EVI2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.24982787
2positive regulation of gamma-delta T cell activation (GO:0046645)6.19642793
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.81283005
4negative regulation of cell killing (GO:0031342)5.81283005
5ensheathment of neurons (GO:0007272)5.78178941
6axon ensheathment (GO:0008366)5.78178941
7myelination (GO:0042552)5.73523881
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.64700263
9long-chain fatty acid biosynthetic process (GO:0042759)5.36074260
10regulation of B cell receptor signaling pathway (GO:0050855)5.35448720
11myelin maintenance (GO:0043217)5.04943532
12neutrophil activation involved in immune response (GO:0002283)4.78223131
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.60496635
14regulation of gamma-delta T cell activation (GO:0046643)4.53883646
15response to lipoprotein particle (GO:0055094)4.52551744
16negative regulation of interleukin-12 production (GO:0032695)4.39720210
17antigen processing and presentation of endogenous antigen (GO:0019883)4.36049991
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33360755
19detection of other organism (GO:0098543)4.31441128
20positive regulation of oligodendrocyte differentiation (GO:0048714)4.22553896
21regulation of gamma-delta T cell differentiation (GO:0045586)4.19847524
22amyloid precursor protein metabolic process (GO:0042982)4.18542402
23response to peptidoglycan (GO:0032494)4.17412521
24detection of molecule of bacterial origin (GO:0032490)4.14674543
25L-amino acid import (GO:0043092)4.08125785
26negative regulation of neurotransmitter secretion (GO:0046929)4.04369180
27cellular extravasation (GO:0045123)3.99177534
28detection of bacterium (GO:0016045)3.93386275
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90769967
30creatine metabolic process (GO:0006600)3.90171490
31immunoglobulin mediated immune response (GO:0016064)3.89792473
32leukocyte aggregation (GO:0070486)3.88813365
33oligodendrocyte differentiation (GO:0048709)3.88710316
34detection of external biotic stimulus (GO:0098581)3.88639125
35negative regulation of protein localization to cell surface (GO:2000009)3.84240644
36negative T cell selection (GO:0043383)3.81997486
37regulation of collateral sprouting (GO:0048670)3.81236164
38negative regulation of neurotransmitter transport (GO:0051589)3.80375491
39amyloid precursor protein catabolic process (GO:0042987)3.79904881
40response to interleukin-15 (GO:0070672)3.76084917
41negative thymic T cell selection (GO:0045060)3.75068014
42positive regulation of mast cell activation (GO:0033005)3.74249801
43regulation of T cell tolerance induction (GO:0002664)3.68269769
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.66967715
45negative regulation of T cell mediated immunity (GO:0002710)3.66657586
46import into cell (GO:0098657)3.64578082
47positive thymic T cell selection (GO:0045059)3.64526184
48glycerophospholipid catabolic process (GO:0046475)3.64448577
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.63575417
50cellular response to interleukin-15 (GO:0071350)3.60432694
51positive regulation of B cell differentiation (GO:0045579)3.58441059
52B cell receptor signaling pathway (GO:0050853)3.57695189
53regulation of tolerance induction (GO:0002643)3.55835466
54leukocyte migration involved in inflammatory response (GO:0002523)3.52344854
55detection of biotic stimulus (GO:0009595)3.51527207
56macrophage activation (GO:0042116)3.46701918
57cholesterol biosynthetic process (GO:0006695)3.46450061
58T cell migration (GO:0072678)3.44908087
59positive T cell selection (GO:0043368)3.42269436
60response to methylmercury (GO:0051597)3.42267047
61adhesion of symbiont to host cell (GO:0044650)3.41721396
62virion attachment to host cell (GO:0019062)3.41721396
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39208308
64response to host immune response (GO:0052572)3.39208308
65glycosylceramide metabolic process (GO:0006677)3.38873022
66regulation of B cell differentiation (GO:0045577)3.38758678
67regulation of mast cell degranulation (GO:0043304)3.38559432
68negative regulation of leukocyte mediated immunity (GO:0002704)3.37220123
69regulation of alpha-beta T cell proliferation (GO:0046640)3.35928900
70positive regulation of mast cell degranulation (GO:0043306)3.35541031
71positive regulation of mast cell activation involved in immune response (GO:0033008)3.35541031
72interferon-gamma-mediated signaling pathway (GO:0060333)3.35198912
73membrane raft organization (GO:0031579)3.34724351
74antigen processing and presentation via MHC class Ib (GO:0002475)3.33956248
75establishment of mitochondrion localization (GO:0051654)3.33092100
76regulation of mast cell activation (GO:0033003)3.27185971
77tolerance induction (GO:0002507)3.22384372
78T cell selection (GO:0045058)3.21954284
79neutrophil mediated immunity (GO:0002446)3.19846294
80modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19057605
81positive regulation by organism of defense response of other organism involved in symbiotic interact3.19057605
82modulation by symbiont of host immune response (GO:0052553)3.19057605
83positive regulation by symbiont of host defense response (GO:0052509)3.19057605
84modulation by symbiont of host defense response (GO:0052031)3.19057605
85modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19057605
86regulation of regulatory T cell differentiation (GO:0045589)3.18884642
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.15862015
88regulation of mast cell activation involved in immune response (GO:0033006)3.14162153
89B cell mediated immunity (GO:0019724)3.11989512
90response to muramyl dipeptide (GO:0032495)3.11362698
91astrocyte development (GO:0014002)3.09437762
92GPI anchor biosynthetic process (GO:0006506)3.08514143
93regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08095566
94sterol biosynthetic process (GO:0016126)3.07416343
95response to host (GO:0075136)3.07106223
96response to host defenses (GO:0052200)3.07106223
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.07106223
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06761199
99lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06282077
100positive regulation of interleukin-17 production (GO:0032740)3.06043865
101microglial cell activation (GO:0001774)3.05912949
102regulation of T cell mediated cytotoxicity (GO:0001914)3.01442460
103interferon-gamma production (GO:0032609)3.01279526
104isoprenoid biosynthetic process (GO:0008299)3.00004229
105positive regulation of tolerance induction (GO:0002645)2.99991105
106negative regulation of macroautophagy (GO:0016242)2.99247412
107regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.98972812
108regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98849141
109type I interferon signaling pathway (GO:0060337)2.98771723
110cellular response to type I interferon (GO:0071357)2.98771723
111neutrophil activation (GO:0042119)2.98498916
112regulation of lipoprotein metabolic process (GO:0050746)2.98281703
113positive regulation of toll-like receptor signaling pathway (GO:0034123)2.97700737
114positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96860055
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96662561
116eye photoreceptor cell differentiation (GO:0001754)2.96492967
117photoreceptor cell differentiation (GO:0046530)2.96492967
118regulation of leukocyte degranulation (GO:0043300)2.94855592
119response to type I interferon (GO:0034340)2.94813446
120defense response to protozoan (GO:0042832)2.93844150
121respiratory burst (GO:0045730)2.93725341
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93696099
123amino acid import (GO:0043090)2.93331221
124myeloid leukocyte mediated immunity (GO:0002444)2.92413091
125long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.91823985
126asymmetric protein localization (GO:0008105)2.90999479
127antigen receptor-mediated signaling pathway (GO:0050851)2.90959290
128regulation of natural killer cell mediated immunity (GO:0002715)2.90276582
129regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90276582
130GPI anchor metabolic process (GO:0006505)2.90180016
131myeloid leukocyte activation (GO:0002274)2.88391235
132positive regulation of glial cell differentiation (GO:0045687)2.88153451
133regulation of T-helper 2 cell differentiation (GO:0045628)2.87880448
134positive regulation of gliogenesis (GO:0014015)2.87591482
135thymic T cell selection (GO:0045061)2.86645773
136regulation of interleukin-17 production (GO:0032660)2.86089744
137production of molecular mediator involved in inflammatory response (GO:0002532)2.85941694
138membrane tubulation (GO:0097320)2.85598547
139granulocyte activation (GO:0036230)2.83177078
140protein palmitoylation (GO:0018345)2.80462214
141apical protein localization (GO:0045176)2.77147734
142response to redox state (GO:0051775)2.74079569
143mast cell activation (GO:0045576)2.71147357
144magnesium ion transport (GO:0015693)2.70729369
145long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.70310271
146presynaptic membrane organization (GO:0097090)2.68645417
147axon development (GO:0061564)2.66788000
148substantia nigra development (GO:0021762)2.64384130
149regulation of T cell migration (GO:2000404)2.64256687
150adhesion of symbiont to host (GO:0044406)2.62181561
151negative regulation of acute inflammatory response (GO:0002674)2.62044577
152positive regulation of monocyte chemotaxis (GO:0090026)2.61748277
153myeloid cell activation involved in immune response (GO:0002275)2.60788226
154intracellular pH reduction (GO:0051452)2.60264531
155negative regulation of execution phase of apoptosis (GO:1900118)2.58011030
156macrophage activation involved in immune response (GO:0002281)2.55954421
157nerve growth factor signaling pathway (GO:0038180)2.55019998
158regulation of lymphocyte migration (GO:2000401)2.54793157
159adult walking behavior (GO:0007628)2.51451913
160protein localization to endosome (GO:0036010)2.51118283
161negative regulation of interleukin-17 production (GO:0032700)2.49651554
162activated T cell proliferation (GO:0050798)2.47556183
163tissue regeneration (GO:0042246)2.46083624
164T-helper 1 type immune response (GO:0042088)2.44503812
165preassembly of GPI anchor in ER membrane (GO:0016254)2.44132089
166pH reduction (GO:0045851)2.43736094
167membrane protein ectodomain proteolysis (GO:0006509)2.43642562
168negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.41821492
169fatty-acyl-CoA biosynthetic process (GO:0046949)2.41198714
170peptidyl-tyrosine autophosphorylation (GO:0038083)2.40413098
171positive regulation of T cell cytokine production (GO:0002726)2.38959306
172positive regulation of type 2 immune response (GO:0002830)2.38689397
173positive regulation of pseudopodium assembly (GO:0031274)2.38390210
174neuron remodeling (GO:0016322)2.38308010
175cortical actin cytoskeleton organization (GO:0030866)2.38235346
176leukocyte degranulation (GO:0043299)2.37740433
177positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.35221217
178regulation of interferon-beta biosynthetic process (GO:0045357)2.32457440
179negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.30658963
180glial cell development (GO:0021782)2.30434928
181central nervous system myelination (GO:0022010)10.6952339
182axon ensheathment in central nervous system (GO:0032291)10.6952339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.86339081
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.22480919
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.77652333
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35227005
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.03867771
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94824970
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.83135845
8MYB_26560356_Chip-Seq_TH2_Human2.78824249
9SPI1_23547873_ChIP-Seq_NB4_Human2.61096860
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56408796
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.44280769
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39076413
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.35856594
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19838883
15VDR_24763502_ChIP-Seq_THP-1_Human2.17454982
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15100912
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11719621
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.11308622
19GBX2_23144817_ChIP-Seq_PC3_Human2.10737563
20* MYB_26560356_Chip-Seq_TH1_Human2.08492810
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03605102
22MAF_26560356_Chip-Seq_TH1_Human2.03177228
23GATA3_27048872_Chip-Seq_THYMUS_Human1.94744959
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93349752
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.90683709
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83630653
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79892877
28VDR_21846776_ChIP-Seq_THP-1_Human1.79709830
29UTX_26944678_Chip-Seq_JUKART_Human1.78084645
30TAF15_26573619_Chip-Seq_HEK293_Human1.72729770
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72112674
32GATA3_26560356_Chip-Seq_TH2_Human1.70774043
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69340093
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68490248
35NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.66611168
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63359868
37* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61108247
38ER_23166858_ChIP-Seq_MCF-7_Human1.60245097
39RUNX_20019798_ChIP-Seq_JUKART_Human1.56320066
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56063742
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53520417
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48470320
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46203435
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45974586
45MAF_26560356_Chip-Seq_TH2_Human1.44429043
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43614710
47* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41123766
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40767656
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40767656
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39119819
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.39098237
52VDR_24787735_ChIP-Seq_THP-1_Human1.38305550
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38049438
54AR_21572438_ChIP-Seq_LNCaP_Human1.37943542
55* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37313489
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36970023
57MYC_22102868_ChIP-Seq_BL_Human1.33456605
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33248680
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32839640
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32628163
61GATA1_22025678_ChIP-Seq_K562_Human1.30501880
62TCF7_22412390_ChIP-Seq_EML_Mouse1.29842828
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29201815
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27135393
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.26568991
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26069068
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.24327683
68VDR_22108803_ChIP-Seq_LS180_Human1.23481631
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23169488
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22067714
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21821423
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21746868
73* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21585403
74* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20966644
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17858969
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17369887
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16178299
78* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15254828
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15107375
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14219886
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13261973
82* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12582568
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.11931967
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10639973
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10496832
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10334171
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10104460
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09766658
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09402394
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08842422
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08613320
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07527559
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07475086
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.06981812
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06097819
96EGR1_19032775_ChIP-ChIP_M12_Human1.05848820
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05532191
98KDM2B_26808549_Chip-Seq_DND41_Human1.04672827
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.03511091
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.02134739
101* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01022362
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00421734
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00345714
104* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99940985
105P300_18555785_Chip-Seq_ESCs_Mouse0.99851559
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99393702
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.98337958
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96051646
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95716194
110VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95110531
111SCL_19346495_ChIP-Seq_HPC-7_Human0.95013026
112DROSHA_22980978_ChIP-Seq_HELA_Human0.94364552
113* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93589431
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93512282
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.93380441
116EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93022043
117RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93022043
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91820250
119SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91277391
120SPI1_23127762_ChIP-Seq_K562_Human0.91126736
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90862638
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90581051
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88546183
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87794734
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87777874
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87356765
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.87350633
128P300_19829295_ChIP-Seq_ESCs_Human0.87322187
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87307007
130GATA1_19941826_ChIP-Seq_K562_Human0.86793350
131SMRT_27268052_Chip-Seq_Bcells_Human0.86534162
132EZH2_27294783_Chip-Seq_ESCs_Mouse0.86482599
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86146307
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85354728
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85169276
136EOMES_21245162_ChIP-Seq_HESCs_Human0.85010804
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.84692970
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84605848
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84306998
140GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84075877
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83251250
142GATA2_19941826_ChIP-Seq_K562_Human0.82956863
143* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82349127
144* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82278780
145KLF4_18555785_Chip-Seq_ESCs_Mouse0.82171213
146SOX2_18555785_Chip-Seq_ESCs_Mouse0.81182903
147IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80841342
148NANOG_19829295_ChIP-Seq_ESCs_Human0.80778173
149SOX2_19829295_ChIP-Seq_ESCs_Human0.80778173
150PU1_27457419_Chip-Seq_LIVER_Mouse0.80729386
151P53_22387025_ChIP-Seq_ESCs_Mouse0.80674598
152PU_27001747_Chip-Seq_BMDM_Mouse0.80661826
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.80401831
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.80366522
155EED_16625203_ChIP-ChIP_MESCs_Mouse0.79449199
156RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74335438
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.71797609
158GATA1_19941827_ChIP-Seq_MEL86_Mouse0.70443270
159SPI1_20517297_ChIP-Seq_HL60_Human0.68767733
160STAT1_20625510_ChIP-Seq_HELA_Human0.68602078
161TFEB_21752829_ChIP-Seq_HELA_Human0.65720169
162GATA3_26560356_Chip-Seq_TH1_Human0.65655794
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.63360113
164TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.61757498
165RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.61237789
166BCL6_27268052_Chip-Seq_Bcells_Human0.60450943
167ETS1_22383799_ChIP-Seq_G1ME_Mouse0.58863340
168STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.57208974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.74201390
2MP0003690_abnormal_glial_cell3.90053897
3MP0003950_abnormal_plasma_membrane3.86161060
4MP0005058_abnormal_lysosome_morphology3.43766830
5MP0006082_CNS_inflammation3.26961993
6MP0005171_absent_coat_pigmentation2.68417979
7MP0001835_abnormal_antigen_presentation2.57540256
8MP0003763_abnormal_thymus_physiology2.50826260
9MP0003136_yellow_coat_color2.35838043
10MP0003634_abnormal_glial_cell2.31357437
11MP0002148_abnormal_hypersensitivity_rea2.27266315
12MP0003329_amyloid_beta_deposits2.22158332
13MP0003880_abnormal_central_pattern2.17588563
14MP0000604_amyloidosis2.16160223
15MP0003300_gastrointestinal_ulcer2.15545273
16MP0004742_abnormal_vestibular_system2.14408692
17MP0002419_abnormal_innate_immunity2.12838870
18MP0005000_abnormal_immune_tolerance2.12647111
19MP0009840_abnormal_foam_cell2.03132933
20MP0002398_abnormal_bone_marrow1.94125615
21MP0001790_abnormal_immune_system1.89996517
22MP0005387_immune_system_phenotype1.89996517
23MP0009785_altered_susceptibility_to1.85155368
24MP0001905_abnormal_dopamine_level1.83094480
25MP0005671_abnormal_response_to1.82763924
26MP0010155_abnormal_intestine_physiology1.78737928
27MP0004270_analgesia1.76857524
28MP0005409_darkened_coat_color1.76688284
29MP0003303_peritoneal_inflammation1.75805347
30MP0003724_increased_susceptibility_to1.75532262
31MP0004142_abnormal_muscle_tone1.73120261
32MP0005025_abnormal_response_to1.72679783
33MP0001529_abnormal_vocalization1.72403480
34MP0005451_abnormal_body_composition1.68320867
35MP0005410_abnormal_fertilization1.66532579
36MP0008260_abnormal_autophagy1.66293817
37MP0004885_abnormal_endolymph1.64049877
38MP0003866_abnormal_defecation1.62031004
39MP0009764_decreased_sensitivity_to1.61907657
40MP0000689_abnormal_spleen_morphology1.61869536
41MP0004381_abnormal_hair_follicle1.61475773
42MP0002723_abnormal_immune_serum1.59220917
43MP0001851_eye_inflammation1.59087362
44MP0003828_pulmonary_edema1.58939325
45MP0002166_altered_tumor_susceptibility1.57738323
46MP0003436_decreased_susceptibility_to1.57207411
47MP0003172_abnormal_lysosome_physiology1.55690612
48MP0002722_abnormal_immune_system1.55215633
49MP0003632_abnormal_nervous_system1.54226200
50MP0001853_heart_inflammation1.52548044
51MP0002229_neurodegeneration1.51448770
52MP0002429_abnormal_blood_cell1.50551311
53MP0003075_altered_response_to1.50226733
54MP0002272_abnormal_nervous_system1.50131772
55MP0000383_abnormal_hair_follicle1.49076750
56MP0002452_abnormal_antigen_presenting1.48678586
57MP0001486_abnormal_startle_reflex1.48421927
58MP0000569_abnormal_digit_pigmentation1.46253816
59MP0002064_seizures1.44099915
60MP0000703_abnormal_thymus_morphology1.43442533
61MP0005310_abnormal_salivary_gland1.41429111
62MP0010678_abnormal_skin_adnexa1.40665030
63MP0001800_abnormal_humoral_immune1.39053244
64MP0002933_joint_inflammation1.31429179
65MP0003631_nervous_system_phenotype1.30679112
66MP0000685_abnormal_immune_system1.30134422
67MP0001533_abnormal_skeleton_physiology1.29003233
68MP0003633_abnormal_nervous_system1.28000157
69MP0001819_abnormal_immune_cell1.26347916
70MP0002420_abnormal_adaptive_immunity1.25998890
71MP0001485_abnormal_pinna_reflex1.24776554
72MP0009278_abnormal_bone_marrow1.24075944
73MP0000858_altered_metastatic_potential1.22647781
74MP0008438_abnormal_cutaneous_collagen1.19691813
75MP0004883_abnormal_blood_vessel1.16906308
76MP0004043_abnormal_pH_regulation1.14999003
77MP0000465_gastrointestinal_hemorrhage1.14400580
78MP0004134_abnormal_chest_morphology1.14225180
79MP0003191_abnormal_cellular_cholesterol1.12404092
80MP0003195_calcinosis1.11045595
81MP0004510_myositis1.10961854
82MP0002006_tumorigenesis1.09715318
83MP0001545_abnormal_hematopoietic_system1.06857409
84MP0005397_hematopoietic_system_phenotyp1.06857409
85MP0005464_abnormal_platelet_physiology1.06675085
86MP0002132_abnormal_respiratory_system1.03199449
87MP0002396_abnormal_hematopoietic_system1.01541675
88MP0003806_abnormal_nucleotide_metabolis0.98221954
89MP0009046_muscle_twitch0.95377370
90MP0002998_abnormal_bone_remodeling0.95225117
91MP0003656_abnormal_erythrocyte_physiolo0.94030044
92MP0005164_abnormal_response_to0.93514364
93MP0005075_abnormal_melanosome_morpholog0.93022704
94MP0002277_abnormal_respiratory_mucosa0.92850109
95MP0005423_abnormal_somatic_nervous0.92635319
96MP0000778_abnormal_nervous_system0.92072674
97MP0003045_fibrosis0.88449109
98MP0002405_respiratory_system_inflammati0.87829654
99MP0002295_abnormal_pulmonary_circulatio0.87201837
100MP0009763_increased_sensitivity_to0.86497949
101MP0001346_abnormal_lacrimal_gland0.86135706
102MP0001873_stomach_inflammation0.85140673
103MP0008004_abnormal_stomach_pH0.84211314
104MP0002009_preneoplasia0.84050431
105MP0000015_abnormal_ear_pigmentation0.80943929
106MP0002090_abnormal_vision0.79750639
107MP0000716_abnormal_immune_system0.78076999
108MP0001963_abnormal_hearing_physiology0.77912294
109MP0001348_abnormal_lacrimal_gland0.77874443
110MP0000343_altered_response_to0.77677670
111MP0009333_abnormal_splenocyte_physiolog0.77274506
112MP0008469_abnormal_protein_level0.76229336
113MP0003448_altered_tumor_morphology0.74212943
114MP0001845_abnormal_inflammatory_respons0.74147317
115MP0008569_lethality_at_weaning0.73537994
116MP0001970_abnormal_pain_threshold0.72427827
117MP0003183_abnormal_peptide_metabolism0.70670687
118MP0005390_skeleton_phenotype0.70450642
119MP0002133_abnormal_respiratory_system0.68937895
120MP0005388_respiratory_system_phenotype0.68937895
121MP0002066_abnormal_motor_capabilities/c0.68766815
122MP0009745_abnormal_behavioral_response0.67840124
123MP0000249_abnormal_blood_vessel0.67548266
124MP0008874_decreased_physiological_sensi0.67290273
125MP0000747_muscle_weakness0.67246669
126MP0004947_skin_inflammation0.67181118
127MP0005408_hypopigmentation0.66852562
128MP0005166_decreased_susceptibility_to0.66482074
129MP0005195_abnormal_posterior_eye0.66471651
130MP0001663_abnormal_digestive_system0.66241454
131MP0004808_abnormal_hematopoietic_stem0.66112174
132MP0005167_abnormal_blood-brain_barrier0.65704000
133MP0004185_abnormal_adipocyte_glucose0.65506364
134MP0002882_abnormal_neuron_morphology0.65408871
135MP0000462_abnormal_digestive_system0.65401666
136MP0003795_abnormal_bone_structure0.65299963
137MP0009765_abnormal_xenobiotic_induced0.63968511
138MP0001986_abnormal_taste_sensitivity0.54172597
139MP0000371_diluted_coat_color0.53421153
140MP0008873_increased_physiological_sensi0.52269387
141MP0004130_abnormal_muscle_cell0.52145568
142MP0005174_abnormal_tail_pigmentation0.51028469
143MP0006054_spinal_hemorrhage0.49827483
144MP0002693_abnormal_pancreas_physiology0.47154149

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.26699553
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.86761293
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.86761293
4Myositis (HP:0100614)5.12252135
5Retrobulbar optic neuritis (HP:0100654)4.81415260
6Optic neuritis (HP:0100653)4.81415260
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.74127546
8Orchitis (HP:0100796)4.72980021
9Parakeratosis (HP:0001036)4.61380317
10Axonal loss (HP:0003447)4.59461423
11T lymphocytopenia (HP:0005403)4.42114073
12Cerebral inclusion bodies (HP:0100314)4.25879461
13Abnormality of T cell number (HP:0011839)4.24360552
14Recurrent fungal infections (HP:0002841)4.22644526
15Peripheral hypomyelination (HP:0007182)4.14320183
16Mediastinal lymphadenopathy (HP:0100721)4.13897574
17Abnormality of the corticospinal tract (HP:0002492)4.10586915
18Supranuclear gaze palsy (HP:0000605)3.99233517
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.90437895
20Meningitis (HP:0001287)3.87070737
21Recurrent abscess formation (HP:0002722)3.83762300
22Onion bulb formation (HP:0003383)3.78899999
23Chronic mucocutaneous candidiasis (HP:0002728)3.77898443
24Recurrent cutaneous fungal infections (HP:0011370)3.77898443
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.77469960
26Hepatosplenomegaly (HP:0001433)3.71928194
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.70980709
28Segmental peripheral demyelination/remyelination (HP:0003481)3.65700727
29Abnormality of macrophages (HP:0004311)3.64437063
30Increased cerebral lipofuscin (HP:0011813)3.63851759
31Sensory axonal neuropathy (HP:0003390)3.56682489
32Vasculitis (HP:0002633)3.51960483
33Recurrent bacterial skin infections (HP:0005406)3.49520388
34Encephalitis (HP:0002383)3.49325768
35Keratoconjunctivitis sicca (HP:0001097)3.49109569
36Gastrointestinal infarctions (HP:0005244)3.48849581
37Pulmonary infiltrates (HP:0002113)3.46405977
38Vacuolated lymphocytes (HP:0001922)3.42972654
39Recurrent viral infections (HP:0004429)3.30781370
40Spontaneous hematomas (HP:0007420)3.29706392
41Abnormality of T cells (HP:0002843)3.28205961
42Hemoptysis (HP:0002105)3.24234170
43Keratoconjunctivitis (HP:0001096)3.21674559
44Gingivitis (HP:0000230)3.18318811
45Abnormal auditory evoked potentials (HP:0006958)3.11017204
46Abnormality of liposaccharide metabolism (HP:0010968)3.10361774
47Abnormality of glycosphingolipid metabolism (HP:0004343)3.10361774
48Abnormality of glycolipid metabolism (HP:0010969)3.10361774
49Stomatitis (HP:0010280)3.07780625
50Leukocytosis (HP:0001974)3.02620638
51Urticaria (HP:0001025)2.98692055
52Chest pain (HP:0100749)2.96399164
53Loss of speech (HP:0002371)2.94619251
54Pulmonary embolism (HP:0002204)2.94232893
55Autoimmune thrombocytopenia (HP:0001973)2.93580335
56Slow saccadic eye movements (HP:0000514)2.90951325
57Clumsiness (HP:0002312)2.88472929
58Autoimmune hemolytic anemia (HP:0001890)2.86582178
59Increased IgM level (HP:0003496)2.83994724
60Arterial thrombosis (HP:0004420)2.75522537
61Systemic lupus erythematosus (HP:0002725)2.73689811
62Panhypogammaglobulinemia (HP:0003139)2.73261715
63Congenital ichthyosiform erythroderma (HP:0007431)2.73046953
64Spastic gait (HP:0002064)2.72180199
65Recurrent skin infections (HP:0001581)2.71632848
66Peripheral demyelination (HP:0011096)2.71312119
67Cerebral hypomyelination (HP:0006808)2.70166667
68Progressive neurologic deterioration (HP:0002344)2.68494142
69Insidious onset (HP:0003587)2.67410897
70Termporal pattern (HP:0011008)2.67410897
71Cellulitis (HP:0100658)2.65570126
72Eczematoid dermatitis (HP:0000976)2.64054411
73White forelock (HP:0002211)2.62917886
74Pustule (HP:0200039)2.61701834
75Dysostosis multiplex (HP:0000943)2.57714149
76Granulocytopenia (HP:0001913)2.57233997
77Patchy hypopigmentation of hair (HP:0011365)2.55105462
78Gingival bleeding (HP:0000225)2.54090530
79Gangrene (HP:0100758)2.53884412
80Alacrima (HP:0000522)2.53069774
81Intention tremor (HP:0002080)2.52931630
82Spastic tetraparesis (HP:0001285)2.52249877
83IgG deficiency (HP:0004315)2.50999000
84Eosinophilia (HP:0001880)2.50919576
85Increased IgE level (HP:0003212)2.50478233
86Abnormality of T cell physiology (HP:0011840)2.49832909
87Epistaxis (HP:0000421)2.49201813
88Prolonged neonatal jaundice (HP:0006579)2.48586503
89Dysmetria (HP:0001310)2.45670656
90Abnormality of the prostate (HP:0008775)2.42816201
91Inflammation of the large intestine (HP:0002037)2.42734432
92Abnormality of eosinophils (HP:0001879)2.42333602
93Autoamputation (HP:0001218)2.41773905
94Cerebral hemorrhage (HP:0001342)2.41673613
95Premature skin wrinkling (HP:0100678)2.41632199
96Episodic fever (HP:0001954)2.41528845
97Stridor (HP:0010307)2.40863994
98Prolonged bleeding time (HP:0003010)2.40707143
99Recurrent bronchitis (HP:0002837)2.39341525
100Abnormality of the pleura (HP:0002103)2.37324432
101Osteomyelitis (HP:0002754)2.34389638
102Agammaglobulinemia (HP:0004432)2.32797589
103Severe combined immunodeficiency (HP:0004430)2.31211581
104Lymphopenia (HP:0001888)2.27029188
105Gastrointestinal inflammation (HP:0004386)2.25572353
106Polyneuropathy (HP:0001271)2.24961738
107Disinhibition (HP:0000734)2.23773106
108Anorexia (HP:0002039)2.23503906
109Leukodystrophy (HP:0002415)2.23383627
110Neuronal loss in central nervous system (HP:0002529)2.20086324
111Obstructive lung disease (HP:0006536)2.18842077
112Chronic obstructive pulmonary disease (HP:0006510)2.18842077
113Chronic otitis media (HP:0000389)2.18555787
114Hypergammaglobulinemia (HP:0010702)2.18541277
115Colitis (HP:0002583)2.17718689
116Absent septum pellucidum (HP:0001331)2.17686188
117Abnormality of cells of the lymphoid lineage (HP:0012140)2.17132353
118Thickened helices (HP:0000391)2.16134548
119Chronic diarrhea (HP:0002028)2.15526048
120Akinesia (HP:0002304)2.15523175
121Erythroderma (HP:0001019)2.13082487
122Glomerulopathy (HP:0100820)2.12735944
123Abnormality of B cell number (HP:0010975)2.12476731
124IgM deficiency (HP:0002850)2.12180651
125Retinal dysplasia (HP:0007973)2.12050449
126Vertigo (HP:0002321)2.11687295
127Sepsis (HP:0100806)2.07520287
128Amyloidosis (HP:0011034)2.07207807
129Urinary incontinence (HP:0000020)2.06885655
130Recurrent gram-negative bacterial infections (HP:0005420)2.06222853
131Thick nail (HP:0001805)2.05769319
132Anteriorly placed anus (HP:0001545)2.05568858
133Ankle clonus (HP:0011448)2.04744864
134Paraparesis (HP:0002385)2.04520854
135Hypoplasia of the iris (HP:0007676)2.04513380
136Combined immunodeficiency (HP:0005387)2.04451223
137Spastic paraparesis (HP:0002313)2.04231084
138Stomach cancer (HP:0012126)2.03019054
139Petechiae (HP:0000967)2.01250162
140Elevated erythrocyte sedimentation rate (HP:0003565)2.00438234
141Hypoplastic pelvis (HP:0008839)2.00185304
142Abnormality of glycolysis (HP:0004366)2.00184353
143Increased serum pyruvate (HP:0003542)2.00184353
144Decreased lacrimation (HP:0000633)1.99942505
145Memory impairment (HP:0002354)1.95372662
146Metabolic alkalosis (HP:0200114)1.93752372
147Joint swelling (HP:0001386)1.92373681
148Premature loss of primary teeth (HP:0006323)1.90919995
149Foot dorsiflexor weakness (HP:0009027)1.88933424
150Amaurosis fugax (HP:0100576)1.88358320
151Osteolytic defects of the hand bones (HP:0009699)1.88119774
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.88119774
153Glomerulonephritis (HP:0000099)1.87841589
154Abnormality of the endocardium (HP:0004306)1.87357223
155Recurrent pneumonia (HP:0006532)1.86737734
156Skin rash (HP:0000988)1.85716265
157Scanning speech (HP:0002168)1.85197669
158Mutism (HP:0002300)1.83560104
159Muscle fiber splitting (HP:0003555)1.81502577
160Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81254839
161Duplicated collecting system (HP:0000081)1.80660164
162Abnormality of the septum pellucidum (HP:0007375)1.79608315
163Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79512383
164Abolished electroretinogram (ERG) (HP:0000550)1.78414668
165Gowers sign (HP:0003391)1.75616758
166Hypophosphatemic rickets (HP:0004912)1.74837892
167CNS hypomyelination (HP:0003429)1.74736769
168Decreased motor nerve conduction velocity (HP:0003431)1.73948627
169Morphological abnormality of the inner ear (HP:0011390)1.72075462
170Partial duplication of thumb phalanx (HP:0009944)1.71544718
171Split foot (HP:0001839)1.69663525
172Purpura (HP:0000979)1.69257547
173Myokymia (HP:0002411)1.67920276
174J-shaped sella turcica (HP:0002680)1.66517530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.56315188
2OXSR13.98617847
3EPHB13.63703557
4PBK3.21119170
5PKN12.89543269
6TAOK32.62507768
7BLK2.48367993
8MAPKAPK52.43968348
9ZAP702.11194096
10BCR2.03325880
11MAP2K32.00994305
12GRK61.99254282
13CLK11.96989434
14CDK191.95873374
15LIMK11.90672830
16JAK31.90353556
17MET1.89271866
18WNK11.87202086
19FGR1.86393400
20MST41.85600133
21WNK41.79558534
22TESK21.73517517
23TEC1.67509174
24FGFR21.57934533
25MAP3K141.56523787
26TNK21.50913122
27NEK61.50212073
28JAK21.49668234
29MAP3K131.45858753
30CSNK1A1L1.45191005
31CAMKK21.45054727
32CSNK1G31.41794455
33IRAK41.36370176
34CAMK2B1.27522071
35CSF1R1.23436405
36RIPK41.23204837
37ROCK21.20226943
38GRK71.19949446
39MAP4K11.16209482
40UHMK11.16152090
41TRPM71.15499844
42ITK1.11792959
43ERN11.11743619
44MAP3K31.11213644
45PRPF4B1.08035121
46KIT1.07920452
47CAMK2D1.07504785
48PRKCQ1.05737500
49MAP3K111.05438174
50MATK1.05091044
51CSNK1G11.04803059
52IRAK21.03438061
53MAP3K11.00275720
54NTRK10.99680522
55IKBKB0.97231119
56ARAF0.95958440
57CSK0.94933140
58MAPK150.94077184
59MARK30.93003086
60TBK10.92060514
61KSR20.91877057
62CAMKK10.89612911
63CSNK1G20.89163094
64YES10.88888203
65BMPR1B0.88785947
66SIK30.88311099
67TXK0.87906955
68LCK0.82459877
69CAMK2G0.81455200
70PIK3CG0.81314914
71TYK20.80907185
72FES0.80011064
73IKBKE0.76921208
74PRKD10.76730375
75RPS6KA50.75006553
76BMPR20.74728719
77FGFR30.73744673
78PDPK10.73004209
79MOS0.71153156
80PNCK0.70745441
81SGK2230.70597223
82SGK4940.70597223
83ADRBK20.70408007
84TAOK10.69247739
85PAK60.68957921
86MAP3K20.68247775
87HCK0.67755334
88FYN0.67119071
89DYRK20.66704467
90MAPK120.63804813
91PIM10.63022500
92LYN0.62607315
93TGFBR20.60451313
94DAPK20.59002531
95MAP3K50.58260624
96GSK3A0.57400178
97TNIK0.56282250
98CAMK2A0.55235895
99ICK0.55227554
100SYK0.55122285
101STK100.55117091
102MAP2K60.54079358
103PRKCE0.54025275
104SGK20.52692090
105MUSK0.52402141
106CDK50.52006877
107NLK0.51928250
108SGK30.51587681
109DMPK0.51077780
110JAK10.50401624
111PDK10.50144820
112BTK0.49940398
113PRKCH0.49582779
114MARK20.49177930
115HIPK20.48941777
116TAOK20.48266808
117CASK0.47385514
118CDK140.47045539
119ACVR1B0.46440624
120BMX0.45408779
121PRKG10.44966578
122IRAK10.44417850
123IRAK30.44007806
124SIK20.43628380
125LRRK20.43254877
126CDK150.42299035
127MAP3K60.41511314
128PTK2B0.41153351
129MAPK70.40791451
130RAF10.39966933
131ABL10.39762476
132CDK60.39411255
133CSNK1D0.38657180
134MAP2K20.38579517
135CDK180.36099313
136INSR0.36046709
137ERBB40.35855999
138CAMK1G0.35722056
139CDK11A0.35316363
140STK110.35032044
141PAK10.34868149
142DAPK30.34815694
143MAP3K120.34563873
144RET0.33668845
145MAPKAPK20.32318831
146EGFR0.30575003
147PRKCD0.30106163
148CAMK40.28806421
149RPS6KL10.28452999
150RPS6KC10.28452999
151KSR10.28138154
152CDC42BPA0.27824603
153RPS6KA60.26209331
154DYRK1B0.26061951
155CHUK0.25541706

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.03557674
2Steroid biosynthesis_Homo sapiens_hsa001004.00371849
3Fatty acid elongation_Homo sapiens_hsa000623.58890202
4Ether lipid metabolism_Homo sapiens_hsa005652.99353034
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.77912522
6Lysosome_Homo sapiens_hsa041422.26040051
7Antigen processing and presentation_Homo sapiens_hsa046122.14863801
8Staphylococcus aureus infection_Homo sapiens_hsa051502.06529756
9Graft-versus-host disease_Homo sapiens_hsa053322.02382515
10Sphingolipid metabolism_Homo sapiens_hsa006001.98597721
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98442235
12Rheumatoid arthritis_Homo sapiens_hsa053231.84081862
13Allograft rejection_Homo sapiens_hsa053301.77493182
14Histidine metabolism_Homo sapiens_hsa003401.71831161
15Malaria_Homo sapiens_hsa051441.70738683
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68281190
17Protein export_Homo sapiens_hsa030601.68051894
18Viral myocarditis_Homo sapiens_hsa054161.66666782
19Vitamin B6 metabolism_Homo sapiens_hsa007501.57682664
20Autoimmune thyroid disease_Homo sapiens_hsa053201.54472009
21Legionellosis_Homo sapiens_hsa051341.54275106
22Phagosome_Homo sapiens_hsa041451.53243392
23Influenza A_Homo sapiens_hsa051641.44567723
24Asthma_Homo sapiens_hsa053101.41238391
25Pertussis_Homo sapiens_hsa051331.41180754
26Leishmaniasis_Homo sapiens_hsa051401.35680428
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34549231
28Other glycan degradation_Homo sapiens_hsa005111.32035794
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31064644
30TNF signaling pathway_Homo sapiens_hsa046681.30238711
31Linoleic acid metabolism_Homo sapiens_hsa005911.27371189
32Herpes simplex infection_Homo sapiens_hsa051681.27137612
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.24087166
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21726706
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17103702
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16658627
37Sulfur metabolism_Homo sapiens_hsa009201.16615507
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15071882
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15071624
40Salmonella infection_Homo sapiens_hsa051321.14999820
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14456651
42Osteoclast differentiation_Homo sapiens_hsa043801.12671936
43Sphingolipid signaling pathway_Homo sapiens_hsa040711.11126398
44B cell receptor signaling pathway_Homo sapiens_hsa046621.10711991
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.09886761
46Acute myeloid leukemia_Homo sapiens_hsa052211.09814730
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.09510555
48Chemokine signaling pathway_Homo sapiens_hsa040621.08445297
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.07180412
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05394225
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01346546
52Hepatitis B_Homo sapiens_hsa051610.98171833
53Tuberculosis_Homo sapiens_hsa051520.96582873
54Arachidonic acid metabolism_Homo sapiens_hsa005900.96005512
55Oxidative phosphorylation_Homo sapiens_hsa001900.95849452
56Renal cell carcinoma_Homo sapiens_hsa052110.95702646
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93622183
58Collecting duct acid secretion_Homo sapiens_hsa049660.92257356
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90966345
60Endocytosis_Homo sapiens_hsa041440.89089574
61Axon guidance_Homo sapiens_hsa043600.89031487
62Nitrogen metabolism_Homo sapiens_hsa009100.88579213
63Apoptosis_Homo sapiens_hsa042100.85861659
64Non-small cell lung cancer_Homo sapiens_hsa052230.83550168
65African trypanosomiasis_Homo sapiens_hsa051430.83212053
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83173377
67Hematopoietic cell lineage_Homo sapiens_hsa046400.80303598
68Vibrio cholerae infection_Homo sapiens_hsa051100.79237575
69Prion diseases_Homo sapiens_hsa050200.76773727
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.75091476
71Mineral absorption_Homo sapiens_hsa049780.73309310
72Shigellosis_Homo sapiens_hsa051310.72984742
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72839451
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72799426
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71690779
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71552075
77Arginine and proline metabolism_Homo sapiens_hsa003300.71337621
78Serotonergic synapse_Homo sapiens_hsa047260.69681530
79Primary immunodeficiency_Homo sapiens_hsa053400.69096881
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.66586912
81T cell receptor signaling pathway_Homo sapiens_hsa046600.65857391
82VEGF signaling pathway_Homo sapiens_hsa043700.65029675
83Epstein-Barr virus infection_Homo sapiens_hsa051690.64407499
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64058135
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62516403
86Pancreatic cancer_Homo sapiens_hsa052120.62214220
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61462217
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61185551
89Alzheimers disease_Homo sapiens_hsa050100.60474269
90Folate biosynthesis_Homo sapiens_hsa007900.58818526
91Prolactin signaling pathway_Homo sapiens_hsa049170.58712212
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58351621
93Measles_Homo sapiens_hsa051620.57241864
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56864268
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.54443361
96Ras signaling pathway_Homo sapiens_hsa040140.53735284
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53602811
98Type I diabetes mellitus_Homo sapiens_hsa049400.52954275
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52546775
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52375487
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52310729
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52208397
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51942760
104Chronic myeloid leukemia_Homo sapiens_hsa052200.50309022
105Long-term depression_Homo sapiens_hsa047300.50265277
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49755407
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45700846
108Long-term potentiation_Homo sapiens_hsa047200.44353069
109MAPK signaling pathway_Homo sapiens_hsa040100.44174607
110GABAergic synapse_Homo sapiens_hsa047270.43853238
111FoxO signaling pathway_Homo sapiens_hsa040680.43830707
112GnRH signaling pathway_Homo sapiens_hsa049120.43804963
113Morphine addiction_Homo sapiens_hsa050320.43674055
114Glutamatergic synapse_Homo sapiens_hsa047240.43402392
115HTLV-I infection_Homo sapiens_hsa051660.43393296
116Viral carcinogenesis_Homo sapiens_hsa052030.43293661
117Hepatitis C_Homo sapiens_hsa051600.43140878
118Regulation of autophagy_Homo sapiens_hsa041400.42108976
119Parkinsons disease_Homo sapiens_hsa050120.41768642
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41159458
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.40907215
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40222780
123HIF-1 signaling pathway_Homo sapiens_hsa040660.39919211
124Toxoplasmosis_Homo sapiens_hsa051450.38018586
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37671481
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.37249091
127Vitamin digestion and absorption_Homo sapiens_hsa049770.37240256
128Dorso-ventral axis formation_Homo sapiens_hsa043200.34686699
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34229484
130Platelet activation_Homo sapiens_hsa046110.31530205
131Ovarian steroidogenesis_Homo sapiens_hsa049130.31000555
132Choline metabolism in cancer_Homo sapiens_hsa052310.30972702
133Glutathione metabolism_Homo sapiens_hsa004800.30440764
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.29725073
135Amoebiasis_Homo sapiens_hsa051460.29657862
136Systemic lupus erythematosus_Homo sapiens_hsa053220.29297290
137Type II diabetes mellitus_Homo sapiens_hsa049300.29199959
138Inositol phosphate metabolism_Homo sapiens_hsa005620.28902290
139Renin secretion_Homo sapiens_hsa049240.28662664
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28101741
141Estrogen signaling pathway_Homo sapiens_hsa049150.26948913
142mTOR signaling pathway_Homo sapiens_hsa041500.26751054
143Rap1 signaling pathway_Homo sapiens_hsa040150.23237696

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