EVPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intermediate filament organization (GO:0045109)8.44561174
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.64632156
3multicellular organismal water homeostasis (GO:0050891)7.37487851
4* keratinocyte differentiation (GO:0030216)7.32496520
5* peptide cross-linking (GO:0018149)7.13038070
6water homeostasis (GO:0030104)6.05226851
7* epidermis development (GO:0008544)5.98227597
8* epidermal cell differentiation (GO:0009913)5.80663584
9skin morphogenesis (GO:0043589)5.61890905
10virion attachment to host cell (GO:0019062)5.32183950
11adhesion of symbiont to host cell (GO:0044650)5.32183950
12intermediate filament cytoskeleton organization (GO:0045104)5.15004418
13intermediate filament-based process (GO:0045103)4.97606875
14ectoderm development (GO:0007398)4.97073131
15keratinocyte proliferation (GO:0043616)4.79831677
16keratinocyte development (GO:0003334)4.71810535
17activation of Rac GTPase activity (GO:0032863)4.45690406
18adhesion of symbiont to host (GO:0044406)4.38750072
19lung epithelium development (GO:0060428)4.30006525
20cell-substrate junction assembly (GO:0007044)4.18223710
21semaphorin-plexin signaling pathway (GO:0071526)4.08883148
22positive regulation of Cdc42 GTPase activity (GO:0043089)4.02765355
23negative regulation of keratinocyte proliferation (GO:0010839)4.02026291
24skin development (GO:0043588)3.96840428
25negative regulation of cell fate specification (GO:0009996)3.92911152
26hair follicle morphogenesis (GO:0031069)3.89606339
27positive regulation of keratinocyte differentiation (GO:0045618)3.88197569
28regulation of cholesterol homeostasis (GO:2000188)3.82641235
29epithelial cell-cell adhesion (GO:0090136)3.74393291
30atrioventricular valve morphogenesis (GO:0003181)3.73021656
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64561011
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.39860066
33gap junction assembly (GO:0016264)3.37134415
34regulation of ruffle assembly (GO:1900027)3.36529248
35ventricular cardiac muscle cell action potential (GO:0086005)3.36087299
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.34662430
37polarized epithelial cell differentiation (GO:0030859)3.34034128
38positive regulation of epidermis development (GO:0045684)3.32735842
39branching involved in mammary gland duct morphogenesis (GO:0060444)3.29754289
40COPI coating of Golgi vesicle (GO:0048205)3.22889618
41Golgi transport vesicle coating (GO:0048200)3.22889618
42negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.22352816
43endothelial cell chemotaxis (GO:0035767)3.20908432
44establishment of planar polarity (GO:0001736)3.20631462
45establishment of tissue polarity (GO:0007164)3.20631462
46regulation of cardioblast differentiation (GO:0051890)3.17253332
47cell-cell junction maintenance (GO:0045217)3.13486694
48regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.13235382
49hair cycle process (GO:0022405)3.10035352
50molting cycle process (GO:0022404)3.10035352
51long-chain fatty acid biosynthetic process (GO:0042759)3.09146144
52chemical homeostasis within a tissue (GO:0048875)3.06120600
53positive regulation of epidermal cell differentiation (GO:0045606)3.05421190
54plasma membrane repair (GO:0001778)3.04526392
55phosphatidylinositol acyl-chain remodeling (GO:0036149)3.04471200
56regulation of keratinocyte differentiation (GO:0045616)3.03934836
57regulation of endothelial cell chemotaxis (GO:2001026)3.02854198
58apical protein localization (GO:0045176)3.01864713
59sphingosine metabolic process (GO:0006670)3.01580113
60regulation of hair follicle development (GO:0051797)3.00815080
61interferon-gamma secretion (GO:0072643)2.99124444
62regulation of epidermis development (GO:0045682)2.97404787
63establishment of apical/basal cell polarity (GO:0035089)2.96622669
64tooth mineralization (GO:0034505)2.96116535
65asymmetric protein localization (GO:0008105)2.95510549
66dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.94899207
67* epithelium development (GO:0060429)2.94891659
68negative regulation of cell fate commitment (GO:0010454)2.94464348
69sphingoid metabolic process (GO:0046519)2.94420344
70intestinal epithelial cell development (GO:0060576)2.93836815
71cell-cell junction assembly (GO:0007043)2.93022081
72regulation of establishment of planar polarity (GO:0090175)2.92701253
73citrulline biosynthetic process (GO:0019240)2.89780962
74focal adhesion assembly (GO:0048041)2.87028261
75cell-substrate adherens junction assembly (GO:0007045)2.87028261
76negative regulation of fatty acid transport (GO:2000192)2.86052137
77phosphatidylserine acyl-chain remodeling (GO:0036150)2.84035487
78adherens junction assembly (GO:0034333)2.83848597
79regulation of Cdc42 GTPase activity (GO:0043088)2.83000038
80morphogenesis of embryonic epithelium (GO:0016331)2.80824119
81eyelid development in camera-type eye (GO:0061029)2.78403736
82citrulline metabolic process (GO:0000052)2.77083203
83regulation of heart rate by cardiac conduction (GO:0086091)2.76688032
84cell wall macromolecule catabolic process (GO:0016998)2.76666009
85cell wall macromolecule metabolic process (GO:0044036)2.76666009
86diol metabolic process (GO:0034311)2.75315530
87lipoxygenase pathway (GO:0019372)2.72644634
88proline metabolic process (GO:0006560)2.72600165
89negative regulation of cell size (GO:0045792)2.72385181
90positive regulation of hair cycle (GO:0042635)2.71927928
91positive regulation of hair follicle development (GO:0051798)2.71927928
92regulation of hair cycle (GO:0042634)2.70825506
93non-canonical Wnt signaling pathway (GO:0035567)2.70263931
94face development (GO:0060324)2.68671103
95negative regulation of viral release from host cell (GO:1902187)2.67974847
96cell communication involved in cardiac conduction (GO:0086065)2.66600198
97regulation of cell fate specification (GO:0042659)2.63824672
98regulation of epidermal cell differentiation (GO:0045604)2.63746063
99apoptotic process involved in morphogenesis (GO:0060561)2.60070208
100peptidyl-tyrosine autophosphorylation (GO:0038083)2.58720707
101regulation of keratinocyte proliferation (GO:0010837)2.58092908
102establishment of epithelial cell polarity (GO:0090162)2.57570053
103branching involved in salivary gland morphogenesis (GO:0060445)2.56759691
104cell junction maintenance (GO:0034331)2.56439165
105regulation of fatty acid beta-oxidation (GO:0031998)2.56356303
106hormone catabolic process (GO:0042447)2.54961461
107maternal placenta development (GO:0001893)2.54430635
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52711974
109regulation of cholesterol biosynthetic process (GO:0045540)2.52095339
110filopodium assembly (GO:0046847)2.51668684
111cell junction assembly (GO:0034329)2.51117701
112mesodermal cell differentiation (GO:0048333)2.50637346
113cell junction organization (GO:0034330)2.49872981
114phospholipid scrambling (GO:0017121)2.49212814
115hair follicle development (GO:0001942)2.48396703
116insulin-like growth factor receptor signaling pathway (GO:0048009)2.47611491
117embryonic eye morphogenesis (GO:0048048)2.47607822
118cell differentiation involved in embryonic placenta development (GO:0060706)2.47556444
119ear development (GO:0043583)2.47285883
120cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.45282578
121phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.44269167
122odontogenesis (GO:0042476)2.44226153
123epithelial cell fate commitment (GO:0072148)2.42228391
124fatty acid elongation (GO:0030497)2.41325868
125linoleic acid metabolic process (GO:0043651)2.40739096
126regulation of hippo signaling (GO:0035330)2.38909754
127odontogenesis of dentin-containing tooth (GO:0042475)2.36967868
128surfactant homeostasis (GO:0043129)2.36171521
129oocyte development (GO:0048599)2.36130378
130peptide catabolic process (GO:0043171)2.35932578
131regulation of chemokine secretion (GO:0090196)2.34599134
132cell surface receptor signaling pathway involved in heart development (GO:0061311)2.34593912
133lymph vessel development (GO:0001945)2.34323083
134phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.33856720
135cardiac conduction (GO:0061337)2.32780618
136negative regulation of stress fiber assembly (GO:0051497)2.32324294
137glucosamine-containing compound catabolic process (GO:1901072)2.30220382
138epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29485648
139cardiac right ventricle morphogenesis (GO:0003215)2.28371959
140renal system development (GO:0072001)2.27811251
141Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.27296542
142vitamin A metabolic process (GO:0006776)2.25462006
143skeletal muscle adaptation (GO:0043501)2.24625979
144detection of bacterium (GO:0016045)2.22669481
145regulation of skeletal muscle contraction (GO:0014819)2.22528673
146molting cycle (GO:0042303)16.0257984
147hair cycle (GO:0042633)16.0257984
148* keratinization (GO:0031424)14.2030771
149desmosome organization (GO:0002934)13.8510993
150hemidesmosome assembly (GO:0031581)11.4633459
151establishment of skin barrier (GO:0061436)11.4372207
152regulation of water loss via skin (GO:0033561)10.5380494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.06873380
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.13319431
3ZNF263_19887448_ChIP-Seq_K562_Human2.99936804
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.58110043
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.51660037
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37309200
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34387708
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.29583512
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.07786128
10* TP63_17297297_ChIP-ChIP_HaCaT_Human13.5711011
11FOXO3_23340844_ChIP-Seq_DLD1_Human1.98473201
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.96399525
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.96399525
14RACK7_27058665_Chip-Seq_MCF-7_Human1.87860711
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.85024993
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81865379
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74735459
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72967795
19* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70831922
20KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64304751
21ATF3_27146783_Chip-Seq_COLON_Human1.59041188
22TP63_22573176_ChIP-Seq_HFKS_Human1.58136223
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.58070264
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55169734
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54977512
26ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51447849
27LXR_22292898_ChIP-Seq_THP-1_Human1.48551322
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47119735
29SOX2_20726797_ChIP-Seq_SW620_Human1.45481380
30UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42495592
31* KLF5_25053715_ChIP-Seq_YYC3_Human1.41092432
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37915418
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36057404
34CTCF_27219007_Chip-Seq_Bcells_Human1.35751791
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35603341
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33574517
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32459090
38* GATA6_25053715_ChIP-Seq_YYC3_Human1.32284048
39VDR_21846776_ChIP-Seq_THP-1_Human1.29504272
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28643713
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25859777
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23200793
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22826199
44TP63_23658742_ChIP-Seq_EP156T_Human1.22644525
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22638886
46* GATA4_25053715_ChIP-Seq_YYC3_Human1.22281005
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.22145384
48CTCF_20526341_ChIP-Seq_ESCs_Human1.19167140
49* GATA3_24758297_ChIP-Seq_MCF-7_Human1.19141521
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18562514
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16252980
52BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15956929
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14470283
54UBF1/2_26484160_Chip-Seq_HMECs_Human1.14075637
55TP53_22127205_ChIP-Seq_IMR90_Human1.13583903
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13296225
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.12317137
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12147761
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11614614
60P68_20966046_ChIP-Seq_HELA_Human1.11450476
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11018165
62P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.10846304
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.09283509
64CLOCK_20551151_ChIP-Seq_293T_Human1.09217385
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08997128
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.08874478
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.08870423
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08616459
69AHR_22903824_ChIP-Seq_MCF-7_Human1.07746497
70KDM2B_26808549_Chip-Seq_K562_Human1.06754969
71MYC_22102868_ChIP-Seq_BL_Human1.06464224
72* CDX2_20551321_ChIP-Seq_CACO-2_Human1.06373938
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05465773
74E2F1_20622854_ChIP-Seq_HELA_Human1.04841938
75BCOR_27268052_Chip-Seq_Bcells_Human1.03812040
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.03344500
77* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02354666
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02248923
79CJUN_26792858_Chip-Seq_BT549_Human1.01667657
80* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01153515
81* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00626038
82RXR_22108803_ChIP-Seq_LS180_Human0.99606584
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99535343
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99463611
85* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97707418
86ERG_21242973_ChIP-ChIP_JURKAT_Human0.97165371
87EGR1_19032775_ChIP-ChIP_M12_Human0.96941045
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96894440
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96113862
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95704918
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.95543378
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94680532
93CHD1_26751641_Chip-Seq_LNCaP_Human0.94306039
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93474407
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93117884
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91496914
97KDM2B_26808549_Chip-Seq_DND41_Human0.90564757
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.90044210
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89928572
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89660517
101* TP53_20018659_ChIP-ChIP_R1E_Mouse0.89647458
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89053564
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88751575
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87990821
105ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87217054
106SMC4_20622854_ChIP-Seq_HELA_Human0.86554750
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85683636
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85013624
109BCL6_27268052_Chip-Seq_Bcells_Human0.84354977
110TCF7_22412390_ChIP-Seq_EML_Mouse0.84115243
111* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83467210
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.82768735
113* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82602230
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.81921171
115GATA6_21074721_ChIP-Seq_CACO-2_Human0.81877340
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.81866692
117CREB1_26743006_Chip-Seq_LNCaP_Human0.81757006
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81089549
119CEBPB_22108803_ChIP-Seq_LS180_Human0.79966152
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79600578
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78856179
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.78211674
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.78211674
124PHF8_20622854_ChIP-Seq_HELA_Human0.77532606
125ERG_20517297_ChIP-Seq_VCAP_Human0.76883503
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74598053
127CSB_26484114_Chip-Seq_FIBROBLAST_Human0.73419895
128* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73348535
129NANOG_20526341_ChIP-Seq_ESCs_Human0.72252697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.08781314
2MP0005275_abnormal_skin_tensile5.96619329
3MP0000579_abnormal_nail_morphology5.87241390
4MP0010234_abnormal_vibrissa_follicle5.37537453
5MP0005501_abnormal_skin_physiology4.50292568
6MP0003705_abnormal_hypodermis_morpholog3.76264407
7MP0002098_abnormal_vibrissa_morphology3.75813603
8MP0000383_abnormal_hair_follicle3.43776660
9MP0002060_abnormal_skin_morphology3.35308888
10MP0000647_abnormal_sebaceous_gland3.27220724
11MP0010678_abnormal_skin_adnexa3.26451883
12* MP0001216_abnormal_epidermal_layer3.19477516
13MP0002254_reproductive_system_inflammat3.12476850
14MP0000467_abnormal_esophagus_morphology2.91813189
15MP0003941_abnormal_skin_development2.90417880
16MP0010771_integument_phenotype2.85297627
17MP0000377_abnormal_hair_follicle2.74738866
18MP0003453_abnormal_keratinocyte_physiol2.70701228
19MP0004381_abnormal_hair_follicle2.68732465
20MP0000427_abnormal_hair_cycle2.60858966
21MP0004947_skin_inflammation2.45541180
22MP0000762_abnormal_tongue_morphology2.30094997
23MP0002234_abnormal_pharynx_morphology2.24591152
24MP0003566_abnormal_cell_adhesion1.93916891
25MP0001243_abnormal_dermal_layer1.86996608
26MP0009780_abnormal_chondrocyte_physiolo1.74903989
27MP0009931_abnormal_skin_appearance1.69742186
28MP0000367_abnormal_coat/_hair1.59146084
29MP0001849_ear_inflammation1.52061852
30MP0001191_abnormal_skin_condition1.50295106
31MP0000566_synostosis1.41263605
32MP0004264_abnormal_extraembryonic_tissu1.39576260
33MP0009053_abnormal_anal_canal1.36726130
34MP0004185_abnormal_adipocyte_glucose1.33359377
35MP0002877_abnormal_melanocyte_morpholog1.18292616
36MP0000537_abnormal_urethra_morphology1.17215721
37MP0010352_gastrointestinal_tract_polyps1.14205365
38MP0005083_abnormal_biliary_tract1.11572354
39MP0001346_abnormal_lacrimal_gland1.07508695
40MP0005451_abnormal_body_composition1.06276642
41MP0005409_darkened_coat_color0.95194558
42MP0000538_abnormal_urinary_bladder0.95194201
43MP0010030_abnormal_orbit_morphology0.91222697
44MP0004043_abnormal_pH_regulation0.88901974
45MP0002089_abnormal_postnatal_growth/wei0.84486688
46MP0006054_spinal_hemorrhage0.84202770
47MP0005023_abnormal_wound_healing0.82690930
48MP0001851_eye_inflammation0.81564939
49MP0008260_abnormal_autophagy0.79963820
50MP0001340_abnormal_eyelid_morphology0.79871394
51MP0003191_abnormal_cellular_cholesterol0.79405167
52MP0008438_abnormal_cutaneous_collagen0.77310061
53MP0000462_abnormal_digestive_system0.76803403
54MP0000465_gastrointestinal_hemorrhage0.72457166
55MP0000678_abnormal_parathyroid_gland0.71026465
56MP0004272_abnormal_basement_membrane0.70543056
57MP0000858_altered_metastatic_potential0.69829526
58MP0003878_abnormal_ear_physiology0.69372189
59MP0005377_hearing/vestibular/ear_phenot0.69372189
60MP0004019_abnormal_vitamin_homeostasis0.69115125
61MP0001873_stomach_inflammation0.67989121
62MP0008961_abnormal_basal_metabolism0.66725960
63MP0002095_abnormal_skin_pigmentation0.65887823
64MP0005058_abnormal_lysosome_morphology0.64990755
65MP0005076_abnormal_cell_differentiation0.64766073
66MP0003315_abnormal_perineum_morphology0.64758626
67MP0003115_abnormal_respiratory_system0.63339484
68MP0000627_abnormal_mammary_gland0.62840943
69MP0009379_abnormal_foot_pigmentation0.61793745
70MP0001784_abnormal_fluid_regulation0.61157684
71MP0001666_abnormal_nutrient_absorption0.59853722
72MP0006138_congestive_heart_failure0.59704520
73MP0002177_abnormal_outer_ear0.57891970
74MP0003755_abnormal_palate_morphology0.57361705
75MP0003638_abnormal_response/metabolism_0.55150721
76MP0002111_abnormal_tail_morphology0.53860640
77MP0003300_gastrointestinal_ulcer0.53112370
78MP0000516_abnormal_urinary_system0.52828479
79MP0005367_renal/urinary_system_phenotyp0.52828479
80MP0001348_abnormal_lacrimal_gland0.51919727
81MP0005360_urolithiasis0.51865761
82MP0005666_abnormal_adipose_tissue0.51806831
83MP0002249_abnormal_larynx_morphology0.50663848
84MP0005375_adipose_tissue_phenotype0.49700518
85MP0005670_abnormal_white_adipose0.47716855
86MP0002282_abnormal_trachea_morphology0.46524296
87MP0000470_abnormal_stomach_morphology0.46272093
88MP0004197_abnormal_fetal_growth/weight/0.45471492
89MP0005257_abnormal_intraocular_pressure0.44523239
90MP0004782_abnormal_surfactant_physiolog0.43939817
91MP0000013_abnormal_adipose_tissue0.43429045
92MP0002896_abnormal_bone_mineralization0.43045205
93MP0003183_abnormal_peptide_metabolism0.42952635
94MP0003091_abnormal_cell_migration0.42340789
95MP0000613_abnormal_salivary_gland0.42200457
96MP0002009_preneoplasia0.40398213
97MP0008875_abnormal_xenobiotic_pharmacok0.40259473
98MP0002086_abnormal_extraembryonic_tissu0.39062573
99MP0003045_fibrosis0.38219674
100MP0008789_abnormal_olfactory_epithelium0.37905888
101MP0002166_altered_tumor_susceptibility0.37121435
102MP0005248_abnormal_Harderian_gland0.36671476
103MP0005394_taste/olfaction_phenotype0.36647984
104MP0005499_abnormal_olfactory_system0.36647984
105MP0000751_myopathy0.36513061
106MP0001765_abnormal_ion_homeostasis0.36277214
107MP0004858_abnormal_nervous_system0.36177270
108MP0002006_tumorigenesis0.36013777
109MP0003385_abnormal_body_wall0.34703026
110MP0000003_abnormal_adipose_tissue0.33653661
111MP0002909_abnormal_adrenal_gland0.33235022
112MP0000477_abnormal_intestine_morphology0.32343593
113MP0002233_abnormal_nose_morphology0.32336502
114MP0001958_emphysema0.32053606
115MP0001188_hyperpigmentation0.31972824
116MP0008004_abnormal_stomach_pH0.31558518
117MP0000432_abnormal_head_morphology0.30114480
118MP0004885_abnormal_endolymph0.29385034
119MP0000733_abnormal_muscle_development0.28938253
120MP0003011_delayed_dark_adaptation0.25912063
121MP0003950_abnormal_plasma_membrane0.25591465
122MP0001756_abnormal_urination0.25195743
123MP0005508_abnormal_skeleton_morphology0.22500256
124MP0003763_abnormal_thymus_physiology0.22305922

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)8.27830645
2Woolly hair (HP:0002224)7.47375248
3Milia (HP:0001056)7.24294461
4Plantar hyperkeratosis (HP:0007556)7.18020633
5Abnormality of nail color (HP:0100643)7.00867406
6Pili torti (HP:0003777)6.74221822
7Onycholysis (HP:0001806)6.67056275
8Fragile nails (HP:0001808)6.52892380
9Palmoplantar hyperkeratosis (HP:0000972)6.45898214
10Palmar hyperkeratosis (HP:0010765)6.07976618
11Right ventricular cardiomyopathy (HP:0011663)6.06662091
12Increased IgE level (HP:0003212)5.92701896
13Thick nail (HP:0001805)5.62571525
14Nail dystrophy (HP:0008404)5.27268720
15Atrophic scars (HP:0001075)4.72128641
16Alopecia of scalp (HP:0002293)4.63697279
17Conjunctival hamartoma (HP:0100780)4.59280220
18Abnormal blistering of the skin (HP:0008066)4.42932682
19Abnormal hair laboratory examination (HP:0003328)4.23295667
20Erythema (HP:0010783)3.99804123
21Congenital ichthyosiform erythroderma (HP:0007431)3.98751337
22Erythroderma (HP:0001019)3.74675300
23Follicular hyperkeratosis (HP:0007502)3.52231695
24Abnormality of the axillary hair (HP:0100134)3.43852098
25Abnormality of secondary sexual hair (HP:0009888)3.43852098
26Oral leukoplakia (HP:0002745)3.39002041
27Lip pit (HP:0100267)3.35976070
28Fragile skin (HP:0001030)3.24958681
29Advanced eruption of teeth (HP:0006288)3.19125615
30Ridged nail (HP:0001807)3.17481343
31Natal tooth (HP:0000695)3.17165974
32Curly hair (HP:0002212)3.11323727
33Increased connective tissue (HP:0009025)3.07813735
34Abnormality of hair growth rate (HP:0011363)3.05303491
35Slow-growing hair (HP:0002217)3.05303491
36Broad face (HP:0000283)3.03663201
37Ectropion (HP:0000656)3.01983466
38Hamartoma of the eye (HP:0010568)3.01086628
39Corneal erosion (HP:0200020)2.96565289
40Brittle hair (HP:0002299)2.94389413
41Palmoplantar keratoderma (HP:0000982)2.89664325
42Flat acetabular roof (HP:0003180)2.80439608
43Aplasia cutis congenita (HP:0001057)2.75992839
44Ventricular tachycardia (HP:0004756)2.72392517
45Sparse eyelashes (HP:0000653)2.67977836
46Type 1 muscle fiber predominance (HP:0003803)2.58414442
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.52370046
48Fatigable weakness (HP:0003473)2.51991825
49Abnormality of the neuromuscular junction (HP:0003398)2.51991825
50Hypohidrosis (HP:0000966)2.49066147
51Hyporeflexia of lower limbs (HP:0002600)2.47832248
52Thin bony cortex (HP:0002753)2.43904928
53Oligodontia (HP:0000677)2.41297827
54Parakeratosis (HP:0001036)2.36436563
55Distal lower limb muscle weakness (HP:0009053)2.35196568
56Septate vagina (HP:0001153)2.34674695
57Blepharitis (HP:0000498)2.31272237
58Amelogenesis imperfecta (HP:0000705)2.30818498
59Anonychia (HP:0001798)2.29599213
60Pruritus (HP:0000989)2.29255251
61Hyperacusis (HP:0010780)2.28653531
62Gangrene (HP:0100758)2.28175706
63Sparse scalp hair (HP:0002209)2.26996464
64Selective tooth agenesis (HP:0001592)2.24767029
65Hypoplasia of dental enamel (HP:0006297)2.20572747
66Round ear (HP:0100830)2.19907203
67Malnutrition (HP:0004395)2.18621527
68Abnormality of permanent molar morphology (HP:0011071)2.11995470
69Abnormality of the dental root (HP:0006486)2.11995470
70Taurodontia (HP:0000679)2.11995470
71Myopathic facies (HP:0002058)2.10649359
72Germ cell neoplasia (HP:0100728)2.09407427
73Nasolacrimal duct obstruction (HP:0000579)2.09159282
74Ventricular fibrillation (HP:0001663)2.06923395
75Acanthosis nigricans (HP:0000956)2.05593444
76Laryngomalacia (HP:0001601)2.04358474
77Hyperactive renin-angiotensin system (HP:0000841)2.03132652
78Mildly elevated creatine phosphokinase (HP:0008180)2.01575234
79Abnormality of the gastric mucosa (HP:0004295)2.00198703
80Short nail (HP:0001799)1.98630754
81Down-sloping shoulders (HP:0200021)1.96187478
82Abnormality of molar (HP:0011077)1.95610476
83Abnormality of molar morphology (HP:0011070)1.95610476
84Dehydration (HP:0001944)1.94154776
85Cervical subluxation (HP:0003308)1.91489319
86Obstructive sleep apnea (HP:0002870)1.90775278
87Popliteal pterygium (HP:0009756)1.90616109
88Bronchomalacia (HP:0002780)1.90539136
89Pustule (HP:0200039)1.89161483
90Hyperhidrosis (HP:0000975)1.89099537
91Ulnar deviation of the wrist (HP:0003049)1.88920485
92Distal arthrogryposis (HP:0005684)1.88583173
93Unilateral renal agenesis (HP:0000122)1.85260531
94Abnormality of the dental pulp (HP:0006479)1.83884501
95Interstitial pulmonary disease (HP:0006530)1.81142443
96Pterygium (HP:0001059)1.80490959
97Focal segmental glomerulosclerosis (HP:0000097)1.80268289
98Carious teeth (HP:0000670)1.73034684
99Ankyloglossia (HP:0010296)1.71348490
100Seborrheic dermatitis (HP:0001051)1.71225970
101Esophageal atresia (HP:0002032)1.70924211
102Abnormality of the fingernails (HP:0001231)1.70851957
103Lack of skin elasticity (HP:0100679)1.69968579
104Duplicated collecting system (HP:0000081)1.68968840
105Achilles tendon contracture (HP:0001771)1.68765378
106Fine hair (HP:0002213)1.68472407
107Axonal loss (HP:0003447)1.68237216
108Sparse lateral eyebrow (HP:0005338)1.68226488
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.68158944
110Abnormality of the labia majora (HP:0012881)1.67411130
111Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.67071516
112Muscle fiber inclusion bodies (HP:0100299)1.66858752
113Muscle fiber splitting (HP:0003555)1.66854068
114Ureteral duplication (HP:0000073)1.64705497
115Hamartoma (HP:0010566)1.63519311
116Skin ulcer (HP:0200042)1.63502535
117Cerebral aneurysm (HP:0004944)1.63209661
118Aplasia involving bones of the extremities (HP:0009825)1.62880113
119Aplasia involving bones of the upper limbs (HP:0009823)1.62880113
120Aplasia of the phalanges of the hand (HP:0009802)1.62880113
121Congenital, generalized hypertrichosis (HP:0004540)1.61975150
122Neck muscle weakness (HP:0000467)1.59894965
123Abnormality of the distal phalanges of the toes (HP:0010182)1.58671479
124Nemaline bodies (HP:0003798)1.56822198
125Sudden death (HP:0001699)1.54967500
126Ureteral stenosis (HP:0000071)1.54133852
127Abnormality of the salivary glands (HP:0010286)1.52573009
128Hypergammaglobulinemia (HP:0010702)1.52255870
129Hypoplastic labia majora (HP:0000059)1.52093039
130Abnormality of the Achilles tendon (HP:0005109)1.52027180
131Premature rupture of membranes (HP:0001788)1.51749723
132Dry hair (HP:0011359)1.51031740
133Trismus (HP:0000211)1.50545302
134Absent eyelashes (HP:0000561)1.49710364
135Skin pits (HP:0100276)1.48748310
136Neonatal death (HP:0003811)1.48124835
137Distal lower limb amyotrophy (HP:0008944)1.46790434
138Exercise-induced myalgia (HP:0003738)1.45044230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.12570601
2MST1R4.02665823
3MAPKAPK33.83957412
4FER3.75436786
5MAP3K33.15134187
6MST42.87288144
7ERN12.85108653
8MAP3K22.83940925
9TRIB32.72043400
10EEF2K2.57007548
11RIPK12.50933207
12PIK3CG2.42785399
13LATS12.39063879
14EPHB22.38564786
15TTN2.18036045
16SMG12.05898054
17RPS6KB22.05440427
18TAOK11.95419319
19ICK1.92650459
20PTK61.91636649
21PKN21.64660911
22NME21.64233427
23MET1.62413768
24NME11.59159543
25IRAK31.51020374
26LRRK21.43392151
27MAP3K71.43388342
28MAP3K111.42216727
29MAP3K91.41667072
30MAP3K11.40815294
31EPHB11.40475631
32MAP2K61.28818051
33MAP3K101.28482129
34FGFR11.27299207
35PRKCI1.26380055
36FGFR41.22892735
37FRK1.17445078
38TRPM71.10852258
39PTK21.08580846
40TESK11.08398417
41PBK1.01970758
42DYRK1B1.00607343
43MAP2K30.95142091
44FGFR20.94885859
45MAP2K20.92155812
46RPS6KA40.86238962
47PDGFRA0.86083685
48EPHA30.84649945
49MAP3K60.84551035
50MATK0.83138147
51OBSCN0.83117229
52SIK10.81430960
53MAPK150.81005736
54STK100.80116239
55BMX0.76522448
56FGFR30.76187877
57WNK30.75847068
58CDK60.75829718
59STK240.75519375
60WNK40.75193261
61KSR20.74637169
62CAMK1D0.73721971
63MAPKAPK20.72982036
64MAP2K10.71832368
65PRKD30.71704402
66BCR0.65898404
67LMTK20.65569556
68DMPK0.64801288
69LATS20.63789935
70DDR20.63715306
71PIM20.62189893
72MUSK0.61173796
73RPS6KA10.61091506
74CDK70.59298309
75CHUK0.58893215
76STK38L0.58805685
77PAK40.55556052
78NEK60.54159824
79PRKD10.51730814
80STK380.50296822
81ERBB20.49800633
82NEK10.49661273
83ERBB30.48243412
84RET0.46698892
85PRPF4B0.44726046
86MTOR0.43780593
87GRK60.43754286
88PRKD20.40799734
89RPS6KC10.39229404
90RPS6KL10.39229404
91TGFBR10.37804696
92MAP2K40.37676790
93MARK20.37668328
94MAPKAPK50.36512806
95PRKAA20.35506192
96TGFBR20.34237650
97TYRO30.33933300
98PDPK10.31782080
99TYK20.31643316
100HIPK20.30930649
101STK30.30717075
102IRAK20.29460420
103PDGFRB0.29407408
104RPS6KA20.28554037
105PAK30.27645607
106MAPK80.27407805
107SCYL20.27391912
108MAP3K80.27386113
109ILK0.26944256
110RPS6KA60.26868367
111PHKG20.26378452
112PHKG10.26378452
113MAPK110.25886533
114NTRK20.25709159
115TBK10.25405480
116PAK20.25221044
117NTRK10.24536113
118SIK30.24393035
119CDK120.24095999
120WNK10.23662266
121OXSR10.23262071
122PRKG20.22720566
123SRC0.22459668
124CDC42BPA0.22313725
125CAMK1G0.22077955
126CDK80.22026920
127GSK3A0.21680527
128CDK90.21595195
129EPHA40.21131682
130STK110.19883347
131TNK20.19653406
132LIMK10.19065057
133DAPK10.18928320
134SGK30.16900818
135RPS6KB10.15747443
136PRKAA10.14115047
137AURKB0.13489664

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.72715621
2Fat digestion and absorption_Homo sapiens_hsa049752.67712474
3Linoleic acid metabolism_Homo sapiens_hsa005912.59070679
4Basal cell carcinoma_Homo sapiens_hsa052172.52060519
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20668955
6ECM-receptor interaction_Homo sapiens_hsa045122.12587752
7Protein digestion and absorption_Homo sapiens_hsa049742.06116367
8Phenylalanine metabolism_Homo sapiens_hsa003601.87515032
9Hedgehog signaling pathway_Homo sapiens_hsa043401.86520815
10Tight junction_Homo sapiens_hsa045301.81341711
11Arachidonic acid metabolism_Homo sapiens_hsa005901.76960093
12Fructose and mannose metabolism_Homo sapiens_hsa000511.73608439
13Adherens junction_Homo sapiens_hsa045201.72991815
14Histidine metabolism_Homo sapiens_hsa003401.68263610
15Fatty acid biosynthesis_Homo sapiens_hsa000611.67830432
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66389701
17Bladder cancer_Homo sapiens_hsa052191.62981187
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.60851424
19VEGF signaling pathway_Homo sapiens_hsa043701.57497464
20Mineral absorption_Homo sapiens_hsa049781.57003413
21Sphingolipid metabolism_Homo sapiens_hsa006001.56038271
22Other glycan degradation_Homo sapiens_hsa005111.53962794
23Hippo signaling pathway_Homo sapiens_hsa043901.51083876
24Proteoglycans in cancer_Homo sapiens_hsa052051.48521953
25Thyroid cancer_Homo sapiens_hsa052161.45298186
26Melanogenesis_Homo sapiens_hsa049161.34120114
27Pancreatic secretion_Homo sapiens_hsa049721.34063102
28Amoebiasis_Homo sapiens_hsa051461.30134172
29Gastric acid secretion_Homo sapiens_hsa049711.26352602
30Choline metabolism in cancer_Homo sapiens_hsa052311.24195134
31GnRH signaling pathway_Homo sapiens_hsa049121.23370827
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19662700
33Ether lipid metabolism_Homo sapiens_hsa005651.14291774
34Acute myeloid leukemia_Homo sapiens_hsa052211.14177544
35Focal adhesion_Homo sapiens_hsa045101.12459041
36Galactose metabolism_Homo sapiens_hsa000521.10150150
37Dorso-ventral axis formation_Homo sapiens_hsa043201.08086358
38Fatty acid elongation_Homo sapiens_hsa000621.06756047
39Inositol phosphate metabolism_Homo sapiens_hsa005621.06310170
40Endometrial cancer_Homo sapiens_hsa052131.00824849
41Notch signaling pathway_Homo sapiens_hsa043301.00754606
42AMPK signaling pathway_Homo sapiens_hsa041521.00589075
43Salivary secretion_Homo sapiens_hsa049701.00587264
44Caffeine metabolism_Homo sapiens_hsa002321.00360315
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.00303315
46Axon guidance_Homo sapiens_hsa043600.99260234
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.99141057
48Pancreatic cancer_Homo sapiens_hsa052120.97787263
49mTOR signaling pathway_Homo sapiens_hsa041500.96854831
50Toxoplasmosis_Homo sapiens_hsa051450.95425162
51Renin secretion_Homo sapiens_hsa049240.95379147
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93818002
53Renin-angiotensin system_Homo sapiens_hsa046140.93664523
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.93660487
55Small cell lung cancer_Homo sapiens_hsa052220.92141163
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91159267
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88924631
58Estrogen signaling pathway_Homo sapiens_hsa049150.88826839
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86848878
60Lysine degradation_Homo sapiens_hsa003100.86484441
61Vitamin digestion and absorption_Homo sapiens_hsa049770.86082963
62Insulin resistance_Homo sapiens_hsa049310.85731005
63Ovarian steroidogenesis_Homo sapiens_hsa049130.85666534
64Sulfur metabolism_Homo sapiens_hsa009200.85650815
65Arginine biosynthesis_Homo sapiens_hsa002200.85552829
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84716628
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84608942
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.83199343
69Renal cell carcinoma_Homo sapiens_hsa052110.81956037
70Pentose phosphate pathway_Homo sapiens_hsa000300.81403869
71Bile secretion_Homo sapiens_hsa049760.80626322
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79841153
73Tyrosine metabolism_Homo sapiens_hsa003500.79708068
74Wnt signaling pathway_Homo sapiens_hsa043100.79268258
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78587904
76MicroRNAs in cancer_Homo sapiens_hsa052060.77959572
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75959081
78beta-Alanine metabolism_Homo sapiens_hsa004100.73660979
79Glioma_Homo sapiens_hsa052140.72716314
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.72207515
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71900659
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71639391
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.68842527
84Platelet activation_Homo sapiens_hsa046110.65595168
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65552418
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65127642
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.64494369
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64473377
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64412748
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63006898
91Prostate cancer_Homo sapiens_hsa052150.62788261
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62758606
93Hepatitis C_Homo sapiens_hsa051600.62054761
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.61211614
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60803409
96Pathways in cancer_Homo sapiens_hsa052000.60796928
97Chemical carcinogenesis_Homo sapiens_hsa052040.60662239
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60241928
99Sulfur relay system_Homo sapiens_hsa041220.58891543
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.58717924
101Rap1 signaling pathway_Homo sapiens_hsa040150.58144065
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57078374
103Long-term depression_Homo sapiens_hsa047300.56519223
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55378917
105Non-small cell lung cancer_Homo sapiens_hsa052230.54079369
106ABC transporters_Homo sapiens_hsa020100.54037303
107Dilated cardiomyopathy_Homo sapiens_hsa054140.53183765
108ErbB signaling pathway_Homo sapiens_hsa040120.53104736
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.52792371
110Ras signaling pathway_Homo sapiens_hsa040140.51899368
111Vibrio cholerae infection_Homo sapiens_hsa051100.51450053
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51286063
113PPAR signaling pathway_Homo sapiens_hsa033200.50732558
114Prolactin signaling pathway_Homo sapiens_hsa049170.49860705
115Thyroid hormone synthesis_Homo sapiens_hsa049180.49667757
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49477086
117Circadian rhythm_Homo sapiens_hsa047100.49099115
118Insulin signaling pathway_Homo sapiens_hsa049100.49012424
119TGF-beta signaling pathway_Homo sapiens_hsa043500.48989929
120Chronic myeloid leukemia_Homo sapiens_hsa052200.48874400
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48507748
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48373785
123Arginine and proline metabolism_Homo sapiens_hsa003300.48063320
124p53 signaling pathway_Homo sapiens_hsa041150.47811453
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45896961
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44396233
127Salmonella infection_Homo sapiens_hsa051320.44177938
128Oxytocin signaling pathway_Homo sapiens_hsa049210.43167628
129Glucagon signaling pathway_Homo sapiens_hsa049220.41837571
130Endocytosis_Homo sapiens_hsa041440.39863727
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38986128
132Retinol metabolism_Homo sapiens_hsa008300.38943321

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