EWSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.57821793
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.75917340
3positive regulation of gamma-delta T cell activation (GO:0046645)4.35334027
4negative regulation of RNA splicing (GO:0033119)4.31379269
5protein localization to kinetochore (GO:0034501)4.29404672
6nuclear pore organization (GO:0006999)4.28342737
7nuclear pore complex assembly (GO:0051292)4.20463782
8negative regulation of mRNA processing (GO:0050686)4.01401663
9mitotic sister chromatid cohesion (GO:0007064)3.99921339
10mitotic nuclear envelope disassembly (GO:0007077)3.93559329
11DNA strand elongation involved in DNA replication (GO:0006271)3.92280663
12tolerance induction (GO:0002507)3.90561703
13pre-miRNA processing (GO:0031054)3.89288189
14dosage compensation (GO:0007549)3.88749096
15Golgi transport vesicle coating (GO:0048200)3.85614226
16COPI coating of Golgi vesicle (GO:0048205)3.85614226
17DNA duplex unwinding (GO:0032508)3.84461929
18DNA replication-dependent nucleosome assembly (GO:0006335)3.82024912
19DNA replication-dependent nucleosome organization (GO:0034723)3.82024912
20DNA geometric change (GO:0032392)3.81898627
21regulation of gamma-delta T cell differentiation (GO:0045586)3.76807219
22negative regulation of histone methylation (GO:0031061)3.76182961
23DNA strand elongation (GO:0022616)3.73323662
24translesion synthesis (GO:0019985)3.71432436
25sister chromatid segregation (GO:0000819)3.70529651
26nuclear envelope disassembly (GO:0051081)3.70328773
27membrane disassembly (GO:0030397)3.70328773
28negative regulation of mRNA metabolic process (GO:1903312)3.69288968
29protein localization to chromosome, centromeric region (GO:0071459)3.68867465
30mitotic chromosome condensation (GO:0007076)3.65194078
31DNA replication initiation (GO:0006270)3.63318892
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.60106676
33peptidyl-lysine dimethylation (GO:0018027)3.53847167
34regulation of histone H3-K9 methylation (GO:0051570)3.50549383
35folic acid-containing compound biosynthetic process (GO:0009396)3.49434338
36histone arginine methylation (GO:0034969)3.49166473
37nuclear envelope reassembly (GO:0031468)3.45310020
38mitotic nuclear envelope reassembly (GO:0007084)3.45310020
39mitotic sister chromatid segregation (GO:0000070)3.44402601
40heterochromatin organization (GO:0070828)3.42693192
41regulation of translational fidelity (GO:0006450)3.39347986
42IMP biosynthetic process (GO:0006188)3.37756479
43mRNA stabilization (GO:0048255)3.32442079
44RNA stabilization (GO:0043489)3.32442079
45alternative mRNA splicing, via spliceosome (GO:0000380)3.30796445
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29416919
47telomere maintenance via semi-conservative replication (GO:0032201)3.27968625
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.23160837
49regulation of gamma-delta T cell activation (GO:0046643)3.22968008
50mRNA splicing, via spliceosome (GO:0000398)3.16734399
51RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.16734399
52DNA conformation change (GO:0071103)3.14360881
53pore complex assembly (GO:0046931)3.12484901
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.11030469
55RNA splicing, via transesterification reactions (GO:0000375)3.10983137
56regulation of RNA export from nucleus (GO:0046831)3.10946951
57intracellular estrogen receptor signaling pathway (GO:0030520)3.10619570
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10603131
59regulation of sister chromatid cohesion (GO:0007063)3.09543999
60negative regulation of erythrocyte differentiation (GO:0045647)3.09087387
61peptidyl-arginine omega-N-methylation (GO:0035247)3.08151511
62postreplication repair (GO:0006301)3.07371506
63DNA topological change (GO:0006265)3.04540373
64chromatin assembly (GO:0031497)3.04101493
65mitotic recombination (GO:0006312)3.03347932
66viral mRNA export from host cell nucleus (GO:0046784)3.02560783
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02437877
68protein-DNA complex disassembly (GO:0032986)3.01554139
69nucleosome disassembly (GO:0006337)3.01554139
70establishment of viral latency (GO:0019043)3.01206131
71chromatin assembly or disassembly (GO:0006333)3.00674063
72regulation of translational termination (GO:0006449)3.00585780
73glucocorticoid receptor signaling pathway (GO:0042921)2.99263567
74Peyers patch development (GO:0048541)2.98681023
75mucosal-associated lymphoid tissue development (GO:0048537)2.98681023
76nuclear envelope organization (GO:0006998)2.96523684
77histone H2A acetylation (GO:0043968)2.95931491
78regulation of DNA damage checkpoint (GO:2000001)2.95501398
79positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.95457338
80mitotic G1 DNA damage checkpoint (GO:0031571)2.93397439
81regulation of histone H3-K27 methylation (GO:0061085)2.92039177
82positive regulation of receptor biosynthetic process (GO:0010870)2.91627935
83termination of RNA polymerase II transcription (GO:0006369)2.90906494
84regulation of spindle organization (GO:0090224)2.90361095
85telomere maintenance via recombination (GO:0000722)2.89632166
86regulation of RNA stability (GO:0043487)2.86640072
873-UTR-mediated mRNA stabilization (GO:0070935)2.85382155
88mRNA transport (GO:0051028)2.85224430
89cellular hyperosmotic response (GO:0071474)2.85222415
90IMP metabolic process (GO:0046040)2.83977395
91ATP-dependent chromatin remodeling (GO:0043044)2.82751882
92RNA export from nucleus (GO:0006405)2.82441881
93regulation of chromosome segregation (GO:0051983)2.81587163
94negative regulation of gene expression, epigenetic (GO:0045814)2.81550784
95positive regulation of chromosome segregation (GO:0051984)2.81549314
96positive regulation of RNA splicing (GO:0033120)2.81539012
97proline biosynthetic process (GO:0006561)2.81095586
98DNA replication checkpoint (GO:0000076)2.80708141
99formation of translation preinitiation complex (GO:0001731)2.78674424
100regulation of mRNA stability (GO:0043488)2.78324498
101mRNA export from nucleus (GO:0006406)2.78108156
102chromosome condensation (GO:0030261)2.77826513
103regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76865075
104peptidyl-arginine N-methylation (GO:0035246)2.75960314
105peptidyl-arginine methylation (GO:0018216)2.75960314
106protein localization to chromosome (GO:0034502)2.75680178
107regulation of defense response to virus by virus (GO:0050690)2.75533080
108mRNA splice site selection (GO:0006376)2.75489184
109establishment of integrated proviral latency (GO:0075713)2.75439269
110V(D)J recombination (GO:0033151)2.74936554
111gene silencing by RNA (GO:0031047)2.73983719
112regulation of nucleobase-containing compound transport (GO:0032239)2.73834322
113gene silencing (GO:0016458)2.72158763
114negative regulation of chromosome segregation (GO:0051985)2.71520592
115actin filament depolymerization (GO:0030042)2.71270275
116DNA ligation (GO:0006266)2.70910835
117spindle assembly checkpoint (GO:0071173)2.69943572
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69208938
119nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.69135331
120mitotic spindle assembly checkpoint (GO:0007094)2.68274176
121DNA replication-independent nucleosome assembly (GO:0006336)2.67433771
122DNA replication-independent nucleosome organization (GO:0034724)2.67433771
123telomere maintenance via telomere lengthening (GO:0010833)2.66172006
124regulation of mitotic spindle organization (GO:0060236)2.66084713
125negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65721661
126negative regulation of sister chromatid segregation (GO:0033046)2.65721661
127negative regulation of mitotic sister chromatid separation (GO:2000816)2.65721661
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65721661
129mitotic metaphase plate congression (GO:0007080)2.64160691
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.64053865
131protein export from nucleus (GO:0006611)2.63347616
132regulation of centriole replication (GO:0046599)2.62969650
133negative regulation of B cell apoptotic process (GO:0002903)2.61727323
134rRNA transcription (GO:0009303)2.60851551
135cellular response to interleukin-4 (GO:0071353)2.59377366
136negative regulation of DNA repair (GO:0045738)2.56886485
137nuclear export (GO:0051168)2.56557713
138cellular response to virus (GO:0098586)2.54196890
139trophectodermal cell differentiation (GO:0001829)2.53251210
140positive regulation of B cell differentiation (GO:0045579)2.53170438
141poly(A)+ mRNA export from nucleus (GO:0016973)2.52462562
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51002441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.57189536
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.17861635
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57725384
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.57374232
5MYC_22102868_ChIP-Seq_BL_Human3.41318657
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32561340
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.23598956
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91580865
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55459678
10CIITA_25753668_ChIP-Seq_RAJI_Human2.34087798
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30048437
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19261284
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.14875063
14VDR_21846776_ChIP-Seq_THP-1_Human2.13310076
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09933379
16XRN2_22483619_ChIP-Seq_HELA_Human2.09229491
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05360101
18AR_21909140_ChIP-Seq_LNCAP_Human1.93938721
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91301646
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86998525
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.67598871
22TCF7_22412390_ChIP-Seq_EML_Mouse1.63200049
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61280109
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.60048203
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59764038
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59020926
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57551614
28* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56991077
29* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56245676
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55758589
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55452422
32KDM5A_27292631_Chip-Seq_BREAST_Human1.53732668
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.43690095
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42434213
35KDM2B_26808549_Chip-Seq_DND41_Human1.42005411
36UTX_26944678_Chip-Seq_JUKART_Human1.41009630
37* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41002026
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40868697
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40726676
40* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40385373
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39568878
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39492111
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39204105
44TTF2_22483619_ChIP-Seq_HELA_Human1.37380493
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35641063
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35524686
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34760494
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34165229
49GABP_19822575_ChIP-Seq_HepG2_Human1.32868696
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.31926458
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31031617
52VDR_23849224_ChIP-Seq_CD4+_Human1.30725656
53* FOXP3_21729870_ChIP-Seq_TREG_Human1.29947963
54LXR_22292898_ChIP-Seq_THP-1_Human1.29659250
55MAF_26560356_Chip-Seq_TH1_Human1.26506745
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25823208
57ZNF263_19887448_ChIP-Seq_K562_Human1.25390521
58* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24296070
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21087019
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21025093
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.20729637
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20261061
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18728270
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18341015
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17816216
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.17479525
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17434876
68DCP1A_22483619_ChIP-Seq_HELA_Human1.15067985
69TFEB_21752829_ChIP-Seq_HELA_Human1.13975844
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13657869
71* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12714291
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12489500
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12471662
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11897954
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10892558
76* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10346499
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10332483
78SPI1_23547873_ChIP-Seq_NB4_Human1.10185339
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09618919
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08978686
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.08195189
82RACK7_27058665_Chip-Seq_MCF-7_Human1.06356064
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04578202
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04477649
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04445260
86P68_20966046_ChIP-Seq_HELA_Human1.04338752
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03648481
88SCL_19346495_ChIP-Seq_HPC-7_Human1.03371765
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02957613
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.02688074
91CHD1_26751641_Chip-Seq_LNCaP_Human1.02631962
92* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02390161
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02369199
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02068314
95CLOCK_20551151_ChIP-Seq_293T_Human1.01785953
96* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01727678
97* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01721862
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01017416
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00374874
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00232618
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99994196
102MYB_26560356_Chip-Seq_TH1_Human0.99556061
103VDR_24763502_ChIP-Seq_THP-1_Human0.99427403
104* NCOR1_26117541_ChIP-Seq_K562_Human0.99279808
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99266568
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97688790
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97205031
108CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96970853
109MYB_26560356_Chip-Seq_TH2_Human0.96180623
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95939623
111* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94933147
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94235342
113* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93295562
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92772669
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92503693
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90253424
117SALL1_21062744_ChIP-ChIP_HESCs_Human0.89292758
118RUNX1_22412390_ChIP-Seq_EML_Mouse0.89183215
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88982605
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88634336
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88282171
122MAF_26560356_Chip-Seq_TH2_Human0.86905548
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86471076
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.85981688
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85647018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.64830646
2MP0003693_abnormal_embryo_hatching3.48484343
3* MP0003111_abnormal_nucleus_morphology3.44526709
4MP0003077_abnormal_cell_cycle3.15657454
5MP0004957_abnormal_blastocyst_morpholog3.06565953
6MP0010352_gastrointestinal_tract_polyps2.84507941
7MP0002009_preneoplasia2.74414706
8MP0008057_abnormal_DNA_replication2.71546235
9MP0003123_paternal_imprinting2.60281727
10MP0005076_abnormal_cell_differentiation2.56983212
11MP0001730_embryonic_growth_arrest2.31854430
12MP0002396_abnormal_hematopoietic_system2.27692733
13MP0010307_abnormal_tumor_latency2.22717526
14MP0000350_abnormal_cell_proliferation2.22328407
15MP0004808_abnormal_hematopoietic_stem2.12425696
16MP0000537_abnormal_urethra_morphology2.01383113
17MP0003705_abnormal_hypodermis_morpholog2.00675157
18MP0008058_abnormal_DNA_repair2.00571496
19MP0005075_abnormal_melanosome_morpholog1.99953793
20MP0004197_abnormal_fetal_growth/weight/1.92253705
21* MP0008007_abnormal_cellular_replicative1.90723103
22MP0003121_genomic_imprinting1.88337290
23MP0005451_abnormal_body_composition1.88122724
24MP0009278_abnormal_bone_marrow1.85694199
25MP0008260_abnormal_autophagy1.85069957
26MP0002084_abnormal_developmental_patter1.83964040
27MP0005380_embryogenesis_phenotype1.80769953
28MP0001672_abnormal_embryogenesis/_devel1.80769953
29MP0001697_abnormal_embryo_size1.78583681
30MP0002085_abnormal_embryonic_tissue1.76714514
31MP0008877_abnormal_DNA_methylation1.75975822
32MP0008932_abnormal_embryonic_tissue1.74615119
33MP0010030_abnormal_orbit_morphology1.73267413
34MP0003984_embryonic_growth_retardation1.70910401
35MP0002088_abnormal_embryonic_growth/wei1.69713306
36MP0005058_abnormal_lysosome_morphology1.68586812
37MP0002080_prenatal_lethality1.67945044
38MP0006054_spinal_hemorrhage1.67862566
39MP0003436_decreased_susceptibility_to1.60610391
40MP0002086_abnormal_extraembryonic_tissu1.60203292
41MP0002653_abnormal_ependyma_morphology1.56440440
42MP0003567_abnormal_fetal_cardiomyocyte1.50123814
43* MP0000703_abnormal_thymus_morphology1.46707237
44MP0003172_abnormal_lysosome_physiology1.46486296
45MP0000490_abnormal_crypts_of1.44686116
46MP0002006_tumorigenesis1.44380609
47MP0001293_anophthalmia1.43776657
48MP0000428_abnormal_craniofacial_morphol1.42276815
49MP0001849_ear_inflammation1.39679946
50MP0001835_abnormal_antigen_presentation1.39054484
51MP0000733_abnormal_muscle_development1.33934028
52MP0001800_abnormal_humoral_immune1.32936607
53MP0009053_abnormal_anal_canal1.32757170
54MP0005000_abnormal_immune_tolerance1.31892372
55MP0003221_abnormal_cardiomyocyte_apopto1.29473000
56MP0003763_abnormal_thymus_physiology1.28475429
57* MP0000313_abnormal_cell_death1.28357234
58* MP0000716_abnormal_immune_system1.26046723
59MP0003300_gastrointestinal_ulcer1.25192074
60MP0000569_abnormal_digit_pigmentation1.25033175
61MP0001819_abnormal_immune_cell1.22894494
62MP0002420_abnormal_adaptive_immunity1.22729352
63MP0001545_abnormal_hematopoietic_system1.22630850
64MP0005397_hematopoietic_system_phenotyp1.22630850
65MP0003119_abnormal_digestive_system1.20593030
66MP0003566_abnormal_cell_adhesion1.20350881
67MP0009672_abnormal_birth_weight1.20294129
68MP0005408_hypopigmentation1.18700770
69MP0004947_skin_inflammation1.17358965
70* MP0002019_abnormal_tumor_incidence1.17097064
71MP0003115_abnormal_respiratory_system1.16297403
72MP0003890_abnormal_embryonic-extraembry1.15682036
73* MP0002398_abnormal_bone_marrow1.14347872
74MP0006035_abnormal_mitochondrial_morpho1.13327926
75MP0002452_abnormal_antigen_presenting1.12445443
76MP0003283_abnormal_digestive_organ1.11658935
77MP0005671_abnormal_response_to1.11321355
78MP0002092_abnormal_eye_morphology1.11153019
79MP0009703_decreased_birth_body1.08585256
80MP0005464_abnormal_platelet_physiology1.08292276
81MP0001915_intracranial_hemorrhage1.07280934
82MP0002723_abnormal_immune_serum1.06954335
83MP0008961_abnormal_basal_metabolism1.04686185
84MP0003787_abnormal_imprinting1.03190091
85MP0000465_gastrointestinal_hemorrhage1.03171817
86MP0005025_abnormal_response_to1.02650783
87MP0004185_abnormal_adipocyte_glucose1.01657621
88MP0001873_stomach_inflammation1.01197074
89MP0003935_abnormal_craniofacial_develop0.99817883
90* MP0002722_abnormal_immune_system0.98572068
91MP0002925_abnormal_cardiovascular_devel0.98286685
92MP0010234_abnormal_vibrissa_follicle0.97954450
93MP0000566_synostosis0.97465853
94MP0001853_heart_inflammation0.96797866
95MP0003786_premature_aging0.96446278
96MP0002697_abnormal_eye_size0.96178459
97MP0004233_abnormal_muscle_weight0.93974941
98MP0002405_respiratory_system_inflammati0.90005151
99MP0009697_abnormal_copulation0.89989363
100* MP0002210_abnormal_sex_determination0.89498240
101MP0004858_abnormal_nervous_system0.89034801
102MP0003866_abnormal_defecation0.89019006
103MP0003122_maternal_imprinting0.88501938
104MP0001727_abnormal_embryo_implantation0.88443555
105MP0005023_abnormal_wound_healing0.88387558
106MP0004782_abnormal_surfactant_physiolog0.87504106
107MP0002089_abnormal_postnatal_growth/wei0.87055940
108MP0000358_abnormal_cell_content/0.86866297
109MP0002111_abnormal_tail_morphology0.86790895
110MP0003861_abnormal_nervous_system0.85784101
111* MP0000689_abnormal_spleen_morphology0.84424921
112MP0008770_decreased_survivor_rate0.83788730
113* MP0001145_abnormal_male_reproductive0.83594759
114MP0005621_abnormal_cell_physiology0.82339409
115MP0005501_abnormal_skin_physiology0.82321880
116MP0005384_cellular_phenotype0.81236610
117MP0005187_abnormal_penis_morphology0.80992120
118MP0000003_abnormal_adipose_tissue0.78784340
119MP0010155_abnormal_intestine_physiology0.78762500
120MP0002877_abnormal_melanocyte_morpholog0.78600944
121MP0000371_diluted_coat_color0.78309387
122MP0009333_abnormal_splenocyte_physiolog0.78016444
123MP0000266_abnormal_heart_morphology0.77540548
124MP0003942_abnormal_urinary_system0.76964372
125MP0002932_abnormal_joint_morphology0.76952124
126* MP0002429_abnormal_blood_cell0.76080851
127MP0000477_abnormal_intestine_morphology0.76071366
128MP0003937_abnormal_limbs/digits/tail_de0.74186990
129MP0000432_abnormal_head_morphology0.73531768
130MP0004264_abnormal_extraembryonic_tissu0.71978074
131MP0003303_peritoneal_inflammation0.71638559
132MP0000858_altered_metastatic_potential0.69435533
133MP0002234_abnormal_pharynx_morphology0.69383238
134* MP0001929_abnormal_gametogenesis0.69226595
135MP0000685_abnormal_immune_system0.67760678
136MP0002166_altered_tumor_susceptibility0.66983637
137MP0002075_abnormal_coat/hair_pigmentati0.66490011
138MP0001784_abnormal_fluid_regulation0.66383518
139MP0002116_abnormal_craniofacial_bone0.65917326

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)5.31356482
2IgM deficiency (HP:0002850)5.05534325
3Abnormality of B cell number (HP:0010975)4.74888116
4Ragged-red muscle fibers (HP:0003200)3.87519024
5Hyperacusis (HP:0010780)3.74293569
6Ependymoma (HP:0002888)3.71219423
7Short 4th metacarpal (HP:0010044)3.66648585
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.66648585
9Increased nuchal translucency (HP:0010880)3.27269464
10Microvesicular hepatic steatosis (HP:0001414)3.26973764
11IgA deficiency (HP:0002720)3.23786238
12Selective tooth agenesis (HP:0001592)3.13514489
13Renal duplication (HP:0000075)3.02562105
14Medulloblastoma (HP:0002885)2.98120800
15IgG deficiency (HP:0004315)2.96237265
16Colon cancer (HP:0003003)2.88337531
17Volvulus (HP:0002580)2.84148687
18Broad distal phalanx of finger (HP:0009836)2.82673455
19Abnormality of the astrocytes (HP:0100707)2.81208062
20Astrocytoma (HP:0009592)2.81208062
21Gastrointestinal stroma tumor (HP:0100723)2.76796516
22Abnormality of the 4th metacarpal (HP:0010012)2.75403966
23Progressive muscle weakness (HP:0003323)2.71491134
24Elfin facies (HP:0004428)2.67003473
25Abnormality of the fingertips (HP:0001211)2.62225546
26Renovascular hypertension (HP:0100817)2.60779029
27Combined immunodeficiency (HP:0005387)2.60381150
28Abnormality of T cell physiology (HP:0011840)2.60130740
29Lymphopenia (HP:0001888)2.54664428
30Severe combined immunodeficiency (HP:0004430)2.53532503
31Proximal placement of thumb (HP:0009623)2.53337798
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.53206079
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.51544802
34Basal cell carcinoma (HP:0002671)2.51509790
35Recurrent viral infections (HP:0004429)2.50524479
36Increased IgE level (HP:0003212)2.48557543
37Deviation of the thumb (HP:0009603)2.42931779
38Overriding aorta (HP:0002623)2.40222536
39Long palpebral fissure (HP:0000637)2.38839944
40Long eyelashes (HP:0000527)2.36869465
41High pitched voice (HP:0001620)2.36153395
42Deep palmar crease (HP:0006191)2.36124458
43Neoplasm of the oral cavity (HP:0100649)2.36121523
44Glioma (HP:0009733)2.35907124
45Progressive external ophthalmoplegia (HP:0000590)2.33626574
46Abnormal number of incisors (HP:0011064)2.32533077
47Cerebral aneurysm (HP:0004944)2.31658587
48Insomnia (HP:0100785)2.30774927
49Bowel diverticulosis (HP:0005222)2.30595109
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28597581
51Prominent nose (HP:0000448)2.27481787
52Granulocytopenia (HP:0001913)2.22486655
53Recurrent sinusitis (HP:0011108)2.21841520
54Trigonocephaly (HP:0000243)2.21382223
55Broad palm (HP:0001169)2.20396975
56Pointed chin (HP:0000307)2.19144562
57Neoplasm of striated muscle (HP:0009728)2.16252816
58Urethral obstruction (HP:0000796)2.15525669
59Increased density of long bones (HP:0006392)2.12718506
60Skin tags (HP:0010609)2.12356216
61Lymphoma (HP:0002665)2.10711466
62High anterior hairline (HP:0009890)2.08693067
63Chromsome breakage (HP:0040012)2.08243703
64Shallow orbits (HP:0000586)2.07917366
65Pelvic girdle muscle weakness (HP:0003749)2.07526140
66Heterotopia (HP:0002282)2.05151271
67Obsessive-compulsive behavior (HP:0000722)2.04945662
68Autoimmune hemolytic anemia (HP:0001890)2.03758647
69Rhabdomyosarcoma (HP:0002859)2.02964840
70Aplasia/Hypoplasia of the thymus (HP:0010515)2.01193428
71Reticulocytopenia (HP:0001896)2.01040238
72Malignant gastrointestinal tract tumors (HP:0006749)2.00419979
73Gastrointestinal carcinoma (HP:0002672)2.00419979
74Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.00078164
75Abnormality of T cells (HP:0002843)1.99935572
76Seborrheic dermatitis (HP:0001051)1.99031551
77Patellar aplasia (HP:0006443)1.97070359
78Broad face (HP:0000283)1.96215283
79Atresia of the external auditory canal (HP:0000413)1.95392892
80Colitis (HP:0002583)1.95315969
81Pseudobulbar signs (HP:0002200)1.95167482
82Bicuspid aortic valve (HP:0001647)1.94305320
83Abnormality of the anterior horn cell (HP:0006802)1.93780967
84Degeneration of anterior horn cells (HP:0002398)1.93780967
85Overlapping toe (HP:0001845)1.92861317
86Missing ribs (HP:0000921)1.91765809
87Back pain (HP:0003418)1.89451938
88Autoimmune thrombocytopenia (HP:0001973)1.88968118
89Cellulitis (HP:0100658)1.86802528
90Preauricular skin tag (HP:0000384)1.86455822
91Flat cornea (HP:0007720)1.86024946
92Gastrointestinal inflammation (HP:0004386)1.85399837
93Aplasia/Hypoplasia of the patella (HP:0006498)1.85076870
94Broad thumb (HP:0011304)1.84295213
95Megalocornea (HP:0000485)1.82334512
96Cafe-au-lait spot (HP:0000957)1.82333243
97Panhypogammaglobulinemia (HP:0003139)1.81906496
98Viral hepatitis (HP:0006562)1.80403205
99Amaurosis fugax (HP:0100576)1.80205346
100Cutis marmorata (HP:0000965)1.79528927
101Elevated erythrocyte sedimentation rate (HP:0003565)1.79518957
102Skull defect (HP:0001362)1.78938492
103Abnormality of the calcaneus (HP:0008364)1.78451135
104Abnormality of the lower motor neuron (HP:0002366)1.77948257
105Abnormality of the columella (HP:0009929)1.77513763
106Shoulder girdle muscle weakness (HP:0003547)1.77494186
107Ankle contracture (HP:0006466)1.77101643
108Supernumerary ribs (HP:0005815)1.76493825
109Recurrent bronchitis (HP:0002837)1.76045598
110Birth length less than 3rd percentile (HP:0003561)1.75813730
111Agnosia (HP:0010524)1.75078030
112Multiple enchondromatosis (HP:0005701)1.74943984
113Biliary tract neoplasm (HP:0100574)1.74340218
114Broad phalanges of the hand (HP:0009768)1.74288521
115Agammaglobulinemia (HP:0004432)1.73885420
116Aplastic anemia (HP:0001915)1.73788577
117Facial hemangioma (HP:0000329)1.73353462
118Ectopic kidney (HP:0000086)1.73322220
119Abnormality of the diencephalon (HP:0010662)1.73310033
120Sacral dimple (HP:0000960)1.72754943
121Squamous cell carcinoma (HP:0002860)1.71769429
122Truncal obesity (HP:0001956)1.70966451
123Polygenic inheritance (HP:0010982)1.70809627
124Hypertensive crisis (HP:0100735)1.70753648
12511 pairs of ribs (HP:0000878)1.69951707
126Abnormality of the carotid arteries (HP:0005344)1.69788737
127Abnormality of oral frenula (HP:0000190)1.69115858
128Slender long bone (HP:0003100)1.69065877
129Macroorchidism (HP:0000053)1.68743447
130Abnormality of the thoracic spine (HP:0100711)1.67190285
131Bowel incontinence (HP:0002607)1.66883823
132Persistence of primary teeth (HP:0006335)1.66487204
133Short phalanx of the thumb (HP:0009660)1.65666058
134Myelodysplasia (HP:0002863)1.65572681
135Abnormality of the musculature of the pelvis (HP:0001469)1.65297388
136Abnormality of the hip-girdle musculature (HP:0001445)1.65297388
137Sparse lateral eyebrow (HP:0005338)1.65191855
138Acute lymphatic leukemia (HP:0006721)1.65186021
139Adenoma sebaceum (HP:0009720)1.65142256
140Angiofibromas (HP:0010615)1.65142256
141Spastic diplegia (HP:0001264)1.64657470
142Aplasia involving forearm bones (HP:0009822)1.64613229
143Absent forearm bone (HP:0003953)1.64613229
144Bladder diverticulum (HP:0000015)1.64496694
145Thoracic kyphosis (HP:0002942)1.64272718
146Spina bifida occulta (HP:0003298)1.63505711
147Fibrous tissue neoplasm (HP:0012316)1.63483715
148Syringomyelia (HP:0003396)1.63128750
149Spinal cord lesions (HP:0100561)1.63128750
150Sandal gap (HP:0001852)1.63008855
151Centrally nucleated skeletal muscle fibers (HP:0003687)1.62844596
152Neoplasm of the heart (HP:0100544)1.62730884
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.62710990
154Abnormal large intestine physiology (HP:0012700)1.62625239
155Delayed epiphyseal ossification (HP:0002663)1.62388332
156Self-mutilation (HP:0000742)1.61342606
157Ankyloglossia (HP:0010296)1.61010488
158Fatigue (HP:0012378)1.60821681
159Enlarged penis (HP:0000040)1.59909223
160Abnormality of cochlea (HP:0000375)1.59497001
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59496268
162Thin bony cortex (HP:0002753)1.59388706
163Fibroma (HP:0010614)1.59332333
164Low anterior hairline (HP:0000294)1.59090531
165Distal lower limb amyotrophy (HP:0008944)1.58922721
166Anal stenosis (HP:0002025)1.57843795
167Intestinal polyp (HP:0005266)1.57759319
168Abnormality of the metopic suture (HP:0005556)1.57682072
169Supernumerary bones of the axial skeleton (HP:0009144)1.56998200
170Abnormality of the humeroradial joint (HP:0100744)1.56567822
171Inflammation of the large intestine (HP:0002037)1.56025336
172Patellar dislocation (HP:0002999)1.55720055
173Metaphyseal cupping (HP:0003021)1.54818931
174Recurrent otitis media (HP:0000403)1.53941065
175Hypoplastic pelvis (HP:0008839)1.53543608
176Flat acetabular roof (HP:0003180)1.53112851
177Oligodactyly (HP:0012165)1.52661739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.16256424
2EEF2K3.86778725
3MAP3K103.63057152
4SMG13.45727537
5CDK123.23761389
6NEK23.05941312
7PKN22.95350077
8TRIB32.84239134
9PASK2.35287640
10FGFR42.34080951
11WEE12.30337882
12PRPF4B2.19543423
13MAP3K132.16153381
14BUB12.11820203
15SCYL21.94397341
16BRD41.90322607
17RPS6KB21.89918575
18NME21.79187326
19NEK11.77644067
20MAP3K141.71696031
21STK101.67141042
22PAK41.61851495
23MAP4K11.57090172
24CDK41.56584826
25* ATR1.50861254
26TSSK61.48489674
27TTK1.47678209
28CDK71.46823773
29TGFBR11.43297743
30TESK21.43228347
31CSNK1A1L1.41939407
32SRPK11.40651005
33RPS6KA41.37086191
34PTK61.35692717
35LRRK21.34366139
36ARAF1.33871078
37CSNK1G31.32879250
38DYRK31.32876855
39MKNK11.27354423
40MAP3K81.26126881
41ALK1.25446731
42ACVR1B1.25348077
43CHEK11.25226946
44CSNK1G11.23228630
45SIK21.22414786
46KSR21.21042017
47MTOR1.17973735
48PLK11.15996808
49AURKB1.14239743
50FLT31.13813392
51SIK31.13427881
52CDK61.13073879
53PDGFRA1.12636440
54IRAK31.12380048
55RIPK11.09777799
56ICK1.07623985
57TBK11.05135676
58TTN1.03872527
59FES0.97520807
60VRK20.97380450
61CDK20.92959050
62CHEK20.89931213
63TAOK20.84873294
64BRSK20.84549718
65SIK10.84355792
66MAP2K20.84062774
67PAK20.82204659
68TESK10.82127235
69RAF10.81810186
70MAP2K30.81481729
71MAP3K90.81461936
72* ATM0.81216137
73DYRK1B0.80712738
74EIF2AK10.79224533
75IKBKE0.78915863
76BRSK10.78666077
77ERN10.77321881
78FGFR10.74374869
79BTK0.74010169
80STK40.73933212
81CAMK1D0.73917402
82MKNK20.73607319
83GRK60.72539552
84PLK30.69131608
85CSK0.68599805
86DAPK10.66906441
87CDK10.66688112
88MAP3K110.66151614
89CSNK1G20.63645648
90LATS10.61489348
91CSF1R0.56659039
92STK30.56076032
93PIM10.55736304
94EPHA20.54854325
95NLK0.53969659
96TYRO30.53450408
97PRKDC0.52472071
98CAMK1G0.52033024
99KSR10.51715229
100LCK0.51337335
101PIM20.50902021
102MAPKAPK30.50610321
103BCKDK0.49865016
104JAK30.49860082
105CLK10.49632367
106AKT20.49631607
107TLK10.48648373
108FGFR30.46651537
109AURKA0.46409875
110ZAP700.46259525
111HIPK20.45594922
112MAPK100.45349435
113BRAF0.44930959
114TAOK10.44312732
115SYK0.43451479
116* MAPK110.42589797
117PDGFRB0.42188486
118BMX0.41240009
119* MAPK140.41235708
120PAK10.40818769
121PRKCI0.40424825
122CDK90.40152746
123ILK0.39947959
124ITK0.39271303
125MARK30.38234899
126HCK0.37751668
127UHMK10.36422252
128CSNK1E0.36362742
129AKT10.36333146
130CDK11A0.35887194
131RPS6KA10.34586302
132MATK0.34173033
133MAPK90.33848965
134CSNK2A20.33213488
135PLK40.33065542
136CSNK1D0.32564664
137GSK3B0.32537348
138CDK150.32073377
139KDR0.31732786
140ERBB20.31131675
141EPHA30.31026076

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.13680351
2Mismatch repair_Homo sapiens_hsa034303.29320599
3Spliceosome_Homo sapiens_hsa030403.23927577
4Cell cycle_Homo sapiens_hsa041102.67279055
5RNA transport_Homo sapiens_hsa030132.61932778
6Base excision repair_Homo sapiens_hsa034102.52657366
7mRNA surveillance pathway_Homo sapiens_hsa030152.19658986
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18544879
9One carbon pool by folate_Homo sapiens_hsa006702.09310765
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04318713
11Nucleotide excision repair_Homo sapiens_hsa034201.92910258
12Homologous recombination_Homo sapiens_hsa034401.88068249
13Chronic myeloid leukemia_Homo sapiens_hsa052201.55440087
14Fanconi anemia pathway_Homo sapiens_hsa034601.51204594
15Proteasome_Homo sapiens_hsa030501.49412450
16Notch signaling pathway_Homo sapiens_hsa043301.47703291
17Non-homologous end-joining_Homo sapiens_hsa034501.44822478
18Viral carcinogenesis_Homo sapiens_hsa052031.41942674
19RNA degradation_Homo sapiens_hsa030181.41908785
20p53 signaling pathway_Homo sapiens_hsa041151.40136908
21Antigen processing and presentation_Homo sapiens_hsa046121.38501900
22HTLV-I infection_Homo sapiens_hsa051661.38251994
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37263849
24MicroRNAs in cancer_Homo sapiens_hsa052061.36314863
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35712112
26Ribosome_Homo sapiens_hsa030101.32939303
27Colorectal cancer_Homo sapiens_hsa052101.32924063
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31968235
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29802974
30Other glycan degradation_Homo sapiens_hsa005111.26743140
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26499025
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25559810
33Small cell lung cancer_Homo sapiens_hsa052221.23814720
34Lysine degradation_Homo sapiens_hsa003101.18782099
35Oocyte meiosis_Homo sapiens_hsa041141.18311686
36Primary immunodeficiency_Homo sapiens_hsa053401.16768824
37Herpes simplex infection_Homo sapiens_hsa051681.15620451
38Epstein-Barr virus infection_Homo sapiens_hsa051691.13667549
39Basal cell carcinoma_Homo sapiens_hsa052171.13247556
40mTOR signaling pathway_Homo sapiens_hsa041501.12676979
41Systemic lupus erythematosus_Homo sapiens_hsa053221.07471590
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07360466
43Non-small cell lung cancer_Homo sapiens_hsa052231.05334689
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.02971069
45Thyroid cancer_Homo sapiens_hsa052161.02970710
46B cell receptor signaling pathway_Homo sapiens_hsa046621.02200767
47* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00345197
48Fructose and mannose metabolism_Homo sapiens_hsa000510.98394906
49Pyrimidine metabolism_Homo sapiens_hsa002400.96460648
50Acute myeloid leukemia_Homo sapiens_hsa052210.96194188
51Hippo signaling pathway_Homo sapiens_hsa043900.94529618
52Bladder cancer_Homo sapiens_hsa052190.93376079
53Endometrial cancer_Homo sapiens_hsa052130.92994193
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91313954
55Adherens junction_Homo sapiens_hsa045200.90388584
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.87419891
57Proteoglycans in cancer_Homo sapiens_hsa052050.86976858
58Hepatitis B_Homo sapiens_hsa051610.86633998
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86459185
60Pancreatic cancer_Homo sapiens_hsa052120.86105290
61Carbon metabolism_Homo sapiens_hsa012000.85648942
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85565613
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.85270890
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84301621
65Viral myocarditis_Homo sapiens_hsa054160.83521658
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81370553
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81037444
68Prion diseases_Homo sapiens_hsa050200.80555535
69Basal transcription factors_Homo sapiens_hsa030220.78795512
70T cell receptor signaling pathway_Homo sapiens_hsa046600.78088701
71Hedgehog signaling pathway_Homo sapiens_hsa043400.77436311
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74349559
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73757729
74Alcoholism_Homo sapiens_hsa050340.72829988
75Hepatitis C_Homo sapiens_hsa051600.71857080
76Apoptosis_Homo sapiens_hsa042100.71835427
77Selenocompound metabolism_Homo sapiens_hsa004500.70591000
78Pathways in cancer_Homo sapiens_hsa052000.69786045
79Shigellosis_Homo sapiens_hsa051310.68828796
80Glioma_Homo sapiens_hsa052140.68810117
81RNA polymerase_Homo sapiens_hsa030200.66795089
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66210576
83Wnt signaling pathway_Homo sapiens_hsa043100.65722310
84TNF signaling pathway_Homo sapiens_hsa046680.65319671
85N-Glycan biosynthesis_Homo sapiens_hsa005100.64202558
86Measles_Homo sapiens_hsa051620.63317581
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.63069828
88Allograft rejection_Homo sapiens_hsa053300.63048498
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63020142
90VEGF signaling pathway_Homo sapiens_hsa043700.62907643
91Graft-versus-host disease_Homo sapiens_hsa053320.61096912
92HIF-1 signaling pathway_Homo sapiens_hsa040660.60714776
93TGF-beta signaling pathway_Homo sapiens_hsa043500.58999739
94Sulfur relay system_Homo sapiens_hsa041220.58692224
95Prostate cancer_Homo sapiens_hsa052150.58435854
96Legionellosis_Homo sapiens_hsa051340.57923928
97Autoimmune thyroid disease_Homo sapiens_hsa053200.57731116
98Focal adhesion_Homo sapiens_hsa045100.57088787
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.56893410
100Salmonella infection_Homo sapiens_hsa051320.54221421
101Biosynthesis of amino acids_Homo sapiens_hsa012300.52956826
102Estrogen signaling pathway_Homo sapiens_hsa049150.51191038
103Toxoplasmosis_Homo sapiens_hsa051450.51173833
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50853949
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50328693
106FoxO signaling pathway_Homo sapiens_hsa040680.50311231
107Influenza A_Homo sapiens_hsa051640.49039351
108Choline metabolism in cancer_Homo sapiens_hsa052310.48754561
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.48223183
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.47651004
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47622988
112Platelet activation_Homo sapiens_hsa046110.45120404
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45048495
114Renal cell carcinoma_Homo sapiens_hsa052110.45026987
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44626026
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44557747
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44508199
118Osteoclast differentiation_Homo sapiens_hsa043800.43071745
119Insulin signaling pathway_Homo sapiens_hsa049100.41596089
120Purine metabolism_Homo sapiens_hsa002300.41361087
121AMPK signaling pathway_Homo sapiens_hsa041520.41188291
122Pentose phosphate pathway_Homo sapiens_hsa000300.40378829
123Prolactin signaling pathway_Homo sapiens_hsa049170.39575089
124Insulin resistance_Homo sapiens_hsa049310.38405748
125Leishmaniasis_Homo sapiens_hsa051400.36858112

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