EXOC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of superoxide anion generation (GO:0032928)6.29292486
2synaptic vesicle exocytosis (GO:0016079)5.15602446
3developmental pigmentation (GO:0048066)4.89224951
4melanosome organization (GO:0032438)4.86904543
5pigment granule organization (GO:0048753)4.78067764
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77223165
7regulation of early endosome to late endosome transport (GO:2000641)4.73233179
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.71537796
9cellular response to reactive nitrogen species (GO:1902170)4.68237115
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66134856
11vocalization behavior (GO:0071625)4.65080821
12neuron cell-cell adhesion (GO:0007158)4.60860652
13regulation of synaptic vesicle exocytosis (GO:2000300)4.53761280
14melanocyte differentiation (GO:0030318)4.51553794
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51286059
16synaptic vesicle maturation (GO:0016188)4.48080768
17antigen processing and presentation of endogenous antigen (GO:0019883)4.44774771
18pigment cell differentiation (GO:0050931)4.42620177
19positive regulation of receptor recycling (GO:0001921)4.30047988
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.28558281
21glutamate secretion (GO:0014047)4.27539758
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.27237552
23protein localization to synapse (GO:0035418)4.27033266
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22677399
25phenol-containing compound biosynthetic process (GO:0046189)4.21992260
26neuronal action potential propagation (GO:0019227)4.18273773
27stress fiber assembly (GO:0043149)4.18256538
28regulation of glutamate receptor signaling pathway (GO:1900449)4.11035220
29pigment biosynthetic process (GO:0046148)4.10711867
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09852867
31regulation of synaptic vesicle transport (GO:1902803)4.05923028
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.96372880
33regulation of superoxide metabolic process (GO:0090322)3.96179113
34negative regulation of interleukin-1 beta production (GO:0032691)3.94190493
35retinal rod cell development (GO:0046548)3.91933560
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.91213405
37neuron-neuron synaptic transmission (GO:0007270)3.89269049
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89001412
39neurotransmitter secretion (GO:0007269)3.85001084
40regulation of synapse structural plasticity (GO:0051823)3.78244312
41synaptic transmission, glutamatergic (GO:0035249)3.75794076
42NIK/NF-kappaB signaling (GO:0038061)3.70598008
43neuron recognition (GO:0008038)3.69412536
44neurotransmitter-gated ion channel clustering (GO:0072578)3.67022395
45glutamate receptor signaling pathway (GO:0007215)3.65374488
46cellular response to thyroid hormone stimulus (GO:0097067)3.62486528
47response to thyroid hormone (GO:0097066)3.61363134
48response to epinephrine (GO:0071871)3.58545566
49pigment metabolic process (GO:0042440)3.57130912
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.54415959
51calcium-mediated signaling using intracellular calcium source (GO:0035584)3.53764372
52locomotory exploration behavior (GO:0035641)3.53052354
53negative regulation of erythrocyte differentiation (GO:0045647)3.48443369
54regulation of neuronal synaptic plasticity (GO:0048168)3.41433761
55barbed-end actin filament capping (GO:0051016)3.41201498
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41143001
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39829246
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39654301
59exploration behavior (GO:0035640)3.38522661
60presynaptic membrane assembly (GO:0097105)3.36491527
61pinocytosis (GO:0006907)3.33952204
62energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.32643485
63ATP hydrolysis coupled proton transport (GO:0015991)3.32643485
64axonal fasciculation (GO:0007413)3.31356556
65regulation of voltage-gated calcium channel activity (GO:1901385)3.31061985
66presynaptic membrane organization (GO:0097090)3.30499195
67gamma-aminobutyric acid transport (GO:0015812)3.30471663
68protein localization to endosome (GO:0036010)3.29778728
69regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.28664437
70regulation of excitatory postsynaptic membrane potential (GO:0060079)3.27176442
71antigen processing and presentation via MHC class Ib (GO:0002475)3.26452840
72negative regulation of interleukin-1 production (GO:0032692)3.25487908
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.24959634
74response to histamine (GO:0034776)3.24838790
75positive regulation of Cdc42 GTPase activity (GO:0043089)3.24510970
76neurotransmitter transport (GO:0006836)3.24104755
77negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.21772142
78striatum development (GO:0021756)3.20725832
79mannose metabolic process (GO:0006013)3.17287591
80negative regulation of chemokine production (GO:0032682)3.16614373
81negative regulation of necroptotic process (GO:0060546)3.16083053
82positive regulation of membrane potential (GO:0045838)3.15286562
83regulation of integrin-mediated signaling pathway (GO:2001044)3.13879801
84positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13691294
85regulation of postsynaptic membrane potential (GO:0060078)3.12835506
86long-term memory (GO:0007616)3.12650474
87secondary metabolic process (GO:0019748)3.10718641
88behavioral response to cocaine (GO:0048148)3.10008139
89fructose metabolic process (GO:0006000)3.09713192
90regulation of glutamate secretion (GO:0014048)3.09519191
91regulation of vesicle fusion (GO:0031338)3.09285283
92transmission of nerve impulse (GO:0019226)3.08671603
93layer formation in cerebral cortex (GO:0021819)3.07268611
94long-term synaptic potentiation (GO:0060291)3.05804474
95negative regulation of microtubule polymerization (GO:0031115)3.05381446
96regulation of neurotransmitter secretion (GO:0046928)3.02722801
97synaptic vesicle endocytosis (GO:0048488)3.01416012
98regulation of cell communication by electrical coupling (GO:0010649)3.01180985
99cerebellar granule cell differentiation (GO:0021707)2.99874475
100positive regulation of synapse maturation (GO:0090129)2.99657594
101mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98795747
102regulation of necroptotic process (GO:0060544)2.97482752
103negative regulation of neurotransmitter transport (GO:0051589)2.96732673
104proline transport (GO:0015824)2.96179099
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95060536
106membrane depolarization during action potential (GO:0086010)2.94478500
107transferrin transport (GO:0033572)2.94365256
108negative regulation of acute inflammatory response (GO:0002674)2.94118048
109postsynaptic membrane organization (GO:0001941)2.92141847
110regulation of neurotransmitter levels (GO:0001505)2.91793660
111regulation of neurotransmitter transport (GO:0051588)2.91558319
112NADH metabolic process (GO:0006734)2.90710094
113regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.89974557
114regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.89974557
115regulation of dendritic spine morphogenesis (GO:0061001)2.89102504
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.89070749
117regulation of synaptic plasticity (GO:0048167)2.88622360
118chaperone-mediated protein transport (GO:0072321)2.88523274
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.88086905
120establishment of mitochondrion localization (GO:0051654)2.87286533
121positive regulation of potassium ion transmembrane transport (GO:1901381)2.87049192
122dendritic spine morphogenesis (GO:0060997)2.86769393
123membrane hyperpolarization (GO:0060081)2.85598055
124membrane depolarization (GO:0051899)2.85395797
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85148538
126positive regulation of neurotransmitter transport (GO:0051590)2.84458282
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84420012
128adult walking behavior (GO:0007628)2.84316162
129mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82781121
130cell migration in hindbrain (GO:0021535)2.82358744
131positive regulation by symbiont of host defense response (GO:0052509)2.81744075
132modulation by symbiont of host defense response (GO:0052031)2.81744075
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81744075
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81744075
135positive regulation by organism of defense response of other organism involved in symbiotic interact2.81744075
136modulation by symbiont of host immune response (GO:0052553)2.81744075
137regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.81541292
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.81428679
139organelle transport along microtubule (GO:0072384)2.81386042
140detection of calcium ion (GO:0005513)2.80557158
141regulation of synaptic transmission, GABAergic (GO:0032228)2.80431956
142synaptic transmission (GO:0007268)2.79644677
143synapse assembly (GO:0007416)2.79263896
144activation of protein kinase A activity (GO:0034199)2.78593978
145regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78400617
146learning (GO:0007612)2.78209763
147cellular potassium ion homeostasis (GO:0030007)2.77045528
148synaptic transmission, dopaminergic (GO:0001963)2.76049067
149ATP synthesis coupled proton transport (GO:0015986)2.76002836
150cellular response to nitric oxide (GO:0071732)2.75300503
151positive regulation of gamma-delta T cell activation (GO:0046645)2.73398484
152detection of bacterium (GO:0016045)2.69532871
153ketone body metabolic process (GO:1902224)2.68311922
154regulation of receptor recycling (GO:0001919)2.68061177
155pyrimidine nucleoside salvage (GO:0043097)2.67434866
156pyrimidine-containing compound salvage (GO:0008655)2.67434866
157negative regulation of cell killing (GO:0031342)2.67282606
158negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67282606
159antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64654265
160regulation of interferon-beta biosynthetic process (GO:0045357)2.64279743
161gluconeogenesis (GO:0006094)2.64005865
162Golgi transport vesicle coating (GO:0048200)2.63162862
163COPI coating of Golgi vesicle (GO:0048205)2.63162862
164detection of other organism (GO:0098543)2.62206258
165glycosphingolipid catabolic process (GO:0046479)2.60086305
166positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59427562
167regulation of necrotic cell death (GO:0010939)2.53383946
168monosaccharide biosynthetic process (GO:0046364)2.53016248
169hexose biosynthetic process (GO:0019319)2.51845398
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.51764935
171cellular response to epinephrine stimulus (GO:0071872)2.50137895
172phosphatidylinositol dephosphorylation (GO:0046856)2.48840638
173glucose 6-phosphate metabolic process (GO:0051156)2.48488988
174negative regulation of myotube differentiation (GO:0010832)2.48213176
175negative regulation of protein localization to plasma membrane (GO:1903077)2.47103544
176neutrophil activation involved in immune response (GO:0002283)2.46111312
177regulation of clathrin-mediated endocytosis (GO:2000369)2.42913981
178neuroepithelial cell differentiation (GO:0060563)2.42751652
179regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42347272
180hepatocyte apoptotic process (GO:0097284)2.41327242
181positive regulation of antigen processing and presentation (GO:0002579)2.40650940
182positive thymic T cell selection (GO:0045059)2.40216756
183activation of JUN kinase activity (GO:0007257)2.39624075
184negative regulation of organelle assembly (GO:1902116)2.39432153
185response to muramyl dipeptide (GO:0032495)2.38601187
186phospholipid dephosphorylation (GO:0046839)2.38515606
187negative regulation of necrotic cell death (GO:0060547)2.37611476
188positive regulation of reactive oxygen species metabolic process (GO:2000379)2.37385843
189glycolipid catabolic process (GO:0019377)2.36456475
190negative regulation of tumor necrosis factor production (GO:0032720)2.35960260
191macrophage activation involved in immune response (GO:0002281)2.35657622
192glucose catabolic process (GO:0006007)2.34879084
193negative regulation of TOR signaling (GO:0032007)2.34591689
194response to peptidoglycan (GO:0032494)2.34256904
195pentose-phosphate shunt (GO:0006098)2.34095717
196response to parathyroid hormone (GO:0071107)2.32407686
197regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.32392790
198melanin biosynthetic process (GO:0042438)13.3357049
199melanin metabolic process (GO:0006582)12.4681424
200secondary metabolite biosynthetic process (GO:0044550)10.7826603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00848584
2GBX2_23144817_ChIP-Seq_PC3_Human4.20813359
3VDR_21846776_ChIP-Seq_THP-1_Human3.13177971
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09295678
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99376107
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77662250
7MYC_22102868_ChIP-Seq_BL_Human2.51140020
8LXR_22292898_ChIP-Seq_THP-1_Human2.49619854
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48961998
10REST_21632747_ChIP-Seq_MESCs_Mouse2.46207148
11TAF15_26573619_Chip-Seq_HEK293_Human2.45406629
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40512080
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40512080
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38734018
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37798590
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.37498297
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36865163
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29483834
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29391025
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28449789
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24601139
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23243064
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21557924
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.21457471
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.18813592
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.16363893
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15956993
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.14797102
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14249063
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13508138
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11795799
32AR_21572438_ChIP-Seq_LNCaP_Human2.10528596
33* VDR_24763502_ChIP-Seq_THP-1_Human2.10410441
34RACK7_27058665_Chip-Seq_MCF-7_Human2.09143896
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07650302
36DROSHA_22980978_ChIP-Seq_HELA_Human2.00423766
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99089688
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.98655927
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97579794
40TCF7_22412390_ChIP-Seq_EML_Mouse1.96003814
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95833173
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.94496317
43IGF1R_20145208_ChIP-Seq_DFB_Human1.90026970
44ZNF274_21170338_ChIP-Seq_K562_Hela1.89902755
45SMAD4_21799915_ChIP-Seq_A2780_Human1.86567013
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.86097581
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81573156
48KDM2B_26808549_Chip-Seq_DND41_Human1.81331882
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81205790
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80582942
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79972209
52* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79890562
53P300_19829295_ChIP-Seq_ESCs_Human1.79207219
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77303923
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76575632
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75608193
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75533849
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74501024
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68659664
60TFEB_21752829_ChIP-Seq_HELA_Human1.66094040
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65603216
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65570842
63MAF_26560356_Chip-Seq_TH1_Human1.64175938
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64021988
65* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63620645
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62872851
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.62182041
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60906434
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59783704
70* SMC4_20622854_ChIP-Seq_HELA_Human1.58784185
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58673944
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.55791423
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54083954
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53501862
75UTX_26944678_Chip-Seq_JUKART_Human1.52882810
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49087883
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48087924
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.47592642
79FUS_26573619_Chip-Seq_HEK293_Human1.47401885
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46618788
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45520499
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44875413
83ER_23166858_ChIP-Seq_MCF-7_Human1.44038505
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43971442
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.42766142
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.41351968
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39885261
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.39035703
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38616537
90* P68_20966046_ChIP-Seq_HELA_Human1.37978694
91SPI1_23127762_ChIP-Seq_K562_Human1.37580107
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37391713
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37294448
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36784016
95AR_25329375_ChIP-Seq_VCAP_Human1.36110717
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.34747756
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.33567212
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32997817
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32514094
100MAF_26560356_Chip-Seq_TH2_Human1.32419939
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.32317160
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31413273
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30809612
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.29763883
105ZNF263_19887448_ChIP-Seq_K562_Human1.28784425
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28727256
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.27999036
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.27866869
109* BCOR_27268052_Chip-Seq_Bcells_Human1.27401778
110STAT3_23295773_ChIP-Seq_U87_Human1.27282385
111IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26950269
112SCL_19346495_ChIP-Seq_HPC-7_Human1.26820597
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.26496057
114RNF2_27304074_Chip-Seq_NSC_Mouse1.26239301
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25933572
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25281595
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25198560
118SPI1_23547873_ChIP-Seq_NB4_Human1.24555312
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24497715
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24208637
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.24180385
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24151600
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23657624
124RUNX1_27514584_Chip-Seq_MCF-7_Human1.23647268
125CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23281586
126PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21932657
127* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21701274
128FOXM1_23109430_ChIP-Seq_U2OS_Human1.21509963
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21069352
130STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19028858
131TCF4_23295773_ChIP-Seq_U87_Human1.18462711
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18091490
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17948448
134ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17804524
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16981915
136VDR_22108803_ChIP-Seq_LS180_Human1.16880606
137* BCL6_27268052_Chip-Seq_Bcells_Human1.16820838
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15677604
139KDM2B_26808549_Chip-Seq_K562_Human1.15537402
140* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15509162
141GATA1_19941826_ChIP-Seq_K562_Human1.14867776
142CLOCK_20551151_ChIP-Seq_293T_Human1.13855033
143NCOR1_26117541_ChIP-Seq_K562_Human1.13717051
144* AR_19668381_ChIP-Seq_PC3_Human1.13277648
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13171935
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12953672
147ARNT_22903824_ChIP-Seq_MCF-7_Human1.12156876
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11710122
149GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10821477
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10511206
151GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10464176
152EGR1_19374776_ChIP-ChIP_THP-1_Human1.09467986
153ESR1_20079471_ChIP-ChIP_T-47D_Human1.09370778
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09355468
155TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08761012
156NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08447893
157MITF_21258399_ChIP-Seq_MELANOMA_Human1.07747407
158CIITA_25753668_ChIP-Seq_RAJI_Human1.07294312
159PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06900870
160FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06713175
161ERG_21242973_ChIP-ChIP_JURKAT_Human1.06433225
162JUN_21703547_ChIP-Seq_K562_Human1.05984933
163GATA6_25053715_ChIP-Seq_YYC3_Human1.05851679
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05631953
165RUNX2_22187159_ChIP-Seq_PCA_Human1.05247030
166E2F7_22180533_ChIP-Seq_HELA_Human1.05165088
167SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04654896
168ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04551749
169VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04085120
170HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03842714
171P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03808205
172ETS1_21867929_ChIP-Seq_TH2_Mouse1.03224795
173ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03174020
174TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02911432
175CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02471700
176MYB_26560356_Chip-Seq_TH1_Human1.02168558
177RXR_22158963_ChIP-Seq_LIVER_Mouse1.02089791
178NANOG_18555785_Chip-Seq_ESCs_Mouse1.01720095
179TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01301123
180MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01208665
181TP53_18474530_ChIP-ChIP_U2OS_Human1.01114264
182NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00962566
183P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00741691
184MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99258630
185RING1B_27294783_Chip-Seq_ESCs_Mouse0.98643705
186YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98333021
187SOX9_26525672_Chip-Seq_HEART_Mouse0.98082003
188AHR_22903824_ChIP-Seq_MCF-7_Human0.97569592
189IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97566478
190CBP_20019798_ChIP-Seq_JUKART_Human0.97566478
191EP300_21415370_ChIP-Seq_HL-1_Mouse0.97253664
192MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93876474
193EWS_26573619_Chip-Seq_HEK293_Human0.91774889
194GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90510175
195CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90159779
196E2F1_18555785_Chip-Seq_ESCs_Mouse0.89521384
197FLI1_21867929_ChIP-Seq_TH2_Mouse0.89498129
198RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88221334
199SMAD4_21741376_ChIP-Seq_EPCs_Human0.87626836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation7.59256938
2MP0004859_abnormal_synaptic_plasticity5.10120905
3MP0003880_abnormal_central_pattern5.06203768
4MP0005408_hypopigmentation4.99041377
5MP0005075_abnormal_melanosome_morpholog4.81093663
6MP0000015_abnormal_ear_pigmentation4.56101963
7MP0002877_abnormal_melanocyte_morpholog4.13527898
8MP0003136_yellow_coat_color3.91839797
9MP0004381_abnormal_hair_follicle3.70952873
10MP0003635_abnormal_synaptic_transmissio3.65077594
11MP0003806_abnormal_nucleotide_metabolis3.57316245
12MP0004270_analgesia3.52235886
13MP0009745_abnormal_behavioral_response3.24843353
14MP0000371_diluted_coat_color3.09058684
15MP0002064_seizures3.07574650
16MP0002063_abnormal_learning/memory/cond3.04328245
17MP0001968_abnormal_touch/_nociception2.91366515
18MP0009046_muscle_twitch2.89720553
19MP0002734_abnormal_mechanical_nocicepti2.72846851
20MP0002095_abnormal_skin_pigmentation2.70812920
21MP0002572_abnormal_emotion/affect_behav2.67504067
22MP0002272_abnormal_nervous_system2.62412516
23MP0002736_abnormal_nociception_after2.56744176
24MP0002735_abnormal_chemical_nociception2.54820120
25MP0003172_abnormal_lysosome_physiology2.51980648
26MP0002837_dystrophic_cardiac_calcinosis2.49604319
27MP0005058_abnormal_lysosome_morphology2.48933062
28MP0001486_abnormal_startle_reflex2.38992060
29MP0002822_catalepsy2.37901986
30MP0010234_abnormal_vibrissa_follicle2.37327813
31MP0005174_abnormal_tail_pigmentation2.30178814
32MP0001529_abnormal_vocalization2.21607169
33MP0005451_abnormal_body_composition2.15362971
34MP0001440_abnormal_grooming_behavior2.11396575
35MP0006276_abnormal_autonomic_nervous2.10290519
36MP0005409_darkened_coat_color2.05146407
37MP0005423_abnormal_somatic_nervous2.02039585
38MP0002067_abnormal_sensory_capabilities2.00918842
39MP0001970_abnormal_pain_threshold1.97805005
40MP0000778_abnormal_nervous_system1.97424910
41MP0001905_abnormal_dopamine_level1.93251756
42MP0000751_myopathy1.91844317
43MP0002733_abnormal_thermal_nociception1.86362193
44MP0003329_amyloid_beta_deposits1.85557099
45MP0001501_abnormal_sleep_pattern1.83937481
46MP0003122_maternal_imprinting1.83512417
47MP0009780_abnormal_chondrocyte_physiolo1.82113281
48MP0001324_abnormal_eye_pigmentation1.81486904
49MP0002075_abnormal_coat/hair_pigmentati1.79718028
50MP0001984_abnormal_olfaction1.75287748
51MP0004924_abnormal_behavior1.73557620
52MP0005386_behavior/neurological_phenoty1.73557620
53MP0002184_abnormal_innervation1.72430558
54MP0008260_abnormal_autophagy1.67806464
55MP0003436_decreased_susceptibility_to1.67118690
56MP0003787_abnormal_imprinting1.64414394
57MP0004811_abnormal_neuron_physiology1.62096142
58MP0002557_abnormal_social/conspecific_i1.60332008
59MP0008569_lethality_at_weaning1.58799554
60MP0004215_abnormal_myocardial_fiber1.54719709
61MP0001186_pigmentation_phenotype1.53458688
62MP0004142_abnormal_muscle_tone1.51565743
63MP0005646_abnormal_pituitary_gland1.51528179
64MP0002909_abnormal_adrenal_gland1.51072030
65MP0003878_abnormal_ear_physiology1.50668265
66MP0005377_hearing/vestibular/ear_phenot1.50668265
67MP0005551_abnormal_eye_electrophysiolog1.43904219
68MP0002882_abnormal_neuron_morphology1.40042148
69MP0002066_abnormal_motor_capabilities/c1.38192927
70MP0005257_abnormal_intraocular_pressure1.37789081
71MP0000955_abnormal_spinal_cord1.35660835
72MP0003303_peritoneal_inflammation1.34291333
73MP0004145_abnormal_muscle_electrophysio1.33474427
74MP0002396_abnormal_hematopoietic_system1.27448801
75MP0009840_abnormal_foam_cell1.23131483
76MP0004036_abnormal_muscle_relaxation1.22991391
77MP0000920_abnormal_myelination1.22754460
78MP0003633_abnormal_nervous_system1.22363900
79MP0000013_abnormal_adipose_tissue1.17666289
80MP0010386_abnormal_urinary_bladder1.16468348
81MP0003300_gastrointestinal_ulcer1.16348855
82MP0002229_neurodegeneration1.15083561
83MP0001835_abnormal_antigen_presentation1.14670537
84MP0003879_abnormal_hair_cell1.14515881
85MP0003763_abnormal_thymus_physiology1.14016216
86MP0004085_abnormal_heartbeat1.10661085
87MP0003631_nervous_system_phenotype1.08882129
88MP0000749_muscle_degeneration1.07133824
89MP0003137_abnormal_impulse_conducting1.06512226
90MP0004484_altered_response_of1.05991273
91MP0004084_abnormal_cardiac_muscle1.05360789
92MP0003183_abnormal_peptide_metabolism1.05257129
93MP0004742_abnormal_vestibular_system1.03465013
94MP0005076_abnormal_cell_differentiation1.03038325
95MP0005248_abnormal_Harderian_gland1.01664527
96MP0003634_abnormal_glial_cell0.99560360
97MP0003866_abnormal_defecation0.99165939
98MP0001188_hyperpigmentation0.99062684
99MP0001502_abnormal_circadian_rhythm0.97827725
100MP0002419_abnormal_innate_immunity0.97658330
101MP0003646_muscle_fatigue0.97554558
102MP0005025_abnormal_response_to0.95690288
103MP0004858_abnormal_nervous_system0.95607675
104MP0000685_abnormal_immune_system0.94238030
105MP0003705_abnormal_hypodermis_morpholog0.93082407
106MP0002152_abnormal_brain_morphology0.92337079
107MP0010155_abnormal_intestine_physiology0.90541057
108MP0003191_abnormal_cellular_cholesterol0.88628773
109MP0002876_abnormal_thyroid_physiology0.88444549
110MP0005464_abnormal_platelet_physiology0.88348264
111MP0005000_abnormal_immune_tolerance0.88084998
112MP0004885_abnormal_endolymph0.87742198
113MP0003690_abnormal_glial_cell0.87103156
114MP0005387_immune_system_phenotype0.87015883
115MP0001790_abnormal_immune_system0.87015883
116MP0006138_congestive_heart_failure0.86942762
117MP0001800_abnormal_humoral_immune0.85644529
118MP0003453_abnormal_keratinocyte_physiol0.85506225
119MP0002069_abnormal_eating/drinking_beha0.85061005
120MP0005171_absent_coat_pigmentation0.84889740
121MP0002090_abnormal_vision0.84534255
122MP0003632_abnormal_nervous_system0.82631486
123MP0001177_atelectasis0.81834937
124MP0002752_abnormal_somatic_nervous0.79554465
125MP0001963_abnormal_hearing_physiology0.79258703
126MP0000569_abnormal_digit_pigmentation0.78723283
127MP0002638_abnormal_pupillary_reflex0.78707557
128MP0002148_abnormal_hypersensitivity_rea0.78520353
129MP0005620_abnormal_muscle_contractility0.78462059
130MP0000604_amyloidosis0.77699294
131MP0002972_abnormal_cardiac_muscle0.77508369
132MP0005535_abnormal_body_temperature0.77058933
133MP0001851_eye_inflammation0.76156515
134MP0002723_abnormal_immune_serum0.75953062
135MP0002420_abnormal_adaptive_immunity0.75840960
136MP0000747_muscle_weakness0.75672772
137MP0005623_abnormal_meninges_morphology0.75555025
138MP0001819_abnormal_immune_cell0.75545014
139MP0004947_skin_inflammation0.75053247
140MP0001849_ear_inflammation0.74437178
141MP0002102_abnormal_ear_morphology0.74306326
142MP0003121_genomic_imprinting0.73816659
143MP0001299_abnormal_eye_distance/0.73497158
144MP0003724_increased_susceptibility_to0.73480069
145MP0002452_abnormal_antigen_presenting0.72868375
146MP0005671_abnormal_response_to0.72496127
147MP0004510_myositis0.72460103
148MP0002166_altered_tumor_susceptibility0.71429128
149MP0004130_abnormal_muscle_cell0.71062616
150MP0009333_abnormal_splenocyte_physiolog0.70676099
151MP0002398_abnormal_bone_marrow0.70199817
152MP0008872_abnormal_physiological_respon0.70048769
153MP0000631_abnormal_neuroendocrine_gland0.69968373
154MP0005253_abnormal_eye_physiology0.69580389
155MP0006072_abnormal_retinal_apoptosis0.68965232
156MP0006035_abnormal_mitochondrial_morpho0.68817045
157MP0002998_abnormal_bone_remodeling0.67591090
158MP0001533_abnormal_skeleton_physiology0.66534021
159MP0005197_abnormal_uvea_morphology0.66462304
160MP0004233_abnormal_muscle_weight0.64032636
161MP0005645_abnormal_hypothalamus_physiol0.62766137
162MP0000367_abnormal_coat/_hair0.62037999
163MP0001943_abnormal_respiration0.60430769
164MP0000716_abnormal_immune_system0.60363722
165MP0001986_abnormal_taste_sensitivity0.59436186
166MP0006036_abnormal_mitochondrial_physio0.58662809
167MP0004808_abnormal_hematopoietic_stem0.58555177
168MP0008874_decreased_physiological_sensi0.58148256
169MP0001845_abnormal_inflammatory_respons0.57410048
170MP0000343_altered_response_to0.56384161
171MP0005584_abnormal_enzyme/coenzyme_acti0.56089216
172MP0005083_abnormal_biliary_tract0.55780351
173MP0002429_abnormal_blood_cell0.55752490
174MP0009115_abnormal_fat_cell0.55310471
175MP0002971_abnormal_brown_adipose0.54659132
176MP0005319_abnormal_enzyme/_coenzyme0.53951500
177MP0001873_stomach_inflammation0.53769066
178MP0009278_abnormal_bone_marrow0.53463660
179MP0000703_abnormal_thymus_morphology0.52926001
180MP0009643_abnormal_urine_homeostasis0.51928030
181MP0002722_abnormal_immune_system0.51087961
182MP0005360_urolithiasis0.51011518
183MP0000609_abnormal_liver_physiology0.50864312
184MP0000465_gastrointestinal_hemorrhage0.50544864
185MP0000689_abnormal_spleen_morphology0.50476924
186MP0004043_abnormal_pH_regulation0.49212885
187MP0009785_altered_susceptibility_to0.49110425
188MP0008469_abnormal_protein_level0.47919015
189MP0005166_decreased_susceptibility_to0.47819315
190MP0005621_abnormal_cell_physiology0.47591870
191MP0005670_abnormal_white_adipose0.47344481
192MP0000490_abnormal_crypts_of0.46879519
193MP0005165_increased_susceptibility_to0.46528210

Predicted human phenotypes

RankGene SetZ-score
1Ocular albinism (HP:0001107)8.30426968
2Iris hypopigmentation (HP:0007730)7.05490644
3Focal motor seizures (HP:0011153)6.69547194
4Aplasia/Hypoplasia of the macula (HP:0008059)6.25103598
5Aplasia/Hypoplasia affecting the retina (HP:0008061)5.73834138
6Blue irides (HP:0000635)5.12317923
7Myokymia (HP:0002411)5.04083135
8Focal seizures (HP:0007359)4.48491251
9Epileptic encephalopathy (HP:0200134)4.39457571
10White forelock (HP:0002211)4.38675127
11Atonic seizures (HP:0010819)4.24871767
12Patchy hypopigmentation of hair (HP:0011365)4.10520090
13Hypoplasia of the fovea (HP:0007750)3.99028591
14Aplasia/Hypoplasia of the fovea (HP:0008060)3.99028591
15Visual hallucinations (HP:0002367)3.96318946
16Hypopigmentation of the fundus (HP:0007894)3.94948514
17Febrile seizures (HP:0002373)3.93733730
18Generalized hypopigmentation (HP:0007513)3.84208984
19Pheochromocytoma (HP:0002666)3.73388874
20Eczematoid dermatitis (HP:0000976)3.48883445
21Acute necrotizing encephalopathy (HP:0006965)3.42247390
22Neuroendocrine neoplasm (HP:0100634)3.41787268
23Progressive cerebellar ataxia (HP:0002073)3.39358848
24Abnormal mitochondria in muscle tissue (HP:0008316)3.37340398
25Albinism (HP:0001022)3.33824581
26Hyperventilation (HP:0002883)3.33513584
27Absence seizures (HP:0002121)3.31595178
28Termporal pattern (HP:0011008)3.31173118
29Insidious onset (HP:0003587)3.31173118
30Cholecystitis (HP:0001082)3.29694304
31Abnormal gallbladder physiology (HP:0012438)3.29694304
32Generalized tonic-clonic seizures (HP:0002069)3.26697220
33Abnormality of the fovea (HP:0000493)3.16330313
34Dialeptic seizures (HP:0011146)3.10757612
35Progressive macrocephaly (HP:0004481)3.10611444
36Freckling (HP:0001480)3.06550151
37Supranuclear gaze palsy (HP:0000605)3.03750995
38Increased serum pyruvate (HP:0003542)3.02907086
39Abnormality of glycolysis (HP:0004366)3.02907086
40Progressive inability to walk (HP:0002505)3.02831179
41Broad-based gait (HP:0002136)2.98187835
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.91587645
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.91587645
44Gaze-evoked nystagmus (HP:0000640)2.91165747
45Decreased central vision (HP:0007663)2.89552239
46Abnormality of glycolipid metabolism (HP:0010969)2.89377996
47Abnormality of liposaccharide metabolism (HP:0010968)2.89377996
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.89377996
49Impaired vibration sensation in the lower limbs (HP:0002166)2.89177062
50Truncal ataxia (HP:0002078)2.88263976
51Limb dystonia (HP:0002451)2.87126080
52Abnormality of the corticospinal tract (HP:0002492)2.86461103
53Gait imbalance (HP:0002141)2.81327208
54Cutaneous melanoma (HP:0012056)2.81157176
55Mitochondrial inheritance (HP:0001427)2.80494446
56Congenital stationary night blindness (HP:0007642)2.78284797
57Bilateral sensorineural hearing impairment (HP:0008619)2.70103652
58Urinary urgency (HP:0000012)2.69608242
59Medial flaring of the eyebrow (HP:0010747)2.65507852
60Anxiety (HP:0000739)2.65118997
61Urinary bladder sphincter dysfunction (HP:0002839)2.65050164
62Abnormal hair whorl (HP:0010721)2.61091429
63Depression (HP:0000716)2.56904826
64Spastic gait (HP:0002064)2.56510793
65Action tremor (HP:0002345)2.55588993
66Hepatocellular necrosis (HP:0001404)2.55336515
67Dysmetria (HP:0001310)2.55010040
68Dysostosis multiplex (HP:0000943)2.54999869
69Acute encephalopathy (HP:0006846)2.54441777
70Dysdiadochokinesis (HP:0002075)2.51489672
71Central scotoma (HP:0000603)2.50123905
72Horizontal nystagmus (HP:0000666)2.48510409
73Ankle clonus (HP:0011448)2.48032301
74Frequent falls (HP:0002359)2.47898699
75Congenital primary aphakia (HP:0007707)2.45643841
76Drooling (HP:0002307)2.44113183
77Excessive salivation (HP:0003781)2.44113183
78Mutism (HP:0002300)2.43569688
79Hemorrhage of the eye (HP:0011885)2.42920410
80Increased CSF lactate (HP:0002490)2.41860090
81Poor eye contact (HP:0000817)2.41599733
82Ragged-red muscle fibers (HP:0003200)2.41382438
83Recurrent abscess formation (HP:0002722)2.39554284
84Optic disc pallor (HP:0000543)2.39453828
85Loss of speech (HP:0002371)2.39178822
86Amblyopia (HP:0000646)2.38511004
87Mucopolysacchariduria (HP:0008155)2.35090529
88Urinary glycosaminoglycan excretion (HP:0003541)2.35090529
89Abnormal eating behavior (HP:0100738)2.33634738
90Leukodystrophy (HP:0002415)2.32926586
91Recurrent bacterial skin infections (HP:0005406)2.31166000
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.31104315
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30743563
94Abnormality of polysaccharide metabolism (HP:0011012)2.30743563
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30743563
96Neurofibrillary tangles (HP:0002185)2.30739112
97Cerebral inclusion bodies (HP:0100314)2.30505362
98Nephrogenic diabetes insipidus (HP:0009806)2.30439717
99Lower limb muscle weakness (HP:0007340)2.29995395
100Increased connective tissue (HP:0009025)2.29942074
101Abnormality of binocular vision (HP:0011514)2.29672528
102Diplopia (HP:0000651)2.29672528
103Malnutrition (HP:0004395)2.26980690
104Exercise-induced myalgia (HP:0003738)2.26872427
105Premature graying of hair (HP:0002216)2.18288259
106Abnormal auditory evoked potentials (HP:0006958)2.17917076
107Fatigue (HP:0012378)2.17268238
108Epileptiform EEG discharges (HP:0011182)2.16241211
109Impaired social interactions (HP:0000735)2.15637440
110Abnormal social behavior (HP:0012433)2.15637440
111Increased cerebral lipofuscin (HP:0011813)2.14974053
112Scanning speech (HP:0002168)2.14221413
113Vertebral compression fractures (HP:0002953)2.12772407
114Dysmetric saccades (HP:0000641)2.12644015
115Petechiae (HP:0000967)2.11920406
116Colitis (HP:0002583)2.11502598
117Subaortic stenosis (HP:0001682)2.11048372
118Abnormality of the left ventricular outflow tract (HP:0011103)2.11048372
119Neoplasm of the peripheral nervous system (HP:0100007)2.10823551
120Inability to walk (HP:0002540)2.09821335
121Polyphagia (HP:0002591)2.08835175
122Heterochromia iridis (HP:0001100)2.08588295
123Congenital sensorineural hearing impairment (HP:0008527)2.07840827
124Genital tract atresia (HP:0001827)2.03736268
125Thin bony cortex (HP:0002753)2.00445111
126EEG with generalized epileptiform discharges (HP:0011198)2.00442703
127Vaginal atresia (HP:0000148)1.99944684
128Hypoplasia of the brainstem (HP:0002365)1.99890810
129Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99890810
130Agitation (HP:0000713)1.99780620
131Specific learning disability (HP:0001328)1.99547397
132Increased IgE level (HP:0003212)1.98887017
133Rhabdomyolysis (HP:0003201)1.97422633
134Abnormality of macrophages (HP:0004311)1.96789088
135Asymmetric septal hypertrophy (HP:0001670)1.96458487
136Systemic lupus erythematosus (HP:0002725)1.96351209
137Muscle hypertrophy of the lower extremities (HP:0008968)1.93915957
138Increased neuronal autofluorescent lipopigment (HP:0002074)1.93866706
139Sudden death (HP:0001699)1.93752761
140Cerebral hemorrhage (HP:0001342)1.93707714
141Distal lower limb muscle weakness (HP:0009053)1.93235434
142Broad face (HP:0000283)1.92558795
143Genetic anticipation (HP:0003743)1.92250398
144Gingivitis (HP:0000230)1.92182205
145Bradykinesia (HP:0002067)1.91634241
146Psychosis (HP:0000709)1.91588615
147Gastrointestinal stroma tumor (HP:0100723)1.91033824
148Shoulder girdle muscle weakness (HP:0003547)1.90954605
149Abnormality of pain sensation (HP:0010832)1.90203872
150Impaired pain sensation (HP:0007328)1.90203872
151Gastrointestinal inflammation (HP:0004386)1.89959030
152Cerebral aneurysm (HP:0004944)1.88339225
153Calf muscle hypertrophy (HP:0008981)1.87969288
154Hypsarrhythmia (HP:0002521)1.87245269
155Abnormality of the lower motor neuron (HP:0002366)1.87209695
156Slow saccadic eye movements (HP:0000514)1.86967021
157Muscle fibrillation (HP:0010546)1.86456598
158Centrally nucleated skeletal muscle fibers (HP:0003687)1.86299427
159Cellulitis (HP:0100658)1.85222242
160Generalized myoclonic seizures (HP:0002123)1.84645381
161Hypoplasia of the iris (HP:0007676)1.84459285
162Abnormality of saccadic eye movements (HP:0000570)1.84402375
163Focal dystonia (HP:0004373)1.84333806
164Impaired vibratory sensation (HP:0002495)1.84281469
165Abnormality of the calf musculature (HP:0001430)1.83582073
166Torticollis (HP:0000473)1.83500051
167Fetal akinesia sequence (HP:0001989)1.83050390
168Failure to thrive in infancy (HP:0001531)1.81613030
169Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79461989
170J-shaped sella turcica (HP:0002680)1.78484105
171Hypokinesia (HP:0002375)1.78399893
172Tongue fasciculations (HP:0001308)1.77095097
173Decreased motor nerve conduction velocity (HP:0003431)1.76129576
174Abdominal distention (HP:0003270)1.74400901
175Myopathic facies (HP:0002058)1.73992779
176Esophageal neoplasm (HP:0100751)1.71729050
177Neoplasm of head and neck (HP:0012288)1.71729050
178Hyperactive renin-angiotensin system (HP:0000841)1.68221668
179Inflammation of the large intestine (HP:0002037)1.67430095
180Cholelithiasis (HP:0001081)1.65339366
181Distal lower limb amyotrophy (HP:0008944)1.64909739
182Pustule (HP:0200039)1.64600777
183Meningitis (HP:0001287)1.64421189
184Interstitial pulmonary disease (HP:0006530)1.60752924
185Viral hepatitis (HP:0006562)1.60390932
186Ulnar bowing (HP:0003031)1.60130394
187Hyperparathyroidism (HP:0000843)1.57914615
188Hyperacusis (HP:0010780)1.56476723
189Recurrent fungal infections (HP:0002841)1.55857525
190Purpura (HP:0000979)1.55771947
191Osteomyelitis (HP:0002754)1.55555468
192Neuronal loss in central nervous system (HP:0002529)1.54189433
193Progressive neurologic deterioration (HP:0002344)1.54097079
194Abnormality of glutamine family amino acid metabolism (HP:0010902)1.54008897
195Growth hormone excess (HP:0000845)1.53913835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R3.98785975
2CASK3.41992010
3NTRK33.40036745
4MAP3K43.30824402
5MAP2K73.20651190
6TRIB33.15920880
7ERN13.14332728
8MARK13.03715211
9MAP3K122.94897517
10EPHA42.94434259
11MINK12.63404223
12GRK62.51937830
13MAP3K32.50374491
14MAP3K92.38862804
15SMG12.20871731
16MARK32.19676421
17WEE12.07906003
18MAP2K32.06497860
19PLK21.95748373
20TYK21.94024692
21MAP2K41.90379010
22CDK191.89576118
23DAPK21.89295976
24SIK11.82414869
25EEF2K1.81050902
26NTRK21.77544798
27MAP4K11.69792932
28ICK1.68381439
29RIPK41.63722496
30MAPK131.63495942
31GRK51.62207945
32PRPF4B1.60492275
33BCR1.58068275
34ZAP701.57624013
35NME21.54100699
36ARAF1.50146582
37RIPK11.46018329
38BLK1.42826335
39CDK51.38661760
40OXSR11.38182536
41CDK121.37245254
42NTRK11.36911355
43PAK61.36733065
44DAPK11.35703691
45KSR11.33595288
46TSSK61.31704889
47IRAK31.30579407
48NME11.28623129
49PDK41.27788354
50PDK31.27788354
51BMPR21.26560353
52TBK11.20696988
53PRKCG1.19401460
54FES1.18976045
55EPHB11.18201786
56PHKG21.17530744
57PHKG11.17530744
58TTN1.16900508
59TNK21.15954196
60PNCK1.15119751
61FGFR41.15011682
62TAOK11.12806607
63CAMK2A1.11501947
64KSR21.10885882
65PTK2B1.10457757
66CAMK2B1.10191169
67MAP3K11.06733573
68IRAK41.06529110
69UHMK11.05728801
70EIF2AK11.05400009
71GRK71.05327255
72MYLK1.05082606
73PDK21.04476425
74PTK61.03954538
75MAPK111.03941503
76WNK31.03887670
77MAPKAPK31.03794677
78TNIK1.03544532
79SGK2231.00670083
80SGK4941.00670083
81PDPK11.00330676
82PAK40.98175641
83SIK20.96055664
84TAOK20.95601603
85EPHA20.95326073
86ERBB30.94347576
87CDK180.93542164
88LIMK10.91853595
89CDK140.91565919
90PRKD20.89353227
91PAK30.87260134
92CDK60.86453926
93CDK150.85933662
94STK390.85868375
95MAP3K20.85159973
96CCNB10.84460682
97PRKCE0.83401149
98AKT30.82429077
99SCYL20.81337174
100MAP3K110.81312817
101MET0.80709304
102PKN20.79068874
103PKN10.78881521
104CSNK1G20.78630652
105PIM20.77097045
106MARK20.76956679
107MAP3K140.75350312
108CAMK2D0.72548910
109LMTK20.72337983
110CDK11A0.72021529
111FER0.70749902
112ACVR1B0.70316549
113CAMKK10.69487632
114TESK10.69457346
115SIK30.68318298
116DYRK1A0.67877770
117CAMKK20.67599959
118KIT0.67486103
119ROCK20.67476930
120MAP2K20.67270565
121PRKAA20.66268291
122PRKCH0.66262376
123MATK0.66080088
124PRKD10.65944329
125MAP3K130.65940920
126STK380.65407998
127FGR0.65334296
128MAP3K70.65218153
129NEK60.64692399
130ADRBK10.64676680
131CSNK1G30.64452474
132MTOR0.63541491
133CDK40.62609918
134CDK70.61680408
135JAK10.61408789
136MAP3K100.60646302
137SGK20.60392097
138JAK30.60119125
139LRRK20.59468577
140CSK0.59381134
141SYK0.59285368
142DYRK20.59046352
143FGFR30.57950909
144DAPK30.56682425
145PRKD30.55404070
146RET0.55278593
147BTK0.53959363
148CAMK2G0.53187278
149MAP3K60.53047153
150MAPK120.52744587
151AKT20.52441241
152FYN0.51657202
153WNK10.51646571
154RPS6KA20.50470201
155MAP2K10.50399434
156SGK10.50332527
157TESK20.49880276
158BRAF0.49767485
159ADRBK20.49682367
160MUSK0.49257999
161IRAK20.49047070
162NEK10.48784958
163HCK0.48682344
164JAK20.47673349
165PINK10.47594299
166OBSCN0.47590460
167FGFR20.47112408
168CDC42BPA0.45762608
169TYRO30.45008981
170RAF10.44839429
171LYN0.44837511
172MAPKAPK50.43119951
173PRKACA0.42591766
174MAPK70.41809478
175PDK10.41248861
176MAP3K80.39657337
177SGK30.38463132
178RPS6KL10.35081542
179RPS6KC10.35081542
180CSF1R0.33811625

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.63016715
2Nicotine addiction_Homo sapiens_hsa050333.62986630
3Other glycan degradation_Homo sapiens_hsa005113.47058815
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.09789928
5Pentose phosphate pathway_Homo sapiens_hsa000302.88507477
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71467560
7GABAergic synapse_Homo sapiens_hsa047272.66965783
8Collecting duct acid secretion_Homo sapiens_hsa049662.65612119
9Oxidative phosphorylation_Homo sapiens_hsa001902.53446045
10Fructose and mannose metabolism_Homo sapiens_hsa000512.50751232
11Morphine addiction_Homo sapiens_hsa050322.45962859
12Olfactory transduction_Homo sapiens_hsa047402.45961168
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.42569412
14Circadian entrainment_Homo sapiens_hsa047132.39778898
15Long-term potentiation_Homo sapiens_hsa047202.29601007
16Glutamatergic synapse_Homo sapiens_hsa047242.15737798
17Dopaminergic synapse_Homo sapiens_hsa047282.15565748
18Amphetamine addiction_Homo sapiens_hsa050312.14881547
19Parkinsons disease_Homo sapiens_hsa050122.11437370
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99164813
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98494819
22Cardiac muscle contraction_Homo sapiens_hsa042601.89083639
23Alzheimers disease_Homo sapiens_hsa050101.85953038
24Acute myeloid leukemia_Homo sapiens_hsa052211.83758648
25Osteoclast differentiation_Homo sapiens_hsa043801.83271332
26Vibrio cholerae infection_Homo sapiens_hsa051101.82217300
27Serotonergic synapse_Homo sapiens_hsa047261.80000612
28Renin secretion_Homo sapiens_hsa049241.79028249
29Lysosome_Homo sapiens_hsa041421.77933693
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73201599
31Cholinergic synapse_Homo sapiens_hsa047251.68721029
32Non-small cell lung cancer_Homo sapiens_hsa052231.66865365
33Taste transduction_Homo sapiens_hsa047421.65562573
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64478408
35Insulin secretion_Homo sapiens_hsa049111.61617640
36B cell receptor signaling pathway_Homo sapiens_hsa046621.61336910
37Salivary secretion_Homo sapiens_hsa049701.60080588
38Phototransduction_Homo sapiens_hsa047441.58627862
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57176458
40Long-term depression_Homo sapiens_hsa047301.57003399
41Cocaine addiction_Homo sapiens_hsa050301.49523604
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48225098
43Inositol phosphate metabolism_Homo sapiens_hsa005621.46604086
44Calcium signaling pathway_Homo sapiens_hsa040201.45179099
45Gastric acid secretion_Homo sapiens_hsa049711.45010604
46Oxytocin signaling pathway_Homo sapiens_hsa049211.42829867
47Galactose metabolism_Homo sapiens_hsa000521.40296152
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33869493
49Huntingtons disease_Homo sapiens_hsa050161.33040809
50Leishmaniasis_Homo sapiens_hsa051401.32487212
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29392534
52Toxoplasmosis_Homo sapiens_hsa051451.27380153
53Tyrosine metabolism_Homo sapiens_hsa003501.27039678
54Chronic myeloid leukemia_Homo sapiens_hsa052201.24020694
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20644127
56Prostate cancer_Homo sapiens_hsa052151.20525352
57Biosynthesis of amino acids_Homo sapiens_hsa012301.19772360
58Adipocytokine signaling pathway_Homo sapiens_hsa049201.19156304
59Tuberculosis_Homo sapiens_hsa051521.17074714
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16779171
61Thyroid cancer_Homo sapiens_hsa052161.16197782
62Pancreatic cancer_Homo sapiens_hsa052121.16089390
63Dilated cardiomyopathy_Homo sapiens_hsa054141.14366071
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14348002
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13651975
66Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13386757
67Axon guidance_Homo sapiens_hsa043601.12895216
68Small cell lung cancer_Homo sapiens_hsa052221.12088148
69Hepatitis B_Homo sapiens_hsa051611.10662234
70Arginine biosynthesis_Homo sapiens_hsa002201.10528363
71Herpes simplex infection_Homo sapiens_hsa051681.09597553
72Hepatitis C_Homo sapiens_hsa051601.08550225
73Gap junction_Homo sapiens_hsa045401.07360317
74Influenza A_Homo sapiens_hsa051641.07082451
75NF-kappa B signaling pathway_Homo sapiens_hsa040641.05544548
76Carbon metabolism_Homo sapiens_hsa012001.03806114
77GnRH signaling pathway_Homo sapiens_hsa049121.02244335
78Measles_Homo sapiens_hsa051621.01644922
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99078066
80Sulfur metabolism_Homo sapiens_hsa009200.97887001
81cAMP signaling pathway_Homo sapiens_hsa040240.97139292
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97013014
83Endometrial cancer_Homo sapiens_hsa052130.95985432
84Sphingolipid metabolism_Homo sapiens_hsa006000.94204752
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93428048
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92427117
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91324983
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90944768
89mTOR signaling pathway_Homo sapiens_hsa041500.90639536
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89275880
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88866150
92Staphylococcus aureus infection_Homo sapiens_hsa051500.88094797
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.88067812
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86714433
95Rheumatoid arthritis_Homo sapiens_hsa053230.85770115
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85415032
97Phagosome_Homo sapiens_hsa041450.85388692
98Viral myocarditis_Homo sapiens_hsa054160.84616160
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83199984
100Type I diabetes mellitus_Homo sapiens_hsa049400.82965411
101Allograft rejection_Homo sapiens_hsa053300.82523353
102Insulin signaling pathway_Homo sapiens_hsa049100.82396692
103Insulin resistance_Homo sapiens_hsa049310.81771975
104Type II diabetes mellitus_Homo sapiens_hsa049300.81561131
105Apoptosis_Homo sapiens_hsa042100.80513686
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77803952
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77076389
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76894239
109TNF signaling pathway_Homo sapiens_hsa046680.76707939
110Autoimmune thyroid disease_Homo sapiens_hsa053200.76167632
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.76074234
112Epstein-Barr virus infection_Homo sapiens_hsa051690.75426031
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74825633
114Oocyte meiosis_Homo sapiens_hsa041140.74416789
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.72371474
116ErbB signaling pathway_Homo sapiens_hsa040120.72348045
117Shigellosis_Homo sapiens_hsa051310.72316290
118Notch signaling pathway_Homo sapiens_hsa043300.71490732
119Bladder cancer_Homo sapiens_hsa052190.71398938
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.70022389
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69752621
122Choline metabolism in cancer_Homo sapiens_hsa052310.69531503
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69117092
124Estrogen signaling pathway_Homo sapiens_hsa049150.68302632
125Glutathione metabolism_Homo sapiens_hsa004800.67686567
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.67109108
127Legionellosis_Homo sapiens_hsa051340.66783988
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66534891
129Non-homologous end-joining_Homo sapiens_hsa034500.64448981
130Glioma_Homo sapiens_hsa052140.64386911
131Pyruvate metabolism_Homo sapiens_hsa006200.63451864
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62120915
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60546354
134Melanogenesis_Homo sapiens_hsa049160.60487952
135Graft-versus-host disease_Homo sapiens_hsa053320.59641824
136Viral carcinogenesis_Homo sapiens_hsa052030.59377164
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58521170
138Starch and sucrose metabolism_Homo sapiens_hsa005000.57728583
139Antigen processing and presentation_Homo sapiens_hsa046120.56632879
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56391583
141AMPK signaling pathway_Homo sapiens_hsa041520.56384354
142T cell receptor signaling pathway_Homo sapiens_hsa046600.55930491
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.54641419
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53917514
145Primary immunodeficiency_Homo sapiens_hsa053400.51670071
146Butanoate metabolism_Homo sapiens_hsa006500.50664123
147MAPK signaling pathway_Homo sapiens_hsa040100.50091773
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49923123
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49767974
150HIF-1 signaling pathway_Homo sapiens_hsa040660.49628793
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47994178
152Fatty acid elongation_Homo sapiens_hsa000620.47622482
153Prolactin signaling pathway_Homo sapiens_hsa049170.47538506
154Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46294465
155Endocytosis_Homo sapiens_hsa041440.45436108
156Alcoholism_Homo sapiens_hsa050340.45053834
157Ras signaling pathway_Homo sapiens_hsa040140.42465440
158Pancreatic secretion_Homo sapiens_hsa049720.40446449
159Glucagon signaling pathway_Homo sapiens_hsa049220.39468852
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.37905612
161Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36828357
162Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31039226
163Prion diseases_Homo sapiens_hsa050200.30866349
164Neurotrophin signaling pathway_Homo sapiens_hsa047220.30278511
165Renal cell carcinoma_Homo sapiens_hsa052110.30199017
166Rap1 signaling pathway_Homo sapiens_hsa040150.29153973
167Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28817521
168Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28330493
169Phospholipase D signaling pathway_Homo sapiens_hsa040720.28164284
170Thyroid hormone synthesis_Homo sapiens_hsa049180.27854435
171African trypanosomiasis_Homo sapiens_hsa051430.27116048
172Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26626709
173VEGF signaling pathway_Homo sapiens_hsa043700.25565623
174Regulation of autophagy_Homo sapiens_hsa041400.24675442
175Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23609873
176Ovarian steroidogenesis_Homo sapiens_hsa049130.21406981
177Salmonella infection_Homo sapiens_hsa051320.19855225
178Colorectal cancer_Homo sapiens_hsa052100.19401700
179Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18127041

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