EVX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)8.66469585
2plasma membrane fusion (GO:0045026)8.04642723
3microtubule depolymerization (GO:0007019)7.99267159
4chromosome condensation (GO:0030261)7.86114951
5DNA packaging (GO:0006323)7.81266035
6response to pheromone (GO:0019236)7.67901794
7spermatid development (GO:0007286)7.65252539
8single strand break repair (GO:0000012)7.57016355
9somite rostral/caudal axis specification (GO:0032525)7.11128441
10microtubule polymerization or depolymerization (GO:0031109)7.09021756
11sperm-egg recognition (GO:0035036)6.92265254
12aminoglycoside antibiotic metabolic process (GO:0030647)6.85819885
13negative regulation of epidermis development (GO:0045683)6.69121489
14protein targeting to Golgi (GO:0000042)6.59225116
15spermatid nucleus differentiation (GO:0007289)6.58700368
16multicellular organism reproduction (GO:0032504)6.52481955
17maintenance of protein location in nucleus (GO:0051457)6.45317812
18regulation of mammary gland epithelial cell proliferation (GO:0033599)6.40824663
19regulation of response to osmotic stress (GO:0047484)6.35951554
20centriole replication (GO:0007099)6.35702015
21establishment of protein localization to Golgi (GO:0072600)6.29785709
22calcium ion-dependent exocytosis (GO:0017156)6.18098369
23binding of sperm to zona pellucida (GO:0007339)6.17002532
24negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.14086074
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.12669498
26protein localization to kinetochore (GO:0034501)6.11991614
27retrograde transport, vesicle recycling within Golgi (GO:0000301)6.07173265
28regulation of centriole replication (GO:0046599)6.01533488
29muscle organ morphogenesis (GO:0048644)5.87268354
30negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.85699650
31reproduction (GO:0000003)5.84491913
32spermatogenesis (GO:0007283)5.80601712
33male gamete generation (GO:0048232)5.78738851
34axonemal dynein complex assembly (GO:0070286)5.75887018
35phosphatidylethanolamine metabolic process (GO:0046337)5.67872183
36cell-cell recognition (GO:0009988)5.67780514
37negative regulation of cell cycle G2/M phase transition (GO:1902750)5.51609985
38regulation of nuclear cell cycle DNA replication (GO:0033262)5.48911187
39centriole assembly (GO:0098534)5.45509514
40regulation of telomere maintenance via telomerase (GO:0032210)5.40611539
41negative regulation of inclusion body assembly (GO:0090084)5.39449572
42histone H4-K5 acetylation (GO:0043981)5.36287798
43histone H4-K8 acetylation (GO:0043982)5.36287798
44gamete generation (GO:0007276)5.33497746
45histone H4-K12 acetylation (GO:0043983)5.31789349
46rRNA transcription (GO:0009303)5.28908570
47regulation of MHC class I biosynthetic process (GO:0045343)5.18712913
48notochord development (GO:0030903)5.17454304
49primitive streak formation (GO:0090009)5.16941203
50negative regulation of epidermal cell differentiation (GO:0045605)5.16398887
51negative regulation of telomerase activity (GO:0051974)5.16352681
52positive regulation of Rab GTPase activity (GO:0032851)5.10655008
53regulation of Rab GTPase activity (GO:0032313)5.10655008
54heterochromatin organization (GO:0070828)5.09123033
55mitotic sister chromatid segregation (GO:0000070)5.00251169
56sexual reproduction (GO:0019953)4.83481154
57cytidine metabolic process (GO:0046087)4.81890472
58cytidine catabolic process (GO:0006216)4.81890472
59cytidine deamination (GO:0009972)4.81890472
60cilium or flagellum-dependent cell motility (GO:0001539)4.74978146
61interferon-gamma production (GO:0032609)4.73638231
62cell wall macromolecule metabolic process (GO:0044036)4.66008395
63regulation of cilium movement (GO:0003352)4.64307416
64protein localization to Golgi apparatus (GO:0034067)4.63883509
65phenol-containing compound catabolic process (GO:0019336)4.58458407
66single fertilization (GO:0007338)4.54675433
67rRNA methylation (GO:0031167)4.53692862
68cell wall macromolecule catabolic process (GO:0016998)4.49380222
69hormone catabolic process (GO:0042447)4.48182596
70protein localization to chromosome, centromeric region (GO:0071459)4.46575993
71seminiferous tubule development (GO:0072520)4.43863803
72germ cell development (GO:0007281)4.43411248
73musculoskeletal movement (GO:0050881)4.37977256
74multicellular organismal movement (GO:0050879)4.37977256
75chromatin assembly (GO:0031497)4.36248256
76multicellular organismal reproductive process (GO:0048609)4.33714235
77positive regulation of DNA-dependent DNA replication (GO:2000105)4.33362144
78RNA destabilization (GO:0050779)4.27380965
79branching involved in mammary gland duct morphogenesis (GO:0060444)4.23072506
80DNA replication-dependent nucleosome assembly (GO:0006335)4.22235935
81DNA replication-dependent nucleosome organization (GO:0034723)4.22235935
82cellular process involved in reproduction in multicellular organism (GO:0022412)4.21870559
83response to dietary excess (GO:0002021)4.21656330
84cell migration involved in gastrulation (GO:0042074)4.19117343
85motile cilium assembly (GO:0044458)4.17481157
86sister chromatid segregation (GO:0000819)4.14349381
87rRNA modification (GO:0000154)4.14185672
88pre-miRNA processing (GO:0031054)4.13474259
89nuclear pore complex assembly (GO:0051292)4.12132775
90regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.09044025
91signal transduction involved in regulation of gene expression (GO:0023019)4.05724350
92nucleoside transmembrane transport (GO:1901642)4.04485960
93epithelial cilium movement (GO:0003351)4.01606871
94histone H4-K16 acetylation (GO:0043984)3.99678735
95regulation of inclusion body assembly (GO:0090083)3.97056817
96cellular ketone body metabolic process (GO:0046950)3.95994359
97coenzyme catabolic process (GO:0009109)3.94745783
98DNA replication checkpoint (GO:0000076)3.91757530
99organic cation transport (GO:0015695)3.91745378
100regulation of apoptotic process involved in morphogenesis (GO:1902337)3.91681332
101cerebral cortex neuron differentiation (GO:0021895)3.90650396
102fertilization (GO:0009566)3.87382885
103quinone metabolic process (GO:1901661)3.85023827
104Golgi to endosome transport (GO:0006895)3.82547284
105negative regulation of telomere maintenance (GO:0032205)3.77586281
106trophectodermal cell differentiation (GO:0001829)3.76842037
107regulation of translation in response to stress (GO:0043555)3.72791015
108nucleus organization (GO:0006997)3.69060386
109chromatin silencing (GO:0006342)3.68792975
110cell fate commitment involved in formation of primary germ layer (GO:0060795)3.67744566
111epoxygenase P450 pathway (GO:0019373)3.66621933
112regulation of gene silencing by RNA (GO:0060966)3.62463070
113regulation of posttranscriptional gene silencing (GO:0060147)3.62463070
114regulation of gene silencing by miRNA (GO:0060964)3.62463070
115nuclear pore organization (GO:0006999)3.61189235
116cilium movement (GO:0003341)3.58724832
117regulation of microtubule-based movement (GO:0060632)3.58536488
118negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.55238330
119intestinal epithelial cell development (GO:0060576)3.54669000
120maintenance of protein localization in organelle (GO:0072595)3.54133353
121bone trabecula formation (GO:0060346)3.51890951
122microtubule severing (GO:0051013)3.51768180
123anterior/posterior axis specification (GO:0009948)3.50236152
124regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.49434958
125regulation of somitogenesis (GO:0014807)3.48406590
126ketone body metabolic process (GO:1902224)3.47323098
127intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.46085726
128cellular modified amino acid catabolic process (GO:0042219)3.42703354
129transcription from mitochondrial promoter (GO:0006390)3.40674657
130mRNA stabilization (GO:0048255)3.40626496
131RNA stabilization (GO:0043489)3.40626496
132histone exchange (GO:0043486)3.38223971
133response to acidic pH (GO:0010447)3.35427667
134icosanoid secretion (GO:0032309)3.34383002
135arachidonic acid secretion (GO:0050482)3.34383002
136retinoic acid receptor signaling pathway (GO:0048384)3.32324410
137protein polyglutamylation (GO:0018095)3.32207380
138cardiovascular system development (GO:0072358)3.30341911
139vitamin A metabolic process (GO:0006776)3.29053221
140pyrimidine ribonucleoside catabolic process (GO:0046133)3.28387886
141regulation of mesoderm development (GO:2000380)3.27586938
142polyamine biosynthetic process (GO:0006596)3.24694015
143cullin deneddylation (GO:0010388)3.20769333
144proline transport (GO:0015824)3.20142960
145mitochondrion distribution (GO:0048311)3.19963961
146positive regulation of protein deacetylation (GO:0090312)3.19824504
147protein-DNA complex disassembly (GO:0032986)3.19581717
148nucleosome disassembly (GO:0006337)3.19581717
149cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.19509370
150tachykinin receptor signaling pathway (GO:0007217)3.19409494
151cellular response to pH (GO:0071467)3.19137927
152DNA damage response, detection of DNA damage (GO:0042769)3.18772510
153intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.17661832
154regulation of phosphoprotein phosphatase activity (GO:0043666)3.16967971
155regulation of telomere maintenance (GO:0032204)3.15386775
156ventricular system development (GO:0021591)3.15151857
157embryonic axis specification (GO:0000578)3.14798163
158regulation of telomerase activity (GO:0051972)3.14068699
159omega-hydroxylase P450 pathway (GO:0097267)3.09662928
160mitotic chromosome condensation (GO:0007076)3.09575145
161negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.07799510
162protein depolymerization (GO:0051261)3.06577356
163transepithelial transport (GO:0070633)3.06068045
164ribosome biogenesis (GO:0042254)3.04959880
165microtubule nucleation (GO:0007020)3.04317929
166negative regulation of interleukin-2 production (GO:0032703)3.04035323
167male meiosis (GO:0007140)2.98134796
168peptidyl-threonine dephosphorylation (GO:0035970)2.96724212
169multicellular organismal development (GO:0007275)2.95610810
170* regulation of transcription involved in cell fate commitment (GO:0060850)2.94480227
171cell recognition (GO:0008037)2.90322936
172glycerol ether metabolic process (GO:0006662)2.86736511
173negative regulation of Rho protein signal transduction (GO:0035024)2.86305755
174RNA localization (GO:0006403)2.84188015
175histone H3-K9 demethylation (GO:0033169)2.77002303
176homeostasis of number of cells within a tissue (GO:0048873)2.76828078
177male meiosis I (GO:0007141)2.70246589
178regulation of interleukin-13 production (GO:0032656)2.69207853
179ether metabolic process (GO:0018904)2.67485316
180genitalia morphogenesis (GO:0035112)2.66528804
181negative regulation of histone methylation (GO:0031061)2.66003919
182regulation of centrosome duplication (GO:0010824)2.61286827
183cranial nerve morphogenesis (GO:0021602)2.60704297
184positive regulation of action potential (GO:0045760)2.59548530
185spinal cord motor neuron differentiation (GO:0021522)2.58577799
186DNA conformation change (GO:0071103)2.57616884
187sperm motility (GO:0030317)11.2096260
188acrosome reaction (GO:0007340)10.9553219
189fusion of sperm to egg plasma membrane (GO:0007342)10.6476708
190daunorubicin metabolic process (GO:0044597)10.6234082
191polyketide metabolic process (GO:0030638)10.6234082
192doxorubicin metabolic process (GO:0044598)10.6234082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.57846419
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.57846419
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.57846419
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.32043070
5E2F7_22180533_ChIP-Seq_HELA_Human4.07582221
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.07445942
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.52493250
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.11273802
9* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.08384483
10EZH2_22144423_ChIP-Seq_EOC_Human3.01369308
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96437040
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86938498
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.86938498
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.84407387
15* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.81691614
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.80633200
17* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.60859525
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.59525329
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.59031061
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56651463
21* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.49973724
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.47174458
23FUS_26573619_Chip-Seq_HEK293_Human2.43889175
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.41952208
25CBP_20019798_ChIP-Seq_JUKART_Human2.41952208
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38085085
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29652221
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20255403
29* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.08173052
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.04663841
31* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04502688
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.02450529
33* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.02340185
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99826420
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97480071
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91167385
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91085333
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.90162657
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.88078740
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87726269
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.84215460
42ZNF274_21170338_ChIP-Seq_K562_Hela1.82055933
43* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81367722
44* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.80922702
45TAF15_26573619_Chip-Seq_HEK293_Human1.80833196
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.78728755
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76093802
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75504405
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.75355219
50IRF1_19129219_ChIP-ChIP_H3396_Human1.73874546
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.71061781
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70145409
53* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.68705996
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.67831023
55AR_21572438_ChIP-Seq_LNCaP_Human1.67731098
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.67383075
57ERA_21632823_ChIP-Seq_H3396_Human1.67015982
58P300_19829295_ChIP-Seq_ESCs_Human1.66717881
59* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65121140
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.63974729
61CTCF_27219007_Chip-Seq_Bcells_Human1.60227703
62DROSHA_22980978_ChIP-Seq_HELA_Human1.60040967
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58931414
64* NANOG_20526341_ChIP-Seq_ESCs_Human1.58774871
65ER_23166858_ChIP-Seq_MCF-7_Human1.58342748
66AR_25329375_ChIP-Seq_VCAP_Human1.58282658
67SMAD3_21741376_ChIP-Seq_ESCs_Human1.57525566
68RAC3_21632823_ChIP-Seq_H3396_Human1.57125773
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.56972539
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55836587
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.55009452
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53843660
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.51043691
74* CBX2_27304074_Chip-Seq_ESCs_Mouse1.50882389
75MYC_19829295_ChIP-Seq_ESCs_Human1.48334329
76* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.46816950
77* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46720797
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44614050
79SMAD4_21741376_ChIP-Seq_HESCs_Human1.43958648
80* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.42946919
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42919443
82* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.42322028
83* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41734383
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.41219146
85* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.41073564
86* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.41004883
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39928503
88* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38688121
89VDR_22108803_ChIP-Seq_LS180_Human1.38369605
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37117853
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35948766
92E2F1_17053090_ChIP-ChIP_MCF-7_Human1.34351607
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34269818
94OCT4_20526341_ChIP-Seq_ESCs_Human1.33650911
95TAF2_19829295_ChIP-Seq_ESCs_Human1.32615847
96MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32350353
97CBX2_22325352_ChIP-Seq_293T-Rex_Human1.31926460
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31207894
99RUNX2_22187159_ChIP-Seq_PCA_Human1.29533800
100RBPJ_21746931_ChIP-Seq_IB4_Human1.29174740
101* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28845761
102MYC_22102868_ChIP-Seq_BL_Human1.27929962
103ETV1_20927104_ChIP-Seq_GIST48_Human1.27630142
104* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27583459
105SOX2_18692474_ChIP-Seq_MESCs_Mouse1.27520018
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26728820
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.26567158
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26337972
109KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25988478
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25872886
111ERG_20517297_ChIP-Seq_VCAP_Human1.24678173
112TDRD3_21172665_ChIP-Seq_MCF-7_Human1.24668451
113NFYB_21822215_ChIP-Seq_K562_Human1.23200072
114HNFA_21074721_ChIP-Seq_CACO-2_Human1.23142594
115TCF4_18268006_ChIP-ChIP_LS174T_Human1.22818000
116* EZH2_27294783_Chip-Seq_ESCs_Mouse1.22607738
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22391677
118SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22140726
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21378607
120PHF8_20622854_ChIP-Seq_HELA_Human1.21276088
121TBL1_22424771_ChIP-Seq_293T_Human1.20958275
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20792043
123CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20406853
124NANOG_16518401_ChIP-PET_MESCs_Mouse1.18777477
125CTCF_20526341_ChIP-Seq_ESCs_Human1.18630286
126* EZH2_27304074_Chip-Seq_ESCs_Mouse1.18339221
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18059484
128GATA3_21878914_ChIP-Seq_MCF-7_Human1.17894963
129SMAD4_21799915_ChIP-Seq_A2780_Human1.17703855
130STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17146717
131STAT3_23295773_ChIP-Seq_U87_Human1.17100143
132SOX2_19829295_ChIP-Seq_ESCs_Human1.16194046
133NANOG_19829295_ChIP-Seq_ESCs_Human1.16194046
134BCL6_27268052_Chip-Seq_Bcells_Human1.15611118
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15013649
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.14966548
137TP53_18474530_ChIP-ChIP_U2OS_Human1.14665204
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13305842
139E2F1_20622854_ChIP-Seq_HELA_Human1.12540246
140GF1_26923725_Chip-Seq_HPCs_Mouse1.09817160
141REST_21632747_ChIP-Seq_MESCs_Mouse1.09430595
142MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08637698
143* NANOG_16153702_ChIP-ChIP_HESCs_Human1.08035112
144PRDM14_20953172_ChIP-Seq_ESCs_Human1.07214737
145BCOR_27268052_Chip-Seq_Bcells_Human1.07089965
146NFYA_21822215_ChIP-Seq_K562_Human1.06854568
147EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06775352
148TP53_22127205_ChIP-Seq_IMR90_Human1.06539237
149P300_27268052_Chip-Seq_Bcells_Human1.06218098
150FOXH1_21741376_ChIP-Seq_ESCs_Human1.05865551
151PHF8_20622853_ChIP-Seq_HELA_Human1.05661989
152P68_20966046_ChIP-Seq_HELA_Human1.03677506
153P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.02271907
154PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01832707
155OCT1_27270436_Chip-Seq_PROSTATE_Human1.00323657
156P53_21459846_ChIP-Seq_SAOS-2_Human0.99922763
157SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99690534
158NCOR1_26117541_ChIP-Seq_K562_Human0.97655540
159* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97126384
160KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94264533
161TCF7_22412390_ChIP-Seq_EML_Mouse0.93360554
162EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92329274
163* NANOG_21062744_ChIP-ChIP_HESCs_Human0.91709932
164* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90804916
165TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89466706
166CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88560628
167TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88257819
168* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83825027
169* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82257716
170TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82046954
171KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.81626815
172KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79292168
173RACK7_27058665_Chip-Seq_MCF-7_Human0.78365295
174SMC4_20622854_ChIP-Seq_HELA_Human0.78335046
175WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77711416
176KDM2B_26808549_Chip-Seq_K562_Human0.76737457
177RING1B_27294783_Chip-Seq_NPCs_Mouse0.76602703
178SOX2_16153702_ChIP-ChIP_HESCs_Human0.76101433
179YY1_22570637_ChIP-Seq_MALME-3M_Human0.75741473
180KAP1_27257070_Chip-Seq_ESCs_Mouse0.75381803
181* ELK3_25401928_ChIP-Seq_HUVEC_Human0.75212762
182CTCF_21964334_Chip-Seq_Bcells_Human0.73198073
183FOXO3_23340844_ChIP-Seq_DLD1_Human0.72902251
184SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71892354
185SRY_22984422_ChIP-ChIP_TESTIS_Rat0.69984666
186KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.69564065
187RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.69289231
188STAT3_18555785_ChIP-Seq_MESCs_Mouse0.69117626
189PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67898272
190E2F1_18555785_ChIP-Seq_MESCs_Mouse0.67788218
191* TP53_20018659_ChIP-ChIP_R1E_Mouse0.67707794
192LXR_22292898_ChIP-Seq_THP-1_Human0.66864190
193ELF1_20517297_ChIP-Seq_JURKAT_Human0.66383055
194AR_21909140_ChIP-Seq_LNCAP_Human0.65454735
195SCL_19346495_ChIP-Seq_HPC-7_Human0.65087469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.64982836
2MP0003878_abnormal_ear_physiology4.64982836
3MP0006292_abnormal_olfactory_placode4.38873644
4MP0003011_delayed_dark_adaptation4.32311351
5MP0005670_abnormal_white_adipose4.30813095
6MP0003698_abnormal_male_reproductive4.23351593
7MP0003890_abnormal_embryonic-extraembry4.23236373
8MP0004264_abnormal_extraembryonic_tissu4.16599376
9MP0002254_reproductive_system_inflammat4.09979719
10MP0001929_abnormal_gametogenesis3.62815155
11MP0005394_taste/olfaction_phenotype3.55913294
12MP0005499_abnormal_olfactory_system3.55913294
13MP0004858_abnormal_nervous_system3.26619752
14MP0003122_maternal_imprinting3.21555493
15MP0002822_catalepsy3.11860956
16MP0008057_abnormal_DNA_replication2.97323559
17MP0002332_abnormal_exercise_endurance2.72139276
18MP0005075_abnormal_melanosome_morpholog2.69586796
19MP0005257_abnormal_intraocular_pressure2.61867186
20MP0002653_abnormal_ependyma_morphology2.59999159
21MP0003121_genomic_imprinting2.48515599
22MP0002161_abnormal_fertility/fecundity2.43740890
23MP0003705_abnormal_hypodermis_morpholog2.29702981
24MP0010030_abnormal_orbit_morphology2.28716764
25MP0000678_abnormal_parathyroid_gland2.22655875
26MP0010352_gastrointestinal_tract_polyps2.21075630
27* MP0004957_abnormal_blastocyst_morpholog2.18161168
28MP0003718_maternal_effect2.13532114
29MP0001485_abnormal_pinna_reflex2.10578753
30MP0005423_abnormal_somatic_nervous2.09696834
31MP0005410_abnormal_fertilization10.7906928
32MP0006035_abnormal_mitochondrial_morpho1.98875052
33MP0005380_embryogenesis_phenotype1.93497913
34MP0001672_abnormal_embryogenesis/_devel1.93497913
35MP0003123_paternal_imprinting1.92295501
36MP0002210_abnormal_sex_determination1.90938610
37MP0003938_abnormal_ear_development1.90484026
38MP0002932_abnormal_joint_morphology1.80200870
39MP0002234_abnormal_pharynx_morphology1.76956450
40MP0002277_abnormal_respiratory_mucosa1.76365272
41MP0002088_abnormal_embryonic_growth/wei1.75914772
42MP0003984_embryonic_growth_retardation1.73645218
43MP0001293_anophthalmia1.70683361
44MP0002735_abnormal_chemical_nociception1.65529443
45MP0002127_abnormal_cardiovascular_syste1.64188290
46MP0000762_abnormal_tongue_morphology1.61911479
47MP0000534_abnormal_ureter_morphology1.56130675
48MP0000049_abnormal_middle_ear1.55784274
49MP0001849_ear_inflammation1.55031534
50MP0001486_abnormal_startle_reflex1.54975716
51MP0008961_abnormal_basal_metabolism1.54306807
52MP0001145_abnormal_male_reproductive1.51249279
53MP0003183_abnormal_peptide_metabolism1.50599099
54MP0000653_abnormal_sex_gland1.49059030
55MP0000516_abnormal_urinary_system1.46651127
56MP0005367_renal/urinary_system_phenotyp1.46651127
57MP0008789_abnormal_olfactory_epithelium1.41658644
58MP0002092_abnormal_eye_morphology1.40971086
59MP0004742_abnormal_vestibular_system1.40860861
60MP0002282_abnormal_trachea_morphology1.40327461
61MP0000350_abnormal_cell_proliferation1.40274227
62MP0009053_abnormal_anal_canal1.38813112
63MP0003077_abnormal_cell_cycle1.37881679
64MP0006082_CNS_inflammation1.36913424
65MP0003880_abnormal_central_pattern1.36465091
66* MP0002085_abnormal_embryonic_tissue1.34843835
67MP0002233_abnormal_nose_morphology1.33618140
68MP0004859_abnormal_synaptic_plasticity1.31410493
69MP0002084_abnormal_developmental_patter1.30615973
70MP0003119_abnormal_digestive_system1.29622393
71MP0009697_abnormal_copulation1.26661222
72* MP0002086_abnormal_extraembryonic_tissu1.26586579
73MP0001348_abnormal_lacrimal_gland1.26575610
74MP0002114_abnormal_axial_skeleton1.26292832
75MP0003315_abnormal_perineum_morphology1.25641097
76MP0001968_abnormal_touch/_nociception1.25175321
77MP0005379_endocrine/exocrine_gland_phen1.24239948
78MP0001963_abnormal_hearing_physiology1.22107395
79MP0000428_abnormal_craniofacial_morphol1.21203974
80MP0000026_abnormal_inner_ear1.20555019
81MP0005266_abnormal_metabolism1.18497784
82MP0003935_abnormal_craniofacial_develop1.17788565
83MP0003646_muscle_fatigue1.17481861
84MP0000432_abnormal_head_morphology1.15667919
85MP0004043_abnormal_pH_regulation1.15364617
86MP0004133_heterotaxia1.14955830
87MP0003755_abnormal_palate_morphology1.14402056
88MP0008995_early_reproductive_senescence1.09890019
89MP0003111_abnormal_nucleus_morphology1.09442771
90MP0003937_abnormal_limbs/digits/tail_de1.08780750
91MP0005551_abnormal_eye_electrophysiolog1.06823646
92MP0005248_abnormal_Harderian_gland1.03476174
93MP0004197_abnormal_fetal_growth/weight/1.03166615
94MP0001730_embryonic_growth_arrest1.00803976
95MP0008932_abnormal_embryonic_tissue0.99837268
96MP0003283_abnormal_digestive_organ0.97994663
97MP0001697_abnormal_embryo_size0.97389166
98MP0001529_abnormal_vocalization0.97327076
99MP0002734_abnormal_mechanical_nocicepti0.96808236
100MP0001905_abnormal_dopamine_level0.94129422
101MP0002970_abnormal_white_adipose0.93514017
102MP0004085_abnormal_heartbeat0.93482146
103MP0008770_decreased_survivor_rate0.93210421
104MP0005310_abnormal_salivary_gland0.92358040
105MP0005391_vision/eye_phenotype0.91886915
106MP0002396_abnormal_hematopoietic_system0.91523797
107MP0002067_abnormal_sensory_capabilities0.91430014
108MP0003137_abnormal_impulse_conducting0.90924500
109MP0002116_abnormal_craniofacial_bone0.90900041
110MP0010094_abnormal_chromosome_stability0.90497340
111MP0005253_abnormal_eye_physiology0.89401603
112MP0002925_abnormal_cardiovascular_devel0.88874986
113MP0002249_abnormal_larynx_morphology0.88731238
114MP0005508_abnormal_skeleton_morphology0.86185307
115MP0002111_abnormal_tail_morphology0.83029554
116MP0000313_abnormal_cell_death0.82762730
117MP0001984_abnormal_olfaction0.82671862
118MP0002132_abnormal_respiratory_system0.82010131
119MP0008877_abnormal_DNA_methylation0.81985384
120MP0002557_abnormal_social/conspecific_i0.81312361
121* MP0002080_prenatal_lethality0.80633269
122MP0005451_abnormal_body_composition0.78879430
123MP0003879_abnormal_hair_cell0.78850684
124MP0002229_neurodegeneration0.78560680
125MP0002138_abnormal_hepatobiliary_system0.77337362
126MP0004381_abnormal_hair_follicle0.76929195
127MP0000490_abnormal_crypts_of0.76524756
128MP0002098_abnormal_vibrissa_morphology0.75768619
129MP0002751_abnormal_autonomic_nervous0.75251955
130MP0001765_abnormal_ion_homeostasis0.75117456
131MP0005395_other_phenotype0.75092575
132MP0009703_decreased_birth_body0.74274747
133* MP0000955_abnormal_spinal_cord0.73545805
134MP0008569_lethality_at_weaning0.71274947
135MP0009745_abnormal_behavioral_response0.71001606
136MP0005187_abnormal_penis_morphology0.69806560
137MP0002572_abnormal_emotion/affect_behav0.69438391
138MP0002272_abnormal_nervous_system0.69310313
139MP0001286_abnormal_eye_development0.68472639
140MP0003861_abnormal_nervous_system0.67551122
141MP0002269_muscular_atrophy0.67456707
142MP0001440_abnormal_grooming_behavior0.66306269
143MP0003787_abnormal_imprinting0.66300047
144MP0005666_abnormal_adipose_tissue0.65866479
145MP0002081_perinatal_lethality0.65038069
146MP0002733_abnormal_thermal_nociception0.63652279
147MP0001188_hyperpigmentation0.62694106
148MP0003635_abnormal_synaptic_transmissio0.62478196
149MP0003942_abnormal_urinary_system0.62083279
150MP0001970_abnormal_pain_threshold0.61485140
151MP0008007_abnormal_cellular_replicative0.61353219
152MP0005083_abnormal_biliary_tract0.60712625
153MP0005023_abnormal_wound_healing0.60658884
154MP0001879_abnormal_lymphatic_vessel0.60248337
155MP0000778_abnormal_nervous_system0.60179501
156MP0008004_abnormal_stomach_pH0.59459698
157MP0002928_abnormal_bile_duct0.58428443
158MP0002736_abnormal_nociception_after0.58351940
159MP0003693_abnormal_embryo_hatching0.57512857
160MP0001666_abnormal_nutrient_absorption0.56962906
161MP0000750_abnormal_muscle_regeneration0.56886988
162MP0003385_abnormal_body_wall0.56745779
163MP0002882_abnormal_neuron_morphology0.56024366
164MP0002109_abnormal_limb_morphology0.55742483
165MP0005623_abnormal_meninges_morphology0.55722551
166MP0004510_myositis0.55604631
167MP0002184_abnormal_innervation0.55337637
168MP0009250_abnormal_appendicular_skeleto0.54391054
169MP0003936_abnormal_reproductive_system0.54341452
170MP0006072_abnormal_retinal_apoptosis0.54093419
171MP0000631_abnormal_neuroendocrine_gland0.53097959
172MP0000163_abnormal_cartilage_morphology0.52834841
173MP0000358_abnormal_cell_content/0.52502451
174MP0000749_muscle_degeneration0.51835568
175MP0002697_abnormal_eye_size0.50169028

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.41718264
2Severe visual impairment (HP:0001141)7.13548787
3Hypochromic microcytic anemia (HP:0004840)5.78110605
4Rib fusion (HP:0000902)5.40554179
5Dynein arm defect of respiratory motile cilia (HP:0012255)5.40004946
6Absent/shortened dynein arms (HP:0200106)5.40004946
7Hepatoblastoma (HP:0002884)5.28419950
8Multiple enchondromatosis (HP:0005701)4.97440992
9Tubulointerstitial nephritis (HP:0001970)4.87755029
10Asymmetric septal hypertrophy (HP:0001670)4.82547075
11Abnormality of the lower motor neuron (HP:0002366)4.77021188
12Bony spicule pigmentary retinopathy (HP:0007737)4.58423972
13Chronic hepatic failure (HP:0100626)4.40752963
14Bell-shaped thorax (HP:0001591)4.39053487
15Resting tremor (HP:0002322)4.32351311
16Abnormal ciliary motility (HP:0012262)4.29589946
17Attenuation of retinal blood vessels (HP:0007843)4.25184106
18Abnormal respiratory motile cilium physiology (HP:0012261)4.24147574
19Ependymoma (HP:0002888)4.08840524
20Male infertility (HP:0003251)4.08762748
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.01561993
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.97636740
23Abnormal respiratory epithelium morphology (HP:0012253)3.93924080
24Abnormal respiratory motile cilium morphology (HP:0005938)3.93924080
25Rectal fistula (HP:0100590)3.84340425
26Rectovaginal fistula (HP:0000143)3.84340425
27Abnormality of macular pigmentation (HP:0008002)3.80598085
28Infertility (HP:0000789)3.73852279
29Hyperkalemia (HP:0002153)3.70462374
30Enlarged epiphyses (HP:0010580)3.68745992
31Partial duplication of thumb phalanx (HP:0009944)3.67342949
32Neoplasm of striated muscle (HP:0009728)3.67299309
33Bifid tongue (HP:0010297)3.62769818
34Hypoplastic ischia (HP:0003175)3.57588717
35Nephroblastoma (Wilms tumor) (HP:0002667)3.56975401
36Aplasia/Hypoplasia of the earlobes (HP:0009906)3.54999444
37Facial shape deformation (HP:0011334)3.47507137
38Potter facies (HP:0002009)3.47507137
39Rhabdomyosarcoma (HP:0002859)3.44955490
40Intestinal fistula (HP:0100819)3.44769055
41Fused cervical vertebrae (HP:0002949)3.40567780
42Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37895140
43Nephronophthisis (HP:0000090)3.37342106
44Vaginal fistula (HP:0004320)3.33528586
45Abnormality of the ischium (HP:0003174)3.32969206
46Aplasia/hypoplasia of the humerus (HP:0006507)3.32526362
47Embryonal renal neoplasm (HP:0011794)3.32017376
48Short humerus (HP:0005792)3.31592470
49Partial duplication of the phalanx of hand (HP:0009999)3.29570912
50Aplasia/Hypoplasia of the fovea (HP:0008060)3.25669439
51Hypoplasia of the fovea (HP:0007750)3.25669439
52Cone-rod dystrophy (HP:0000548)3.24066327
53Testicular atrophy (HP:0000029)3.23301023
54Anomalous pulmonary venous return (HP:0010772)3.12973627
55Congenital malformation of the right heart (HP:0011723)3.07921725
56Double outlet right ventricle (HP:0001719)3.07921725
57Abnormal rod and cone electroretinograms (HP:0008323)3.04057734
58Abnormal lung lobation (HP:0002101)3.00976792
59Nasal polyposis (HP:0100582)2.97677393
60Abnormal spermatogenesis (HP:0008669)2.96170995
61Astrocytoma (HP:0009592)2.95107173
62Abnormality of the astrocytes (HP:0100707)2.95107173
63Postural instability (HP:0002172)2.94853104
64Abnormality of the salivary glands (HP:0010286)2.94243963
65Amyotrophic lateral sclerosis (HP:0007354)2.89000913
66Chromsome breakage (HP:0040012)2.87207148
67Hypoplasia of the thymus (HP:0000778)2.82728123
68Ragged-red muscle fibers (HP:0003200)2.81015690
69Periauricular skin pits (HP:0100277)2.80762913
70Preauricular pit (HP:0004467)2.80762913
71Preauricular skin tag (HP:0000384)2.80195314
72Progressive sensorineural hearing impairment (HP:0000408)2.79653613
73Abnormality of the phalanges of the hallux (HP:0010057)2.79148409
74Abnormality of the aortic arch (HP:0012303)2.78827077
75Generalized aminoaciduria (HP:0002909)2.77539158
76Hyperinsulinemic hypoglycemia (HP:0000825)2.76394937
77Trismus (HP:0000211)2.74657519
78Abnormality of the renal medulla (HP:0100957)2.74147062
79Abnormality of the pulmonary veins (HP:0011718)2.70291767
80Azoospermia (HP:0000027)2.69969688
81Hypoalphalipoproteinemia (HP:0003233)2.68776671
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.67587475
83Rhinitis (HP:0012384)2.66814455
84Amelogenesis imperfecta (HP:0000705)2.65867464
85Shawl scrotum (HP:0000049)2.65727716
86Abdominal situs inversus (HP:0003363)2.65718043
87Abnormality of abdominal situs (HP:0011620)2.65718043
88Abnormal cartilage morphology (HP:0002763)2.64774726
89Short 5th finger (HP:0009237)2.60903640
90Abnormal urine output (HP:0012590)2.59354006
91Horizontal nystagmus (HP:0000666)2.55374548
92Abnormality of the distal phalanx of the thumb (HP:0009617)2.54495465
93Generalized hypotonia (HP:0001290)2.52387336
94Renal duplication (HP:0000075)2.50281516
95Skin tags (HP:0010609)2.49468489
96Abnormal connection of the cardiac segments (HP:0011545)2.48417111
97Abnormal ventriculo-arterial connection (HP:0011563)2.48417111
98Transposition of the great arteries (HP:0001669)2.48417111
99Large earlobe (HP:0009748)2.46354578
100Abnormality of the parathyroid morphology (HP:0011766)2.44516646
101Abnormality of the fovea (HP:0000493)2.43588074
102Abnormality of potassium homeostasis (HP:0011042)2.43162826
103Abnormality of the pubic bones (HP:0003172)2.42394897
104Tubulointerstitial abnormality (HP:0001969)2.38890178
105Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.38460026
106Renal dysplasia (HP:0000110)2.38388389
107Abnormality of the costochondral junction (HP:0000919)2.38189712
108Portal hypertension (HP:0001409)2.37231234
109Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35055270
110Progressive cerebellar ataxia (HP:0002073)2.34385381
111Sensory axonal neuropathy (HP:0003390)2.33565303
112Abnormal drinking behavior (HP:0030082)2.33150143
113Polydipsia (HP:0001959)2.33150143
114Supernumerary spleens (HP:0009799)2.32524579
115Abnormality of the nasal mucosa (HP:0000433)2.32083480
116Hypochromic anemia (HP:0001931)2.31857708
117Epiphyseal dysplasia (HP:0002656)2.31014569
118Truncal obesity (HP:0001956)2.29791570
119Nasolacrimal duct obstruction (HP:0000579)2.26082647
120Pendular nystagmus (HP:0012043)2.26019744
121Impulsivity (HP:0100710)2.25670629
122Meckel diverticulum (HP:0002245)2.25334638
123Abnormality of chromosome segregation (HP:0002916)2.25261695
124Hyperventilation (HP:0002883)2.24912498
125Insulin-resistant diabetes mellitus (HP:0000831)2.24911513
126Hypopigmentation of the fundus (HP:0007894)2.24383497
127Skin pits (HP:0100276)2.23273134
128Abnormality of renal excretion (HP:0011036)2.21486426
129Stage 5 chronic kidney disease (HP:0003774)2.19748125
130Widely patent fontanelles and sutures (HP:0004492)2.19636441
131Unilateral renal agenesis (HP:0000122)2.19545391
132Vertebral fusion (HP:0002948)2.19040421
133Reduced antithrombin III activity (HP:0001976)2.18085302
134Abnormality of the hepatic vasculature (HP:0006707)2.17821750
135Aplasia/Hypoplasia of the uvula (HP:0010293)2.17813542
136Tongue fasciculations (HP:0001308)2.17509361
137Neoplasm of the heart (HP:0100544)2.15866533
138Progressive muscle weakness (HP:0003323)2.15740933
139Abnormality of the ileum (HP:0001549)2.13610335
140Mixed hearing impairment (HP:0000410)2.11467917
141Pseudobulbar signs (HP:0002200)2.11384798
142Optic nerve hypoplasia (HP:0000609)2.11245231
143Aplasia/Hypoplasia of the macula (HP:0008059)2.11196960
144Polyuria (HP:0000103)2.10797981
145Abnormality of the musculature of the hand (HP:0001421)2.10755998
146Abnormality of dental color (HP:0011073)2.10727392
147Glioma (HP:0009733)2.10553184
148Preaxial foot polydactyly (HP:0001841)2.08307288
149Renal Fanconi syndrome (HP:0001994)2.08006441
150Microretrognathia (HP:0000308)2.07404022
151Tetraplegia (HP:0002445)2.07145545
152Absent epiphyses (HP:0010577)2.07062841
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.07062841
154Hypoplastic scapulae (HP:0000882)2.05777290
155Aplasia/Hypoplasia of the scapulae (HP:0006713)2.05777290
156Upper motor neuron abnormality (HP:0002127)2.04580383
157Aplasia/Hypoplasia of the sternum (HP:0006714)2.04278765
158Duplication of thumb phalanx (HP:0009942)2.03494709
159Increased connective tissue (HP:0009025)2.02971873
160Difficulty running (HP:0009046)2.01965670
161Abnormality of small intestinal villus morphology (HP:0011472)2.01889302
162Villous atrophy (HP:0011473)2.01889302
163Intellectual disability, moderate (HP:0002342)2.01453331
164Prominent occiput (HP:0000269)1.99013759
165Concave nail (HP:0001598)1.97894448
166Muscle fibrillation (HP:0010546)1.97336228
167Malignant neoplasm of the central nervous system (HP:0100836)1.96658818
168Chronic bronchitis (HP:0004469)1.96200489
169Menstrual irregularities (HP:0000858)1.95482422
170Glossoptosis (HP:0000162)1.93490473
171Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93343769
172Premature ovarian failure (HP:0008209)1.92106811
173Short ribs (HP:0000773)1.92069744
174Atresia of the external auditory canal (HP:0000413)1.91474853
175Missing ribs (HP:0000921)1.90794670
176Malnutrition (HP:0004395)1.90419984
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89222797
178Recurrent corneal erosions (HP:0000495)1.88291408
179Aplasia/Hypoplasia affecting the retina (HP:0008061)1.88268014
180Hand muscle atrophy (HP:0009130)1.87623012
181Renovascular hypertension (HP:0100817)1.87432785
182Hypophosphatemic rickets (HP:0004912)1.87175848
183Facial cleft (HP:0002006)1.86367465
184Progressive hearing impairment (HP:0001730)1.84888545
185Progressive external ophthalmoplegia (HP:0000590)1.84681676
186Hyperuricemia (HP:0002149)1.82874453
187Increased purine levels (HP:0004368)1.82874453
188Osteomalacia (HP:0002749)1.78125399
189Omphalocele (HP:0001539)1.78051756
190Myokymia (HP:0002411)1.77997249
191Hyponatremia (HP:0002902)1.75741697
192Abnormality of urine glucose concentration (HP:0011016)1.75168324
193Glycosuria (HP:0003076)1.75168324
194Ventricular tachycardia (HP:0004756)1.74099641
195Spastic paraparesis (HP:0002313)1.70712426
196Failure to thrive in infancy (HP:0001531)1.69238411
197Hypokalemia (HP:0002900)1.68698693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.81672136
2CDK128.50789794
3GRK55.56403804
4TESK14.92545318
5GRK64.66568081
6PNCK4.53228794
7ERN14.27606900
8GRK13.40164066
9ADRBK23.39549068
10INSRR3.06090277
11PLK22.96248640
12CSF1R2.81182946
13TYRO32.71490086
14TNIK2.56265622
15BRD42.55181601
16CAMK1G2.54509224
17TTK2.52799072
18TGFBR22.46546496
19MOS2.36596364
20GRK72.29584434
21PRKD32.29096273
22STK102.26335049
23STK38L2.24030283
24MATK2.22278822
25MAPK152.20124795
26MAPK72.14903808
27MAP4K21.99912083
28WNK11.87321319
29CDK71.58916083
30MST1R1.54261575
31CAMK41.45061939
32NTRK11.43574173
33MARK11.41021645
34LATS21.40322864
35PRKG21.38226150
36MAP3K101.37485959
37EPHA21.33077829
38MARK21.25705861
39BRAF1.21173620
40PAK41.19922418
41ADRBK11.16798652
42AKT31.15371388
43PIK3CG1.14654043
44CHEK21.12569789
45MKNK21.10897473
46PLK11.07421693
47MAP2K41.05689191
48BMPR1B1.05335932
49HIPK21.05204076
50ACVR1B0.96647582
51PDPK10.95271550
52PDK10.93262938
53ALK0.91227231
54FGFR30.87928562
55TRIM280.86397570
56PINK10.85714657
57SIK20.83026102
58NEK60.82506219
59CAMK1D0.82237988
60WNK40.82186010
61STK390.81923960
62AKT20.81305492
63MAP3K40.80453471
64ZAK0.79657357
65CDK30.79117168
66CHEK10.75388389
67MAP2K60.70006239
68CDC70.69794090
69CSK0.68686934
70WNK30.68232431
71PRKG10.64729844
72MAP3K70.63817398
73OXSR10.63460319
74PTK2B0.62310712
75CASK0.62010643
76MTOR0.59779238
77KSR20.59770556
78MAP3K110.57152376
79MAPK120.56496719
80RPS6KA20.55272906
81NEK20.54193234
82MAP3K90.53239786
83UHMK10.52118520
84SGK2230.51764502
85SGK4940.51764502
86EIF2AK20.51412260
87RPS6KA10.49182686
88ICK0.49049767
89PDGFRA0.48253011
90CDK20.46742440
91ROCK10.46043922
92PTK20.45389009
93MAP2K70.43521747
94AURKA0.42738287
95BMX0.42360337
96IGF1R0.40582204
97RPS6KB20.40253750
98PRKCI0.39995054
99CDK40.38706728
100MAP2K20.36536426
101PRKD20.36484770
102ERBB20.36135663
103BUB10.35876412
104MKNK10.35435470
105ITK0.35253850
106CSNK1E0.34019500
107LATS10.33764227
108ATM0.33137733
109MINK10.32263616
110DDR20.31654952
111PAK10.31587813
112AURKB0.31495101
113CAMK10.30826722
114PRKAA20.30811945
115SGK20.30613153
116TSSK60.30336658
117RIPK10.28911691
118PRKCD0.27741581
119MAPK80.27066073
120PRKCB0.26818709
121NTRK30.26746966
122MAPK100.26553256
123CDK10.25896188
124NLK0.25244601
125DYRK20.24970895
126STK380.24861850
127BRSK20.24295443
128DAPK20.23456910
129SGK10.22730894
130NTRK20.21800740
131BRSK10.21765254
132INSR0.21590413
133MAPK10.20762471
134GSK3B0.20378461
135PRKCE0.20033951
136WEE10.19944326
137MAP3K20.18690295
138MAPK140.18543184
139CDK150.18481398
140GSK3A0.18414546
141RPS6KC10.18370128
142RPS6KL10.18370128
143PRKCZ0.18295668
144IKBKB0.18045649
145RPS6KA60.17536475
146MAPK130.17518466
147PASK0.16991392
148CDK190.16729132
149DYRK1A0.16486305
150CDK11A0.16070257
151DYRK30.15677203
152CDK80.15621920
153PRKACG0.15568842
154PRKACB0.14867917
155CDK180.14478290
156TAOK10.13757498
157PRKAA10.13264157
158TESK20.13153609
159TGFBR10.12837944
160DYRK1B0.12457082
161MAP3K80.11643140
162MAPK40.11617559
163PRKCG0.09125322
164RPS6KA30.09074022
165AKT10.08521900
166SIK10.08112011
167SRPK10.07164645
168PRKACA0.07105375
169CDK140.07007370
170CHUK0.06391658
171NEK10.05693788

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.61791820
2Vitamin B6 metabolism_Homo sapiens_hsa007506.58728952
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.47836822
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.10413421
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.20826628
6Fructose and mannose metabolism_Homo sapiens_hsa000513.68681657
7Olfactory transduction_Homo sapiens_hsa047403.57659300
8Galactose metabolism_Homo sapiens_hsa000522.54234117
9Arachidonic acid metabolism_Homo sapiens_hsa005902.54178036
10Linoleic acid metabolism_Homo sapiens_hsa005912.25971356
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.22462766
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.12978602
13Butanoate metabolism_Homo sapiens_hsa006502.07661247
14Nicotine addiction_Homo sapiens_hsa050331.93744774
15RNA transport_Homo sapiens_hsa030131.88945271
16Thyroid cancer_Homo sapiens_hsa052161.78523340
17mTOR signaling pathway_Homo sapiens_hsa041501.76393768
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76014565
19Fatty acid metabolism_Homo sapiens_hsa012121.65303097
20mRNA surveillance pathway_Homo sapiens_hsa030151.61549997
21Fatty acid degradation_Homo sapiens_hsa000711.58327116
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55094581
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52645782
24Basal cell carcinoma_Homo sapiens_hsa052171.48592084
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47217661
26Synaptic vesicle cycle_Homo sapiens_hsa047211.37864488
27Type II diabetes mellitus_Homo sapiens_hsa049301.36934623
28Fanconi anemia pathway_Homo sapiens_hsa034601.33327608
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32766321
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32496625
31Hedgehog signaling pathway_Homo sapiens_hsa043401.32340779
32Selenocompound metabolism_Homo sapiens_hsa004501.30185099
33Cell cycle_Homo sapiens_hsa041101.28146753
34Ovarian steroidogenesis_Homo sapiens_hsa049131.27879125
35Phototransduction_Homo sapiens_hsa047441.24982374
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24311523
37One carbon pool by folate_Homo sapiens_hsa006701.23498135
38Morphine addiction_Homo sapiens_hsa050321.21934641
39Phenylalanine metabolism_Homo sapiens_hsa003601.17999418
40Cardiac muscle contraction_Homo sapiens_hsa042601.17994398
41Nitrogen metabolism_Homo sapiens_hsa009101.14698321
42DNA replication_Homo sapiens_hsa030301.14055248
43RNA degradation_Homo sapiens_hsa030181.13919870
44Protein digestion and absorption_Homo sapiens_hsa049741.13397384
45Hippo signaling pathway_Homo sapiens_hsa043901.06953391
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06675528
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06524829
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05886694
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05681590
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04596958
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02632901
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00559156
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.00308725
54Circadian entrainment_Homo sapiens_hsa047130.99965886
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.98540435
56Mismatch repair_Homo sapiens_hsa034300.98298397
57Ether lipid metabolism_Homo sapiens_hsa005650.97950010
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97166026
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95980328
60Fat digestion and absorption_Homo sapiens_hsa049750.95072044
61MicroRNAs in cancer_Homo sapiens_hsa052060.94334878
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.91948054
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91255283
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89933263
65Spliceosome_Homo sapiens_hsa030400.89623448
66Pathways in cancer_Homo sapiens_hsa052000.89269702
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89006974
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.88104426
69Chemical carcinogenesis_Homo sapiens_hsa052040.88061639
70Huntingtons disease_Homo sapiens_hsa050160.87339403
71Glutamatergic synapse_Homo sapiens_hsa047240.87188645
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.86974678
73Homologous recombination_Homo sapiens_hsa034400.85017747
74Inositol phosphate metabolism_Homo sapiens_hsa005620.84679579
75Calcium signaling pathway_Homo sapiens_hsa040200.82165016
76Serotonergic synapse_Homo sapiens_hsa047260.81686887
77PPAR signaling pathway_Homo sapiens_hsa033200.79657673
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79425936
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.79051751
80p53 signaling pathway_Homo sapiens_hsa041150.78338265
81Rap1 signaling pathway_Homo sapiens_hsa040150.77841502
82Choline metabolism in cancer_Homo sapiens_hsa052310.76777021
83GABAergic synapse_Homo sapiens_hsa047270.76558580
84cAMP signaling pathway_Homo sapiens_hsa040240.75838801
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75782180
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75335170
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73533815
88Gastric acid secretion_Homo sapiens_hsa049710.72403763
89Salivary secretion_Homo sapiens_hsa049700.72342782
90Base excision repair_Homo sapiens_hsa034100.72215722
91Arginine biosynthesis_Homo sapiens_hsa002200.72199278
92Glycerolipid metabolism_Homo sapiens_hsa005610.71619773
93Arginine and proline metabolism_Homo sapiens_hsa003300.71121661
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71057480
95Bladder cancer_Homo sapiens_hsa052190.69745465
96Wnt signaling pathway_Homo sapiens_hsa043100.69360279
97Endocytosis_Homo sapiens_hsa041440.68140218
98Cholinergic synapse_Homo sapiens_hsa047250.66593527
99Estrogen signaling pathway_Homo sapiens_hsa049150.65794331
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64993082
101Purine metabolism_Homo sapiens_hsa002300.64489812
102Renin-angiotensin system_Homo sapiens_hsa046140.64231645
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63970178
104Notch signaling pathway_Homo sapiens_hsa043300.63420050
105Tyrosine metabolism_Homo sapiens_hsa003500.63050740
106Ribosome_Homo sapiens_hsa030100.61176057
107Propanoate metabolism_Homo sapiens_hsa006400.59630858
108Non-small cell lung cancer_Homo sapiens_hsa052230.59302945
109Other glycan degradation_Homo sapiens_hsa005110.58304670
110Acute myeloid leukemia_Homo sapiens_hsa052210.57913773
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57554560
112Sulfur relay system_Homo sapiens_hsa041220.56042389
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.54778756
114Proteoglycans in cancer_Homo sapiens_hsa052050.54683990
115Adherens junction_Homo sapiens_hsa045200.53639397
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.53294196
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51729587
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51670649
119MAPK signaling pathway_Homo sapiens_hsa040100.51248880
120Folate biosynthesis_Homo sapiens_hsa007900.51006903
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50998123
122Tight junction_Homo sapiens_hsa045300.50924896
123Tryptophan metabolism_Homo sapiens_hsa003800.50738179
124Pentose phosphate pathway_Homo sapiens_hsa000300.49605009
125Basal transcription factors_Homo sapiens_hsa030220.49335954
126Caffeine metabolism_Homo sapiens_hsa002320.49333252
127African trypanosomiasis_Homo sapiens_hsa051430.47178991
128VEGF signaling pathway_Homo sapiens_hsa043700.47178548
129Bile secretion_Homo sapiens_hsa049760.45733519
130Insulin secretion_Homo sapiens_hsa049110.44755254
131ABC transporters_Homo sapiens_hsa020100.43856548
132Pancreatic secretion_Homo sapiens_hsa049720.43176488
133Herpes simplex infection_Homo sapiens_hsa051680.42895975
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42441672
135Gap junction_Homo sapiens_hsa045400.41741933
136RNA polymerase_Homo sapiens_hsa030200.41695355
137Biosynthesis of amino acids_Homo sapiens_hsa012300.41134525
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41036872
139AMPK signaling pathway_Homo sapiens_hsa041520.40023575
140Renin secretion_Homo sapiens_hsa049240.39207274
141Alcoholism_Homo sapiens_hsa050340.38906813
142Ras signaling pathway_Homo sapiens_hsa040140.38583495
143Oxytocin signaling pathway_Homo sapiens_hsa049210.37309295
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35288312
145Viral myocarditis_Homo sapiens_hsa054160.34812718
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34158839
147Taste transduction_Homo sapiens_hsa047420.33967647
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.32905333
149Colorectal cancer_Homo sapiens_hsa052100.32586467
150Pancreatic cancer_Homo sapiens_hsa052120.31820456
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.31761674
152Antigen processing and presentation_Homo sapiens_hsa046120.31732373
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31316395
154Carbon metabolism_Homo sapiens_hsa012000.30859082
155Complement and coagulation cascades_Homo sapiens_hsa046100.30699889
156HTLV-I infection_Homo sapiens_hsa051660.30633276
157Metabolic pathways_Homo sapiens_hsa011000.30173497
158Type I diabetes mellitus_Homo sapiens_hsa049400.29930071
159Apoptosis_Homo sapiens_hsa042100.29383918
160GnRH signaling pathway_Homo sapiens_hsa049120.29366741
161Prolactin signaling pathway_Homo sapiens_hsa049170.28240302
162Melanogenesis_Homo sapiens_hsa049160.28234333
163Long-term depression_Homo sapiens_hsa047300.26763586
164Retinol metabolism_Homo sapiens_hsa008300.24594145
165Sphingolipid signaling pathway_Homo sapiens_hsa040710.23307178
166TGF-beta signaling pathway_Homo sapiens_hsa043500.22268327
167Oocyte meiosis_Homo sapiens_hsa041140.20777463
168Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19896779
169Dorso-ventral axis formation_Homo sapiens_hsa043200.19832245
170Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19534349

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