EXOC3L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin transmembrane transport (GO:0035461)7.29022096
2purine nucleobase biosynthetic process (GO:0009113)5.60461195
3mitotic metaphase plate congression (GO:0007080)5.35069786
4monoubiquitinated protein deubiquitination (GO:0035520)5.30222963
5folic acid metabolic process (GO:0046655)5.06338151
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.95498343
7regulation of spindle organization (GO:0090224)4.86612263
8serine family amino acid catabolic process (GO:0009071)4.78231313
9nucleobase biosynthetic process (GO:0046112)4.62899349
10tryptophan catabolic process (GO:0006569)4.40591557
11indole-containing compound catabolic process (GO:0042436)4.40591557
12indolalkylamine catabolic process (GO:0046218)4.40591557
13DNA methylation involved in gamete generation (GO:0043046)4.37304372
14response to pheromone (GO:0019236)4.32380265
15urate metabolic process (GO:0046415)4.23793275
16platelet dense granule organization (GO:0060155)4.18689997
17regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.17822882
18L-fucose catabolic process (GO:0042355)4.15955828
19fucose catabolic process (GO:0019317)4.15955828
20L-fucose metabolic process (GO:0042354)4.15955828
21glycine metabolic process (GO:0006544)4.09478013
22multicellular organism reproduction (GO:0032504)4.04949196
23DNA replication checkpoint (GO:0000076)4.02505930
24pantothenate metabolic process (GO:0015939)4.01685721
25metaphase plate congression (GO:0051310)3.93476205
26regulation of RNA export from nucleus (GO:0046831)3.92155894
27tryptophan metabolic process (GO:0006568)3.89658918
28indolalkylamine metabolic process (GO:0006586)3.88819955
29vitamin transport (GO:0051180)3.83294174
30ribosome assembly (GO:0042255)3.80302959
31positive regulation of chromosome segregation (GO:0051984)3.77986665
32lymph vessel development (GO:0001945)3.76645580
33behavioral response to nicotine (GO:0035095)3.71844282
34regulation of mitotic spindle organization (GO:0060236)3.69634543
35folic acid transport (GO:0015884)3.62853315
36synaptonemal complex assembly (GO:0007130)3.62821948
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.62196777
38biotin metabolic process (GO:0006768)3.60150150
39endothelium development (GO:0003158)3.54089211
40ribosome biogenesis (GO:0042254)3.53544838
41regulation of hippo signaling (GO:0035330)3.50479596
42negative regulation of fibroblast apoptotic process (GO:2000270)3.45160746
43regulation of establishment or maintenance of cell polarity (GO:0032878)3.43088161
44male meiosis (GO:0007140)3.42725428
45regulation of acrosome reaction (GO:0060046)3.40792924
46auditory receptor cell stereocilium organization (GO:0060088)3.39074199
47cellular biogenic amine catabolic process (GO:0042402)3.38337425
48amine catabolic process (GO:0009310)3.38337425
49vascular endothelial growth factor signaling pathway (GO:0038084)3.36348937
50male meiosis I (GO:0007141)3.34541747
51meiosis I (GO:0007127)3.33807875
52regulation of exit from mitosis (GO:0007096)3.32333734
53regulation of endothelial cell differentiation (GO:0045601)3.31701376
54glomerular basement membrane development (GO:0032836)3.31246686
55snRNA transcription (GO:0009301)3.29713308
56regulation of establishment of cell polarity (GO:2000114)3.27478135
57arginine catabolic process (GO:0006527)3.26427630
58kynurenine metabolic process (GO:0070189)3.25879642
59protein localization to chromosome, centromeric region (GO:0071459)3.25810829
60synaptonemal complex organization (GO:0070193)3.24393091
61serine family amino acid metabolic process (GO:0009069)3.23927733
62regulation of nucleobase-containing compound transport (GO:0032239)3.22846136
63retinal cone cell development (GO:0046549)3.21637628
64ovulation from ovarian follicle (GO:0001542)3.18158191
65glomerular visceral epithelial cell development (GO:0072015)3.18117600
66inner cell mass cell proliferation (GO:0001833)3.15420679
67positive regulation of defense response to virus by host (GO:0002230)3.13133859
68S-adenosylmethionine metabolic process (GO:0046500)3.11294876
69blood vessel maturation (GO:0001955)3.10720624
70modified amino acid transport (GO:0072337)3.09756189
71lung-associated mesenchyme development (GO:0060484)3.08730533
72regulation of meiosis I (GO:0060631)3.08615910
73water-soluble vitamin biosynthetic process (GO:0042364)3.08472014
74regulation of female gonad development (GO:2000194)3.05776523
75regulation of chromosome segregation (GO:0051983)3.05582077
76detection of light stimulus involved in visual perception (GO:0050908)3.04694635
77detection of light stimulus involved in sensory perception (GO:0050962)3.04694635
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04054804
79protein localization to kinetochore (GO:0034501)3.03921860
80thrombin receptor signaling pathway (GO:0070493)3.03883827
81mitotic chromosome condensation (GO:0007076)3.00718941
82regulation of transcription from RNA polymerase I promoter (GO:0006356)2.98371815
83peptidyl-threonine dephosphorylation (GO:0035970)2.97461901
84oocyte maturation (GO:0001556)2.95778912
85photoreceptor cell maintenance (GO:0045494)2.95202591
86positive regulation of protein kinase C signaling (GO:0090037)2.94731204
87positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93301887
88positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93301887
89positive regulation of mitotic sister chromatid separation (GO:1901970)2.93301887
90positive regulation of prostaglandin secretion (GO:0032308)2.92982091
91DNA damage response, signal transduction resulting in transcription (GO:0042772)2.92774600
92synapsis (GO:0007129)2.91550988
93pyrimidine-containing compound transmembrane transport (GO:0072531)2.91174110
94protein localization to chromosome (GO:0034502)2.90851345
95transcription from mitochondrial promoter (GO:0006390)2.89375273
96regulation of G0 to G1 transition (GO:0070316)2.88538733
97cofactor transport (GO:0051181)2.88384752
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87450063
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87450063
100aggressive behavior (GO:0002118)2.86655670
101negative regulation of telomere maintenance (GO:0032205)2.83901723
102epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81896536
103regulation of sister chromatid cohesion (GO:0007063)2.81316312
104protein K6-linked ubiquitination (GO:0085020)2.81147685
105axoneme assembly (GO:0035082)2.80173850
106mitotic sister chromatid segregation (GO:0000070)2.78617399
107benzene-containing compound metabolic process (GO:0042537)2.76755096
108regulation of cilium movement (GO:0003352)2.76673225
109intestinal epithelial cell development (GO:0060576)2.76325128
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.75502830
111termination of RNA polymerase III transcription (GO:0006386)2.75502830
112positive regulation of fatty acid transport (GO:2000193)2.75448255
113cysteine metabolic process (GO:0006534)2.75383153
114negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.74740918
115NAD biosynthetic process (GO:0009435)2.71696236
116regulation of memory T cell differentiation (GO:0043380)2.70641916
117behavioral response to ethanol (GO:0048149)2.70429196
118histone H2A monoubiquitination (GO:0035518)2.69322018
119protein-cofactor linkage (GO:0018065)2.68980557
120establishment of chromosome localization (GO:0051303)2.68445028
121blastocyst development (GO:0001824)2.66666837
122glomerular epithelial cell development (GO:0072310)2.66261764
123mitotic nuclear envelope disassembly (GO:0007077)2.65514793
124spindle checkpoint (GO:0031577)2.64320857
125mitotic G1 DNA damage checkpoint (GO:0031571)2.64153773
126aromatic amino acid family catabolic process (GO:0009074)2.63748671
127cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.63709062
128piRNA metabolic process (GO:0034587)2.63467362
129positive regulation of steroid hormone secretion (GO:2000833)2.62494838
130positive regulation of T-helper 1 type immune response (GO:0002827)2.60866479
131DNA deamination (GO:0045006)2.60773753
132respiratory chain complex IV assembly (GO:0008535)2.60408192
133photoreceptor cell development (GO:0042461)2.59046382
134arginine metabolic process (GO:0006525)2.58820365
135negative regulation of endothelial cell apoptotic process (GO:2000352)2.58190878
136rRNA modification (GO:0000154)2.58102687
137positive regulation of icosanoid secretion (GO:0032305)2.57679426
138preassembly of GPI anchor in ER membrane (GO:0016254)2.57361786
139G1 DNA damage checkpoint (GO:0044783)2.56754997
140phosphatidylinositol acyl-chain remodeling (GO:0036149)2.56176323
141regulation of bile acid biosynthetic process (GO:0070857)2.55998993
142inositol phosphate catabolic process (GO:0071545)2.54895284
143tachykinin receptor signaling pathway (GO:0007217)2.53741569
144mannosylation (GO:0097502)2.53231326
145autophagic vacuole assembly (GO:0000045)2.53022478
146negative regulation of macrophage differentiation (GO:0045650)2.52411981
147cellular response to exogenous dsRNA (GO:0071360)2.51748350
148seminiferous tubule development (GO:0072520)2.50710995
149DNA alkylation (GO:0006305)2.50329999
150DNA methylation (GO:0006306)2.50329999
151indole-containing compound metabolic process (GO:0042430)2.50058778
152rRNA catabolic process (GO:0016075)2.48899739
153nuclear envelope disassembly (GO:0051081)2.47881138
154membrane disassembly (GO:0030397)2.47881138
155fibroblast migration (GO:0010761)2.47700454
156polyamine biosynthetic process (GO:0006596)2.46286695
157negative regulation of chromosome segregation (GO:0051985)2.45518305
158nuclear pore organization (GO:0006999)2.45375873
159UDP-N-acetylglucosamine metabolic process (GO:0006047)2.44694219
160mitotic spindle checkpoint (GO:0071174)2.44477348
161response to hydroperoxide (GO:0033194)2.44432089
162cytochrome complex assembly (GO:0017004)2.43645183
163surfactant homeostasis (GO:0043129)2.43247432
164positive regulation of endothelial cell differentiation (GO:0045603)2.43204914
165negative regulation of transcription regulatory region DNA binding (GO:2000678)2.42635294
166regulation of T-helper 1 type immune response (GO:0002825)2.42547412
167cell migration involved in sprouting angiogenesis (GO:0002042)2.42301496
168positive regulation of triglyceride biosynthetic process (GO:0010867)2.41483555
169gene silencing by RNA (GO:0031047)2.41344765
170replication fork processing (GO:0031297)2.40111616
171reproduction (GO:0000003)2.39530899
172serine family amino acid biosynthetic process (GO:0009070)2.39513643
173heparin biosynthetic process (GO:0030210)2.39379595
174heparin metabolic process (GO:0030202)2.39379595
175protein complex biogenesis (GO:0070271)2.39217085
176phosphatidylserine acyl-chain remodeling (GO:0036150)2.34858735
177DNA modification (GO:0006304)2.34270316
178DNA methylation or demethylation (GO:0044728)2.34198115
179RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.33712093
180methionine biosynthetic process (GO:0009086)2.33525818
181phosphorylated carbohydrate dephosphorylation (GO:0046838)2.33392157
182inositol phosphate dephosphorylation (GO:0046855)2.33392157
183reciprocal DNA recombination (GO:0035825)2.32368269
184reciprocal meiotic recombination (GO:0007131)2.32368269
185cAMP catabolic process (GO:0006198)2.32112380
186short-chain fatty acid metabolic process (GO:0046459)2.30581119
187sulfation (GO:0051923)2.30452301
188lymphangiogenesis (GO:0001946)2.28650446
189xenobiotic catabolic process (GO:0042178)2.28561824
190centriole replication (GO:0007099)2.28279707
191negative regulation of mast cell activation (GO:0033004)2.28198371
192eye photoreceptor cell development (GO:0042462)2.27739484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.78619204
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.75765038
3ZNF274_21170338_ChIP-Seq_K562_Hela4.51356254
4VDR_22108803_ChIP-Seq_LS180_Human4.13860869
5E2F7_22180533_ChIP-Seq_HELA_Human4.05988422
6ZNF263_19887448_ChIP-Seq_K562_Human3.87281499
7AR_21909140_ChIP-Seq_LNCAP_Human3.44284107
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.10110359
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.01129621
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83076658
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66474108
12IGF1R_20145208_ChIP-Seq_DFB_Human2.64537449
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.62120657
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53527753
15GBX2_23144817_ChIP-Seq_PC3_Human2.44298323
16EZH2_22144423_ChIP-Seq_EOC_Human2.41765929
17CLOCK_20551151_ChIP-Seq_293T_Human2.24883422
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.24865261
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.22201650
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20992670
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14909491
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14171638
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06286395
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96404592
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89923818
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88999750
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.87517364
28BCAT_22108803_ChIP-Seq_LS180_Human1.86814445
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86391410
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86328702
31ER_23166858_ChIP-Seq_MCF-7_Human1.85304679
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83760193
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83524778
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83190101
35P300_19829295_ChIP-Seq_ESCs_Human1.79179496
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.77057054
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76986191
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.75540417
39KLF4_18555785_ChIP-Seq_MESCs_Mouse1.73581745
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.73260701
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72685495
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69061099
43EWS_26573619_Chip-Seq_HEK293_Human1.66312819
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65728465
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64824671
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.64590497
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63748216
48TP53_22573176_ChIP-Seq_HFKS_Human1.63322106
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.63310000
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62736070
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57964571
52FUS_26573619_Chip-Seq_HEK293_Human1.56290607
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56080927
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55642228
55* CBP_20019798_ChIP-Seq_JUKART_Human1.55611227
56* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55611227
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55584355
58SCL_19346495_ChIP-Seq_HPC-7_Human1.54145978
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.52908367
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52703751
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52124947
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52070157
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51048516
64AR_20517297_ChIP-Seq_VCAP_Human1.49312646
65* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48678830
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48463969
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48343672
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.47876783
69TCF4_22108803_ChIP-Seq_LS180_Human1.47429002
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46289600
71SOX2_19829295_ChIP-Seq_ESCs_Human1.46173850
72NANOG_19829295_ChIP-Seq_ESCs_Human1.46173850
73TCF4_23295773_ChIP-Seq_U87_Human1.46080097
74MYC_18940864_ChIP-ChIP_HL60_Human1.45696667
75XRN2_22483619_ChIP-Seq_HELA_Human1.43500817
76KDM5A_27292631_Chip-Seq_BREAST_Human1.42405427
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42291012
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.42113195
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41343821
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41343821
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41343821
82STAT3_23295773_ChIP-Seq_U87_Human1.40911390
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40518832
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39370623
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39357376
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.39242962
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39242962
88GABP_19822575_ChIP-Seq_HepG2_Human1.38930809
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.38788436
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.36602117
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.34416414
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33502028
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32906874
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.30827392
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30670076
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30370056
97TAF15_26573619_Chip-Seq_HEK293_Human1.30174878
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29445889
99SMAD4_21799915_ChIP-Seq_A2780_Human1.29262771
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.29062754
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28917767
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28659524
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27848467
104GATA3_26560356_Chip-Seq_TH2_Human1.27690883
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.27257835
106CDX2_22108803_ChIP-Seq_LS180_Human1.27146531
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26643368
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26148207
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25443252
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24153334
111NANOG_20526341_ChIP-Seq_ESCs_Human1.23937723
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23680070
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23565303
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23158501
115AR_25329375_ChIP-Seq_VCAP_Human1.23059421
116ESR1_21235772_ChIP-Seq_MCF-7_Human1.22320635
117HOXB7_26014856_ChIP-Seq_BT474_Human1.21954617
118MYC_22102868_ChIP-Seq_BL_Human1.21601883
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21356772
120IRF1_19129219_ChIP-ChIP_H3396_Human1.20728409
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19966644
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19966644
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.19714861
124ESR2_21235772_ChIP-Seq_MCF-7_Human1.19578087
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19018631
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18940996
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.18387963
128* NCOR_22424771_ChIP-Seq_293T_Human1.17905835
129FOXH1_21741376_ChIP-Seq_EPCs_Human1.17337510
130ATF3_27146783_Chip-Seq_COLON_Human1.15609796
131TAF2_19829295_ChIP-Seq_ESCs_Human1.15169461
132NCOR1_26117541_ChIP-Seq_K562_Human1.15000827
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14653064
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14192180
135MYC_19829295_ChIP-Seq_ESCs_Human1.13890158
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13764236
137SRF_21415370_ChIP-Seq_HL-1_Mouse1.12956711
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11707522
139ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11027223
140SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11025199
141ELK1_19687146_ChIP-ChIP_HELA_Human1.10869034
142PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10726581
143AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09980790
144RUNX2_22187159_ChIP-Seq_PCA_Human1.09255458
145PRDM14_20953172_ChIP-Seq_ESCs_Human1.09097412
146GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08080665
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07842913
148KAP1_27257070_Chip-Seq_ESCs_Mouse1.07582168
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07209658
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05532398
151SMAD4_21741376_ChIP-Seq_EPCs_Human1.05453698
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05420872
153BP1_19119308_ChIP-ChIP_Hs578T_Human1.05288055
154TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05026043
155NFE2_27457419_Chip-Seq_LIVER_Mouse1.04706956
156EGR1_19374776_ChIP-ChIP_THP-1_Human1.04479862
157E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04474230
158STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04204576
159SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03763216
160UBF1/2_26484160_Chip-Seq_HMECs_Human1.03107577
161PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02958618
162GABP_17652178_ChIP-ChIP_JURKAT_Human1.02905663
163EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02616531
164PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02550734
165TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01775123
166PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00785642
167CRX_20693478_ChIP-Seq_RETINA_Mouse0.99939956
168ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99880659
169KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99174765
170FLI1_21867929_ChIP-Seq_TH2_Mouse0.98703090
171EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97772068
172STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97659995
173TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95902376
174MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95583773
175VDR_23849224_ChIP-Seq_CD4+_Human0.94094103
176NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93831570
177NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91977423
178SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90727952
179KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90327619
180RACK7_27058665_Chip-Seq_MCF-7_Human0.88877173
181BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88724892
182SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88287025
183TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86987706
184RARB_24833708_ChIP-Seq_LIVER_Mouse0.86329556
185KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86107584
186P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85313076
187SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85019519
188SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84493733
189E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84451566
190SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83704140
191POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82158015
192FOXP3_21729870_ChIP-Seq_TREG_Human0.82049361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.34833605
2MP0000372_irregular_coat_pigmentation3.29515689
3MP0003693_abnormal_embryo_hatching3.24668798
4MP0005451_abnormal_body_composition2.99481990
5MP0005365_abnormal_bile_salt2.75047123
6MP0003111_abnormal_nucleus_morphology2.70104446
7MP0005360_urolithiasis2.65545822
8MP0002139_abnormal_hepatobiliary_system2.64592957
9MP0003718_maternal_effect2.62163617
10MP0005167_abnormal_blood-brain_barrier2.60148720
11MP0003828_pulmonary_edema2.36192360
12MP0001879_abnormal_lymphatic_vessel2.33552465
13MP0008995_early_reproductive_senescence2.32250747
14MP0005551_abnormal_eye_electrophysiolog2.27793014
15MP0004147_increased_porphyrin_level2.27055129
16MP0001986_abnormal_taste_sensitivity2.26755330
17MP0001661_extended_life_span2.22276760
18MP0004272_abnormal_basement_membrane2.18360582
19MP0009840_abnormal_foam_cell2.16126314
20MP0003077_abnormal_cell_cycle2.16027546
21MP0005085_abnormal_gallbladder_physiolo2.06784638
22MP0005646_abnormal_pituitary_gland2.02005416
23MP0004957_abnormal_blastocyst_morpholog2.01646097
24MP0008057_abnormal_DNA_replication1.97390362
25MP0002876_abnormal_thyroid_physiology1.97117140
26MP0001501_abnormal_sleep_pattern1.94726516
27MP0005377_hearing/vestibular/ear_phenot1.90537653
28MP0003878_abnormal_ear_physiology1.90537653
29MP0003950_abnormal_plasma_membrane1.90076104
30MP0001730_embryonic_growth_arrest1.89264608
31MP0008877_abnormal_DNA_methylation1.85887530
32MP0008872_abnormal_physiological_respon1.81803245
33MP0003136_yellow_coat_color1.79914151
34MP0001968_abnormal_touch/_nociception1.78792423
35MP0010094_abnormal_chromosome_stability1.78656027
36MP0005410_abnormal_fertilization1.77037989
37MP0004084_abnormal_cardiac_muscle1.74345735
38MP0008007_abnormal_cellular_replicative1.73922999
39MP0005174_abnormal_tail_pigmentation1.73437891
40MP0009278_abnormal_bone_marrow1.71592081
41MP0005253_abnormal_eye_physiology1.69095659
42MP0001672_abnormal_embryogenesis/_devel1.68794763
43MP0005380_embryogenesis_phenotype1.68794763
44MP0005084_abnormal_gallbladder_morpholo1.68234401
45MP0003786_premature_aging1.60008809
46MP0003984_embryonic_growth_retardation1.56305811
47MP0004043_abnormal_pH_regulation1.56158244
48MP0005332_abnormal_amino_acid1.56006275
49MP0001545_abnormal_hematopoietic_system1.55820365
50MP0005397_hematopoietic_system_phenotyp1.55820365
51MP0006072_abnormal_retinal_apoptosis1.55163160
52MP0004019_abnormal_vitamin_homeostasis1.53673443
53MP0010307_abnormal_tumor_latency1.52545382
54MP0002088_abnormal_embryonic_growth/wei1.51942823
55MP0004484_altered_response_of1.51007876
56MP0003123_paternal_imprinting1.50108152
57MP0008775_abnormal_heart_ventricle1.48545604
58MP0005075_abnormal_melanosome_morpholog1.48014039
59MP0005647_abnormal_sex_gland1.46796696
60MP0002086_abnormal_extraembryonic_tissu1.45352800
61MP0001756_abnormal_urination1.41305540
62MP0006138_congestive_heart_failure1.37050564
63MP0006292_abnormal_olfactory_placode1.36960847
64MP0000013_abnormal_adipose_tissue1.36683749
65MP0003252_abnormal_bile_duct1.34952210
66MP0003646_muscle_fatigue1.33261600
67MP0003705_abnormal_hypodermis_morpholog1.31950119
68MP0009333_abnormal_splenocyte_physiolog1.31840890
69MP0002396_abnormal_hematopoietic_system1.31453327
70MP0001697_abnormal_embryo_size1.30593600
71MP0001984_abnormal_olfaction1.28709490
72MP0001764_abnormal_homeostasis1.27987924
73MP0002210_abnormal_sex_determination1.27195552
74MP0000015_abnormal_ear_pigmentation1.27144264
75MP0003787_abnormal_imprinting1.26396704
76MP0006276_abnormal_autonomic_nervous1.23574483
77MP0009643_abnormal_urine_homeostasis1.22187947
78MP0005395_other_phenotype1.21504524
79MP0008875_abnormal_xenobiotic_pharmacok1.20816879
80MP0000230_abnormal_systemic_arterial1.19945895
81MP0002138_abnormal_hepatobiliary_system1.19118674
82MP0000350_abnormal_cell_proliferation1.17503485
83MP0001849_ear_inflammation1.15347112
84MP0004808_abnormal_hematopoietic_stem1.15011568
85MP0008260_abnormal_autophagy1.14855159
86MP0001929_abnormal_gametogenesis1.14458568
87MP0004185_abnormal_adipocyte_glucose1.14444514
88MP0003221_abnormal_cardiomyocyte_apopto1.13685432
89MP0001145_abnormal_male_reproductive1.11784722
90MP0009697_abnormal_copulation1.11174961
91MP0000427_abnormal_hair_cycle1.10311931
92MP0002148_abnormal_hypersensitivity_rea1.08698805
93MP0000653_abnormal_sex_gland1.08388633
94MP0002080_prenatal_lethality1.07218257
95MP0004215_abnormal_myocardial_fiber1.06197716
96MP0002084_abnormal_developmental_patter1.05648168
97MP0002085_abnormal_embryonic_tissue1.05242627
98MP0000609_abnormal_liver_physiology1.05186000
99MP0008789_abnormal_olfactory_epithelium1.04800515
100MP0009764_decreased_sensitivity_to1.04485964
101MP0004145_abnormal_muscle_electrophysio1.03675405
102MP0005645_abnormal_hypothalamus_physiol1.01746655
103MP0002735_abnormal_chemical_nociception1.00060134
104MP0003315_abnormal_perineum_morphology0.99444030
105MP0005389_reproductive_system_phenotype0.98789500
106MP0005187_abnormal_penis_morphology0.97973396
107MP0001486_abnormal_startle_reflex0.97762428
108MP0008058_abnormal_DNA_repair0.96968399
109MP0000767_abnormal_smooth_muscle0.95289232
110MP0002736_abnormal_nociception_after0.94660725
111MP0002127_abnormal_cardiovascular_syste0.94612780
112MP0005367_renal/urinary_system_phenotyp0.93847159
113MP0000516_abnormal_urinary_system0.93847159
114MP0001119_abnormal_female_reproductive0.91417675
115MP0003195_calcinosis0.90572458
116MP0009672_abnormal_birth_weight0.89420357
117MP0002136_abnormal_kidney_physiology0.89408782
118MP0005319_abnormal_enzyme/_coenzyme0.88579089
119MP0005408_hypopigmentation0.88246729
120MP0002837_dystrophic_cardiac_calcinosis0.86429477
121MP0003806_abnormal_nucleotide_metabolis0.86404734
122MP0005464_abnormal_platelet_physiology0.85335265
123MP0000537_abnormal_urethra_morphology0.85302515
124MP0004142_abnormal_muscle_tone0.85088812
125MP0010329_abnormal_lipoprotein_level0.84766370
126MP0004264_abnormal_extraembryonic_tissu0.84393743
127MP0003699_abnormal_female_reproductive0.82761985
128MP0001485_abnormal_pinna_reflex0.82139703
129MP0000631_abnormal_neuroendocrine_gland0.81964461
130MP0002928_abnormal_bile_duct0.81492295
131MP0008932_abnormal_embryonic_tissue0.81062664
132MP0002254_reproductive_system_inflammat0.80349047
133MP0004381_abnormal_hair_follicle0.80098246
134MP0003935_abnormal_craniofacial_develop0.79961375
135MP0005379_endocrine/exocrine_gland_phen0.79798819
136MP0001919_abnormal_reproductive_system0.79447611
137MP0005595_abnormal_vascular_smooth0.79441882
138MP0003724_increased_susceptibility_to0.79128857
139MP0000750_abnormal_muscle_regeneration0.78930822
140MP0009745_abnormal_behavioral_response0.78240741
141MP0003567_abnormal_fetal_cardiomyocyte0.78119048
142MP0000465_gastrointestinal_hemorrhage0.76964249
143MP0003698_abnormal_male_reproductive0.76841805
144MP0000598_abnormal_liver_morphology0.76779246
145MP0002925_abnormal_cardiovascular_devel0.76252886
146MP0003943_abnormal_hepatobiliary_system0.75764430
147MP0002653_abnormal_ependyma_morphology0.75714632
148MP0001727_abnormal_embryo_implantation0.75541751
149MP0001614_abnormal_blood_vessel0.75196529
150MP0003303_peritoneal_inflammation0.74227193
151MP0002160_abnormal_reproductive_system0.74170908
152MP0002163_abnormal_gland_morphology0.74053411
153MP0001915_intracranial_hemorrhage0.74046863
154MP0001784_abnormal_fluid_regulation0.73839745
155MP0003191_abnormal_cellular_cholesterol0.73049824
156MP0002933_joint_inflammation0.71899429
157MP0002102_abnormal_ear_morphology0.70031149
158MP0004885_abnormal_endolymph0.68921992
159MP0004036_abnormal_muscle_relaxation0.68623743
160MP0005083_abnormal_biliary_tract0.67828916
161MP0002095_abnormal_skin_pigmentation0.66732316
162MP0009785_altered_susceptibility_to0.66682847

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.95062375
2Polycythemia (HP:0001901)5.65379700
3Hyperglycinemia (HP:0002154)5.26540978
4Hyperglycinuria (HP:0003108)4.80381314
5Male infertility (HP:0003251)4.77354623
6Breast hypoplasia (HP:0003187)4.33585585
7Capillary hemangiomas (HP:0005306)4.24638429
8Pancreatic cysts (HP:0001737)4.14422827
9Attenuation of retinal blood vessels (HP:0007843)3.96112464
10Congenital stationary night blindness (HP:0007642)3.90256616
11Abnormality of serine family amino acid metabolism (HP:0010894)3.82760231
12Abnormality of glycine metabolism (HP:0010895)3.82760231
13Pancreatic fibrosis (HP:0100732)3.81740566
14Birth length less than 3rd percentile (HP:0003561)3.67532972
15Impulsivity (HP:0100710)3.66054826
16Atrioventricular block (HP:0001678)3.56306401
17Decreased central vision (HP:0007663)3.55930210
18Abnormal rod and cone electroretinograms (HP:0008323)3.45521640
19True hermaphroditism (HP:0010459)3.42491783
20Hyperuricemia (HP:0002149)3.36209683
21Increased purine levels (HP:0004368)3.36209683
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.31001800
23Abnormality of the renal cortex (HP:0011035)3.26110498
24Azoospermia (HP:0000027)3.25787400
25Conjunctival telangiectasia (HP:0000524)3.25471120
26Facial hemangioma (HP:0000329)3.23223081
27Abnormality of midbrain morphology (HP:0002418)3.23032222
28Molar tooth sign on MRI (HP:0002419)3.23032222
29Type II lissencephaly (HP:0007260)3.18129339
30Deep venous thrombosis (HP:0002625)3.16846481
31Abnormal spermatogenesis (HP:0008669)3.16184700
32Nephronophthisis (HP:0000090)3.12911295
33Abnormality of the renal medulla (HP:0100957)3.03586379
34Muscle fiber splitting (HP:0003555)2.99108619
35Carpal bone hypoplasia (HP:0001498)2.98619648
36Abnormality of the intrinsic pathway (HP:0010989)2.89666490
37Stomach cancer (HP:0012126)2.88122560
38Tetraplegia (HP:0002445)2.85395739
39Progressive muscle weakness (HP:0003323)2.84230278
40Hematochezia (HP:0002573)2.82373681
41Abolished electroretinogram (ERG) (HP:0000550)2.77363720
42Renal cortical cysts (HP:0000803)2.71589906
43Multiple enchondromatosis (HP:0005701)2.66134287
44Esophageal varix (HP:0002040)2.64216203
45Patellar aplasia (HP:0006443)2.62715793
46Abnormality of purine metabolism (HP:0004352)2.60961068
47Aplasia/Hypoplasia of the patella (HP:0006498)2.57856294
48Cystic liver disease (HP:0006706)2.54986203
49Secondary amenorrhea (HP:0000869)2.54210367
50Abnormality of serum amino acid levels (HP:0003112)2.54034511
51Entropion (HP:0000621)2.53115204
52Keratoconus (HP:0000563)2.52835377
53Increased corneal curvature (HP:0100692)2.52835377
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.52354500
55Shawl scrotum (HP:0000049)2.51228959
56Areflexia of lower limbs (HP:0002522)2.50838405
57Pustule (HP:0200039)2.50378534
58Increased circulating renin level (HP:0000848)2.46605055
59Tetany (HP:0001281)2.46242179
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44213444
61Hypokalemic alkalosis (HP:0001949)2.44145942
62Abnormality of the hepatic vasculature (HP:0006707)2.43384436
63Hyperlipoproteinemia (HP:0010980)2.43212249
64Stomatitis (HP:0010280)2.40955746
65Abnormality of the vasculature of the conjunctiva (HP:0008054)2.39724938
66Mesangial abnormality (HP:0001966)2.37868006
67Methylmalonic acidemia (HP:0002912)2.37163890
68Medial flaring of the eyebrow (HP:0010747)2.37095129
69Polydipsia (HP:0001959)2.37077560
70Abnormal drinking behavior (HP:0030082)2.37077560
71Hypoplasia of the fovea (HP:0007750)2.37003827
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.37003827
73Focal segmental glomerulosclerosis (HP:0000097)2.35518612
74Gonadal dysgenesis (HP:0000133)2.35458559
75Hypothermia (HP:0002045)2.33926496
76Abnormality of male internal genitalia (HP:0000022)2.32872000
77Congenital hepatic fibrosis (HP:0002612)2.30859994
78Rough bone trabeculation (HP:0100670)2.28066731
79Pendular nystagmus (HP:0012043)2.22475383
80Hyperventilation (HP:0002883)2.22131116
81Chronic hepatic failure (HP:0100626)2.21821749
82Cerebral hemorrhage (HP:0001342)2.20539667
83Abnormality of macular pigmentation (HP:0008002)2.20479240
84Abnormality of chloride homeostasis (HP:0011422)2.20135125
85Methylmalonic aciduria (HP:0012120)2.19996463
86Abnormality of the fovea (HP:0000493)2.19688679
87Thyroiditis (HP:0100646)2.18504234
88Metaphyseal cupping (HP:0003021)2.16159824
89Polyuria (HP:0000103)2.12958901
90Abnormality of nucleobase metabolism (HP:0010932)2.12951822
91Cerebellar dysplasia (HP:0007033)2.11783557
92Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11336301
93Tubular atrophy (HP:0000092)2.11012230
94Bony spicule pigmentary retinopathy (HP:0007737)2.10469151
95Infertility (HP:0000789)2.09937348
96Gaze-evoked nystagmus (HP:0000640)2.08839869
97Abnormal biliary tract physiology (HP:0012439)2.08569189
98Bile duct proliferation (HP:0001408)2.08569189
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.08501784
100Absent/shortened dynein arms (HP:0200106)2.08501784
101Metaphyseal dysplasia (HP:0100255)2.08485558
102Segmental peripheral demyelination/remyelination (HP:0003481)2.08007039
103Spontaneous hematomas (HP:0007420)2.06204178
104Abnormality of the prostate (HP:0008775)2.05658192
105Delayed CNS myelination (HP:0002188)2.05240608
106Visceral angiomatosis (HP:0100761)2.04823532
107Chondrocalcinosis (HP:0000934)2.03174791
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02573521
109Glomerulonephritis (HP:0000099)2.02095863
110Abnormality of the lower motor neuron (HP:0002366)2.01863742
111Acute encephalopathy (HP:0006846)2.01328369
112Abnormal platelet function (HP:0011869)2.01292908
113Impaired platelet aggregation (HP:0003540)2.01292908
114Difficulty climbing stairs (HP:0003551)2.01012860
115Congenital sensorineural hearing impairment (HP:0008527)2.00941697
116Hypoplasia of the uterus (HP:0000013)2.00801996
117Abnormality of the nasal mucosa (HP:0000433)2.00763790
118Hemangiomatosis (HP:0007461)2.00625532
119Myocardial infarction (HP:0001658)2.00289650
120Heart block (HP:0012722)1.99195960
121Oligodactyly (HP:0012165)1.96775712
122Nephritis (HP:0000123)1.95760302
123Sclerocornea (HP:0000647)1.95542547
124Death in infancy (HP:0001522)1.95150622
125Fatigue (HP:0012378)1.94678529
126Ankle contracture (HP:0006466)1.94506327
127Male pseudohermaphroditism (HP:0000037)1.93890736
128Muscle fibrillation (HP:0010546)1.93826271
129Cerebral palsy (HP:0100021)1.93647760
130Delayed epiphyseal ossification (HP:0002663)1.92576770
131Premature ovarian failure (HP:0008209)1.92171093
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.91962782
133Global brain atrophy (HP:0002283)1.91392433
134Enlarged penis (HP:0000040)1.91341149
135Abnormality of the pons (HP:0007361)1.91018426
136Concave nail (HP:0001598)1.90783781
137Spontaneous abortion (HP:0005268)1.89310155
138Xanthomatosis (HP:0000991)1.88655565
139Lymphangioma (HP:0100764)1.88201250
140Aplasia/hypoplasia of the uterus (HP:0008684)1.87862744
141Occipital encephalocele (HP:0002085)1.87585085
142Abnormal delayed hypersensitivity skin test (HP:0002963)1.87251077
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.86387956
144Glomerulosclerosis (HP:0000096)1.86112256
145Acute necrotizing encephalopathy (HP:0006965)1.86052040
146Aplasia/Hypoplasia of the macula (HP:0008059)1.85904251
147Constricted visual fields (HP:0001133)1.85707289
148Progressive macrocephaly (HP:0004481)1.85046350
149Optic disc pallor (HP:0000543)1.84608367
1503-Methylglutaconic aciduria (HP:0003535)1.83503870
151Bundle branch block (HP:0011710)1.82746500
152Increased CSF lactate (HP:0002490)1.82710562
153Abnormal atrioventricular conduction (HP:0005150)1.82222263
154Macular degeneration (HP:0000608)1.82147184
155Cerebral hypomyelination (HP:0006808)1.82095135
156Bulbous nose (HP:0000414)1.81834595
157Decreased circulating renin level (HP:0003351)1.81327758
158Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78868122
159Hyperammonemia (HP:0001987)1.78507958
160Abnormality of Sharpey fibers (HP:0100685)1.77996139
161Absent hand (HP:0004050)1.77784661
162Hypoplasia of the pons (HP:0012110)1.77710925
163Ureteral duplication (HP:0000073)1.77684461
164Mitochondrial inheritance (HP:0001427)1.76907046
165Abnormality of eosinophils (HP:0001879)1.75797307
166Abnormal cartilage morphology (HP:0002763)1.75779958
167Prostate neoplasm (HP:0100787)1.75167370
168Thoracolumbar scoliosis (HP:0002944)1.75025127
169Photophobia (HP:0000613)1.74493629
170Confusion (HP:0001289)1.74406880
171Osteolytic defects of the phalanges of the hand (HP:0009771)1.74168057
172Osteolytic defects of the hand bones (HP:0009699)1.74168057
173Albinism (HP:0001022)1.74160295
174Disproportionate short-trunk short stature (HP:0003521)1.74048257
175Anencephaly (HP:0002323)1.74047900
176Short tibia (HP:0005736)1.73293181
177Aplasia/Hypoplasia of the spleen (HP:0010451)1.73002782
178Severe visual impairment (HP:0001141)1.72415327
179Prominent nose (HP:0000448)1.71972068
180Aplasia/Hypoplasia affecting the retina (HP:0008061)1.71633604
181Intrahepatic cholestasis (HP:0001406)1.71212960
182Hyperglycemia (HP:0003074)1.71169557
183Hypoplastic iliac wings (HP:0002866)1.71048452
184Abnormal urine output (HP:0012590)1.70412368
185Hypomagnesemia (HP:0002917)1.70099331
186Oral leukoplakia (HP:0002745)1.70097869
187Lissencephaly (HP:0001339)1.68052953
188Abnormality of the heme biosynthetic pathway (HP:0010472)1.67758265
189IgG deficiency (HP:0004315)1.67719844
190Abnormality of T cell physiology (HP:0011840)1.67196859
191Supernumerary spleens (HP:0009799)1.66631367
192Dyschromatopsia (HP:0007641)1.66415949
193Congenital primary aphakia (HP:0007707)1.66394808
194Postaxial foot polydactyly (HP:0001830)1.65780269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.14028724
2FRK5.05472031
3TAOK34.04119061
4KDR3.99375037
5LATS23.79795346
6BUB13.75863062
7NEK23.40117712
8NUAK13.27988025
9BMPR1B3.12676473
10LATS13.11371732
11ADRBK22.62031561
12WEE12.50949052
13STK38L2.40840762
14STK32.37182990
15ZAK2.35530951
16WNK42.16489204
17DYRK32.15535825
18AKT32.08817654
19BRSK22.06955826
20MAP4K21.90964821
21PLK41.83779800
22TGFBR21.83445381
23TLK11.80967474
24EIF2AK31.80698363
25ACVR1B1.79492109
26INSRR1.59416840
27OXSR11.54560755
28MST41.45093624
29WNK31.43971487
30CDK71.43381516
31FER1.42276401
32TEC1.38588247
33TXK1.37557902
34PLK11.37556488
35CDK121.35218731
36CDK41.34759383
37TGFBR11.33358135
38IRAK11.32982738
39MKNK21.32534903
40TTK1.31515180
41STK391.27120552
42CDC71.25635548
43TRIB31.24879337
44NME21.24548641
45MAPK131.22318863
46TRPM71.22193298
47IKBKB1.21186942
48CHEK21.17034390
49ERN11.15866850
50PDK21.15323218
51TYRO31.14060653
52DAPK21.09499804
53MAP3K61.08492830
54PINK11.07339294
55TNK21.05864870
56MUSK1.05789017
57EPHB21.05099227
58DYRK21.01796587
59CSNK1G11.00572687
60KIT0.97610176
61FGFR40.96720026
62AURKB0.96046961
63FLT30.95619668
64ITK0.91230460
65BRSK10.90034092
66MAP2K30.88301545
67MAPKAPK30.86653119
68PDGFRA0.86502176
69ABL20.86353263
70BCKDK0.86272358
71MAP3K30.85481913
72PDK40.85215161
73PDK30.85215161
74FES0.85079326
75PRKD30.84083557
76TAOK10.83240516
77PAK30.82931158
78SRPK10.82698051
79RPS6KA40.81225889
80ADRBK10.80629993
81PRKAA10.80074357
82ERBB30.77467426
83GRK10.77465357
84EIF2AK10.77203564
85KSR20.76634703
86NTRK30.76035848
87MARK30.74799655
88PLK30.73668214
89PAK40.73544044
90TNIK0.73294550
91FGFR20.72836995
92CDK80.71575038
93PRKCQ0.71151171
94PRKCI0.70596578
95MAP2K20.68599622
96PLK20.68331773
97PRKCE0.67949665
98CHEK10.66670866
99MTOR0.66639498
100VRK10.66393105
101MAP3K40.66263671
102MAP2K60.66050603
103MKNK10.65351089
104PIK3CG0.65310041
105TBK10.64083816
106STK380.63592995
107MAP3K70.62932035
108PAK20.61384896
109MAP4K10.61217583
110TRIM280.60253426
111JAK30.59923882
112PAK60.59820069
113CSNK1A1L0.57758672
114MAP3K130.57719873
115GSK3A0.55558552
116STK100.55442814
117CDK30.53161479
118RAF10.52288915
119CSNK1G30.51617686
120MAPK110.51556483
121CAMKK20.50992172
122GRK70.50259661
123VRK20.50082159
124SYK0.49346402
125IGF1R0.49341406
126RIPK10.48622746
127PAK10.48448139
128PRKAA20.47166934
129CHUK0.46253532
130CSNK1G20.46187095
131EIF2AK20.45822236
132NEK10.45583205
133AURKA0.45230800
134PRKG20.45058373
135CDK20.44800446
136CDK90.43911617
137MAP2K10.43772459
138BTK0.43174344
139BCR0.42912703
140PHKG10.42829025
141PHKG20.42829025
142CAMK10.42433509
143NME10.42335857
144MAPKAPK50.41932915
145GRK50.40913377
146MAP3K140.39559765
147ICK0.39218729
148PKN20.38970974
149MAP3K80.37848586
150BMPR20.37528725
151GRK60.37446963
152PTK60.37300347
153NTRK20.36744916
154MATK0.36656139
155PDGFRB0.36045710
156PTK2B0.35113734
157PRKD20.33402215
158HCK0.33111893
159CCNB10.32842495
160ERBB40.32609353
161PKN10.32184146
162PTK20.31577177
163ABL10.31490984
164CDK60.31408841
165PIM10.31354566
166LYN0.30703932
167CAMK1D0.30031538
168ATM0.29242333
169JAK20.27678046
170ZAP700.25208656
171ATR0.25007405
172CDK10.24775736

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.81418471
2RNA polymerase_Homo sapiens_hsa030203.40177655
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32174607
4Caffeine metabolism_Homo sapiens_hsa002323.25341081
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.82366294
6Vitamin digestion and absorption_Homo sapiens_hsa049772.81317676
7Folate biosynthesis_Homo sapiens_hsa007902.79609635
8Phototransduction_Homo sapiens_hsa047442.64916271
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46483414
10Cell cycle_Homo sapiens_hsa041102.32594171
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28063665
12RNA transport_Homo sapiens_hsa030132.17519855
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11099267
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08185720
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01287028
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.00956854
17Ether lipid metabolism_Homo sapiens_hsa005651.93337688
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.92596412
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.91647200
20Asthma_Homo sapiens_hsa053101.77711660
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77441942
22Basal transcription factors_Homo sapiens_hsa030221.70260298
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.69795363
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66977687
25Arginine biosynthesis_Homo sapiens_hsa002201.66013576
26Olfactory transduction_Homo sapiens_hsa047401.65992249
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.65099243
28Arachidonic acid metabolism_Homo sapiens_hsa005901.65016024
29ABC transporters_Homo sapiens_hsa020101.62809571
30Nitrogen metabolism_Homo sapiens_hsa009101.52631392
31Pentose phosphate pathway_Homo sapiens_hsa000301.52430072
32Pyrimidine metabolism_Homo sapiens_hsa002401.51934091
33Sulfur relay system_Homo sapiens_hsa041221.49155938
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.46583444
35p53 signaling pathway_Homo sapiens_hsa041151.43701521
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42901195
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40078638
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39109838
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30778200
40Complement and coagulation cascades_Homo sapiens_hsa046101.30383856
41Biosynthesis of amino acids_Homo sapiens_hsa012301.30054608
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29326243
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.27730841
44Allograft rejection_Homo sapiens_hsa053301.27278767
45Autoimmune thyroid disease_Homo sapiens_hsa053201.24423049
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23792269
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23725853
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.20275782
49Type I diabetes mellitus_Homo sapiens_hsa049401.19974555
50Regulation of autophagy_Homo sapiens_hsa041401.19323779
51Small cell lung cancer_Homo sapiens_hsa052221.18759421
52Butanoate metabolism_Homo sapiens_hsa006501.18081441
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.17881981
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16136828
55Primary immunodeficiency_Homo sapiens_hsa053401.14257982
56Selenocompound metabolism_Homo sapiens_hsa004501.11919406
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11564218
58Oocyte meiosis_Homo sapiens_hsa041141.06940253
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05436814
60Graft-versus-host disease_Homo sapiens_hsa053321.04806767
61Protein export_Homo sapiens_hsa030601.04453834
62Purine metabolism_Homo sapiens_hsa002301.03678088
63Circadian rhythm_Homo sapiens_hsa047101.02149132
64Spliceosome_Homo sapiens_hsa030400.97518439
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.95492558
66mRNA surveillance pathway_Homo sapiens_hsa030150.94003084
67Rheumatoid arthritis_Homo sapiens_hsa053230.92072667
68Fatty acid degradation_Homo sapiens_hsa000710.91575738
69Fanconi anemia pathway_Homo sapiens_hsa034600.88469366
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86128056
71Dorso-ventral axis formation_Homo sapiens_hsa043200.84078722
72Bile secretion_Homo sapiens_hsa049760.82718836
73Taste transduction_Homo sapiens_hsa047420.82325097
74Morphine addiction_Homo sapiens_hsa050320.82209736
75Lysine degradation_Homo sapiens_hsa003100.81911007
76ECM-receptor interaction_Homo sapiens_hsa045120.81597504
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81496084
78Arginine and proline metabolism_Homo sapiens_hsa003300.81170460
79Oxidative phosphorylation_Homo sapiens_hsa001900.81077416
80Hematopoietic cell lineage_Homo sapiens_hsa046400.79047623
81DNA replication_Homo sapiens_hsa030300.78764155
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.78709446
83Nicotine addiction_Homo sapiens_hsa050330.78656243
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77785415
85Tryptophan metabolism_Homo sapiens_hsa003800.77393096
86Serotonergic synapse_Homo sapiens_hsa047260.77143367
87PPAR signaling pathway_Homo sapiens_hsa033200.76204529
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74450377
89Fatty acid metabolism_Homo sapiens_hsa012120.71336617
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70790275
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69448932
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67399160
93Retinol metabolism_Homo sapiens_hsa008300.67272257
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66034409
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65841736
96Glycerolipid metabolism_Homo sapiens_hsa005610.65374692
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64267296
98mTOR signaling pathway_Homo sapiens_hsa041500.63627159
99TGF-beta signaling pathway_Homo sapiens_hsa043500.62337387
100beta-Alanine metabolism_Homo sapiens_hsa004100.60179692
101Fatty acid elongation_Homo sapiens_hsa000620.59898141
102Protein digestion and absorption_Homo sapiens_hsa049740.59890149
103Metabolic pathways_Homo sapiens_hsa011000.58473362
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58460259
105Salivary secretion_Homo sapiens_hsa049700.57081991
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.56690596
107Peroxisome_Homo sapiens_hsa041460.56274524
108Homologous recombination_Homo sapiens_hsa034400.55961466
109MicroRNAs in cancer_Homo sapiens_hsa052060.55851982
110Sphingolipid metabolism_Homo sapiens_hsa006000.54564949
111RNA degradation_Homo sapiens_hsa030180.52413793
112Insulin resistance_Homo sapiens_hsa049310.51930336
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.51860469
114Herpes simplex infection_Homo sapiens_hsa051680.51743519
115Base excision repair_Homo sapiens_hsa034100.51684492
116Carbon metabolism_Homo sapiens_hsa012000.50875204
117Sulfur metabolism_Homo sapiens_hsa009200.49814072
118Collecting duct acid secretion_Homo sapiens_hsa049660.49506397
119One carbon pool by folate_Homo sapiens_hsa006700.49341862
120Parkinsons disease_Homo sapiens_hsa050120.48832408
121FoxO signaling pathway_Homo sapiens_hsa040680.48354733
122Calcium signaling pathway_Homo sapiens_hsa040200.47281105
123Glutathione metabolism_Homo sapiens_hsa004800.46333017
124Nucleotide excision repair_Homo sapiens_hsa034200.45865455
125Circadian entrainment_Homo sapiens_hsa047130.45254120
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44964193
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44268351
128Platelet activation_Homo sapiens_hsa046110.43686184
129Non-homologous end-joining_Homo sapiens_hsa034500.42857759
130Notch signaling pathway_Homo sapiens_hsa043300.42674629
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42615904
132Propanoate metabolism_Homo sapiens_hsa006400.42218062
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42066450
134Chemical carcinogenesis_Homo sapiens_hsa052040.41832542
135Epstein-Barr virus infection_Homo sapiens_hsa051690.41375298
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41020897
137Insulin secretion_Homo sapiens_hsa049110.39866909
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39652513
139Ovarian steroidogenesis_Homo sapiens_hsa049130.37130730
140Hippo signaling pathway_Homo sapiens_hsa043900.36533200
141Renin-angiotensin system_Homo sapiens_hsa046140.34192581
142Adherens junction_Homo sapiens_hsa045200.34006521
143African trypanosomiasis_Homo sapiens_hsa051430.33662510
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32904870
145Prostate cancer_Homo sapiens_hsa052150.32902478
146Renal cell carcinoma_Homo sapiens_hsa052110.32858134
147Focal adhesion_Homo sapiens_hsa045100.32647358
148AMPK signaling pathway_Homo sapiens_hsa041520.30502838
149Thyroid cancer_Homo sapiens_hsa052160.29878897
150Linoleic acid metabolism_Homo sapiens_hsa005910.29475879
151Amoebiasis_Homo sapiens_hsa051460.29271875
152VEGF signaling pathway_Homo sapiens_hsa043700.29237421
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.29133123
154Fat digestion and absorption_Homo sapiens_hsa049750.28804778
155Fatty acid biosynthesis_Homo sapiens_hsa000610.28339589
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27970597
157Mineral absorption_Homo sapiens_hsa049780.27533920

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