EXD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.00436209
2synaptic vesicle maturation (GO:0016188)5.38602016
3synaptic vesicle exocytosis (GO:0016079)5.38279587
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.37060250
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.33076505
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11189407
7regulation of synaptic vesicle exocytosis (GO:2000300)5.09962725
8glutamate secretion (GO:0014047)5.08963801
9neuronal action potential propagation (GO:0019227)5.04023583
10locomotory exploration behavior (GO:0035641)4.98750755
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95301748
12vocalization behavior (GO:0071625)4.91963990
13neuron cell-cell adhesion (GO:0007158)4.84770690
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.81790433
15protein localization to synapse (GO:0035418)4.67436296
16regulation of glutamate receptor signaling pathway (GO:1900449)4.63230184
17glutamate receptor signaling pathway (GO:0007215)4.59353115
18regulation of synaptic vesicle transport (GO:1902803)4.58799698
19synaptic transmission, glutamatergic (GO:0035249)4.41518430
20regulation of neuronal synaptic plasticity (GO:0048168)4.36021700
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.20633525
22neurotransmitter-gated ion channel clustering (GO:0072578)4.15504142
23neuron-neuron synaptic transmission (GO:0007270)4.15041966
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13514050
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.03636191
26regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93567178
27positive regulation of synapse maturation (GO:0090129)3.91308289
28neurotransmitter secretion (GO:0007269)3.87548374
29regulation of synapse structural plasticity (GO:0051823)3.85969839
30dendritic spine morphogenesis (GO:0060997)3.83110385
31neuron recognition (GO:0008038)3.79533135
32exploration behavior (GO:0035640)3.78133703
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77905186
34cellular potassium ion homeostasis (GO:0030007)3.77013828
35regulation of postsynaptic membrane potential (GO:0060078)3.76012401
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.74211274
37positive regulation of membrane potential (GO:0045838)3.72375265
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67148014
39regulation of synaptic plasticity (GO:0048167)3.65106581
40long-term memory (GO:0007616)3.63360010
41regulation of dendritic spine morphogenesis (GO:0061001)3.61308610
42presynaptic membrane assembly (GO:0097105)3.58786033
43long-term synaptic potentiation (GO:0060291)3.54066821
44axonal fasciculation (GO:0007413)3.53227406
45regulation of neurotransmitter secretion (GO:0046928)3.49197395
46transmission of nerve impulse (GO:0019226)3.47103739
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.46224793
48cerebellar Purkinje cell differentiation (GO:0021702)3.46188761
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39789564
50presynaptic membrane organization (GO:0097090)3.38515890
51positive regulation of dendritic spine development (GO:0060999)3.36411448
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31541547
53sodium ion export (GO:0071436)3.31186225
54regulation of dendritic spine development (GO:0060998)3.28867079
55layer formation in cerebral cortex (GO:0021819)3.26945755
56startle response (GO:0001964)3.26934551
57behavioral defense response (GO:0002209)3.25142936
58behavioral fear response (GO:0001662)3.25142936
59positive regulation of neurotransmitter secretion (GO:0001956)3.24566194
60membrane depolarization (GO:0051899)3.24397895
61synaptic vesicle endocytosis (GO:0048488)3.24175559
62membrane hyperpolarization (GO:0060081)3.23900977
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23216151
64neurotransmitter transport (GO:0006836)3.22348204
65regulation of neurotransmitter transport (GO:0051588)3.21626081
66cerebellar granule cell differentiation (GO:0021707)3.21230530
67membrane depolarization during action potential (GO:0086010)3.20681907
68postsynaptic membrane organization (GO:0001941)3.19828269
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18099713
70gamma-aminobutyric acid transport (GO:0015812)3.13902966
71positive regulation of dendritic spine morphogenesis (GO:0061003)3.09007191
72adult walking behavior (GO:0007628)3.07457900
73learning (GO:0007612)3.07358249
74regulation of vesicle fusion (GO:0031338)3.07327225
75neuronal ion channel clustering (GO:0045161)3.05051912
76fear response (GO:0042596)3.04129626
77mechanosensory behavior (GO:0007638)3.03827234
78positive regulation of neurotransmitter transport (GO:0051590)3.03212448
79auditory behavior (GO:0031223)3.02194846
80neuromuscular process controlling posture (GO:0050884)3.01778216
81neuromuscular process controlling balance (GO:0050885)3.00768914
82regulation of synapse maturation (GO:0090128)2.99297770
83behavioral response to cocaine (GO:0048148)2.98197871
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97974227
85regulation of synaptic transmission (GO:0050804)2.97724118
86regulation of neurotransmitter levels (GO:0001505)2.94556674
87dendritic spine organization (GO:0097061)2.94052615
88response to histamine (GO:0034776)2.93471250
89nerve growth factor signaling pathway (GO:0038180)2.93151141
90regulation of respiratory system process (GO:0044065)2.92962829
91dendrite morphogenesis (GO:0048813)2.92443756
92regulation of glutamate secretion (GO:0014048)2.91962010
93synaptic transmission (GO:0007268)2.90268095
94innervation (GO:0060384)2.89044772
95calcium ion-dependent exocytosis (GO:0017156)2.88457054
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88270969
97regulation of voltage-gated calcium channel activity (GO:1901385)2.83750160
98positive regulation of synaptic transmission (GO:0050806)2.83575995
99neuromuscular process (GO:0050905)2.82047022
100long term synaptic depression (GO:0060292)2.81605086
101pyrimidine nucleobase catabolic process (GO:0006208)2.80948058
102asymmetric protein localization (GO:0008105)2.52861009
103response to auditory stimulus (GO:0010996)2.42579749
104nonmotile primary cilium assembly (GO:0035058)2.42364611
105Golgi transport vesicle coating (GO:0048200)2.41932486
106COPI coating of Golgi vesicle (GO:0048205)2.41932486
107positive regulation of synapse assembly (GO:0051965)2.39078489
108calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37614268
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.27926909
110cerebellar Purkinje cell layer development (GO:0021680)2.20590259
111intraciliary transport (GO:0042073)2.19218146
112peptidyl-cysteine modification (GO:0018198)2.15653476
113neurotransmitter catabolic process (GO:0042135)2.15608347
114apical protein localization (GO:0045176)2.10917348
115nucleobase catabolic process (GO:0046113)2.10601815
116ephrin receptor signaling pathway (GO:0048013)2.09892003
117axon extension (GO:0048675)2.09543210
118cholesterol biosynthetic process (GO:0006695)2.09461935
119regulation of synapse assembly (GO:0051963)2.08367658
120establishment of tissue polarity (GO:0007164)2.08246988
121establishment of planar polarity (GO:0001736)2.08246988
122synapse assembly (GO:0007416)2.07819583
123C4-dicarboxylate transport (GO:0015740)2.07505426
124cerebral cortex radially oriented cell migration (GO:0021799)2.06760306
125cochlea development (GO:0090102)2.05138463
126establishment of mitochondrion localization (GO:0051654)2.04016676
127mating behavior (GO:0007617)2.01086449
128cell communication involved in cardiac conduction (GO:0086065)1.99310629
129negative regulation of dendrite morphogenesis (GO:0050774)1.97743563
130biotin metabolic process (GO:0006768)1.96747117
131regulation of Rac GTPase activity (GO:0032314)1.94355164
132negative regulation of cytosolic calcium ion concentration (GO:0051481)1.93983924
133axon cargo transport (GO:0008088)1.93924278
134sterol biosynthetic process (GO:0016126)1.91092451
135retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.90514800
136neuron projection extension involved in neuron projection guidance (GO:1902284)1.90037794
137axon extension involved in axon guidance (GO:0048846)1.90037794
138otic vesicle formation (GO:0030916)1.89910285
139cytoskeleton-dependent intracellular transport (GO:0030705)1.89342357
140hippocampus development (GO:0021766)1.88761562
141L-serine transport (GO:0015825)1.88094458
142positive regulation of mitochondrial fission (GO:0090141)1.88007625
143microtubule severing (GO:0051013)1.86736869
144cellular sodium ion homeostasis (GO:0006883)1.85354213
145axonemal dynein complex assembly (GO:0070286)1.85236677
146fatty acid elongation (GO:0030497)1.84079151
147synapse organization (GO:0050808)1.82850196
148microtubule-based transport (GO:0010970)1.82386073
149neuron projection extension (GO:1990138)1.82385655
150amino acid salvage (GO:0043102)1.81697279
151L-methionine salvage (GO:0071267)1.81697279
152L-methionine biosynthetic process (GO:0071265)1.81697279
153cell communication by electrical coupling (GO:0010644)1.81558886
154regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)1.81322024
155detection of calcium ion (GO:0005513)1.81284734
156righting reflex (GO:0060013)1.79849709
157paraxial mesoderm development (GO:0048339)1.78996110
158homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)1.77031678
159lipid particle organization (GO:0034389)1.76799504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.86382115
2GBX2_23144817_ChIP-Seq_PC3_Human3.99321747
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.49785882
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95724254
5REST_21632747_ChIP-Seq_MESCs_Mouse2.93219252
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.87395481
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85064556
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78329031
9DROSHA_22980978_ChIP-Seq_HELA_Human2.53068647
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.45949588
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43054938
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43054938
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40915099
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37072657
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36888239
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33540784
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.26827458
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23495368
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15950145
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.12603387
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11532013
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11355117
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09857253
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.09516817
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09039933
26TAF15_26573619_Chip-Seq_HEK293_Human1.99424366
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98131347
28AR_21572438_ChIP-Seq_LNCaP_Human1.95581152
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.95190373
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92000138
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91610021
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87551367
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83552401
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78833365
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.64834902
36SMAD4_21799915_ChIP-Seq_A2780_Human1.63730366
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60817122
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60682922
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59336028
40ZNF274_21170338_ChIP-Seq_K562_Hela1.57098638
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44286771
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41230008
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41012331
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40306112
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38616721
46P300_19829295_ChIP-Seq_ESCs_Human1.38394425
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.38224170
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37608324
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37374930
50STAT3_23295773_ChIP-Seq_U87_Human1.36065945
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32488526
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.31982089
53FUS_26573619_Chip-Seq_HEK293_Human1.31966928
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.31942008
55ZNF263_19887448_ChIP-Seq_K562_Human1.31815453
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30645782
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.30024987
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29988185
59AR_25329375_ChIP-Seq_VCAP_Human1.29053342
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23426714
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23100078
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20312117
63IGF1R_20145208_ChIP-Seq_DFB_Human1.20303433
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20168586
65AR_19668381_ChIP-Seq_PC3_Human1.20141076
66* TCF4_23295773_ChIP-Seq_U87_Human1.19810277
67EWS_26573619_Chip-Seq_HEK293_Human1.18013365
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17713033
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.16880735
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16005835
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15699484
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15646243
73TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15484904
74TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15374288
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.15022308
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14621726
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11694662
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11164055
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.11059873
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10734804
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10734804
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10675727
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10182341
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10033854
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.09919846
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.09523275
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09239126
88CLOCK_20551151_ChIP-Seq_293T_Human1.08964602
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07837202
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07401553
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07319739
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07319739
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.06795596
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05850778
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05307848
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.05047988
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.03384879
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03006704
99RNF2_27304074_Chip-Seq_NSC_Mouse1.02666831
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02542690
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01896950
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.01537710
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00195441
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99844913
105PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99821245
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98271189
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98204758
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97605076
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96998055
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96834701
111POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95710408
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94442129
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.94383031
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93988590
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93216671
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93162609
117AHR_22903824_ChIP-Seq_MCF-7_Human0.92481315
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.91848048
119SOX9_26525672_Chip-Seq_HEART_Mouse0.91647443
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90928403
121ER_23166858_ChIP-Seq_MCF-7_Human0.90876636
122RUNX2_22187159_ChIP-Seq_PCA_Human0.90621789
123* TET1_21490601_ChIP-Seq_MESCs_Mouse0.90168561
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90140066
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89201057
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.88606428
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88565038
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87853566
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.87428250
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.87388923
131TP53_18474530_ChIP-ChIP_U2OS_Human0.87183724
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87165173
133* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87034404
134POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86613686
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86134762
136TP53_16413492_ChIP-PET_HCT116_Human0.85983125
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85671344
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82057194
139ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81042051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.50126585
2MP0003880_abnormal_central_pattern5.15686550
3MP0003635_abnormal_synaptic_transmissio4.06521820
4MP0004270_analgesia3.77755441
5MP0009745_abnormal_behavioral_response3.35938760
6MP0002063_abnormal_learning/memory/cond3.22505985
7MP0002064_seizures3.16650712
8MP0009046_muscle_twitch2.96308908
9MP0002272_abnormal_nervous_system2.85219259
10MP0002822_catalepsy2.81057317
11MP0002572_abnormal_emotion/affect_behav2.73579033
12MP0005423_abnormal_somatic_nervous2.65393985
13MP0001486_abnormal_startle_reflex2.64693091
14MP0001968_abnormal_touch/_nociception2.54460745
15MP0002734_abnormal_mechanical_nocicepti2.38041359
16MP0003329_amyloid_beta_deposits2.32866033
17MP0001501_abnormal_sleep_pattern2.10829880
18MP0008569_lethality_at_weaning2.06898247
19MP0002735_abnormal_chemical_nociception2.06056816
20MP0002067_abnormal_sensory_capabilities1.93669239
21MP0002736_abnormal_nociception_after1.90810934
22MP0001440_abnormal_grooming_behavior1.90555533
23MP0000778_abnormal_nervous_system1.85671270
24MP0000566_synostosis1.76594419
25MP0002184_abnormal_innervation1.73499678
26MP0001970_abnormal_pain_threshold1.70910299
27MP0004885_abnormal_endolymph1.70279018
28MP0004811_abnormal_neuron_physiology1.69083231
29MP0004924_abnormal_behavior1.68930663
30MP0005386_behavior/neurological_phenoty1.68930663
31MP0002733_abnormal_thermal_nociception1.67337031
32MP0001502_abnormal_circadian_rhythm1.67111650
33MP0005623_abnormal_meninges_morphology1.65540377
34MP0009780_abnormal_chondrocyte_physiolo1.63899222
35MP0003879_abnormal_hair_cell1.62713651
36MP0002557_abnormal_social/conspecific_i1.62220414
37MP0001529_abnormal_vocalization1.62039533
38MP0005187_abnormal_penis_morphology1.60828068
39MP0001984_abnormal_olfaction1.57017388
40MP0005551_abnormal_eye_electrophysiolog1.56595074
41MP0000579_abnormal_nail_morphology1.56556113
42MP0000955_abnormal_spinal_cord1.54566757
43MP0002882_abnormal_neuron_morphology1.53574213
44MP0005646_abnormal_pituitary_gland1.53225114
45MP0004145_abnormal_muscle_electrophysio1.52437047
46MP0003121_genomic_imprinting1.50063595
47MP0000537_abnormal_urethra_morphology1.49043151
48MP0002066_abnormal_motor_capabilities/c1.45302230
49MP0002909_abnormal_adrenal_gland1.40512661
50MP0000762_abnormal_tongue_morphology1.39672218
51MP0001905_abnormal_dopamine_level1.38304269
52MP0001299_abnormal_eye_distance/1.33350497
53MP0003633_abnormal_nervous_system1.32868806
54MP0002229_neurodegeneration1.30936729
55MP0000920_abnormal_myelination1.30224677
56MP0003631_nervous_system_phenotype1.27719571
57MP0004272_abnormal_basement_membrane1.25655642
58MP0002233_abnormal_nose_morphology1.25315114
59MP0004742_abnormal_vestibular_system1.24856383
60MP0006292_abnormal_olfactory_placode1.24475069
61MP0003787_abnormal_imprinting1.21827474
62MP0003890_abnormal_embryonic-extraembry1.21001115
63MP0008789_abnormal_olfactory_epithelium1.20498011
64MP0003937_abnormal_limbs/digits/tail_de1.20045926
65MP0002152_abnormal_brain_morphology1.18059624
66MP0004142_abnormal_muscle_tone1.16247466
67MP0000751_myopathy1.15536701
68MP0001188_hyperpigmentation1.14410139
69MP0006276_abnormal_autonomic_nervous1.14291892
70MP0003632_abnormal_nervous_system1.12860367
71MP0002102_abnormal_ear_morphology1.09517295
72MP0003941_abnormal_skin_development1.08421030
73MP0004858_abnormal_nervous_system1.04727642
74MP0002638_abnormal_pupillary_reflex1.04663735
75MP0000049_abnormal_middle_ear1.04569477
76MP0005645_abnormal_hypothalamus_physiol1.01500210
77MP0010368_abnormal_lymphatic_system1.00262352
78MP0001485_abnormal_pinna_reflex0.99372147
79MP0003755_abnormal_palate_morphology0.99153271
80MP0006072_abnormal_retinal_apoptosis0.98633378
81MP0001293_anophthalmia0.98325784
82MP0001963_abnormal_hearing_physiology0.98095004
83MP0005248_abnormal_Harderian_gland0.97850339
84MP0003942_abnormal_urinary_system0.96015813
85MP0004043_abnormal_pH_regulation0.95531530
86MP0002069_abnormal_eating/drinking_beha0.95426984
87MP0003634_abnormal_glial_cell0.94819324
88MP0010386_abnormal_urinary_bladder0.94329355
89MP0003315_abnormal_perineum_morphology0.93835621
90MP0002752_abnormal_somatic_nervous0.92640543
91MP0000604_amyloidosis0.92219847
92MP0002090_abnormal_vision0.92205673
93MP0003690_abnormal_glial_cell0.88564691
94MP0002697_abnormal_eye_size0.88194735
95MP0004133_heterotaxia0.87870096
96MP0005410_abnormal_fertilization0.87170306
97MP0003123_paternal_imprinting0.86967143
98MP0002160_abnormal_reproductive_system0.86914696
99MP0010030_abnormal_orbit_morphology0.85658755
100MP0003935_abnormal_craniofacial_develop0.84767371
101MP0002938_white_spotting0.83998194
102MP0008961_abnormal_basal_metabolism0.83866968
103MP0000631_abnormal_neuroendocrine_gland0.82760943
104MP0001177_atelectasis0.82627320
105MP0003119_abnormal_digestive_system0.81601907
106MP0005253_abnormal_eye_physiology0.80055659
107MP0008872_abnormal_physiological_respon0.78896959
108MP0004233_abnormal_muscle_weight0.78779365
109MP0004085_abnormal_heartbeat0.78269789
110MP0000462_abnormal_digestive_system0.78053357
111MP0000747_muscle_weakness0.77964300
112MP0000647_abnormal_sebaceous_gland0.77796957
113MP0009703_decreased_birth_body0.76290079
114MP0008874_decreased_physiological_sensi0.76145096
115MP0002116_abnormal_craniofacial_bone0.76004546
116MP0003868_abnormal_feces_composition0.75964681
117MP0002084_abnormal_developmental_patter0.75908926
118MP0003698_abnormal_male_reproductive0.75530822
119MP0000534_abnormal_ureter_morphology0.74395119
120MP0003122_maternal_imprinting0.74337728
121MP0004215_abnormal_myocardial_fiber0.73257798
122MP0003385_abnormal_body_wall0.73014600
123MP0010234_abnormal_vibrissa_follicle0.72921900
124MP0002837_dystrophic_cardiac_calcinosis0.72590548
125MP0000013_abnormal_adipose_tissue0.72028784
126MP0008877_abnormal_DNA_methylation0.71234310
127MP0005535_abnormal_body_temperature0.70997601
128MP0002081_perinatal_lethality0.69898157
129MP0008932_abnormal_embryonic_tissue0.69733423
130MP0001270_distended_abdomen0.68757141
131MP0002653_abnormal_ependyma_morphology0.68625152
132MP0003861_abnormal_nervous_system0.68551356
133MP0000427_abnormal_hair_cycle0.68093625
134MP0002234_abnormal_pharynx_morphology0.67437718
135MP0000026_abnormal_inner_ear0.67184800
136MP0009672_abnormal_birth_weight0.66614871
137MP0005499_abnormal_olfactory_system0.64930657
138MP0005394_taste/olfaction_phenotype0.64930657
139MP0001664_abnormal_digestion0.63347659
140MP0004036_abnormal_muscle_relaxation0.61548955
141MP0003137_abnormal_impulse_conducting0.60009407
142MP0003183_abnormal_peptide_metabolism0.59728879
143MP0010769_abnormal_survival0.59476167
144MP0003075_altered_response_to0.59080883
145MP0002082_postnatal_lethality0.57434095
146MP0010770_preweaning_lethality0.57434095

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.63302812
2Myokymia (HP:0002411)5.80232759
3Focal seizures (HP:0007359)5.27539512
4Epileptic encephalopathy (HP:0200134)5.18298857
5Atonic seizures (HP:0010819)4.67270256
6Febrile seizures (HP:0002373)4.42769562
7Visual hallucinations (HP:0002367)4.29284009
8Hyperventilation (HP:0002883)3.95593126
9Absence seizures (HP:0002121)3.93265501
10Dialeptic seizures (HP:0011146)3.76638410
11Broad-based gait (HP:0002136)3.75303540
12Progressive cerebellar ataxia (HP:0002073)3.59128082
13Ankle clonus (HP:0011448)3.56947282
14Gaze-evoked nystagmus (HP:0000640)3.54458219
15Poor eye contact (HP:0000817)3.46159682
16Action tremor (HP:0002345)3.45845841
17Generalized tonic-clonic seizures (HP:0002069)3.41998879
18Truncal ataxia (HP:0002078)3.40989628
19Supranuclear gaze palsy (HP:0000605)3.36258719
20Dysmetria (HP:0001310)3.25260313
21Impaired vibration sensation in the lower limbs (HP:0002166)3.20034704
22Dysdiadochokinesis (HP:0002075)3.17794986
23Impaired social interactions (HP:0000735)3.09547671
24Abnormal social behavior (HP:0012433)3.09547671
25Spastic gait (HP:0002064)2.97257686
26Urinary urgency (HP:0000012)2.95885496
27Abnormality of the lower motor neuron (HP:0002366)2.94476150
28Depression (HP:0000716)2.92240589
29Abnormality of the corticospinal tract (HP:0002492)2.89977685
30Scanning speech (HP:0002168)2.85584482
31Excessive salivation (HP:0003781)2.85504879
32Drooling (HP:0002307)2.85504879
33Postural instability (HP:0002172)2.83927291
34Neurofibrillary tangles (HP:0002185)2.83461219
35Urinary bladder sphincter dysfunction (HP:0002839)2.83154980
36Amblyopia (HP:0000646)2.82499222
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.75876332
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.75876332
39Epileptiform EEG discharges (HP:0011182)2.75781349
40Progressive inability to walk (HP:0002505)2.74198665
41Hemiparesis (HP:0001269)2.67779882
42Nephrogenic diabetes insipidus (HP:0009806)2.66226676
43Impaired smooth pursuit (HP:0007772)2.66050281
44Insidious onset (HP:0003587)2.61308349
45Termporal pattern (HP:0011008)2.61308349
46EEG with generalized epileptiform discharges (HP:0011198)2.58678661
47Cerebral inclusion bodies (HP:0100314)2.56282209
48Inability to walk (HP:0002540)2.56211780
49Intention tremor (HP:0002080)2.53671737
50Megalencephaly (HP:0001355)2.46728931
51Anxiety (HP:0000739)2.45962659
52Abnormality of dentin (HP:0010299)2.42468520
53Congenital primary aphakia (HP:0007707)2.41469122
54Hypsarrhythmia (HP:0002521)2.40302142
55Abnormality of ocular smooth pursuit (HP:0000617)2.38787462
56Tubulointerstitial nephritis (HP:0001970)2.35969270
57Clumsiness (HP:0002312)2.35516744
58Impaired vibratory sensation (HP:0002495)2.34121427
59Absent speech (HP:0001344)2.34101067
60Generalized myoclonic seizures (HP:0002123)2.30509514
61Lower limb muscle weakness (HP:0007340)2.30163654
62Clonus (HP:0002169)2.26887356
63Bradykinesia (HP:0002067)2.23867051
64Stereotypic behavior (HP:0000733)2.23267701
65Medial flaring of the eyebrow (HP:0010747)2.22093502
66Gait ataxia (HP:0002066)2.21612480
67Fetal akinesia sequence (HP:0001989)2.20937892
68Abnormal eating behavior (HP:0100738)2.18293935
69Mutism (HP:0002300)2.16169878
70Retinal dysplasia (HP:0007973)2.15805089
71Genetic anticipation (HP:0003743)2.15768240
72Thickened helices (HP:0000391)2.13715865
73Delusions (HP:0000746)2.09729942
74Polyphagia (HP:0002591)2.08631641
75Abnormality of glycolysis (HP:0004366)2.06887919
76Increased serum pyruvate (HP:0003542)2.06646415
77Dysmetric saccades (HP:0000641)2.02526884
78Exercise-induced myalgia (HP:0003738)2.01953488
79Torticollis (HP:0000473)2.01570858
80Vaginal atresia (HP:0000148)2.01458512
81Abnormality of binocular vision (HP:0011514)2.00578869
82Diplopia (HP:0000651)2.00578869
83Proximal tubulopathy (HP:0000114)2.00569531
84Central scotoma (HP:0000603)1.98833850
85Genital tract atresia (HP:0001827)1.98312059
86Protruding tongue (HP:0010808)1.96557064
87Status epilepticus (HP:0002133)1.92450056
88Focal dystonia (HP:0004373)1.91394573
89Occipital encephalocele (HP:0002085)1.89909017
90Hemiplegia (HP:0002301)1.89743635
91Pheochromocytoma (HP:0002666)1.88649160
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88466385
93Blue irides (HP:0000635)1.86692744
94Limb dystonia (HP:0002451)1.86520988
95Congenital stationary night blindness (HP:0007642)1.84793399
96Rigidity (HP:0002063)1.84339159
97Abnormality of the dental root (HP:0006486)1.82509413
98Taurodontia (HP:0000679)1.82509413
99Abnormality of permanent molar morphology (HP:0011071)1.82509413
100Abnormality of salivation (HP:0100755)1.82031688
101Abnormality of saccadic eye movements (HP:0000570)1.80765444
102Gait imbalance (HP:0002141)1.77924896
103Incomplete penetrance (HP:0003829)1.77899506
104Type II lissencephaly (HP:0007260)1.77792229
105Abnormal respiratory motile cilium morphology (HP:0005938)1.77243293
106Abnormal respiratory epithelium morphology (HP:0012253)1.77243293
107Absent/shortened dynein arms (HP:0200106)1.76897755
108Dynein arm defect of respiratory motile cilia (HP:0012255)1.76897755
109Shoulder girdle muscle weakness (HP:0003547)1.76834498
110Poor speech (HP:0002465)1.75830223
111Tetraplegia (HP:0002445)1.75285617
112CNS hypomyelination (HP:0003429)1.74880798
113Cortical visual impairment (HP:0100704)1.72451594
114Abnormality of molar (HP:0011077)1.71964714
115Abnormality of molar morphology (HP:0011070)1.71964714
116Limb ataxia (HP:0002070)1.70978024
117Cerebral hypomyelination (HP:0006808)1.70189756
118Psychosis (HP:0000709)1.70074373
119Widely spaced teeth (HP:0000687)1.69611692
120Poor coordination (HP:0002370)1.69294477
121Gonadotropin excess (HP:0000837)1.68279488
122Specific learning disability (HP:0001328)1.67484510
123Severe global developmental delay (HP:0011344)1.67006872
124Craniofacial dystonia (HP:0012179)1.66873140
125Exercise-induced muscle cramps (HP:0003710)1.64967065
126Split foot (HP:0001839)1.64167702
127Papillary thyroid carcinoma (HP:0002895)1.62510705
128Volvulus (HP:0002580)1.60895232
129Cortical dysplasia (HP:0002539)1.59307714
130Alacrima (HP:0000522)1.57676294
131Abnormality of the labia minora (HP:0012880)1.57617128
132Decreased testicular size (HP:0008734)1.57404729
133Open mouth (HP:0000194)1.51738951
134Right ventricular cardiomyopathy (HP:0011663)1.50791650
135Aplasia/Hypoplasia of the lens (HP:0008063)1.50191746
136Decreased lacrimation (HP:0000633)1.49389803
137Intestinal atresia (HP:0011100)1.49189183
138Neoplasm of the oral cavity (HP:0100649)1.48847003
139Hepatoblastoma (HP:0002884)1.48661490
140Poor suck (HP:0002033)1.48308717
141Abnormality of the dental pulp (HP:0006479)1.45633635
142Hypoplastic pelvis (HP:0008839)1.45448939
143Buphthalmos (HP:0000557)1.43153741
144Failure to thrive in infancy (HP:0001531)1.43048680
145Broad foot (HP:0001769)1.43012033
146Hyperglycinemia (HP:0002154)1.42292821
147Renal tubular acidosis (HP:0001947)1.41904885
148Hip dysplasia (HP:0001385)1.39508248
149Medulloblastoma (HP:0002885)1.38875402
150Postnatal microcephaly (HP:0005484)1.38210903
151Unilateral renal agenesis (HP:0000122)1.37407066
152Astrocytoma (HP:0009592)1.36922526
153Abnormality of the astrocytes (HP:0100707)1.36922526
154Osteomalacia (HP:0002749)1.36481152
155Atrophic scars (HP:0001075)1.34990578
156Cutaneous finger syndactyly (HP:0010554)1.34696455
157Labial hypoplasia (HP:0000066)1.34368382
158High anterior hairline (HP:0009890)1.34250669
159Micropenis (HP:0000054)1.33707985
160Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.32649261
161Vertebral hypoplasia (HP:0008417)1.32649261
162Hypoplastic female external genitalia (HP:0012815)1.32527701
163Postaxial hand polydactyly (HP:0001162)1.32158543
164Lissencephaly (HP:0001339)1.31425348
165Bronchomalacia (HP:0002780)1.30822824
166Increased nuchal translucency (HP:0010880)1.29674395
167Aplasia/Hypoplasia of the fibula (HP:0006492)1.29669822
168Akinesia (HP:0002304)1.29523215
169Pterygium (HP:0001059)1.29204367
170Neoplasm of the peripheral nervous system (HP:0100007)1.28475214
171Dental crowding (HP:0000678)1.28324644
172Renal dysplasia (HP:0000110)1.27894049
173Median cleft lip (HP:0000161)1.27058587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.71888010
2NTRK33.98588718
3PRPF4B3.87966939
4MAP3K93.18316894
5MAP3K42.75902476
6DAPK22.58785328
7TNIK2.53823071
8MAP2K72.41547959
9PAK62.16102569
10PRKD32.14639678
11MARK12.12429812
12MINK12.11684163
13CDK192.06920308
14KSR11.98646629
15CASK1.93813508
16TSSK61.92068409
17KSR21.80737952
18BRSK21.76176626
19NTRK21.73839605
20DAPK11.70611952
21CSNK1G11.66724636
22OXSR11.61195972
23PNCK1.58150615
24MAP2K41.57580919
25CDK51.55903146
26CAMKK21.46676398
27CAMKK11.45839219
28PBK1.45450979
29CSNK1G31.43830957
30RIPK41.43728460
31MAP3K131.40949483
32PLK21.40818260
33MAPK131.35687166
34PKN21.29833116
35MAP3K121.27426291
36STK391.25092644
37MET1.25047621
38NTRK11.24557516
39UHMK11.24394101
40ARAF1.20102523
41SCYL21.19128935
42PHKG11.18451406
43PHKG21.18451406
44SIK21.17028232
45LIMK11.16376885
46ERBB31.16151759
47SGK4941.16134361
48SGK2231.16134361
49EPHA21.13039826
50CCNB11.12080025
51LATS11.11862035
52EPHB21.11237323
53PRKCG1.10770190
54MAP4K21.10238033
55CAMK2B1.06861102
56CAMK11.03846641
57PINK10.98739155
58LATS20.98286012
59STK380.96894959
60TESK10.96377144
61STK160.96012331
62CAMK2A0.92657870
63FER0.92642049
64TRIM280.92389252
65PTK2B0.91677961
66DYRK20.90874709
67CDK180.87170472
68AKT30.86411705
69PTK20.85485014
70TTK0.84696496
71CDK150.84494310
72MST1R0.84177693
73TYRO30.84131001
74WEE10.84101767
75CDK140.81451329
76STK110.80374306
77RAF10.79434082
78NME10.79002743
79GRK50.78804363
80FES0.77212625
81MAPK150.73999469
82DYRK1A0.73894515
83CDK11A0.73845205
84MAPKAPK50.72146038
85CSNK1G20.71769779
86SGK10.71433956
87PAK30.70701504
88TAOK20.70322958
89PRKCH0.69889586
90MARK20.69778315
91MAP3K70.67736337
92FGFR10.67249385
93TNK20.66918165
94BCR0.66618286
95INSRR0.66262756
96BMPR20.64880201
97STK38L0.63937695
98PDGFRA0.63855598
99MUSK0.63086691
100SRPK10.62360624
101RPS6KB10.61736541
102SGK20.61633882
103PLK30.61180816
104EIF2AK30.60453264
105LMTK20.59088595
106BRAF0.58149369
107CAMK2D0.56032702
108ROCK20.55279366
109SGK30.54692437
110CSNK1E0.54314648
111CAMK1G0.52935546
112WNK10.52645497
113FLT30.51919386
114ERBB40.50881129
115PDK10.50671259
116MAPK100.50632558
117RIPK10.50495443
118PDPK10.50204322
119WNK40.50031272
120PRKAA10.49976273
121MAP3K20.49358457
122RPS6KA30.48822410
123CSNK1A1L0.48435634
124PLK40.47984446
125WNK30.47415037
126VRK20.47349102
127PLK10.46989457
128FGFR20.45527049
129SIK30.44904250
130PDK30.44696460
131PDK40.44696460
132NEK10.44521823
133CAMK40.44393238
134TAOK10.44017946
135NEK60.43500119
136TIE10.43207384
137BRSK10.40427201
138MAP3K10.40373730
139MAPK120.39436559
140CAMK2G0.38253277
141PRKCE0.36509422
142CDK30.34648526

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93491331
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18245829
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86246704
4Long-term potentiation_Homo sapiens_hsa047202.82742551
5Glutamatergic synapse_Homo sapiens_hsa047242.82310673
6Olfactory transduction_Homo sapiens_hsa047402.81829966
7Circadian entrainment_Homo sapiens_hsa047132.81647865
8GABAergic synapse_Homo sapiens_hsa047272.75868545
9Amphetamine addiction_Homo sapiens_hsa050312.60272190
10Morphine addiction_Homo sapiens_hsa050322.57518586
11Dopaminergic synapse_Homo sapiens_hsa047282.26670296
12Salivary secretion_Homo sapiens_hsa049702.14956383
13Insulin secretion_Homo sapiens_hsa049112.06028064
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92440226
15Fatty acid elongation_Homo sapiens_hsa000621.89854670
16Steroid biosynthesis_Homo sapiens_hsa001001.89447130
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88844152
18Taste transduction_Homo sapiens_hsa047421.86839808
19Long-term depression_Homo sapiens_hsa047301.80816221
20Oxytocin signaling pathway_Homo sapiens_hsa049211.80715212
21Cholinergic synapse_Homo sapiens_hsa047251.80659790
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79645311
23Serotonergic synapse_Homo sapiens_hsa047261.78156390
24Gastric acid secretion_Homo sapiens_hsa049711.77525781
25Renin secretion_Homo sapiens_hsa049241.76705037
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75417587
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69223921
28Cocaine addiction_Homo sapiens_hsa050301.67872906
29Calcium signaling pathway_Homo sapiens_hsa040201.66641989
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65048641
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54680361
32Propanoate metabolism_Homo sapiens_hsa006401.53692771
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43780212
34Collecting duct acid secretion_Homo sapiens_hsa049661.43456666
35Protein export_Homo sapiens_hsa030601.42428693
36GnRH signaling pathway_Homo sapiens_hsa049121.36182779
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34041739
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33011442
39Butanoate metabolism_Homo sapiens_hsa006501.32960052
40Gap junction_Homo sapiens_hsa045401.29925745
41Phototransduction_Homo sapiens_hsa047441.29481430
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29008236
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26972148
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26382872
45cAMP signaling pathway_Homo sapiens_hsa040241.24925449
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24212940
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23220540
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21021414
49Arginine and proline metabolism_Homo sapiens_hsa003301.20774195
50Axon guidance_Homo sapiens_hsa043601.17836651
51Fatty acid metabolism_Homo sapiens_hsa012121.16378322
52Circadian rhythm_Homo sapiens_hsa047101.13488799
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12162239
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09555326
55Pyruvate metabolism_Homo sapiens_hsa006201.06465933
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05606623
57Hippo signaling pathway_Homo sapiens_hsa043901.03808361
58ErbB signaling pathway_Homo sapiens_hsa040121.03033018
59Oocyte meiosis_Homo sapiens_hsa041140.99684474
60beta-Alanine metabolism_Homo sapiens_hsa004100.97585378
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97070358
62Type II diabetes mellitus_Homo sapiens_hsa049300.96889054
63Cardiac muscle contraction_Homo sapiens_hsa042600.96873625
64Estrogen signaling pathway_Homo sapiens_hsa049150.96871912
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.95284079
66Biosynthesis of amino acids_Homo sapiens_hsa012300.94826455
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94772968
68Hedgehog signaling pathway_Homo sapiens_hsa043400.94614574
69Glioma_Homo sapiens_hsa052140.92444759
70Carbon metabolism_Homo sapiens_hsa012000.91221613
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91051090
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90771248
73Pancreatic secretion_Homo sapiens_hsa049720.90707790
74Melanogenesis_Homo sapiens_hsa049160.90303858
75Basal cell carcinoma_Homo sapiens_hsa052170.89113584
76Vibrio cholerae infection_Homo sapiens_hsa051100.84011113
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82203134
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.80759680
79Choline metabolism in cancer_Homo sapiens_hsa052310.79293331
80MAPK signaling pathway_Homo sapiens_hsa040100.77053532
81Phenylalanine metabolism_Homo sapiens_hsa003600.76773080
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75204232
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75097287
84Dorso-ventral axis formation_Homo sapiens_hsa043200.70605239
85N-Glycan biosynthesis_Homo sapiens_hsa005100.70370858
86Dilated cardiomyopathy_Homo sapiens_hsa054140.69675041
87Peroxisome_Homo sapiens_hsa041460.69266855
88Adherens junction_Homo sapiens_hsa045200.68664596
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67513974
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67358089
91Glucagon signaling pathway_Homo sapiens_hsa049220.67047226
92Inositol phosphate metabolism_Homo sapiens_hsa005620.66793305
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.66061134
94RNA polymerase_Homo sapiens_hsa030200.65496804
95VEGF signaling pathway_Homo sapiens_hsa043700.64892949
96RNA transport_Homo sapiens_hsa030130.64852975
97AMPK signaling pathway_Homo sapiens_hsa041520.64810430
98Nitrogen metabolism_Homo sapiens_hsa009100.64087628
99Regulation of autophagy_Homo sapiens_hsa041400.62616260
100Ras signaling pathway_Homo sapiens_hsa040140.60175922
101mRNA surveillance pathway_Homo sapiens_hsa030150.59541520
102Thyroid hormone synthesis_Homo sapiens_hsa049180.59461143
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59398063
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59003388
105Sphingolipid metabolism_Homo sapiens_hsa006000.58923631
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56893812
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56807820
108Fatty acid degradation_Homo sapiens_hsa000710.56030478
109Arginine biosynthesis_Homo sapiens_hsa002200.55751258
110Vitamin B6 metabolism_Homo sapiens_hsa007500.55624666
111Folate biosynthesis_Homo sapiens_hsa007900.55352663
112Renal cell carcinoma_Homo sapiens_hsa052110.54855183
113Tyrosine metabolism_Homo sapiens_hsa003500.53470273
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.53108572
115ECM-receptor interaction_Homo sapiens_hsa045120.52564974
116Alcoholism_Homo sapiens_hsa050340.52252812
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52048389
118Glutathione metabolism_Homo sapiens_hsa004800.50520962
119Huntingtons disease_Homo sapiens_hsa050160.50410195
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.49935971
121Parkinsons disease_Homo sapiens_hsa050120.49691452
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49448928
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.49153511
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49008348
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.48057670
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47013740
127TGF-beta signaling pathway_Homo sapiens_hsa043500.46317951
128Endocytosis_Homo sapiens_hsa041440.46151521
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45883228
130Wnt signaling pathway_Homo sapiens_hsa043100.45634638
131Rap1 signaling pathway_Homo sapiens_hsa040150.45389008
132Base excision repair_Homo sapiens_hsa034100.45320630
133Metabolic pathways_Homo sapiens_hsa011000.45273656
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44655679
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.44141061
136mTOR signaling pathway_Homo sapiens_hsa041500.44096002
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43965339
138Basal transcription factors_Homo sapiens_hsa030220.43729348
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43587076
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39315477
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38233810
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37338195
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37192132
144Insulin signaling pathway_Homo sapiens_hsa049100.36296235
145Ether lipid metabolism_Homo sapiens_hsa005650.34145519
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33465515
147Non-small cell lung cancer_Homo sapiens_hsa052230.33339338
148Endometrial cancer_Homo sapiens_hsa052130.32271442
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23577825
150Colorectal cancer_Homo sapiens_hsa052100.23309959
151Prion diseases_Homo sapiens_hsa050200.22915375
152Alzheimers disease_Homo sapiens_hsa050100.21554644
153Tight junction_Homo sapiens_hsa045300.20831307
154Bile secretion_Homo sapiens_hsa049760.20658220

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