EVC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions in bone formation and skeletal development. Mutations in this gene, as well as in a neighboring gene that lies in a head-to-head configuration, cause Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia that is also known as chondroectodermal dysplasia. Mutations in this gene also cause acrofacial dysostosis Weyers type, also referred to as Curry-Hall syndrome, a disease that combines limb and facial abnormalities. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.08345228
2positive regulation of uterine smooth muscle contraction (GO:0070474)4.94869282
3chondrocyte proliferation (GO:0035988)4.84625818
4negative regulation of osteoblast proliferation (GO:0033689)4.62434808
5paraxial mesoderm development (GO:0048339)4.61342878
6regulation of meiosis I (GO:0060631)4.58796661
7collagen fibril organization (GO:0030199)4.50753497
8positive regulation of male gonad development (GO:2000020)4.39408151
9regulation of uterine smooth muscle contraction (GO:0070472)4.22446597
10outer ear morphogenesis (GO:0042473)4.19549299
11germ cell migration (GO:0008354)4.16053258
12tachykinin receptor signaling pathway (GO:0007217)4.14023755
13substrate-dependent cell migration (GO:0006929)4.04885170
14bone trabecula formation (GO:0060346)4.04711448
15metanephric mesenchyme development (GO:0072075)4.01640190
16axon extension involved in axon guidance (GO:0048846)4.00472310
17neuron projection extension involved in neuron projection guidance (GO:1902284)4.00472310
18plasma membrane repair (GO:0001778)3.86654084
19regulation of hippo signaling (GO:0035330)3.86439356
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.86300878
21hippo signaling (GO:0035329)3.84968019
22polarized epithelial cell differentiation (GO:0030859)3.81596509
23kidney mesenchyme development (GO:0072074)3.76361371
24extracellular matrix assembly (GO:0085029)3.73742677
25positive regulation of action potential (GO:0045760)3.63240268
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.60413403
27endodermal cell differentiation (GO:0035987)3.60054679
28sequestering of extracellular ligand from receptor (GO:0035581)3.59938205
29blood vessel maturation (GO:0001955)3.58947047
30barbed-end actin filament capping (GO:0051016)3.47919469
31G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.46690487
32extracellular fibril organization (GO:0043206)3.45747369
33negative regulation of chondrocyte differentiation (GO:0032331)3.44833265
34mesenchymal-epithelial cell signaling (GO:0060638)3.43865458
35vascular endothelial growth factor signaling pathway (GO:0038084)3.42124942
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.33451087
37epithelial cell-cell adhesion (GO:0090136)3.32844400
38regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.30242770
39regulation of osteoblast proliferation (GO:0033688)3.29247292
40adherens junction assembly (GO:0034333)3.27572822
41artery development (GO:0060840)3.24941163
42basement membrane organization (GO:0071711)3.23338628
43urinary tract smooth muscle contraction (GO:0014848)3.22969360
44oocyte development (GO:0048599)3.20384479
45microtubule severing (GO:0051013)3.16653028
46mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.14329414
47insulin-like growth factor receptor signaling pathway (GO:0048009)3.13214015
48regulation of male gonad development (GO:2000018)3.09788791
49glomerular basement membrane development (GO:0032836)3.08881496
50craniofacial suture morphogenesis (GO:0097094)3.07251622
51fibril organization (GO:0097435)3.06399599
52endocardial cushion development (GO:0003197)3.06341437
53virion attachment to host cell (GO:0019062)3.06230888
54adhesion of symbiont to host cell (GO:0044650)3.06230888
55chondrocyte development (GO:0002063)3.05609589
56heterochromatin organization (GO:0070828)3.04747556
57cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.03641728
58notochord development (GO:0030903)3.02804277
59regulation of heart morphogenesis (GO:2000826)2.99563556
60establishment of apical/basal cell polarity (GO:0035089)2.98844718
61regulation of tight junction assembly (GO:2000810)2.95920957
62collagen metabolic process (GO:0032963)2.95206599
63cell-substrate junction assembly (GO:0007044)2.94793204
64regulation of posttranscriptional gene silencing (GO:0060147)2.93664208
65regulation of gene silencing by miRNA (GO:0060964)2.93664208
66regulation of gene silencing by RNA (GO:0060966)2.93664208
67negative regulation of cartilage development (GO:0061037)2.92404970
68aggressive behavior (GO:0002118)2.89406458
69endothelial cell morphogenesis (GO:0001886)2.87944395
70mesenchyme development (GO:0060485)2.86983207
71collagen catabolic process (GO:0030574)2.85431910
72substrate adhesion-dependent cell spreading (GO:0034446)2.84853966
73dermatan sulfate biosynthetic process (GO:0030208)2.83590149
74anterior/posterior axis specification, embryo (GO:0008595)2.82633481
75lymphangiogenesis (GO:0001946)2.82431817
76protein localization to cell surface (GO:0034394)2.82265926
77regulation of SMAD protein import into nucleus (GO:0060390)2.81905617
78endothelium development (GO:0003158)2.81675801
79negative regulation of meiosis (GO:0045835)2.81546449
80smooth muscle tissue development (GO:0048745)2.81534141
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81014494
82Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.78972065
83multicellular organismal macromolecule metabolic process (GO:0044259)2.78515770
84glomerular visceral epithelial cell development (GO:0072015)2.77790354
85retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77625865
86negative regulation of catenin import into nucleus (GO:0035414)2.77111480
87extracellular matrix organization (GO:0030198)2.77071512
88extracellular structure organization (GO:0043062)2.77025372
89positive regulation of SMAD protein import into nucleus (GO:0060391)2.76118770
90lung-associated mesenchyme development (GO:0060484)2.75951198
91non-canonical Wnt signaling pathway (GO:0035567)2.75859501
92focal adhesion assembly (GO:0048041)2.74627941
93cell-substrate adherens junction assembly (GO:0007045)2.74627941
94gastrulation with mouth forming second (GO:0001702)2.74524556
95drinking behavior (GO:0042756)2.74294271
96venous blood vessel morphogenesis (GO:0048845)2.74248517
97regulation of translational fidelity (GO:0006450)2.73922756
98organ induction (GO:0001759)2.73894580
99embryonic skeletal joint morphogenesis (GO:0060272)2.71655393
100negative regulation of DNA repair (GO:0045738)2.70922088
101skin morphogenesis (GO:0043589)2.70798961
102regulation of chondrocyte differentiation (GO:0032330)2.70645713
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70595063
104keratan sulfate catabolic process (GO:0042340)2.70342672
105stress fiber assembly (GO:0043149)2.68399437
106positive regulation of cartilage development (GO:0061036)2.68096744
107positive regulation of vascular permeability (GO:0043117)2.68003953
108regulation of establishment of planar polarity (GO:0090175)2.67880942
109hyaluronan catabolic process (GO:0030214)2.66937787
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.66928035
111metanephric nephron tubule development (GO:0072234)2.66377344
112metanephric tubule development (GO:0072170)2.66377344
113positive regulation of blood vessel endothelial cell migration (GO:0043536)2.65605879
114heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.64254179
115DNA unwinding involved in DNA replication (GO:0006268)2.63734205
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63682016
117peptidyl-proline hydroxylation (GO:0019511)2.63578802
118negative regulation of fatty acid transport (GO:2000192)2.63529501
119regulation of smooth muscle cell migration (GO:0014910)2.62970546
120cellular response to vitamin (GO:0071295)2.62823587
121atrioventricular valve morphogenesis (GO:0003181)2.62637877
122negative regulation of embryonic development (GO:0045992)2.62295375
123cochlea morphogenesis (GO:0090103)2.61879734
124negative regulation of BMP signaling pathway (GO:0030514)2.61799467
125embryonic camera-type eye development (GO:0031076)2.61323740
126positive regulation of endothelial cell apoptotic process (GO:2000353)2.61155014
127hemidesmosome assembly (GO:0031581)2.60891136
128multicellular organismal metabolic process (GO:0044236)2.60572353
129regulation of catenin import into nucleus (GO:0035412)2.60506611
130apoptotic cell clearance (GO:0043277)2.58925613
131multicellular organismal catabolic process (GO:0044243)2.58859824
132cell migration involved in sprouting angiogenesis (GO:0002042)2.58790516
133extracellular matrix disassembly (GO:0022617)2.58611208
134wound healing, spreading of epidermal cells (GO:0035313)2.58325193
135middle ear morphogenesis (GO:0042474)2.58072104
136protein hydroxylation (GO:0018126)2.56938064
137positive regulation of mesenchymal cell proliferation (GO:0002053)2.55650392
138collecting duct development (GO:0072044)2.54926882
139embryonic cranial skeleton morphogenesis (GO:0048701)2.54161762
140anatomical structure regression (GO:0060033)2.53216591
141regulation of gastrulation (GO:0010470)2.52365616
142body morphogenesis (GO:0010171)2.50676829
143cell migration involved in heart development (GO:0060973)2.50084727
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.49523355
145cell proliferation involved in metanephros development (GO:0072203)2.48189515
146cell adhesion mediated by integrin (GO:0033627)2.47518119
147dermatan sulfate metabolic process (GO:0030205)2.46227216
148proximal/distal pattern formation (GO:0009954)2.45154256
149metanephric nephron epithelium development (GO:0072243)2.44232542
150regulation of mitotic spindle organization (GO:0060236)2.42905221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.59258807
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.86132680
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.61483741
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.96976429
5CLOCK_20551151_ChIP-Seq_293T_Human2.80552119
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71800728
7WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.61130709
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59812970
9E2F7_22180533_ChIP-Seq_HELA_Human2.46220205
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.44008815
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.43509229
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.31126981
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.27204011
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22053918
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19339600
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.19175870
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.14974712
18* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.03834104
19GATA2_21666600_ChIP-Seq_HMVEC_Human2.00680290
20AR_21909140_ChIP-Seq_LNCAP_Human1.97287651
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.96579378
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95939230
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.95150845
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.94956031
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91963940
26* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.91486915
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91293024
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91293024
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91293024
30TP53_18474530_ChIP-ChIP_U2OS_Human1.89838069
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83223050
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80806073
33NFIB_24661679_ChIP-Seq_LUNG_Mouse1.79594696
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.79391856
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75765953
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.74550034
37* MYC_18555785_ChIP-Seq_MESCs_Mouse1.74496306
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72954945
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.64947436
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.62173102
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.61302252
42* BRD4_25478319_ChIP-Seq_HGPS_Human1.60803466
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60529689
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60129843
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60033263
46JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58402380
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57366756
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57366756
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57126055
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56710849
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53739210
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.52512804
53ATF3_27146783_Chip-Seq_COLON_Human1.52387787
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49113160
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.48968319
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48521922
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.47849318
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45586555
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44435910
60TP53_16413492_ChIP-PET_HCT116_Human1.42998255
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.40586736
62PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.40386292
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.40289293
64GATA1_22025678_ChIP-Seq_K562_Human1.39143177
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36815987
66ZNF263_19887448_ChIP-Seq_K562_Human1.35737683
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34509589
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33862748
69RACK7_27058665_Chip-Seq_MCF-7_Human1.32430083
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.32109585
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31957276
72TP53_22127205_ChIP-Seq_IMR90_Human1.31586222
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31082514
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29655529
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29313788
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28738787
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.26986387
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25206253
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24384820
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.23896207
81SA1_22415368_ChIP-Seq_MEFs_Mouse1.23476384
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23237895
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22777677
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22367364
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21915126
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21556586
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21413235
88* TP53_23651856_ChIP-Seq_MEFs_Mouse1.20605989
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19759792
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19316932
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19172772
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17628410
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16953122
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16571475
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16571475
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16278256
97CJUN_26792858_Chip-Seq_BT549_Human1.15006014
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14993673
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13087769
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12883582
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.12533445
102* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12084623
103* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11930420
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11233687
105TP63_23658742_ChIP-Seq_EP156T_Human1.11163747
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10319916
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10034973
108KDM2B_26808549_Chip-Seq_K562_Human1.09357486
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08698798
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06767060
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06197862
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05726499
113POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05401172
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04998614
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04847408
116EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04203572
117RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04203572
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04068237
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03871667
120PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.03775628
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02902381
122LXR_22292898_ChIP-Seq_THP-1_Human1.02162309
123KDM2B_26808549_Chip-Seq_DND41_Human1.01551138
124EED_16625203_ChIP-ChIP_MESCs_Mouse1.00852508
125* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00448730
126SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00352486
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99822150
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99414119
129GATA1_26923725_Chip-Seq_HPCs_Mouse0.98023844
130TBX20_22328084_ChIP-Seq_HEART_Mouse0.97913979
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.97913979
132SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97278371
133* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96302614
134GBX2_23144817_ChIP-Seq_PC3_Human0.95930358
135* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95809388
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92665531
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.91642105
138* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91005862
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90956457
140AHR_22903824_ChIP-Seq_MCF-7_Human0.90414573
141VDR_24787735_ChIP-Seq_THP-1_Human0.89514407
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.89102828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.78129679
2MP0003705_abnormal_hypodermis_morpholog4.28421591
3MP0005275_abnormal_skin_tensile3.76330223
4MP0005503_abnormal_tendon_morphology3.74331604
5MP0010030_abnormal_orbit_morphology3.11545073
6MP0005623_abnormal_meninges_morphology3.03899809
7MP0004272_abnormal_basement_membrane2.67961387
8MP0001958_emphysema2.60405064
9MP0003279_aneurysm2.53595576
10MP0003950_abnormal_plasma_membrane2.41627012
11MP0003283_abnormal_digestive_organ2.17673435
12MP0010352_gastrointestinal_tract_polyps1.96731923
13MP0000733_abnormal_muscle_development1.86355741
14MP0000537_abnormal_urethra_morphology1.85076740
15MP0001542_abnormal_bone_strength1.77856366
16MP0005508_abnormal_skeleton_morphology1.76980611
17MP0003385_abnormal_body_wall1.74471329
18MP0002254_reproductive_system_inflammat1.72779496
19MP0003566_abnormal_cell_adhesion1.72658931
20MP0009384_cardiac_valve_regurgitation1.71850282
21MP0009250_abnormal_appendicular_skeleto1.71707375
22MP0000534_abnormal_ureter_morphology1.71018672
23MP0003942_abnormal_urinary_system1.69454747
24MP0005257_abnormal_intraocular_pressure1.69243480
25MP0002108_abnormal_muscle_morphology1.67613233
26MP0009053_abnormal_anal_canal1.59980131
27MP0006054_spinal_hemorrhage1.57264172
28MP0000751_myopathy1.52558516
29MP0003123_paternal_imprinting1.49802939
30MP0002249_abnormal_larynx_morphology1.49131605
31MP0000428_abnormal_craniofacial_morphol1.47887362
32MP0002932_abnormal_joint_morphology1.46276859
33MP0004233_abnormal_muscle_weight1.43629719
34MP0000049_abnormal_middle_ear1.40541907
35MP0001299_abnormal_eye_distance/1.37821480
36MP0002282_abnormal_trachea_morphology1.36371285
37MP0002060_abnormal_skin_morphology1.36358081
38MP0000750_abnormal_muscle_regeneration1.36190423
39MP0001849_ear_inflammation1.36054768
40MP0005023_abnormal_wound_healing1.32895219
41MP0002896_abnormal_bone_mineralization1.32777895
42MP0003115_abnormal_respiratory_system1.32700832
43MP0003937_abnormal_limbs/digits/tail_de1.32615097
44MP0003941_abnormal_skin_development1.29943557
45MP0005595_abnormal_vascular_smooth1.28659239
46MP0003091_abnormal_cell_migration1.27788732
47MP0003755_abnormal_palate_morphology1.22242944
48MP0004197_abnormal_fetal_growth/weight/1.20185919
49MP0002234_abnormal_pharynx_morphology1.19904486
50MP0002089_abnormal_postnatal_growth/wei1.19454623
51MP0003935_abnormal_craniofacial_develop1.14446298
52MP0002933_joint_inflammation1.13586740
53MP0001243_abnormal_dermal_layer1.13278905
54MP0000432_abnormal_head_morphology1.11727526
55MP0000762_abnormal_tongue_morphology1.10887094
56MP0000163_abnormal_cartilage_morphology1.09233673
57MP0002084_abnormal_developmental_patter1.06446426
58MP0003828_pulmonary_edema1.05779996
59MP0005076_abnormal_cell_differentiation1.05374535
60MP0002115_abnormal_skeleton_extremities1.05322961
61MP0001879_abnormal_lymphatic_vessel1.04476039
62MP0002116_abnormal_craniofacial_bone1.03854011
63MP0002111_abnormal_tail_morphology1.03134607
64MP0002877_abnormal_melanocyte_morpholog1.02952667
65MP0004036_abnormal_muscle_relaxation1.00902374
66MP0010234_abnormal_vibrissa_follicle1.00851536
67MP0002114_abnormal_axial_skeleton1.00348721
68MP0002233_abnormal_nose_morphology1.00333424
69MP0002697_abnormal_eye_size0.99070243
70MP0009780_abnormal_chondrocyte_physiolo0.98941875
71MP0001293_anophthalmia0.98801039
72MP0004858_abnormal_nervous_system0.98133428
73MP0000749_muscle_degeneration0.97982231
74MP0002085_abnormal_embryonic_tissue0.96288980
75MP0004087_abnormal_muscle_fiber0.95950493
76MP0003119_abnormal_digestive_system0.95444511
77MP0003122_maternal_imprinting0.95332336
78MP0002109_abnormal_limb_morphology0.93287164
79MP0000759_abnormal_skeletal_muscle0.92415754
80MP0005171_absent_coat_pigmentation0.91825094
81MP0004084_abnormal_cardiac_muscle0.90186228
82MP0000747_muscle_weakness0.89823015
83MP0002925_abnormal_cardiovascular_devel0.89092292
84MP0004134_abnormal_chest_morphology0.88505755
85MP0002168_other_aberrant_phenotype0.88315692
86MP0002295_abnormal_pulmonary_circulatio0.88033148
87MP0003567_abnormal_fetal_cardiomyocyte0.87297167
88MP0010368_abnormal_lymphatic_system0.87107831
89MP0003300_gastrointestinal_ulcer0.86815958
90MP0002269_muscular_atrophy0.86559990
91MP0002796_impaired_skin_barrier0.85662448
92MP0000516_abnormal_urinary_system0.85122786
93MP0005367_renal/urinary_system_phenotyp0.85122786
94MP0002113_abnormal_skeleton_development0.84753100
95MP0001614_abnormal_blood_vessel0.84552870
96MP0005390_skeleton_phenotype0.84449087
97MP0002938_white_spotting0.84143218
98MP0004133_heterotaxia0.83802414
99MP0005197_abnormal_uvea_morphology0.83525951
100MP0000767_abnormal_smooth_muscle0.83071703
101MP0002092_abnormal_eye_morphology0.81971144
102MP0005187_abnormal_penis_morphology0.81608937
103MP0001661_extended_life_span0.81547076
104MP0006138_congestive_heart_failure0.81461478
105MP0006292_abnormal_olfactory_placode0.80920722
106MP0003045_fibrosis0.80277999
107MP0001915_intracranial_hemorrhage0.79525954
108MP0010386_abnormal_urinary_bladder0.79449279
109MP0001730_embryonic_growth_arrest0.78953310
110MP0000003_abnormal_adipose_tissue0.78397392
111MP0010771_integument_phenotype0.78250131
112MP0002128_abnormal_blood_circulation0.77813013
113MP0005369_muscle_phenotype0.77075096
114MP0001697_abnormal_embryo_size0.76716875
115MP0010630_abnormal_cardiac_muscle0.76086492
116MP0000013_abnormal_adipose_tissue0.75106863
117MP0004145_abnormal_muscle_electrophysio0.74704136
118MP0002088_abnormal_embryonic_growth/wei0.74622740
119MP0003984_embryonic_growth_retardation0.74342375
120MP0003448_altered_tumor_morphology0.71804228
121MP0008789_abnormal_olfactory_epithelium0.71658448
122MP0009840_abnormal_foam_cell0.71544661
123MP0005409_darkened_coat_color0.71009097
124MP0008004_abnormal_stomach_pH0.69196849
125MP0005193_abnormal_anterior_eye0.68069454
126MP0002133_abnormal_respiratory_system0.67974208
127MP0005388_respiratory_system_phenotype0.67974208
128MP0002998_abnormal_bone_remodeling0.65454676
129MP0005395_other_phenotype0.64521182
130MP0000467_abnormal_esophagus_morphology0.63044779
131MP0002177_abnormal_outer_ear0.62662873
132MP0000462_abnormal_digestive_system0.62285648
133MP0001175_abnormal_lung_morphology0.61748218
134MP0003453_abnormal_keratinocyte_physiol0.61712934

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.83905151
2Premature rupture of membranes (HP:0001788)5.66505866
3Shallow orbits (HP:0000586)4.51540482
4Ankle contracture (HP:0006466)4.49565413
5Broad metatarsal (HP:0001783)3.60400704
6Atrophic scars (HP:0001075)3.58942764
7Aortic dissection (HP:0002647)3.50851965
8* Natal tooth (HP:0000695)3.47599798
9Abnormality of dentin (HP:0010299)3.39105650
10Bladder diverticulum (HP:0000015)3.35116665
11Type 1 muscle fiber predominance (HP:0003803)3.34202120
12Soft skin (HP:0000977)3.34187737
13Cerebral aneurysm (HP:0004944)3.25852620
14Increased connective tissue (HP:0009025)3.22787962
15Cervical subluxation (HP:0003308)3.04598194
16Dilatation of the ascending aorta (HP:0005111)2.98233512
17Spondylolisthesis (HP:0003302)2.95962521
18Aortic aneurysm (HP:0004942)2.95167749
19Short 4th metacarpal (HP:0010044)2.93459098
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93459098
21Genu recurvatum (HP:0002816)2.88367948
22* Neonatal short-limb short stature (HP:0008921)2.86852816
23Mitral valve prolapse (HP:0001634)2.85784370
24Fragile skin (HP:0001030)2.85714012
25Spinal rigidity (HP:0003306)2.76587073
26Peritonitis (HP:0002586)2.70950057
27Follicular hyperkeratosis (HP:0007502)2.70788244
28Bowel diverticulosis (HP:0005222)2.66415951
29Aortic valve stenosis (HP:0001650)2.63793339
30Aortic regurgitation (HP:0001659)2.61796139
31Wrist flexion contracture (HP:0001239)2.60818709
32Mildly elevated creatine phosphokinase (HP:0008180)2.47598486
33Increased variability in muscle fiber diameter (HP:0003557)2.47002984
34Blue sclerae (HP:0000592)2.46729700
35Abnormality of the 4th metacarpal (HP:0010012)2.46359112
36Selective tooth agenesis (HP:0001592)2.43783442
37Wormian bones (HP:0002645)2.36778496
38Osteolytic defects of the hand bones (HP:0009699)2.30938261
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.30938261
40Deviation of the hallux (HP:0010051)2.30015625
41Coronal craniosynostosis (HP:0004440)2.29470793
42Biconcave vertebral bodies (HP:0004586)2.26558449
43Hyperextensible skin (HP:0000974)2.24632225
44Scapular winging (HP:0003691)2.21984162
45Limited hip movement (HP:0008800)2.21931024
46Slender build (HP:0001533)2.20748526
47Ulnar bowing (HP:0003031)2.20124492
48Persistence of primary teeth (HP:0006335)2.19071031
49Hallux valgus (HP:0001822)2.17047100
50Generalized amyotrophy (HP:0003700)2.15822980
51Abnormality of skeletal muscle fiber size (HP:0012084)2.15585467
52Lymphangioma (HP:0100764)2.14285668
53Renal duplication (HP:0000075)2.14134206
54Wide anterior fontanel (HP:0000260)2.12695291
55Thin bony cortex (HP:0002753)2.10040443
56* Advanced eruption of teeth (HP:0006288)2.08963490
57Round ear (HP:0100830)2.08188663
58Difficulty climbing stairs (HP:0003551)2.06026785
59Aneurysm (HP:0002617)2.04742524
60Vascular tortuosity (HP:0004948)2.04664050
61Ectopia lentis (HP:0001083)2.02491932
62Buphthalmos (HP:0000557)2.01624927
63Abnormality of the acetabulum (HP:0003170)2.01215832
64Hip contracture (HP:0003273)2.01115482
65Mesomelia (HP:0003027)2.00860463
66Camptodactyly of toe (HP:0001836)2.00458541
67Distal upper limb amyotrophy (HP:0007149)1.98309951
68Upper limb amyotrophy (HP:0009129)1.98309951
69Joint laxity (HP:0001388)1.97157760
70Broad long bones (HP:0005622)1.96740458
71Elbow flexion contracture (HP:0002987)1.95786875
72Delayed cranial suture closure (HP:0000270)1.95553322
73Overgrowth (HP:0001548)1.94534320
74Hypoplasia of the iris (HP:0007676)1.93437146
75Joint stiffness (HP:0001387)1.91425179
76Abnormality of the calcaneus (HP:0008364)1.89985440
77Vertebral compression fractures (HP:0002953)1.88449840
78Short nail (HP:0001799)1.88105099
79Abnormality of the phalanges of the hallux (HP:0010057)1.86260682
80Enlarged penis (HP:0000040)1.86050969
81Radial bowing (HP:0002986)1.84829519
82Bell-shaped thorax (HP:0001591)1.84313658
83Abnormality of the peritoneum (HP:0002585)1.83724148
84Turricephaly (HP:0000262)1.81810129
85Arterial tortuosity (HP:0005116)1.81545246
86Right ventricular cardiomyopathy (HP:0011663)1.80865678
87Syringomyelia (HP:0003396)1.80384593
88Spinal cord lesions (HP:0100561)1.80384593
89Popliteal pterygium (HP:0009756)1.80185845
90Flat cornea (HP:0007720)1.79778744
91Limb-girdle muscle weakness (HP:0003325)1.79637291
92Abnormal delivery (HP:0001787)1.79267822
93Knee flexion contracture (HP:0006380)1.77871037
94Bowing of the arm (HP:0006488)1.77119539
95Bowed forearm bones (HP:0003956)1.77119539
96Flexion contracture of toe (HP:0005830)1.75990924
97Joint contractures involving the joints of the feet (HP:0100492)1.75990924
98Protruding ear (HP:0000411)1.75032228
99Disproportionate tall stature (HP:0001519)1.74908746
100Keratoconus (HP:0000563)1.72334604
101Increased corneal curvature (HP:0100692)1.72334604
102Bronchomalacia (HP:0002780)1.72026462
103Delayed closure of the anterior fontanelle (HP:0001476)1.71593045
104Mild short stature (HP:0003502)1.70397930
105Broad ribs (HP:0000885)1.69688280
106Muscle fiber splitting (HP:0003555)1.69606636
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69097775
108Mitral regurgitation (HP:0001653)1.68872595
109Broad thumb (HP:0011304)1.68372389
110Infantile muscular hypotonia (HP:0008947)1.67089483
111Vertebral arch anomaly (HP:0008438)1.66564001
112Hand muscle atrophy (HP:0009130)1.66244959
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.65839185
114Tibial bowing (HP:0002982)1.65692043
115Aplasia involving bones of the extremities (HP:0009825)1.65357458
116Aplasia involving bones of the upper limbs (HP:0009823)1.65357458
117Aplasia of the phalanges of the hand (HP:0009802)1.65357458
118Absent frontal sinuses (HP:0002688)1.64277766
119Breech presentation (HP:0001623)1.64153609
120Ovoid vertebral bodies (HP:0003300)1.64113894
121Inguinal hernia (HP:0000023)1.64060471
122Achilles tendon contracture (HP:0001771)1.63560703
123* Emphysema (HP:0002097)1.63406603
124Broad phalanx (HP:0006009)1.62964103
125Rectal prolapse (HP:0002035)1.62684023
126Subacute progressive viral hepatitis (HP:0006572)1.61818428
127Long eyelashes (HP:0000527)1.61752182
128Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.60081947
129Hypoventilation (HP:0002791)1.60074167
130Tarsal synostosis (HP:0008368)1.59804736
131Morphological abnormality of the middle ear (HP:0008609)1.59768709
132Calcaneovalgus deformity (HP:0001848)1.58841937
133Increased density of long bones (HP:0006392)1.58381239
134Abnormality of the anterior chamber (HP:0000593)1.58356830
135Arachnodactyly (HP:0001166)1.57532754
136Pulmonary artery stenosis (HP:0004415)1.56391570
137Pterygium (HP:0001059)1.56186456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.09461426
2MYLK3.88367765
3DDR23.85491088
4TTN3.75561925
5PKN23.34982762
6LATS23.09063681
7PDGFRA2.96657451
8NEK92.85259905
9LATS12.84731609
10TIE12.42242485
11RIPK12.06560093
12PIK3CG2.04194285
13EEF2K2.03038216
14PRKD31.98946721
15NEK11.93744847
16PAK41.82828547
17BMX1.82293173
18AKT31.81462087
19CDK121.77406240
20SIK11.72258891
21EPHB21.69605044
22PAK21.68330399
23FER1.59188960
24EPHA21.53966587
25FGFR11.46409237
26BRSK21.46152498
27CAMK1G1.43437884
28MAP3K101.42733440
29PNCK1.40533264
30RPS6KA21.37138797
31PTK21.36841420
32MET1.33913431
33LRRK21.33678380
34STK38L1.32532329
35MAP4K21.30666318
36PTK61.24086498
37CDC71.21180776
38PAK31.20173077
39KIT1.19000110
40MTOR1.17614031
41MARK21.16667522
42PBK1.14125871
43WNK41.10891023
44FLT31.10797241
45TYRO31.09540503
46ILK1.08193821
47MAP3K61.07316339
48PTK2B1.07172102
49TGFBR11.06886594
50ABL21.06055187
51PLK41.04665330
52ERN11.04098701
53PAK60.98645602
54RPS6KL10.96468024
55RPS6KC10.96468024
56STK380.94812210
57DMPK0.94150092
58STK30.90890736
59KSR20.90712612
60MAP3K130.90691473
61RPS6KB20.89164679
62MAP3K30.88473165
63MAP3K80.88374088
64RPS6KA40.84204468
65CDK60.82546103
66PDGFRB0.81542587
67MELK0.79806316
68SMG10.79190178
69TTK0.78816789
70ROCK10.77614429
71MOS0.76698709
72ARAF0.76457119
73RPS6KA60.76267722
74CDK70.75604099
75LMTK20.75293741
76LIMK10.74490697
77NEK20.72886290
78MAP2K10.72882951
79KSR10.71256894
80ICK0.71167875
81GSK3A0.71021393
82FGFR20.69586895
83ERBB40.69431861
84MAPK70.69073553
85TRPM70.67493447
86PASK0.67412014
87PDK40.66170022
88PDK30.66170022
89ROCK20.65503607
90ALK0.65486432
91SCYL20.64150858
92WNK30.63499502
93MKNK10.62888353
94AKT20.61206203
95PRKG20.59616033
96MST1R0.58610032
97CDK90.58379363
98WNK10.57013513
99PRKD20.56352117
100JAK30.55339669
101NTRK10.54574096
102PAK10.53866017
103PLK20.53737179
104BRAF0.52835141
105WEE10.52183489
106AURKB0.50720410
107DAPK30.50216261
108RET0.48845245
109MUSK0.48738585
110NTRK30.47972623
111CAMKK10.47757181
112TGFBR20.47568137
113MAPKAPK30.47400952
114ERBB30.46922551
115CSNK1E0.46244471
116TESK10.44298747
117MAP3K90.43410979
118MAP2K30.42835234
119MAP3K70.42814617
120PRPF4B0.42401615
121PLK10.41769989
122ERBB20.41512243
123NME20.40531972
124INSR0.40504760
125PRKD10.38713622
126GRK50.38351770
127PDK20.37722109
128BCKDK0.37387117
129STK240.37034926
130PRKCI0.36239321
131PRKCH0.35762760
132MAPK10.35640675
133CDC42BPA0.35378730
134BRD40.34721668
135PLK30.34658974
136CDK150.34436944
137PIK3CA0.33646287
138SRC0.33249270
139TAOK20.32870646
140TEC0.32231687
141CHEK10.31827880
142CLK10.30684499
143ADRBK10.28837578
144ABL10.28189462
145SGK20.25878703
146PRKCE0.24407195
147CAMK1D0.23150077
148SGK30.22940761
149RPS6KA10.22922602

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.34521155
2Basal cell carcinoma_Homo sapiens_hsa052172.61643075
3Focal adhesion_Homo sapiens_hsa045102.60682869
4Hippo signaling pathway_Homo sapiens_hsa043902.27417458
5Proteoglycans in cancer_Homo sapiens_hsa052052.26483997
6Bladder cancer_Homo sapiens_hsa052192.23901006
7Protein digestion and absorption_Homo sapiens_hsa049742.18274135
8Hedgehog signaling pathway_Homo sapiens_hsa043402.16537958
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.08435601
10Adherens junction_Homo sapiens_hsa045202.00254439
11Dilated cardiomyopathy_Homo sapiens_hsa054141.80659292
12MicroRNAs in cancer_Homo sapiens_hsa052061.80294798
13TGF-beta signaling pathway_Homo sapiens_hsa043501.76994489
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72898160
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.69996769
16Small cell lung cancer_Homo sapiens_hsa052221.69785886
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60624460
18Tight junction_Homo sapiens_hsa045301.58810269
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.58213766
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57265780
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.57222991
22Melanoma_Homo sapiens_hsa052181.51620412
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.50940288
24Glioma_Homo sapiens_hsa052141.48422162
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44337092
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43886736
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43092959
28Melanogenesis_Homo sapiens_hsa049161.39024375
29Malaria_Homo sapiens_hsa051441.37732038
30Amoebiasis_Homo sapiens_hsa051461.37617168
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36949350
32Wnt signaling pathway_Homo sapiens_hsa043101.30033352
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28573108
34Chronic myeloid leukemia_Homo sapiens_hsa052201.28062123
35mTOR signaling pathway_Homo sapiens_hsa041501.21315165
36One carbon pool by folate_Homo sapiens_hsa006701.18096783
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16625874
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15716946
39Axon guidance_Homo sapiens_hsa043601.13853107
40Cell cycle_Homo sapiens_hsa041101.08552467
41Rap1 signaling pathway_Homo sapiens_hsa040151.08369751
42RNA transport_Homo sapiens_hsa030131.07598010
43Pathways in cancer_Homo sapiens_hsa052001.06895197
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.01062920
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00035676
46Gap junction_Homo sapiens_hsa045400.99012540
47p53 signaling pathway_Homo sapiens_hsa041150.96889887
48Homologous recombination_Homo sapiens_hsa034400.95669240
49Lysine degradation_Homo sapiens_hsa003100.94823780
50HIF-1 signaling pathway_Homo sapiens_hsa040660.94055709
51Notch signaling pathway_Homo sapiens_hsa043300.93832199
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93043333
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91831695
54GnRH signaling pathway_Homo sapiens_hsa049120.91096558
55Toxoplasmosis_Homo sapiens_hsa051450.90770553
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89392278
57Endometrial cancer_Homo sapiens_hsa052130.89324012
58Thyroid cancer_Homo sapiens_hsa052160.89155456
59Other glycan degradation_Homo sapiens_hsa005110.88696838
60Prostate cancer_Homo sapiens_hsa052150.87484796
61HTLV-I infection_Homo sapiens_hsa051660.86591514
62Estrogen signaling pathway_Homo sapiens_hsa049150.85310438
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85105096
64Biosynthesis of amino acids_Homo sapiens_hsa012300.84073806
65Oocyte meiosis_Homo sapiens_hsa041140.83837272
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82768864
67Shigellosis_Homo sapiens_hsa051310.80489717
68VEGF signaling pathway_Homo sapiens_hsa043700.78333396
69Non-small cell lung cancer_Homo sapiens_hsa052230.77865564
70Colorectal cancer_Homo sapiens_hsa052100.77242365
71Glucagon signaling pathway_Homo sapiens_hsa049220.76383022
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76010628
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75323698
74Dorso-ventral axis formation_Homo sapiens_hsa043200.75134709
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.75017824
76Viral myocarditis_Homo sapiens_hsa054160.74754682
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74591638
78Lysosome_Homo sapiens_hsa041420.73222726
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72828799
80AMPK signaling pathway_Homo sapiens_hsa041520.72800249
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71919768
82Sphingolipid metabolism_Homo sapiens_hsa006000.71796555
83Ovarian steroidogenesis_Homo sapiens_hsa049130.71253433
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70252548
85Carbon metabolism_Homo sapiens_hsa012000.69704984
86Oxytocin signaling pathway_Homo sapiens_hsa049210.69064115
87Endocytosis_Homo sapiens_hsa041440.68970071
88mRNA surveillance pathway_Homo sapiens_hsa030150.68356266
89Selenocompound metabolism_Homo sapiens_hsa004500.67588070
90Thyroid hormone synthesis_Homo sapiens_hsa049180.66338950
91Gastric acid secretion_Homo sapiens_hsa049710.66178781
92Prion diseases_Homo sapiens_hsa050200.63885118
93Pancreatic cancer_Homo sapiens_hsa052120.63087204
94Renal cell carcinoma_Homo sapiens_hsa052110.62973541
95MAPK signaling pathway_Homo sapiens_hsa040100.62565531
96Viral carcinogenesis_Homo sapiens_hsa052030.61567630
97Inositol phosphate metabolism_Homo sapiens_hsa005620.61068778
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60396773
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60271016
100Spliceosome_Homo sapiens_hsa030400.59318187
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.59243781
102ErbB signaling pathway_Homo sapiens_hsa040120.59187273
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59000973
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.58883562
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57551739
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56961935
107Platelet activation_Homo sapiens_hsa046110.56022491
108Insulin signaling pathway_Homo sapiens_hsa049100.54951645
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53873241
110TNF signaling pathway_Homo sapiens_hsa046680.53731399
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53204977
112Galactose metabolism_Homo sapiens_hsa000520.53007956
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52037437
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50528151
115Complement and coagulation cascades_Homo sapiens_hsa046100.49437768
116Long-term potentiation_Homo sapiens_hsa047200.49011900
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47830316
118Circadian rhythm_Homo sapiens_hsa047100.47541789
119Insulin resistance_Homo sapiens_hsa049310.47282828
120Systemic lupus erythematosus_Homo sapiens_hsa053220.45902089
121FoxO signaling pathway_Homo sapiens_hsa040680.45401982
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.43053816
123Ras signaling pathway_Homo sapiens_hsa040140.42658165
124Nucleotide excision repair_Homo sapiens_hsa034200.42291943
125Hepatitis B_Homo sapiens_hsa051610.41599553
126Apoptosis_Homo sapiens_hsa042100.39643627
127Mismatch repair_Homo sapiens_hsa034300.38034342
128ABC transporters_Homo sapiens_hsa020100.37611157
129Calcium signaling pathway_Homo sapiens_hsa040200.36298376
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35168129
131Base excision repair_Homo sapiens_hsa034100.33796947
132Fatty acid elongation_Homo sapiens_hsa000620.33676568
133N-Glycan biosynthesis_Homo sapiens_hsa005100.33345073
134Non-homologous end-joining_Homo sapiens_hsa034500.33270164
135Acute myeloid leukemia_Homo sapiens_hsa052210.33266025

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