EXOC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.36096827
2activated T cell proliferation (GO:0050798)4.58423703
3nerve growth factor signaling pathway (GO:0038180)4.54378200
4neural tube formation (GO:0001841)4.30744385
5nucleobase catabolic process (GO:0046113)4.24912513
6establishment of mitochondrion localization (GO:0051654)4.10302632
7establishment of protein localization to Golgi (GO:0072600)4.03467869
8protein targeting to Golgi (GO:0000042)4.00524862
9retrograde transport, vesicle recycling within Golgi (GO:0000301)3.56202579
10negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.48449952
11presynaptic membrane assembly (GO:0097105)3.43774933
12protein localization to cilium (GO:0061512)3.42951640
13protein targeting to lysosome (GO:0006622)3.42775693
14establishment of protein localization to vacuole (GO:0072666)3.42775693
15protein targeting to vacuole (GO:0006623)3.42775693
16protein localization to Golgi apparatus (GO:0034067)3.36554638
17positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.25989056
18mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.25989056
19positive regulation of growth hormone secretion (GO:0060124)3.24160106
20axonal fasciculation (GO:0007413)3.23374245
21negative regulation of neurotransmitter secretion (GO:0046929)3.22715615
22tyrosine phosphorylation of STAT protein (GO:0007260)3.18317724
23kinetochore assembly (GO:0051382)3.16432089
24negative regulation of mast cell activation (GO:0033004)3.14791248
25centriole replication (GO:0007099)3.14094072
26regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.07324447
27Golgi to endosome transport (GO:0006895)3.05987931
28presynaptic membrane organization (GO:0097090)3.05590316
29kinetochore organization (GO:0051383)3.03863231
30tachykinin receptor signaling pathway (GO:0007217)3.02377397
31negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01798627
32gamma-aminobutyric acid transport (GO:0015812)3.01636980
33ribonucleoprotein complex disassembly (GO:0032988)2.99270250
34behavioral response to ethanol (GO:0048149)2.95605100
35neuron recognition (GO:0008038)2.93845124
36intra-Golgi vesicle-mediated transport (GO:0006891)2.91398164
37postsynaptic membrane organization (GO:0001941)2.90372373
38microtubule nucleation (GO:0007020)2.89612486
39intraciliary transport (GO:0042073)2.88589722
40negative regulation of neurotransmitter transport (GO:0051589)2.85653639
41organelle transport along microtubule (GO:0072384)2.85124362
42neuron remodeling (GO:0016322)2.81991636
43positive regulation of action potential (GO:0045760)2.81423639
44regulation of cilium movement (GO:0003352)2.81331480
45regulation of action potential (GO:0098900)2.80976672
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.79981116
47cellular response to nerve growth factor stimulus (GO:1990090)2.79106777
48response to nerve growth factor (GO:1990089)2.79106777
49ribosomal small subunit biogenesis (GO:0042274)2.78782477
50negative regulation of interleukin-17 production (GO:0032700)2.77975655
51centriole assembly (GO:0098534)2.76369409
52negative regulation of DNA-dependent DNA replication (GO:2000104)2.75672877
53heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.74310913
54platelet dense granule organization (GO:0060155)2.73555797
55cell wall macromolecule catabolic process (GO:0016998)2.72539834
56microtubule depolymerization (GO:0007019)2.70861744
57neuron maturation (GO:0042551)2.70830961
58central nervous system myelination (GO:0022010)2.69320155
59axon ensheathment in central nervous system (GO:0032291)2.69320155
60DNA methylation involved in gamete generation (GO:0043046)2.69096209
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68631738
62mitochondrion transport along microtubule (GO:0047497)2.68631738
63synapse assembly (GO:0007416)2.68031636
64calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.68003447
65CENP-A containing nucleosome assembly (GO:0034080)2.66767555
66early endosome to late endosome transport (GO:0045022)2.66189009
67neuron cell-cell adhesion (GO:0007158)2.65342875
68substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.63950220
69substrate-independent telencephalic tangential migration (GO:0021826)2.63950220
70glutamate receptor signaling pathway (GO:0007215)2.60154219
71DNA damage response, detection of DNA damage (GO:0042769)2.59043589
72long-chain fatty acid biosynthetic process (GO:0042759)2.57388362
73chromatin remodeling at centromere (GO:0031055)2.57268718
74positive regulation of mitochondrial fission (GO:0090141)2.56562157
75cerebral cortex radially oriented cell migration (GO:0021799)2.56421712
76phospholipid translocation (GO:0045332)2.56394366
77lipid translocation (GO:0034204)2.56394366
78regulation of nuclear cell cycle DNA replication (GO:0033262)2.54644706
79ribosomal large subunit biogenesis (GO:0042273)2.54027299
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.53368241
81termination of RNA polymerase III transcription (GO:0006386)2.53368241
82epithelial cell differentiation involved in kidney development (GO:0035850)2.52849830
83dendrite morphogenesis (GO:0048813)2.52602467
84neuronal action potential propagation (GO:0019227)2.52104751
85vesicle transport along microtubule (GO:0047496)2.50557783
86dendrite development (GO:0016358)2.50258554
87proline transport (GO:0015824)2.50218670
88striatum development (GO:0021756)2.50110440
89positive regulation of protein homodimerization activity (GO:0090073)2.49966001
90nucleotide transmembrane transport (GO:1901679)2.49931917
91Rap protein signal transduction (GO:0032486)2.48087012
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47717319
93regulation of sarcomere organization (GO:0060297)2.45506262
94cilium assembly (GO:0042384)2.43865962
95positive regulation of vesicle fusion (GO:0031340)2.43656430
96positive regulation of oligodendrocyte differentiation (GO:0048714)2.43608613
97RNA capping (GO:0036260)2.42249185
987-methylguanosine RNA capping (GO:0009452)2.42249185
99cellular response to leptin stimulus (GO:0044320)2.41971792
100central nervous system neuron axonogenesis (GO:0021955)2.41872332
101GTP biosynthetic process (GO:0006183)2.41528773
102cilium organization (GO:0044782)2.40587390
103regulation of axon regeneration (GO:0048679)2.40468928
104regulation of neuron projection regeneration (GO:0070570)2.40468928
105regulation of synaptic vesicle exocytosis (GO:2000300)2.40253955
106glycosphingolipid biosynthetic process (GO:0006688)2.39977422
107ganglion development (GO:0061548)2.39666631
108seminiferous tubule development (GO:0072520)2.39519115
109negative regulation of heart rate (GO:0010459)2.39463730
110protein K6-linked ubiquitination (GO:0085020)2.38846999
111negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.38627663
112negative regulation of T-helper cell differentiation (GO:0045623)2.38627663
113monoubiquitinated protein deubiquitination (GO:0035520)2.38104816
114adaptation of signaling pathway (GO:0023058)2.37968318
1157-methylguanosine mRNA capping (GO:0006370)2.37609272
116retinal cone cell development (GO:0046549)2.37138648
117photoreceptor cell maintenance (GO:0045494)2.37122963
118developmental pigmentation (GO:0048066)2.35979843
119regulation of growth hormone secretion (GO:0060123)2.35809661
120negative regulation of execution phase of apoptosis (GO:1900118)2.35226670
121transcription elongation from RNA polymerase I promoter (GO:0006362)2.34266329
122regulation of MHC class II biosynthetic process (GO:0045346)2.33905799
123protein localization to lysosome (GO:0061462)2.33676454
124startle response (GO:0001964)2.32851353
125regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.31476781
126DNA replication checkpoint (GO:0000076)2.31060900
127DNA ligation (GO:0006266)2.30145904
128preassembly of GPI anchor in ER membrane (GO:0016254)2.28868369
129deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.27291602
130regulation of histone H3-K27 methylation (GO:0061085)2.26730194
131telomere maintenance via semi-conservative replication (GO:0032201)2.25618043
132proteasome assembly (GO:0043248)2.24636159
133maturation of 5.8S rRNA (GO:0000460)2.24157468
134termination of RNA polymerase I transcription (GO:0006363)2.24044131
135telomere maintenance via recombination (GO:0000722)2.23769565
136meiotic chromosome segregation (GO:0045132)2.22361308
137protein neddylation (GO:0045116)2.21127987
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.20600359
139spliceosomal complex assembly (GO:0000245)2.20446672
140DNA double-strand break processing (GO:0000729)2.20290023
141piRNA metabolic process (GO:0034587)2.20270091
142deoxyribonucleotide biosynthetic process (GO:0009263)2.20120060
143mitotic recombination (GO:0006312)2.19664865
144histone H3-K4 trimethylation (GO:0080182)2.19581474
145regulation of development, heterochronic (GO:0040034)2.19524448
146nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.19188365
147protein heterotetramerization (GO:0051290)2.19064114
148regulation of timing of cell differentiation (GO:0048505)2.18131483
149DNA synthesis involved in DNA repair (GO:0000731)2.16014934
150microtubule polymerization or depolymerization (GO:0031109)2.15508192
151regulation of respiratory system process (GO:0044065)2.15484282
152nonmotile primary cilium assembly (GO:0035058)2.14420109
153regulation of double-strand break repair via homologous recombination (GO:0010569)2.14215925
154DNA replication-independent nucleosome assembly (GO:0006336)2.14056725
155DNA replication-independent nucleosome organization (GO:0034724)2.14056725
156regulation of pigment cell differentiation (GO:0050932)2.13617383
157regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.11535846
158amino acid import (GO:0043090)2.10978582
159L-amino acid import (GO:0043092)2.10075701
160regulation of respiratory gaseous exchange (GO:0043576)2.09961652
161histone exchange (GO:0043486)2.09756325
162DNA replication initiation (GO:0006270)2.09289010
163microtubule anchoring (GO:0034453)2.06743597
164limb bud formation (GO:0060174)2.05964322
165maturation of SSU-rRNA (GO:0030490)2.05173231
166RNA destabilization (GO:0050779)2.04989515
167female gonad development (GO:0008585)2.04780906
168ionotropic glutamate receptor signaling pathway (GO:0035235)2.03115814
169transcription-coupled nucleotide-excision repair (GO:0006283)2.00842971
170GPI anchor biosynthetic process (GO:0006506)2.00640332
171righting reflex (GO:0060013)2.00374431
172DNA-dependent DNA replication (GO:0006261)1.99602211
173axoneme assembly (GO:0035082)1.98308088
174spindle checkpoint (GO:0031577)1.97893978
175regulation of mitotic spindle checkpoint (GO:1903504)1.96708577
176regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)1.96708577
177UTP biosynthetic process (GO:0006228)1.96418116
178positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)1.95780764
179oogenesis (GO:0048477)1.95447743
180deoxyribonucleoside triphosphate metabolic process (GO:0009200)1.94827674
181generation of neurons (GO:0048699)1.94748622
182keratinocyte development (GO:0003334)1.94277288
183DNA integration (GO:0015074)1.93807468
184mismatch repair (GO:0006298)1.93019665
185interkinetic nuclear migration (GO:0022027)1.93009977
186maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)1.92900362
187dendritic cell chemotaxis (GO:0002407)1.92114596
188positive regulation of meiosis (GO:0045836)1.90519012
189telomere maintenance via telomere lengthening (GO:0010833)1.90313605
190intra-S DNA damage checkpoint (GO:0031573)1.89513602
191regulation of meiosis I (GO:0060631)1.89279224
192attachment of spindle microtubules to kinetochore (GO:0008608)1.88409772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.79893888
2GBX2_23144817_ChIP-Seq_PC3_Human3.02840548
3EZH2_22144423_ChIP-Seq_EOC_Human2.84402839
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55266629
5ZNF274_21170338_ChIP-Seq_K562_Hela2.47927048
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.40467995
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.38815550
8VDR_22108803_ChIP-Seq_LS180_Human2.28793566
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25556848
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23649777
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23271012
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20647720
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20043722
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13630501
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11173233
16IGF1R_20145208_ChIP-Seq_DFB_Human2.09032294
17FUS_26573619_Chip-Seq_HEK293_Human2.08903349
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06768555
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04542460
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03963236
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96485897
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94080077
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86580319
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80928027
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79201098
26TAF15_26573619_Chip-Seq_HEK293_Human1.76822898
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.75977411
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.69202259
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.68428591
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66224627
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65282904
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62733667
33EWS_26573619_Chip-Seq_HEK293_Human1.61566382
34EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59057602
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57824763
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57680792
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57477179
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.57068539
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.56359484
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55393777
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54853598
42SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51298744
43P53_22387025_ChIP-Seq_ESCs_Mouse1.50049914
44ER_23166858_ChIP-Seq_MCF-7_Human1.49929837
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.49125426
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49035922
47CBP_20019798_ChIP-Seq_JUKART_Human1.49035922
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.49032170
49P300_18555785_Chip-Seq_ESCs_Mouse1.48568027
50RNF2_27304074_Chip-Seq_NSC_Mouse1.47835025
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47138994
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.46381401
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.46160488
54P300_19829295_ChIP-Seq_ESCs_Human1.45183161
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44372920
56* GABP_17652178_ChIP-ChIP_JURKAT_Human1.43709765
57NMYC_18555785_Chip-Seq_ESCs_Mouse1.43520486
58AR_25329375_ChIP-Seq_VCAP_Human1.43492319
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.42444048
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.42302705
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.40225322
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40149333
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40149333
64BCAT_22108803_ChIP-Seq_LS180_Human1.37313542
65ELK1_19687146_ChIP-ChIP_HELA_Human1.34339134
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33976553
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.32658078
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32477366
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.32150078
70RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31639571
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31390652
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31031423
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29958575
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.29326443
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28479737
76ZFX_18555785_Chip-Seq_ESCs_Mouse1.28009049
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.27440714
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.25259582
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25131828
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.24371508
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21886553
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.20989814
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20903230
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20831384
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20006812
86CTCF_18555785_Chip-Seq_ESCs_Mouse1.19693883
87LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19501390
88KDM2B_26808549_Chip-Seq_REH_Human1.18431660
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18192262
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17570299
91TP53_16413492_ChIP-PET_HCT116_Human1.17240782
92SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17024067
93IRF1_19129219_ChIP-ChIP_H3396_Human1.16574878
94FOXM1_23109430_ChIP-Seq_U2OS_Human1.15070126
95ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14952826
96PU1_27457419_Chip-Seq_LIVER_Mouse1.14595589
97TP53_18474530_ChIP-ChIP_U2OS_Human1.13964879
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13058265
99AR_21572438_ChIP-Seq_LNCaP_Human1.12820346
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12555401
101JUN_21703547_ChIP-Seq_K562_Human1.12182793
102TCF4_22108803_ChIP-Seq_LS180_Human1.12093177
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11484075
104CJUN_26792858_Chip-Seq_BT549_Human1.10662875
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10343226
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.10034311
107KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09178810
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08574340
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08574340
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07860660
111EZH2_27304074_Chip-Seq_ESCs_Mouse1.07796895
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07399506
113HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07287650
114* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07144145
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.06347083
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04625556
117* SMAD3_21741376_ChIP-Seq_EPCs_Human1.04069467
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03260661
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02818473
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02433954
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02359629
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02210047
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01996793
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01596010
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01064009
126SMAD4_21799915_ChIP-Seq_A2780_Human1.00394507
127VDR_23849224_ChIP-Seq_CD4+_Human0.99061309
128* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98527792
129CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97884177
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97492369
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.96963081
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.94547773
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92966164
134STAT3_23295773_ChIP-Seq_U87_Human0.91237366
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91147476
136MYC_18940864_ChIP-ChIP_HL60_Human0.90526688
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90139297
138ETS1_20019798_ChIP-Seq_JURKAT_Human0.89973197
139* TCF4_23295773_ChIP-Seq_U87_Human0.89736414
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88197655
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.87815942
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87538512
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86865849
144RUNX2_22187159_ChIP-Seq_PCA_Human0.86504977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.42265110
2MP0003136_yellow_coat_color3.36114407
3MP0003880_abnormal_central_pattern3.22029959
4MP0005409_darkened_coat_color3.10363513
5MP0006054_spinal_hemorrhage2.66787031
6MP0003724_increased_susceptibility_to2.53241795
7MP0006292_abnormal_olfactory_placode2.46457588
8MP0008877_abnormal_DNA_methylation2.33694067
9MP0000015_abnormal_ear_pigmentation2.25292014
10MP0002822_catalepsy2.19210827
11MP0005423_abnormal_somatic_nervous2.17736905
12MP0003787_abnormal_imprinting2.15724139
13MP0009379_abnormal_foot_pigmentation2.12605732
14MP0005174_abnormal_tail_pigmentation2.05103230
15MP0005171_absent_coat_pigmentation2.02980846
16MP0004381_abnormal_hair_follicle2.02494340
17MP0000569_abnormal_digit_pigmentation1.85888064
18MP0010094_abnormal_chromosome_stability1.79051541
19MP0002102_abnormal_ear_morphology1.77553978
20MP0001986_abnormal_taste_sensitivity1.77527286
21MP0004885_abnormal_endolymph1.71469257
22MP0008058_abnormal_DNA_repair1.69369233
23MP0003221_abnormal_cardiomyocyte_apopto1.67646051
24MP0000566_synostosis1.64966404
25MP0008057_abnormal_DNA_replication1.63920367
26MP0003111_abnormal_nucleus_morphology1.60206532
27MP0000427_abnormal_hair_cycle1.57853950
28MP0000516_abnormal_urinary_system1.56839367
29MP0005367_renal/urinary_system_phenotyp1.56839367
30MP0001968_abnormal_touch/_nociception1.56656626
31MP0003693_abnormal_embryo_hatching1.56229161
32MP0001542_abnormal_bone_strength1.53675223
33MP0004883_abnormal_blood_vessel1.52193276
34MP0003633_abnormal_nervous_system1.51298600
35MP0002277_abnormal_respiratory_mucosa1.49160979
36MP0000465_gastrointestinal_hemorrhage1.46291652
37MP0001879_abnormal_lymphatic_vessel1.45555696
38MP0003183_abnormal_peptide_metabolism1.44715464
39MP0002735_abnormal_chemical_nociception1.41892708
40MP0004811_abnormal_neuron_physiology1.40823257
41MP0001486_abnormal_startle_reflex1.40222438
42MP0003718_maternal_effect1.40222097
43MP0003385_abnormal_body_wall1.38675991
44MP0002095_abnormal_skin_pigmentation1.38252069
45MP0003315_abnormal_perineum_morphology1.36732698
46MP0009046_muscle_twitch1.34771127
47MP0002638_abnormal_pupillary_reflex1.34161389
48MP0010368_abnormal_lymphatic_system1.33546759
49MP0004742_abnormal_vestibular_system1.32371035
50MP0000778_abnormal_nervous_system1.30569256
51MP0001529_abnormal_vocalization1.30126910
52MP0004142_abnormal_muscle_tone1.29075998
53MP0003786_premature_aging1.28586197
54MP0001905_abnormal_dopamine_level1.26301296
55MP0003077_abnormal_cell_cycle1.25370209
56MP0008932_abnormal_embryonic_tissue1.23784631
57MP0003121_genomic_imprinting1.23035853
58MP0008995_early_reproductive_senescence1.22466223
59MP0005084_abnormal_gallbladder_morpholo1.22319326
60MP0000372_irregular_coat_pigmentation1.21304270
61MP0006276_abnormal_autonomic_nervous1.20152753
62MP0003303_peritoneal_inflammation1.17949844
63MP0003941_abnormal_skin_development1.16948887
64MP0005397_hematopoietic_system_phenotyp1.15853626
65MP0001545_abnormal_hematopoietic_system1.15853626
66MP0003690_abnormal_glial_cell1.15764637
67MP0002751_abnormal_autonomic_nervous1.15583724
68MP0009745_abnormal_behavioral_response1.14977867
69MP0003938_abnormal_ear_development1.14901147
70MP0005386_behavior/neurological_phenoty1.14551863
71MP0003631_nervous_system_phenotype1.14456684
72MP0002736_abnormal_nociception_after1.12613836
73MP0002272_abnormal_nervous_system1.12145758
74MP0009785_altered_susceptibility_to1.12046764
75MP0002734_abnormal_mechanical_nocicepti1.11994265
76MP0002234_abnormal_pharynx_morphology1.10118305
77MP0008007_abnormal_cellular_replicative1.08992971
78MP0002067_abnormal_sensory_capabilities1.08907258
79MP0001485_abnormal_pinna_reflex1.08317108
80MP0002572_abnormal_emotion/affect_behav1.07379114
81MP0003635_abnormal_synaptic_transmissio1.07219903
82MP0003950_abnormal_plasma_membrane1.07210828
83MP0005248_abnormal_Harderian_gland1.04765351
84MP0004043_abnormal_pH_regulation1.04480047
85MP0009764_decreased_sensitivity_to1.04337494
86MP0005253_abnormal_eye_physiology1.02804289
87MP0006072_abnormal_retinal_apoptosis1.02470738
88MP0002064_seizures1.01429197
89MP0004270_analgesia1.00882753
90MP0003937_abnormal_limbs/digits/tail_de1.00776284
91MP0004859_abnormal_synaptic_plasticity1.00091961
92MP0002177_abnormal_outer_ear0.99743429
93MP0001764_abnormal_homeostasis0.99186102
94MP0002184_abnormal_innervation0.98179639
95MP0005075_abnormal_melanosome_morpholog0.98154157
96MP0002909_abnormal_adrenal_gland0.97528345
97MP0005551_abnormal_eye_electrophysiolog0.96602286
98MP0001501_abnormal_sleep_pattern0.96534592
99MP0000026_abnormal_inner_ear0.95209529
100MP0005164_abnormal_response_to0.94946558
101MP0002938_white_spotting0.94849473
102MP0002210_abnormal_sex_determination0.93689226
103MP0008260_abnormal_autophagy0.93213704
104MP0001963_abnormal_hearing_physiology0.92452443
105MP0001440_abnormal_grooming_behavior0.91506540
106MP0010386_abnormal_urinary_bladder0.90904989
107MP0002332_abnormal_exercise_endurance0.89656941
108MP0003656_abnormal_erythrocyte_physiolo0.88837884
109MP0002009_preneoplasia0.87701106
110MP0000955_abnormal_spinal_cord0.87612459
111MP0001970_abnormal_pain_threshold0.86340712
112MP0002557_abnormal_social/conspecific_i0.86129982
113MP0002928_abnormal_bile_duct0.85178158
114MP0003632_abnormal_nervous_system0.85052704
115MP0002752_abnormal_somatic_nervous0.84602845
116MP0000631_abnormal_neuroendocrine_gland0.84559498
117MP0002063_abnormal_learning/memory/cond0.83099722
118MP0005499_abnormal_olfactory_system0.82216622
119MP0005394_taste/olfaction_phenotype0.82216622
120MP0003634_abnormal_glial_cell0.79613417
121MP0002882_abnormal_neuron_morphology0.79163335
122MP0004215_abnormal_myocardial_fiber0.78800604
123MP0001186_pigmentation_phenotype0.78000304
124MP0001177_atelectasis0.77945191
125MP0002233_abnormal_nose_morphology0.77406449
126MP0005645_abnormal_hypothalamus_physiol0.77079985
127MP0008789_abnormal_olfactory_epithelium0.77034976
128MP0002229_neurodegeneration0.76206823
129MP0002066_abnormal_motor_capabilities/c0.76202073
130MP0000383_abnormal_hair_follicle0.75908588
131MP0006082_CNS_inflammation0.75903511
132MP0002163_abnormal_gland_morphology0.75842644
133MP0000049_abnormal_middle_ear0.74551300
134MP0001929_abnormal_gametogenesis0.72768577
135MP0001835_abnormal_antigen_presentation0.71798199
136MP0001958_emphysema0.71398047
137MP0000920_abnormal_myelination0.71269843
138MP0004484_altered_response_of0.71037291
139MP0003698_abnormal_male_reproductive0.70845327
140MP0001919_abnormal_reproductive_system0.68721680
141MP0003890_abnormal_embryonic-extraembry0.68538176
142MP0002733_abnormal_thermal_nociception0.68122179
143MP0003861_abnormal_nervous_system0.65384827
144MP0001145_abnormal_male_reproductive0.65187373
145MP0003755_abnormal_palate_morphology0.64926850
146MP0001984_abnormal_olfaction0.64711691
147MP0002075_abnormal_coat/hair_pigmentati0.64609616
148MP0004924_abnormal_behavior0.63979866

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.94748791
2Hip dysplasia (HP:0001385)4.38673385
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83129705
4Chromsome breakage (HP:0040012)3.75155656
5Drooling (HP:0002307)3.62169504
6Excessive salivation (HP:0003781)3.45973950
7Papillary thyroid carcinoma (HP:0002895)3.25286145
8Degeneration of the lateral corticospinal tracts (HP:0002314)3.23460858
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.23460858
10Disinhibition (HP:0000734)3.20294813
11Tubulointerstitial nephritis (HP:0001970)3.19435526
12Amyotrophic lateral sclerosis (HP:0007354)3.15549165
13Genital tract atresia (HP:0001827)2.92371393
14Vaginal atresia (HP:0000148)2.89971973
15Birth length less than 3rd percentile (HP:0003561)2.87635086
16Abnormality of the corticospinal tract (HP:0002492)2.87504089
17Poor coordination (HP:0002370)2.85628941
18Duplicated collecting system (HP:0000081)2.82339219
19Inappropriate behavior (HP:0000719)2.74250778
20Abnormal hair whorl (HP:0010721)2.67641884
21Widely spaced teeth (HP:0000687)2.59500992
22Abnormality of the renal collecting system (HP:0004742)2.56352386
23Atonic seizures (HP:0010819)2.53411348
24Focal seizures (HP:0007359)2.52184021
25Abnormality of salivation (HP:0100755)2.48545774
26Polyphagia (HP:0002591)2.48508663
27Thyroid carcinoma (HP:0002890)2.45128680
28Pachygyria (HP:0001302)2.43792321
29Thyroiditis (HP:0100646)2.41312463
30Ectopic kidney (HP:0000086)2.37750089
31Metaphyseal dysplasia (HP:0100255)2.37561036
32Mutism (HP:0002300)2.35293185
33Aplasia/Hypoplasia of the lens (HP:0008063)2.33290471
34Meckel diverticulum (HP:0002245)2.33116071
35Prostate neoplasm (HP:0100787)2.30405142
36Reticulocytopenia (HP:0001896)2.29431018
37Specific learning disability (HP:0001328)2.28602755
38Breast hypoplasia (HP:0003187)2.27532130
39Esotropia (HP:0000565)2.26661945
40Abnormal ciliary motility (HP:0012262)2.25979581
41Abnormality of the preputium (HP:0100587)2.24835222
42Abnormality of chromosome stability (HP:0003220)2.24630137
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.22074579
44Abnormality of the renal medulla (HP:0100957)2.21465230
45Aplasia/Hypoplasia of the earlobes (HP:0009906)2.21165792
46Tubulointerstitial abnormality (HP:0001969)2.20045041
47Supernumerary spleens (HP:0009799)2.19632975
48Septo-optic dysplasia (HP:0100842)2.19503274
49Abnormality of the ileum (HP:0001549)2.15765171
50Gaze-evoked nystagmus (HP:0000640)2.13471254
51Abnormality of the septum pellucidum (HP:0007375)2.12453522
52True hermaphroditism (HP:0010459)2.11922734
53Chronic hepatic failure (HP:0100626)2.11369903
54Impaired vibration sensation in the lower limbs (HP:0002166)2.10654607
55Febrile seizures (HP:0002373)2.10459691
56Absent septum pellucidum (HP:0001331)2.08713244
57Renal cortical cysts (HP:0000803)2.07884798
58Progressive external ophthalmoplegia (HP:0000590)2.07604673
59Insidious onset (HP:0003587)2.07289346
60Termporal pattern (HP:0011008)2.07289346
61Cortical dysplasia (HP:0002539)2.05156910
62Abolished electroretinogram (ERG) (HP:0000550)2.05002194
63Volvulus (HP:0002580)2.04324855
64Stomach cancer (HP:0012126)2.02720483
65Atrophy/Degeneration involving motor neurons (HP:0007373)2.02583480
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01561470
67Narrow forehead (HP:0000341)2.00699901
68Lower limb muscle weakness (HP:0007340)2.00222156
69Triphalangeal thumb (HP:0001199)1.99385730
70Vitreoretinal degeneration (HP:0000655)1.98741560
71Oculomotor apraxia (HP:0000657)1.98646316
72Hepatoblastoma (HP:0002884)1.98516935
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98444335
74Hypochromic microcytic anemia (HP:0004840)1.97553027
75Medial flaring of the eyebrow (HP:0010747)1.96528284
76Agitation (HP:0000713)1.96106192
77Decreased testicular size (HP:0008734)1.95657894
78Abnormality of incisor morphology (HP:0011063)1.95565838
79T lymphocytopenia (HP:0005403)1.94779462
80Pancreatic cysts (HP:0001737)1.92539755
81Clubbing of toes (HP:0100760)1.90868328
82Adactyly (HP:0009776)1.90387067
83Barrel-shaped chest (HP:0001552)1.89713553
84Absent radius (HP:0003974)1.89565144
85Diminished motivation (HP:0000745)1.88700321
86Parakeratosis (HP:0001036)1.88238603
87Abnormal lung lobation (HP:0002101)1.88144376
88Abnormality of the metopic suture (HP:0005556)1.86825312
89Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86457347
90Intention tremor (HP:0002080)1.86268529
91Absent forearm bone (HP:0003953)1.85644813
92Aplasia involving forearm bones (HP:0009822)1.85644813
93Pancreatic fibrosis (HP:0100732)1.85308846
94Urinary urgency (HP:0000012)1.84834602
95Apathy (HP:0000741)1.84120579
96Short foot (HP:0001773)1.83296124
97Broad foot (HP:0001769)1.82868270
98Spondylolisthesis (HP:0003302)1.82837146
99Obstructive lung disease (HP:0006536)1.82537295
100Chronic obstructive pulmonary disease (HP:0006510)1.82537295
101Abnormality of midbrain morphology (HP:0002418)1.82237115
102Molar tooth sign on MRI (HP:0002419)1.82237115
103Abnormality of liposaccharide metabolism (HP:0010968)1.81862170
104Abnormality of glycosphingolipid metabolism (HP:0004343)1.81862170
105Abnormality of glycolipid metabolism (HP:0010969)1.81862170
106Hematochezia (HP:0002573)1.81833504
107Thyroid-stimulating hormone excess (HP:0002925)1.81738192
108Patellar aplasia (HP:0006443)1.81014193
109Focal motor seizures (HP:0011153)1.80333601
110Abnormal respiratory epithelium morphology (HP:0012253)1.80088905
111Abnormal respiratory motile cilium morphology (HP:0005938)1.80088905
112Hypoplasia of the corpus callosum (HP:0002079)1.79906638
113Asplenia (HP:0001746)1.79774641
114Abnormal respiratory motile cilium physiology (HP:0012261)1.79288373
115Abnormality of the labia minora (HP:0012880)1.79151842
116Retrobulbar optic neuritis (HP:0100654)1.79001563
117Optic neuritis (HP:0100653)1.79001563
118Lip pit (HP:0100267)1.78571130
119Action tremor (HP:0002345)1.77954616
120Optic nerve hypoplasia (HP:0000609)1.77517802
121Abnormality of macular pigmentation (HP:0008002)1.77239137
122Dyskinesia (HP:0100660)1.76925190
123Abnormality of DNA repair (HP:0003254)1.75938894
124Attenuation of retinal blood vessels (HP:0007843)1.75654111
125Curly hair (HP:0002212)1.75570155
126Dynein arm defect of respiratory motile cilia (HP:0012255)1.75348517
127Absent/shortened dynein arms (HP:0200106)1.75348517
128Anencephaly (HP:0002323)1.75206944
129Abnormality of the columella (HP:0009929)1.74948255
130Abnormality of T cell number (HP:0011839)1.74890045
131Disproportionate short-trunk short stature (HP:0003521)1.74708100
132Preaxial hand polydactyly (HP:0001177)1.74418888
133Gait imbalance (HP:0002141)1.74318855
134Neoplasm of the adrenal cortex (HP:0100641)1.74307252
135Abnormality of the axillary hair (HP:0100134)1.74238967
136Abnormality of secondary sexual hair (HP:0009888)1.74238967
137Conjunctival telangiectasia (HP:0000524)1.73908791
138Nephronophthisis (HP:0000090)1.73670781
139Large earlobe (HP:0009748)1.73662180
140Bony spicule pigmentary retinopathy (HP:0007737)1.73064392
141Short tibia (HP:0005736)1.72291266
142Dysdiadochokinesis (HP:0002075)1.71670876
143Small intestinal stenosis (HP:0012848)1.71537271
144Duodenal stenosis (HP:0100867)1.71537271
145Pendular nystagmus (HP:0012043)1.70752405
146Aganglionic megacolon (HP:0002251)1.70717388
147Postaxial hand polydactyly (HP:0001162)1.70235099
148B lymphocytopenia (HP:0010976)1.69940922
149Progressive cerebellar ataxia (HP:0002073)1.69760661
150Absent thumb (HP:0009777)1.67918716
151Broad-based gait (HP:0002136)1.67816706
152Microvesicular hepatic steatosis (HP:0001414)1.66820882
153Aplasia/Hypoplasia of the patella (HP:0006498)1.66165330
154Capillary hemangiomas (HP:0005306)1.65556897
155Nephrogenic diabetes insipidus (HP:0009806)1.62748122
156Congenital primary aphakia (HP:0007707)1.62652103
157Aplasia/Hypoplasia of the spleen (HP:0010451)1.62537406
158Median cleft lip (HP:0000161)1.61489301
159Atelectasis (HP:0100750)1.61328332
160Aplasia/Hypoplasia of the sacrum (HP:0008517)1.60555322
161Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.58838031
162Sex reversal (HP:0012245)1.58822923
163Abnormal sex determination (HP:0012244)1.58822923
164Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.56081149
165Horseshoe kidney (HP:0000085)1.55940006
166Duplication of thumb phalanx (HP:0009942)1.55637032
167Abnormality of the carotid arteries (HP:0005344)1.55499932
168Short thumb (HP:0009778)1.54609261
169Dyschromatopsia (HP:0007641)1.54352742
170Type I transferrin isoform profile (HP:0003642)1.52900176
171Cupped ear (HP:0000378)1.52229069
172Nephroblastoma (Wilms tumor) (HP:0002667)1.52190039
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.51690321
174Bone marrow hypocellularity (HP:0005528)1.51362902
175Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.50333725
176Absent speech (HP:0001344)1.50224137
177Aplasia/hypoplasia of the uterus (HP:0008684)1.50131433
178Abnormality of the incisor (HP:0000676)1.47673367
179Intestinal atresia (HP:0011100)1.47452703
180Male pseudohermaphroditism (HP:0000037)1.46637788
181Myelodysplasia (HP:0002863)1.45244416
182Nonprogressive disorder (HP:0003680)1.45241072
183Pulmonary fibrosis (HP:0002206)1.45148002
184Abnormality of the duodenum (HP:0002246)1.45113100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.94117851
2IRAK32.82870599
3SRPK12.71246527
4TNIK2.59040870
5FRK2.58293112
6EPHA32.53209532
7MKNK22.47006802
8IRAK42.39506480
9MARK12.32268896
10PLK42.29375197
11PBK2.21232973
12WNK32.17110052
13CAMKK22.14622406
14MKNK11.97881803
15TLK11.94212180
16MAP2K71.91765788
17MAP2K41.85550380
18MAP3K121.82871941
19PRKD31.82296164
20BMPR1B1.81141660
21BUB11.77418408
22ACVR1B1.76245764
23CLK11.69173278
24ZAK1.63693793
25MAP3K61.62568203
26STK161.62524684
27IRAK21.57287763
28PAK31.52230018
29STK38L1.51896912
30VRK11.43870612
31YES11.43655196
32TXK1.39943054
33TRIM281.37021318
34BMPR21.34501407
35NTRK31.34215483
36TGFBR21.33841455
37BLK1.31553738
38NEK61.30204064
39PNCK1.29844066
40MAPK131.28389699
41EIF2AK21.26283618
42CDK31.25116219
43TAOK31.22815858
44KSR11.22398914
45IRAK11.21298433
46STK241.19532364
47MAP4K21.18456964
48MINK11.17888431
49DYRK21.14722524
50MAP3K51.14086139
51BRD41.11710187
52MAP3K141.09637252
53PLK31.07609467
54CDK191.07389557
55MUSK1.04790383
56TTK1.03722366
57BCR1.01548817
58MAP3K131.00678254
59ADRBK21.00235210
60RIPK40.98765404
61MST40.98183328
62PRPF4B0.94909332
63CHEK20.94133207
64CDC70.94097482
65NLK0.93621244
66PLK20.88166357
67EIF2AK10.87622919
68PRKD20.85187219
69PLK10.84898200
70FER0.84830014
71EPHA40.83038577
72FES0.81363861
73SIK30.80922939
74AKT30.80712728
75PAK60.80691090
76MAP3K20.79671120
77TGFBR10.79113613
78PKN10.77343636
79ATR0.75412320
80GRK70.73896796
81FGR0.73099398
82EIF2AK30.71879333
83BRAF0.69064938
84STK390.68465950
85CDK50.67931102
86WEE10.67537710
87EPHB10.67459170
88TIE10.66561081
89EPHB20.66343279
90CAMK2B0.65030635
91TSSK60.64962150
92SGK20.64668877
93STK30.64116955
94MAP3K40.63735432
95PRKCZ0.62835567
96OXSR10.61690209
97SIK20.61395957
98RPS6KA50.61045650
99ERBB30.60831236
100TEC0.60246342
101CSNK1A1L0.58527502
102GRK10.57829722
103JAK10.57266711
104CSNK1G10.56674950
105NUAK10.55849971
106ATM0.55718781
107JAK20.55115715
108DYRK1A0.50357596
109PRKCG0.49628963
110SGK4940.48617413
111SGK2230.48617413
112CSNK1G30.48254820
113STK380.47609167
114IKBKB0.47413576
115EGFR0.46672296
116AURKB0.45786934
117NTRK20.44368012
118UHMK10.44282069
119AURKA0.43938926
120MAPKAPK50.43857520
121CDK80.43702180
122RPS6KA40.43589795
123MAPK70.43041820
124CDK10.42333829
125CDC42BPA0.41690989
126CHEK10.41650082
127RET0.40836408
128PIK3CG0.40416715
129ABL10.40100746
130DYRK30.40010399
131CAMK2A0.39588421
132LYN0.39054477
133MARK30.38953137
134JAK30.38774331
135NEK90.38235153
136IKBKE0.36695898
137NME10.36191887
138CSK0.35884234
139WNK10.35548869
140CSNK1G20.35547836
141PINK10.34941383
142PRKCE0.34940209
143PDGFRB0.34667881
144SGK10.34538661
145SCYL20.34175484
146FLT30.33680336
147STK110.33039381
148PRKACB0.32159131
149PRKCQ0.31025001
150PRKCI0.30985574
151PRKG10.30613024
152MAP3K70.29810062

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85809311
2Fanconi anemia pathway_Homo sapiens_hsa034602.53627829
3RNA polymerase_Homo sapiens_hsa030202.51886760
4Regulation of autophagy_Homo sapiens_hsa041402.48302039
5Homologous recombination_Homo sapiens_hsa034402.41516145
6Ribosome_Homo sapiens_hsa030102.01337553
7DNA replication_Homo sapiens_hsa030301.95800788
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92955843
9Mismatch repair_Homo sapiens_hsa034301.89085247
10Nicotine addiction_Homo sapiens_hsa050331.79513405
11Basal transcription factors_Homo sapiens_hsa030221.77610923
12Spliceosome_Homo sapiens_hsa030401.76310194
13Non-homologous end-joining_Homo sapiens_hsa034501.71256896
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70728523
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66746906
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60374280
17Phototransduction_Homo sapiens_hsa047441.58488904
18Nucleotide excision repair_Homo sapiens_hsa034201.49692394
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39225670
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38947064
21Cell cycle_Homo sapiens_hsa041101.35195111
22Sphingolipid metabolism_Homo sapiens_hsa006001.33515384
23Dorso-ventral axis formation_Homo sapiens_hsa043201.31239284
24RNA degradation_Homo sapiens_hsa030181.30108955
25Butanoate metabolism_Homo sapiens_hsa006501.28887003
26Propanoate metabolism_Homo sapiens_hsa006401.28138947
27Amphetamine addiction_Homo sapiens_hsa050311.25209089
28Pyrimidine metabolism_Homo sapiens_hsa002401.24652305
29Ether lipid metabolism_Homo sapiens_hsa005651.20953973
30Base excision repair_Homo sapiens_hsa034101.19352270
31Synaptic vesicle cycle_Homo sapiens_hsa047211.18764093
32Long-term potentiation_Homo sapiens_hsa047201.16818809
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16571627
34Proteasome_Homo sapiens_hsa030501.11400103
35Salmonella infection_Homo sapiens_hsa051321.10005134
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07305937
37Serotonergic synapse_Homo sapiens_hsa047261.04554754
38Graft-versus-host disease_Homo sapiens_hsa053321.04110348
39RNA transport_Homo sapiens_hsa030130.98881275
40Purine metabolism_Homo sapiens_hsa002300.98415539
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97924168
42Protein export_Homo sapiens_hsa030600.95903154
43Prolactin signaling pathway_Homo sapiens_hsa049170.95315895
44Glutamatergic synapse_Homo sapiens_hsa047240.94995538
45Osteoclast differentiation_Homo sapiens_hsa043800.93568485
46Morphine addiction_Homo sapiens_hsa050320.93167480
47Allograft rejection_Homo sapiens_hsa053300.92718151
48Cocaine addiction_Homo sapiens_hsa050300.92085574
49Tuberculosis_Homo sapiens_hsa051520.90934202
50Gap junction_Homo sapiens_hsa045400.90703086
51Long-term depression_Homo sapiens_hsa047300.90427398
52Circadian rhythm_Homo sapiens_hsa047100.90326025
53Salivary secretion_Homo sapiens_hsa049700.88790253
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88153467
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.88146144
56Renin secretion_Homo sapiens_hsa049240.88037092
57Autoimmune thyroid disease_Homo sapiens_hsa053200.87849748
58mRNA surveillance pathway_Homo sapiens_hsa030150.87689923
59African trypanosomiasis_Homo sapiens_hsa051430.86162451
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86079002
61Shigellosis_Homo sapiens_hsa051310.83514392
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83433036
63Taste transduction_Homo sapiens_hsa047420.82941377
64Asthma_Homo sapiens_hsa053100.82200800
65Epstein-Barr virus infection_Homo sapiens_hsa051690.82166349
66p53 signaling pathway_Homo sapiens_hsa041150.80324098
67Axon guidance_Homo sapiens_hsa043600.80255965
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78855169
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78806049
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78320067
71Rheumatoid arthritis_Homo sapiens_hsa053230.76659579
72Legionellosis_Homo sapiens_hsa051340.75184805
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74426877
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.74001701
75FoxO signaling pathway_Homo sapiens_hsa040680.70142438
76TNF signaling pathway_Homo sapiens_hsa046680.69974022
77Inositol phosphate metabolism_Homo sapiens_hsa005620.69787657
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68368811
79Measles_Homo sapiens_hsa051620.68292780
80Arachidonic acid metabolism_Homo sapiens_hsa005900.67333487
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67114208
82Hematopoietic cell lineage_Homo sapiens_hsa046400.65780931
83Leishmaniasis_Homo sapiens_hsa051400.65732578
84Herpes simplex infection_Homo sapiens_hsa051680.65368446
85Other glycan degradation_Homo sapiens_hsa005110.64925438
86Huntingtons disease_Homo sapiens_hsa050160.64269732
87Platelet activation_Homo sapiens_hsa046110.64004270
88Oxytocin signaling pathway_Homo sapiens_hsa049210.63564758
89Wnt signaling pathway_Homo sapiens_hsa043100.62963922
90Type II diabetes mellitus_Homo sapiens_hsa049300.62707534
91Circadian entrainment_Homo sapiens_hsa047130.62507940
92GABAergic synapse_Homo sapiens_hsa047270.61810626
93Ras signaling pathway_Homo sapiens_hsa040140.61515693
94Rap1 signaling pathway_Homo sapiens_hsa040150.61311552
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.61253021
96Oxidative phosphorylation_Homo sapiens_hsa001900.59932759
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59579470
98Primary immunodeficiency_Homo sapiens_hsa053400.59345025
99Oocyte meiosis_Homo sapiens_hsa041140.58707476
100Lysosome_Homo sapiens_hsa041420.57922373
101T cell receptor signaling pathway_Homo sapiens_hsa046600.57683006
102Basal cell carcinoma_Homo sapiens_hsa052170.57105535
103Cholinergic synapse_Homo sapiens_hsa047250.55704848
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55465522
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55426210
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.55320635
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55267878
108Chemokine signaling pathway_Homo sapiens_hsa040620.54790581
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54083197
110beta-Alanine metabolism_Homo sapiens_hsa004100.53633012
111Choline metabolism in cancer_Homo sapiens_hsa052310.53562153
112Alcoholism_Homo sapiens_hsa050340.52787915
113MicroRNAs in cancer_Homo sapiens_hsa052060.52383614
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51690110
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51658842
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51405110
117Pancreatic cancer_Homo sapiens_hsa052120.51398916
118Olfactory transduction_Homo sapiens_hsa047400.51095765
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50910446
120cAMP signaling pathway_Homo sapiens_hsa040240.50862993
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50602385
122Toxoplasmosis_Homo sapiens_hsa051450.49195801
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49000343
124Collecting duct acid secretion_Homo sapiens_hsa049660.48972346
125Type I diabetes mellitus_Homo sapiens_hsa049400.48948550
126Melanogenesis_Homo sapiens_hsa049160.48672724
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48164707
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48019619
129Renal cell carcinoma_Homo sapiens_hsa052110.47821383
130Insulin secretion_Homo sapiens_hsa049110.47659387
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46790795
132Melanoma_Homo sapiens_hsa052180.46309714
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46257320
134Prostate cancer_Homo sapiens_hsa052150.46126914
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.46072968
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45512542
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45510221
138Phagosome_Homo sapiens_hsa041450.45462036
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.45267598
140Fatty acid biosynthesis_Homo sapiens_hsa000610.44864798
141Steroid biosynthesis_Homo sapiens_hsa001000.44691982
142Malaria_Homo sapiens_hsa051440.44558683
143Pertussis_Homo sapiens_hsa051330.44547759
144Calcium signaling pathway_Homo sapiens_hsa040200.44532194
145Dopaminergic synapse_Homo sapiens_hsa047280.44155063
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43998392
147Mineral absorption_Homo sapiens_hsa049780.43940450
148Hepatitis C_Homo sapiens_hsa051600.43763481
149mTOR signaling pathway_Homo sapiens_hsa041500.43129330
150Colorectal cancer_Homo sapiens_hsa052100.42974066
151ErbB signaling pathway_Homo sapiens_hsa040120.42567167
152Systemic lupus erythematosus_Homo sapiens_hsa053220.41079761
153MAPK signaling pathway_Homo sapiens_hsa040100.40849230

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