ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of telomere maintenance (GO:0032205)	6.55068724
2	negative regulation of telomerase activity (GO:0051974)	5.00195798
3	DNA damage induced protein phosphorylation (GO:0006975)	4.58709767
4	regulation of telomere maintenance via telomerase (GO:0032210)	4.44954183
5	snRNA processing (GO:0016180)	4.30594322
6	behavioral response to nicotine (GO:0035095)	4.12774955
7	positive regulation of protein kinase C signaling (GO:0090037)	4.08171288
8	positive regulation of triglyceride biosynthetic process (GO:0010867)	4.05199011
9	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.92582250
10	snRNA metabolic process (GO:0016073)	3.80981102
11	axoneme assembly (GO:0035082)	3.80293370
12	phosphatidylglycerol biosynthetic process (GO:0006655)	3.70317523
13	fucose catabolic process (GO:0019317)	3.67136543
14	L-fucose metabolic process (GO:0042354)	3.67136543
15	L-fucose catabolic process (GO:0042355)	3.67136543
16	protein polyglutamylation (GO:0018095)	3.48944118
17	regulation of telomere maintenance (GO:0032204)	3.48539303
18	regulation of telomerase activity (GO:0051972)	3.45118489
19	lymphangiogenesis (GO:0001946)	3.26761080
20	cell migration in hindbrain (GO:0021535)	3.25000867
21	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.23204877
22	dendritic spine morphogenesis (GO:0060997)	3.22457329
23	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.19027730
24	regulation of triglyceride biosynthetic process (GO:0010866)	3.17320575
25	interkinetic nuclear migration (GO:0022027)	3.17110522
26	histone H3-K4 trimethylation (GO:0080182)	3.11589972
27	glycerophospholipid catabolic process (GO:0046475)	3.10569845
28	nephron tubule morphogenesis (GO:0072078)	3.01646237
29	nephron epithelium morphogenesis (GO:0072088)	3.01646237
30	negative regulation of DNA biosynthetic process (GO:2000279)	3.00425552
31	auditory receptor cell stereocilium organization (GO:0060088)	2.95191471
32	positive regulation of triglyceride metabolic process (GO:0090208)	2.93219354
33	opioid receptor signaling pathway (GO:0038003)	2.92294049
34	epithelial cilium movement (GO:0003351)	2.91052403
35	cardiac right ventricle morphogenesis (GO:0003215)	2.90115606
36	arginine catabolic process (GO:0006527)	2.86089361
37	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.85957149
38	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.85340452
39	cellular response to exogenous dsRNA (GO:0071360)	2.81933471
40	drug catabolic process (GO:0042737)	2.78826781
41	positive regulation of histone deacetylation (GO:0031065)	2.78172528
42	brain morphogenesis (GO:0048854)	2.77280673
43	axon ensheathment in central nervous system (GO:0032291)	2.75775525
44	central nervous system myelination (GO:0022010)	2.75775525
45	exogenous drug catabolic process (GO:0042738)	2.73844976
46	cerebral cortex neuron differentiation (GO:0021895)	2.73723788
47	endothelial cell differentiation (GO:0045446)	2.72908399
48	positive regulation of CREB transcription factor activity (GO:0032793)	2.72644107
49	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	2.71607624
50	meiotic chromosome segregation (GO:0045132)	2.71120751
51	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.69448074
52	cellular response to pH (GO:0071467)	2.65449759
53	tryptophan catabolic process (GO:0006569)	2.64441331
54	indole-containing compound catabolic process (GO:0042436)	2.64441331
55	indolalkylamine catabolic process (GO:0046218)	2.64441331
56	heart valve formation (GO:0003188)	2.61630265
57	cellular response to ATP (GO:0071318)	2.58406148
58	transmission of nerve impulse (GO:0019226)	2.55691884
59	positive regulation of fatty acid oxidation (GO:0046321)	2.55185390
60	preassembly of GPI anchor in ER membrane (GO:0016254)	2.54134549
61	positive regulation of DNA biosynthetic process (GO:2000573)	2.50660334
62	cilium movement (GO:0003341)	2.48077923
63	detection of light stimulus involved in visual perception (GO:0050908)	2.45989373
64	detection of light stimulus involved in sensory perception (GO:0050962)	2.45989373
65	inner ear receptor stereocilium organization (GO:0060122)	2.44811640
66	gamma-aminobutyric acid transport (GO:0015812)	2.43542932
67	C-terminal protein lipidation (GO:0006501)	2.43309129
68	sulfate transmembrane transport (GO:1902358)	2.42383544
69	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.41973072
70	negative regulation of mast cell activation (GO:0033004)	2.41885305
71	negative regulation of cAMP-mediated signaling (GO:0043951)	2.41360236
72	regulation of synapse maturation (GO:0090128)	2.40552532
73	fucosylation (GO:0036065)	2.40436942
74	positive regulation of fatty acid transport (GO:2000193)	2.38691574
75	cell proliferation in forebrain (GO:0021846)	2.37412255
76	positive regulation of mitochondrial fission (GO:0090141)	2.37230603
77	peptide biosynthetic process (GO:0043043)	2.36143177
78	regulation of mitochondrial fission (GO:0090140)	2.35842470
79	mitochondrion degradation (GO:0000422)	2.35664122
80	retina development in camera-type eye (GO:0060041)	2.35271709
81	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.35074413
82	NADH dehydrogenase complex assembly (GO:0010257)	2.35074413
83	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.35074413
84	superoxide anion generation (GO:0042554)	2.34772115
85	behavioral response to ethanol (GO:0048149)	2.34759195
86	regulation of triglyceride metabolic process (GO:0090207)	2.33336135
87	basic amino acid transport (GO:0015802)	2.33246615
88	auditory behavior (GO:0031223)	2.32782757
89	fatty acid transmembrane transport (GO:1902001)	2.32058496
90	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.31130510
91	dermatan sulfate metabolic process (GO:0030205)	2.30818082
92	parturition (GO:0007567)	2.30385582
93	regulation of ruffle assembly (GO:1900027)	2.29216930
94	lysosome organization (GO:0007040)	2.28738009
95	lytic vacuole organization (GO:0080171)	2.28738009
96	base-excision repair, AP site formation (GO:0006285)	2.26610788
97	microtubule severing (GO:0051013)	2.25394642
98	regulation of synapse structural plasticity (GO:0051823)	2.25342935
99	positive regulation of defense response to virus by host (GO:0002230)	2.24712364
100	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.24651333

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.02213043
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.24794788
3	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	3.20103687
4	DROSHA_22980978_ChIP-Seq_HELA_Human	3.02740516
5	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.23595849
6	P68_20966046_ChIP-Seq_HELA_Human	2.20693819
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.15985897
8	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.12401598
9	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.08411516
10	BCL6_27268052_Chip-Seq_Bcells_Human	1.97841647
11	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.96264523
12	CTCF_27219007_Chip-Seq_Bcells_Human	1.95609065
13	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.94988350
14	ZNF274_21170338_ChIP-Seq_K562_Hela	1.94618887
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.83434182
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.80152884
17	LXR_22292898_ChIP-Seq_THP-1_Human	1.79452533
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79132358
19	ERA_21632823_ChIP-Seq_H3396_Human	1.74418647
20	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.73643921
21	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.70141050
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.69939876
23	PHF8_20622854_ChIP-Seq_HELA_Human	1.66403244
24	E2F1_20622854_ChIP-Seq_HELA_Human	1.65091641
25	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.61836275
26	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.58435881
27	BCOR_27268052_Chip-Seq_Bcells_Human	1.53964205
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.53066232
29	OCT4_19829295_ChIP-Seq_ESCs_Human	1.52308296
30	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.50992285
31	SMC4_20622854_ChIP-Seq_HELA_Human	1.49386728
32	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.48732659
33	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.48058003
34	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.40080347
35	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.38950972
36	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.35259690
37	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.35153760
38	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.34188837
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33597740
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.32467416
41	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.32242261
42	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.31844880
43	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.31678558
44	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.30759888
45	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.30044220
46	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.29718871
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29589079
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28246952
49	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.28196299
50	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.27440333
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.27030253
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26359805
53	P300_27268052_Chip-Seq_Bcells_Human	1.25784848
54	SA1_27219007_Chip-Seq_Bcells_Human	1.25555100
55	OCT4_20526341_ChIP-Seq_ESCs_Human	1.25025560
56	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.24228267
57	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.22592332
58	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.22038690
59	CTCF_20526341_ChIP-Seq_ESCs_Human	1.20856552
60	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.19904727
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19598651
62	* TP63_22573176_ChIP-Seq_HFKS_Human	1.19256259
63	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.18342464
64	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16817924
65	P53_21459846_ChIP-Seq_SAOS-2_Human	1.16259389
66	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.16143494
67	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.13196518
68	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.13060015
69	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12323268
70	VDR_22108803_ChIP-Seq_LS180_Human	1.12134391
71	RAC3_21632823_ChIP-Seq_H3396_Human	1.10608927
72	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.10377564
73	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.09890826
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.08022120
75	KDM2B_26808549_Chip-Seq_K562_Human	1.07756321
76	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.06981085
77	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.06481700
78	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.06150201
79	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06146914
80	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.05097367
81	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.04325875
82	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03606559
83	KLF4_19829295_ChIP-Seq_ESCs_Human	1.03171458
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03155116
85	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.02964984
86	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.02633891
87	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.02076727
88	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.02076727
89	CREB1_26743006_Chip-Seq_LNCaP_Human	1.01309013
90	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.00772501
91	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.00187587
92	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.00062700
93	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.99662574
94	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.99431504
95	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.98728123
96	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.95242824
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.95066873
98	TP53_22573176_ChIP-Seq_HFKS_Human	0.94631662
99	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.94605841
100	TP53_22127205_ChIP-Seq_IMR90_Human	0.94482485

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.66685926
2	MP0003880_abnormal_central_pattern	3.44306153
3	MP0004133_heterotaxia	2.81435359
4	MP0002653_abnormal_ependyma_morphology	2.58351654
5	MP0006276_abnormal_autonomic_nervous	2.39295659
6	MP0005646_abnormal_pituitary_gland	2.34460309
7	MP0005167_abnormal_blood-brain_barrier	2.24088344
8	MP0004043_abnormal_pH_regulation	2.20908325
9	MP0001968_abnormal_touch/_nociception	2.06463266
10	MP0002876_abnormal_thyroid_physiology	2.06440460
11	MP0009384_cardiac_valve_regurgitation	1.99088403
12	MP0008875_abnormal_xenobiotic_pharmacok	1.98800242
13	MP0001986_abnormal_taste_sensitivity	1.97064594
14	MP0001502_abnormal_circadian_rhythm	1.94001502
15	MP0009745_abnormal_behavioral_response	1.93597819
16	MP0002822_catalepsy	1.88257503
17	MP0005551_abnormal_eye_electrophysiolog	1.83381047
18	MP0003787_abnormal_imprinting	1.82383972
19	MP0004145_abnormal_muscle_electrophysio	1.78401670
20	MP0006292_abnormal_olfactory_placode	1.76421044
21	MP0002249_abnormal_larynx_morphology	1.75002672
22	MP0003646_muscle_fatigue	1.72688527
23	MP0002735_abnormal_chemical_nociception	1.64069647
24	MP0000013_abnormal_adipose_tissue	1.59733423
25	MP0002572_abnormal_emotion/affect_behav	1.52024966
26	MP0002733_abnormal_thermal_nociception	1.51913383
27	MP0004270_analgesia	1.51623436
28	MP0001970_abnormal_pain_threshold	1.51494405
29	MP0003635_abnormal_synaptic_transmissio	1.50382655
30	MP0005645_abnormal_hypothalamus_physiol	1.49779010
31	MP0002837_dystrophic_cardiac_calcinosis	1.48208809
32	MP0002063_abnormal_learning/memory/cond	1.47725375
33	MP0008872_abnormal_physiological_respon	1.45817592
34	MP0005595_abnormal_vascular_smooth	1.45694046
35	MP0004147_increased_porphyrin_level	1.42783479
36	MP0008775_abnormal_heart_ventricle	1.42274379
37	MP0003172_abnormal_lysosome_physiology	1.41440258
38	MP0004381_abnormal_hair_follicle	1.41384039
39	MP0002064_seizures	1.40808177
40	MP0002557_abnormal_social/conspecific_i	1.39226780
41	MP0003879_abnormal_hair_cell	1.38960352
42	MP0002138_abnormal_hepatobiliary_system	1.37755459
43	MP0000631_abnormal_neuroendocrine_gland	1.32770339
44	MP0000778_abnormal_nervous_system	1.32479608
45	MP0002272_abnormal_nervous_system	1.32261767
46	MP0000015_abnormal_ear_pigmentation	1.32038155
47	MP0002234_abnormal_pharynx_morphology	1.29907082
48	MP0002127_abnormal_cardiovascular_syste	1.29839802
49	MP0000026_abnormal_inner_ear	1.28795825
50	MP0004859_abnormal_synaptic_plasticity	1.25553664
51	MP0003011_delayed_dark_adaptation	1.25347522
52	MP0003195_calcinosis	1.23530561
53	MP0005174_abnormal_tail_pigmentation	1.21922047
54	MP0000230_abnormal_systemic_arterial	1.20440157
55	MP0004885_abnormal_endolymph	1.20346291
56	MP0003137_abnormal_impulse_conducting	1.19149339
57	MP0002928_abnormal_bile_duct	1.18983945
58	MP0005670_abnormal_white_adipose	1.18679607
59	MP0002102_abnormal_ear_morphology	1.17925760
60	MP0005360_urolithiasis	1.14502725
61	MP0003938_abnormal_ear_development	1.11745308
62	MP0001501_abnormal_sleep_pattern	1.10352722
63	MP0000383_abnormal_hair_follicle	1.10285624
64	MP0005075_abnormal_melanosome_morpholog	1.09118906
65	MP0004130_abnormal_muscle_cell	1.07721778
66	MP0002933_joint_inflammation	1.07149319
67	MP0006072_abnormal_retinal_apoptosis	1.05804152
68	MP0002734_abnormal_mechanical_nocicepti	1.05560170
69	MP0001764_abnormal_homeostasis	1.05345188
70	MP0000427_abnormal_hair_cycle	1.05320509
71	MP0002163_abnormal_gland_morphology	1.04436883
72	MP0002932_abnormal_joint_morphology	1.03891539
73	MP0005448_abnormal_energy_balance	1.02675948
74	MP0004742_abnormal_vestibular_system	1.00864941
75	MP0000566_synostosis	0.99990861
76	MP0001486_abnormal_startle_reflex	0.98048544
77	MP0005195_abnormal_posterior_eye	0.97728374
78	MP0008995_early_reproductive_senescence	0.95314975
79	MP0002752_abnormal_somatic_nervous	0.93172514
80	MP0001963_abnormal_hearing_physiology	0.92420582
81	MP0002638_abnormal_pupillary_reflex	0.90929178
82	MP0005423_abnormal_somatic_nervous	0.88011701
83	MP0003878_abnormal_ear_physiology	0.86222562
84	MP0005377_hearing/vestibular/ear_phenot	0.86222562
85	MP0002882_abnormal_neuron_morphology	0.85609701
86	MP0001485_abnormal_pinna_reflex	0.84535391
87	MP0000003_abnormal_adipose_tissue	0.83871517
88	MP0009046_muscle_twitch	0.82074216
89	MP0008789_abnormal_olfactory_epithelium	0.80416921
90	MP0010329_abnormal_lipoprotein_level	0.80087674
91	MP0004142_abnormal_muscle_tone	0.76953148
92	MP0005253_abnormal_eye_physiology	0.76077672
93	MP0000681_abnormal_thyroid_gland	0.76072156
94	MP0005386_behavior/neurological_phenoty	0.75756006
95	MP0004924_abnormal_behavior	0.75756006
96	MP0002736_abnormal_nociception_after	0.75249878
97	MP0002184_abnormal_innervation	0.75245235
98	MP0001324_abnormal_eye_pigmentation	0.74043086
99	MP0000678_abnormal_parathyroid_gland	0.73659491
100	MP0005058_abnormal_lysosome_morphology	0.73142576

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.33433159
2	Molar tooth sign on MRI (HP:0002419)	4.33433159
3	Abnormality of the aortic arch (HP:0012303)	3.90937731
4	Chronic hepatic failure (HP:0100626)	3.83307421
5	Nephronophthisis (HP:0000090)	3.76174311
6	Pancreatic cysts (HP:0001737)	3.70069137
7	Cystic liver disease (HP:0006706)	3.61613915
8	Pancreatic fibrosis (HP:0100732)	3.57089030
9	Congenital stationary night blindness (HP:0007642)	3.43612073
10	J-shaped sella turcica (HP:0002680)	3.40687264
11	Delayed CNS myelination (HP:0002188)	3.39618841
12	True hermaphroditism (HP:0010459)	3.37185846
13	Bile duct proliferation (HP:0001408)	3.20327856
14	Abnormal biliary tract physiology (HP:0012439)	3.20327856
15	Abnormality of the renal medulla (HP:0100957)	3.19159580
16	Type II lissencephaly (HP:0007260)	3.19025624
17	Abnormal rod and cone electroretinograms (HP:0008323)	3.14279004
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.11793142
19	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.09020258
20	Decreased circulating renin level (HP:0003351)	3.04080455
21	Occipital encephalocele (HP:0002085)	3.03316106
22	Lymphangioma (HP:0100764)	2.99259222
23	Hyperventilation (HP:0002883)	2.95960752
24	Esophageal atresia (HP:0002032)	2.77021372
25	Tubular atrophy (HP:0000092)	2.75524346
26	Abnormal drinking behavior (HP:0030082)	2.73922622
27	Polydipsia (HP:0001959)	2.73922622
28	Inability to walk (HP:0002540)	2.70556661
29	Adactyly (HP:0009776)	2.70370275
30	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.60423081
31	Congenital hepatic fibrosis (HP:0002612)	2.56056304
32	Sleep apnea (HP:0010535)	2.50488076
33	Clumsiness (HP:0002312)	2.46709882
34	Retinal dysplasia (HP:0007973)	2.44949076
35	Rectal prolapse (HP:0002035)	2.44170232
36	Prolonged QT interval (HP:0001657)	2.44163112
37	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.42315502
38	Decreased central vision (HP:0007663)	2.38833469
39	Obstructive sleep apnea (HP:0002870)	2.37583556
40	Concave nail (HP:0001598)	2.32777917
41	Attenuation of retinal blood vessels (HP:0007843)	2.29063525
42	Pendular nystagmus (HP:0012043)	2.22557188
43	Pigmentary retinal degeneration (HP:0001146)	2.19387638
44	Hypoplastic ischia (HP:0003175)	2.15147991
45	Tachypnea (HP:0002789)	2.12834758
46	Gastrointestinal atresia (HP:0002589)	2.11110491
47	Aplasia/Hypoplasia of the patella (HP:0006498)	2.10781977
48	Stridor (HP:0010307)	2.10476974
49	Intellectual disability, severe (HP:0010864)	2.10159024
50	Genetic anticipation (HP:0003743)	2.10129050
51	Abnormality of the renal cortex (HP:0011035)	2.08579031
52	Abolished electroretinogram (ERG) (HP:0000550)	2.07846517
53	Postaxial foot polydactyly (HP:0001830)	2.05247019
54	Cerebellar dysplasia (HP:0007033)	2.05198090
55	Absent speech (HP:0001344)	2.04284449
56	Hyperkalemia (HP:0002153)	2.03090776
57	Medial flaring of the eyebrow (HP:0010747)	2.00907781
58	Renal dysplasia (HP:0000110)	2.00907162
59	Severe muscular hypotonia (HP:0006829)	1.99516239
60	Polyuria (HP:0000103)	1.98561180
61	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96648623
62	Absent/shortened dynein arms (HP:0200106)	1.96648623
63	Increased cerebral lipofuscin (HP:0011813)	1.93881538
64	Optic nerve coloboma (HP:0000588)	1.92312423
65	Humeroradial synostosis (HP:0003041)	1.91518047
66	Synostosis involving the elbow (HP:0003938)	1.91518047
67	Anencephaly (HP:0002323)	1.90891995
68	Cerebral palsy (HP:0100021)	1.90052610
69	Vitreoretinal degeneration (HP:0000655)	1.89608646
70	Gait imbalance (HP:0002141)	1.88906204
71	Stage 5 chronic kidney disease (HP:0003774)	1.88409050
72	Severe Myopia (HP:0011003)	1.86528717
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.84614277
74	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.84217790
75	Increased corneal curvature (HP:0100692)	1.83508085
76	Keratoconus (HP:0000563)	1.83508085
77	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.83056154
78	Patellar aplasia (HP:0006443)	1.82125558
79	Aplasia/hypoplasia of the femur (HP:0005613)	1.81847420
80	Broad-based gait (HP:0002136)	1.81782927
81	Mesangial abnormality (HP:0001966)	1.79542078
82	Progressive cerebellar ataxia (HP:0002073)	1.78848116
83	Retinitis pigmentosa (HP:0000510)	1.77303091
84	Abnormality of the femoral head (HP:0003368)	1.76076015
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.74811927
86	Abnormality of renin-angiotensin system (HP:0000847)	1.73864068
87	Joint stiffness (HP:0001387)	1.73266062
88	Rib fusion (HP:0000902)	1.70924033
89	Spinal canal stenosis (HP:0003416)	1.69609677
90	Sclerocornea (HP:0000647)	1.69136502
91	Focal seizures (HP:0007359)	1.68747323
92	Thyroid-stimulating hormone excess (HP:0002925)	1.68177890
93	Lissencephaly (HP:0001339)	1.67005787
94	Severe visual impairment (HP:0001141)	1.66477254
95	Abnormal urine output (HP:0012590)	1.66376989
96	Retinal atrophy (HP:0001105)	1.65015574
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.64435135
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.64435135
99	Protruding tongue (HP:0010808)	1.64171231
100	Progressive microcephaly (HP:0000253)	1.63191789

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK2	5.12340285
2	MAP2K6	4.81644640
3	TLK1	4.13342583
4	SIK2	3.10851021
5	MAP4K2	3.06055951
6	FRK	3.00471703
7	WNK4	2.73935011
8	MAPK15	2.52026462
9	NME1	2.26910825
10	TNK2	2.14907852
11	ADRBK2	1.80293023
12	SIK1	1.73893598
13	MAPKAPK3	1.73077160
14	MUSK	1.72231225
15	MAP3K7	1.69424386
16	TIE1	1.67821891
17	DAPK2	1.66806466
18	BLK	1.56569465
19	NTRK3	1.48324201
20	GRK1	1.35586808
21	PINK1	1.28763397
22	KDR	1.28076056
23	CASK	1.27223852
24	MAP3K5	1.24684416
25	MARK1	1.23569163
26	TAOK3	1.21137829
27	TRIB3	1.19156527
28	MAPK13	1.16777794
29	INSRR	1.16724262
30	MARK2	1.15704565
31	RIPK1	1.04861059
32	HIPK2	1.04565514
33	CAMK1	0.98447024
34	PRKD2	0.95933843
35	EPHA4	0.94271913
36	NTRK2	0.91246335
37	RPS6KA6	0.91129706
38	CDK19	0.89365944
39	RPS6KA2	0.89057008
40	OXSR1	0.88943842
41	ERBB2	0.88188610
42	CAMKK1	0.86297060
43	PTK2B	0.85451812
44	DYRK2	0.79416887
45	MAP3K4	0.78345480
46	PKN1	0.75622248
47	PRKD3	0.73781142
48	MAP3K6	0.73675357
49	CAMK4	0.73033051
50	BMX	0.69972279
51	PDPK1	0.67276012
52	RPS6KC1	0.66832986
53	RPS6KL1	0.66832986
54	PRKAA1	0.66712422
55	PIK3CA	0.66548546
56	ADRBK1	0.66368014
57	CAMKK2	0.64008760
58	STK11	0.63941418
59	KIT	0.62286558
60	MAP2K4	0.61789125
61	DYRK1B	0.59841922
62	PDK1	0.58249903
63	BCKDK	0.57874845
64	PHKG1	0.57782039
65	PHKG2	0.57782039
66	IKBKB	0.56656336
67	TBK1	0.56187287
68	EPHB2	0.55984337
69	EPHA3	0.55119457
70	PRKAA2	0.54315579
71	PRKCI	0.53738118
72	PRKCZ	0.52708863
73	CHUK	0.51679558
74	MAP3K11	0.49101982
75	PRKD1	0.47215132
76	STK39	0.46348005
77	EPHA2	0.46040704
78	FGFR2	0.45195169
79	MAP4K1	0.44842333
80	MAPK7	0.44780410
81	TXK	0.43899675
82	MAP2K2	0.43414681
83	IKBKE	0.42821381
84	PTK6	0.41522959
85	CAMK1D	0.41302049
86	BMPR1B	0.40182011
87	MAPK12	0.39504174
88	WNK3	0.39124607
89	CSF1R	0.38700723
90	FER	0.38562344
91	MAP2K7	0.38130697
92	PRKCG	0.37418546
93	MARK3	0.36830754
94	MAPKAPK5	0.36684625
95	EPHB1	0.35492684
96	EEF2K	0.34756838
97	PKN2	0.34638209
98	PRKCQ	0.31822629
99	PRKCH	0.31531768
100	MAPK8	0.30281116

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.27446761
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.94914486
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.92401343
4	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.54062051
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39361428
6	Regulation of autophagy_Homo sapiens_hsa04140	2.26787697
7	Phototransduction_Homo sapiens_hsa04744	2.24816321
8	Sulfur relay system_Homo sapiens_hsa04122	2.08839196
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97090453
10	Ether lipid metabolism_Homo sapiens_hsa00565	1.96275273
11	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.94067729
12	Notch signaling pathway_Homo sapiens_hsa04330	1.86880730
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81629378
14	ABC transporters_Homo sapiens_hsa02010	1.77803529
15	Nicotine addiction_Homo sapiens_hsa05033	1.59461855
16	Morphine addiction_Homo sapiens_hsa05032	1.57432767
17	Butanoate metabolism_Homo sapiens_hsa00650	1.55191308
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.53073926
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.48310457
20	Other glycan degradation_Homo sapiens_hsa00511	1.47380990
21	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.44721655
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.44054332
23	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.42687302
24	Caffeine metabolism_Homo sapiens_hsa00232	1.41094141
25	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.40832233
26	Insulin secretion_Homo sapiens_hsa04911	1.38607848
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38204296
28	Circadian entrainment_Homo sapiens_hsa04713	1.33957513
29	Histidine metabolism_Homo sapiens_hsa00340	1.33800789
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.28616042
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26126659
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.21306497
33	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.21147822
34	Cocaine addiction_Homo sapiens_hsa05030	1.18942917
35	Taste transduction_Homo sapiens_hsa04742	1.15850643
36	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.10573988
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.10251320
38	GABAergic synapse_Homo sapiens_hsa04727	1.10143022
39	Peroxisome_Homo sapiens_hsa04146	1.08833399
40	Asthma_Homo sapiens_hsa05310	1.08819571
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.08599784
42	Salivary secretion_Homo sapiens_hsa04970	1.08108920
43	GnRH signaling pathway_Homo sapiens_hsa04912	1.07446173
44	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.01351093
45	Axon guidance_Homo sapiens_hsa04360	1.01013913
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97103440
47	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.94582416
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93364061
49	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.92795683
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.90267234
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90113393
52	Olfactory transduction_Homo sapiens_hsa04740	0.86571760
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.86130139
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84797983
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84052615
56	Lysine degradation_Homo sapiens_hsa00310	0.81353659
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79654222
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78689946
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.78001599
60	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.75012816
61	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.67475070
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67025183
63	Serotonergic synapse_Homo sapiens_hsa04726	0.66597383
64	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.66482227
65	Cholinergic synapse_Homo sapiens_hsa04725	0.65199313
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.63667388
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.63030199
68	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.62381806
69	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.60164953
70	Retinol metabolism_Homo sapiens_hsa00830	0.59691968
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59062555
72	MAPK signaling pathway_Homo sapiens_hsa04010	0.58081869
73	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.57871234
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54498546
75	Choline metabolism in cancer_Homo sapiens_hsa05231	0.54209267
76	Lysosome_Homo sapiens_hsa04142	0.52929960
77	AMPK signaling pathway_Homo sapiens_hsa04152	0.52054549
78	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.52035278
79	Fanconi anemia pathway_Homo sapiens_hsa03460	0.49389335
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.49380673
81	Oxidative phosphorylation_Homo sapiens_hsa00190	0.49324890
82	Bile secretion_Homo sapiens_hsa04976	0.48764789
83	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.47770312
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.47250694
85	Gastric acid secretion_Homo sapiens_hsa04971	0.46942498
86	Ras signaling pathway_Homo sapiens_hsa04014	0.44969711
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44932251
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43176407
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42234946
90	Fatty acid degradation_Homo sapiens_hsa00071	0.42076384
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.41533187
92	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.40613483
93	Renin secretion_Homo sapiens_hsa04924	0.40066230
94	Glucagon signaling pathway_Homo sapiens_hsa04922	0.39061262
95	Long-term depression_Homo sapiens_hsa04730	0.38676457
96	VEGF signaling pathway_Homo sapiens_hsa04370	0.37778742
97	Circadian rhythm_Homo sapiens_hsa04710	0.37663491
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.34965881
99	Metabolic pathways_Homo sapiens_hsa01100	0.34150709
100	Insulin resistance_Homo sapiens_hsa04931	0.33569927

EXD3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »