EXO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)5.20488918
2DNA strand elongation involved in DNA replication (GO:0006271)5.15845439
3DNA unwinding involved in DNA replication (GO:0006268)4.98604379
4DNA strand elongation (GO:0022616)4.91366087
5DNA replication checkpoint (GO:0000076)4.88622764
6protein localization to kinetochore (GO:0034501)4.85594527
7telomere maintenance via semi-conservative replication (GO:0032201)4.80799494
8mitotic metaphase plate congression (GO:0007080)4.71989205
9telomere maintenance via recombination (GO:0000722)4.44901503
10chromatin remodeling at centromere (GO:0031055)4.41229257
11CENP-A containing nucleosome assembly (GO:0034080)4.39006500
12mitotic recombination (GO:0006312)4.38011610
13nuclear pore organization (GO:0006999)4.35205019
14DNA replication-dependent nucleosome assembly (GO:0006335)4.29079838
15DNA replication-dependent nucleosome organization (GO:0034723)4.29079838
16kinetochore organization (GO:0051383)4.28765400
17metaphase plate congression (GO:0051310)4.21591649
18nucleobase biosynthetic process (GO:0046112)4.18216648
19nuclear pore complex assembly (GO:0051292)4.16646817
20mitotic chromosome condensation (GO:0007076)4.12476113
21protein localization to chromosome, centromeric region (GO:0071459)4.12286450
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.04141158
23mitotic nuclear envelope disassembly (GO:0007077)4.02744219
24DNA replication-independent nucleosome assembly (GO:0006336)4.01983109
25DNA replication-independent nucleosome organization (GO:0034724)4.01983109
26telomere maintenance via telomere lengthening (GO:0010833)3.97833646
27attachment of spindle microtubules to kinetochore (GO:0008608)3.91911604
28establishment of integrated proviral latency (GO:0075713)3.91575949
29DNA topological change (GO:0006265)3.86901009
30IMP biosynthetic process (GO:0006188)3.86638471
31meiotic chromosome segregation (GO:0045132)3.85545116
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.85303835
33purine nucleobase biosynthetic process (GO:0009113)3.85227668
34mitotic sister chromatid segregation (GO:0000070)3.81146657
35kinetochore assembly (GO:0051382)3.78748023
36establishment of chromosome localization (GO:0051303)3.77329524
37chromosome condensation (GO:0030261)3.75618266
38nuclear envelope disassembly (GO:0051081)3.71842170
39membrane disassembly (GO:0030397)3.71842170
40histone exchange (GO:0043486)3.71495042
41non-recombinational repair (GO:0000726)3.63925293
42double-strand break repair via nonhomologous end joining (GO:0006303)3.63925293
43protein K6-linked ubiquitination (GO:0085020)3.62219565
44regulation of DNA endoreduplication (GO:0032875)3.60655371
45DNA synthesis involved in DNA repair (GO:0000731)3.60552854
46sister chromatid segregation (GO:0000819)3.57607757
47regulation of translational fidelity (GO:0006450)3.57435415
48folic acid-containing compound biosynthetic process (GO:0009396)3.57327466
49regulation of spindle organization (GO:0090224)3.56955196
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.52102221
51DNA ligation (GO:0006266)3.51765447
52DNA geometric change (GO:0032392)3.51205290
53DNA duplex unwinding (GO:0032508)3.50614331
54regulation of nuclear cell cycle DNA replication (GO:0033262)3.50204208
55spindle checkpoint (GO:0031577)3.49648599
56heterochromatin organization (GO:0070828)3.48970280
57maturation of SSU-rRNA (GO:0030490)3.44980990
58mitotic sister chromatid cohesion (GO:0007064)3.43251272
59DNA packaging (GO:0006323)3.42514513
60negative regulation of chromosome segregation (GO:0051985)3.41436202
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.38907368
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.38907368
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.38907368
64negative regulation of sister chromatid segregation (GO:0033046)3.38907368
65spindle assembly checkpoint (GO:0071173)3.37193024
66IMP metabolic process (GO:0046040)3.36746131
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36282683
68ribosome assembly (GO:0042255)3.35215573
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33443934
70regulation of chromosome segregation (GO:0051983)3.32680740
71formation of translation preinitiation complex (GO:0001731)3.32665013
72maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.32624532
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32506459
74chromatin assembly or disassembly (GO:0006333)3.31860514
75positive regulation of chromosome segregation (GO:0051984)3.31155390
76mitotic spindle assembly checkpoint (GO:0007094)3.30214721
77regulation of centrosome cycle (GO:0046605)3.29106137
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28621946
79mitotic spindle checkpoint (GO:0071174)3.26821498
80pore complex assembly (GO:0046931)3.26237405
81ribosome biogenesis (GO:0042254)3.25374899
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25038638
83telomere maintenance (GO:0000723)3.24753246
84telomere organization (GO:0032200)3.23220207
85protein localization to chromosome (GO:0034502)3.21103428
86* mismatch repair (GO:0006298)3.16915508
87chromosome segregation (GO:0007059)3.16679635
88regulation of sister chromatid segregation (GO:0033045)3.15767258
89regulation of mitotic sister chromatid separation (GO:0010965)3.15767258
90regulation of mitotic sister chromatid segregation (GO:0033047)3.15767258
91transcription-coupled nucleotide-excision repair (GO:0006283)3.15070731
92regulation of centrosome duplication (GO:0010824)3.14454508
93ribosomal small subunit assembly (GO:0000028)3.13846428
94DNA strand renaturation (GO:0000733)3.13571103
95regulation of helicase activity (GO:0051095)3.12303642
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12244208
97regulation of centriole replication (GO:0046599)3.09764792
98nuclear envelope organization (GO:0006998)3.09699924
99ATP-dependent chromatin remodeling (GO:0043044)3.09220113
100DNA conformation change (GO:0071103)3.07811097
101regulation of mitotic spindle organization (GO:0060236)3.07324372
102protein complex localization (GO:0031503)3.05292664
103regulation of histone H3-K9 methylation (GO:0051570)3.03914471
104DNA deamination (GO:0045006)3.03221095
105intra-S DNA damage checkpoint (GO:0031573)3.00576604
106mitotic G2/M transition checkpoint (GO:0044818)3.00190972
107spliceosomal snRNP assembly (GO:0000387)2.99706121
108DNA replication (GO:0006260)2.98901120
109replication fork processing (GO:0031297)2.97791956
110regulation of sister chromatid cohesion (GO:0007063)2.95805001
111translesion synthesis (GO:0019985)2.95036488
112mitotic cell cycle (GO:0000278)2.94353004
113base-excision repair (GO:0006284)2.94171424
114ribonucleoprotein complex biogenesis (GO:0022613)2.93871247
115maturation of 5.8S rRNA (GO:0000460)2.92300600
116rRNA processing (GO:0006364)2.91373255
117postreplication repair (GO:0006301)2.91190233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.85539387
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42988489
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.13294277
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64194320
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05320567
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01192960
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89832543
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80311391
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.66189328
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61043292
11AR_21909140_ChIP-Seq_LNCAP_Human2.50498163
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43324665
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.41002289
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39547949
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.38014535
16* E2F1_21310950_ChIP-Seq_MCF-7_Human2.37994048
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35649152
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30258336
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24698173
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21158951
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19686555
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18147444
23* XRN2_22483619_ChIP-Seq_HELA_Human2.10966336
24VDR_23849224_ChIP-Seq_CD4+_Human2.04550092
25E2F7_22180533_ChIP-Seq_HELA_Human11.0353194
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96135968
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95667893
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.89641838
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86449128
30FOXP3_21729870_ChIP-Seq_TREG_Human1.84667507
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83690599
32DCP1A_22483619_ChIP-Seq_HELA_Human1.81101277
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79214785
34TTF2_22483619_ChIP-Seq_HELA_Human1.75900386
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75839368
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67755342
37* GABP_19822575_ChIP-Seq_HepG2_Human1.64347290
38* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61763601
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60475665
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60453499
41ELK1_19687146_ChIP-ChIP_HELA_Human1.59759422
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59603454
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59457652
44CIITA_25753668_ChIP-Seq_RAJI_Human1.55765517
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.55003609
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50900911
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45752137
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42618851
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42134489
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42070457
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.40583732
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39679708
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38540373
54KDM5A_27292631_Chip-Seq_BREAST_Human1.36057048
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35614260
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35282651
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.33508951
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32514754
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28155252
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27287556
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21299635
62MYC_22102868_ChIP-Seq_BL_Human1.21261986
63* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19331887
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19138609
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18182690
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.17401709
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13764893
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13302372
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12858499
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12593136
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11582399
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11291881
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10100416
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09856101
75MYC_18940864_ChIP-ChIP_HL60_Human1.07034104
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.02766697
77TFEB_21752829_ChIP-Seq_HELA_Human1.00753145
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00389118
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99260334
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97918019
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94809963
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91513653
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91280838
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.90241717
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.89449717
86TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86956285
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86842009
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85448784
89CHD1_26751641_Chip-Seq_LNCaP_Human0.85415699
90ZNF263_19887448_ChIP-Seq_K562_Human0.83570362
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83408153
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82582969
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82582969
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82582969
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81899398
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81703875
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80169780
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79697977
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77690947
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77354660
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77170695
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76811088
103TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76648772
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76327983
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.76237305
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75943683
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75877612
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.75520797
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74915117
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71139064
111* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70665601
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63793483
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.63220971
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.59311664
115IRF1_19129219_ChIP-ChIP_H3396_Human0.58802712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.33609289
2* MP0010094_abnormal_chromosome_stability5.06213770
3MP0003111_abnormal_nucleus_morphology4.72023533
4MP0008057_abnormal_DNA_replication4.53641417
5MP0004957_abnormal_blastocyst_morpholog4.25150879
6MP0003077_abnormal_cell_cycle4.10780793
7* MP0008058_abnormal_DNA_repair3.43299482
8MP0003123_paternal_imprinting3.00283848
9MP0008007_abnormal_cellular_replicative2.79283839
10MP0008932_abnormal_embryonic_tissue2.76744106
11MP0008877_abnormal_DNA_methylation2.70640165
12MP0001730_embryonic_growth_arrest2.25202591
13MP0000350_abnormal_cell_proliferation2.22755983
14MP0002396_abnormal_hematopoietic_system2.18535779
15MP0003786_premature_aging2.14042209
16MP0010307_abnormal_tumor_latency2.02043500
17MP0003121_genomic_imprinting1.93872877
18MP0010352_gastrointestinal_tract_polyps1.89255571
19MP0005380_embryogenesis_phenotype1.84902055
20MP0001672_abnormal_embryogenesis/_devel1.84902055
21MP0003718_maternal_effect1.80679887
22MP0001697_abnormal_embryo_size1.73898503
23MP0000490_abnormal_crypts_of1.66521277
24MP0002085_abnormal_embryonic_tissue1.64030285
25MP0003984_embryonic_growth_retardation1.61524686
26MP0002877_abnormal_melanocyte_morpholog1.61390264
27MP0002088_abnormal_embryonic_growth/wei1.58429630
28MP0006292_abnormal_olfactory_placode1.56589759
29* MP0002210_abnormal_sex_determination1.51261766
30MP0003890_abnormal_embryonic-extraembry1.50540032
31MP0002084_abnormal_developmental_patter1.50180187
32MP0002080_prenatal_lethality1.50178986
33MP0002009_preneoplasia1.41613513
34MP0004197_abnormal_fetal_growth/weight/1.41051113
35MP0002086_abnormal_extraembryonic_tissu1.39695430
36MP0010030_abnormal_orbit_morphology1.39457553
37MP0000313_abnormal_cell_death1.39314526
38MP0004808_abnormal_hematopoietic_stem1.38929490
39MP0003315_abnormal_perineum_morphology1.34542720
40MP0003567_abnormal_fetal_cardiomyocyte1.34177433
41MP0003941_abnormal_skin_development1.33564747
42MP0001293_anophthalmia1.31787860
43* MP0002019_abnormal_tumor_incidence1.31010597
44* MP0001145_abnormal_male_reproductive1.28219791
45MP0004233_abnormal_muscle_weight1.24038631
46* MP0001929_abnormal_gametogenesis1.18101037
47MP0005076_abnormal_cell_differentiation1.17334808
48* MP0000653_abnormal_sex_gland1.16710275
49MP0002160_abnormal_reproductive_system1.12463709
50MP0006035_abnormal_mitochondrial_morpho1.12051427
51MP0003937_abnormal_limbs/digits/tail_de1.10256730
52MP0003119_abnormal_digestive_system1.10195020
53* MP0001119_abnormal_female_reproductive1.09980119
54MP0001346_abnormal_lacrimal_gland1.09669640
55MP0001661_extended_life_span1.09151955
56MP0004185_abnormal_adipocyte_glucose1.01112376
57MP0004147_increased_porphyrin_level0.97156286
58MP0005389_reproductive_system_phenotype0.92071236
59MP0000703_abnormal_thymus_morphology0.91528572
60MP0003787_abnormal_imprinting0.89097399
61MP0002111_abnormal_tail_morphology0.88862412
62MP0009333_abnormal_splenocyte_physiolog0.88845147
63MP0009053_abnormal_anal_canal0.88279467
64MP0005397_hematopoietic_system_phenotyp0.87069702
65MP0001545_abnormal_hematopoietic_system0.87069702
66MP0009672_abnormal_birth_weight0.86694426
67MP0000537_abnormal_urethra_morphology0.85972629
68MP0006054_spinal_hemorrhage0.85919725
69MP0000372_irregular_coat_pigmentation0.85696028
70MP0001915_intracranial_hemorrhage0.81309350
71MP0003763_abnormal_thymus_physiology0.81170130
72MP0003705_abnormal_hypodermis_morpholog0.80484517
73MP0002938_white_spotting0.80218063
74MP0002653_abnormal_ependyma_morphology0.79750099
75MP0002102_abnormal_ear_morphology0.79476313
76MP0001286_abnormal_eye_development0.78293177
77MP0009703_decreased_birth_body0.77166173
78MP0000566_synostosis0.76747528
79MP0005384_cellular_phenotype0.76523921
80MP0002398_abnormal_bone_marrow0.73404540
81MP0006036_abnormal_mitochondrial_physio0.72799683
82MP0002722_abnormal_immune_system0.72427380
83MP0005501_abnormal_skin_physiology0.72235986
84MP0005408_hypopigmentation0.71921073
85MP0005621_abnormal_cell_physiology0.70282585
86MP0003943_abnormal_hepatobiliary_system0.70185714
87MP0009697_abnormal_copulation0.69587232
88MP0004133_heterotaxia0.69178493
89MP0000689_abnormal_spleen_morphology0.68798461
90MP0000432_abnormal_head_morphology0.68593987
91MP0003806_abnormal_nucleotide_metabolis0.68424446
92MP0003186_abnormal_redox_activity0.66965663
93MP0002075_abnormal_coat/hair_pigmentati0.66768005
94MP0001727_abnormal_embryo_implantation0.65936931
95MP0002092_abnormal_eye_morphology0.65494083
96MP0002095_abnormal_skin_pigmentation0.65334048
97MP0005187_abnormal_penis_morphology0.65299379
98MP0000428_abnormal_craniofacial_morphol0.64104140
99* MP0003699_abnormal_female_reproductive0.63963003
100MP0000049_abnormal_middle_ear0.62657971
101MP0002234_abnormal_pharynx_morphology0.61892063
102MP0003221_abnormal_cardiomyocyte_apopto0.61860902
103MP0000358_abnormal_cell_content/0.61307565
104MP0001919_abnormal_reproductive_system0.61197520
105MP0003950_abnormal_plasma_membrane0.61082339
106MP0003656_abnormal_erythrocyte_physiolo0.60328298
107MP0008995_early_reproductive_senescence0.60150824
108* MP0003698_abnormal_male_reproductive0.58856772
109MP0003936_abnormal_reproductive_system0.58849679
110MP0000858_altered_metastatic_potential0.58585399
111MP0003755_abnormal_palate_morphology0.58493249
112MP0003935_abnormal_craniofacial_develop0.58275308
113MP0003136_yellow_coat_color0.58036745
114MP0002132_abnormal_respiratory_system0.57485013
115MP0005623_abnormal_meninges_morphology0.56977156
116MP0001186_pigmentation_phenotype0.56798233
117MP0008789_abnormal_olfactory_epithelium0.55791971
118MP0000477_abnormal_intestine_morphology0.55647634
119MP0010234_abnormal_vibrissa_follicle0.55545048
120MP0005171_absent_coat_pigmentation0.55288671
121MP0000647_abnormal_sebaceous_gland0.55227512
122MP0002429_abnormal_blood_cell0.54909157
123* MP0002161_abnormal_fertility/fecundity0.54436067
124MP0002697_abnormal_eye_size0.53625324
125MP0002233_abnormal_nose_morphology0.53353090
126MP0003385_abnormal_body_wall0.53048458
127MP0003861_abnormal_nervous_system0.52827151
128MP0005083_abnormal_biliary_tract0.52426462
129MP0002114_abnormal_axial_skeleton0.49630402
130MP0008770_decreased_survivor_rate0.48945239

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.52915934
2Chromsome breakage (HP:0040012)5.31583360
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.19570343
4Breast hypoplasia (HP:0003187)4.06964101
5Abnormality of chromosome stability (HP:0003220)3.86528693
6Meckel diverticulum (HP:0002245)3.80477518
7Patellar aplasia (HP:0006443)3.70463366
8Reticulocytopenia (HP:0001896)3.68742207
9Medulloblastoma (HP:0002885)3.64910018
10Abnormality of the preputium (HP:0100587)3.61917249
11Abnormality of the ileum (HP:0001549)3.60761152
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.47730449
13Aplasia/Hypoplasia of the patella (HP:0006498)3.45086956
14Colon cancer (HP:0003003)3.37717236
15Impulsivity (HP:0100710)3.29074772
16Selective tooth agenesis (HP:0001592)3.28059771
17Ectopic kidney (HP:0000086)3.11628221
18Abnormality of the labia minora (HP:0012880)3.10634820
19Small intestinal stenosis (HP:0012848)3.03546496
20Duodenal stenosis (HP:0100867)3.03546496
21Absent radius (HP:0003974)3.03089747
22Ependymoma (HP:0002888)2.98866162
23Oral leukoplakia (HP:0002745)2.97066916
24Absent thumb (HP:0009777)2.88121692
25Absent forearm bone (HP:0003953)2.85240967
26Aplasia involving forearm bones (HP:0009822)2.85240967
27Myelodysplasia (HP:0002863)2.83927974
28Agnosia (HP:0010524)2.81151989
29Duplicated collecting system (HP:0000081)2.78175562
30Abnormal lung lobation (HP:0002101)2.76759163
31Supernumerary spleens (HP:0009799)2.76643643
32Cortical dysplasia (HP:0002539)2.74969985
33Rhabdomyosarcoma (HP:0002859)2.73620102
34Carpal bone hypoplasia (HP:0001498)2.69264334
35Abnormality of cochlea (HP:0000375)2.66619334
36Microvesicular hepatic steatosis (HP:0001414)2.59225667
37Sloping forehead (HP:0000340)2.58281185
38Abnormal number of incisors (HP:0011064)2.57771541
39Nephroblastoma (Wilms tumor) (HP:0002667)2.56916863
40Bone marrow hypocellularity (HP:0005528)2.54255536
41Abnormality of the carotid arteries (HP:0005344)2.50752824
42Abnormality of the duodenum (HP:0002246)2.48800751
43Aplastic anemia (HP:0001915)2.46992592
44Abnormality of the renal collecting system (HP:0004742)2.46825637
45Degeneration of anterior horn cells (HP:0002398)2.44980975
46Abnormality of the anterior horn cell (HP:0006802)2.44980975
47Abnormality of cells of the erythroid lineage (HP:0012130)2.44118758
48Abnormal number of erythroid precursors (HP:0012131)2.42379264
49Embryonal renal neoplasm (HP:0011794)2.39548193
50Short thumb (HP:0009778)2.39028876
5111 pairs of ribs (HP:0000878)2.37378439
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.35168612
53Increased nuchal translucency (HP:0010880)2.31787581
54Clubbing of toes (HP:0100760)2.30912902
55Rough bone trabeculation (HP:0100670)2.30520164
56Triphalangeal thumb (HP:0001199)2.29497696
57Neoplasm of the pancreas (HP:0002894)2.29062475
58Premature graying of hair (HP:0002216)2.28804728
59Atresia of the external auditory canal (HP:0000413)2.28696346
60Choanal atresia (HP:0000453)2.27937202
61Abnormality of glycolysis (HP:0004366)2.26536208
62Horseshoe kidney (HP:0000085)2.25410709
63Tracheoesophageal fistula (HP:0002575)2.24512963
64Abnormality of DNA repair (HP:0003254)2.23906179
65Multiple enchondromatosis (HP:0005701)2.23120553
66Arteriovenous malformation (HP:0100026)2.19613012
67Volvulus (HP:0002580)2.17725472
68Neoplasm of the oral cavity (HP:0100649)2.17094615
69Short 4th metacarpal (HP:0010044)2.13787158
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.13787158
71Neoplasm of striated muscle (HP:0009728)2.11518947
72Cafe-au-lait spot (HP:0000957)2.10908590
73Deep philtrum (HP:0002002)2.10845688
74Proximal placement of thumb (HP:0009623)2.08585969
75Progressive muscle weakness (HP:0003323)2.06889299
76Duplication of thumb phalanx (HP:0009942)2.06657838
77Glioma (HP:0009733)2.05383543
78Deviation of the thumb (HP:0009603)2.04617689
79Facial hemangioma (HP:0000329)2.03645018
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03517022
81Increased serum pyruvate (HP:0003542)1.99452098
82Basal cell carcinoma (HP:0002671)1.99092102
83Prominent nose (HP:0000448)1.95594660
84Abnormality of the astrocytes (HP:0100707)1.93896907
85Astrocytoma (HP:0009592)1.93896907
86Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93842882
87Abnormality of reticulocytes (HP:0004312)1.92496322
88Abnormality of pyrimidine metabolism (HP:0004353)1.92473595
89Septate vagina (HP:0001153)1.92364626
90Slender long bone (HP:0003100)1.91145022
91Morphological abnormality of the inner ear (HP:0011390)1.91013532
92Ureteral duplication (HP:0000073)1.90477289
93Aplasia/Hypoplasia of the earlobes (HP:0009906)1.90212605
94Microretrognathia (HP:0000308)1.89432693
95Cellular immunodeficiency (HP:0005374)1.88482450
96Short middle phalanx of the 5th finger (HP:0004220)1.88035783
97Cleft eyelid (HP:0000625)1.87727678
98Neoplasm of the colon (HP:0100273)1.87227804
99Squamous cell carcinoma (HP:0002860)1.83790859
100High pitched voice (HP:0001620)1.83645317
101Breast aplasia (HP:0100783)1.83550176
102Embryonal neoplasm (HP:0002898)1.82229202
103Facial cleft (HP:0002006)1.81541159
104Abnormality of chromosome segregation (HP:0002916)1.80974907
105Pancytopenia (HP:0001876)1.79748407
106Pallor (HP:0000980)1.78458878
107Acute myeloid leukemia (HP:0004808)1.77945024
108Premature ovarian failure (HP:0008209)1.77393299
109Shawl scrotum (HP:0000049)1.77172787
110Abnormal spermatogenesis (HP:0008669)1.76766911
111Missing ribs (HP:0000921)1.76352003
112Biliary tract neoplasm (HP:0100574)1.75995432
113Aplasia/Hypoplasia of the breasts (HP:0010311)1.75539751
114High anterior hairline (HP:0009890)1.75113956
115Abnormal trabecular bone morphology (HP:0100671)1.74741601
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74575869
117Macrocytic anemia (HP:0001972)1.73549692
118Abnormality of the fetal cardiovascular system (HP:0010948)1.73404409
119Abnormal umbilical cord blood vessels (HP:0011403)1.73404409
120Single umbilical artery (HP:0001195)1.73404409
121Abnormality of abdominal situs (HP:0011620)1.71876397
122Abdominal situs inversus (HP:0003363)1.71876397
123Cerebral hypomyelination (HP:0006808)1.71874003
124Overlapping toe (HP:0001845)1.71747957
125Amaurosis fugax (HP:0100576)1.71237871
126Progressive external ophthalmoplegia (HP:0000590)1.70813074
127Secondary amenorrhea (HP:0000869)1.69600136
128Abnormality of the pons (HP:0007361)1.67642911
129Hypoplasia of the pons (HP:0012110)1.67458963
130Abnormal gallbladder physiology (HP:0012438)1.66653015
131Cholecystitis (HP:0001082)1.66653015
132Megaloblastic anemia (HP:0001889)1.64836749
133Sandal gap (HP:0001852)1.63906780
134Homocystinuria (HP:0002156)1.62634488
135Abnormality of homocysteine metabolism (HP:0010919)1.62634488
136Abnormality of methionine metabolism (HP:0010901)1.58489530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.07826831
2WEE14.41473871
3BUB14.14186383
4TTK3.10080370
5SRPK12.94324698
6NEK22.92854551
7PLK42.84654689
8EIF2AK12.75413219
9ACVR1B2.33605735
10PLK12.29195050
11BRSK22.28256735
12TSSK62.10600492
13MKNK12.07420017
14NEK12.06142773
15ATR2.02995884
16TLK12.00851088
17CDK121.87659010
18CHEK21.87079571
19CDK71.86878261
20PLK31.85296731
21AURKB1.84231873
22VRK11.84128202
23PASK1.80751201
24ZAK1.80409584
25MKNK21.67632243
26EIF2AK31.62598229
27VRK21.56007775
28RPS6KB21.47970576
29STK161.42088962
30CDK41.41307421
31SMG11.40257022
32CHEK11.39426084
33BRSK11.39168905
34CCNB11.37666946
35DYRK31.37119917
36MAP3K81.35693617
37TAF11.34256245
38PDK21.34039232
39STK41.30851943
40AURKA1.30396258
41EPHA21.27988054
42RPS6KA41.25022434
43TGFBR11.20773243
44ATM1.14442504
45TRIM281.13820875
46TESK21.12713767
47EEF2K1.11373654
48NME21.10916473
49STK101.10331734
50BRD41.09821552
51CDK81.06760487
52STK38L1.05973471
53MST40.98461492
54CDK20.98143942
55MST1R0.97695664
56EIF2AK20.94333558
57STK30.92956293
58PIM10.91654055
59BRAF0.90545479
60MELK0.90119150
61NME10.88795819
62* CDK10.78745840
63PAK40.73034686
64CLK10.70389296
65CDK60.68680729
66LATS10.67196528
67ICK0.67007692
68PBK0.65887671
69CSNK2A10.65313639
70SCYL20.65164106
71CSNK2A20.63345663
72ALK0.58546765
73RPS6KA50.57175080
74RAF10.56371403
75CDK30.56144451
76IRAK30.54649627
77CAMK1G0.53456258
78ERBB40.52857005
79YES10.52520776
80PAK10.50635667
81LATS20.49826056
82PRKCI0.47471949
83MAP3K100.46749198
84MET0.43048599
85CAMK1D0.42865361
86AKT30.42766137
87PNCK0.41518946
88PRKDC0.41380312
89KSR20.40030878
90FLT30.39700619
91MAPKAPK50.36676686
92CDK11A0.36020523
93CDK180.35312398
94CDK150.35254881
95MAPKAPK30.33814722
96AKT20.31055029
97AKT10.30946865
98CSNK1E0.30855079
99* MAPK140.30671559
100MTOR0.30668430
101CSNK1D0.29501841
102PLK20.29366202
103CDK90.28430293
104CDK140.27496993
105NEK90.27157048
106DYRK20.26641399
107NUAK10.25383848
108KSR10.24873496
109TAOK20.23372596
110PIM20.22172399
111RPS6KB10.20493513
112NEK60.20352099
113* GSK3B0.20140021
114CSNK1G10.19960656
115STK240.19698788
116MAPK10.18656537
117TESK10.18434121
118MAPK110.18212383
119TEC0.17961207
120BTK0.15771136
121ERBB30.15519934
122CHUK0.14561569
123MAP3K60.14309238
124IRAK40.13824871
125MAP2K30.13471617
126MARK30.13117284
127LRRK20.12932484

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.41941848
2* Mismatch repair_Homo sapiens_hsa034304.54170422
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.69888300
4Homologous recombination_Homo sapiens_hsa034403.59789625
5Base excision repair_Homo sapiens_hsa034103.35677542
6Cell cycle_Homo sapiens_hsa041103.21077107
7Spliceosome_Homo sapiens_hsa030403.20004980
8RNA transport_Homo sapiens_hsa030133.13578692
9Nucleotide excision repair_Homo sapiens_hsa034203.12188803
10RNA polymerase_Homo sapiens_hsa030202.97710782
11One carbon pool by folate_Homo sapiens_hsa006702.88123924
12Fanconi anemia pathway_Homo sapiens_hsa034602.87136735
13Proteasome_Homo sapiens_hsa030502.52112971
14Ribosome_Homo sapiens_hsa030102.45641598
15Pyrimidine metabolism_Homo sapiens_hsa002402.42937823
16Non-homologous end-joining_Homo sapiens_hsa034502.31324717
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28855384
18Basal transcription factors_Homo sapiens_hsa030222.11871112
19RNA degradation_Homo sapiens_hsa030182.08027349
20mRNA surveillance pathway_Homo sapiens_hsa030151.87555296
21p53 signaling pathway_Homo sapiens_hsa041151.79483534
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71387846
23Systemic lupus erythematosus_Homo sapiens_hsa053221.50769414
24Purine metabolism_Homo sapiens_hsa002301.32307260
25Pyruvate metabolism_Homo sapiens_hsa006201.25266418
26Epstein-Barr virus infection_Homo sapiens_hsa051691.11752465
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11159098
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09080671
29Oocyte meiosis_Homo sapiens_hsa041141.08701897
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04452526
31Viral carcinogenesis_Homo sapiens_hsa052031.03438270
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99937878
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98511947
34Herpes simplex infection_Homo sapiens_hsa051680.97912713
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90685276
36HTLV-I infection_Homo sapiens_hsa051660.80780570
37MicroRNAs in cancer_Homo sapiens_hsa052060.78744712
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77631755
39Antigen processing and presentation_Homo sapiens_hsa046120.73634909
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67514622
41Vitamin B6 metabolism_Homo sapiens_hsa007500.67156707
42Selenocompound metabolism_Homo sapiens_hsa004500.66534302
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.65709272
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65108788
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62535809
46Small cell lung cancer_Homo sapiens_hsa052220.62387678
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.62115654
48Folate biosynthesis_Homo sapiens_hsa007900.62106179
49Thyroid cancer_Homo sapiens_hsa052160.61473385
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60594705
51Propanoate metabolism_Homo sapiens_hsa006400.59981123
52Basal cell carcinoma_Homo sapiens_hsa052170.59131646
53TGF-beta signaling pathway_Homo sapiens_hsa043500.58139525
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.57503553
55Alcoholism_Homo sapiens_hsa050340.57392701
56Pentose phosphate pathway_Homo sapiens_hsa000300.56610519
57Fatty acid elongation_Homo sapiens_hsa000620.56385508
58Steroid biosynthesis_Homo sapiens_hsa001000.56036303
59Parkinsons disease_Homo sapiens_hsa050120.55507059
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54908838
61Biosynthesis of amino acids_Homo sapiens_hsa012300.52025942
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51644323
63Hippo signaling pathway_Homo sapiens_hsa043900.51609350
64Legionellosis_Homo sapiens_hsa051340.49434235
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45823051
66Colorectal cancer_Homo sapiens_hsa052100.45350472
67Apoptosis_Homo sapiens_hsa042100.40777350
68Oxidative phosphorylation_Homo sapiens_hsa001900.38606055
69Notch signaling pathway_Homo sapiens_hsa043300.38577449
70Hepatitis B_Homo sapiens_hsa051610.36871636
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36732583
72Measles_Homo sapiens_hsa051620.35134875
73Hedgehog signaling pathway_Homo sapiens_hsa043400.35086396
74Glutathione metabolism_Homo sapiens_hsa004800.34906424
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.31982325
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31302956
77Arginine biosynthesis_Homo sapiens_hsa002200.30686284
78Pathways in cancer_Homo sapiens_hsa052000.29929780
79Prostate cancer_Homo sapiens_hsa052150.28512738
80Adherens junction_Homo sapiens_hsa045200.26622891
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26564605
82N-Glycan biosynthesis_Homo sapiens_hsa005100.25275460
83Influenza A_Homo sapiens_hsa051640.25076073
84Protein export_Homo sapiens_hsa030600.24510398
85Primary immunodeficiency_Homo sapiens_hsa053400.24447876
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24140513
87Bladder cancer_Homo sapiens_hsa052190.23778602
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23458882
89Chronic myeloid leukemia_Homo sapiens_hsa052200.22936767
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22384233
91Huntingtons disease_Homo sapiens_hsa050160.22283128
92Lysine degradation_Homo sapiens_hsa003100.21899035
93Melanoma_Homo sapiens_hsa052180.20206322
94Arachidonic acid metabolism_Homo sapiens_hsa005900.19286161
95Arginine and proline metabolism_Homo sapiens_hsa003300.18743815
96Viral myocarditis_Homo sapiens_hsa054160.17973185
97Wnt signaling pathway_Homo sapiens_hsa043100.17958989
98HIF-1 signaling pathway_Homo sapiens_hsa040660.17856416
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17707247
100Shigellosis_Homo sapiens_hsa051310.16472801
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15816972
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15271723
103Fatty acid metabolism_Homo sapiens_hsa012120.15015146
104Hematopoietic cell lineage_Homo sapiens_hsa046400.14791710
105Alzheimers disease_Homo sapiens_hsa050100.14777132
106Glioma_Homo sapiens_hsa052140.13456782
107Fructose and mannose metabolism_Homo sapiens_hsa000510.13204389
108Sulfur relay system_Homo sapiens_hsa041220.13180440
109FoxO signaling pathway_Homo sapiens_hsa040680.13149425
110Pancreatic cancer_Homo sapiens_hsa052120.12301134
111Renin-angiotensin system_Homo sapiens_hsa046140.11740218
112Carbon metabolism_Homo sapiens_hsa012000.10293068
113Metabolic pathways_Homo sapiens_hsa011000.10025853
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.09537337
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09091564
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09045330
117Non-small cell lung cancer_Homo sapiens_hsa052230.08732912
118mTOR signaling pathway_Homo sapiens_hsa041500.07563327
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.07432894
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07302595
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07300793
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06959733
123Galactose metabolism_Homo sapiens_hsa000520.06778980
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06771871

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