

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.42865219 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.21378573 |
| 3 | locomotory exploration behavior (GO:0035641) | 4.99194684 |
| 4 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.93894249 |
| 5 | vocalization behavior (GO:0071625) | 4.61670636 |
| 6 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.61467544 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.54847077 |
| 8 | layer formation in cerebral cortex (GO:0021819) | 4.52713152 |
| 9 | neuron cell-cell adhesion (GO:0007158) | 4.38658737 |
| 10 | glutamate secretion (GO:0014047) | 4.35855404 |
| 11 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.32855963 |
| 12 | synaptic vesicle exocytosis (GO:0016079) | 4.32018725 |
| 13 | dendritic spine morphogenesis (GO:0060997) | 4.23131306 |
| 14 | protein localization to synapse (GO:0035418) | 4.21334572 |
| 15 | regulation of synapse structural plasticity (GO:0051823) | 4.10367043 |
| 16 | cerebellar granule cell differentiation (GO:0021707) | 4.07425743 |
| 17 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.04593978 |
| 18 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.91191609 |
| 19 | regulation of synaptic vesicle transport (GO:1902803) | 3.91114906 |
| 20 | exploration behavior (GO:0035640) | 3.87929340 |
| 21 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.79307066 |
| 22 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.78634389 |
| 23 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.77947167 |
| 24 | neuronal ion channel clustering (GO:0045161) | 3.74465781 |
| 25 | neuron recognition (GO:0008038) | 3.71295127 |
| 26 | dendrite morphogenesis (GO:0048813) | 3.70694610 |
| 27 | neurotransmitter secretion (GO:0007269) | 3.67271240 |
| 28 | cell migration in hindbrain (GO:0021535) | 3.66876818 |
| 29 | auditory behavior (GO:0031223) | 3.62728016 |
| 30 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.61342786 |
| 31 | gamma-aminobutyric acid transport (GO:0015812) | 3.55557560 |
| 32 | neuronal action potential propagation (GO:0019227) | 3.55205003 |
| 33 | axonal fasciculation (GO:0007413) | 3.53448865 |
| 34 | synaptic transmission, glutamatergic (GO:0035249) | 3.47268176 |
| 35 | glycine transport (GO:0015816) | 3.44594179 |
| 36 | regulation of synapse maturation (GO:0090128) | 3.33517362 |
| 37 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.32162660 |
| 38 | response to auditory stimulus (GO:0010996) | 3.28669714 |
| 39 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.25279848 |
| 40 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.25167467 |
| 41 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.24493904 |
| 42 | sodium ion export (GO:0071436) | 3.24291116 |
| 43 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.24255389 |
| 44 | response to pheromone (GO:0019236) | 3.23816200 |
| 45 | synaptic vesicle endocytosis (GO:0048488) | 3.21833773 |
| 46 | proline transport (GO:0015824) | 3.20283498 |
| 47 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.20165215 |
| 48 | cellular potassium ion homeostasis (GO:0030007) | 3.19336914 |
| 49 | activation of protein kinase A activity (GO:0034199) | 3.17143493 |
| 50 | glutamate receptor signaling pathway (GO:0007215) | 3.16942269 |
| 51 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.15893176 |
| 52 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.15835881 |
| 53 | neuron-neuron synaptic transmission (GO:0007270) | 3.14947193 |
| 54 | long-term memory (GO:0007616) | 3.13692409 |
| 55 | neuromuscular process controlling balance (GO:0050885) | 3.13409031 |
| 56 | amino acid import (GO:0043090) | 3.12579507 |
| 57 | L-amino acid import (GO:0043092) | 3.12329132 |
| 58 | membrane depolarization during action potential (GO:0086010) | 3.09577129 |
| 59 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.08748605 |
| 60 | positive regulation of synapse maturation (GO:0090129) | 3.05047731 |
| 61 | axon extension (GO:0048675) | 3.01609696 |
| 62 | negative regulation of catenin import into nucleus (GO:0035414) | 3.01501553 |
| 63 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.01434031 |
| 64 | cell-cell junction maintenance (GO:0045217) | 3.01354431 |
| 65 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.00928882 |
| 66 | positive regulation of membrane potential (GO:0045838) | 2.99995456 |
| 67 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.99681270 |
| 68 | transmission of nerve impulse (GO:0019226) | 2.98665438 |
| 69 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.98411492 |
| 70 | neurotransmitter transport (GO:0006836) | 2.98326793 |
| 71 | postsynaptic membrane organization (GO:0001941) | 2.97208337 |
| 72 | prepulse inhibition (GO:0060134) | 2.95361402 |
| 73 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.95340091 |
| 74 | regulation of neurotransmitter secretion (GO:0046928) | 2.93668079 |
| 75 | calcium ion-dependent exocytosis (GO:0017156) | 2.92680176 |
| 76 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.91439079 |
| 77 | cerebellar Purkinje cell layer development (GO:0021680) | 2.91183806 |
| 78 | innervation (GO:0060384) | 2.90166518 |
| 79 | regulation of postsynaptic membrane potential (GO:0060078) | 2.89099275 |
| 80 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.88781659 |
| 81 | mitochondrion transport along microtubule (GO:0047497) | 2.88493319 |
| 82 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.88493319 |
| 83 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.88415197 |
| 84 | protein targeting to plasma membrane (GO:0072661) | 2.88165429 |
| 85 | cell communication by electrical coupling (GO:0010644) | 2.86275660 |
| 86 | adult walking behavior (GO:0007628) | 2.85648889 |
| 87 | regulation of synaptic plasticity (GO:0048167) | 2.85508482 |
| 88 | regulation of ARF protein signal transduction (GO:0032012) | 2.85480975 |
| 89 | negative regulation of microtubule polymerization (GO:0031115) | 2.85173646 |
| 90 | neuron projection extension (GO:1990138) | 2.85170024 |
| 91 | mechanosensory behavior (GO:0007638) | 2.84612436 |
| 92 | clathrin coat assembly (GO:0048268) | 2.84313200 |
| 93 | mating behavior (GO:0007617) | 2.83833513 |
| 94 | protein localization to endosome (GO:0036010) | 2.83061386 |
| 95 | establishment of mitochondrion localization (GO:0051654) | 2.82664597 |
| 96 | dopamine receptor signaling pathway (GO:0007212) | 2.82437177 |
| 97 | positive regulation of dendritic spine development (GO:0060999) | 2.82346472 |
| 98 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.81913444 |
| 99 | axon cargo transport (GO:0008088) | 2.80910243 |
| 100 | regulation of vesicle fusion (GO:0031338) | 2.80810456 |
| 101 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.80710113 |
| 102 | synapse assembly (GO:0007416) | 2.80613130 |
| 103 | membrane depolarization (GO:0051899) | 2.80113717 |
| 104 | membrane hyperpolarization (GO:0060081) | 2.79867947 |
| 105 | establishment of nucleus localization (GO:0040023) | 2.78390929 |
| 106 | central nervous system myelination (GO:0022010) | 2.76307286 |
| 107 | axon ensheathment in central nervous system (GO:0032291) | 2.76307286 |
| 108 | cellular response to monoamine stimulus (GO:0071868) | 2.75843108 |
| 109 | cellular response to catecholamine stimulus (GO:0071870) | 2.75843108 |
| 110 | positive regulation of dendrite development (GO:1900006) | 2.74023439 |
| 111 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.73689950 |
| 112 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.73689950 |
| 113 | presynaptic membrane organization (GO:0097090) | 2.73687244 |
| 114 | potassium ion homeostasis (GO:0055075) | 2.71319698 |
| 115 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.71238282 |
| 116 | dendritic spine organization (GO:0097061) | 2.71213959 |
| 117 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.70996111 |
| 118 | organelle transport along microtubule (GO:0072384) | 2.70664463 |
| 119 | regulation of neurotransmitter levels (GO:0001505) | 2.70442603 |
| 120 | synapse organization (GO:0050808) | 2.70131231 |
| 121 | regulation of neurotransmitter transport (GO:0051588) | 2.69149268 |
| 122 | regulation of dendritic spine development (GO:0060998) | 2.68512556 |
| 123 | vesicle transport along microtubule (GO:0047496) | 2.68329885 |
| 124 | learning (GO:0007612) | 2.66861890 |
| 125 | presynaptic membrane assembly (GO:0097105) | 2.64603992 |
| 126 | regulation of ARF GTPase activity (GO:0032312) | 2.62616301 |
| 127 | positive regulation of axon extension (GO:0045773) | 2.60403668 |
| 128 | semaphorin-plexin signaling pathway (GO:0071526) | 2.55614787 |
| 129 | protein retention in ER lumen (GO:0006621) | 2.54703189 |
| 130 | neuromuscular process (GO:0050905) | 2.52290640 |
| 131 | regulation of early endosome to late endosome transport (GO:2000641) | 2.51789005 |
| 132 | response to acidic pH (GO:0010447) | 2.50082044 |
| 133 | neuromuscular synaptic transmission (GO:0007274) | 2.43292030 |
| 134 | regulation of respiratory system process (GO:0044065) | 2.43011843 |
| 135 | response to parathyroid hormone (GO:0071107) | 2.41072609 |
| 136 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.40815381 |
| 137 | regulation of synaptic transmission (GO:0050804) | 2.39866559 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.85308525 |
| 2 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 3.20060568 |
| 3 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.08087415 |
| 4 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.82232249 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.76337423 |
| 6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.74934360 |
| 7 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.64861197 |
| 8 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.55721395 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.54173459 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.54173459 |
| 11 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.50373017 |
| 12 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.48441494 |
| 13 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.47434697 |
| 14 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.46068142 |
| 15 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.44588948 |
| 16 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.44296624 |
| 17 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.41239122 |
| 18 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.37718954 |
| 19 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.30538208 |
| 20 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.27997942 |
| 21 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.26764873 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.24761114 |
| 23 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.23366713 |
| 24 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.13104874 |
| 25 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.11059399 |
| 26 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.08820711 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.08577707 |
| 28 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.01926095 |
| 29 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.01235801 |
| 30 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.95730014 |
| 31 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.92231881 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.88653217 |
| 33 | * CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.83108069 |
| 34 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.78364397 |
| 35 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.66047701 |
| 36 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.64645762 |
| 37 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.59463258 |
| 38 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.54927212 |
| 39 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.51830426 |
| 40 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.48948878 |
| 41 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.48407614 |
| 42 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.47910643 |
| 43 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.46468569 |
| 44 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.46432038 |
| 45 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.46362870 |
| 46 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.44283540 |
| 47 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.44047478 |
| 48 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.43288081 |
| 49 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.42953937 |
| 50 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.42396802 |
| 51 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.39173200 |
| 52 | * P68_20966046_ChIP-Seq_HELA_Human | 1.39012054 |
| 53 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.38735152 |
| 54 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.38304808 |
| 55 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.37662860 |
| 56 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.36316436 |
| 57 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.35815804 |
| 58 | KDM2B_26808549_Chip-Seq_K562_Human | 1.31234158 |
| 59 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.29728654 |
| 60 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.28574596 |
| 61 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.28182616 |
| 62 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.27817828 |
| 63 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.27075784 |
| 64 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.26897281 |
| 65 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.26335572 |
| 66 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.25830499 |
| 67 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.25430408 |
| 68 | * CREB1_26743006_Chip-Seq_LNCaP_Human | 1.25120138 |
| 69 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.25085524 |
| 70 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.24123081 |
| 71 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.23706649 |
| 72 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.23355702 |
| 73 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.23354436 |
| 74 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.22364388 |
| 75 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.17628350 |
| 76 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.16935141 |
| 77 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.16177151 |
| 78 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.15203222 |
| 79 | AR_19668381_ChIP-Seq_PC3_Human | 1.14752212 |
| 80 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.14594564 |
| 81 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.14088677 |
| 82 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.14029359 |
| 83 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.13922896 |
| 84 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.12287895 |
| 85 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.12166209 |
| 86 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.11782051 |
| 87 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.11328682 |
| 88 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.10585393 |
| 89 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.10473147 |
| 90 | * CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.10290720 |
| 91 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.08987994 |
| 92 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.07720391 |
| 93 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.07305113 |
| 94 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.06660895 |
| 95 | * MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.05792038 |
| 96 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.05674095 |
| 97 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.04995514 |
| 98 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.04681254 |
| 99 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.04546689 |
| 100 | * OCT4_19829295_ChIP-Seq_ESCs_Human | 1.03531060 |
| 101 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.03294948 |
| 102 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.02626945 |
| 103 | * TP53_22127205_ChIP-Seq_IMR90_Human | 1.02592650 |
| 104 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.02550469 |
| 105 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.02023131 |
| 106 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.01702319 |
| 107 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.01222194 |
| 108 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.00898160 |
| 109 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.00819944 |
| 110 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.00569785 |
| 111 | * STAT3_23295773_ChIP-Seq_U87_Human | 0.99290592 |
| 112 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.98871416 |
| 113 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.98445331 |
| 114 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.98162399 |
| 115 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.97694378 |
| 116 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.97383675 |
| 117 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.96398950 |
| 118 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.96019792 |
| 119 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.95861975 |
| 120 | AR_25329375_ChIP-Seq_VCAP_Human | 0.95469353 |
| 121 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95120747 |
| 122 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.94868341 |
| 123 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.94654291 |
| 124 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.94527306 |
| 125 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.93680559 |
| 126 | TCF4_23295773_ChIP-Seq_U87_Human | 0.93509111 |
| 127 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.93146307 |
| 128 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.92686499 |
| 129 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.92679776 |
| 130 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.90167648 |
| 131 | P300_19829295_ChIP-Seq_ESCs_Human | 0.90123282 |
| 132 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.89591507 |
| 133 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.89321950 |
| 134 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89306647 |
| 135 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.89090754 |
| 136 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.88331646 |
| 137 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87905459 |
| 138 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.87255542 |
| 139 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.86989537 |
| 140 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.86591415 |
| 141 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.86481890 |
| 142 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84071600 |
| 143 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.84071600 |
| 144 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.83958192 |
| 145 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.82865375 |
| 146 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.82794233 |
| 147 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.80406701 |
| 148 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.80329740 |
| 149 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.79846586 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.78898115 |
| 2 | MP0003880_abnormal_central_pattern | 4.16508767 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.62249791 |
| 4 | MP0004270_analgesia | 3.61227942 |
| 5 | MP0005423_abnormal_somatic_nervous | 3.09648178 |
| 6 | MP0002063_abnormal_learning/memory/cond | 2.98657088 |
| 7 | MP0009745_abnormal_behavioral_response | 2.75477149 |
| 8 | MP0002064_seizures | 2.69890657 |
| 9 | MP0001968_abnormal_touch/_nociception | 2.66828298 |
| 10 | MP0009046_muscle_twitch | 2.56319086 |
| 11 | MP0003705_abnormal_hypodermis_morpholog | 2.47554326 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.46037218 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.42151057 |
| 14 | MP0001486_abnormal_startle_reflex | 2.41672299 |
| 15 | MP0000778_abnormal_nervous_system | 2.36277977 |
| 16 | MP0002272_abnormal_nervous_system | 2.36013690 |
| 17 | MP0005410_abnormal_fertilization | 2.14068799 |
| 18 | MP0002733_abnormal_thermal_nociception | 2.12745440 |
| 19 | MP0002735_abnormal_chemical_nociception | 2.00487735 |
| 20 | MP0008569_lethality_at_weaning | 1.94130423 |
| 21 | MP0003329_amyloid_beta_deposits | 1.93301074 |
| 22 | MP0001440_abnormal_grooming_behavior | 1.91613787 |
| 23 | MP0002736_abnormal_nociception_after | 1.90291979 |
| 24 | MP0002822_catalepsy | 1.90186653 |
| 25 | MP0001970_abnormal_pain_threshold | 1.89859291 |
| 26 | MP0002184_abnormal_innervation | 1.88933710 |
| 27 | MP0004858_abnormal_nervous_system | 1.88558008 |
| 28 | MP0004811_abnormal_neuron_physiology | 1.86866447 |
| 29 | MP0002067_abnormal_sensory_capabilities | 1.83250201 |
| 30 | MP0000955_abnormal_spinal_cord | 1.82371285 |
| 31 | MP0009780_abnormal_chondrocyte_physiolo | 1.80452992 |
| 32 | MP0000013_abnormal_adipose_tissue | 1.77633317 |
| 33 | MP0006276_abnormal_autonomic_nervous | 1.77228795 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.70763306 |
| 35 | MP0004885_abnormal_endolymph | 1.68162373 |
| 36 | MP0008438_abnormal_cutaneous_collagen | 1.62047543 |
| 37 | MP0004924_abnormal_behavior | 1.58122029 |
| 38 | MP0005386_behavior/neurological_phenoty | 1.58122029 |
| 39 | MP0002882_abnormal_neuron_morphology | 1.55981018 |
| 40 | MP0001529_abnormal_vocalization | 1.54209271 |
| 41 | MP0002909_abnormal_adrenal_gland | 1.51215726 |
| 42 | MP0001958_emphysema | 1.51058791 |
| 43 | MP0000751_myopathy | 1.49092489 |
| 44 | MP0005409_darkened_coat_color | 1.48823048 |
| 45 | MP0001501_abnormal_sleep_pattern | 1.48223989 |
| 46 | MP0002066_abnormal_motor_capabilities/c | 1.41402403 |
| 47 | MP0000920_abnormal_myelination | 1.41327071 |
| 48 | MP0005645_abnormal_hypothalamus_physiol | 1.39679674 |
| 49 | MP0003879_abnormal_hair_cell | 1.39621730 |
| 50 | MP0004742_abnormal_vestibular_system | 1.39612585 |
| 51 | MP0004510_myositis | 1.38855149 |
| 52 | MP0004142_abnormal_muscle_tone | 1.38385088 |
| 53 | MP0001984_abnormal_olfaction | 1.28654532 |
| 54 | MP0003122_maternal_imprinting | 1.27190337 |
| 55 | MP0002152_abnormal_brain_morphology | 1.26157894 |
| 56 | MP0003123_paternal_imprinting | 1.25899138 |
| 57 | MP0001502_abnormal_circadian_rhythm | 1.25184931 |
| 58 | MP0003279_aneurysm | 1.24364913 |
| 59 | MP0003634_abnormal_glial_cell | 1.23692432 |
| 60 | MP0000747_muscle_weakness | 1.23375063 |
| 61 | MP0002249_abnormal_larynx_morphology | 1.22912800 |
| 62 | MP0003633_abnormal_nervous_system | 1.21761071 |
| 63 | MP0004145_abnormal_muscle_electrophysio | 1.21580296 |
| 64 | MP0005646_abnormal_pituitary_gland | 1.20064396 |
| 65 | MP0000569_abnormal_digit_pigmentation | 1.19795781 |
| 66 | MP0008961_abnormal_basal_metabolism | 1.12392795 |
| 67 | MP0003631_nervous_system_phenotype | 1.07198525 |
| 68 | MP0001905_abnormal_dopamine_level | 1.06469751 |
| 69 | MP0002229_neurodegeneration | 1.04846019 |
| 70 | MP0005623_abnormal_meninges_morphology | 1.04513898 |
| 71 | MP0002653_abnormal_ependyma_morphology | 1.03807008 |
| 72 | MP0003698_abnormal_male_reproductive | 0.99980910 |
| 73 | MP0001299_abnormal_eye_distance/ | 0.99398429 |
| 74 | MP0003787_abnormal_imprinting | 0.97140080 |
| 75 | MP0000631_abnormal_neuroendocrine_gland | 0.96925808 |
| 76 | MP0005551_abnormal_eye_electrophysiolog | 0.96850985 |
| 77 | MP0008874_decreased_physiological_sensi | 0.96844048 |
| 78 | MP0000003_abnormal_adipose_tissue | 0.96361314 |
| 79 | MP0000759_abnormal_skeletal_muscle | 0.95104249 |
| 80 | MP0003137_abnormal_impulse_conducting | 0.93716992 |
| 81 | MP0002752_abnormal_somatic_nervous | 0.91651871 |
| 82 | MP0000749_muscle_degeneration | 0.91133983 |
| 83 | MP0002069_abnormal_eating/drinking_beha | 0.89184680 |
| 84 | MP0000678_abnormal_parathyroid_gland | 0.88319362 |
| 85 | MP0005503_abnormal_tendon_morphology | 0.87317556 |
| 86 | MP0002102_abnormal_ear_morphology | 0.87169909 |
| 87 | MP0003283_abnormal_digestive_organ | 0.86005881 |
| 88 | MP0003861_abnormal_nervous_system | 0.85253610 |
| 89 | MP0003690_abnormal_glial_cell | 0.85245330 |
| 90 | MP0003632_abnormal_nervous_system | 0.84733564 |
| 91 | MP0005257_abnormal_intraocular_pressure | 0.84063336 |
| 92 | MP0001849_ear_inflammation | 0.82394771 |
| 93 | MP0002638_abnormal_pupillary_reflex | 0.82047053 |
| 94 | MP0002089_abnormal_postnatal_growth/wei | 0.81057863 |
| 95 | MP0004085_abnormal_heartbeat | 0.80922680 |
| 96 | MP0004087_abnormal_muscle_fiber | 0.80870026 |
| 97 | MP0000733_abnormal_muscle_development | 0.79804722 |
| 98 | MP0009379_abnormal_foot_pigmentation | 0.78816189 |
| 99 | MP0004233_abnormal_muscle_weight | 0.77313219 |
| 100 | MP0003091_abnormal_cell_migration | 0.77260124 |
| 101 | MP0001177_atelectasis | 0.77175315 |
| 102 | MP0005670_abnormal_white_adipose | 0.76858332 |
| 103 | MP0000579_abnormal_nail_morphology | 0.75997229 |
| 104 | MP0001963_abnormal_hearing_physiology | 0.74974563 |
| 105 | MP0002234_abnormal_pharynx_morphology | 0.74790221 |
| 106 | MP0002837_dystrophic_cardiac_calcinosis | 0.74178935 |
| 107 | MP0000604_amyloidosis | 0.73159803 |
| 108 | MP0004130_abnormal_muscle_cell | 0.72864909 |
| 109 | MP0001485_abnormal_pinna_reflex | 0.72094796 |
| 110 | MP0008260_abnormal_autophagy | 0.71535063 |
| 111 | MP0003566_abnormal_cell_adhesion | 0.70695239 |
| 112 | MP0005058_abnormal_lysosome_morphology | 0.69882872 |
| 113 | MP0005499_abnormal_olfactory_system | 0.69182545 |
| 114 | MP0005394_taste/olfaction_phenotype | 0.69182545 |
| 115 | MP0003075_altered_response_to | 0.69167942 |
| 116 | MP0005375_adipose_tissue_phenotype | 0.66649622 |
| 117 | MP0001943_abnormal_respiration | 0.65145997 |
| 118 | MP0004043_abnormal_pH_regulation | 0.64260738 |
| 119 | MP0000750_abnormal_muscle_regeneration | 0.64247884 |
| 120 | MP0005535_abnormal_body_temperature | 0.64067430 |
| 121 | MP0006072_abnormal_retinal_apoptosis | 0.63705124 |
| 122 | MP0003385_abnormal_body_wall | 0.63388241 |
| 123 | MP0002896_abnormal_bone_mineralization | 0.62061089 |
| 124 | MP0001348_abnormal_lacrimal_gland | 0.61759688 |
| 125 | MP0005508_abnormal_skeleton_morphology | 0.61016868 |
| 126 | MP0010769_abnormal_survival | 0.60745483 |
| 127 | MP0003172_abnormal_lysosome_physiology | 0.60577137 |
| 128 | MP0002082_postnatal_lethality | 0.59562946 |
| 129 | MP0010770_preweaning_lethality | 0.59562946 |
| 130 | MP0000534_abnormal_ureter_morphology | 0.59341625 |
| 131 | MP0004215_abnormal_myocardial_fiber | 0.59042278 |
| 132 | MP0010768_mortality/aging | 0.56796816 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 5.76587473 |
| 2 | Focal motor seizures (HP:0011153) | 4.56878280 |
| 3 | Supranuclear gaze palsy (HP:0000605) | 4.31332353 |
| 4 | Focal seizures (HP:0007359) | 4.10194565 |
| 5 | Ankle clonus (HP:0011448) | 3.90484172 |
| 6 | Visual hallucinations (HP:0002367) | 3.67780252 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 3.46154006 |
| 8 | Action tremor (HP:0002345) | 3.42540022 |
| 9 | Epileptic encephalopathy (HP:0200134) | 3.39047768 |
| 10 | Limb dystonia (HP:0002451) | 3.29270979 |
| 11 | Poor eye contact (HP:0000817) | 3.20725843 |
| 12 | Peritonitis (HP:0002586) | 3.16749234 |
| 13 | Neurofibrillary tangles (HP:0002185) | 3.04403581 |
| 14 | Failure to thrive in infancy (HP:0001531) | 3.03796750 |
| 15 | Protrusio acetabuli (HP:0003179) | 2.91841453 |
| 16 | Mutism (HP:0002300) | 2.90722786 |
| 17 | Urinary urgency (HP:0000012) | 2.85600154 |
| 18 | Diplopia (HP:0000651) | 2.84444464 |
| 19 | Abnormality of binocular vision (HP:0011514) | 2.84444464 |
| 20 | Megalencephaly (HP:0001355) | 2.82819205 |
| 21 | Abnormal social behavior (HP:0012433) | 2.82770219 |
| 22 | Impaired social interactions (HP:0000735) | 2.82770219 |
| 23 | Absent/shortened dynein arms (HP:0200106) | 2.80897305 |
| 24 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.80897305 |
| 25 | Depression (HP:0000716) | 2.76607326 |
| 26 | Spastic gait (HP:0002064) | 2.75155119 |
| 27 | Broad-based gait (HP:0002136) | 2.74248213 |
| 28 | Premature rupture of membranes (HP:0001788) | 2.72628066 |
| 29 | Cerebral inclusion bodies (HP:0100314) | 2.72158290 |
| 30 | Shallow orbits (HP:0000586) | 2.70723737 |
| 31 | Termporal pattern (HP:0011008) | 2.69899528 |
| 32 | Insidious onset (HP:0003587) | 2.69899528 |
| 33 | Postural instability (HP:0002172) | 2.68071502 |
| 34 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.65517284 |
| 35 | Abnormal eating behavior (HP:0100738) | 2.65335269 |
| 36 | Abnormality of the corticospinal tract (HP:0002492) | 2.65277400 |
| 37 | Dysmetria (HP:0001310) | 2.64095009 |
| 38 | Type 1 muscle fiber predominance (HP:0003803) | 2.61402816 |
| 39 | Papilledema (HP:0001085) | 2.61072080 |
| 40 | Febrile seizures (HP:0002373) | 2.60635602 |
| 41 | Insomnia (HP:0100785) | 2.60336291 |
| 42 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.59380419 |
| 43 | Abnormality of the lower motor neuron (HP:0002366) | 2.58822467 |
| 44 | Torticollis (HP:0000473) | 2.58393749 |
| 45 | Distal upper limb amyotrophy (HP:0007149) | 2.57771797 |
| 46 | Upper limb amyotrophy (HP:0009129) | 2.57771797 |
| 47 | Atonic seizures (HP:0010819) | 2.56822609 |
| 48 | Dysdiadochokinesis (HP:0002075) | 2.53016006 |
| 49 | Turricephaly (HP:0000262) | 2.50881205 |
| 50 | Truncal ataxia (HP:0002078) | 2.50750861 |
| 51 | Hemiparesis (HP:0001269) | 2.49191250 |
| 52 | Distal lower limb amyotrophy (HP:0008944) | 2.46403333 |
| 53 | Gaze-evoked nystagmus (HP:0000640) | 2.45722390 |
| 54 | Cerebral aneurysm (HP:0004944) | 2.44202642 |
| 55 | Lower limb muscle weakness (HP:0007340) | 2.43256873 |
| 56 | Focal dystonia (HP:0004373) | 2.42594206 |
| 57 | Intention tremor (HP:0002080) | 2.40544953 |
| 58 | Genetic anticipation (HP:0003743) | 2.38935551 |
| 59 | Annular pancreas (HP:0001734) | 2.38667903 |
| 60 | Increased variability in muscle fiber diameter (HP:0003557) | 2.36844211 |
| 61 | Polyphagia (HP:0002591) | 2.36671576 |
| 62 | Generalized tonic-clonic seizures (HP:0002069) | 2.35614972 |
| 63 | Peripheral hypomyelination (HP:0007182) | 2.35362293 |
| 64 | Hyperacusis (HP:0010780) | 2.34960418 |
| 65 | Genu recurvatum (HP:0002816) | 2.34931134 |
| 66 | Mitral regurgitation (HP:0001653) | 2.34919156 |
| 67 | Achilles tendon contracture (HP:0001771) | 2.31590454 |
| 68 | Absence seizures (HP:0002121) | 2.29356748 |
| 69 | Anxiety (HP:0000739) | 2.28955311 |
| 70 | Atrophic scars (HP:0001075) | 2.27024018 |
| 71 | Amyotrophic lateral sclerosis (HP:0007354) | 2.23427892 |
| 72 | Sleep apnea (HP:0010535) | 2.21642212 |
| 73 | Bladder diverticulum (HP:0000015) | 2.21292855 |
| 74 | Excessive salivation (HP:0003781) | 2.20670479 |
| 75 | Drooling (HP:0002307) | 2.20670479 |
| 76 | Hand muscle atrophy (HP:0009130) | 2.18613888 |
| 77 | Progressive inability to walk (HP:0002505) | 2.17217811 |
| 78 | Apathy (HP:0000741) | 2.14612885 |
| 79 | EEG with generalized epileptiform discharges (HP:0011198) | 2.13475747 |
| 80 | Hypoplasia of the brainstem (HP:0002365) | 2.12924834 |
| 81 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.12924834 |
| 82 | Hypsarrhythmia (HP:0002521) | 2.12260891 |
| 83 | Spinal rigidity (HP:0003306) | 2.12130760 |
| 84 | Amblyopia (HP:0000646) | 2.11574135 |
| 85 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.10743132 |
| 86 | Craniofacial dystonia (HP:0012179) | 2.10706200 |
| 87 | Dialeptic seizures (HP:0011146) | 2.10390007 |
| 88 | Bronchomalacia (HP:0002780) | 2.10090029 |
| 89 | Epileptiform EEG discharges (HP:0011182) | 2.09715827 |
| 90 | Pheochromocytoma (HP:0002666) | 2.09707749 |
| 91 | Akinesia (HP:0002304) | 2.06846430 |
| 92 | Agitation (HP:0000713) | 2.06778895 |
| 93 | Long palpebral fissure (HP:0000637) | 2.06387891 |
| 94 | Clonus (HP:0002169) | 2.04127133 |
| 95 | Hyporeflexia of lower limbs (HP:0002600) | 2.04028599 |
| 96 | Stereotypic behavior (HP:0000733) | 2.03931935 |
| 97 | Bundle branch block (HP:0011710) | 2.03610088 |
| 98 | Broad metatarsal (HP:0001783) | 2.01785350 |
| 99 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.01132466 |
| 100 | Bradykinesia (HP:0002067) | 2.00676404 |
| 101 | Difficulty climbing stairs (HP:0003551) | 1.99821831 |
| 102 | Ventricular fibrillation (HP:0001663) | 1.99482803 |
| 103 | Pointed chin (HP:0000307) | 1.98410165 |
| 104 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.98399962 |
| 105 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.98399962 |
| 106 | Overriding aorta (HP:0002623) | 1.95577623 |
| 107 | Bowel diverticulosis (HP:0005222) | 1.95212610 |
| 108 | Lissencephaly (HP:0001339) | 1.94849246 |
| 109 | Abnormality of the Achilles tendon (HP:0005109) | 1.94731149 |
| 110 | Diminished motivation (HP:0000745) | 1.93787705 |
| 111 | Scanning speech (HP:0002168) | 1.93703357 |
| 112 | Neoplasm of the heart (HP:0100544) | 1.93423243 |
| 113 | Fragile skin (HP:0001030) | 1.91917381 |
| 114 | Pachygyria (HP:0001302) | 1.91186182 |
| 115 | Elfin facies (HP:0004428) | 1.90930612 |
| 116 | Onion bulb formation (HP:0003383) | 1.90761374 |
| 117 | Fetal akinesia sequence (HP:0001989) | 1.90416969 |
| 118 | Overgrowth (HP:0001548) | 1.88937420 |
| 119 | Hemiplegia (HP:0002301) | 1.88581556 |
| 120 | Distal lower limb muscle weakness (HP:0009053) | 1.88492877 |
| 121 | Absent speech (HP:0001344) | 1.87817765 |
| 122 | Retinal dysplasia (HP:0007973) | 1.87641705 |
| 123 | Increased connective tissue (HP:0009025) | 1.86787616 |
| 124 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.86456322 |
| 125 | Spinal canal stenosis (HP:0003416) | 1.86373865 |
| 126 | Renovascular hypertension (HP:0100817) | 1.83915929 |
| 127 | Hyperextensible skin (HP:0000974) | 1.83776116 |
| 128 | Lower limb amyotrophy (HP:0007210) | 1.81860281 |
| 129 | Hyperventilation (HP:0002883) | 1.81754195 |
| 130 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.81449239 |
| 131 | Impaired smooth pursuit (HP:0007772) | 1.81431038 |
| 132 | Foot dorsiflexor weakness (HP:0009027) | 1.81218309 |
| 133 | Neuronal loss in central nervous system (HP:0002529) | 1.80256503 |
| 134 | Rapidly progressive (HP:0003678) | 1.79241421 |
| 135 | Decreased motor nerve conduction velocity (HP:0003431) | 1.78181774 |
| 136 | Ulnar bowing (HP:0003031) | 1.77872630 |
| 137 | Sudden death (HP:0001699) | 1.77728600 |
| 138 | Aplasia involving bones of the extremities (HP:0009825) | 1.77567181 |
| 139 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.77567181 |
| 140 | Aplasia of the phalanges of the hand (HP:0009802) | 1.77567181 |
| 141 | Mild short stature (HP:0003502) | 1.77468227 |
| 142 | Stridor (HP:0010307) | 1.77434670 |
| 143 | Renal duplication (HP:0000075) | 1.77361063 |
| 144 | Hypoventilation (HP:0002791) | 1.76851096 |
| 145 | Obstructive sleep apnea (HP:0002870) | 1.76113442 |
| 146 | Hypercortisolism (HP:0001578) | 1.75546490 |
| 147 | Generalized hypotonia (HP:0001290) | 1.75502382 |
| 148 | Precocious puberty (HP:0000826) | 1.75252381 |
| 149 | Vascular tortuosity (HP:0004948) | 1.74270677 |
| 150 | Specific learning disability (HP:0001328) | 1.73924085 |
| 151 | Blue sclerae (HP:0000592) | 1.69152829 |
| 152 | Exercise-induced myalgia (HP:0003738) | 1.68877024 |
| 153 | Difficulty running (HP:0009046) | 1.68242441 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 4.55139626 |
| 2 | MAP3K9 | 3.34583133 |
| 3 | NTRK3 | 3.22918032 |
| 4 | PRKD3 | 2.93064715 |
| 5 | EPHA4 | 2.58764829 |
| 6 | MINK1 | 2.54592895 |
| 7 | MAP3K4 | 2.38401228 |
| 8 | NTRK2 | 2.36719896 |
| 9 | PAK6 | 2.31420059 |
| 10 | EPHB2 | 2.09557942 |
| 11 | ICK | 2.08297073 |
| 12 | NTRK1 | 1.85614061 |
| 13 | KSR1 | 1.80891058 |
| 14 | DAPK2 | 1.76520341 |
| 15 | TYRO3 | 1.74995112 |
| 16 | PHKG1 | 1.70321183 |
| 17 | PHKG2 | 1.70321183 |
| 18 | UHMK1 | 1.64225652 |
| 19 | MAP2K7 | 1.54223067 |
| 20 | KSR2 | 1.51800286 |
| 21 | CAMKK1 | 1.49683346 |
| 22 | CDK5 | 1.48876887 |
| 23 | TTN | 1.46023731 |
| 24 | ARAF | 1.45782864 |
| 25 | SIK1 | 1.39709455 |
| 26 | MAPK13 | 1.37894530 |
| 27 | SIK2 | 1.35882593 |
| 28 | PRPF4B | 1.33668249 |
| 29 | MAP3K11 | 1.33391785 |
| 30 | IRAK2 | 1.28435375 |
| 31 | STK38 | 1.25286277 |
| 32 | PDK3 | 1.21828514 |
| 33 | PDK4 | 1.21828514 |
| 34 | PINK1 | 1.17693697 |
| 35 | MARK2 | 1.15952942 |
| 36 | TNIK | 1.14954552 |
| 37 | EEF2K | 1.14571205 |
| 38 | LIMK1 | 1.13331758 |
| 39 | STK39 | 1.13022890 |
| 40 | SIK3 | 1.12627432 |
| 41 | CASK | 1.12494390 |
| 42 | SGK223 | 1.12441983 |
| 43 | SGK494 | 1.12441983 |
| 44 | TESK1 | 1.12150437 |
| 45 | MAP2K4 | 1.10792930 |
| 46 | CAMK1G | 1.08800078 |
| 47 | MAPK12 | 1.08309804 |
| 48 | TAOK1 | 1.07721857 |
| 49 | FGFR2 | 1.06872637 |
| 50 | BCR | 1.05059411 |
| 51 | CDK19 | 1.04088175 |
| 52 | PNCK | 1.02610727 |
| 53 | PRKD2 | 1.02338195 |
| 54 | LMTK2 | 0.99423289 |
| 55 | PKN2 | 0.99082946 |
| 56 | CDK18 | 0.98140443 |
| 57 | PTK2 | 0.96440749 |
| 58 | PAK3 | 0.96207239 |
| 59 | PKN1 | 0.95799279 |
| 60 | SMG1 | 0.95418669 |
| 61 | CDK14 | 0.92196143 |
| 62 | RET | 0.91786683 |
| 63 | PRKCG | 0.91771900 |
| 64 | CDK15 | 0.91686569 |
| 65 | LATS2 | 0.89252296 |
| 66 | BRAF | 0.87942949 |
| 67 | PTK2B | 0.87516428 |
| 68 | GRK5 | 0.86758761 |
| 69 | DYRK2 | 0.86013988 |
| 70 | PRKCH | 0.84255223 |
| 71 | STK11 | 0.83683977 |
| 72 | OXSR1 | 0.82669698 |
| 73 | MAP3K2 | 0.81324604 |
| 74 | DYRK1B | 0.79796946 |
| 75 | WNK1 | 0.79456156 |
| 76 | CDK11A | 0.79431590 |
| 77 | CSNK1G2 | 0.78070399 |
| 78 | DMPK | 0.75269234 |
| 79 | CAMK2A | 0.74974440 |
| 80 | FES | 0.74182810 |
| 81 | WNK4 | 0.74017929 |
| 82 | CAMK2G | 0.70725172 |
| 83 | PDGFRA | 0.70341795 |
| 84 | MTOR | 0.68331916 |
| 85 | CAMK1 | 0.66800885 |
| 86 | PDPK1 | 0.66390224 |
| 87 | CAMK2B | 0.65784841 |
| 88 | PRKCZ | 0.64577825 |
| 89 | PDK1 | 0.63897795 |
| 90 | TNK2 | 0.62923880 |
| 91 | CDC42BPA | 0.62283499 |
| 92 | RIPK1 | 0.62262447 |
| 93 | NEK6 | 0.62056791 |
| 94 | FER | 0.61824582 |
| 95 | DYRK1A | 0.60440390 |
| 96 | MAP3K13 | 0.60420448 |
| 97 | ALK | 0.59961717 |
| 98 | ERN1 | 0.59560657 |
| 99 | ROCK1 | 0.59326467 |
| 100 | PLK2 | 0.59165297 |
| 101 | TAOK2 | 0.58811656 |
| 102 | RIPK4 | 0.58189957 |
| 103 | PDK2 | 0.56942175 |
| 104 | DDR2 | 0.56318506 |
| 105 | MOS | 0.54764002 |
| 106 | DAPK3 | 0.54345868 |
| 107 | CAMK4 | 0.54309109 |
| 108 | CAMKK2 | 0.53724483 |
| 109 | SGK3 | 0.50939239 |
| 110 | SGK2 | 0.50498417 |
| 111 | DAPK1 | 0.50312865 |
| 112 | MAPKAPK5 | 0.50127463 |
| 113 | RPS6KC1 | 0.49922050 |
| 114 | RPS6KL1 | 0.49922050 |
| 115 | FYN | 0.49846394 |
| 116 | SGK1 | 0.49367280 |
| 117 | MAP3K7 | 0.49006357 |
| 118 | ROCK2 | 0.48649438 |
| 119 | RPS6KA2 | 0.48509738 |
| 120 | WNK3 | 0.47267722 |
| 121 | MAP3K1 | 0.47122465 |
| 122 | PAK2 | 0.46758278 |
| 123 | PRKCE | 0.46553286 |
| 124 | CAMK1D | 0.46357019 |
| 125 | EPHB1 | 0.46263742 |
| 126 | TRIB3 | 0.45135088 |
| 127 | MAPK4 | 0.44841682 |
| 128 | ERBB3 | 0.44043055 |
| 129 | CSNK1G3 | 0.43649906 |
| 130 | RPS6KA3 | 0.43556207 |
| 131 | PDGFRB | 0.43016006 |
| 132 | ERBB2 | 0.42443987 |
| 133 | MAPK10 | 0.41998025 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.86867384 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 2.77368104 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.38862833 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.37427716 |
| 5 | Olfactory transduction_Homo sapiens_hsa04740 | 2.33134489 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.25353104 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 2.23650798 |
| 8 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.23598379 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.10440428 |
| 10 | Long-term potentiation_Homo sapiens_hsa04720 | 2.07361209 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.01833439 |
| 12 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.00471986 |
| 13 | Insulin secretion_Homo sapiens_hsa04911 | 1.84843158 |
| 14 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.83687965 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.82732820 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.79123414 |
| 17 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.78507000 |
| 18 | Cocaine addiction_Homo sapiens_hsa05030 | 1.77148230 |
| 19 | Axon guidance_Homo sapiens_hsa04360 | 1.72384129 |
| 20 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.70302285 |
| 21 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.64684796 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.51649366 |
| 23 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.49818505 |
| 24 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.48569531 |
| 25 | Gap junction_Homo sapiens_hsa04540 | 1.45315035 |
| 26 | Long-term depression_Homo sapiens_hsa04730 | 1.41782631 |
| 27 | Taste transduction_Homo sapiens_hsa04742 | 1.36702459 |
| 28 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.34726872 |
| 29 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.31520656 |
| 30 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.27266390 |
| 31 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.25937990 |
| 32 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.24941564 |
| 33 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.24721377 |
| 34 | Glioma_Homo sapiens_hsa05214 | 1.22600691 |
| 35 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.21893963 |
| 36 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.20664289 |
| 37 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.17073617 |
| 38 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.10962317 |
| 39 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.09563027 |
| 40 | Melanogenesis_Homo sapiens_hsa04916 | 1.07033482 |
| 41 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.06447081 |
| 42 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.04120413 |
| 43 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.03828703 |
| 44 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.02196645 |
| 45 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.98654234 |
| 46 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.98572863 |
| 47 | Focal adhesion_Homo sapiens_hsa04510 | 0.98357941 |
| 48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.96450981 |
| 49 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.92803238 |
| 50 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.89294620 |
| 51 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.89037531 |
| 52 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.88853717 |
| 53 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.87366273 |
| 54 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.87189441 |
| 55 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.86990976 |
| 56 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.86395833 |
| 57 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.85689766 |
| 58 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.85678172 |
| 59 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.84270337 |
| 60 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.83898131 |
| 61 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.82740027 |
| 62 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.81419016 |
| 63 | Endocytosis_Homo sapiens_hsa04144 | 0.80893970 |
| 64 | Phototransduction_Homo sapiens_hsa04744 | 0.80836750 |
| 65 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.80339158 |
| 66 | Endometrial cancer_Homo sapiens_hsa05213 | 0.79786837 |
| 67 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.78953143 |
| 68 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.77792952 |
| 69 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.76103824 |
| 70 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.74924878 |
| 71 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.71799803 |
| 72 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.71629001 |
| 73 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.71584967 |
| 74 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.70833518 |
| 75 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.70108294 |
| 76 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.69147343 |
| 77 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.64322488 |
| 78 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.63517318 |
| 79 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.61874362 |
| 80 | Alcoholism_Homo sapiens_hsa05034 | 0.61280862 |
| 81 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.61003812 |
| 82 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.60770116 |
| 83 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.60769996 |
| 84 | Amoebiasis_Homo sapiens_hsa05146 | 0.60686072 |
| 85 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.60639480 |
| 86 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.60629688 |
| 87 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.60355569 |
| 88 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.60060618 |
| 89 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.59980135 |
| 90 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.59678238 |
| 91 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.58142251 |
| 92 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.56521882 |
| 93 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.55094613 |
| 94 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.54398377 |
| 95 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.54297983 |
| 96 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.53357718 |
| 97 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.52603321 |
| 98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.52272971 |
| 99 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.52171892 |
| 100 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.49774150 |
| 101 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.49615031 |
| 102 | Prion diseases_Homo sapiens_hsa05020 | 0.49103006 |
| 103 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.48469855 |
| 104 | Colorectal cancer_Homo sapiens_hsa05210 | 0.48460495 |
| 105 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.45618667 |
| 106 | Bladder cancer_Homo sapiens_hsa05219 | 0.45291886 |
| 107 | Adherens junction_Homo sapiens_hsa04520 | 0.45227869 |
| 108 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.44667958 |
| 109 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.44399306 |
| 110 | Tight junction_Homo sapiens_hsa04530 | 0.43340364 |
| 111 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.42812078 |
| 112 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.42341990 |
| 113 | Bile secretion_Homo sapiens_hsa04976 | 0.40919914 |
| 114 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.40854686 |
| 115 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.40309366 |
| 116 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.39537870 |

