EVI5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54889318
2L-phenylalanine catabolic process (GO:0006559)6.54889318
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.18449685
4L-phenylalanine metabolic process (GO:0006558)6.18449685
5aromatic amino acid family catabolic process (GO:0009074)5.91946784
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.52633517
7cysteine metabolic process (GO:0006534)5.46958460
8urea metabolic process (GO:0019627)5.41264456
9urea cycle (GO:0000050)5.41264456
10bile acid biosynthetic process (GO:0006699)5.38027196
11indolalkylamine catabolic process (GO:0046218)5.35754202
12tryptophan catabolic process (GO:0006569)5.35754202
13indole-containing compound catabolic process (GO:0042436)5.35754202
14kynurenine metabolic process (GO:0070189)5.31224236
15regulation of protein activation cascade (GO:2000257)5.27247799
16complement activation, alternative pathway (GO:0006957)5.23928676
17tryptophan metabolic process (GO:0006568)5.18020052
18serine family amino acid catabolic process (GO:0009071)5.12316411
19negative regulation of fibrinolysis (GO:0051918)5.11495099
20glyoxylate metabolic process (GO:0046487)5.00906349
21alpha-linolenic acid metabolic process (GO:0036109)4.98410093
22regulation of complement activation (GO:0030449)4.96906015
23nitrogen cycle metabolic process (GO:0071941)4.92036575
24regulation of fibrinolysis (GO:0051917)4.90704910
25peptidyl-glutamic acid carboxylation (GO:0017187)4.89708710
26protein carboxylation (GO:0018214)4.89708710
27high-density lipoprotein particle remodeling (GO:0034375)4.77115812
28sulfur amino acid catabolic process (GO:0000098)4.75163052
29homocysteine metabolic process (GO:0050667)4.72351668
30lysine catabolic process (GO:0006554)4.60999445
31lysine metabolic process (GO:0006553)4.60999445
32bile acid metabolic process (GO:0008206)4.52046936
33tyrosine metabolic process (GO:0006570)4.47237436
34reverse cholesterol transport (GO:0043691)4.44138866
35aromatic amino acid family metabolic process (GO:0009072)4.37182663
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.26409362
37glutamate metabolic process (GO:0006536)4.26363619
38cellular ketone body metabolic process (GO:0046950)4.26247732
39amino-acid betaine metabolic process (GO:0006577)4.25074366
40alpha-amino acid catabolic process (GO:1901606)4.23861775
41protein-lipid complex remodeling (GO:0034368)4.22982667
42macromolecular complex remodeling (GO:0034367)4.22982667
43plasma lipoprotein particle remodeling (GO:0034369)4.22982667
44bile acid and bile salt transport (GO:0015721)4.17499946
45regulation of cholesterol esterification (GO:0010872)4.10615826
46dicarboxylic acid biosynthetic process (GO:0043650)4.09502564
47glycine metabolic process (GO:0006544)4.05665730
48triglyceride homeostasis (GO:0070328)4.04909245
49acylglycerol homeostasis (GO:0055090)4.04909245
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.01670446
51serine family amino acid metabolic process (GO:0009069)3.98000030
52indolalkylamine metabolic process (GO:0006586)3.93087768
53phospholipid efflux (GO:0033700)3.92974048
54regulation of triglyceride catabolic process (GO:0010896)3.91624410
55cellular amino acid catabolic process (GO:0009063)3.89888701
56negative regulation of cytosolic calcium ion concentration (GO:0051481)3.89668052
57drug catabolic process (GO:0042737)3.83102384
58plasma lipoprotein particle clearance (GO:0034381)3.82223715
59cellular modified amino acid catabolic process (GO:0042219)3.79267532
60cholesterol efflux (GO:0033344)3.78860880
61negative regulation of sterol transport (GO:0032372)3.78663608
62negative regulation of cholesterol transport (GO:0032375)3.78663608
63negative regulation of protein activation cascade (GO:2000258)3.74248150
64fibrinolysis (GO:0042730)3.71227961
65ketone body metabolic process (GO:1902224)3.70191915
66coenzyme catabolic process (GO:0009109)3.69608544
67low-density lipoprotein particle remodeling (GO:0034374)3.68901589
68imidazole-containing compound metabolic process (GO:0052803)3.67631902
69urate metabolic process (GO:0046415)3.65514329
70phospholipid homeostasis (GO:0055091)3.65460523
71plasma lipoprotein particle assembly (GO:0034377)3.64086034
72benzene-containing compound metabolic process (GO:0042537)3.60246886
73cellular glucuronidation (GO:0052695)3.60081321
74arginine metabolic process (GO:0006525)3.59030811
75complement activation (GO:0006956)3.58078355
76regulation of cholesterol homeostasis (GO:2000188)3.57790403
77complement activation, classical pathway (GO:0006958)3.55779851
78regulation of bile acid biosynthetic process (GO:0070857)3.54033921
79positive regulation of fatty acid beta-oxidation (GO:0032000)3.54023675
80positive regulation of lipid catabolic process (GO:0050996)3.51635256
81serine family amino acid biosynthetic process (GO:0009070)3.51361151
82very-low-density lipoprotein particle assembly (GO:0034379)3.48164990
83cellular biogenic amine catabolic process (GO:0042402)3.48136742
84amine catabolic process (GO:0009310)3.48136742
85protein activation cascade (GO:0072376)3.44464285
86ethanol oxidation (GO:0006069)3.42794204
87epithelial cilium movement (GO:0003351)3.42617413
88atrial cardiac muscle cell action potential (GO:0086014)3.36912940
89protein-lipid complex assembly (GO:0065005)3.34023797
90cilium movement (GO:0003341)3.30894356
91aspartate family amino acid catabolic process (GO:0009068)3.27668713
92blood coagulation, intrinsic pathway (GO:0007597)3.27328545
93organic acid catabolic process (GO:0016054)3.26217306
94carboxylic acid catabolic process (GO:0046395)3.26217306
95acetyl-CoA metabolic process (GO:0006084)3.25021970
96short-chain fatty acid metabolic process (GO:0046459)3.24961402
97proline transport (GO:0015824)3.23886564
98lipoprotein metabolic process (GO:0042157)3.23790635
99exogenous drug catabolic process (GO:0042738)3.22810682
100plasma lipoprotein particle organization (GO:0071827)3.21398569
101negative regulation of fatty acid biosynthetic process (GO:0045717)3.19812365
102sterol homeostasis (GO:0055092)3.19724807
103cholesterol homeostasis (GO:0042632)3.18869331
104uronic acid metabolic process (GO:0006063)3.15593565
105glucuronate metabolic process (GO:0019585)3.15593565
106L-fucose metabolic process (GO:0042354)3.11042045
107L-fucose catabolic process (GO:0042355)3.11042045
108fucose catabolic process (GO:0019317)3.11042045
109aldehyde catabolic process (GO:0046185)3.10556216
110water-soluble vitamin biosynthetic process (GO:0042364)3.09534835
111gamma-aminobutyric acid transport (GO:0015812)3.07835320
112cilium morphogenesis (GO:0060271)3.04349252
113regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.93277293
114response to pheromone (GO:0019236)2.90705426
115intraciliary transport (GO:0042073)2.88580312
116establishment of protein localization to Golgi (GO:0072600)2.86946125
117cilium or flagellum-dependent cell motility (GO:0001539)2.86221138
118cilium organization (GO:0044782)2.84991469
119establishment of nucleus localization (GO:0040023)2.82353666
120cilium assembly (GO:0042384)2.81905968
121neural tube formation (GO:0001841)2.80405155
122regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.80034322
123kidney morphogenesis (GO:0060993)2.79474984
124axoneme assembly (GO:0035082)2.79336758
125negative regulation of axon guidance (GO:1902668)2.78247213
126detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77963543
127limb bud formation (GO:0060174)2.72566815
128negative regulation of axon extension involved in axon guidance (GO:0048843)2.67937136
129regulation of protein glycosylation (GO:0060049)2.67003801
130signal peptide processing (GO:0006465)2.66222002
131negative regulation of systemic arterial blood pressure (GO:0003085)2.65123350
132nonmotile primary cilium assembly (GO:0035058)2.64596757
133retinal ganglion cell axon guidance (GO:0031290)2.63512335
134inner ear receptor stereocilium organization (GO:0060122)2.63108852
135vascular smooth muscle contraction (GO:0014829)2.60515086
136sulfation (GO:0051923)2.58796934
137behavioral response to nicotine (GO:0035095)2.58034810
138regulation of cilium movement (GO:0003352)2.57648995
139platelet dense granule organization (GO:0060155)2.57388880
140lymphangiogenesis (GO:0001946)2.57255370
141regulation of glucokinase activity (GO:0033131)2.56579451
142regulation of hexokinase activity (GO:1903299)2.56579451
143nucleus localization (GO:0051647)2.56266299
144transmission of nerve impulse (GO:0019226)2.54950604
145purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.54840657
1463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.54840657
147photoreceptor cell maintenance (GO:0045494)2.52836372
148Golgi to endosome transport (GO:0006895)2.51475242
149presynaptic membrane assembly (GO:0097105)2.50817086
150nucleobase catabolic process (GO:0046113)2.50588239
151cellular component assembly involved in morphogenesis (GO:0010927)2.45673305
152negative chemotaxis (GO:0050919)2.45200551
153protein targeting to Golgi (GO:0000042)2.45187459
154auditory receptor cell differentiation (GO:0042491)2.44742695
155artery development (GO:0060840)2.43693095
156cerebral cortex radially oriented cell migration (GO:0021799)2.43193650
157sequestering of extracellular ligand from receptor (GO:0035581)2.43139597
158behavioral response to ethanol (GO:0048149)2.43124920
159pyrimidine nucleobase catabolic process (GO:0006208)2.42920546
160cornea development in camera-type eye (GO:0061303)2.42146622
161axonemal dynein complex assembly (GO:0070286)2.41267255
162left/right axis specification (GO:0070986)2.37717005
163phasic smooth muscle contraction (GO:0014821)2.35968984
164UDP-N-acetylglucosamine metabolic process (GO:0006047)2.35341815
165regulation of hippo signaling (GO:0035330)2.33552082
166negative regulation of protein localization to cell surface (GO:2000009)2.31997374
167prenylation (GO:0097354)2.30115764
168protein prenylation (GO:0018342)2.30115764
169thyroid hormone metabolic process (GO:0042403)2.29734183
170detection of light stimulus involved in visual perception (GO:0050908)2.28897963
171detection of light stimulus involved in sensory perception (GO:0050962)2.28897963
172pericardium development (GO:0060039)2.28599775
173cellular response to sterol (GO:0036315)2.28031473
174prostate gland growth (GO:0060736)2.27328123
175smooth muscle tissue development (GO:0048745)2.26708087
176neuronal action potential (GO:0019228)2.26564029
177protein K11-linked deubiquitination (GO:0035871)2.24105162
178interkinetic nuclear migration (GO:0022027)2.23990360
179negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.23987233
180magnesium ion transport (GO:0015693)2.23716342
181smooth muscle contraction (GO:0006939)2.22865336
182determination of left/right symmetry (GO:0007368)2.22593786
183positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.22315055
184membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.22176349
185regulation of non-canonical Wnt signaling pathway (GO:2000050)2.22058668
186regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.21338305
187C4-dicarboxylate transport (GO:0015740)2.21101545
188myelin assembly (GO:0032288)2.19798362
189retrograde transport, vesicle recycling within Golgi (GO:0000301)2.19257204
190calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.18022552
191dopamine transport (GO:0015872)2.17842172
192peristalsis (GO:0030432)2.17084472
193presynaptic membrane organization (GO:0097090)2.16767647
194nephron epithelium morphogenesis (GO:0072088)2.16135633
195nephron tubule morphogenesis (GO:0072078)2.16135633

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.64457208
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.21857946
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.10730776
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.09276895
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.89410275
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.92758696
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.47570060
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.86737129
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75773807
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67796653
11VDR_22108803_ChIP-Seq_LS180_Human2.35561865
12ZNF274_21170338_ChIP-Seq_K562_Hela2.22939582
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.18133930
14FUS_26573619_Chip-Seq_HEK293_Human2.12198323
15IGF1R_20145208_ChIP-Seq_DFB_Human2.09247451
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.07071667
17EWS_26573619_Chip-Seq_HEK293_Human1.93909430
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83021574
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75685575
20OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72708101
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72250799
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70183241
23* FOXA2_19822575_ChIP-Seq_HepG2_Human1.70006481
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.66680598
25CLOCK_20551151_ChIP-Seq_293T_Human1.63793533
26ER_23166858_ChIP-Seq_MCF-7_Human1.60538235
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59064300
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56671510
29* TCF4_23295773_ChIP-Seq_U87_Human1.55468727
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.55067010
31EZH2_22144423_ChIP-Seq_EOC_Human1.52912885
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52900070
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50790845
34TAF15_26573619_Chip-Seq_HEK293_Human1.50238553
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.48821056
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44268410
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43813573
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40810812
39* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40763048
40ZNF263_19887448_ChIP-Seq_K562_Human1.40664771
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.39560145
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37505377
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37222976
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35091779
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34797625
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34797625
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34083887
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.33820961
49P53_22387025_ChIP-Seq_ESCs_Mouse1.31698310
50GBX2_23144817_ChIP-Seq_PC3_Human1.30823438
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28736197
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.28073968
53TP53_18474530_ChIP-ChIP_U2OS_Human1.28053019
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28046734
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27482891
56RUNX2_22187159_ChIP-Seq_PCA_Human1.26866777
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25729800
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24953412
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24283906
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23545982
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22832070
62BCAT_22108803_ChIP-Seq_LS180_Human1.22005032
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21061826
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21061826
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20975927
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19988849
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.19981806
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19856478
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.18599161
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.17331683
71HTT_18923047_ChIP-ChIP_STHdh_Human1.17115848
72* NANOG_19829295_ChIP-Seq_ESCs_Human1.16705929
73* SOX2_19829295_ChIP-Seq_ESCs_Human1.16705929
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15311112
75* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14415554
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14378432
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13620590
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13535271
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.13329055
80JUN_21703547_ChIP-Seq_K562_Human1.13185511
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12501888
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.11992660
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11804115
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.11008457
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10922944
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.10624379
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.10280043
88P300_18555785_Chip-Seq_ESCs_Mouse1.09224628
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08574449
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08512468
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06233880
92SMAD4_21799915_ChIP-Seq_A2780_Human1.06045142
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05661100
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04657270
95* PRDM14_20953172_ChIP-Seq_ESCs_Human1.04657085
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.03443518
97TP53_16413492_ChIP-PET_HCT116_Human1.02082712
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01979102
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00739940
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98360079
101* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96998493
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94615223
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.92757677
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92584108
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91746998
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90931956
107CDX2_22108803_ChIP-Seq_LS180_Human0.90345195
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90171195
109* STAT3_23295773_ChIP-Seq_U87_Human0.89616954
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88010379
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86556541
112P300_19829295_ChIP-Seq_ESCs_Human0.86380071
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86183697
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85854942
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85112251
116SMAD_19615063_ChIP-ChIP_OVARY_Human0.83312098
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83110929
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82324464
119* SOX2_21211035_ChIP-Seq_LN229_Gbm0.81749393
120AR_21572438_ChIP-Seq_LNCaP_Human0.81555564
121* AR_25329375_ChIP-Seq_VCAP_Human0.79811303
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78427340
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78196269
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77662270
125GATA1_22025678_ChIP-Seq_K562_Human0.77353144
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76480348
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.76021041
128AR_21909140_ChIP-Seq_LNCAP_Human0.74992023
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73906268
130AHR_22903824_ChIP-Seq_MCF-7_Human0.73385846
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.72995121
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.72327971
133RXR_22108803_ChIP-Seq_LS180_Human0.71781255
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.71734067
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71576260
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.71306786
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.71021074
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.70478295
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.70459345
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.70117118
141TCF4_22108803_ChIP-Seq_LS180_Human0.69958422
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.69288602
143* AR_19668381_ChIP-Seq_PC3_Human0.68712055
144TP63_23658742_ChIP-Seq_EP156T_Human0.66990679
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66933877
146SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.65971133
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.65766429
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.65451233
149CJUN_26792858_Chip-Seq_BT549_Human0.64998587
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64039621
151MTF2_20144788_ChIP-Seq_MESCs_Mouse0.63575098
152CBP_20019798_ChIP-Seq_JUKART_Human0.63374029
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.63374029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.86310059
2MP0005360_urolithiasis7.19561761
3MP0005085_abnormal_gallbladder_physiolo6.16045592
4MP0005365_abnormal_bile_salt5.88972438
5MP0008875_abnormal_xenobiotic_pharmacok4.77344142
6MP0003252_abnormal_bile_duct3.95728445
7MP0000569_abnormal_digit_pigmentation3.87603288
8MP0010329_abnormal_lipoprotein_level3.34300872
9MP0003806_abnormal_nucleotide_metabolis3.05078958
10MP0005332_abnormal_amino_acid2.63547035
11MP0005083_abnormal_biliary_tract2.55385972
12MP0009840_abnormal_foam_cell2.51873129
13MP0010386_abnormal_urinary_bladder2.48604590
14MP0003195_calcinosis2.43562844
15MP0003868_abnormal_feces_composition2.31622470
16MP0003950_abnormal_plasma_membrane2.30580392
17MP0006054_spinal_hemorrhage2.19368705
18MP0001666_abnormal_nutrient_absorption2.13966616
19MP0003705_abnormal_hypodermis_morpholog2.12594102
20MP0005551_abnormal_eye_electrophysiolog2.06005275
21MP0002938_white_spotting2.01688831
22MP0002138_abnormal_hepatobiliary_system2.01219162
23MP0004019_abnormal_vitamin_homeostasis1.96829803
24MP0002102_abnormal_ear_morphology1.93777046
25MP0005171_absent_coat_pigmentation1.90408118
26MP0005174_abnormal_tail_pigmentation1.89872100
27MP0000609_abnormal_liver_physiology1.86538653
28MP0002118_abnormal_lipid_homeostasis1.85738536
29MP0003191_abnormal_cellular_cholesterol1.80690751
30MP0009046_muscle_twitch1.78848396
31MP0006072_abnormal_retinal_apoptosis1.76415364
32MP0009697_abnormal_copulation1.68867480
33MP0005253_abnormal_eye_physiology1.65952012
34MP0000383_abnormal_hair_follicle1.65763743
35MP0001984_abnormal_olfaction1.65211271
36MP0004885_abnormal_endolymph1.64897898
37MP0001485_abnormal_pinna_reflex1.64547846
38MP0002638_abnormal_pupillary_reflex1.62793412
39MP0010368_abnormal_lymphatic_system1.56131840
40MP0004043_abnormal_pH_regulation1.48800074
41MP0000647_abnormal_sebaceous_gland1.47856940
42MP0010678_abnormal_skin_adnexa1.43046047
43MP0000778_abnormal_nervous_system1.39740260
44MP0001486_abnormal_startle_reflex1.38714022
45MP0005319_abnormal_enzyme/_coenzyme1.37996722
46MP0005451_abnormal_body_composition1.37950868
47MP0009053_abnormal_anal_canal1.37562217
48MP0003880_abnormal_central_pattern1.37291637
49MP0003890_abnormal_embryonic-extraembry1.35402794
50MP0004215_abnormal_myocardial_fiber1.35185350
51MP0000631_abnormal_neuroendocrine_gland1.35046309
52MP0008877_abnormal_DNA_methylation1.33880904
53MP0003937_abnormal_limbs/digits/tail_de1.33636564
54MP0005408_hypopigmentation1.32675103
55MP0002234_abnormal_pharynx_morphology1.30980207
56MP0004142_abnormal_muscle_tone1.28302865
57MP0003656_abnormal_erythrocyte_physiolo1.27292611
58MP0002272_abnormal_nervous_system1.26225526
59MP0001299_abnormal_eye_distance/1.23933023
60MP0003136_yellow_coat_color1.23324888
61MP0005647_abnormal_sex_gland1.20292048
62MP0005386_behavior/neurological_phenoty1.19770210
63MP0004924_abnormal_behavior1.19770210
64MP0005367_renal/urinary_system_phenotyp1.18988441
65MP0000516_abnormal_urinary_system1.18988441
66MP0000372_irregular_coat_pigmentation1.16623132
67MP0005195_abnormal_posterior_eye1.15735260
68MP0002095_abnormal_skin_pigmentation1.15014322
69MP0003283_abnormal_digestive_organ1.14294913
70MP0005584_abnormal_enzyme/coenzyme_acti1.14172028
71MP0009745_abnormal_behavioral_response1.13557811
72MP0009384_cardiac_valve_regurgitation1.13541696
73MP0002751_abnormal_autonomic_nervous1.12552898
74MP0000013_abnormal_adipose_tissue1.12024479
75MP0005646_abnormal_pituitary_gland1.10424070
76MP0002909_abnormal_adrenal_gland1.08578255
77MP0004133_heterotaxia1.08390820
78MP0002233_abnormal_nose_morphology1.08116328
79MP0008775_abnormal_heart_ventricle1.07093218
80MP0001501_abnormal_sleep_pattern1.06820378
81MP0002254_reproductive_system_inflammat1.06729402
82MP0000604_amyloidosis1.02468018
83MP0002557_abnormal_social/conspecific_i1.02183719
84MP0005248_abnormal_Harderian_gland1.01620176
85MP0006276_abnormal_autonomic_nervous1.01317992
86MP0001324_abnormal_eye_pigmentation1.00947505
87MP0000015_abnormal_ear_pigmentation0.98065610
88MP0003755_abnormal_palate_morphology0.97611079
89MP0004484_altered_response_of0.96983526
90MP0004085_abnormal_heartbeat0.96915547
91MP0002822_catalepsy0.96195360
92MP0000639_abnormal_adrenal_gland0.95947196
93MP0004147_increased_porphyrin_level0.95758536
94MP0005187_abnormal_penis_morphology0.95129608
95MP0003045_fibrosis0.94304660
96MP0002090_abnormal_vision0.93298407
97MP0000598_abnormal_liver_morphology0.92034271
98MP0009643_abnormal_urine_homeostasis0.91867599
99MP0005503_abnormal_tendon_morphology0.90574693
100MP0001661_extended_life_span0.90508192
101MP0005645_abnormal_hypothalamus_physiol0.89975123
102MP0010234_abnormal_vibrissa_follicle0.89467208
103MP0001286_abnormal_eye_development0.89247393
104MP0005395_other_phenotype0.89058472
105MP0003329_amyloid_beta_deposits0.87138881
106MP0002160_abnormal_reproductive_system0.87054067
107MP0002184_abnormal_innervation0.87026233
108MP0002572_abnormal_emotion/affect_behav0.86822254
109MP0005391_vision/eye_phenotype0.86818977
110MP0002752_abnormal_somatic_nervous0.86727634
111MP0002282_abnormal_trachea_morphology0.86490552
112MP0001764_abnormal_homeostasis0.86203275
113MP0003935_abnormal_craniofacial_develop0.86086831
114MP0004130_abnormal_muscle_cell0.85657181
115MP0000026_abnormal_inner_ear0.85207521
116MP0002067_abnormal_sensory_capabilities0.85136514
117MP0001293_anophthalmia0.83814403
118MP0002229_neurodegeneration0.82563048
119MP0003718_maternal_effect0.82068134
120MP0002653_abnormal_ependyma_morphology0.81683632
121MP0005084_abnormal_gallbladder_morpholo0.78349511
122MP0002168_other_aberrant_phenotype0.77893474
123MP0003690_abnormal_glial_cell0.74035805
124MP0005167_abnormal_blood-brain_barrier0.72459661
125MP0005636_abnormal_mineral_homeostasis0.71296621
126MP0001756_abnormal_urination0.67000079
127MP0009780_abnormal_chondrocyte_physiolo0.66766382
128MP0002078_abnormal_glucose_homeostasis0.66257769
129MP0002971_abnormal_brown_adipose0.66235232
130MP0002928_abnormal_bile_duct0.64858622
131MP0003186_abnormal_redox_activity0.64419016
132MP0002876_abnormal_thyroid_physiology0.63912541
133MP0009764_decreased_sensitivity_to0.62763077
134MP0004185_abnormal_adipocyte_glucose0.61758179
135MP0005535_abnormal_body_temperature0.61060052
136MP0004858_abnormal_nervous_system0.60256347
137MP0003011_delayed_dark_adaptation0.59465243
138MP0009763_increased_sensitivity_to0.58644373
139MP0005220_abnormal_exocrine_pancreas0.57350110
140MP0009642_abnormal_blood_homeostasis0.57193059
141MP0002837_dystrophic_cardiac_calcinosis0.56982443
142MP0001968_abnormal_touch/_nociception0.56205450
143MP0009672_abnormal_birth_weight0.55482846
144MP0005376_homeostasis/metabolism_phenot0.54445193
145MP0004883_abnormal_blood_vessel0.54397157
146MP0005666_abnormal_adipose_tissue0.53357387
147MP0004264_abnormal_extraembryonic_tissu0.52500421
148MP0000579_abnormal_nail_morphology0.52014222
149MP0005334_abnormal_fat_pad0.51400580
150MP0008874_decreased_physiological_sensi0.48125101
151MP0000538_abnormal_urinary_bladder0.47793478
152MP0004859_abnormal_synaptic_plasticity0.47665340
153MP0001915_intracranial_hemorrhage0.47320224
154MP0003123_paternal_imprinting0.44780850
155MP0008872_abnormal_physiological_respon0.44689802
156MP0004270_analgesia0.43982587
157MP0005448_abnormal_energy_balance0.43105336
158MP0002736_abnormal_nociception_after0.42118928
159MP0003699_abnormal_female_reproductive0.41017626
160MP0001177_atelectasis0.40540732
161MP0003632_abnormal_nervous_system0.39741568
162MP0003638_abnormal_response/metabolism_0.39539278
163MP0003953_abnormal_hormone_level0.39409101
164MP0005670_abnormal_white_adipose0.38661825
165MP0006138_congestive_heart_failure0.37993479
166MP0004272_abnormal_basement_membrane0.37618932
167MP0005197_abnormal_uvea_morphology0.36685151
168MP0009765_abnormal_xenobiotic_induced0.36565624
169MP0000427_abnormal_hair_cycle0.36481676
170MP0000230_abnormal_systemic_arterial0.36125269
171MP0001340_abnormal_eyelid_morphology0.35343878
172MP0005266_abnormal_metabolism0.35077915
173MP0002295_abnormal_pulmonary_circulatio0.34218212
174MP0003633_abnormal_nervous_system0.33876399
175MP0001440_abnormal_grooming_behavior0.33416765

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.26724461
2Intrahepatic cholestasis (HP:0001406)6.68053397
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.04471259
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.89351942
5Xanthomatosis (HP:0000991)5.83169937
6Prolonged partial thromboplastin time (HP:0003645)5.67224594
7Hypobetalipoproteinemia (HP:0003563)5.59545446
8Complement deficiency (HP:0004431)5.38974798
9Hyperglycinemia (HP:0002154)4.49472045
10Epidermoid cyst (HP:0200040)4.48838952
11Hypolipoproteinemia (HP:0010981)4.46749257
12Hyperlipoproteinemia (HP:0010980)4.46729859
13Pancreatic fibrosis (HP:0100732)4.23684531
14Pancreatic cysts (HP:0001737)4.21505288
15Hypoalphalipoproteinemia (HP:0003233)4.14635439
16Abnormality of the common coagulation pathway (HP:0010990)4.14375374
17Joint hemorrhage (HP:0005261)4.02049825
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95302323
19Hyperammonemia (HP:0001987)3.94031536
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.92248625
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.87388274
22True hermaphroditism (HP:0010459)3.86335039
23Abnormality of midbrain morphology (HP:0002418)3.83209747
24Molar tooth sign on MRI (HP:0002419)3.83209747
25Abnormality of complement system (HP:0005339)3.81210204
26Hyperglycinuria (HP:0003108)3.79981675
27Abnormality of serine family amino acid metabolism (HP:0010894)3.70798323
28Abnormality of glycine metabolism (HP:0010895)3.70798323
29Abnormality of the renal cortex (HP:0011035)3.66739861
30Ketosis (HP:0001946)3.65052215
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.61801654
32Fat malabsorption (HP:0002630)3.56595313
33Hypochromic microcytic anemia (HP:0004840)3.55596694
34Nephronophthisis (HP:0000090)3.54622522
35Abnormality of methionine metabolism (HP:0010901)3.53616378
36Abnormality of the renal medulla (HP:0100957)3.42893114
37Hepatocellular carcinoma (HP:0001402)3.42458329
38Tubular atrophy (HP:0000092)3.41174709
39Spontaneous abortion (HP:0005268)3.40069851
40Abnormality of the intrinsic pathway (HP:0010989)3.32446155
41Chronic hepatic failure (HP:0100626)3.21712350
42Medial flaring of the eyebrow (HP:0010747)3.20912919
43Conjugated hyperbilirubinemia (HP:0002908)3.16644760
44Myocardial infarction (HP:0001658)3.15302714
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.06678384
46Hypercholesterolemia (HP:0003124)3.04168209
47Hypothermia (HP:0002045)2.97466750
48Abnormality of pyrimidine metabolism (HP:0004353)2.97337867
49Acanthocytosis (HP:0001927)2.93761579
50Hypoglycemic coma (HP:0001325)2.93306145
51Sensorimotor neuropathy (HP:0007141)2.88679093
52Type II lissencephaly (HP:0007260)2.87019285
53Skin nodule (HP:0200036)2.83844272
54Gout (HP:0001997)2.82135186
55Abnormality of serum amino acid levels (HP:0003112)2.80362754
56Large for gestational age (HP:0001520)2.72716714
57Keratoconus (HP:0000563)2.67958793
58Increased corneal curvature (HP:0100692)2.67958793
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.66806547
60Gait imbalance (HP:0002141)2.66460720
61Abnormality of nucleobase metabolism (HP:0010932)2.65477297
62Ketoacidosis (HP:0001993)2.65100272
63Systemic lupus erythematosus (HP:0002725)2.64555188
64Hyperbilirubinemia (HP:0002904)2.59582628
65Congenital primary aphakia (HP:0007707)2.57482425
66Gaze-evoked nystagmus (HP:0000640)2.50460340
67Delayed CNS myelination (HP:0002188)2.50113613
68Abnormality of purine metabolism (HP:0004352)2.49547011
69Cystic liver disease (HP:0006706)2.48128591
70Febrile seizures (HP:0002373)2.47059111
71Glomerulonephritis (HP:0000099)2.45810785
72Abnormal ciliary motility (HP:0012262)2.45801863
73Neuroendocrine neoplasm (HP:0100634)2.45493515
74Spastic diplegia (HP:0001264)2.45139323
75Status epilepticus (HP:0002133)2.43261051
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.42087408
77Neonatal onset (HP:0003623)2.41457044
78Esophageal varix (HP:0002040)2.40052022
79Nephrogenic diabetes insipidus (HP:0009806)2.39507176
80Furrowed tongue (HP:0000221)2.39046865
81Cholelithiasis (HP:0001081)2.38070730
82Congenital sensorineural hearing impairment (HP:0008527)2.37476889
83Genital tract atresia (HP:0001827)2.36861574
84Renal cortical cysts (HP:0000803)2.36488824
85Steatorrhea (HP:0002570)2.36129612
86Abnormal respiratory motile cilium physiology (HP:0012261)2.35565212
87Congenital hepatic fibrosis (HP:0002612)2.33592852
88Abnormal gallbladder morphology (HP:0012437)2.33112589
89Abnormal drinking behavior (HP:0030082)2.30672467
90Polydipsia (HP:0001959)2.30672467
91Occipital encephalocele (HP:0002085)2.28854759
92Rhinitis (HP:0012384)2.28421127
93Poikilocytosis (HP:0004447)2.27733781
94Cerebellar dysplasia (HP:0007033)2.26600931
95Chorioretinal atrophy (HP:0000533)2.25126267
96Vaginal atresia (HP:0000148)2.24884126
97Dynein arm defect of respiratory motile cilia (HP:0012255)2.24452723
98Absent/shortened dynein arms (HP:0200106)2.24452723
99Malnutrition (HP:0004395)2.21818217
100Hyperglycemia (HP:0003074)2.21172188
101Abnormality of the ischium (HP:0003174)2.20205809
102Broad-based gait (HP:0002136)2.19707923
103Confusion (HP:0001289)2.18843551
104Postaxial hand polydactyly (HP:0001162)2.17995888
105Mitral stenosis (HP:0001718)2.16098444
106Cholecystitis (HP:0001082)2.15077802
107Abnormal gallbladder physiology (HP:0012438)2.15077802
108Absent speech (HP:0001344)2.14801503
109Postaxial foot polydactyly (HP:0001830)2.14096744
110Abnormality of fatty-acid metabolism (HP:0004359)2.12440739
111Intestinal atresia (HP:0011100)2.10154781
112Widely spaced teeth (HP:0000687)2.10146047
113Sclerocornea (HP:0000647)2.09545177
114Irritability (HP:0000737)2.08972044
115Congenital stationary night blindness (HP:0007642)2.08591374
116Short tibia (HP:0005736)2.08566068
117Hypoplastic labia majora (HP:0000059)2.08490926
118Tubulointerstitial abnormality (HP:0001969)2.08190330
119Vascular calcification (HP:0004934)2.07413892
120Metabolic acidosis (HP:0001942)2.04049073
121Lethargy (HP:0001254)2.00995321
122Abnormal biliary tract physiology (HP:0012439)2.00591208
123Bile duct proliferation (HP:0001408)2.00591208
124Poor coordination (HP:0002370)2.00455558
125Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99167104
126Bifid tongue (HP:0010297)1.98848269
127Tubulointerstitial nephritis (HP:0001970)1.97617229
128Cardiovascular calcification (HP:0011915)1.97183620
129Thyroid-stimulating hormone excess (HP:0002925)1.97174704
130Abnormality of the Achilles tendon (HP:0005109)1.96976120
131Global brain atrophy (HP:0002283)1.96023799
132Hyperventilation (HP:0002883)1.95129685
133Volvulus (HP:0002580)1.93817290
134Polyuria (HP:0000103)1.93577188
135Abnormal respiratory motile cilium morphology (HP:0005938)1.91025734
136Abnormal respiratory epithelium morphology (HP:0012253)1.91025734
137Hypoplastic ischia (HP:0003175)1.89089558
138Abnormality of the gallbladder (HP:0005264)1.87931483
139Recurrent gram-negative bacterial infections (HP:0005420)1.87470012
140Abnormality of the labia majora (HP:0012881)1.86786047
141Amyloidosis (HP:0011034)1.86148140
142Attenuation of retinal blood vessels (HP:0007843)1.86081997
143Abnormal pancreas size (HP:0012094)1.84724997
144Hemorrhage of the eye (HP:0011885)1.84692512
145Hypoglycemic seizures (HP:0002173)1.83335763
146Tubulointerstitial fibrosis (HP:0005576)1.83273226
147Male pseudohermaphroditism (HP:0000037)1.83160602
148Nephritis (HP:0000123)1.82774295
149Narrow forehead (HP:0000341)1.82755040
150Increased purine levels (HP:0004368)1.81296046
151Hyperuricemia (HP:0002149)1.81296046
152Genetic anticipation (HP:0003743)1.78702766
153Fair hair (HP:0002286)1.78590192
154Rickets (HP:0002748)1.78468706
155Enlarged kidneys (HP:0000105)1.78447059
156Drooling (HP:0002307)1.77632572
157Abnormality of the lower motor neuron (HP:0002366)1.77592996
158Anencephaly (HP:0002323)1.77586680
159Upper motor neuron abnormality (HP:0002127)1.77525650
160Reticulocytosis (HP:0001923)1.75987942
161Short foot (HP:0001773)1.75378504
162Turricephaly (HP:0000262)1.72659244
163Abnormality of proline metabolism (HP:0010907)1.72602305
164Hydroxyprolinuria (HP:0003080)1.72602305
165Abolished electroretinogram (ERG) (HP:0000550)1.72006809
166Atonic seizures (HP:0010819)1.71853237
167Generalized hypopigmentation of hair (HP:0011358)1.71753074
168Inability to walk (HP:0002540)1.71032407
169Oculomotor apraxia (HP:0000657)1.70410598
170Abnormal cartilage morphology (HP:0002763)1.69789640
171Anophthalmia (HP:0000528)1.69174565
172Small hand (HP:0200055)1.68561464
173Aplasia/Hypoplasia of the lens (HP:0008063)1.67846728
174Lissencephaly (HP:0001339)1.67202888
175Blue irides (HP:0000635)1.67169751
176Hemiparesis (HP:0001269)1.67167123
177Preaxial foot polydactyly (HP:0001841)1.67019089
178Median cleft lip (HP:0000161)1.66835555
179Pheochromocytoma (HP:0002666)1.66525052
180Labial hypoplasia (HP:0000066)1.66346581
181Hyperinsulinemic hypoglycemia (HP:0000825)1.65269907
182Termporal pattern (HP:0011008)1.64358507
183Insidious onset (HP:0003587)1.64358507
184Cortical dysplasia (HP:0002539)1.64320595
185Thrombophlebitis (HP:0004418)1.63708470
186Back pain (HP:0003418)1.63519137
187Progressive inability to walk (HP:0002505)1.63271132
188Progressive cerebellar ataxia (HP:0002073)1.63204248
189Optic nerve hypoplasia (HP:0000609)1.63003460
190Tetraplegia (HP:0002445)1.61656261
191Cerebral edema (HP:0002181)1.61607984
192Abnormality of macular pigmentation (HP:0008002)1.61586451
193Abnormality of dicarboxylic acid metabolism (HP:0010995)1.60657779
194Dicarboxylic aciduria (HP:0003215)1.60657779
195Neoplasm of the peripheral nervous system (HP:0100007)1.60475989
196Short hallux (HP:0010109)1.58459152
197Preaxial hand polydactyly (HP:0001177)1.57387979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.59182432
2LATS24.22184082
3BMPR1B3.95007177
4ERBB43.00276603
5STK38L2.97307479
6ACVR1B2.63165176
7MAP2K42.59428283
8TNIK2.32133589
9MAP3K42.29440939
10FRK2.28627160
11KSR22.10406268
12SIK12.09210431
13MST1R2.06697095
14STK392.01969920
15ADRBK22.01092440
16DAPK21.99730936
17EPHA41.92996556
18ABL21.90257894
19TRIM281.89891666
20BCKDK1.87543458
21MAP3K91.78726841
22PINK11.76731354
23CAMK1D1.74648383
24MAP4K21.73836908
25STK31.66480601
26TAOK31.65925054
27BCR1.59420269
28NTRK11.57016768
29STK381.54230368
30GRK11.46418518
31NTRK31.43910780
32WNK41.43052860
33PKN21.42998213
34EIF2AK31.39842948
35MAPK131.38088764
36FGFR41.36574017
37RET1.34548950
38ERBB31.33771060
39NEK91.33010631
40MAP3K121.32958960
41MARK11.29324709
42MKNK21.26752549
43CAMK1G1.26083030
44TRIB31.25776150
45INSRR1.25593856
46OXSR11.24787589
47PAK61.24685796
48PRKCE1.23217866
49SGK21.22203975
50MAP3K61.19592350
51PDGFRA1.16978483
52MET1.14284783
53MAP3K21.13904714
54KSR11.11433320
55MYLK1.10953252
56FGFR21.09340983
57SGK31.08872002
58ADRBK11.00748891
59AKT31.00650646
60GRK50.99194800
61MAPK150.97554357
62STK160.97193271
63EPHA30.96632416
64MAP2K70.96468091
65TGFBR20.94554705
66CSNK1G20.91123517
67ERN10.90745161
68MAPK110.90275471
69IRAK10.89484899
70RIPK10.88628303
71BRSK20.88357306
72CSNK1G10.86943387
73PRKAA20.86679609
74PTK20.85140631
75MAP2K10.84836827
76CDK120.83850615
77DMPK0.83678052
78TIE10.83160540
79SGK2230.82072739
80SGK4940.82072739
81RAF10.81997486
82ERBB20.81759252
83MST40.80615006
84PRKAA10.80363398
85TYRO30.79618728
86PLK20.78659849
87CAMKK10.78040151
88NUAK10.76580096
89SCYL20.75341851
90TRPM70.74398144
91TGFBR10.74281533
92FER0.74193157
93EIF2AK10.73847894
94WNK30.73521436
95NLK0.72421975
96PIK3CG0.72212309
97CAMKK20.71662119
98PAK30.71492842
99PHKG10.71196491
100PHKG20.71196491
101STK240.70897303
102ZAK0.70169024
103PRKCZ0.69319071
104CDK60.68801683
105ROCK10.68328726
106WNK10.68112743
107PDPK10.66207289
108MINK10.65287081
109NEK10.62010818
110JAK20.61561929
111DDR20.60448973
112MELK0.60230153
113BMX0.60183642
114PRKCG0.59667064
115CDK30.57402924
116MUSK0.57325593
117MAP3K50.56381158
118PRKG10.53882330
119WEE10.53861304
120TAOK10.52732592
121PDGFRB0.51338993
122PTK60.51262292
123CASK0.50881545
124PLK30.50771867
125OBSCN0.48072027
126FLT30.47600597
127GSK3A0.45963355
128EPHB20.45257623
129CSNK1G30.43022332
130DYRK1A0.42267743
131NTRK20.41948860
132PTK2B0.41021539
133MTOR0.40014799
134PDK30.39606841
135PDK40.39606841
136FGFR10.39376977
137PRKACB0.39362479
138SGK10.39264296
139CSNK1E0.39165590
140CAMK2D0.39019691
141RPS6KA30.38458376
142IGF1R0.37628453
143LMTK20.37628414
144PIK3CA0.37541606
145STK110.37261295
146PRKACG0.36695212
147MOS0.36463029
148YES10.36061643
149MAPK100.35962951
150CSNK1A1L0.35394402
151PRKACA0.34839867
152MKNK10.34301618
153FGFR30.34064241
154PDK10.33563343
155PNCK0.32427269
156BRAF0.32074038
157CAMK2A0.30684496

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.58647893
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.33599082
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38228969
4Arginine biosynthesis_Homo sapiens_hsa002203.25405091
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15687530
6Complement and coagulation cascades_Homo sapiens_hsa046102.86555913
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55647916
8Tryptophan metabolism_Homo sapiens_hsa003802.51777103
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50947647
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41071073
11Fatty acid degradation_Homo sapiens_hsa000712.27007846
12Butanoate metabolism_Homo sapiens_hsa006502.19801112
13Protein export_Homo sapiens_hsa030602.13781971
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11468254
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.06924549
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00644293
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85539943
18PPAR signaling pathway_Homo sapiens_hsa033201.82733668
19Histidine metabolism_Homo sapiens_hsa003401.77731103
20Peroxisome_Homo sapiens_hsa041461.75846477
21Bile secretion_Homo sapiens_hsa049761.74765257
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74538486
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74345930
24Propanoate metabolism_Homo sapiens_hsa006401.71488110
25Phototransduction_Homo sapiens_hsa047441.69148330
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68953246
27Fatty acid metabolism_Homo sapiens_hsa012121.63840741
28Staphylococcus aureus infection_Homo sapiens_hsa051501.61852787
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57422628
30Vitamin B6 metabolism_Homo sapiens_hsa007501.56040118
31Phenylalanine metabolism_Homo sapiens_hsa003601.55932982
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.54074929
33Chemical carcinogenesis_Homo sapiens_hsa052041.53353132
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50652365
35beta-Alanine metabolism_Homo sapiens_hsa004101.50257220
36Tyrosine metabolism_Homo sapiens_hsa003501.46295471
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44766527
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44518892
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42198038
40Caffeine metabolism_Homo sapiens_hsa002321.40947335
41Retinol metabolism_Homo sapiens_hsa008301.38251743
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33897327
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.32752570
44Insulin secretion_Homo sapiens_hsa049111.30900084
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30213188
46Ether lipid metabolism_Homo sapiens_hsa005651.30141396
47Mineral absorption_Homo sapiens_hsa049781.27347494
48Pyruvate metabolism_Homo sapiens_hsa006201.26972107
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26501401
50Morphine addiction_Homo sapiens_hsa050321.26097663
51Selenocompound metabolism_Homo sapiens_hsa004501.23768114
52Regulation of autophagy_Homo sapiens_hsa041401.22553165
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21542059
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.19939121
55Circadian entrainment_Homo sapiens_hsa047131.19058353
56Taste transduction_Homo sapiens_hsa047421.18702877
57Basal transcription factors_Homo sapiens_hsa030221.16710577
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14209412
59Starch and sucrose metabolism_Homo sapiens_hsa005001.13294603
60Biosynthesis of amino acids_Homo sapiens_hsa012301.10180056
61TGF-beta signaling pathway_Homo sapiens_hsa043501.07783902
62Hedgehog signaling pathway_Homo sapiens_hsa043401.04477942
63Glutamatergic synapse_Homo sapiens_hsa047241.03197018
64Serotonergic synapse_Homo sapiens_hsa047261.01658872
65ABC transporters_Homo sapiens_hsa020101.01046602
66Sulfur metabolism_Homo sapiens_hsa009200.99598887
67Sphingolipid metabolism_Homo sapiens_hsa006000.98296223
68Carbon metabolism_Homo sapiens_hsa012000.95366470
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95177474
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94973276
71Lysine degradation_Homo sapiens_hsa003100.92503344
72Oxidative phosphorylation_Homo sapiens_hsa001900.91228324
73Fat digestion and absorption_Homo sapiens_hsa049750.89132383
74Dopaminergic synapse_Homo sapiens_hsa047280.89124526
75Protein digestion and absorption_Homo sapiens_hsa049740.87737526
76Fanconi anemia pathway_Homo sapiens_hsa034600.86757830
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.85910142
78Vitamin digestion and absorption_Homo sapiens_hsa049770.84380862
79Arginine and proline metabolism_Homo sapiens_hsa003300.82846831
80Olfactory transduction_Homo sapiens_hsa047400.81099900
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79840846
82Salivary secretion_Homo sapiens_hsa049700.79797558
83Steroid biosynthesis_Homo sapiens_hsa001000.77802851
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77773599
85Fatty acid biosynthesis_Homo sapiens_hsa000610.77018631
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.72888057
87Folate biosynthesis_Homo sapiens_hsa007900.71715285
88Arachidonic acid metabolism_Homo sapiens_hsa005900.69137282
89ECM-receptor interaction_Homo sapiens_hsa045120.68416349
90Glycerolipid metabolism_Homo sapiens_hsa005610.68066204
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.64910692
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64857426
93Long-term depression_Homo sapiens_hsa047300.64558914
94Fatty acid elongation_Homo sapiens_hsa000620.64291664
95Hippo signaling pathway_Homo sapiens_hsa043900.62968437
96Cardiac muscle contraction_Homo sapiens_hsa042600.62181238
97Axon guidance_Homo sapiens_hsa043600.61262802
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56669217
99Collecting duct acid secretion_Homo sapiens_hsa049660.55706855
100Calcium signaling pathway_Homo sapiens_hsa040200.55403001
101Non-homologous end-joining_Homo sapiens_hsa034500.53254447
102Pancreatic secretion_Homo sapiens_hsa049720.52172678
103cAMP signaling pathway_Homo sapiens_hsa040240.50814105
104Cocaine addiction_Homo sapiens_hsa050300.50519736
105Prion diseases_Homo sapiens_hsa050200.49947579
106Cholinergic synapse_Homo sapiens_hsa047250.49764365
107Tight junction_Homo sapiens_hsa045300.49314799
108Dilated cardiomyopathy_Homo sapiens_hsa054140.47559888
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47287860
110Basal cell carcinoma_Homo sapiens_hsa052170.44824816
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42089116
112Dorso-ventral axis formation_Homo sapiens_hsa043200.41968949
113Glucagon signaling pathway_Homo sapiens_hsa049220.41043120
114Pentose phosphate pathway_Homo sapiens_hsa000300.39927540
115Glutathione metabolism_Homo sapiens_hsa004800.35774266
116Insulin resistance_Homo sapiens_hsa049310.35146064
117Sulfur relay system_Homo sapiens_hsa041220.34452828
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30817386
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.28501680
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28382915
121One carbon pool by folate_Homo sapiens_hsa006700.27908556
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.27888125
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26710465
124Metabolic pathways_Homo sapiens_hsa011000.25186889
125Ovarian steroidogenesis_Homo sapiens_hsa049130.24171308
126AMPK signaling pathway_Homo sapiens_hsa041520.18689587
127Insulin signaling pathway_Homo sapiens_hsa049100.16698903
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15306101
129Circadian rhythm_Homo sapiens_hsa047100.13056001
130Thyroid hormone synthesis_Homo sapiens_hsa049180.11483595
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.09731422
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07632106
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.06145460
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05134502
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.04763012
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04398511
137Synaptic vesicle cycle_Homo sapiens_hsa047210.03932741
138Type II diabetes mellitus_Homo sapiens_hsa049300.03868465
139Glioma_Homo sapiens_hsa052140.03754237
140GABAergic synapse_Homo sapiens_hsa047270.03107265
141Estrogen signaling pathway_Homo sapiens_hsa049150.02635419
142mTOR signaling pathway_Homo sapiens_hsa041500.02243597
143Amphetamine addiction_Homo sapiens_hsa050310.02233174
144Linoleic acid metabolism_Homo sapiens_hsa005910.01632937
145Amoebiasis_Homo sapiens_hsa051460.00889288
146Renin secretion_Homo sapiens_hsa04924-0.0135458
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0120154
148Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0088087
149Nicotine addiction_Homo sapiens_hsa05033-0.0069132
150Bladder cancer_Homo sapiens_hsa05219-0.0052199

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