EXD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)5.20459432
2daunorubicin metabolic process (GO:0044597)5.20459432
3polyketide metabolic process (GO:0030638)5.20459432
4behavioral response to nicotine (GO:0035095)5.15787675
5fucose catabolic process (GO:0019317)4.62183605
6L-fucose metabolic process (GO:0042354)4.62183605
7L-fucose catabolic process (GO:0042355)4.62183605
8protein polyglutamylation (GO:0018095)4.28014052
9superoxide anion generation (GO:0042554)4.22458339
10response to pheromone (GO:0019236)4.14788942
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.07418825
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.92277253
13axoneme assembly (GO:0035082)3.86774839
14axonemal dynein complex assembly (GO:0070286)3.72272376
15platelet dense granule organization (GO:0060155)3.72082059
16detection of light stimulus involved in sensory perception (GO:0050962)3.69813858
17detection of light stimulus involved in visual perception (GO:0050908)3.69813858
18cellular ketone body metabolic process (GO:0046950)3.59406381
19kynurenine metabolic process (GO:0070189)3.58155656
20microtubule depolymerization (GO:0007019)3.55960588
21regulation of timing of cell differentiation (GO:0048505)3.55379602
22centriole assembly (GO:0098534)3.55212985
23DNA methylation involved in gamete generation (GO:0043046)3.54636961
24DNA deamination (GO:0045006)3.54409469
25indole-containing compound catabolic process (GO:0042436)3.54152730
26indolalkylamine catabolic process (GO:0046218)3.54152730
27tryptophan catabolic process (GO:0006569)3.54152730
28piRNA metabolic process (GO:0034587)3.53793721
29cilium or flagellum-dependent cell motility (GO:0001539)3.45380001
30regulation of glucokinase activity (GO:0033131)3.33571982
31regulation of hexokinase activity (GO:1903299)3.33571982
32indolalkylamine metabolic process (GO:0006586)3.27384202
33protein K6-linked ubiquitination (GO:0085020)3.24168445
34ketone body metabolic process (GO:1902224)3.19702550
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17986539
36regulation of telomere maintenance (GO:0032204)3.16951348
37cilium morphogenesis (GO:0060271)3.14977107
38keratinocyte development (GO:0003334)3.14910115
39mannosylation (GO:0097502)3.13850378
40retinal cone cell development (GO:0046549)3.13044905
41regulation of development, heterochronic (GO:0040034)3.12871013
42water-soluble vitamin biosynthetic process (GO:0042364)3.12150874
43synapsis (GO:0007129)3.12086647
44auditory receptor cell stereocilium organization (GO:0060088)3.11627679
45rRNA methylation (GO:0031167)3.07374505
46motile cilium assembly (GO:0044458)3.06131575
47proline transport (GO:0015824)3.05001899
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.04841641
49NADH dehydrogenase complex assembly (GO:0010257)3.04841641
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04841641
51mesenchymal cell differentiation involved in kidney development (GO:0072161)3.04463585
52mesenchymal cell differentiation involved in renal system development (GO:2001012)3.04463585
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.03834835
54female gonad development (GO:0008585)3.02740766
55cilium movement (GO:0003341)3.01195349
56aminoglycoside antibiotic metabolic process (GO:0030647)2.99571046
57glycerophospholipid catabolic process (GO:0046475)2.99447954
58cellular response to ATP (GO:0071318)2.98840250
59photoreceptor cell maintenance (GO:0045494)2.98246356
60protein localization to cilium (GO:0061512)2.98069239
61tryptophan metabolic process (GO:0006568)2.97793421
62kinetochore assembly (GO:0051382)2.97246117
63rRNA catabolic process (GO:0016075)2.95917077
64DNA integration (GO:0015074)2.94396970
65regulation of meiosis I (GO:0060631)2.93852326
66limb bud formation (GO:0060174)2.93755870
67nonmotile primary cilium assembly (GO:0035058)2.92956992
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92188347
69L-methionine salvage (GO:0071267)2.91887370
70L-methionine biosynthetic process (GO:0071265)2.91887370
71amino acid salvage (GO:0043102)2.91887370
72centriole replication (GO:0007099)2.91068157
73rRNA modification (GO:0000154)2.90425819
74negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89330425
75epithelial cilium movement (GO:0003351)2.87846579
76preassembly of GPI anchor in ER membrane (GO:0016254)2.87727572
77gamma-aminobutyric acid transport (GO:0015812)2.87249928
78regulation of action potential (GO:0098900)2.86483592
79neuronal action potential (GO:0019228)2.85529632
80alanine transport (GO:0032328)2.85519212
81synaptic transmission, cholinergic (GO:0007271)2.85404599
82pyrimidine nucleobase catabolic process (GO:0006208)2.83763444
83multicellular organism reproduction (GO:0032504)2.83701337
84inner ear receptor stereocilium organization (GO:0060122)2.81820307
85GPI anchor biosynthetic process (GO:0006506)2.81605683
86startle response (GO:0001964)2.81203404
87reflex (GO:0060004)2.80555463
88behavioral response to ethanol (GO:0048149)2.79722014
89adaptation of signaling pathway (GO:0023058)2.78877701
90negative regulation of execution phase of apoptosis (GO:1900118)2.78867646
91protein complex biogenesis (GO:0070271)2.78130702
92DNA ligation (GO:0006266)2.75371656
93indole-containing compound metabolic process (GO:0042430)2.75236232
94omega-hydroxylase P450 pathway (GO:0097267)2.72329495
95primary amino compound metabolic process (GO:1901160)2.69568459
96amine catabolic process (GO:0009310)2.68987732
97cellular biogenic amine catabolic process (GO:0042402)2.68987732
98regulation of cilium movement (GO:0003352)2.67751220
99GPI anchor metabolic process (GO:0006505)2.67402450
100photoreceptor cell development (GO:0042461)2.67384092
101phosphatidylinositol acyl-chain remodeling (GO:0036149)2.66308333
102respiratory chain complex IV assembly (GO:0008535)2.66251140
103mesonephros development (GO:0001823)2.65022939
104replication fork processing (GO:0031297)2.64998046
105RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64919838
106interferon-gamma production (GO:0032609)2.64712118
107fucosylation (GO:0036065)2.62350269
108recombinational repair (GO:0000725)2.62033687
109nucleobase catabolic process (GO:0046113)2.61676975
110cell proliferation in forebrain (GO:0021846)2.61365451
111termination of RNA polymerase I transcription (GO:0006363)2.61344002
112cilium organization (GO:0044782)2.60490970
113transcription elongation from RNA polymerase I promoter (GO:0006362)2.60388551
114transmission of nerve impulse (GO:0019226)2.60372616
115negative regulation of keratinocyte proliferation (GO:0010839)2.60292489
116tRNA methylation (GO:0030488)2.60233791
117negative regulation of reactive oxygen species metabolic process (GO:2000378)2.59850151
118sulfate transport (GO:0008272)2.59824514
119regulation of activation of Janus kinase activity (GO:0010533)2.59441163
120maturation of 5.8S rRNA (GO:0000460)2.59297364
121otic vesicle formation (GO:0030916)2.59277301
122replicative senescence (GO:0090399)2.59048268
123regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58982855
124negative regulation of telomere maintenance (GO:0032205)2.58956343
125rhodopsin mediated signaling pathway (GO:0016056)2.57526445
126double-strand break repair via homologous recombination (GO:0000724)2.57496020
127anterograde synaptic vesicle transport (GO:0048490)2.57422293
128S-adenosylmethionine metabolic process (GO:0046500)2.56929362
129intraciliary transport (GO:0042073)2.54641709
130cerebral cortex radially oriented cell migration (GO:0021799)2.53573763
131mitochondrial respiratory chain complex assembly (GO:0033108)2.53415244
132regulation of telomere maintenance via telomerase (GO:0032210)2.53079855
133positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.52317974
134positive regulation of fatty acid transport (GO:2000193)2.51768544
135polyol transport (GO:0015791)2.50851606
136resolution of meiotic recombination intermediates (GO:0000712)2.50497802
137neural tube formation (GO:0001841)2.49955265
138G-protein coupled receptor internalization (GO:0002031)2.49682512
139androgen biosynthetic process (GO:0006702)2.49294147
140adenosine metabolic process (GO:0046085)2.49171780
141transcription from RNA polymerase I promoter (GO:0006360)2.48238848
142negative regulation of myoblast differentiation (GO:0045662)2.47009492
143DNA synthesis involved in DNA repair (GO:0000731)2.46253854
144proteasome assembly (GO:0043248)2.45516423
145response to folic acid (GO:0051593)2.44083674
146DNA damage response, detection of DNA damage (GO:0042769)2.43757801
147nucleotide transmembrane transport (GO:1901679)2.43461946
148regulation of non-canonical Wnt signaling pathway (GO:2000050)2.43120474
149transcription elongation from RNA polymerase III promoter (GO:0006385)2.42693871
150termination of RNA polymerase III transcription (GO:0006386)2.42693871
151positive regulation of interleukin-1 beta secretion (GO:0050718)2.42328217
152kinetochore organization (GO:0051383)2.41199183
153ventricular system development (GO:0021591)2.40471448
154positive regulation of DNA-dependent DNA replication (GO:2000105)2.40307892
155negative regulation of homotypic cell-cell adhesion (GO:0034111)2.37950400
156oligosaccharide catabolic process (GO:0009313)2.37848517
157regulation of double-strand break repair via homologous recombination (GO:0010569)2.37437662
158cell differentiation involved in metanephros development (GO:0072202)2.37188213
159lymphoid progenitor cell differentiation (GO:0002320)2.37161302
160reciprocal DNA recombination (GO:0035825)2.36629021
161reciprocal meiotic recombination (GO:0007131)2.36629021
162response to X-ray (GO:0010165)2.35088833
163sphingoid metabolic process (GO:0046519)2.32803703
164dendritic cell chemotaxis (GO:0002407)2.32740674
165developmental pigmentation (GO:0048066)2.32279672
166amino sugar catabolic process (GO:0046348)2.32085491
167epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.31624688
168negative regulation of systemic arterial blood pressure (GO:0003085)2.31024668
169cilium assembly (GO:0042384)2.29750184
170kidney morphogenesis (GO:0060993)2.28611243
171cellular response to gamma radiation (GO:0071480)2.28314126
172natural killer cell activation involved in immune response (GO:0002323)2.27049462
173regulation of interleukin-8 secretion (GO:2000482)2.26550438
174negative regulation of mast cell activation (GO:0033004)2.25928967
175male meiosis I (GO:0007141)2.25637506
176ceramide catabolic process (GO:0046514)2.25421278
177male meiosis (GO:0007140)2.25259384
178positive regulation of defense response to virus by host (GO:0002230)2.24155232
179histone H2B ubiquitination (GO:0033523)2.23185745
180sympathetic nervous system development (GO:0048485)2.22409734
181RNA methylation (GO:0001510)2.22072972
182presynaptic membrane assembly (GO:0097105)2.22060331
183DNA double-strand break processing (GO:0000729)2.21951894
184microtubule polymerization or depolymerization (GO:0031109)2.21879771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.25903902
2PCGF2_27294783_Chip-Seq_ESCs_Mouse3.23309666
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.16442742
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.15587424
5GBX2_23144817_ChIP-Seq_PC3_Human2.97666870
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87751847
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72042318
8PCGF2_27294783_Chip-Seq_NPCs_Mouse2.63354349
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.60042321
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58606946
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.53232708
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.48825734
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.44622860
14IGF1R_20145208_ChIP-Seq_DFB_Human2.35678013
15EZH2_22144423_ChIP-Seq_EOC_Human2.33322518
16VDR_22108803_ChIP-Seq_LS180_Human2.20923449
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20252005
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.13543879
19RNF2_27304074_Chip-Seq_NSC_Mouse2.11769048
20EZH2_27294783_Chip-Seq_NPCs_Mouse2.01602817
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.98408733
22IRF1_19129219_ChIP-ChIP_H3396_Human1.96120481
23EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.93129373
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.92451920
25* STAT3_18555785_Chip-Seq_ESCs_Mouse1.91333114
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91080324
27* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.89720400
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88501179
29EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.86872474
30* NMYC_18555785_Chip-Seq_ESCs_Mouse1.86208743
31* E2F1_18555785_Chip-Seq_ESCs_Mouse1.86054256
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.84126718
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.82804687
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80122877
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80122877
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80122877
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79309680
38P53_22387025_ChIP-Seq_ESCs_Mouse1.76909865
39* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.76612970
40* P300_18555785_Chip-Seq_ESCs_Mouse1.74076844
41* OCT4_18555785_Chip-Seq_ESCs_Mouse1.73786211
42* ZFX_18555785_Chip-Seq_ESCs_Mouse1.70819369
43TP53_22573176_ChIP-Seq_HFKS_Human1.70607247
44CMYC_18555785_Chip-Seq_ESCs_Mouse1.69539424
45* KLF4_18555785_Chip-Seq_ESCs_Mouse1.67252843
46SOX2_18555785_Chip-Seq_ESCs_Mouse1.66625418
47CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64933294
48* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.64012146
49* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.59991146
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59974141
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58374523
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.58146026
53CBP_20019798_ChIP-Seq_JUKART_Human1.58094666
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58094666
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.56553405
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.55702997
57PU1_27457419_Chip-Seq_LIVER_Mouse1.53392472
58MYC_18940864_ChIP-ChIP_HL60_Human1.51254564
59* CTCF_18555785_Chip-Seq_ESCs_Mouse1.50735293
60TAF15_26573619_Chip-Seq_HEK293_Human1.49604558
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.47542507
62FUS_26573619_Chip-Seq_HEK293_Human1.47046823
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.46851594
64BCAT_22108803_ChIP-Seq_LS180_Human1.45291101
65TCF4_23295773_ChIP-Seq_U87_Human1.44345327
66AR_25329375_ChIP-Seq_VCAP_Human1.44183355
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.41278962
68NANOG_19829295_ChIP-Seq_ESCs_Human1.41195457
69SOX2_19829295_ChIP-Seq_ESCs_Human1.41195457
70REST_21632747_ChIP-Seq_MESCs_Mouse1.40498673
71P300_19829295_ChIP-Seq_ESCs_Human1.40307260
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.40293618
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.39212207
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36957565
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36259815
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35405380
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.35156173
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34960434
79HOXB7_26014856_ChIP-Seq_BT474_Human1.34955800
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32377702
81TCF4_22108803_ChIP-Seq_LS180_Human1.31971368
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31804425
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31002840
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30840591
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30840591
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30504099
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29383376
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28842685
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.28695975
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.26738205
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26738205
92* NCOR_22424771_ChIP-Seq_293T_Human1.25448967
93* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24764293
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.24183498
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23077291
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22778746
97ER_23166858_ChIP-Seq_MCF-7_Human1.22530290
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21530441
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20825216
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.20141782
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18961631
102EWS_26573619_Chip-Seq_HEK293_Human1.18347951
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18325935
104AR_20517297_ChIP-Seq_VCAP_Human1.17941885
105AR_21572438_ChIP-Seq_LNCaP_Human1.17894612
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.17166242
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15520433
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14724300
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12405441
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11700062
111* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11215212
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09427528
113ELK1_19687146_ChIP-ChIP_HELA_Human1.09159370
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08837543
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.08018157
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07808633
117ERA_21632823_ChIP-Seq_H3396_Human1.06824139
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06334102
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05717327
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.04680085
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04598132
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04497355
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03987236
124MYC_19829295_ChIP-Seq_ESCs_Human1.03900680
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03035396
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00306074
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.99517497
128VDR_23849224_ChIP-Seq_CD4+_Human0.99288953
129RUNX2_22187159_ChIP-Seq_PCA_Human0.98849399
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98651481
131SMAD4_21799915_ChIP-Seq_A2780_Human0.98605146
132ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98531493
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96097498
134TAF2_19829295_ChIP-Seq_ESCs_Human0.96071135
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95296969
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94904308
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94355070
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.94315488
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94100309
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93975029
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93191272
142CDX2_22108803_ChIP-Seq_LS180_Human0.93160958
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.93094925
144STAT3_23295773_ChIP-Seq_U87_Human0.92861119
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92648796
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91818995
147SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91311576
148RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91175720
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89283316
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.88967250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.80333449
2MP0003136_yellow_coat_color4.21489806
3MP0000566_synostosis3.88879969
4MP0001188_hyperpigmentation3.40764143
5MP0002277_abnormal_respiratory_mucosa3.01000913
6MP0002102_abnormal_ear_morphology2.92978036
7MP0004381_abnormal_hair_follicle2.92464817
8MP0003195_calcinosis2.65075823
9MP0002132_abnormal_respiratory_system2.49648237
10MP0003646_muscle_fatigue2.43891261
11MP0001968_abnormal_touch/_nociception2.36918600
12MP0006072_abnormal_retinal_apoptosis2.30070202
13MP0008058_abnormal_DNA_repair2.22707545
14MP0005409_darkened_coat_color2.09921474
15MP0008875_abnormal_xenobiotic_pharmacok2.09331547
16MP0008872_abnormal_physiological_respon2.08746108
17MP0005171_absent_coat_pigmentation2.08208864
18MP0000569_abnormal_digit_pigmentation2.05701157
19MP0002837_dystrophic_cardiac_calcinosis2.03822057
20MP0001986_abnormal_taste_sensitivity2.01553861
21MP0004043_abnormal_pH_regulation2.01031916
22MP0004147_increased_porphyrin_level2.00219473
23MP0003941_abnormal_skin_development1.94764178
24MP0008057_abnormal_DNA_replication1.89785655
25MP0009745_abnormal_behavioral_response1.85853069
26MP0002736_abnormal_nociception_after1.85818649
27MP0003011_delayed_dark_adaptation1.81967467
28MP0009046_muscle_twitch1.81246435
29MP0002653_abnormal_ependyma_morphology1.78842504
30MP0005075_abnormal_melanosome_morpholog1.76392032
31MP0002272_abnormal_nervous_system1.75680881
32MP0000015_abnormal_ear_pigmentation1.74642969
33MP0003938_abnormal_ear_development1.73320774
34MP0003880_abnormal_central_pattern1.73009722
35MP0000383_abnormal_hair_follicle1.67587739
36MP0003718_maternal_effect1.64260131
37MP0001501_abnormal_sleep_pattern1.64226141
38MP0005084_abnormal_gallbladder_morpholo1.60864852
39MP0000372_irregular_coat_pigmentation1.59648777
40MP0005499_abnormal_olfactory_system1.58378726
41MP0005394_taste/olfaction_phenotype1.58378726
42MP0008789_abnormal_olfactory_epithelium1.57632435
43MP0005646_abnormal_pituitary_gland1.56182983
44MP0004885_abnormal_endolymph1.55565767
45MP0005645_abnormal_hypothalamus_physiol1.53818358
46MP0000427_abnormal_hair_cycle1.49386951
47MP0000026_abnormal_inner_ear1.49368618
48MP0002735_abnormal_chemical_nociception1.49218961
49MP0005379_endocrine/exocrine_gland_phen1.48884730
50MP0004742_abnormal_vestibular_system1.48763341
51MP0005451_abnormal_body_composition1.47771050
52MP0003787_abnormal_imprinting1.46382133
53MP0008260_abnormal_autophagy1.45357713
54MP0005257_abnormal_intraocular_pressure1.43984068
55MP0004145_abnormal_muscle_electrophysio1.43154175
56MP0000049_abnormal_middle_ear1.42889119
57MP0002163_abnormal_gland_morphology1.41467349
58MP0002249_abnormal_larynx_morphology1.40753684
59MP0002733_abnormal_thermal_nociception1.40488946
60MP0008877_abnormal_DNA_methylation1.38068555
61MP0002638_abnormal_pupillary_reflex1.36234094
62MP0003786_premature_aging1.34795645
63MP0000613_abnormal_salivary_gland1.30767797
64MP0005410_abnormal_fertilization1.30167339
65MP0002876_abnormal_thyroid_physiology1.29927067
66MP0002064_seizures1.28827307
67MP0002938_white_spotting1.26114542
68MP0008995_early_reproductive_senescence1.25474475
69MP0002009_preneoplasia1.24522221
70MP0009697_abnormal_copulation1.24342880
71MP0002572_abnormal_emotion/affect_behav1.23721829
72MP0002928_abnormal_bile_duct1.23222793
73MP0002098_abnormal_vibrissa_morphology1.22700540
74MP0001970_abnormal_pain_threshold1.22063846
75MP0001486_abnormal_startle_reflex1.20380465
76MP0003111_abnormal_nucleus_morphology1.19686251
77MP0010094_abnormal_chromosome_stability1.18511990
78MP0003937_abnormal_limbs/digits/tail_de1.17223152
79MP0000762_abnormal_tongue_morphology1.17191279
80MP0002210_abnormal_sex_determination1.16639134
81MP0003724_increased_susceptibility_to1.16635095
82MP0005195_abnormal_posterior_eye1.16360918
83MP0001346_abnormal_lacrimal_gland1.15867520
84MP0003878_abnormal_ear_physiology1.15013615
85MP0005377_hearing/vestibular/ear_phenot1.15013615
86MP0005174_abnormal_tail_pigmentation1.14292365
87MP0001984_abnormal_olfaction1.12010176
88MP0006276_abnormal_autonomic_nervous1.11470498
89MP0005248_abnormal_Harderian_gland1.09884779
90MP0002067_abnormal_sensory_capabilities1.09267097
91MP0002234_abnormal_pharynx_morphology1.08876679
92MP0008775_abnormal_heart_ventricle1.08837373
93MP0002557_abnormal_social/conspecific_i1.08169897
94MP0000678_abnormal_parathyroid_gland1.07208369
95MP0001502_abnormal_circadian_rhythm1.07071209
96MP0002734_abnormal_mechanical_nocicepti1.04654904
97MP0002233_abnormal_nose_morphology1.03691575
98MP0009379_abnormal_foot_pigmentation1.03081104
99MP0001963_abnormal_hearing_physiology1.03032683
100MP0001324_abnormal_eye_pigmentation1.02937924
101MP0002254_reproductive_system_inflammat1.02747439
102MP0005167_abnormal_blood-brain_barrier1.02532669
103MP0005386_behavior/neurological_phenoty1.02183231
104MP0004924_abnormal_behavior1.02183231
105MP0003252_abnormal_bile_duct1.01467429
106MP0002095_abnormal_skin_pigmentation1.00884100
107MP0009250_abnormal_appendicular_skeleto1.00053880
108MP0001119_abnormal_female_reproductive0.99148266
109MP0005085_abnormal_gallbladder_physiolo0.99024045
110MP0002063_abnormal_learning/memory/cond0.98414366
111MP0003635_abnormal_synaptic_transmissio0.98095375
112MP0003122_maternal_imprinting0.95486240
113MP0001919_abnormal_reproductive_system0.94850357
114MP0001529_abnormal_vocalization0.94780409
115MP0003698_abnormal_male_reproductive0.94236653
116MP0003890_abnormal_embryonic-extraembry0.94011402
117MP0005389_reproductive_system_phenotype0.93222299
118MP0005332_abnormal_amino_acid0.93013799
119MP0004215_abnormal_myocardial_fiber0.92962909
120MP0001929_abnormal_gametogenesis0.92492168
121MP0001905_abnormal_dopamine_level0.92379515
122MP0002148_abnormal_hypersensitivity_rea0.91012489
123MP0002184_abnormal_innervation0.90603815
124MP0002160_abnormal_reproductive_system0.90550276
125MP0003315_abnormal_perineum_morphology0.89406655
126MP0000631_abnormal_neuroendocrine_gland0.88774107
127MP0002229_neurodegeneration0.87131398
128MP0004782_abnormal_surfactant_physiolog0.86837260
129MP0005423_abnormal_somatic_nervous0.86500761
130MP0000647_abnormal_sebaceous_gland0.86336088
131MP0003121_genomic_imprinting0.85820833
132MP0000230_abnormal_systemic_arterial0.85691678
133MP0003283_abnormal_digestive_organ0.85648709
134MP0001186_pigmentation_phenotype0.85648276
135MP0002177_abnormal_outer_ear0.85218631
136MP0001286_abnormal_eye_development0.85153389
137MP0004142_abnormal_muscle_tone0.85102807
138MP0003137_abnormal_impulse_conducting0.84061328
139MP0001764_abnormal_homeostasis0.83811111
140MP0004133_heterotaxia0.83676446
141MP0002751_abnormal_autonomic_nervous0.82430168
142MP0003755_abnormal_palate_morphology0.81435563
143MP0000490_abnormal_crypts_of0.80619738
144MP0000653_abnormal_sex_gland0.80389212
145MP0010386_abnormal_urinary_bladder0.79877167
146MP0001145_abnormal_male_reproductive0.78288128
147MP0005253_abnormal_eye_physiology0.78238206
148MP0001485_abnormal_pinna_reflex0.77379207
149MP0002752_abnormal_somatic_nervous0.74389156
150MP0005670_abnormal_white_adipose0.74228458
151MP0000681_abnormal_thyroid_gland0.73758213
152MP0005647_abnormal_sex_gland0.73137391
153MP0005551_abnormal_eye_electrophysiolog0.71332148
154MP0002138_abnormal_hepatobiliary_system0.70138570

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.57370665
2Chromsome breakage (HP:0040012)4.89898557
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.40300304
4Type II lissencephaly (HP:0007260)3.82310336
5Congenital stationary night blindness (HP:0007642)3.80675236
6Abnormal ciliary motility (HP:0012262)3.74711129
7Absent/shortened dynein arms (HP:0200106)3.74577373
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.74577373
9Abnormality of the renal cortex (HP:0011035)3.67775422
10Abnormal respiratory motile cilium physiology (HP:0012261)3.45418120
11Abnormal drinking behavior (HP:0030082)3.42374126
12Polydipsia (HP:0001959)3.42374126
13Duplicated collecting system (HP:0000081)3.36121588
14Abnormality of the renal medulla (HP:0100957)3.23840886
15Abnormality of the renal collecting system (HP:0004742)3.23793618
16Abnormal respiratory epithelium morphology (HP:0012253)3.20315636
17Abnormal respiratory motile cilium morphology (HP:0005938)3.20315636
18Abolished electroretinogram (ERG) (HP:0000550)3.04339158
19Septo-optic dysplasia (HP:0100842)2.96960273
20Abnormality of alanine metabolism (HP:0010916)2.95240097
21Hyperalaninemia (HP:0003348)2.95240097
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.95240097
23Cystic liver disease (HP:0006706)2.93556006
24Cerebellar dysplasia (HP:0007033)2.85832618
25Pendular nystagmus (HP:0012043)2.82552513
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.81379382
27Attenuation of retinal blood vessels (HP:0007843)2.80092119
28Inability to walk (HP:0002540)2.78824847
29Meckel diverticulum (HP:0002245)2.78168528
30Abnormality of the preputium (HP:0100587)2.75323133
31Hyperventilation (HP:0002883)2.75031180
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.74193349
33Hypoplasia of the fovea (HP:0007750)2.74193349
34Polyuria (HP:0000103)2.71927695
35Progressive inability to walk (HP:0002505)2.71088492
36Duplication of thumb phalanx (HP:0009942)2.69270008
37Abnormality of the ileum (HP:0001549)2.60623996
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.54853263
39Tubular atrophy (HP:0000092)2.53658693
40True hermaphroditism (HP:0010459)2.53309323
41Sclerocornea (HP:0000647)2.51508770
42Clubbing of toes (HP:0100760)2.50863657
43Abnormality of secondary sexual hair (HP:0009888)2.48436370
44Abnormality of the axillary hair (HP:0100134)2.48436370
45Upper limb muscle weakness (HP:0003484)2.48376427
46Abnormal rod and cone electroretinograms (HP:0008323)2.47131392
47Prostate neoplasm (HP:0100787)2.42779768
48Pancreatic fibrosis (HP:0100732)2.42656167
49Pancreatic cysts (HP:0001737)2.41629251
50Lissencephaly (HP:0001339)2.38978741
51Parakeratosis (HP:0001036)2.38116803
52Stomach cancer (HP:0012126)2.37349681
53Asplenia (HP:0001746)2.37121570
54Gait imbalance (HP:0002141)2.35946238
55Nephroblastoma (Wilms tumor) (HP:0002667)2.35344585
56Nasolacrimal duct obstruction (HP:0000579)2.32589606
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.30970843
58Reduced antithrombin III activity (HP:0001976)2.30064398
59Congenital primary aphakia (HP:0007707)2.29091500
60Decreased circulating renin level (HP:0003351)2.27169880
61Supernumerary spleens (HP:0009799)2.25253134
62Renal cortical cysts (HP:0000803)2.24921933
63Abnormality of chromosome stability (HP:0003220)2.24303212
64Osteomalacia (HP:0002749)2.24234303
65Ectopic kidney (HP:0000086)2.23273897
66Anomalous pulmonary venous return (HP:0010772)2.22503720
67Embryonal renal neoplasm (HP:0011794)2.19640656
68Optic nerve hypoplasia (HP:0000609)2.19171189
69Increased corneal curvature (HP:0100692)2.18655640
70Keratoconus (HP:0000563)2.18655640
71Aplasia cutis congenita (HP:0001057)2.17592087
72Nephrogenic diabetes insipidus (HP:0009806)2.16448459
73Male pseudohermaphroditism (HP:0000037)2.15856509
74Abnormal urine output (HP:0012590)2.15685226
75Methylmalonic acidemia (HP:0002912)2.15239990
76Adrenal hypoplasia (HP:0000835)2.12204651
77Congenital, generalized hypertrichosis (HP:0004540)2.11585683
78Clumsiness (HP:0002312)2.11134941
793-Methylglutaconic aciduria (HP:0003535)2.11051884
80Congenital sensorineural hearing impairment (HP:0008527)2.10859664
81Patchy hypopigmentation of hair (HP:0011365)2.10823172
82White forelock (HP:0002211)2.10784726
83Hypomagnesemia (HP:0002917)2.09547151
84Abnormality of incisor morphology (HP:0011063)2.09142082
85Type I transferrin isoform profile (HP:0003642)2.08301073
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07911215
87Tubulointerstitial nephritis (HP:0001970)2.07089661
88Microvesicular hepatic steatosis (HP:0001414)2.06558593
89Abnormality of the pons (HP:0007361)2.06216972
90Pachygyria (HP:0001302)2.05628906
91Absent septum pellucidum (HP:0001331)2.04964209
92Preaxial hand polydactyly (HP:0001177)2.03470983
93Cheilitis (HP:0100825)2.02625063
94Abnormality of the septum pellucidum (HP:0007375)2.02253204
95Conical tooth (HP:0000698)2.01860555
96Abnormality of the fovea (HP:0000493)2.01164850
97Large for gestational age (HP:0001520)2.00101859
98Partial duplication of thumb phalanx (HP:0009944)1.99919994
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99267509
100Triphalangeal thumb (HP:0001199)1.98652539
101Broad-based gait (HP:0002136)1.98133027
102Furrowed tongue (HP:0000221)1.97461393
103Abnormality of the lacrimal duct (HP:0011481)1.96921293
104Median cleft lip (HP:0000161)1.96674868
105Rhinitis (HP:0012384)1.96350746
106Medial flaring of the eyebrow (HP:0010747)1.95990251
107Decreased central vision (HP:0007663)1.94673027
108Hyperglycinuria (HP:0003108)1.94453176
109Retinal dysplasia (HP:0007973)1.94351612
110Severe muscular hypotonia (HP:0006829)1.93900372
111Hypoplasia of the pons (HP:0012110)1.92498403
112Hepatic necrosis (HP:0002605)1.92299172
113Abnormality of the pulmonary veins (HP:0011718)1.91722678
114Molar tooth sign on MRI (HP:0002419)1.88123528
115Abnormality of midbrain morphology (HP:0002418)1.88123528
116Hemiparesis (HP:0001269)1.88072406
117Increased CSF lactate (HP:0002490)1.87840157
118Protruding tongue (HP:0010808)1.86886167
119Methylmalonic aciduria (HP:0012120)1.86535333
120Optic neuritis (HP:0100653)1.86017356
121Retrobulbar optic neuritis (HP:0100654)1.86017356
122Duodenal stenosis (HP:0100867)1.85588410
123Small intestinal stenosis (HP:0012848)1.85588410
124Fair hair (HP:0002286)1.85206215
125Febrile seizures (HP:0002373)1.85003980
126Congenital hepatic fibrosis (HP:0002612)1.84053225
127Abnormality of the nasolacrimal system (HP:0000614)1.83936346
128Impulsivity (HP:0100710)1.83626332
129Hypergonadotropic hypogonadism (HP:0000815)1.83473129
130Abnormality of the labia minora (HP:0012880)1.83451031
131Oligohydramnios (HP:0001562)1.83269971
132Abnormality of renal excretion (HP:0011036)1.83084744
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82693620
134Hepatocellular necrosis (HP:0001404)1.82668253
135Absent radius (HP:0003974)1.82050012
136Atelectasis (HP:0100750)1.81969533
137Tachypnea (HP:0002789)1.81838308
138Bony spicule pigmentary retinopathy (HP:0007737)1.81537960
139Genital tract atresia (HP:0001827)1.81444413
140Abnormal biliary tract physiology (HP:0012439)1.81177476
141Bile duct proliferation (HP:0001408)1.81177476
142Aganglionic megacolon (HP:0002251)1.81020137
143Abnormality of DNA repair (HP:0003254)1.80624477
144Absent forearm bone (HP:0003953)1.80370846
145Aplasia involving forearm bones (HP:0009822)1.80370846
146Postaxial foot polydactyly (HP:0001830)1.79664686
147Chronic hepatic failure (HP:0100626)1.79636704
148Lip pit (HP:0100267)1.78932140
149Abnormal lung lobation (HP:0002101)1.78618744
150Prolonged neonatal jaundice (HP:0006579)1.78301881
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.78192183
152Vaginal atresia (HP:0000148)1.77838225
153Mitochondrial inheritance (HP:0001427)1.77600063
154Abnormal sex determination (HP:0012244)1.76639805
155Sex reversal (HP:0012245)1.76639805
156Aplasia/hypoplasia of the uterus (HP:0008684)1.76381270
157Nephronophthisis (HP:0000090)1.75689282
158Optic disc pallor (HP:0000543)1.74617419
159Anencephaly (HP:0002323)1.74288181
160Colon cancer (HP:0003003)1.74167216
161Azoospermia (HP:0000027)1.73254047
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72946721
163Bone marrow hypocellularity (HP:0005528)1.72667773
164Facial cleft (HP:0002006)1.72514041
165Occipital encephalocele (HP:0002085)1.71489583
166Dandy-Walker malformation (HP:0001305)1.70316093
167Dialeptic seizures (HP:0011146)1.69405469
168Tubulointerstitial abnormality (HP:0001969)1.68588824
169Postaxial hand polydactyly (HP:0001162)1.68491195
170Increased serum lactate (HP:0002151)1.68268021
171Absent thumb (HP:0009777)1.67822401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.51889455
2MAP4K23.92039807
3CASK3.64222850
4STK163.10537087
5IRAK33.01863951
6WNK42.91384409
7MKNK22.87987683
8ZAK2.83101054
9ADRBK22.71551534
10GRK12.53354370
11WNK32.35637513
12BRSK22.34494975
13IRAK42.31983293
14TNIK2.20279853
15TAOK32.15517952
16EIF2AK22.07860687
17PLK42.00158505
18NUAK11.91568673
19SRPK11.90264666
20MKNK11.86353556
21BMPR1B1.83618349
22TXK1.80835231
23MAP2K61.74824416
24MAP3K41.72814633
25STK38L1.70776581
26PRPF4B1.69438373
27GRK71.63613834
28YES11.61809748
29NEK61.61594705
30IRAK11.51951745
31DAPK21.47145487
32TTK1.46669237
33PINK11.46483170
34AKT31.45984158
35CDK31.44950524
36BMPR21.40450424
37PBK1.39733143
38MAP3K141.38764347
39IRAK21.38609445
40BLK1.37334957
41MAP2K71.32865211
42SIK31.17984682
43INSRR1.17617501
44VRK11.15341181
45WEE11.15131948
46MUSK1.13581806
47TEC1.12587984
48MAPK71.10168559
49TRIM281.08485727
50NLK1.06040341
51GRK51.05126750
52CHEK20.96961129
53MAPK130.96002414
54CAMKK20.95831309
55MARK10.95705501
56BRD40.92937762
57PKN10.92737217
58CDK80.92306279
59CLK10.92275978
60PNCK0.91103730
61TLK10.90129694
62MAPKAPK30.89829337
63FLT30.88235225
64PAK30.87905780
65CSNK1G20.87867680
66TGFBR10.87649285
67EPHA20.85668709
68CDK120.84092478
69CSNK1G30.83719470
70IKBKB0.83236834
71BCKDK0.82918952
72BRSK10.79324507
73MST40.78598974
74CDK70.78494873
75DYRK20.75347285
76PHKG20.73185461
77PHKG10.73185461
78PRKCG0.71744329
79PLK10.71417861
80PRKCQ0.70014331
81MAPK150.69387685
82BCR0.66563909
83NME10.66344915
84PRKCI0.64890262
85TIE10.64427888
86PRKCE0.58584232
87TNK20.58398234
88EIF2AK30.58312572
89MAP2K20.58172247
90DYRK30.57555975
91PTK2B0.55731290
92EPHA30.54936284
93STK390.52357326
94SGK20.51459686
95ATR0.49787164
96PIK3CA0.49769325
97RPS6KA50.49393441
98ITK0.48521822
99IKBKE0.46967607
100KIT0.46850359
101WNK10.46039962
102ADRBK10.45584121
103EPHA40.45026056
104DYRK1A0.44898713
105VRK20.44288373
106MAP2K40.43747219
107CAMK10.42635619
108CDK90.41805476
109STK240.41472142
110PLK30.41450521
111TAOK20.40186247
112LIMK10.40021090
113PIM20.39328186
114LYN0.39293029
115ERBB30.39213824
116BUB10.38991166
117TAF10.38403646
118CHUK0.37954721
119PLK20.37505301
120OBSCN0.36573951
121STK30.36032160
122STK40.34951685
123CDK190.34406237
124CSNK1A1L0.33024330
125ATM0.32682211
126MAPKAPK50.31427607
127CSNK2A10.31357254
128OXSR10.31202774
129CSNK1A10.30665416
130CSNK1G10.30508571
131TRPM70.30297456
132NTRK30.29540470
133CSNK1D0.29288786
134MAP3K50.29205844
135ACVR1B0.28893374
136PRKD20.28635100
137AURKA0.28105534
138PRKCA0.27826227
139PRKACA0.26837961
140PRKG10.26818334
141PIK3CG0.26677800
142AURKB0.25362213
143NTRK20.23687936
144ERBB40.22682877
145BRAF0.22594307
146CAMK2A0.22246173

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.48224591
2Vitamin B6 metabolism_Homo sapiens_hsa007503.00828185
3Homologous recombination_Homo sapiens_hsa034402.93992631
4Selenocompound metabolism_Homo sapiens_hsa004502.54935463
5Nitrogen metabolism_Homo sapiens_hsa009102.50447630
6Basal transcription factors_Homo sapiens_hsa030222.50295645
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38150070
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.37692400
9RNA polymerase_Homo sapiens_hsa030202.31140680
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26682581
11Butanoate metabolism_Homo sapiens_hsa006502.19458085
12Arachidonic acid metabolism_Homo sapiens_hsa005902.15762682
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13485490
14Non-homologous end-joining_Homo sapiens_hsa034502.08032831
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91744610
16Autoimmune thyroid disease_Homo sapiens_hsa053201.87771385
17Linoleic acid metabolism_Homo sapiens_hsa005911.84155665
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80490388
19Sphingolipid metabolism_Homo sapiens_hsa006001.72541053
20Ether lipid metabolism_Homo sapiens_hsa005651.69156914
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.68820841
22Graft-versus-host disease_Homo sapiens_hsa053321.68379516
23Tryptophan metabolism_Homo sapiens_hsa003801.64015120
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63278250
25Mismatch repair_Homo sapiens_hsa034301.52850763
26Parkinsons disease_Homo sapiens_hsa050121.47651301
27Pyrimidine metabolism_Homo sapiens_hsa002401.47427356
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46313665
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.45622307
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45461522
31Caffeine metabolism_Homo sapiens_hsa002321.44995212
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38342452
33Morphine addiction_Homo sapiens_hsa050321.38057771
34Olfactory transduction_Homo sapiens_hsa047401.37491166
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36283838
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35541345
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35399672
38Nucleotide excision repair_Homo sapiens_hsa034201.34534067
39Propanoate metabolism_Homo sapiens_hsa006401.32742555
40DNA replication_Homo sapiens_hsa030301.30380668
41Allograft rejection_Homo sapiens_hsa053301.29992035
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.29835722
43Peroxisome_Homo sapiens_hsa041461.29396575
44Retinol metabolism_Homo sapiens_hsa008301.27398904
45Phototransduction_Homo sapiens_hsa047441.27020958
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.27014540
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.22008505
48Vitamin digestion and absorption_Homo sapiens_hsa049771.21827334
49Protein export_Homo sapiens_hsa030601.20206175
50Purine metabolism_Homo sapiens_hsa002301.17933612
51Base excision repair_Homo sapiens_hsa034101.17488414
52Nicotine addiction_Homo sapiens_hsa050331.12974271
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08028844
54RNA degradation_Homo sapiens_hsa030181.03860943
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03616021
56Regulation of autophagy_Homo sapiens_hsa041401.03604954
57One carbon pool by folate_Homo sapiens_hsa006701.02376792
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02369277
59Cardiac muscle contraction_Homo sapiens_hsa042601.00312628
60Other glycan degradation_Homo sapiens_hsa005110.99885731
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98518521
62Insulin secretion_Homo sapiens_hsa049110.96984562
63Taste transduction_Homo sapiens_hsa047420.96725771
64Steroid biosynthesis_Homo sapiens_hsa001000.96183605
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95570942
66Hematopoietic cell lineage_Homo sapiens_hsa046400.94985051
67GABAergic synapse_Homo sapiens_hsa047270.94361913
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92740313
69Ovarian steroidogenesis_Homo sapiens_hsa049130.92681094
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90911302
71Primary immunodeficiency_Homo sapiens_hsa053400.89613074
72Circadian entrainment_Homo sapiens_hsa047130.87885068
73Asthma_Homo sapiens_hsa053100.85696415
74p53 signaling pathway_Homo sapiens_hsa041150.83350170
75Serotonergic synapse_Homo sapiens_hsa047260.80360590
76Alzheimers disease_Homo sapiens_hsa050100.79628561
77Herpes simplex infection_Homo sapiens_hsa051680.79283262
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79149743
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78798304
80Rheumatoid arthritis_Homo sapiens_hsa053230.78289911
81Salivary secretion_Homo sapiens_hsa049700.75951630
82Ribosome_Homo sapiens_hsa030100.75010183
83Measles_Homo sapiens_hsa051620.73708160
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73118920
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72790768
86Cell cycle_Homo sapiens_hsa041100.70520737
87Proteasome_Homo sapiens_hsa030500.70211000
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68365159
89Spliceosome_Homo sapiens_hsa030400.67486732
90Glutamatergic synapse_Homo sapiens_hsa047240.67396258
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66010625
92Collecting duct acid secretion_Homo sapiens_hsa049660.66004118
93Fat digestion and absorption_Homo sapiens_hsa049750.65865269
94Histidine metabolism_Homo sapiens_hsa003400.65382886
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64892113
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64053120
97Fatty acid degradation_Homo sapiens_hsa000710.63894258
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.61940694
99Calcium signaling pathway_Homo sapiens_hsa040200.61923643
100Malaria_Homo sapiens_hsa051440.61865639
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59711845
102Sulfur metabolism_Homo sapiens_hsa009200.59506193
103Basal cell carcinoma_Homo sapiens_hsa052170.59482909
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59476859
105Chemical carcinogenesis_Homo sapiens_hsa052040.58853982
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.57759993
107Glycerolipid metabolism_Homo sapiens_hsa005610.57642505
108Type I diabetes mellitus_Homo sapiens_hsa049400.57182272
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.56570153
110Sulfur relay system_Homo sapiens_hsa041220.56425270
111African trypanosomiasis_Homo sapiens_hsa051430.56178171
112beta-Alanine metabolism_Homo sapiens_hsa004100.54090489
113Fatty acid elongation_Homo sapiens_hsa000620.52993835
114Huntingtons disease_Homo sapiens_hsa050160.50987398
115Oxidative phosphorylation_Homo sapiens_hsa001900.50888812
116Metabolic pathways_Homo sapiens_hsa011000.49809018
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49575961
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.45918216
119mRNA surveillance pathway_Homo sapiens_hsa030150.45762193
120Fatty acid metabolism_Homo sapiens_hsa012120.44479126
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42332705
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41458925
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39576988
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38689432
125Melanoma_Homo sapiens_hsa052180.38606178
126Wnt signaling pathway_Homo sapiens_hsa043100.38492188
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38138245
128Circadian rhythm_Homo sapiens_hsa047100.36357922
129ABC transporters_Homo sapiens_hsa020100.35652781
130Tyrosine metabolism_Homo sapiens_hsa003500.32898658
131Dopaminergic synapse_Homo sapiens_hsa047280.32234111
132Hedgehog signaling pathway_Homo sapiens_hsa043400.31827206
133Ras signaling pathway_Homo sapiens_hsa040140.31600105
134RNA transport_Homo sapiens_hsa030130.31310042
135Arginine and proline metabolism_Homo sapiens_hsa003300.30244974
136Staphylococcus aureus infection_Homo sapiens_hsa051500.29724740
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.28640099
138Influenza A_Homo sapiens_hsa051640.27386852
139Mineral absorption_Homo sapiens_hsa049780.26818526

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