EXOC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.93433058
2positive regulation of gamma-delta T cell activation (GO:0046645)5.51816633
3establishment of integrated proviral latency (GO:0075713)4.79841783
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77894747
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77894747
6positive regulation of T cell cytokine production (GO:0002726)4.60809596
7antigen processing and presentation of endogenous antigen (GO:0019883)4.49332774
8pre-miRNA processing (GO:0031054)4.37655691
9ribosome assembly (GO:0042255)4.36065597
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.21613889
11negative regulation of cell killing (GO:0031342)4.21613889
12regulation of gamma-delta T cell differentiation (GO:0045586)4.20463232
13regulation of T cell chemotaxis (GO:0010819)4.14775995
14positive regulation of T cell chemotaxis (GO:0010820)4.14775995
15negative T cell selection (GO:0043383)4.06182446
16negative thymic T cell selection (GO:0045060)4.01329991
17negative regulation of fibroblast apoptotic process (GO:2000270)3.95236854
18regulation of gamma-delta T cell activation (GO:0046643)3.85261845
19tRNA aminoacylation for protein translation (GO:0006418)3.84728282
20protein localization to kinetochore (GO:0034501)3.75935722
21negative regulation of T cell mediated immunity (GO:0002710)3.75222710
22amino acid activation (GO:0043038)3.74548406
23tRNA aminoacylation (GO:0043039)3.74548406
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73998486
25formation of translation preinitiation complex (GO:0001731)3.73339852
26COPI coating of Golgi vesicle (GO:0048205)3.73144224
27Golgi transport vesicle coating (GO:0048200)3.73144224
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.65536919
29regulation of B cell receptor signaling pathway (GO:0050855)3.61199865
30protein localization to chromosome, centromeric region (GO:0071459)3.56602365
31establishment of viral latency (GO:0019043)3.56593994
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.50912995
33mitotic nuclear envelope disassembly (GO:0007077)3.48588315
34regulation of interleukin-12 biosynthetic process (GO:0045075)3.47818129
35regulation of translational fidelity (GO:0006450)3.42806681
36nuclear envelope disassembly (GO:0051081)3.41578596
37membrane disassembly (GO:0030397)3.41578596
38response to interleukin-15 (GO:0070672)3.41388043
39DNA topological change (GO:0006265)3.40048392
40mitotic spindle checkpoint (GO:0071174)3.37118264
41spindle checkpoint (GO:0031577)3.37064806
42DNA damage response, detection of DNA damage (GO:0042769)3.36558204
43mast cell activation (GO:0045576)3.35914394
44positive regulation of B cell differentiation (GO:0045579)3.34334533
45regulation of fibroblast apoptotic process (GO:2000269)3.34232743
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.33669243
47negative regulation of chromosome segregation (GO:0051985)3.32396532
48non-recombinational repair (GO:0000726)3.31926163
49double-strand break repair via nonhomologous end joining (GO:0006303)3.31926163
50T cell migration (GO:0072678)3.29561215
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29068685
52negative regulation of mitotic sister chromatid separation (GO:2000816)3.29068685
53negative regulation of sister chromatid segregation (GO:0033046)3.29068685
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29068685
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.29068685
56mast cell activation involved in immune response (GO:0002279)3.26908647
57mast cell degranulation (GO:0043303)3.26908647
58mitotic sister chromatid segregation (GO:0000070)3.25882261
59positive regulation of transforming growth factor beta production (GO:0071636)3.25638284
60cellular extravasation (GO:0045123)3.25011443
61DNA double-strand break processing (GO:0000729)3.24613986
62leukocyte aggregation (GO:0070486)3.20821474
63mitotic spindle assembly checkpoint (GO:0007094)3.20680072
64mitotic metaphase plate congression (GO:0007080)3.19697415
65interferon-gamma production (GO:0032609)3.18538769
66definitive hemopoiesis (GO:0060216)3.16831324
67spindle assembly checkpoint (GO:0071173)3.15426171
68positive thymic T cell selection (GO:0045059)3.14306645
69sister chromatid segregation (GO:0000819)3.13576816
70regulation of sister chromatid segregation (GO:0033045)3.12796109
71regulation of mitotic sister chromatid separation (GO:0010965)3.12796109
72regulation of mitotic sister chromatid segregation (GO:0033047)3.12796109
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12443233
74regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12443233
75regulation of chromosome segregation (GO:0051983)3.10341398
76activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.06531041
77NIK/NF-kappaB signaling (GO:0038061)3.05994419
78B cell receptor signaling pathway (GO:0050853)3.04115997
79positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03175446
80folic acid-containing compound biosynthetic process (GO:0009396)3.02749773
81DNA duplex unwinding (GO:0032508)3.01024376
82myeloid dendritic cell activation (GO:0001773)3.00264879
83regulation of helicase activity (GO:0051095)2.99424479
84T cell selection (GO:0045058)2.98675828
85L-serine metabolic process (GO:0006563)2.98003381
86lactate metabolic process (GO:0006089)2.97587614
87DNA geometric change (GO:0032392)2.96770452
88positive regulation of chromosome segregation (GO:0051984)2.95665518
89intra-S DNA damage checkpoint (GO:0031573)2.95536537
90positive T cell selection (GO:0043368)2.95007577
91negative regulation of phagocytosis (GO:0050765)2.93943299
92regulation of B cell differentiation (GO:0045577)2.93647917
93thymic T cell selection (GO:0045061)2.91957202
94IMP biosynthetic process (GO:0006188)2.90534160
95megakaryocyte development (GO:0035855)2.90483586
96antigen processing and presentation via MHC class Ib (GO:0002475)2.87280649
97histone H2A acetylation (GO:0043968)2.87030191
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85304156
99germinal center formation (GO:0002467)2.85068374
100proteasome assembly (GO:0043248)2.84779466
101RNA-dependent DNA replication (GO:0006278)2.84668816
102neutrophil activation involved in immune response (GO:0002283)2.83344139
103peptidyl-arginine omega-N-methylation (GO:0035247)2.82776866
104cellular response to interleukin-15 (GO:0071350)2.82508053
105B cell homeostasis (GO:0001782)2.82207937
106protein complex localization (GO:0031503)2.81873498
107establishment of chromosome localization (GO:0051303)2.81866214
108nuclear pore complex assembly (GO:0051292)2.81208945
109synapsis (GO:0007129)2.80772297
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.80454354
1117-methylguanosine mRNA capping (GO:0006370)2.78934257
112regulation of protein glycosylation (GO:0060049)2.78909907
113regulation of transforming growth factor beta production (GO:0071634)2.78449392
114T cell homeostasis (GO:0043029)2.78113889
115mitotic chromosome condensation (GO:0007076)2.77857871
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77339913
117regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76353840
118gene silencing by RNA (GO:0031047)2.75644883
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75157381
120T cell proliferation (GO:0042098)2.74560636
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74290086
122telomere maintenance via telomerase (GO:0007004)2.74242438
123hepatocyte apoptotic process (GO:0097284)2.73897719
124metaphase plate congression (GO:0051310)2.71825036
125nuclear envelope organization (GO:0006998)2.71170169
126regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70757794
127regulation of mitotic spindle checkpoint (GO:1903504)2.70757794
1287-methylguanosine RNA capping (GO:0009452)2.68812886
129RNA capping (GO:0036260)2.68812886
130leukocyte degranulation (GO:0043299)2.68797881
131myeloid dendritic cell differentiation (GO:0043011)2.68151162
132protein localization to chromosome (GO:0034502)2.65608961
133negative regulation of DNA recombination (GO:0045910)2.65012260
134cellular response to interleukin-4 (GO:0071353)2.63932417
135regulation of sister chromatid cohesion (GO:0007063)2.63830934
136regulation of isotype switching to IgG isotypes (GO:0048302)2.63391206
137metallo-sulfur cluster assembly (GO:0031163)2.63288438
138iron-sulfur cluster assembly (GO:0016226)2.63288438
139histone arginine methylation (GO:0034969)2.62259034
140IMP metabolic process (GO:0046040)2.62132495
141lymphocyte homeostasis (GO:0002260)2.61653630
142chromosome segregation (GO:0007059)2.61172285
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60248468
144negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.60029966
145regulation of interferon-beta biosynthetic process (GO:0045357)2.58222365
146positive regulation of interleukin-2 production (GO:0032743)2.57445641
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57389488
148myeloid cell activation involved in immune response (GO:0002275)2.55833782
149mitotic sister chromatid cohesion (GO:0007064)2.55192853
150interferon-gamma-mediated signaling pathway (GO:0060333)2.52296821
151T cell costimulation (GO:0031295)2.51943716
152leukocyte cell-cell adhesion (GO:0007159)2.51644699
153tolerance induction (GO:0002507)2.50286910
154lymphocyte costimulation (GO:0031294)2.49943972
155regulation of alpha-beta T cell proliferation (GO:0046640)2.49625642
156positive regulation of natural killer cell differentiation (GO:0032825)2.48219447
157respiratory burst (GO:0045730)2.47623116
158JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47544303
159antigen receptor-mediated signaling pathway (GO:0050851)2.46478788
160regulation of T cell receptor signaling pathway (GO:0050856)2.43379168
161lymphocyte proliferation (GO:0046651)2.43305659
162CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41206357
163positive regulation of granulocyte differentiation (GO:0030854)2.41159580
164mononuclear cell proliferation (GO:0032943)2.40553539
165positive regulation of erythrocyte differentiation (GO:0045648)2.40004457
166regulation of defense response to virus by virus (GO:0050690)2.39548244
167T cell receptor signaling pathway (GO:0050852)2.38384399
168neutrophil activation (GO:0042119)2.37574826
169regulation of regulatory T cell differentiation (GO:0045589)2.37286585
170natural killer cell differentiation (GO:0001779)2.35909347
171pore complex assembly (GO:0046931)2.35183891
172regulation of erythrocyte differentiation (GO:0045646)2.34997565
173germ cell migration (GO:0008354)2.34421969
174negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.32970575
175negative regulation of B cell proliferation (GO:0030889)2.32232553
176nuclear pore organization (GO:0006999)2.31163715
177leukocyte homeostasis (GO:0001776)2.30737218
178regulation of interleukin-2 biosynthetic process (GO:0045076)2.30474115
179response to protozoan (GO:0001562)2.29671999
180natural killer cell activation (GO:0030101)2.29669096
181defense response to protozoan (GO:0042832)2.29500671
182positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29451201
183leukocyte proliferation (GO:0070661)2.29051469
184activated T cell proliferation (GO:0050798)2.28955768
185necroptotic process (GO:0070266)2.28944620
186dendritic cell chemotaxis (GO:0002407)2.27898233
187pinocytosis (GO:0006907)2.24815325
188B cell proliferation (GO:0042100)2.24744334
189cellular response to zinc ion (GO:0071294)2.22698699
190embryonic hemopoiesis (GO:0035162)2.22301522
191dendritic cell differentiation (GO:0097028)2.22268868
192regulation of DNA endoreduplication (GO:0032875)2.21560980
193granulocyte activation (GO:0036230)2.21394662
194modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18554406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48541089
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.25250655
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.82343673
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.10787635
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.92850412
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.50830318
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.50769613
8* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.35112117
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16031131
10MYC_22102868_ChIP-Seq_BL_Human3.07403415
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.02117986
12SCL_19346495_ChIP-Seq_HPC-7_Human2.84890181
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.82507754
14RUNX_20019798_ChIP-Seq_JUKART_Human2.80675636
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79904688
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.64914903
17* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60935787
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.60753108
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59863328
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59728413
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51394325
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.47185403
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.45892598
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.43278552
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.40164074
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.39888192
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39877821
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38652597
29* MYB_26560356_Chip-Seq_TH2_Human2.38509882
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36136642
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32058111
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27102820
33BP1_19119308_ChIP-ChIP_Hs578T_Human2.26583998
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24480268
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19893530
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17686812
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16070537
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13633239
39PADI4_21655091_ChIP-ChIP_MCF-7_Human2.12782445
40MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07353360
41ETS1_20019798_ChIP-Seq_JURKAT_Human2.06910625
42VDR_23849224_ChIP-Seq_CD4+_Human2.05124308
43VDR_21846776_ChIP-Seq_THP-1_Human2.04447516
44MAF_26560356_Chip-Seq_TH1_Human2.02508545
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02190079
46* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98388061
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97743568
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95745702
49GATA1_22025678_ChIP-Seq_K562_Human1.94102342
50FOXP3_21729870_ChIP-Seq_TREG_Human1.91966474
51MYB_26560356_Chip-Seq_TH1_Human1.91178068
52SPI1_23547873_ChIP-Seq_NB4_Human1.90362150
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90276657
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87891224
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87285844
56TCF7_22412390_ChIP-Seq_EML_Mouse1.86822125
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.86487386
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85662080
59* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84250193
60SPI1_23127762_ChIP-Seq_K562_Human1.83924503
61UTX_26944678_Chip-Seq_JUKART_Human1.83612284
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82598875
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82564242
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79342958
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77399899
66* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75910395
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75749828
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74729413
69DCP1A_22483619_ChIP-Seq_HELA_Human1.74629323
70VDR_24763502_ChIP-Seq_THP-1_Human1.73918802
71* RUNX1_22412390_ChIP-Seq_EML_Mouse1.72535552
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72071870
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61484926
74TAF15_26573619_Chip-Seq_HEK293_Human1.60523955
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59984303
76FUS_26573619_Chip-Seq_HEK293_Human1.59256405
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53375606
78GATA3_27048872_Chip-Seq_THYMUS_Human1.51522567
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49852255
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49796661
81* GABP_19822575_ChIP-Seq_HepG2_Human1.45774394
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44499343
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43694260
84EWS_26573619_Chip-Seq_HEK293_Human1.43433402
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.41707106
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41194131
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40801448
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40066767
89* PU_27001747_Chip-Seq_BMDM_Mouse1.39217639
90AR_21909140_ChIP-Seq_LNCAP_Human1.37856446
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37480122
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35181465
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34872889
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34176848
95* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33623048
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33569119
97KDM2B_26808549_Chip-Seq_DND41_Human1.33135060
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29503521
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.27681993
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26003482
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25829578
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25718772
103* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24412912
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24305470
105IGF1R_20145208_ChIP-Seq_DFB_Human1.23651172
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23523559
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23063389
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22006870
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21970594
110GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21422865
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20856303
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18648542
113SOX17_20123909_ChIP-Seq_XEN_Mouse1.17659742
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17274727
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13537401
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12969179
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.12209597
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11819733
119KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09818011
120ELK1_19687146_ChIP-ChIP_HELA_Human1.09815924
121GATA3_26560356_Chip-Seq_TH2_Human1.09674972
122TTF2_22483619_ChIP-Seq_HELA_Human1.09185639
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08670186
124KDM5A_27292631_Chip-Seq_BREAST_Human1.07989834
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07360872
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06663720
127E2F1_21310950_ChIP-Seq_MCF-7_Human1.06589969
128SALL1_21062744_ChIP-ChIP_HESCs_Human1.06309595
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06188738
130SRF_21415370_ChIP-Seq_HL-1_Mouse1.05580230
131VDR_24787735_ChIP-Seq_THP-1_Human0.97938961
132ZNF274_21170338_ChIP-Seq_K562_Hela0.97787945
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97757920
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.97396163
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97029480
136* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96923363
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.96865557
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96715994
139XRN2_22483619_ChIP-Seq_HELA_Human0.96712368
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96400815
141CIITA_25753668_ChIP-Seq_RAJI_Human0.95287687
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95140094
143LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94983860
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94642900
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93721839
146MAF_26560356_Chip-Seq_TH2_Human0.92694665
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.92249046
148* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92024110
149EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91187968
150MYC_18940864_ChIP-ChIP_HL60_Human0.90751434
151SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90682984
152DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90484916
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90083800
154FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88024715
155ELK3_25401928_ChIP-Seq_HUVEC_Human0.87566436
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.87154525
157SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85948674
158NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85887739
159YY1_21170310_ChIP-Seq_MESCs_Mouse0.85497636
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85207351
161NOTCH1_21737748_ChIP-Seq_TLL_Human0.84658602
162CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84415866
163BRD4_25478319_ChIP-Seq_HGPS_Human0.83836641
164SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83317331
165* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82860985
166ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79586988
167TFEB_21752829_ChIP-Seq_HELA_Human0.78553551
168PKCTHETA_26484144_Chip-Seq_BREAST_Human0.78506291
169FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78403435
170WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76306170
171TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.75032862
172TP53_16413492_ChIP-PET_HCT116_Human0.74229338
173GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72968178
174SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72707316
175GATA2_19941826_ChIP-Seq_K562_Human0.71715633
176GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71468302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.05460325
2MP0001835_abnormal_antigen_presentation3.41779544
3MP0004957_abnormal_blastocyst_morpholog3.35599980
4MP0000569_abnormal_digit_pigmentation3.28613626
5MP0002396_abnormal_hematopoietic_system3.11168633
6MP0004808_abnormal_hematopoietic_stem2.87334446
7MP0005671_abnormal_response_to2.85997525
8MP0003693_abnormal_embryo_hatching2.82176003
9MP0003763_abnormal_thymus_physiology2.64873432
10MP0003436_decreased_susceptibility_to2.62632979
11MP0003941_abnormal_skin_development2.55866479
12MP0000685_abnormal_immune_system2.51711815
13MP0010352_gastrointestinal_tract_polyps2.45534040
14MP0001800_abnormal_humoral_immune2.42554774
15MP0005000_abnormal_immune_tolerance2.39131159
16MP0008932_abnormal_embryonic_tissue2.37025375
17MP0002166_altered_tumor_susceptibility2.34804314
18MP0002398_abnormal_bone_marrow2.28894592
19MP0002452_abnormal_antigen_presenting2.26157615
20MP0009785_altered_susceptibility_to2.24268509
21MP0009697_abnormal_copulation2.24125233
22MP0002420_abnormal_adaptive_immunity2.22682760
23MP0006054_spinal_hemorrhage2.21342150
24MP0003221_abnormal_cardiomyocyte_apopto2.20663059
25MP0003303_peritoneal_inflammation2.19851079
26MP0001819_abnormal_immune_cell2.19690794
27MP0003786_premature_aging2.18962178
28MP0001730_embryonic_growth_arrest2.15275895
29MP0001661_extended_life_span2.08939612
30MP0002723_abnormal_immune_serum2.06539103
31MP0005387_immune_system_phenotype2.02730727
32MP0001790_abnormal_immune_system2.02730727
33MP0002006_tumorigenesis1.99412901
34MP0002419_abnormal_innate_immunity1.93469062
35MP0005025_abnormal_response_to1.93334450
36MP0000703_abnormal_thymus_morphology1.92638108
37MP0005464_abnormal_platelet_physiology1.90494854
38MP0009672_abnormal_birth_weight1.89327996
39MP0000716_abnormal_immune_system1.88845799
40MP0000372_irregular_coat_pigmentation1.85628195
41MP0002877_abnormal_melanocyte_morpholog1.79705842
42MP0004272_abnormal_basement_membrane1.79200375
43MP0003300_gastrointestinal_ulcer1.77094579
44MP0005397_hematopoietic_system_phenotyp1.76161573
45MP0001545_abnormal_hematopoietic_system1.76161573
46MP0010307_abnormal_tumor_latency1.75216664
47MP0003718_maternal_effect1.73034910
48MP0003890_abnormal_embryonic-extraembry1.71849653
49MP0002722_abnormal_immune_system1.70660886
50MP0006082_CNS_inflammation1.70388221
51MP0002148_abnormal_hypersensitivity_rea1.68010661
52MP0004233_abnormal_muscle_weight1.65682156
53MP0001293_anophthalmia1.65592157
54MP0002429_abnormal_blood_cell1.61767926
55MP0001672_abnormal_embryogenesis/_devel1.59553959
56MP0005380_embryogenesis_phenotype1.59553959
57MP0000689_abnormal_spleen_morphology1.59319394
58MP0002405_respiratory_system_inflammati1.54814626
59MP0003724_increased_susceptibility_to1.54013759
60MP0009278_abnormal_bone_marrow1.53327693
61MP0010234_abnormal_vibrissa_follicle1.52988527
62MP0005174_abnormal_tail_pigmentation1.46960350
63MP0004197_abnormal_fetal_growth/weight/1.45018845
64MP0009333_abnormal_splenocyte_physiolog1.44563401
65MP0002084_abnormal_developmental_patter1.43339924
66MP0004947_skin_inflammation1.42171126
67MP0003183_abnormal_peptide_metabolism1.42167095
68MP0010155_abnormal_intestine_physiology1.41969007
69MP0001697_abnormal_embryo_size1.40535375
70MP0002080_prenatal_lethality1.40412171
71MP0004510_myositis1.39649451
72MP0008007_abnormal_cellular_replicative1.38780687
73MP0003984_embryonic_growth_retardation1.38632548
74MP0010094_abnormal_chromosome_stability1.38231077
75MP0005076_abnormal_cell_differentiation1.35655114
76MP0001533_abnormal_skeleton_physiology1.35439196
77MP0002088_abnormal_embryonic_growth/wei1.34952389
78MP0003091_abnormal_cell_migration1.34825619
79MP0001299_abnormal_eye_distance/1.34630170
80MP0001873_stomach_inflammation1.34242863
81MP0002254_reproductive_system_inflammat1.33054818
82MP0006035_abnormal_mitochondrial_morpho1.31676898
83MP0008057_abnormal_DNA_replication1.30726888
84MP0001348_abnormal_lacrimal_gland1.27262106
85MP0000465_gastrointestinal_hemorrhage1.26886277
86MP0000647_abnormal_sebaceous_gland1.25941291
87MP0002085_abnormal_embryonic_tissue1.25385586
88MP0009703_decreased_birth_body1.23974645
89MP0005408_hypopigmentation1.23723793
90MP0001845_abnormal_inflammatory_respons1.22729111
91MP0003943_abnormal_hepatobiliary_system1.22161987
92MP0005075_abnormal_melanosome_morpholog1.22055582
93MP0002086_abnormal_extraembryonic_tissu1.19984029
94MP0002009_preneoplasia1.19204680
95MP0000490_abnormal_crypts_of1.15674026
96MP0003448_altered_tumor_morphology1.15219341
97MP0002102_abnormal_ear_morphology1.14937669
98MP0003787_abnormal_imprinting1.14445608
99MP0001853_heart_inflammation1.14400793
100MP0003172_abnormal_lysosome_physiology1.13642584
101MP0000358_abnormal_cell_content/1.13301827
102MP0003866_abnormal_defecation1.12915294
103MP0003077_abnormal_cell_cycle1.11809064
104MP0002090_abnormal_vision1.11406886
105MP0005384_cellular_phenotype1.11158738
106MP0005257_abnormal_intraocular_pressure1.10664378
107MP0005310_abnormal_salivary_gland1.00581301
108MP0003567_abnormal_fetal_cardiomyocyte1.00185648
109MP0003705_abnormal_hypodermis_morpholog1.00024024
110MP0000343_altered_response_to0.99984953
111MP0003045_fibrosis0.97300670
112MP0002095_abnormal_skin_pigmentation0.96983893
113MP0002019_abnormal_tumor_incidence0.96544497
114MP0002233_abnormal_nose_morphology0.96536637
115MP0000858_altered_metastatic_potential0.95910899
116MP0000613_abnormal_salivary_gland0.94429471
117MP0002177_abnormal_outer_ear0.91800677
118MP0001984_abnormal_olfaction0.91031442
119MP0004270_analgesia0.89738415
120MP0003279_aneurysm0.89137102
121MP0000371_diluted_coat_color0.88761272
122MP0003828_pulmonary_edema0.87391038
123MP0002998_abnormal_bone_remodeling0.86753155
124MP0002697_abnormal_eye_size0.86648581
125MP0009780_abnormal_chondrocyte_physiolo0.85234806
126MP0003566_abnormal_cell_adhesion0.85099668
127MP0002933_joint_inflammation0.84903981
128MP0003385_abnormal_body_wall0.84882287
129MP0001286_abnormal_eye_development0.84757549
130MP0000015_abnormal_ear_pigmentation0.83867127
131MP0002092_abnormal_eye_morphology0.83144292
132MP0005451_abnormal_body_composition0.82827812
133MP0005623_abnormal_meninges_morphology0.82519190
134MP0005394_taste/olfaction_phenotype0.81657282
135MP0005499_abnormal_olfactory_system0.81657282
136MP0008770_decreased_survivor_rate0.80452863
137MP0004859_abnormal_synaptic_plasticity0.78684607
138MP0003123_paternal_imprinting0.78438411
139MP0003111_abnormal_nucleus_morphology0.77761597
140MP0003136_yellow_coat_color0.76957936
141MP0001915_intracranial_hemorrhage0.76403424
142MP0003937_abnormal_limbs/digits/tail_de0.75587690
143MP0005248_abnormal_Harderian_gland0.74550758
144MP0002163_abnormal_gland_morphology0.73787432
145MP0008260_abnormal_autophagy0.73701931
146MP0003121_genomic_imprinting0.72282990
147MP0010678_abnormal_skin_adnexa0.71802259
148MP0001727_abnormal_embryo_implantation0.71163866
149MP0001346_abnormal_lacrimal_gland0.71161604
150MP0003861_abnormal_nervous_system0.71006868
151MP0000013_abnormal_adipose_tissue0.69626730
152MP0005023_abnormal_wound_healing0.69199908
153MP0000428_abnormal_craniofacial_morphol0.69090736
154MP0005391_vision/eye_phenotype0.69021192
155MP0005621_abnormal_cell_physiology0.68895821
156MP0000350_abnormal_cell_proliferation0.68735266
157MP0000778_abnormal_nervous_system0.68601739
158MP0000313_abnormal_cell_death0.68458794
159MP0001177_atelectasis0.67843958
160MP0002210_abnormal_sex_determination0.67654927
161MP0008789_abnormal_olfactory_epithelium0.67573210
162MP0005395_other_phenotype0.66905447
163MP0001879_abnormal_lymphatic_vessel0.63848805
164MP0000733_abnormal_muscle_development0.61624901
165MP0001851_eye_inflammation0.60954841
166MP0005390_skeleton_phenotype0.59505254
167MP0003075_altered_response_to0.59363649
168MP0003795_abnormal_bone_structure0.58868889
169MP0008058_abnormal_DNA_repair0.57014204
170MP0004811_abnormal_neuron_physiology0.54920058
171MP0000604_amyloidosis0.53837149
172MP0008961_abnormal_basal_metabolism0.52852006
173MP0002925_abnormal_cardiovascular_devel0.52508237

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.53328799
2Cortical dysplasia (HP:0002539)4.33263305
3Papillary thyroid carcinoma (HP:0002895)3.81994658
4Myositis (HP:0100614)3.80825527
5Elevated erythrocyte sedimentation rate (HP:0003565)3.60316903
6Spontaneous hematomas (HP:0007420)3.45435803
7T lymphocytopenia (HP:0005403)3.44801679
8Abnormality of T cell number (HP:0011839)3.32727912
9Orchitis (HP:0100796)3.32300880
10Thrombocytosis (HP:0001894)3.29237660
11Retinal dysplasia (HP:0007973)3.28445361
12Eczematoid dermatitis (HP:0000976)3.26163879
13Recurrent viral infections (HP:0004429)3.25491085
14Cellulitis (HP:0100658)3.23459431
15Recurrent fungal infections (HP:0002841)3.22350066
16Termporal pattern (HP:0011008)3.16482269
17Insidious onset (HP:0003587)3.16482269
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.13403840
19Short 4th metacarpal (HP:0010044)3.13403840
20Nephroblastoma (Wilms tumor) (HP:0002667)3.12494636
21Embryonal renal neoplasm (HP:0011794)3.12233453
22Recurrent bronchitis (HP:0002837)3.08509019
23Retrobulbar optic neuritis (HP:0100654)3.04548679
24Optic neuritis (HP:0100653)3.04548679
25Recurrent abscess formation (HP:0002722)3.01960050
26Thyroid carcinoma (HP:0002890)2.95017148
27Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.92124900
28Abnormality of T cells (HP:0002843)2.85923582
29Cutaneous melanoma (HP:0012056)2.80837563
30Recurrent cutaneous fungal infections (HP:0011370)2.78365645
31Chronic mucocutaneous candidiasis (HP:0002728)2.78365645
32IgM deficiency (HP:0002850)2.77005308
33Prominent metopic ridge (HP:0005487)2.74086397
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.73099447
35Recurrent bacterial skin infections (HP:0005406)2.69057999
36Abnormal hair whorl (HP:0010721)2.67376708
37Prominent nose (HP:0000448)2.67179924
38Neoplasm of the oral cavity (HP:0100649)2.64174491
39Chronic otitis media (HP:0000389)2.63849935
40Meningitis (HP:0001287)2.56729537
41Arterial thrombosis (HP:0004420)2.55738426
42Heterotopia (HP:0002282)2.54408083
43Increased cerebral lipofuscin (HP:0011813)2.51727837
44Abnormality of the metopic suture (HP:0005556)2.51726714
45Abnormal auditory evoked potentials (HP:0006958)2.50169104
46Microvesicular hepatic steatosis (HP:0001414)2.49408682
47Chest pain (HP:0100749)2.43100136
48Thyroiditis (HP:0100646)2.42913642
49Upper limb muscle weakness (HP:0003484)2.42428442
50Hematochezia (HP:0002573)2.41765916
51Subacute progressive viral hepatitis (HP:0006572)2.41275880
52Cerebral hypomyelination (HP:0006808)2.40959175
53Chromsome breakage (HP:0040012)2.39850601
54Vasculitis (HP:0002633)2.39849634
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.39341289
56Syringomyelia (HP:0003396)2.37137319
57Spinal cord lesions (HP:0100561)2.37137319
58Spastic diplegia (HP:0001264)2.36885136
59Lymphopenia (HP:0001888)2.36873678
60Ependymoma (HP:0002888)2.36775755
61Disinhibition (HP:0000734)2.35835520
62Type II lissencephaly (HP:0007260)2.35443771
63Volvulus (HP:0002580)2.33995837
64Mediastinal lymphadenopathy (HP:0100721)2.33522637
65Intestinal atresia (HP:0011100)2.32963029
66Abnormal lung lobation (HP:0002101)2.32747558
67Complete atrioventricular canal defect (HP:0001674)2.31915591
68Menstrual irregularities (HP:0000858)2.30861102
69Acute myeloid leukemia (HP:0004808)2.30649595
70Panhypogammaglobulinemia (HP:0003139)2.30069212
71Agnosia (HP:0010524)2.29190337
72Abnormality of T cell physiology (HP:0011840)2.29189136
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.28253837
74Abnormality of the antihelix (HP:0009738)2.28229524
75Shoulder girdle muscle weakness (HP:0003547)2.27010357
76Agammaglobulinemia (HP:0004432)2.25921963
77Hepatoblastoma (HP:0002884)2.24898944
78Progressive external ophthalmoplegia (HP:0000590)2.24506904
79Inappropriate behavior (HP:0000719)2.24286215
80Papilledema (HP:0001085)2.23671545
81Gastrointestinal stroma tumor (HP:0100723)2.22961025
82Abnormality of the musculature of the pelvis (HP:0001469)2.22713372
83Abnormality of the hip-girdle musculature (HP:0001445)2.22713372
84Large earlobe (HP:0009748)2.22621210
85Interstitial pulmonary disease (HP:0006530)2.21519232
86Horizontal nystagmus (HP:0000666)2.20698879
87Lissencephaly (HP:0001339)2.19814466
88Increased density of long bones (HP:0006392)2.18943905
89B lymphocytopenia (HP:0010976)2.16003923
90Abnormality of B cell number (HP:0010975)2.16003923
91Obstructive lung disease (HP:0006536)2.15703266
92Chronic obstructive pulmonary disease (HP:0006510)2.15703266
93Recurrent skin infections (HP:0001581)2.14528023
94Absent frontal sinuses (HP:0002688)2.14505358
95Pulmonary infiltrates (HP:0002113)2.13641297
96Poikiloderma (HP:0001029)2.13072719
97Viral hepatitis (HP:0006562)2.10951329
98Abnormality of the astrocytes (HP:0100707)2.09525926
99Astrocytoma (HP:0009592)2.09525926
100Entropion (HP:0000621)2.09453775
101Freckling (HP:0001480)2.09054945
102Progressive inability to walk (HP:0002505)2.08602580
103Pelvic girdle muscle weakness (HP:0003749)2.07655863
104Basal cell carcinoma (HP:0002671)2.07403015
105Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05028291
106Abnormality of glycolysis (HP:0004366)2.03108699
107Rhabdomyosarcoma (HP:0002859)2.03027183
108Nasal polyposis (HP:0100582)2.02943869
109Keratoconjunctivitis (HP:0001096)2.02552720
110Neoplasm of the adrenal gland (HP:0100631)2.02524661
111Papilloma (HP:0012740)2.02396576
112Verrucae (HP:0200043)2.02396576
113IgG deficiency (HP:0004315)2.01715637
114Peripheral hypomyelination (HP:0007182)2.00490256
115CNS hypomyelination (HP:0003429)2.00219670
116Abnormality of the nasal mucosa (HP:0000433)1.98199055
117Abnormality of the 4th metacarpal (HP:0010012)1.97183884
118Gastrointestinal inflammation (HP:0004386)1.96124615
119Increased serum pyruvate (HP:0003542)1.94946371
120Cystic hygroma (HP:0000476)1.93565392
121Leukocytosis (HP:0001974)1.92300715
122Autoimmune thrombocytopenia (HP:0001973)1.91564369
123Increased nuchal translucency (HP:0010880)1.90465270
124Inflammation of the large intestine (HP:0002037)1.90175527
125Osteomyelitis (HP:0002754)1.89775368
126Lymphoma (HP:0002665)1.89150536
127Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88639478
128Glioma (HP:0009733)1.87102736
129Squamous cell carcinoma (HP:0002860)1.86239571
130Fair hair (HP:0002286)1.86118775
131Postnatal microcephaly (HP:0005484)1.85527176
132Amaurosis fugax (HP:0100576)1.85223349
133Medulloblastoma (HP:0002885)1.84621604
134Diminished motivation (HP:0000745)1.84276863
135Keratoconjunctivitis sicca (HP:0001097)1.84055579
136Abnormality of chromosome stability (HP:0003220)1.84052958
137Colon cancer (HP:0003003)1.83547525
138Aplasia cutis congenita (HP:0001057)1.82587430
139Apathy (HP:0000741)1.80792871
140Abnormality of the clitoris (HP:0000056)1.80294673
141Skull defect (HP:0001362)1.80073666
142Petechiae (HP:0000967)1.79976712
143Spastic paraplegia (HP:0001258)1.79132683
144Bicuspid aortic valve (HP:0001647)1.79090483
145Orthostatic hypotension (HP:0001278)1.78932151
146Slow saccadic eye movements (HP:0000514)1.78402426
147Encephalitis (HP:0002383)1.77942103
148IgA deficiency (HP:0002720)1.77927846
149Hypoplasia of the brainstem (HP:0002365)1.77501901
150Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77501901
151Chronic diarrhea (HP:0002028)1.76257398
152Overlapping toe (HP:0001845)1.75702462
153Proximal placement of thumb (HP:0009623)1.75527816
154Pulmonary embolism (HP:0002204)1.75417823
155Vertebral arch anomaly (HP:0008438)1.74496293
156Hypoglycemic seizures (HP:0002173)1.74178064
157Cafe-au-lait spot (HP:0000957)1.74059430
158Transitional cell carcinoma of the bladder (HP:0006740)1.73783734
159Chronic sinusitis (HP:0011109)1.73632475
160Clitoromegaly (HP:0000057)1.73430559
161Asymmetry of the thorax (HP:0001555)1.73422986
162Hypoplasia of the thymus (HP:0000778)1.73052407
163Multiple enchondromatosis (HP:0005701)1.72551770
164Hemoptysis (HP:0002105)1.72264070
165Progressive sensorineural hearing impairment (HP:0000408)1.72015306
166Abnormality of macrophages (HP:0004311)1.71830385
167Deep philtrum (HP:0002002)1.71749519
168Amyotrophic lateral sclerosis (HP:0007354)1.69399976
169Autoamputation (HP:0001218)1.68178623
170Macroorchidism (HP:0000053)1.68158606
171Embryonal neoplasm (HP:0002898)1.67754267
172Sloping forehead (HP:0000340)1.67600433
173Bronchitis (HP:0012387)1.67317010
174Cerebral aneurysm (HP:0004944)1.66155490
175Abnormality of eosinophils (HP:0001879)1.65982323
176Aortic aneurysm (HP:0004942)1.65923872
177Fatigue (HP:0012378)1.65287305
178Eosinophilia (HP:0001880)1.65174778
179Deviation of the thumb (HP:0009603)1.65035231
180Recurrent gram-negative bacterial infections (HP:0005420)1.64953383
181Atrioventricular canal defect (HP:0006695)1.64611208
182Emphysema (HP:0002097)1.63916144
183Bladder carcinoma (HP:0002862)1.63897428
184Bladder neoplasm (HP:0009725)1.63897428
185Decreased lacrimation (HP:0000633)1.63667273
186Sepsis (HP:0100806)1.63630117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK14.16298265
2CDK193.88098276
3NEK93.62327302
4MAP4K13.48291268
5TRIM283.47089794
6NEK13.41884004
7TXK3.26662950
8JAK33.14488141
9BUB13.07987907
10BCR3.03435236
11EEF2K2.93376144
12KIT2.68085980
13MAP3K102.65296139
14TTK2.50263712
15MAP3K142.42683933
16SCYL22.40963653
17TYK22.24380266
18MAP3K132.24340293
19PBK2.23370537
20TGFBR12.13929838
21STK102.03701054
22ZAP702.03689182
23PKN21.98101513
24EIF2AK31.94782509
25ITK1.94694077
26TRIB31.93934667
27EIF2AK11.90738888
28MST41.89394958
29SYK1.89307593
30TEC1.88212264
31EPHA31.78640523
32LRRK21.78368478
33BTK1.71487191
34FGFR31.66349610
35CSF1R1.65105663
36PLK31.62026050
37JAK11.61978300
38MAP3K91.48892708
39PLK41.47058986
40MAP3K41.46571668
41SIK21.46426400
42TNIK1.43026596
43LCK1.40384598
44ERN11.36641709
45HCK1.35702053
46MAP3K121.32699009
47IRAK41.32553950
48FES1.31938084
49CCNB11.27925547
50RIPK41.27646235
51TBK11.27302016
52PIK3CG1.19151541
53PLK11.18059554
54FLT31.15608327
55CDC71.13211868
56GRK61.10688353
57IKBKE1.10399934
58SIK31.09381575
59ERBB31.08168278
60TSSK61.05464789
61DAPK11.05149314
62MARK11.02548223
63CSNK1G11.01098143
64MAP2K70.99772941
65CHEK10.97102517
66ATM0.94621297
67PNCK0.92627953
68PDK20.92611505
69CAMKK20.92309143
70FGFR40.91523062
71ZAK0.91442457
72TGFBR20.91028296
73ALK0.90642979
74CSNK1A1L0.90096169
75CSNK1G30.89952679
76CSNK1G20.88716205
77BRD40.88274368
78PTK60.87153516
79PASK0.85545769
80STK30.85119770
81KSR20.85027701
82PLK20.84932504
83CLK10.80563949
84TTN0.80043963
85RET0.79514564
86LYN0.79070929
87MKNK10.78553713
88BRAF0.78299173
89NEK20.77633089
90AURKB0.77162745
91PIM20.76215113
92CHUK0.75963925
93ATR0.75512123
94PIM10.74241887
95MAP4K20.74223429
96PRKCQ0.73520659
97EIF2AK20.71183324
98JAK20.68880007
99WEE10.67751028
100PDGFRB0.67473053
101ERBB40.66511044
102CAMKK10.66483657
103PRKCH0.63585992
104CSK0.61933650
105FYN0.61408649
106FRK0.60969739
107EGFR0.60434280
108CASK0.60114521
109NEK60.59625690
110RAF10.57568256
111IKBKB0.57267460
112MAP2K30.56111014
113MATK0.55931575
114CDK10.54034151
115NTRK20.53857839
116CDK140.53543172
117CDK60.52016850
118CDK180.51992768
119RPS6KA40.51394157
120CAMK1G0.50488227
121HIPK20.50185266
122STK160.50034735
123STK240.49060988
124LATS10.47196922
125CDK11A0.46658365
126EPHB10.45517106
127KSR10.45303212
128CDK20.45238592
129MINK10.45205177
130DYRK1B0.44225477
131MAP3K80.44045808
132FGFR20.43960269
133CHEK20.43918192
134YES10.43500673
135STK40.43251703
136PDK10.43202587
137FGR0.42321396
138DYRK30.41721959
139MARK30.41216809
140CDK120.41082467
141IGF1R0.40375430
142TIE10.40212469
143WNK30.38837157
144CDK150.38539135
145PRKDC0.38506096
146CSNK1E0.36893414
147MAP3K20.36814825
148CAMK1D0.35158383
149CSNK1D0.34723528
150PAK40.34638580
151NTRK10.34499046
152NLK0.34157111
153CSNK2A20.34149477
154BRSK10.33846449
155RPS6KB10.33677555
156FGFR10.33606679
157RPS6KA50.32975595
158NUAK10.32375470
159TAOK30.30770181
160ILK0.29390062
161SRC0.28765639
162INSR0.26917337
163RPS6KB20.26444084

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.18836892
2Non-homologous end-joining_Homo sapiens_hsa034504.03717914
3Proteasome_Homo sapiens_hsa030503.24654479
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71719952
5Mismatch repair_Homo sapiens_hsa034302.58870670
6RNA transport_Homo sapiens_hsa030132.49901109
7Basal transcription factors_Homo sapiens_hsa030222.30341725
8RNA polymerase_Homo sapiens_hsa030202.28612261
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.23237258
10Primary immunodeficiency_Homo sapiens_hsa053402.13713492
11Spliceosome_Homo sapiens_hsa030402.08189759
12mRNA surveillance pathway_Homo sapiens_hsa030152.02829670
13Leishmaniasis_Homo sapiens_hsa051401.94019025
14Biosynthesis of amino acids_Homo sapiens_hsa012301.85240527
15Nucleotide excision repair_Homo sapiens_hsa034201.83286503
16Pentose phosphate pathway_Homo sapiens_hsa000301.83028776
17Osteoclast differentiation_Homo sapiens_hsa043801.75709711
18Measles_Homo sapiens_hsa051621.74319705
19Steroid biosynthesis_Homo sapiens_hsa001001.71772919
20T cell receptor signaling pathway_Homo sapiens_hsa046601.70746206
21B cell receptor signaling pathway_Homo sapiens_hsa046621.70671405
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69658907
23One carbon pool by folate_Homo sapiens_hsa006701.65965146
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.58690136
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58658725
26Antigen processing and presentation_Homo sapiens_hsa046121.55383564
27Carbon metabolism_Homo sapiens_hsa012001.55373338
28RNA degradation_Homo sapiens_hsa030181.52009893
29Homologous recombination_Homo sapiens_hsa034401.49284932
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48402669
31Chronic myeloid leukemia_Homo sapiens_hsa052201.47163865
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45703137
33Selenocompound metabolism_Homo sapiens_hsa004501.45050407
34Viral myocarditis_Homo sapiens_hsa054161.44485352
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43829943
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43263791
37Toxoplasmosis_Homo sapiens_hsa051451.42541376
38Oocyte meiosis_Homo sapiens_hsa041141.42108911
39Protein export_Homo sapiens_hsa030601.37899447
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.37317954
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35877184
42Hepatitis B_Homo sapiens_hsa051611.34190940
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32547600
44Colorectal cancer_Homo sapiens_hsa052101.30561850
45Fatty acid elongation_Homo sapiens_hsa000621.29793368
46Pancreatic cancer_Homo sapiens_hsa052121.29580331
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29176484
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24463575
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24170358
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23592501
51Acute myeloid leukemia_Homo sapiens_hsa052211.22409424
52Propanoate metabolism_Homo sapiens_hsa006401.22348672
53Platelet activation_Homo sapiens_hsa046111.21952613
54Chemokine signaling pathway_Homo sapiens_hsa040621.21325280
55Legionellosis_Homo sapiens_hsa051341.21145837
56Fanconi anemia pathway_Homo sapiens_hsa034601.21116121
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.20845310
58TNF signaling pathway_Homo sapiens_hsa046681.20401491
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.20344385
60Hematopoietic cell lineage_Homo sapiens_hsa046401.20257877
61Tuberculosis_Homo sapiens_hsa051521.18449009
62Thyroid cancer_Homo sapiens_hsa052161.16710415
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16707241
64Shigellosis_Homo sapiens_hsa051311.15793549
65Non-small cell lung cancer_Homo sapiens_hsa052231.14959357
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.10112811
67Influenza A_Homo sapiens_hsa051641.09123964
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08666988
69Viral carcinogenesis_Homo sapiens_hsa052031.08386755
70Apoptosis_Homo sapiens_hsa042101.08287409
71Adherens junction_Homo sapiens_hsa045201.07461086
72Allograft rejection_Homo sapiens_hsa053301.07223182
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07008453
74NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04726856
75Glioma_Homo sapiens_hsa052141.03542495
76Endometrial cancer_Homo sapiens_hsa052130.99308034
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99129499
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99088535
79mTOR signaling pathway_Homo sapiens_hsa041500.98650975
80Pyrimidine metabolism_Homo sapiens_hsa002400.98248103
81VEGF signaling pathway_Homo sapiens_hsa043700.96375084
82Salmonella infection_Homo sapiens_hsa051320.94919931
83Small cell lung cancer_Homo sapiens_hsa052220.93694969
84Pertussis_Homo sapiens_hsa051330.93227655
85Herpes simplex infection_Homo sapiens_hsa051680.92225765
86HTLV-I infection_Homo sapiens_hsa051660.91824695
87N-Glycan biosynthesis_Homo sapiens_hsa005100.91254175
88Prolactin signaling pathway_Homo sapiens_hsa049170.91253388
89Type I diabetes mellitus_Homo sapiens_hsa049400.90891312
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89782621
91Epstein-Barr virus infection_Homo sapiens_hsa051690.88273611
92Renal cell carcinoma_Homo sapiens_hsa052110.88052179
93Asthma_Homo sapiens_hsa053100.86330404
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.81468134
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80818614
96DNA replication_Homo sapiens_hsa030300.79719491
97Proteoglycans in cancer_Homo sapiens_hsa052050.78043604
98Base excision repair_Homo sapiens_hsa034100.76151014
99MicroRNAs in cancer_Homo sapiens_hsa052060.75666569
100Graft-versus-host disease_Homo sapiens_hsa053320.75239000
101Lysine degradation_Homo sapiens_hsa003100.74866787
102Malaria_Homo sapiens_hsa051440.74507879
103Rheumatoid arthritis_Homo sapiens_hsa053230.74044998
104HIF-1 signaling pathway_Homo sapiens_hsa040660.73389222
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73349104
106ErbB signaling pathway_Homo sapiens_hsa040120.72948156
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72678328
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72220706
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70533575
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70380700
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69887548
112Phagosome_Homo sapiens_hsa041450.69617614
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.69520668
114Hepatitis C_Homo sapiens_hsa051600.67853787
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67037513
116Focal adhesion_Homo sapiens_hsa045100.67015640
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.67006092
118Endocytosis_Homo sapiens_hsa041440.66064212
119Pyruvate metabolism_Homo sapiens_hsa006200.66044286
120Fatty acid metabolism_Homo sapiens_hsa012120.66038315
121Estrogen signaling pathway_Homo sapiens_hsa049150.65702252
122Cell cycle_Homo sapiens_hsa041100.65679772
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64863967
124Type II diabetes mellitus_Homo sapiens_hsa049300.64680268
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63285299
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63160499
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61189744
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60820469
129Hippo signaling pathway_Homo sapiens_hsa043900.60654429
130MAPK signaling pathway_Homo sapiens_hsa040100.60604432
131FoxO signaling pathway_Homo sapiens_hsa040680.60326839
132Long-term potentiation_Homo sapiens_hsa047200.60139414
133Cholinergic synapse_Homo sapiens_hsa047250.59868636
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59809562
135Circadian rhythm_Homo sapiens_hsa047100.59706631
136p53 signaling pathway_Homo sapiens_hsa041150.59309345
137Rap1 signaling pathway_Homo sapiens_hsa040150.58588644
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58559668
139Amoebiasis_Homo sapiens_hsa051460.58023953
140Purine metabolism_Homo sapiens_hsa002300.58002060
141Autoimmune thyroid disease_Homo sapiens_hsa053200.56375315
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55969709
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55333915
144Systemic lupus erythematosus_Homo sapiens_hsa053220.55166120
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54976718
146Olfactory transduction_Homo sapiens_hsa047400.54319681
147Prostate cancer_Homo sapiens_hsa052150.53777396
148Vibrio cholerae infection_Homo sapiens_hsa051100.52465508
149Tight junction_Homo sapiens_hsa045300.52436156
150Inositol phosphate metabolism_Homo sapiens_hsa005620.52413919
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51180836
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51052744
153TGF-beta signaling pathway_Homo sapiens_hsa043500.44082690
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43025094
155Vitamin B6 metabolism_Homo sapiens_hsa007500.42097739
156Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41408471
157Wnt signaling pathway_Homo sapiens_hsa043100.36516633
158Insulin signaling pathway_Homo sapiens_hsa049100.36359177
159Alcoholism_Homo sapiens_hsa050340.34734636
160AMPK signaling pathway_Homo sapiens_hsa041520.34209856

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