnormal_ependyma_morphology2.19150888
25MP0003941_abnormal_skin_development2.17934950
26MP0010678_abnormal_skin_adnexa2.14518449
27MP0001501_abnormal_sleep_pattern2.13715218
28MP0000566_synostosis2.07584462
29MP0005075_abnormal_melanosome_morpholog2.05693449
30MP0002168_other_aberrant_phenotype2.02125571
31MP0003566_abnormal_cell_adhesion1.90244324
32MP0002277_abnormal_respiratory_mucosa1.85747231
33MP0002837_dystrophic_cardiac_calcinosis1.83757515
34MP0008875_abnormal_xenobiotic_pharmacok1.83032481
35MP0002095_abnormal_skin_pigmentation1.82872625
36MP0003436_decreased_susceptibility_to1.82785549
37MP0004036_abnormal_muscle_relaxation1.82079657
38MP0002876_abnormal_thyroid_physiology1.79405918
39MP0006138_congestive_heart_failure1.77672759
40MP0002009_preneoplasia1.76040728
41MP0005671_abnormal_response_to1.74835101
42MP0005083_abnormal_biliary_tract1.74695886
43MP0008260_abnormal_autophagy1.73254853
44MP0005025_abnormal_response_to1.73043728
45MP0005000_abnormal_immune_tolerance1.65699054
46MP0000013_abnormal_adipose_tissue1.58033035
47MP0005165_increased_susceptibility_to1.57735545
48MP0004019_abnormal_vitamin_homeostasis1.57717224
49MP0003763_abnormal_thymus_physiology1.57106213
50MP0000427_abnormal_hair_cycle1.56039355
51MP0002419_abnormal_innate_immunity1.53583951
52MP0002638_abnormal_pupillary_reflex1.52552819
53MP0010234_abnormal_vibrissa_follicle1.50767042
54MP0004484_altered_response_of1.46154825
55MP0008775_abnormal_heart_ventricle1.45522412
56MP0003315_abnormal_perineum_morphology1.43789048
57MP0002177_abnormal_outer_ear1.42862217
58MP0000681_abnormal_thyroid_gland1.41987246
59MP0005551_abnormal_eye_electrophysiolog1.37837917
60MP0005023_abnormal_wound_healing1.36487299
61MP0005275_abnormal_skin_tensile1.33763248
62MP0002452_abnormal_antigen_presenting1.33720333
63MP0009764_decreased_sensitivity_to1.32326431
64MP0002723_abnormal_immune_serum1.31698399
65MP0002102_abnormal_ear_morphology1.31073500
66MP0001661_extended_life_span1.30919157
67MP0005171_absent_coat_pigmentation1.30457155
68MP0000230_abnormal_systemic_arterial1.29926212
69MP0005167_abnormal_blood-brain_barrier1.29269810
70MP0001346_abnormal_lacrimal_gland1.26365790
71MP0003011_delayed_dark_adaptation1.25112484
72MP0008995_early_reproductive_senescence1.25105072
73MP0001765_abnormal_ion_homeostasis1.23315192
74MP0001819_abnormal_immune_cell1.21908217
75MP0002132_abnormal_respiratory_system1.21647490
76MP0001800_abnormal_humoral_immune1.21117038
77MP0000685_abnormal_immune_system1.20682670
78MP0005084_abnormal_gallbladder_morpholo1.20413953
79MP0006054_spinal_hemorrhage1.19962881
80MP0002420_abnormal_adaptive_immunity1.19961097
81MP0005464_abnormal_platelet_physiology1.19881766
82MP0002332_abnormal_exercise_endurance1.18792279
83MP0001790_abnormal_immune_system1.18136119
84MP0005387_immune_system_phenotype1.18136119
85MP0000858_altered_metastatic_potential1.16276138
86MP0004085_abnormal_heartbeat1.15823246
87MP0001853_heart_inflammation1.15371075
88MP0002249_abnormal_larynx_morphology1.14393510
89MP0003453_abnormal_keratinocyte_physiol1.12112489
90MP0005395_other_phenotype1.11724642
91MP0003786_premature_aging1.10889506
92MP0001851_eye_inflammation1.10563844
93MP0005164_abnormal_response_to1.10275562
94MP0001756_abnormal_urination1.09117339
95MP0003656_abnormal_erythrocyte_physiolo1.08873380
96MP0005646_abnormal_pituitary_gland1.06886299
97MP0009333_abnormal_splenocyte_physiolog1.06550115
98MP0002938_white_spotting1.05685492
99MP0005330_cardiomyopathy1.05203497
100MP0002006_tumorigenesis1.05098636
101MP0003879_abnormal_hair_cell1.04297811
102MP0002295_abnormal_pulmonary_circulatio1.03277539
103MP0000049_abnormal_middle_ear1.03186034
104MP0001664_abnormal_digestion1.01815328
105MP0000467_abnormal_esophagus_morphology1.01718996
106MP0004130_abnormal_muscle_cell1.01507206
107MP0000678_abnormal_parathyroid_gland1.00969643
108MP0005623_abnormal_meninges_morphology1.00869950
109MP0002163_abnormal_gland_morphology1.00371821
110MP0006036_abnormal_mitochondrial_physio1.00190782
111MP0005503_abnormal_tendon_morphology0.99669222
112MP0003938_abnormal_ear_development0.99576347
113MP0002254_reproductive_system_inflammat0.99362614
114MP0009643_abnormal_urine_homeostasis0.99358746
115MP0004782_abnormal_surfactant_physiolog0.97930625
116MP0002098_abnormal_vibrissa_morphology0.97384276
117MP0005253_abnormal_eye_physiology0.97237525
118MP0000249_abnormal_blood_vessel0.96669653
119MP0001919_abnormal_reproductive_system0.96150606
120MP0010352_gastrointestinal_tract_polyps0.95971509
121MP0003943_abnormal_hepatobiliary_system0.95848346
122MP0000490_abnormal_crypts_of0.94486264
123MP0004272_abnormal_basement_membrane0.92245544
124MP0005595_abnormal_vascular_smooth0.92113373
125MP0002751_abnormal_autonomic_nervous0.91712148
126MP0010030_abnormal_orbit_morphology0.91528199
127MP0004133_heterotaxia0.90673763
128MP0002998_abnormal_bone_remodeling0.88608961
129MP0000613_abnormal_salivary_gland0.88309824
130MP0010155_abnormal_intestine_physiology0.87799770
131MP0001502_abnormal_circadian_rhythm0.87450194
132MP0001533_abnormal_skeleton_physiology0.85824359
133MP0000569_abnormal_digit_pigmentation0.85246793
134MP0003880_abnormal_central_pattern0.84271845
135MP0002972_abnormal_cardiac_muscle0.83514092
136MP0002108_abnormal_muscle_morphology0.83043203
137MP0003718_maternal_effect0.82813740
138MP0002166_altered_tumor_susceptibility0.82563232
139MP0005620_abnormal_muscle_contractility0.81688981
140MP0004947_skin_inflammation0.81385694
141MP0002971_abnormal_brown_adipose0.81069287
142MP0005636_abnormal_mineral_homeostasis0.81062357
143MP0002136_abnormal_kidney_physiology0.80647483
144MP0010771_integument_phenotype0.80639398
145MP0000383_abnormal_hair_follicle0.79623740
146MP0001845_abnormal_inflammatory_respons0.78241557
147MP0002405_respiratory_system_inflammati0.77919098
148MP0003137_abnormal_impulse_conducting0.77256890
149MP0010386_abnormal_urinary_bladder0.77131842
150MP0006082_CNS_inflammation0.77024182
151MP0003828_pulmonary_edema0.76818702
152MP0000465_gastrointestinal_hemorrhage0.76274050
153MP0008872_abnormal_physiological_respon0.76242566
154MP0005220_abnormal_exocrine_pancreas0.75922657
155MP0000716_abnormal_immune_system0.75476081
156MP0005390_skeleton_phenotype0.74675728
157MP0000343_altered_response_to0.74239774
158MP0002282_abnormal_trachea_morphology0.73848857
159MP0000026_abnormal_inner_ear0.73293730
160MP0003300_gastrointestinal_ulcer0.72082666
161MP0001542_abnormal_bone_strength0.71820427
162MP0008961_abnormal_basal_metabolism0.71333145
163MP0002060_abnormal_skin_morphology0.71306063
164MP0002398_abnormal_bone_marrow0.70003369
165MP0002160_abnormal_reproductive_system0.69948097
166MP0002127_abnormal_cardiovascular_syste0.69374955
167MP0001186_pigmentation_phenotype0.69134268
168MP0005257_abnormal_intraocular_pressure0.69094207
169MP0000579_abnormal_nail_morphology0.69035601
170MP0001545_abnormal_hematopoietic_system0.68937309
171MP0005397_hematopoietic_system_phenotyp0.68937309
172MP0002796_impaired_skin_barrier0.68859923
173MP0005375_adipose_tissue_phenotype0.68853017
174MP0001879_abnormal_lymphatic_vessel0.68614610
175MP0005266_abnormal_metabolism0.66929778
176MP0010329_abnormal_lipoprotein_level0.66723401
177MP0008469_abnormal_protein_level0.66121032
178MP0008004_abnormal_stomach_pH0.65792543
179MP0002933_joint_inflammation0.65051803
180MP0005408_hypopigmentation0.64327474
181MP0002075_abnormal_coat/hair_pigmentati0.64205603
182MP0006276_abnormal_autonomic_nervous0.64050765
183MP0005379_endocrine/exocrine_gland_phen0.63864406
184MP0003303_peritoneal_inflammation0.63422856
185MP0009250_abnormal_appendicular_skeleto0.63082614

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.06800591
2Abnormal ciliary motility (HP:0012262)8.48720395
3Abnormal respiratory epithelium morphology (HP:0012253)8.40917427
4Abnormal respiratory motile cilium morphology (HP:0005938)8.40917427
5Abnormal respiratory motile cilium physiology (HP:0012261)8.36631997
6Rhinitis (HP:0012384)7.67857370
7Chronic bronchitis (HP:0004469)6.04336195
8Bronchiectasis (HP:0002110)5.64542588
9Nasal polyposis (HP:0100582)4.93002355
10Abnormality of the nasal mucosa (HP:0000433)4.51368215
11Type I transferrin isoform profile (HP:0003642)4.36151079
12Reduced antithrombin III activity (HP:0001976)4.06925844
13Male infertility (HP:0003251)3.71479756
14Pancreatic fibrosis (HP:0100732)3.42322608
15Occipital encephalocele (HP:0002085)3.36352910
16Bronchitis (HP:0012387)3.36169191
17Chronic sinusitis (HP:0011109)3.31498393
18Infertility (HP:0000789)3.27117561
19Reticulocytopenia (HP:0001896)3.26289615
20Abnormality of the axillary hair (HP:0100134)3.25737245
21Abnormality of secondary sexual hair (HP:0009888)3.25737245
22Nonprogressive disorder (HP:0003680)3.24279288
23Abnormality of cells of the erythroid lineage (HP:0012130)3.23538001
24Pancreatic cysts (HP:0001737)3.11275574
25Abnormal number of erythroid precursors (HP:0012131)3.11051233
26Cystic liver disease (HP:0006706)3.06490675
27Absent rod-and cone-mediated responses on ERG (HP:0007688)3.06282275
28Chronic hepatic failure (HP:0100626)3.03464779
29Abnormality of midbrain morphology (HP:0002418)2.94095267
30Molar tooth sign on MRI (HP:0002419)2.94095267
31Chronic otitis media (HP:0000389)2.91729816
32Hyperactive renin-angiotensin system (HP:0000841)2.91695483
33Chronic obstructive pulmonary disease (HP:0006510)2.89329073
34Obstructive lung disease (HP:0006536)2.89329073
35Hypothermia (HP:0002045)2.89269063
36Right ventricular cardiomyopathy (HP:0011663)2.85515039
37Retrobulbar optic neuritis (HP:0100654)2.80393032
38Optic neuritis (HP:0100653)2.80393032
39Mediastinal lymphadenopathy (HP:0100721)2.76067653
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.72505699
41Abnormal protein N-linked glycosylation (HP:0012347)2.72505699
42Abnormal protein glycosylation (HP:0012346)2.72505699
43Abnormal glycosylation (HP:0012345)2.72505699
44Eczematoid dermatitis (HP:0000976)2.71195748
45Recurrent abscess formation (HP:0002722)2.70098067
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69055341
47Recurrent sinusitis (HP:0011108)2.67209520
48Nephronophthisis (HP:0000090)2.64564390
49Myositis (HP:0100614)2.61789834
50Dry hair (HP:0011359)2.58832606
51Orchitis (HP:0100796)2.57394418
52Meningitis (HP:0001287)2.54813733
53Parakeratosis (HP:0001036)2.54697083
54Abnormality of the renal medulla (HP:0100957)2.52175615
55Elevated erythrocyte sedimentation rate (HP:0003565)2.51331857
56Stomatitis (HP:0010280)2.48354902
57Conical tooth (HP:0000698)2.45918452
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45017455
59Recurrent otitis media (HP:0000403)2.39418968
60Aplastic anemia (HP:0001915)2.37915065
61Chromsome breakage (HP:0040012)2.36527276
62Bell-shaped thorax (HP:0001591)2.34797659
63Abnormality of the prostate (HP:0008775)2.34740661
64Atelectasis (HP:0100750)2.34555685
65Glucose intolerance (HP:0000833)2.34525901
66Anhidrosis (HP:0000970)2.34453626
67Congenital, generalized hypertrichosis (HP:0004540)2.33213095
68Patchy hypopigmentation of hair (HP:0011365)2.32596952
69Thyroid-stimulating hormone excess (HP:0002925)2.32255917
70Joint hemorrhage (HP:0005261)2.32026758
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30384491
723-Methylglutaconic aciduria (HP:0003535)2.30315876
73Pallor (HP:0000980)2.29300107
74Central scotoma (HP:0000603)2.28586585
75Congenital hepatic fibrosis (HP:0002612)2.28312236
76Decreased circulating renin level (HP:0003351)2.25873113
77Abnormal drinking behavior (HP:0030082)2.24060672
78Polydipsia (HP:0001959)2.24060672
79Abnormal sex determination (HP:0012244)2.23279373
80Sex reversal (HP:0012245)2.23279373
81Tubulointerstitial nephritis (HP:0001970)2.22261872
82Macrocytic anemia (HP:0001972)2.20177629
83Recurrent bacterial skin infections (HP:0005406)2.19960491
84Recurrent cutaneous fungal infections (HP:0011370)2.19849859
85Chronic mucocutaneous candidiasis (HP:0002728)2.19849859
86White forelock (HP:0002211)2.19243998
87Abnormal hemoglobin (HP:0011902)2.17172987
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15771104
89Type 2 muscle fiber atrophy (HP:0003554)2.12637978
90Optic nerve hypoplasia (HP:0000609)2.11297460
91Clubbing of toes (HP:0100760)2.10841341
92Decreased central vision (HP:0007663)2.09361970
93Abnormality of the renal cortex (HP:0011035)2.07775954
94Vacuolated lymphocytes (HP:0001922)2.05725787
95Attenuation of retinal blood vessels (HP:0007843)2.05498936
96Septo-optic dysplasia (HP:0100842)2.05381988
97Amelogenesis imperfecta (HP:0000705)2.04265258
98Absent/shortened dynein arms (HP:0200106)2.04215125
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.04215125
100Menorrhagia (HP:0000132)2.04112044
101Cheilitis (HP:0100825)2.04034911
102Postaxial foot polydactyly (HP:0001830)2.02669432
103Abnormality of the preputium (HP:0100587)2.02659937
104Hemoptysis (HP:0002105)2.02079066
105Prostate neoplasm (HP:0100787)2.01729633
106Prolonged bleeding time (HP:0003010)1.98489920
107Renal Fanconi syndrome (HP:0001994)1.98363994
108Tubular atrophy (HP:0000092)1.97988361
109Gastrointestinal infarctions (HP:0005244)1.97435236
110Increased IgM level (HP:0003496)1.94282845
111Muscle fiber atrophy (HP:0100295)1.94084279
112Hyperkalemia (HP:0002153)1.92644163
113Aplasia/Hypoplasia of the fovea (HP:0008060)1.92244215
114Hypoplasia of the fovea (HP:0007750)1.92244215
115Thoracic kyphosis (HP:0002942)1.91019869
116Abnormality of macular pigmentation (HP:0008002)1.90744470
117Abnormal rod and cone electroretinograms (HP:0008323)1.90042204
118Abnormality of renin-angiotensin system (HP:0000847)1.89867218
119Syncope (HP:0001279)1.89548897
120Hypoplastic labia majora (HP:0000059)1.88904287
121Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87717538
122Aortic aneurysm (HP:0004942)1.87541816
123Petechiae (HP:0000967)1.86853622
124Absent frontal sinuses (HP:0002688)1.86358133
125Congenital sensorineural hearing impairment (HP:0008527)1.86262288
126Meckel diverticulum (HP:0002245)1.85671240
127Abnormality of macrophages (HP:0004311)1.85191454
128Popliteal pterygium (HP:0009756)1.84572026
129Vasculitis (HP:0002633)1.84254359
130Lip pit (HP:0100267)1.83284681
131Abnormality of dental color (HP:0011073)1.83230459
132Renal salt wasting (HP:0000127)1.82635709
133Medial flaring of the eyebrow (HP:0010747)1.82508984
134Triphalangeal thumb (HP:0001199)1.81983631
135Albinism (HP:0001022)1.80704663
136True hermaphroditism (HP:0010459)1.80348935
137Epistaxis (HP:0000421)1.79603648
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.78359486
139Absent septum pellucidum (HP:0001331)1.77321144
140Dyschromatopsia (HP:0007641)1.77174323
141Recurrent skin infections (HP:0001581)1.77023077
142Optic disc pallor (HP:0000543)1.75846934
143Abnormality of magnesium homeostasis (HP:0004921)1.75012363
144Portal hypertension (HP:0001409)1.74769091
145Stage 5 chronic kidney disease (HP:0003774)1.74314909
146Gangrene (HP:0100758)1.73929478
147Male pseudohermaphroditism (HP:0000037)1.73141843
148Furrowed tongue (HP:0000221)1.73006510
149Aplasia/hypoplasia of the uterus (HP:0008684)1.72542611
150Abnormality of the septum pellucidum (HP:0007375)1.72014426
151Agammaglobulinemia (HP:0004432)1.71075570
152Abnormality of the ileum (HP:0001549)1.70678711
153Pulmonary infiltrates (HP:0002113)1.70163189
154Microcytic anemia (HP:0001935)1.70091571
155Hypokalemic alkalosis (HP:0001949)1.69889736
156Abnormality of the labia majora (HP:0012881)1.69547912
157Purpura (HP:0000979)1.68813422
158Natal tooth (HP:0000695)1.68488396
159Metaphyseal dysplasia (HP:0100255)1.64884010
160Polyuria (HP:0000103)1.64807929
161Hyperaldosteronism (HP:0000859)1.61635812
162Clumsiness (HP:0002312)1.61111417
163Vascular calcification (HP:0004934)1.60739001
164Congenital primary aphakia (HP:0007707)1.60229068
165Absent speech (HP:0001344)1.60080179
166Atrial fibrillation (HP:0005110)1.55144113
167Short nail (HP:0001799)1.53177315
168Abnormality of the hepatic vasculature (HP:0006707)1.52796972
169Facial diplegia (HP:0001349)1.52049315
170Recurrent bronchitis (HP:0002837)1.51804375
171Abnormal glucose tolerance (HP:0001952)1.50108296
172Abnormality of the distal phalanges of the toes (HP:0010182)1.48951968
173Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.48044018
174Increased mean platelet volume (HP:0011877)1.47333643
175Tubulointerstitial abnormality (HP:0001969)1.47144294
176Gait imbalance (HP:0002141)1.46997540
177Alopecia of scalp (HP:0002293)1.46713832
178Asplenia (HP:0001746)1.45888855
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.43209169
180Abnormality of renal excretion (HP:0011036)1.42744605
181Ventricular fibrillation (HP:0001663)1.41457809
182Cardiovascular calcification (HP:0011915)1.40695637
183Hyperlipoproteinemia (HP:0010980)1.40682010
184Difficulty walking (HP:0002355)1.39424746
185Interstitial pulmonary disease (HP:0006530)1.37727380
186Congenital stationary night blindness (HP:0007642)1.37649113
187Muscle fiber splitting (HP:0003555)1.37210486
188Sclerocornea (HP:0000647)1.36985475
189Primary atrial arrhythmia (HP:0001692)1.36678218
190Nephropathy (HP:0000112)1.35843542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.48786452
2CASK4.32071634
3NME23.94358794
4MUSK3.55796079
5MAPKAPK33.21742722
6MKNK23.19475430
7EPHA23.13569166
8IRAK33.04506143
9TNIK3.00898673
10NLK2.62041892
11IRAK42.52721766
12PDK22.31339597
13EIF2AK32.19432575
14TXK2.19408346
15MAP3K142.12848854
16TLK12.07655223
17PTK2B2.04012670
18MKNK11.96206674
19MET1.92397310
20MAP2K71.91372049
21STK161.89659567
22MAP4K21.87294665
23STK38L1.82799872
24LATS11.80873339
25EIF2AK21.75608853
26SRPK11.71791085
27PIM21.71392649
28FER1.69951038
29IRAK11.67595887
30TEC1.66386596
31MAP3K21.63600896
32YES11.61088714
33INSRR1.58431425
34CLK11.55955807
35IKBKB1.55428673
36PRKD21.51348980
37LMTK21.45716747
38EPHB11.45484483
39STK391.43183837
40MAP3K71.41623526
41IKBKE1.38454050
42DMPK1.38209435
43IRAK21.35494726
44KIT1.24217151
45RIPK41.22179634
46BMPR1B1.18908888
47NME11.18232083
48BLK1.17988919
49ADRBK21.15307325
50CDK191.15149957
51EPHA31.14757255
52GRK71.12897319
53EEF2K1.12784852
54MAP3K121.11085637
55BMPR21.10398529
56TRPM71.08871913
57ACVR1B1.08704399
58EIF2AK11.05867467
59BTK1.02774627
60PRPF4B0.98796646
61MST1R0.98109007
62TGFBR20.96950755
63CDK30.96900402
64PRKD30.95811345
65STK30.94618870
66FES0.92107148
67GRK10.91518939
68TIE10.91147509
69PINK10.89828205
70ADRBK10.87712702
71ROCK10.87226597
72MST40.86633448
73BMX0.86441307
74RIPK10.85943370
75PIK3CG0.85043652
76PRKAA20.84269482
77GRK60.84190197
78VRK10.83028619
79TBK10.82351692
80TAOK20.80952077
81PBK0.78928102
82ZAK0.78605688
83JAK10.78289595
84ERBB30.78211527
85MAPK130.77412493
86JAK30.76987660
87HIPK20.76592826
88KDR0.74895591
89TNK20.74496873
90PRKD10.74206058
91PRKG20.74003806
92LYN0.73145898
93STK240.72495760
94ILK0.69681033
95PIM10.68525118
96SYK0.67078265
97CAMKK20.66874860
98PAK30.64895432
99MAPKAPK50.61338456
100MARK20.61271602
101MAPK110.60077578
102STK380.59617962
103OXSR10.59501792
104PDPK10.59439149
105NTRK30.59196650
106MAPK150.56022809
107PLK40.55493843
108ITK0.55188033
109CHUK0.54971226
110MAP3K130.51917318
111MAP3K30.51764566
112NEK60.49941574
113MAP3K110.48454316
114TTN0.47242659
115MAP3K10.47038970
116MATK0.46483995
117HCK0.46321893
118RPS6KA50.46072111
119TYK20.44873748
120RPS6KA40.44871455
121CSK0.44783903
122LCK0.44720039
123RAF10.44677770
124CAMK2G0.43686026
125EPHB20.42138634
126CAMK10.41831292
127PTK20.41755422
128BRSK20.40657025
129CDC42BPA0.40337314
130STK100.39311900
131TGFBR10.38922426
132PDK10.38892848
133PRKCD0.38494588
134DYRK30.37790317
135MAP4K10.37382986
136RPS6KA60.37359979
137MAP2K60.37084950
138RPS6KL10.37023910
139RPS6KC10.37023910
140MELK0.36958933
141NEK90.36305685
142GRK50.36186133
143TAOK30.36021126
144MAP2K20.35393807
145PRKCE0.35336470
146SGK20.34753618
147ABL20.34708124
148GSK3A0.34649664
149MAPKAPK20.34222001
150PKN10.33637056
151PHKG10.33568833
152PHKG20.33568833
153MAPK40.33074207
154PRKCQ0.32492676
155DYRK20.32323829
156MYLK0.32054136
157ZAP700.31819847
158CAMK2A0.31397873
159ERBB20.30617091
160CDK80.28253193
161ABL10.26879377

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.08890532
2beta-Alanine metabolism_Homo sapiens_hsa004102.90892321
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.68375515
4Phenylalanine metabolism_Homo sapiens_hsa003602.62695458
5Graft-versus-host disease_Homo sapiens_hsa053322.61365143
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.56555522
7Circadian rhythm_Homo sapiens_hsa047102.32075397
8Chemical carcinogenesis_Homo sapiens_hsa052042.20944486
9Nitrogen metabolism_Homo sapiens_hsa009102.20007455
10ABC transporters_Homo sapiens_hsa020102.14683766
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11556829
12Sphingolipid metabolism_Homo sapiens_hsa006002.05112452
13ECM-receptor interaction_Homo sapiens_hsa045122.03317883
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03191224
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01201027
16Tyrosine metabolism_Homo sapiens_hsa003501.98451980
17Allograft rejection_Homo sapiens_hsa053301.97070001
18Homologous recombination_Homo sapiens_hsa034401.90720754
19Arachidonic acid metabolism_Homo sapiens_hsa005901.90334719
20Protein export_Homo sapiens_hsa030601.82211350
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.78593045
22Fanconi anemia pathway_Homo sapiens_hsa034601.72920526
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.71140042
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.67902416
25Other glycan degradation_Homo sapiens_hsa005111.63912217
26Hematopoietic cell lineage_Homo sapiens_hsa046401.62294349
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61712666
28Glutathione metabolism_Homo sapiens_hsa004801.61094259
29Salivary secretion_Homo sapiens_hsa049701.53884327
30Measles_Homo sapiens_hsa051621.49332815
31Asthma_Homo sapiens_hsa053101.47500355
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.45241411
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45006966
34Platelet activation_Homo sapiens_hsa046111.43604666
35Autoimmune thyroid disease_Homo sapiens_hsa053201.43127363
36Leishmaniasis_Homo sapiens_hsa051401.42829116
37Glycerolipid metabolism_Homo sapiens_hsa005611.41925514
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41897500
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41717354
40Malaria_Homo sapiens_hsa051441.36946771
41Primary immunodeficiency_Homo sapiens_hsa053401.36783318
42Tryptophan metabolism_Homo sapiens_hsa003801.32931247
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31266302
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29984721
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.29886947
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26423502
47RNA polymerase_Homo sapiens_hsa030201.25642211
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23955877
49Dilated cardiomyopathy_Homo sapiens_hsa054141.23853267
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22342542
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21950960
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19645511
53Renin secretion_Homo sapiens_hsa049241.19585878
54Serotonergic synapse_Homo sapiens_hsa047261.15569966
55Rheumatoid arthritis_Homo sapiens_hsa053231.15032517
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13904283
57Pertussis_Homo sapiens_hsa051331.12899470
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.11527214
59Fatty acid degradation_Homo sapiens_hsa000711.11302071
60Pancreatic secretion_Homo sapiens_hsa049721.10717530
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10616817
62DNA replication_Homo sapiens_hsa030301.10241679
63Ether lipid metabolism_Homo sapiens_hsa005651.10001947
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09818266
65Phototransduction_Homo sapiens_hsa047441.07647500
66Basal transcription factors_Homo sapiens_hsa030221.07152283
67Sulfur metabolism_Homo sapiens_hsa009201.05250630
68Herpes simplex infection_Homo sapiens_hsa051681.04336374
69Tight junction_Homo sapiens_hsa045301.03132413
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02968684
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02146299
72Butanoate metabolism_Homo sapiens_hsa006501.01835234
73Calcium signaling pathway_Homo sapiens_hsa040201.01816577
74Olfactory transduction_Homo sapiens_hsa047401.00957544
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99428795
76Pyrimidine metabolism_Homo sapiens_hsa002400.98050224
77Linoleic acid metabolism_Homo sapiens_hsa005910.96843211
78Regulation of autophagy_Homo sapiens_hsa041400.94463679
79TNF signaling pathway_Homo sapiens_hsa046680.94054176
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.93353179
81Circadian entrainment_Homo sapiens_hsa047130.92614071
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90243619
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89382209
84Focal adhesion_Homo sapiens_hsa045100.86686316
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85677427
86Type I diabetes mellitus_Homo sapiens_hsa049400.85127165
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84746220
88Complement and coagulation cascades_Homo sapiens_hsa046100.84153142
89Oxidative phosphorylation_Homo sapiens_hsa001900.84049384
90p53 signaling pathway_Homo sapiens_hsa041150.82880464
91Influenza A_Homo sapiens_hsa051640.81812980
92Osteoclast differentiation_Homo sapiens_hsa043800.81340702
93cAMP signaling pathway_Homo sapiens_hsa040240.80692607
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.79322112
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78064111
96Purine metabolism_Homo sapiens_hsa002300.77199736
97Tuberculosis_Homo sapiens_hsa051520.77121475
98Gastric acid secretion_Homo sapiens_hsa049710.76443912
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.76429280
100African trypanosomiasis_Homo sapiens_hsa051430.76386479
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74661075
102Morphine addiction_Homo sapiens_hsa050320.73738247
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73297454
104Dorso-ventral axis formation_Homo sapiens_hsa043200.72377109
105Legionellosis_Homo sapiens_hsa051340.71661611
106PPAR signaling pathway_Homo sapiens_hsa033200.70614409
107Base excision repair_Homo sapiens_hsa034100.70084350
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68796075
109Fatty acid biosynthesis_Homo sapiens_hsa000610.68594018
110Thyroid cancer_Homo sapiens_hsa052160.67477813
111Mineral absorption_Homo sapiens_hsa049780.66086700
112Apoptosis_Homo sapiens_hsa042100.64394212
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64072618
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63549471
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63478482
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62911293
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62478928
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62276135
119Retinol metabolism_Homo sapiens_hsa008300.61400159
120Histidine metabolism_Homo sapiens_hsa003400.61259669
121Non-homologous end-joining_Homo sapiens_hsa034500.61050818
122Insulin secretion_Homo sapiens_hsa049110.60357576
123Nucleotide excision repair_Homo sapiens_hsa034200.58044244
124Acute myeloid leukemia_Homo sapiens_hsa052210.56938127
125Glutamatergic synapse_Homo sapiens_hsa047240.56240983
126Vitamin digestion and absorption_Homo sapiens_hsa049770.55866610
127Salmonella infection_Homo sapiens_hsa051320.55775588
128Antigen processing and presentation_Homo sapiens_hsa046120.55752718
129Toxoplasmosis_Homo sapiens_hsa051450.54904439
130Hepatitis C_Homo sapiens_hsa051600.54800822
131Ovarian steroidogenesis_Homo sapiens_hsa049130.54696791
132Oxytocin signaling pathway_Homo sapiens_hsa049210.52902775
133Hepatitis B_Homo sapiens_hsa051610.52225585
134Arginine and proline metabolism_Homo sapiens_hsa003300.52169683
135Basal cell carcinoma_Homo sapiens_hsa052170.51111681
136Choline metabolism in cancer_Homo sapiens_hsa052310.50170002
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48309101
138Proteasome_Homo sapiens_hsa030500.46533865
139Chemokine signaling pathway_Homo sapiens_hsa040620.46466778
140Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46027394
141N-Glycan biosynthesis_Homo sapiens_hsa005100.45557286
142Spliceosome_Homo sapiens_hsa030400.45073225
143Staphylococcus aureus infection_Homo sapiens_hsa051500.45047613
144Phagosome_Homo sapiens_hsa041450.44452369
145Peroxisome_Homo sapiens_hsa041460.44375631
146Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44087950
147Insulin resistance_Homo sapiens_hsa049310.41624209
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41533299
149Amphetamine addiction_Homo sapiens_hsa050310.40378888
150Lysine degradation_Homo sapiens_hsa003100.40353329
151Adherens junction_Homo sapiens_hsa045200.39991326
152Bile secretion_Homo sapiens_hsa049760.39356115
153Folate biosynthesis_Homo sapiens_hsa007900.37547193
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37365050
155Huntingtons disease_Homo sapiens_hsa050160.36460661
156Wnt signaling pathway_Homo sapiens_hsa043100.36228362
157Phospholipase D signaling pathway_Homo sapiens_hsa040720.35168840
158Alzheimers disease_Homo sapiens_hsa050100.34784941
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34672276
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34129633
161Taste transduction_Homo sapiens_hsa047420.34115847
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.33809240
163T cell receptor signaling pathway_Homo sapiens_hsa046600.33463431
164Sulfur relay system_Homo sapiens_hsa041220.33379717
165Small cell lung cancer_Homo sapiens_hsa052220.33007965
166Parkinsons disease_Homo sapiens_hsa050120.32941421
167Amoebiasis_Homo sapiens_hsa051460.31617336
168Cocaine addiction_Homo sapiens_hsa050300.31283750

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