EXOC3L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)9.16140609
2lymph vessel development (GO:0001945)6.62692071
3vascular endothelial growth factor signaling pathway (GO:0038084)5.68421613
4plasma membrane fusion (GO:0045026)5.45875754
5cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.28022664
6acrosome reaction (GO:0007340)5.24602294
7negative regulation of blood vessel endothelial cell migration (GO:0043537)5.08249514
8fusion of sperm to egg plasma membrane (GO:0007342)5.07575925
9endothelial tube morphogenesis (GO:0061154)5.05158211
10morphogenesis of an endothelium (GO:0003159)5.05158211
11basement membrane organization (GO:0071711)4.82047664
12positive regulation of protein kinase C signaling (GO:0090037)4.70993775
13sperm capacitation (GO:0048240)4.63342666
14lymphangiogenesis (GO:0001946)4.50519859
15retina vasculature morphogenesis in camera-type eye (GO:0061299)4.49644647
16regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.45318089
17sperm motility (GO:0030317)4.41129255
18hyaluronan catabolic process (GO:0030214)4.32607073
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29995979
20regulation of T-helper 2 cell differentiation (GO:0045628)4.08317226
21vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.06468650
22Notch signaling involved in heart development (GO:0061314)4.02291432
23regulation of endothelial cell differentiation (GO:0045601)3.93501798
24blood vessel maturation (GO:0001955)3.89068637
25sexual reproduction (GO:0019953)3.76093230
26endothelial cell differentiation (GO:0045446)3.71090859
27positive regulation of endothelial cell differentiation (GO:0045603)3.64448777
28endothelial cell chemotaxis (GO:0035767)3.58183459
29negative regulation of endothelial cell migration (GO:0010596)3.57053117
30angiogenesis involved in wound healing (GO:0060055)3.49792296
31patterning of blood vessels (GO:0001569)3.46744684
32chromosome condensation (GO:0030261)3.43013412
33ventricular trabecula myocardium morphogenesis (GO:0003222)3.41387486
34negative regulation of Rho protein signal transduction (GO:0035024)3.34450615
35regulation of ARF GTPase activity (GO:0032312)3.34019414
36semaphorin-plexin signaling pathway (GO:0071526)3.26213066
37response to pheromone (GO:0019236)3.25250389
38positive regulation of vasculogenesis (GO:2001214)3.24052002
39phosphatidylethanolamine biosynthetic process (GO:0006646)3.21155554
40DNA packaging (GO:0006323)3.19701068
41trabecula morphogenesis (GO:0061383)3.10309010
42peptidyl-tyrosine autophosphorylation (GO:0038083)3.10243566
43regulation of blood vessel endothelial cell migration (GO:0043535)3.08388523
44sprouting angiogenesis (GO:0002040)3.05672830
45single strand break repair (GO:0000012)3.04437085
46cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.03785766
47negative regulation of inclusion body assembly (GO:0090084)3.03700022
48glomerular filtration (GO:0003094)3.02077212
49response to acidic pH (GO:0010447)2.97056987
50spermatid development (GO:0007286)2.96805129
51negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.96647825
52blood vessel endothelial cell migration (GO:0043534)2.95438491
53positive regulation of type 2 immune response (GO:0002830)2.92072150
54protein kinase C signaling (GO:0070528)2.91199452
55spermatid nucleus differentiation (GO:0007289)2.88184180
56regulation of vasculogenesis (GO:2001212)2.81621621
57phosphatidylethanolamine metabolic process (GO:0046337)2.80410747
58insulin-like growth factor receptor signaling pathway (GO:0048009)2.76417381
59positive regulation of Cdc42 GTPase activity (GO:0043089)2.75576725
60regulation of Rab GTPase activity (GO:0032313)2.75459332
61positive regulation of Rab GTPase activity (GO:0032851)2.75459332
62renal filtration (GO:0097205)2.73656564
63cellular response to pH (GO:0071467)2.73403266
64peptide catabolic process (GO:0043171)2.72535338
65coronary vasculature morphogenesis (GO:0060977)2.69368487
66RNA destabilization (GO:0050779)2.68989102
67reproduction (GO:0000003)2.68541792
68cell migration involved in sprouting angiogenesis (GO:0002042)2.68479330
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.67763852
70Notch receptor processing (GO:0007220)2.66196163
71heart trabecula morphogenesis (GO:0061384)2.65618877
72type I interferon signaling pathway (GO:0060337)2.64699283
73cellular response to type I interferon (GO:0071357)2.64699283
74regulation of transcription involved in cell fate commitment (GO:0060850)2.64369044
75regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.62215774
76response to type I interferon (GO:0034340)2.61758631
77negative regulation of Notch signaling pathway (GO:0045746)2.58780744
78surfactant homeostasis (GO:0043129)2.56728388
79substrate-dependent cell migration (GO:0006929)2.55529680
80NIK/NF-kappaB signaling (GO:0038061)2.55352197
81ganglion development (GO:0061548)2.55000628
82regulation of somitogenesis (GO:0014807)2.53652338
83stress fiber assembly (GO:0043149)2.52706016
84negative regulation of granulocyte differentiation (GO:0030853)2.51837033
85regulation of protein kinase C signaling (GO:0090036)2.49981029
86calcium ion-dependent exocytosis (GO:0017156)2.49406156
87epithelial cell fate commitment (GO:0072148)2.49026445
88neuron remodeling (GO:0016322)2.48902620
89microtubule severing (GO:0051013)2.46675810
90negative regulation of platelet activation (GO:0010544)2.46233113
91mRNA transcription from RNA polymerase II promoter (GO:0042789)2.44422852
92apoptotic process involved in morphogenesis (GO:0060561)2.43983693
93negative regulation of epithelial cell migration (GO:0010633)2.43963661
94multicellular organism reproduction (GO:0032504)2.43925998
95negative regulation of erythrocyte differentiation (GO:0045647)2.43669023
96membrane protein intracellular domain proteolysis (GO:0031293)2.42503211
97negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.42048947
98endothelial cell morphogenesis (GO:0001886)2.40408370
99chromatin silencing (GO:0006342)2.40067670
100labyrinthine layer development (GO:0060711)2.38153315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.84152184
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.54219274
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.45611360
4LXR_22292898_ChIP-Seq_THP-1_Human3.23530328
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.92333919
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.74882717
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.73532672
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.62595349
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50257487
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.08738141
11P68_20966046_ChIP-Seq_HELA_Human2.06484900
12GATA2_21666600_ChIP-Seq_HMVEC_Human1.98739478
13KDM2B_26808549_Chip-Seq_DND41_Human1.96152955
14SMC4_20622854_ChIP-Seq_HELA_Human1.88347201
15CTCF_27219007_Chip-Seq_Bcells_Human1.88051759
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86675682
17BCL6_27268052_Chip-Seq_Bcells_Human1.85996238
18TCF7_22412390_ChIP-Seq_EML_Mouse1.81168424
19KDM2B_26808549_Chip-Seq_K562_Human1.80338377
20DROSHA_22980978_ChIP-Seq_HELA_Human1.77958891
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75508409
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73965808
23BCOR_27268052_Chip-Seq_Bcells_Human1.70712688
24RACK7_27058665_Chip-Seq_MCF-7_Human1.69021996
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66674748
26SA1_27219007_Chip-Seq_ERYTHROID_Human1.65069064
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60532505
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58945338
29CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58908604
30EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55864731
31PHF8_20622854_ChIP-Seq_HELA_Human1.55199972
32SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.51507802
33E2F1_20622854_ChIP-Seq_HELA_Human1.50861292
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47435335
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.46365678
36TP63_22573176_ChIP-Seq_HFKS_Human1.45811467
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.45713183
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.45435667
39VDR_21846776_ChIP-Seq_THP-1_Human1.43865735
40SA1_27219007_Chip-Seq_Bcells_Human1.43130727
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39646592
42SPI1_23127762_ChIP-Seq_K562_Human1.39635586
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37843129
44CTCF_20526341_ChIP-Seq_ESCs_Human1.36883779
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33816896
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30167766
47YY1_22570637_ChIP-Seq_MALME-3M_Human1.28742930
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26916038
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25454395
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25362108
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.24865426
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23797901
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23041945
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22620368
55VDR_24763502_ChIP-Seq_THP-1_Human1.21247846
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20023919
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.19965474
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17381801
59GATA1_19941826_ChIP-Seq_K562_Human1.16824254
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16672391
61CTCF_21964334_Chip-Seq_Bcells_Human1.14174314
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.13292198
63TP53_22127205_ChIP-Seq_IMR90_Human1.12883103
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.12849483
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12595158
66JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10915785
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10359602
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.09924520
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08687207
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08370792
71OCT4_19829295_ChIP-Seq_ESCs_Human1.08307590
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08237658
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08233304
74P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07439165
75RAC3_21632823_ChIP-Seq_H3396_Human1.07385963
76CREB1_26743006_Chip-Seq_LNCaP_Human1.07232715
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06402983
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05899770
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05797244
80MAF_26560356_Chip-Seq_TH1_Human1.05166938
81MAF_26560356_Chip-Seq_TH2_Human1.05085430
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04627968
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.03995543
84P300_27268052_Chip-Seq_Bcells_Human1.03537468
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02928917
86RUNX_20019798_ChIP-Seq_JUKART_Human1.02870034
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.02711972
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02293488
89SCL_19346495_ChIP-Seq_HPC-7_Human1.02104790
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.01906125
91SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01517591
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01184466
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99698988
94CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99681458
95UTX_26944678_Chip-Seq_JUKART_Human0.97883509
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96920822
97NCOR1_26117541_ChIP-Seq_K562_Human0.95787989
98KLF4_19829295_ChIP-Seq_ESCs_Human0.95644774
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.95552673
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95226158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.61375216
2MP0001879_abnormal_lymphatic_vessel5.12732641
3MP0005410_abnormal_fertilization4.37663816
4MP0003303_peritoneal_inflammation3.86176655
5MP0005167_abnormal_blood-brain_barrier3.67802230
6MP0003724_increased_susceptibility_to3.54450564
7MP0004272_abnormal_basement_membrane3.14265138
8MP0003828_pulmonary_edema2.80501610
9MP0005670_abnormal_white_adipose2.54001320
10MP0002138_abnormal_hepatobiliary_system2.28205353
11MP0003705_abnormal_hypodermis_morpholog2.23338808
12MP0004510_myositis2.16925827
13MP0005409_darkened_coat_color2.10123045
14MP0000465_gastrointestinal_hemorrhage2.08521051
15MP0000013_abnormal_adipose_tissue2.03585386
16MP0000767_abnormal_smooth_muscle2.00736401
17MP0005451_abnormal_body_composition1.97288566
18MP0005377_hearing/vestibular/ear_phenot1.89905139
19MP0003878_abnormal_ear_physiology1.89905139
20MP0005058_abnormal_lysosome_morphology1.85840628
21MP0000678_abnormal_parathyroid_gland1.76232926
22MP0003279_aneurysm1.74226284
23MP0005595_abnormal_vascular_smooth1.72709969
24MP0002933_joint_inflammation1.61239994
25MP0003436_decreased_susceptibility_to1.60910552
26MP0002332_abnormal_exercise_endurance1.60280171
27MP0000003_abnormal_adipose_tissue1.53886924
28MP0002127_abnormal_cardiovascular_syste1.50764714
29MP0003300_gastrointestinal_ulcer1.46065622
30MP0000249_abnormal_blood_vessel1.44404054
31MP0002822_catalepsy1.42221414
32MP0005375_adipose_tissue_phenotype1.41189607
33MP0001849_ear_inflammation1.40235414
34MP0003091_abnormal_cell_migration1.35402126
35MP0005165_increased_susceptibility_to1.32078280
36MP0001533_abnormal_skeleton_physiology1.31487682
37MP0009785_altered_susceptibility_to1.27903384
38MP0000751_myopathy1.26416100
39MP0001348_abnormal_lacrimal_gland1.26121719
40MP0001614_abnormal_blood_vessel1.18211213
41MP0008260_abnormal_autophagy1.16292321
42MP0002295_abnormal_pulmonary_circulatio1.15233211
43MP0009278_abnormal_bone_marrow1.13490385
44MP0003879_abnormal_hair_cell1.10905292
45MP0005666_abnormal_adipose_tissue1.07473316
46MP0004084_abnormal_cardiac_muscle1.05767407
47MP0005025_abnormal_response_to1.05602465
48MP0004484_altered_response_of1.05582566
49MP0004782_abnormal_surfactant_physiolog1.05192954
50MP0009764_decreased_sensitivity_to1.04624786
51MP0009840_abnormal_foam_cell1.03010266
52MP0002419_abnormal_innate_immunity1.02873040
53MP0002249_abnormal_larynx_morphology1.02268452
54MP0006082_CNS_inflammation1.00283738
55MP0003172_abnormal_lysosome_physiology0.93997977
56MP0002925_abnormal_cardiovascular_devel0.93202569
57MP0006138_congestive_heart_failure0.91934002
58MP0004858_abnormal_nervous_system0.91681970
59MP0002132_abnormal_respiratory_system0.90426036
60MP0009053_abnormal_anal_canal0.89594329
61MP0003698_abnormal_male_reproductive0.88790719
62MP0000750_abnormal_muscle_regeneration0.86724485
63MP0008874_decreased_physiological_sensi0.86317860
64MP0003566_abnormal_cell_adhesion0.84243377
65MP0005623_abnormal_meninges_morphology0.82025473
66MP0003191_abnormal_cellular_cholesterol0.79363554
67MP0002998_abnormal_bone_remodeling0.78423341
68MP0000343_altered_response_to0.78079717
69MP0004947_skin_inflammation0.76228575
70MP0004036_abnormal_muscle_relaxation0.74476825
71MP0001915_intracranial_hemorrhage0.73713178
72MP0004233_abnormal_muscle_weight0.72865895
73MP0003075_altered_response_to0.72317034
74MP0002128_abnormal_blood_circulation0.71512045
75MP0005390_skeleton_phenotype0.68695601
76MP0005310_abnormal_salivary_gland0.67998841
77MP0000747_muscle_weakness0.66879465
78MP0003690_abnormal_glial_cell0.66811022
79MP0005387_immune_system_phenotype0.65357511
80MP0001790_abnormal_immune_system0.65357511
81MP0005000_abnormal_immune_tolerance0.64595289
82MP0008004_abnormal_stomach_pH0.63122783
83MP0010630_abnormal_cardiac_muscle0.62667731
84MP0005166_decreased_susceptibility_to0.61714476
85MP0003948_abnormal_gas_homeostasis0.59824245
86MP0002796_impaired_skin_barrier0.57035589
87MP0005464_abnormal_platelet_physiology0.56316854
88MP0004883_abnormal_blood_vessel0.56225482
89MP0005164_abnormal_response_to0.55190604
90MP0010155_abnormal_intestine_physiology0.54365448
91MP0002161_abnormal_fertility/fecundity0.53824471
92MP0001929_abnormal_gametogenesis0.53400303
93MP0008469_abnormal_protein_level0.52560530
94MP0002932_abnormal_joint_morphology0.49489089
95MP0003453_abnormal_keratinocyte_physiol0.49032294
96MP0000733_abnormal_muscle_development0.48103109
97MP0003448_altered_tumor_morphology0.47664417
98MP0010030_abnormal_orbit_morphology0.47381170
99MP0001819_abnormal_immune_cell0.47211798
100MP0004085_abnormal_heartbeat0.46433216

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the nasal mucosa (HP:0000433)4.47549752
2Nonimmune hydrops fetalis (HP:0001790)4.46592433
3Cerebral aneurysm (HP:0004944)4.31906370
4Lymphangioma (HP:0100764)4.22203275
5Asymmetric septal hypertrophy (HP:0001670)4.21052125
6Esophageal varix (HP:0002040)3.94817627
7Hemorrhage of the eye (HP:0011885)3.81938109
8Difficulty climbing stairs (HP:0003551)3.55601714
9Spontaneous hematomas (HP:0007420)3.51472403
10Increased connective tissue (HP:0009025)3.38687788
11Severe visual impairment (HP:0001141)3.36808321
12Polycythemia (HP:0001901)3.36125188
13Muscle fiber splitting (HP:0003555)3.09516201
14Broad face (HP:0000283)2.99980097
15Portal hypertension (HP:0001409)2.86564994
16Porencephaly (HP:0002132)2.82173763
17Nuclear cataract (HP:0100018)2.78426811
18Nasal polyposis (HP:0100582)2.75212828
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.73579912
20Hematochezia (HP:0002573)2.73261150
21Systemic lupus erythematosus (HP:0002725)2.70538594
22Abnormality of the hepatic vasculature (HP:0006707)2.61774931
23Absent hand (HP:0004050)2.54844481
24Thin bony cortex (HP:0002753)2.52270522
25Eczematoid dermatitis (HP:0000976)2.51938743
26Visceral angiomatosis (HP:0100761)2.44242884
27Distal lower limb muscle weakness (HP:0009053)2.42973421
28Protrusio acetabuli (HP:0003179)2.42853478
29Hemiplegia (HP:0002301)2.38946254
30Capillary hemangiomas (HP:0005306)2.38047224
31Ectopia lentis (HP:0001083)2.36416831
32Stroke (HP:0001297)2.34648033
33Abnormality of macrophages (HP:0004311)2.33985118
34Skull defect (HP:0001362)2.33264734
35Difficulty running (HP:0009046)2.31223605
36Male infertility (HP:0003251)2.28472049
37Cervical subluxation (HP:0003308)2.27113136
38Easy fatigability (HP:0003388)2.27064038
39Neoplasm of the heart (HP:0100544)2.26127378
40Spinal rigidity (HP:0003306)2.26087867
41Gingivitis (HP:0000230)2.24487399
42Distal lower limb amyotrophy (HP:0008944)2.21571166
43Increased variability in muscle fiber diameter (HP:0003557)2.21272133
44Orchitis (HP:0100796)2.20910811
45Myositis (HP:0100614)2.20071191
46Vertebral clefting (HP:0008428)2.19739937
47Hemangiomatosis (HP:0007461)2.18301695
48Ventricular tachycardia (HP:0004756)2.18042784
49Wrist flexion contracture (HP:0001239)2.17471556
50Hypertriglyceridemia (HP:0002155)2.16453734
51Bulbar palsy (HP:0001283)2.16141713
52Pulmonary hypertension (HP:0002092)2.13865690
53Tetraparesis (HP:0002273)2.11681359
54Gastrointestinal infarctions (HP:0005244)2.10992945
55Adactyly (HP:0009776)2.05374353
56Abnormality of skeletal muscle fiber size (HP:0012084)2.02379613
57Bell-shaped thorax (HP:0001591)2.02363715
58Interstitial pulmonary disease (HP:0006530)2.02022554
59Axonal loss (HP:0003447)2.01109492
60Centrally nucleated skeletal muscle fibers (HP:0003687)1.98132402
61Abnormality of complement system (HP:0005339)1.97487206
62Myocardial infarction (HP:0001658)1.96811276
63Enlarged epiphyses (HP:0010580)1.96309972
64Chronic obstructive pulmonary disease (HP:0006510)1.96013845
65Obstructive lung disease (HP:0006536)1.96013845
66Amyloidosis (HP:0011034)1.95735117
67Retrobulbar optic neuritis (HP:0100654)1.92382590
68Optic neuritis (HP:0100653)1.92382590
69Lumbar hyperlordosis (HP:0002938)1.91159535
70Peritonitis (HP:0002586)1.90911274
71Hemoptysis (HP:0002105)1.90349775
72Abnormality of liposaccharide metabolism (HP:0010968)1.87780620
73Abnormality of glycosphingolipid metabolism (HP:0004343)1.87780620
74Abnormality of glycolipid metabolism (HP:0010969)1.87780620
75Premature rupture of membranes (HP:0001788)1.86458423
76Aneurysm (HP:0002617)1.85745830
77Resting tremor (HP:0002322)1.84404865
78J-shaped sella turcica (HP:0002680)1.84250159
79Recurrent gram-negative bacterial infections (HP:0005420)1.82598097
80Hyporeflexia of lower limbs (HP:0002600)1.81606119
81Neonatal death (HP:0003811)1.81563456
82Polygenic inheritance (HP:0010982)1.81502457
83Joint stiffness (HP:0001387)1.79684676
84Abnormality of the ischium (HP:0003174)1.79307854
85Coxa vara (HP:0002812)1.77221753
86Upper limb amyotrophy (HP:0009129)1.76483902
87Distal upper limb amyotrophy (HP:0007149)1.76483902
88Facial shape deformation (HP:0011334)1.76237381
89Potter facies (HP:0002009)1.76237381
90Hyperlipoproteinemia (HP:0010980)1.75660367
91Recurrent abscess formation (HP:0002722)1.75571156
92Purpura (HP:0000979)1.74124414
93Nephritis (HP:0000123)1.73523061
94Atelectasis (HP:0100750)1.72943508
95Segmental peripheral demyelination/remyelination (HP:0003481)1.72895763
96Abnormality of the peritoneum (HP:0002585)1.72354827
97Venous abnormality (HP:0002624)1.72162738
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72146141
99Abnormality of polysaccharide metabolism (HP:0011012)1.72146141
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72146141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.78333155
2KDR6.87681553
3TESK13.31766811
4RIPK12.77726409
5DDR22.33990799
6MAP3K112.23354335
7FES2.21041925
8TRIB32.18458494
9PRKG21.59406928
10PLK41.57472571
11EPHB21.57119506
12MAP2K31.56114025
13FER1.48847548
14ERN11.45687587
15KSR21.37752296
16CSK1.34958445
17PRKD31.34016634
18TGFBR21.32290507
19MAP4K11.27223076
20MARK21.20689121
21PTK2B1.19150430
22SIK11.15218430
23MAP3K11.14765632
24DYRK1B1.14725191
25MAP3K131.14107618
26STK381.13672487
27PDPK11.13612387
28RPS6KA21.06117720
29PRPF4B1.05473753
30TESK21.04936753
31ARAF1.04722792
32TBK11.03636070
33EPHB11.02919648
34MOS1.00333867
35FGFR40.99817768
36ZAP700.98990223
37PRKD20.96893966
38RIPK40.94796156
39TNK20.92406353
40MAP3K30.90424947
41PKN20.88453275
42JAK30.88348674
43SMG10.87527581
44PDGFRA0.85888968
45PRKAA20.85752620
46EEF2K0.84357469
47BLK0.84264576
48LMTK20.83683163
49MAP3K70.82281431
50ICK0.78368885
51TAOK10.77549728
52PDK10.75543467
53TAOK20.74832845
54NTRK10.73620119
55IRAK30.71851087
56MAP3K60.70336545
57TYRO30.65087803
58MAP2K60.64029765
59PTK60.63195260
60HCK0.61915367
61PAK40.60808696
62TYK20.59463337
63RPS6KC10.59450849
64RPS6KL10.59450849
65TTN0.56090911
66FGR0.55429017
67MAP3K90.53971605
68MAP2K20.53214407
69MAP3K140.52875720
70MAPK150.49250115
71INSRR0.47780436
72MAPK120.45944197
73CDC42BPA0.45263564
74RPS6KA60.44165558
75IRAK40.44039973
76LATS20.42898222
77CDK70.42586992
78PIK3CG0.42423478
79BMX0.41821899
80IKBKE0.38021915
81BRAF0.37443719
82MTOR0.37382430
83MAPK70.37014192
84ROCK10.36068507
85GRK60.33428823
86CHUK0.32054622
87NTRK30.31591362
88PTK20.31407308
89MUSK0.31076500
90RET0.30927681
91MET0.30205817
92RPS6KA10.30146238
93LYN0.30066579
94IKBKB0.29383415
95SRC0.29289538
96MAP3K80.28177062
97LCK0.27196416
98MATK0.27101299
99MST1R0.26321010
100CDK120.26110495

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.46798822
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.20898861
3Other glycan degradation_Homo sapiens_hsa005112.14815804
4Fatty acid biosynthesis_Homo sapiens_hsa000612.08249790
5VEGF signaling pathway_Homo sapiens_hsa043701.92951948
6Prion diseases_Homo sapiens_hsa050201.73993074
7Malaria_Homo sapiens_hsa051441.71203593
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70782660
9Dorso-ventral axis formation_Homo sapiens_hsa043201.68496649
10Osteoclast differentiation_Homo sapiens_hsa043801.67752555
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.57975962
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52821885
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52136446
14Leishmaniasis_Homo sapiens_hsa051401.44821242
15ECM-receptor interaction_Homo sapiens_hsa045121.42994517
16Focal adhesion_Homo sapiens_hsa045101.42920107
17Endocytosis_Homo sapiens_hsa041441.40041407
18Acute myeloid leukemia_Homo sapiens_hsa052211.35895962
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35239989
20Rap1 signaling pathway_Homo sapiens_hsa040151.30326544
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.29650799
22Pertussis_Homo sapiens_hsa051331.28109417
23Amoebiasis_Homo sapiens_hsa051461.28081954
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25819296
25Toxoplasmosis_Homo sapiens_hsa051451.23085307
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21536634
27Influenza A_Homo sapiens_hsa051641.20179436
28Staphylococcus aureus infection_Homo sapiens_hsa051501.19247217
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17108517
30Arginine biosynthesis_Homo sapiens_hsa002201.12683746
31Bladder cancer_Homo sapiens_hsa052191.11751778
32TNF signaling pathway_Homo sapiens_hsa046681.10391886
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09138088
34Phospholipase D signaling pathway_Homo sapiens_hsa040721.05768600
35Salmonella infection_Homo sapiens_hsa051321.04031319
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.02344867
37Chemokine signaling pathway_Homo sapiens_hsa040621.01143692
38Allograft rejection_Homo sapiens_hsa053300.98397358
39Viral myocarditis_Homo sapiens_hsa054160.97975616
40Shigellosis_Homo sapiens_hsa051310.96548526
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95068950
42B cell receptor signaling pathway_Homo sapiens_hsa046620.94662372
43HIF-1 signaling pathway_Homo sapiens_hsa040660.94112040
44PPAR signaling pathway_Homo sapiens_hsa033200.92718297
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92314132
46Tuberculosis_Homo sapiens_hsa051520.91717143
47Insulin resistance_Homo sapiens_hsa049310.91263143
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90271200
49Lysosome_Homo sapiens_hsa041420.90147972
50Complement and coagulation cascades_Homo sapiens_hsa046100.89738363
51Estrogen signaling pathway_Homo sapiens_hsa049150.89324686
52Axon guidance_Homo sapiens_hsa043600.88255421
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87153954
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83721983
55Phagosome_Homo sapiens_hsa041450.82979006
56Insulin signaling pathway_Homo sapiens_hsa049100.82951621
57African trypanosomiasis_Homo sapiens_hsa051430.81788519
58Autoimmune thyroid disease_Homo sapiens_hsa053200.80966730
59Prolactin signaling pathway_Homo sapiens_hsa049170.80214289
60Platelet activation_Homo sapiens_hsa046110.80004666
61Synaptic vesicle cycle_Homo sapiens_hsa047210.79125041
62Chronic myeloid leukemia_Homo sapiens_hsa052200.78469912
63Graft-versus-host disease_Homo sapiens_hsa053320.77592619
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77087696
65Legionellosis_Homo sapiens_hsa051340.77027462
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76668851
67Hepatitis C_Homo sapiens_hsa051600.76535257
68Protein digestion and absorption_Homo sapiens_hsa049740.75298288
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74552354
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71326681
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.70895249
72Antigen processing and presentation_Homo sapiens_hsa046120.70059037
73Ras signaling pathway_Homo sapiens_hsa040140.69265415
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.66839001
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66092681
76Type II diabetes mellitus_Homo sapiens_hsa049300.65190527
77MAPK signaling pathway_Homo sapiens_hsa040100.65042986
78GnRH signaling pathway_Homo sapiens_hsa049120.64840532
79Phenylalanine metabolism_Homo sapiens_hsa003600.64184708
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63723545
81Renal cell carcinoma_Homo sapiens_hsa052110.63712569
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63424293
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62249696
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61823225
85Choline metabolism in cancer_Homo sapiens_hsa052310.59453704
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.58719309
87Type I diabetes mellitus_Homo sapiens_hsa049400.58167956
88Small cell lung cancer_Homo sapiens_hsa052220.56165484
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55442198
90Measles_Homo sapiens_hsa051620.54491928
91Proteoglycans in cancer_Homo sapiens_hsa052050.53402565
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.53251865
93Dilated cardiomyopathy_Homo sapiens_hsa054140.49583332
94Inositol phosphate metabolism_Homo sapiens_hsa005620.49418542
95Pancreatic cancer_Homo sapiens_hsa052120.47890196
96ABC transporters_Homo sapiens_hsa020100.47072000
97Tight junction_Homo sapiens_hsa045300.46736655
98Rheumatoid arthritis_Homo sapiens_hsa053230.46538776
99AMPK signaling pathway_Homo sapiens_hsa041520.46179570
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.45552439

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »