EXOC3L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.13862776
2regulation of fibrinolysis (GO:0051917)6.66295060
3drug catabolic process (GO:0042737)6.62997601
4complement activation, alternative pathway (GO:0006957)6.50919064
5regulation of protein activation cascade (GO:2000257)6.47693764
6negative regulation of fibrinolysis (GO:0051918)6.36297671
7peptidyl-glutamic acid carboxylation (GO:0017187)6.35161033
8protein carboxylation (GO:0018214)6.35161033
9exogenous drug catabolic process (GO:0042738)6.34624468
10regulation of complement activation (GO:0030449)6.23089295
11glyoxylate metabolic process (GO:0046487)6.05264614
12L-phenylalanine catabolic process (GO:0006559)5.99434319
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.99434319
14negative regulation of sterol transport (GO:0032372)5.80159715
15negative regulation of cholesterol transport (GO:0032375)5.80159715
16omega-hydroxylase P450 pathway (GO:0097267)5.73410024
17angiotensin maturation (GO:0002003)5.73382464
18intestinal cholesterol absorption (GO:0030299)5.59799820
19intestinal absorption (GO:0050892)5.47623237
20protein-lipid complex remodeling (GO:0034368)5.46497506
21macromolecular complex remodeling (GO:0034367)5.46497506
22plasma lipoprotein particle remodeling (GO:0034369)5.46497506
23L-phenylalanine metabolic process (GO:0006558)5.42186934
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.42186934
25high-density lipoprotein particle remodeling (GO:0034375)5.28768181
26drug metabolic process (GO:0017144)5.24751608
27blood coagulation, intrinsic pathway (GO:0007597)5.02801234
28very-low-density lipoprotein particle assembly (GO:0034379)4.87246244
29aromatic amino acid family catabolic process (GO:0009074)4.87025827
30ethanol oxidation (GO:0006069)4.84735410
31fibrinolysis (GO:0042730)4.79134952
32regulation of plasminogen activation (GO:0010755)4.77855348
33adhesion of symbiont to host cell (GO:0044650)4.71671096
34virion attachment to host cell (GO:0019062)4.71671096
35complement activation, classical pathway (GO:0006958)4.68279073
36urea metabolic process (GO:0019627)4.66453039
37protein activation cascade (GO:0072376)4.65539788
38serine family amino acid catabolic process (GO:0009071)4.56945588
39plasma lipoprotein particle organization (GO:0071827)4.51315104
40acylglycerol homeostasis (GO:0055090)4.42548098
41triglyceride homeostasis (GO:0070328)4.42548098
42arginine metabolic process (GO:0006525)4.42470152
43phenylpropanoid metabolic process (GO:0009698)4.42344848
44complement activation (GO:0006956)4.34986656
45oxidative demethylation (GO:0070989)4.33590917
46low-density lipoprotein particle remodeling (GO:0034374)4.33309357
47imidazole-containing compound metabolic process (GO:0052803)4.32708581
48regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.26443363
49cellular glucuronidation (GO:0052695)4.23905401
50urea cycle (GO:0000050)4.21992436
51vitamin A metabolic process (GO:0006776)4.13359118
52protein-lipid complex subunit organization (GO:0071825)4.13354914
53uronic acid metabolic process (GO:0006063)4.13240751
54glucuronate metabolic process (GO:0019585)4.13240751
55positive regulation of fatty acid biosynthetic process (GO:0045723)4.12493015
56adhesion of symbiont to host (GO:0044406)4.12404380
57nitrogen cycle metabolic process (GO:0071941)4.10318981
58negative regulation of hemostasis (GO:1900047)4.10142076
59negative regulation of blood coagulation (GO:0030195)4.10142076
60acute-phase response (GO:0006953)4.05845761
61negative regulation of lipase activity (GO:0060192)3.99836015
62bile acid metabolic process (GO:0008206)3.96084612
63alkaloid metabolic process (GO:0009820)3.95430728
64plasma lipoprotein particle clearance (GO:0034381)3.87316319
65tryptophan catabolic process (GO:0006569)3.87107168
66indole-containing compound catabolic process (GO:0042436)3.87107168
67indolalkylamine catabolic process (GO:0046218)3.87107168
68regulation of humoral immune response (GO:0002920)3.86425995
69ethanol metabolic process (GO:0006067)3.85776467
70bile acid biosynthetic process (GO:0006699)3.84791575
71negative regulation of protein activation cascade (GO:2000258)3.78432433
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75652459
73glutamate metabolic process (GO:0006536)3.74718474
74negative regulation of coagulation (GO:0050819)3.73863438
75arginine catabolic process (GO:0006527)3.73495387
76proline metabolic process (GO:0006560)3.72749791
77bile acid and bile salt transport (GO:0015721)3.68032839
78regulation of apoptotic cell clearance (GO:2000425)3.65040650
79response to peptidoglycan (GO:0032494)3.63555789
80negative regulation of wound healing (GO:0061045)3.63538285
81heme transport (GO:0015886)3.63318197
82neutrophil activation involved in immune response (GO:0002283)3.62349694
83Peyers patch development (GO:0048541)3.59584522
84mucosal-associated lymphoid tissue development (GO:0048537)3.59584522
85regulation of activation of Janus kinase activity (GO:0010533)3.56933086
86fat-soluble vitamin biosynthetic process (GO:0042362)3.49275207
87regulation of bile acid biosynthetic process (GO:0070857)3.48918137
88positive regulation of triglyceride metabolic process (GO:0090208)3.48738134
89alpha-amino acid catabolic process (GO:1901606)3.45431251
90positive regulation of interferon-alpha production (GO:0032727)3.44145061
91lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39993621
92positive regulation of type 2 immune response (GO:0002830)3.39520347
93antigen processing and presentation of endogenous antigen (GO:0019883)3.38965268
94peptidyl-glutamic acid modification (GO:0018200)3.38628668
95S-adenosylmethionine metabolic process (GO:0046500)3.38441574
96positive regulation of natural killer cell differentiation (GO:0032825)3.38184319
97regulation of RIG-I signaling pathway (GO:0039535)3.37442500
98regulation of T-helper 1 cell differentiation (GO:0045625)3.36897760
99drug transmembrane transport (GO:0006855)3.35645458
100tyrosine metabolic process (GO:0006570)3.35300042
101cholesterol homeostasis (GO:0042632)3.32641267
102T-helper 1 type immune response (GO:0042088)3.31853204
103acute inflammatory response (GO:0002526)3.31200329
104positive regulation of hemostasis (GO:1900048)3.31051474
105positive regulation of blood coagulation (GO:0030194)3.31051474
106myeloid dendritic cell differentiation (GO:0043011)3.29882795
107hydrogen peroxide biosynthetic process (GO:0050665)3.29258414
108glycine metabolic process (GO:0006544)3.27756309
109sterol homeostasis (GO:0055092)3.26722481
110phospholipid efflux (GO:0033700)3.26141480
111low-density lipoprotein particle clearance (GO:0034383)3.22669315
112regulation of cholesterol esterification (GO:0010872)3.22070067
113regulation of interferon-alpha production (GO:0032647)3.21851754
114response to muramyl dipeptide (GO:0032495)3.16822718
115response to type I interferon (GO:0034340)3.16585242
116cellular response to type I interferon (GO:0071357)3.13916367
117type I interferon signaling pathway (GO:0060337)3.13916367
118granulocyte activation (GO:0036230)3.13408362
119positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.12307943
120triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.11869682
121negative regulation of viral genome replication (GO:0045071)3.09123602
122positive regulation of triglyceride lipase activity (GO:0061365)3.07989127
123positive regulation of lipoprotein lipase activity (GO:0051006)3.07989127
124positive regulation of chemokine biosynthetic process (GO:0045080)3.06286258
125regulation of integrin activation (GO:0033623)3.05882196
126myeloid dendritic cell activation (GO:0001773)3.05721373
127mature B cell differentiation involved in immune response (GO:0002313)3.05463586
128bundle of His cell to Purkinje myocyte communication (GO:0086069)3.05150242
129neutrophil activation (GO:0042119)3.01440930
130regulation of cellular extravasation (GO:0002691)2.97184983
131NIK/NF-kappaB signaling (GO:0038061)2.95770614
132positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.92595701
133immunoglobulin mediated immune response (GO:0016064)2.91411629
134regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91323655
135striated muscle atrophy (GO:0014891)2.87046466
136positive regulation of monocyte chemotaxis (GO:0090026)2.86211858
137plasma lipoprotein particle assembly (GO:0034377)2.84933220
138protein-lipid complex assembly (GO:0065005)2.84094170
139reactive oxygen species biosynthetic process (GO:1903409)2.83273206
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83067355
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83067355
142positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.81031642
143modulation by symbiont of host immune response (GO:0052553)2.78494458
144positive regulation by symbiont of host defense response (GO:0052509)2.78494458
145modulation by symbiont of host defense response (GO:0052031)2.78494458
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.78494458
147modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.78494458
148positive regulation by organism of defense response of other organism involved in symbiotic interact2.78494458
149cholesterol efflux (GO:0033344)2.78250456
150eosinophil chemotaxis (GO:0048245)2.77890663
151response to interferon-alpha (GO:0035455)2.75570682
152lipoprotein metabolic process (GO:0042157)2.75447438
153monocyte chemotaxis (GO:0002548)2.74740387
154regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.73542334
155positive regulation of interleukin-12 production (GO:0032735)2.72040366
156regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.70620983
157positive regulation of antigen processing and presentation (GO:0002579)2.70410799
158thrombin receptor signaling pathway (GO:0070493)2.69916425
159positive regulation of T-helper cell differentiation (GO:0045624)2.69427569
160peptide catabolic process (GO:0043171)2.68400856
161lipoprotein transport (GO:0042953)2.67865480
162regulation of heterotypic cell-cell adhesion (GO:0034114)2.65823663
163regulation of chemokine biosynthetic process (GO:0045073)2.65690538
164dendritic cell differentiation (GO:0097028)2.65631492
165regulation of vitamin metabolic process (GO:0030656)2.64499923
166hepatocyte apoptotic process (GO:0097284)2.64212417
167positive regulation of heat generation (GO:0031652)2.63956510
168interferon-gamma-mediated signaling pathway (GO:0060333)2.63191352
169reverse cholesterol transport (GO:0043691)2.58242853
170mature B cell differentiation (GO:0002335)2.57945238
171regulation of triglyceride catabolic process (GO:0010896)2.57881758
172natural killer cell differentiation (GO:0001779)2.57179639
173natural killer cell mediated immunity (GO:0002228)2.56043481
174natural killer cell mediated cytotoxicity (GO:0042267)2.56043481
175regulation of fever generation (GO:0031620)2.54976843
176flavonoid metabolic process (GO:0009812)2.54687871
177positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54644024
178response to interferon-beta (GO:0035456)2.53831970
179positive regulation of gamma-delta T cell activation (GO:0046645)2.53424414
180positive regulation of interleukin-2 production (GO:0032743)2.52500786
181positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52479333
182regulation of vitamin D biosynthetic process (GO:0060556)2.52391082
183regulation of cholesterol storage (GO:0010885)2.52376870
184macrophage activation involved in immune response (GO:0002281)2.52144634
185regulation of podosome assembly (GO:0071801)2.50442319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.07948372
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.62891122
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.93073827
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.17733293
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.13504051
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.73146998
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.61371188
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.07343637
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.03524983
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.02474800
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89701013
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.64796394
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.61219355
14CDX2_20551321_ChIP-Seq_CACO-2_Human2.59615718
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55942567
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.43010158
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39476231
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28592506
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28579773
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21872498
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.19239552
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.09004686
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08062632
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02030630
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.00847055
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.96255004
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95738473
28HNF4A_19822575_ChIP-Seq_HepG2_Human1.94948849
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89770914
30SOX2_20726797_ChIP-Seq_SW620_Human1.84899534
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84720633
32VDR_22108803_ChIP-Seq_LS180_Human1.84293790
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84069059
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83455746
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80647019
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80422989
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74440869
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72008443
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68628771
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67433627
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66987443
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66944054
43GATA4_25053715_ChIP-Seq_YYC3_Human1.65898332
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62479934
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61625063
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.59749827
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59264726
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54430902
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.54216494
50DROSHA_22980978_ChIP-Seq_HELA_Human1.50195311
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.45703918
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44946121
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43963765
54VDR_24787735_ChIP-Seq_THP-1_Human1.42331051
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41079320
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.40838103
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40630483
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39600061
59HTT_18923047_ChIP-ChIP_STHdh_Human1.38740658
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38029343
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35775980
62GATA6_25053715_ChIP-Seq_YYC3_Human1.34823498
63TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32976706
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30566181
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29264547
66BCAT_22108803_ChIP-Seq_LS180_Human1.28062315
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27488363
68ZNF274_21170338_ChIP-Seq_K562_Hela1.26511691
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24422953
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23218830
71IGF1R_20145208_ChIP-Seq_DFB_Human1.23036178
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.22882705
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21986766
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20611116
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18835098
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17425273
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16791281
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.16736435
79MYC_19829295_ChIP-Seq_ESCs_Human1.16602631
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15908842
81CLOCK_20551151_ChIP-Seq_293T_Human1.15450060
82VDR_24763502_ChIP-Seq_THP-1_Human1.13806034
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13563109
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13256533
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13256533
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12781546
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11959422
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11834741
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10942375
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10627070
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.08070134
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06108615
93RACK7_27058665_Chip-Seq_MCF-7_Human1.05195561
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05076712
95EGR1_19032775_ChIP-ChIP_M12_Human1.04141716
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03862506
97GATA2_19941826_ChIP-Seq_K562_Human1.03383681
98P53_21459846_ChIP-Seq_SAOS-2_Human1.03153994
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.02611132
100AR_20517297_ChIP-Seq_VCAP_Human1.02396830
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01950226
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01776353
103SPI1_23127762_ChIP-Seq_K562_Human1.01541735
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01370075
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01110688
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01016834
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99746298
108RAC3_21632823_ChIP-Seq_H3396_Human0.99740776
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.99679618
110PU_27001747_Chip-Seq_BMDM_Mouse0.99059249
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98699350
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98342349
113SPI1_23547873_ChIP-Seq_NB4_Human0.98121859
114CJUN_26792858_Chip-Seq_BT549_Human0.97837935
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96980490
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96374024
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96374024
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96325782
119NANOG_20526341_ChIP-Seq_ESCs_Human0.95737667
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94593089
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.94410752
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94215558
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.92688069
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92228694
125GATA1_22025678_ChIP-Seq_K562_Human0.92161971
126ERA_21632823_ChIP-Seq_H3396_Human0.92115471
127MAF_26560356_Chip-Seq_TH1_Human0.92005457
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91989930
129EZH2_22144423_ChIP-Seq_EOC_Human0.91871779
130GATA1_19941826_ChIP-Seq_K562_Human0.91083009
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90333386
132FOXH1_21741376_ChIP-Seq_ESCs_Human0.89968644
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89845855
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89736195
135OCT4_20526341_ChIP-Seq_ESCs_Human0.89252193
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88486049
137NCOR_22424771_ChIP-Seq_293T_Human0.88321293
138CTCF_27219007_Chip-Seq_Bcells_Human0.88031153
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87633837
140CEBPB_22108803_ChIP-Seq_LS180_Human0.87537704
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87519558
142E2F1_20622854_ChIP-Seq_HELA_Human0.86285991
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.85591484
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84955154
145SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84924104
146SOX2_21211035_ChIP-Seq_LN229_Human0.84393721
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84333150
148REST_21632747_ChIP-Seq_MESCs_Mouse0.84072768
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83735506
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83246709
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82874130
152RUNX1_22412390_ChIP-Seq_EML_Mouse0.82840942
153TAF2_19829295_ChIP-Seq_ESCs_Human0.82193736
154TCF4_22108803_ChIP-Seq_LS180_Human0.81925708
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81012772
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80333931
157CDX2_22108803_ChIP-Seq_LS180_Human0.80284767
158AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80134015
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79645340
160CTCF_20526341_ChIP-Seq_ESCs_Human0.79600474
161GATA3_21878914_ChIP-Seq_MCF-7_Human0.79010480
162BCL6_27268052_Chip-Seq_Bcells_Human0.78997472
163SCL_19346495_ChIP-Seq_HPC-7_Human0.78535368
164SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.78244096
165SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78102913
166FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77746066
167FOXA1_25329375_ChIP-Seq_VCAP_Human0.75911986
168FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75911986
169FOXH1_21741376_ChIP-Seq_EPCs_Human0.75561955
170NANOG_19829295_ChIP-Seq_ESCs_Human0.75405134
171SOX2_19829295_ChIP-Seq_ESCs_Human0.75405134
172CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75184810
173SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73872482
174SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.72562328
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71072061
176SA1_27219007_Chip-Seq_Bcells_Human0.70701694
177REST_18959480_ChIP-ChIP_MESCs_Mouse0.70536284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.83843388
2MP0005365_abnormal_bile_salt5.32605413
3MP0005360_urolithiasis4.67284928
4MP0002254_reproductive_system_inflammat3.95597792
5MP0001835_abnormal_antigen_presentation3.41108766
6MP0000685_abnormal_immune_system3.10186951
7MP0009785_altered_susceptibility_to3.07258348
8MP0002148_abnormal_hypersensitivity_rea3.02517515
9MP0003436_decreased_susceptibility_to2.90788928
10MP0001666_abnormal_nutrient_absorption2.89756313
11MP0004264_abnormal_extraembryonic_tissu2.89021070
12MP0009840_abnormal_foam_cell2.87192922
13MP0006082_CNS_inflammation2.62323298
14MP0003183_abnormal_peptide_metabolism2.59985004
15MP0005671_abnormal_response_to2.46654792
16MP0005332_abnormal_amino_acid2.45097004
17MP0003724_increased_susceptibility_to2.43689942
18MP0001790_abnormal_immune_system2.20495608
19MP0005387_immune_system_phenotype2.20495608
20MP0005000_abnormal_immune_tolerance2.16206707
21MP0005025_abnormal_response_to2.14936718
22MP0002419_abnormal_innate_immunity2.09849117
23MP0004510_myositis2.08573015
24MP0010155_abnormal_intestine_physiology1.98464015
25MP0004947_skin_inflammation1.95574372
26MP0009764_decreased_sensitivity_to1.82613340
27MP0003868_abnormal_feces_composition1.82083245
28MP0000566_synostosis1.76703370
29MP0001764_abnormal_homeostasis1.73103161
30MP0002452_abnormal_antigen_presenting1.72184006
31MP0001533_abnormal_skeleton_physiology1.71131613
32MP0003303_peritoneal_inflammation1.70716181
33MP0005464_abnormal_platelet_physiology1.69104015
34MP0003705_abnormal_hypodermis_morpholog1.66663506
35MP0005167_abnormal_blood-brain_barrier1.65484552
36MP0002118_abnormal_lipid_homeostasis1.64747398
37MP0002723_abnormal_immune_serum1.58508222
38MP0001346_abnormal_lacrimal_gland1.55680722
39MP0001845_abnormal_inflammatory_respons1.54557960
40MP0002006_tumorigenesis1.52250826
41MP0003879_abnormal_hair_cell1.51503514
42MP0001800_abnormal_humoral_immune1.48307213
43MP0010352_gastrointestinal_tract_polyps1.48283567
44MP0009333_abnormal_splenocyte_physiolog1.47467655
45MP0003866_abnormal_defecation1.44816683
46MP0010329_abnormal_lipoprotein_level1.44756407
47MP0001819_abnormal_immune_cell1.43197373
48MP0005076_abnormal_cell_differentiation1.37468744
49MP0002420_abnormal_adaptive_immunity1.36586373
50MP0001853_heart_inflammation1.36262755
51MP0003448_altered_tumor_morphology1.36232089
52MP0005310_abnormal_salivary_gland1.36164795
53MP0008469_abnormal_protein_level1.35513765
54MP0006292_abnormal_olfactory_placode1.34182548
55MP0003122_maternal_imprinting1.32086150
56MP0002876_abnormal_thyroid_physiology1.30981320
57MP0003252_abnormal_bile_duct1.29849659
58MP0003806_abnormal_nucleotide_metabolis1.29514639
59MP0002405_respiratory_system_inflammati1.28841805
60MP0003191_abnormal_cellular_cholesterol1.28735004
61MP0010234_abnormal_vibrissa_follicle1.28552043
62MP0003566_abnormal_cell_adhesion1.28111712
63MP0001873_stomach_inflammation1.25230244
64MP0008872_abnormal_physiological_respon1.20629973
65MP0004019_abnormal_vitamin_homeostasis1.19495325
66MP0003453_abnormal_keratinocyte_physiol1.19477865
67MP0001348_abnormal_lacrimal_gland1.19011808
68MP0003075_altered_response_to1.18567992
69MP0006054_spinal_hemorrhage1.18201205
70MP0002139_abnormal_hepatobiliary_system1.16441283
71MP0009697_abnormal_copulation1.14719107
72MP0002998_abnormal_bone_remodeling1.14370080
73MP0000343_altered_response_to1.12308292
74MP0005636_abnormal_mineral_homeostasis1.12267105
75MP0009278_abnormal_bone_marrow1.11653711
76MP0002877_abnormal_melanocyte_morpholog1.09283066
77MP0010368_abnormal_lymphatic_system1.08754241
78MP0001881_abnormal_mammary_gland1.08352479
79MP0002166_altered_tumor_susceptibility1.07850884
80MP0001663_abnormal_digestive_system1.07412348
81MP0005551_abnormal_eye_electrophysiolog1.07270188
82MP0005166_decreased_susceptibility_to1.07011475
83MP0005023_abnormal_wound_healing1.05034308
84MP0003091_abnormal_cell_migration1.04033651
85MP0005084_abnormal_gallbladder_morpholo0.99539572
86MP0005670_abnormal_white_adipose0.99290570
87MP0000858_altered_metastatic_potential0.97689245
88MP0000716_abnormal_immune_system0.96037300
89MP0004272_abnormal_basement_membrane0.94761539
90MP0000249_abnormal_blood_vessel0.94580611
91MP0004043_abnormal_pH_regulation0.93561139
92MP0000604_amyloidosis0.93356610
93MP0003300_gastrointestinal_ulcer0.92309110
94MP0005646_abnormal_pituitary_gland0.90395460
95MP0009643_abnormal_urine_homeostasis0.89375709
96MP0005085_abnormal_gallbladder_physiolo0.88343340
97MP0009642_abnormal_blood_homeostasis0.88122272
98MP0005164_abnormal_response_to0.88098422
99MP0009780_abnormal_chondrocyte_physiolo0.87903845
100MP0002136_abnormal_kidney_physiology0.86202465
101MP0005083_abnormal_biliary_tract0.85377593
102MP0002796_impaired_skin_barrier0.81602285
103MP0003186_abnormal_redox_activity0.81539809
104MP0002138_abnormal_hepatobiliary_system0.81489823
105MP0005448_abnormal_energy_balance0.81080673
106MP0003718_maternal_effect0.79446240
107MP0000598_abnormal_liver_morphology0.79016545
108MP0005319_abnormal_enzyme/_coenzyme0.78815148
109MP0002429_abnormal_blood_cell0.78668747
110MP0002398_abnormal_bone_marrow0.78652249
111MP0003011_delayed_dark_adaptation0.78350073
112MP0005408_hypopigmentation0.77905394
113MP0001879_abnormal_lymphatic_vessel0.77629449
114MP0008875_abnormal_xenobiotic_pharmacok0.77292677
115MP0005381_digestive/alimentary_phenotyp0.77052750
116MP0000609_abnormal_liver_physiology0.76275957
117MP0003828_pulmonary_edema0.75421524
118MP0004147_increased_porphyrin_level0.75053048
119MP0002653_abnormal_ependyma_morphology0.74954801
120MP0002971_abnormal_brown_adipose0.73811860
121MP0005395_other_phenotype0.73044788
122MP0005058_abnormal_lysosome_morphology0.72789632
123MP0005390_skeleton_phenotype0.72757119
124MP0005584_abnormal_enzyme/coenzyme_acti0.71052643
125MP0000627_abnormal_mammary_gland0.70717182
126MP0005397_hematopoietic_system_phenotyp0.70479392
127MP0001545_abnormal_hematopoietic_system0.70479392
128MP0000490_abnormal_crypts_of0.70033460
129MP0002132_abnormal_respiratory_system0.69925098
130MP0008004_abnormal_stomach_pH0.69894671
131MP0004782_abnormal_surfactant_physiolog0.69824424
132MP0009763_increased_sensitivity_to0.69411081
133MP0005451_abnormal_body_composition0.67985171
134MP0002277_abnormal_respiratory_mucosa0.67775272
135MP0001485_abnormal_pinna_reflex0.66182796
136MP0005379_endocrine/exocrine_gland_phen0.66167558
137MP0002909_abnormal_adrenal_gland0.66066882
138MP0003123_paternal_imprinting0.64494066
139MP0000639_abnormal_adrenal_gland0.63696430
140MP0002249_abnormal_larynx_morphology0.61831109
141MP0003953_abnormal_hormone_level0.61269226
142MP0002078_abnormal_glucose_homeostasis0.61010576
143MP0002282_abnormal_trachea_morphology0.59557190
144MP0001986_abnormal_taste_sensitivity0.59063638
145MP0002089_abnormal_postnatal_growth/wei0.58292916
146MP0001756_abnormal_urination0.57790508
147MP0005645_abnormal_hypothalamus_physiol0.56709073
148MP0003172_abnormal_lysosome_physiology0.56393207
149MP0001501_abnormal_sleep_pattern0.56253901
150MP0000678_abnormal_parathyroid_gland0.54071128
151MP0005535_abnormal_body_temperature0.53902237
152MP0003638_abnormal_response/metabolism_0.53716174
153MP0002168_other_aberrant_phenotype0.52627350
154MP0003329_amyloid_beta_deposits0.50218212
155MP0001661_extended_life_span0.49529424
156MP0003567_abnormal_fetal_cardiomyocyte0.46097221
157MP0005195_abnormal_posterior_eye0.44408598
158MP0005334_abnormal_fat_pad0.41003585
159MP0001324_abnormal_eye_pigmentation0.40738438
160MP0000026_abnormal_inner_ear0.40554861
161MP0005376_homeostasis/metabolism_phenot0.40530086
162MP0000538_abnormal_urinary_bladder0.39082239
163MP0002135_abnormal_kidney_morphology0.37928565
164MP0008775_abnormal_heart_ventricle0.37924870
165MP0010386_abnormal_urinary_bladder0.37464420
166MP0009115_abnormal_fat_cell0.37088993
167MP0004270_analgesia0.37004933
168MP0002234_abnormal_pharynx_morphology0.36412781
169MP0001765_abnormal_ion_homeostasis0.35564472
170MP0005377_hearing/vestibular/ear_phenot0.34831520
171MP0003878_abnormal_ear_physiology0.34831520

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.66803917
2Complement deficiency (HP:0004431)7.80221615
3Prolonged partial thromboplastin time (HP:0003645)7.78720410
4Autoimmune thrombocytopenia (HP:0001973)7.21322141
5Abnormality of monocarboxylic acid metabolism (HP:0010996)7.19332495
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.72442406
7Joint hemorrhage (HP:0005261)6.30085553
8Abnormality of complement system (HP:0005339)6.08728386
9Eczematoid dermatitis (HP:0000976)5.15093460
10Glomerulonephritis (HP:0000099)5.05600658
11Hyperlipoproteinemia (HP:0010980)4.75066349
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.72178172
13Abnormality of proline metabolism (HP:0010907)4.60661148
14Hydroxyprolinuria (HP:0003080)4.60661148
15Recurrent bacterial skin infections (HP:0005406)4.10991995
16Recurrent abscess formation (HP:0002722)4.05990883
17Autoimmune hemolytic anemia (HP:0001890)3.97886514
18Hemorrhage of the eye (HP:0011885)3.95615032
19Intrahepatic cholestasis (HP:0001406)3.84201790
20Right ventricular cardiomyopathy (HP:0011663)3.74020637
21Abnormality of pyrimidine metabolism (HP:0004353)3.66758817
22Abnormality of macrophages (HP:0004311)3.58176827
23Abnormality of serine family amino acid metabolism (HP:0010894)3.52398829
24Abnormality of glycine metabolism (HP:0010895)3.52398829
25Spontaneous abortion (HP:0005268)3.50983076
26Orchitis (HP:0100796)3.49966571
27Increased IgM level (HP:0003496)3.49520625
28Hyperglycinuria (HP:0003108)3.47509543
29Recurrent fungal infections (HP:0002841)3.43444931
30Elevated erythrocyte sedimentation rate (HP:0003565)3.42948279
31Recurrent gram-negative bacterial infections (HP:0005420)3.41500417
32Increased IgE level (HP:0003212)3.36969465
33Ileus (HP:0002595)3.34082596
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.24577459
35Myositis (HP:0100614)3.17638240
36Hypobetalipoproteinemia (HP:0003563)3.16545142
37Gingivitis (HP:0000230)3.15304001
38Hyperglycinemia (HP:0002154)3.13235875
39Pustule (HP:0200039)3.11849988
40Acanthocytosis (HP:0001927)3.11124687
41Epidermoid cyst (HP:0200040)3.10456684
42Abnormality of the common coagulation pathway (HP:0010990)3.09805996
43Optic neuritis (HP:0100653)3.08443724
44Retrobulbar optic neuritis (HP:0100654)3.08443724
45Interstitial pulmonary disease (HP:0006530)3.06408860
46Mediastinal lymphadenopathy (HP:0100721)3.05998569
47Tetraparesis (HP:0002273)3.00520950
48Petechiae (HP:0000967)2.98462638
49Delayed CNS myelination (HP:0002188)2.96659512
50Hypoalphalipoproteinemia (HP:0003233)2.95804251
51Thick nail (HP:0001805)2.90284554
52Pigmentary retinal degeneration (HP:0001146)2.90258799
53Esophageal varix (HP:0002040)2.88945661
54Vasculitis (HP:0002633)2.88324404
55Premature loss of primary teeth (HP:0006323)2.85170260
56Recurrent skin infections (HP:0001581)2.82693211
57Enlarged kidneys (HP:0000105)2.81321895
58Basal ganglia calcification (HP:0002135)2.80744279
59Hypergammaglobulinemia (HP:0010702)2.77996326
60Alopecia of scalp (HP:0002293)2.75301692
61Keratoconjunctivitis (HP:0001096)2.74581515
62Abnormality of the intrinsic pathway (HP:0010989)2.73865530
63Hypophosphatemic rickets (HP:0004912)2.71635741
64Facial shape deformation (HP:0011334)2.69160683
65Potter facies (HP:0002009)2.69160683
66Cupped ribs (HP:0000887)2.67411203
67Polycythemia (HP:0001901)2.65787933
68Hyperammonemia (HP:0001987)2.65395979
69Vascular calcification (HP:0004934)2.64131809
70Recurrent viral infections (HP:0004429)2.63772373
71Menorrhagia (HP:0000132)2.61419031
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60115886
73Eosinophilia (HP:0001880)2.60084929
74Mesangial abnormality (HP:0001966)2.57452522
75Abnormality of urine glucose concentration (HP:0011016)2.53382295
76Glycosuria (HP:0003076)2.53382295
77Leukocytosis (HP:0001974)2.53079195
78Chronic mucocutaneous candidiasis (HP:0002728)2.51225384
79Recurrent cutaneous fungal infections (HP:0011370)2.51225384
80Systemic lupus erythematosus (HP:0002725)2.48929505
81Abnormality of nucleobase metabolism (HP:0010932)2.40030236
82Abnormality of eosinophils (HP:0001879)2.34892584
83Urticaria (HP:0001025)2.34171722
84Mitral stenosis (HP:0001718)2.32578349
85Reticulocytosis (HP:0001923)2.32356546
86Axonal loss (HP:0003447)2.32035051
87Micronodular cirrhosis (HP:0001413)2.31563838
88Rickets (HP:0002748)2.30183532
89Malnutrition (HP:0004395)2.29953767
90Abnormality of sulfur amino acid metabolism (HP:0004339)2.28374951
91Granulocytopenia (HP:0001913)2.27323574
92Decreased central vision (HP:0007663)2.24590191
93Thrombophlebitis (HP:0004418)2.21862130
94Purpura (HP:0000979)2.21716034
95Abnormality of serum amino acid levels (HP:0003112)2.21667249
96Generalized aminoaciduria (HP:0002909)2.21039130
97Arterial thrombosis (HP:0004420)2.18873142
98Alkalosis (HP:0001948)2.18659151
99Pili torti (HP:0003777)2.18181743
100Increased mean platelet volume (HP:0011877)2.17154376
101Cardiovascular calcification (HP:0011915)2.16543625
102Metabolic acidosis (HP:0001942)2.16128837
103Combined immunodeficiency (HP:0005387)2.16019650
104Severe combined immunodeficiency (HP:0004430)2.15379583
105Periodontitis (HP:0000704)2.14963031
106Abnormality of the gastric mucosa (HP:0004295)2.14835445
107Widely patent fontanelles and sutures (HP:0004492)2.13970887
108Peritonitis (HP:0002586)2.13829704
109Nausea (HP:0002018)2.13722034
110Gastrointestinal infarctions (HP:0005244)2.13531747
111Pulmonary embolism (HP:0002204)2.12933937
112Chronic diarrhea (HP:0002028)2.12190909
113Abnormality of methionine metabolism (HP:0010901)2.11897899
114Late onset (HP:0003584)2.08806505
115Hypolipoproteinemia (HP:0010981)2.08797512
116Gout (HP:0001997)2.08667420
117Pulmonary infiltrates (HP:0002113)2.07785233
118Ketosis (HP:0001946)2.07738952
119Keratoconjunctivitis sicca (HP:0001097)2.07609662
120Abnormal platelet volume (HP:0011876)2.07471282
121Retinal atrophy (HP:0001105)2.06268343
122Cerebral palsy (HP:0100021)2.05223777
123Abnormality of vitamin metabolism (HP:0100508)2.05137384
124Vacuolated lymphocytes (HP:0001922)2.03119205
125Poikilocytosis (HP:0004447)2.02236492
126Osteomyelitis (HP:0002754)2.01857621
127Amyloidosis (HP:0011034)2.01496722
128Xanthomatosis (HP:0000991)2.01327652
129Bone pain (HP:0002653)2.00505926
130Osteomalacia (HP:0002749)1.98564097
131Cellulitis (HP:0100658)1.96012353
132Hepatocellular carcinoma (HP:0001402)1.95096559
133Steatorrhea (HP:0002570)1.94722589
134Increased connective tissue (HP:0009025)1.94066589
135Thyroiditis (HP:0100646)1.93131733
136Plantar hyperkeratosis (HP:0007556)1.91444147
137Hyperphosphaturia (HP:0003109)1.91281110
138Vertebral compression fractures (HP:0002953)1.91049111
139Hypercholesterolemia (HP:0003124)1.90902259
140Gingival bleeding (HP:0000225)1.89668013
141Abdominal distention (HP:0003270)1.87269176
142Chronic otitis media (HP:0000389)1.87245003
143Poor head control (HP:0002421)1.87170551
144Myocardial infarction (HP:0001658)1.87049863
145Osteolytic defects of the hand bones (HP:0009699)1.86432327
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.86432327
147Porencephaly (HP:0002132)1.86068698
148Fair hair (HP:0002286)1.85196755
149Hematochezia (HP:0002573)1.83189907
150Nephritis (HP:0000123)1.82086560
151Palmoplantar hyperkeratosis (HP:0000972)1.82011265
152Abnormality of purine metabolism (HP:0004352)1.81946303
153Colitis (HP:0002583)1.81554260
154Arthropathy (HP:0003040)1.80373006
155Conjugated hyperbilirubinemia (HP:0002908)1.79941385
156Nephrolithiasis (HP:0000787)1.79660572
157Abnormality of the pericardium (HP:0001697)1.79019202
158Abnormal platelet function (HP:0011869)1.78925842
159Impaired platelet aggregation (HP:0003540)1.78925842
160Prolonged neonatal jaundice (HP:0006579)1.77706496
161Fat malabsorption (HP:0002630)1.76930060
162Lethargy (HP:0001254)1.75583618
163Hepatoblastoma (HP:0002884)1.73917880
164Abnormal urine phosphate concentration (HP:0012599)1.71117766
165Hypophosphatemia (HP:0002148)1.70257703
166Hyperbilirubinemia (HP:0002904)1.69526079
167Pancreatitis (HP:0001733)1.67353013
168Joint swelling (HP:0001386)1.63259246
169Irritability (HP:0000737)1.62260283
170Gangrene (HP:0100758)1.59723682
171Bifid scrotum (HP:0000048)1.59675962
172Opisthotonus (HP:0002179)1.59096295
173Abnormality of transition element cation homeostasis (HP:0011030)1.58418765
174Confusion (HP:0001289)1.56175893
175Proximal tubulopathy (HP:0000114)1.56166991
176Abnormal biliary tract physiology (HP:0012439)1.55309582
177Bile duct proliferation (HP:0001408)1.55309582
178Skin nodule (HP:0200036)1.54231195
179Abnormality of the vitreous humor (HP:0004327)1.53100162
180Abnormal urine output (HP:0012590)1.51373271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.64035134
2MAP3K144.03855114
3TBK13.50293321
4TNIK3.45527028
5RIPK42.94896045
6PBK2.74456943
7STK162.60158562
8ERN12.56476141
9EPHB12.54362003
10WNK42.41227955
11FRK2.40021463
12WNK32.39377470
13MST1R2.36234616
14JAK32.30642266
15IRAK32.24826424
16DYRK1B2.22125727
17TYK22.19334931
18IKBKB2.10574067
19BMX2.03283211
20PTK61.97046169
21IKBKE1.92790935
22NTRK31.91728152
23STK101.91223901
24MAP4K21.89440145
25ACVR1B1.88434136
26PRKG21.82532912
27CASK1.81523702
28EPHA41.79216852
29ICK1.73663216
30MATK1.66805956
31PIM21.65983091
32IRAK41.60702057
33TESK11.60658107
34PIK3CA1.60594097
35MARK11.57518100
36ADRBK21.56798632
37BLK1.56329192
38SCYL21.54924356
39BCKDK1.48136607
40RIPK11.47857067
41MAP2K31.44026705
42TAOK31.39720442
43MAP3K41.38909249
44PINK11.38562322
45CHUK1.38023041
46MAPK131.32849662
47ZAK1.31914112
48EPHA21.29511964
49GRK11.29453698
50BMPR21.28008749
51PLK41.26725028
52INSRR1.19362041
53PDK21.18803643
54EPHA31.18159280
55JAK11.16356003
56PRKAA21.14533171
57LRRK21.12026791
58STK391.11770497
59KIT1.10820281
60NME11.10164777
61MAP3K101.09583488
62CSK1.09212138
63CSNK1A1L1.08933768
64ERBB21.08133045
65MARK31.07562088
66FGFR21.04474478
67MAP2K21.02519691
68PRKACG1.02486516
69NUAK11.00665934
70MAP3K130.98472809
71TYRO30.96155236
72MAP3K110.93800018
73GRK60.91249982
74KDR0.90937243
75MAP3K10.89425646
76DYRK20.88768768
77MAP2K40.88423852
78LMTK20.87777471
79PRKCG0.87644109
80BTK0.87494406
81MAP4K10.87467969
82TRIB30.87438163
83DAPK20.87256371
84MAP2K70.87036762
85FGFR40.86940430
86TNK20.86914573
87EPHB20.86813043
88JAK20.86631843
89PIM10.84296055
90TGFBR20.83660588
91BMPR1B0.82768408
92ABL20.82318405
93STK30.82224263
94ZAP700.81650083
95PTK20.80234203
96PRKCZ0.79609055
97DDR20.79226654
98NME20.76924497
99CSNK1G30.76059989
100PRKAA10.75657471
101PKN20.75619433
102MET0.74809816
103MAP2K60.74291000
104MAPK110.73989365
105TLK10.73516265
106ARAF0.71945546
107MAP3K20.71029240
108CDC42BPA0.70453370
109PRKACA0.70430210
110TXK0.69760302
111STK40.69681889
112MAP3K30.68433341
113SIK10.66859876
114MAPKAPK30.66601114
115IGF1R0.66043698
116OXSR10.64595953
117CSNK1G20.63816952
118SYK0.63014861
119FER0.63014705
120PAK40.62627810
121TIE10.62449799
122CSNK1G10.62152587
123MAP3K60.61354182
124MAPKAPK20.60341903
125PRKCD0.59152177
126PRKCA0.57172738
127CSF1R0.56705095
128PHKG20.55513502
129PHKG10.55513502
130KSR20.54561946
131LCK0.53942401
132MAP3K50.53774601
133AKT30.53663310
134FGFR30.53127766
135PRKCE0.51528910
136RET0.51436658
137MAP2K10.50670151
138LATS10.50104057
139TGFBR10.49728073
140FGR0.48588586
141CSNK1A10.48348354
142NLK0.48129796
143MAP3K80.47720365
144LIMK10.47542307
145PDK10.47013410
146PRKG10.46847304
147PDPK10.46137966
148HIPK20.45602917
149ABL10.45518199
150MUSK0.45316942
151HCK0.44932402
152EIF2AK20.44508880
153FGFR10.44225998
154NEK90.44015088
155PTK2B0.43505265
156DMPK0.42330735
157LYN0.41471021
158EGFR0.41174410
159MAP3K70.40899489
160RPS6KA40.40747481
161GRK70.40570861
162SRC0.39118025
163CSNK1D0.38878255
164SIK20.38220930
165BCR0.38152734
166ERBB30.37831935
167RAF10.37600467
168PAK30.35838634
169CSNK2A10.34526156

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.26247955
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.07985351
3Retinol metabolism_Homo sapiens_hsa008302.92909864
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.92573403
5Vitamin digestion and absorption_Homo sapiens_hsa049772.78546729
6Graft-versus-host disease_Homo sapiens_hsa053322.77494887
7Renin-angiotensin system_Homo sapiens_hsa046142.68587342
8Mineral absorption_Homo sapiens_hsa049782.68095642
9Chemical carcinogenesis_Homo sapiens_hsa052042.58110011
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52420028
11Leishmaniasis_Homo sapiens_hsa051402.47080926
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.42895172
13Fatty acid degradation_Homo sapiens_hsa000712.41371443
14Allograft rejection_Homo sapiens_hsa053302.38620341
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.33133692
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31921327
17Legionellosis_Homo sapiens_hsa051342.14092011
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10020715
19Phenylalanine metabolism_Homo sapiens_hsa003602.04264383
20Linoleic acid metabolism_Homo sapiens_hsa005912.00745310
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.98576535
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.95931187
23Butanoate metabolism_Homo sapiens_hsa006501.94927312
24TNF signaling pathway_Homo sapiens_hsa046681.94327170
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.90735598
26Caffeine metabolism_Homo sapiens_hsa002321.89814455
27African trypanosomiasis_Homo sapiens_hsa051431.87586253
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83811056
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83444573
30Tyrosine metabolism_Homo sapiens_hsa003501.77913547
31Galactose metabolism_Homo sapiens_hsa000521.77460124
32Pertussis_Homo sapiens_hsa051331.75716206
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73978369
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.72278766
35Malaria_Homo sapiens_hsa051441.64295326
36Salmonella infection_Homo sapiens_hsa051321.55622655
37Osteoclast differentiation_Homo sapiens_hsa043801.52970356
38Influenza A_Homo sapiens_hsa051641.52481157
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52260501
40Starch and sucrose metabolism_Homo sapiens_hsa005001.51949833
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49461436
42Rheumatoid arthritis_Homo sapiens_hsa053231.44908327
43Type I diabetes mellitus_Homo sapiens_hsa049401.43730052
44Peroxisome_Homo sapiens_hsa041461.42851044
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40645181
46Toxoplasmosis_Homo sapiens_hsa051451.37663239
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34716812
48Tuberculosis_Homo sapiens_hsa051521.34469449
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30852577
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30077573
51Measles_Homo sapiens_hsa051621.29331635
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29032857
53Asthma_Homo sapiens_hsa053101.27808920
54Staphylococcus aureus infection_Homo sapiens_hsa051501.25327554
55Folate biosynthesis_Homo sapiens_hsa007901.24512805
56Shigellosis_Homo sapiens_hsa051311.21734657
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21174963
58ABC transporters_Homo sapiens_hsa020101.20459910
59Apoptosis_Homo sapiens_hsa042101.16291296
60Hematopoietic cell lineage_Homo sapiens_hsa046401.15266926
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12512724
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12082401
63Histidine metabolism_Homo sapiens_hsa003401.11883646
64beta-Alanine metabolism_Homo sapiens_hsa004101.07196897
65Protein digestion and absorption_Homo sapiens_hsa049741.07106157
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02786814
67Autoimmune thyroid disease_Homo sapiens_hsa053201.02077169
68Herpes simplex infection_Homo sapiens_hsa051681.00166288
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.96126485
70Biosynthesis of amino acids_Homo sapiens_hsa012300.95265172
71Arginine biosynthesis_Homo sapiens_hsa002200.95110358
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95050670
73Chemokine signaling pathway_Homo sapiens_hsa040620.92570163
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92149958
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92103507
76Amoebiasis_Homo sapiens_hsa051460.91957146
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91797382
78Fatty acid metabolism_Homo sapiens_hsa012120.90907553
79Antigen processing and presentation_Homo sapiens_hsa046120.90877763
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.90521902
81Hepatitis C_Homo sapiens_hsa051600.89898113
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89221017
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.89098914
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88197869
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85138538
86Pyruvate metabolism_Homo sapiens_hsa006200.83069936
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79059442
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75574752
89Bile secretion_Homo sapiens_hsa049760.75185743
90Primary immunodeficiency_Homo sapiens_hsa053400.75115012
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73904025
92Viral myocarditis_Homo sapiens_hsa054160.73398298
93Hepatitis B_Homo sapiens_hsa051610.72091866
94Propanoate metabolism_Homo sapiens_hsa006400.72056426
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69250577
96PPAR signaling pathway_Homo sapiens_hsa033200.68573045
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66024869
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65764234
99One carbon pool by folate_Homo sapiens_hsa006700.65750328
100Fructose and mannose metabolism_Homo sapiens_hsa000510.63440373
101Phagosome_Homo sapiens_hsa041450.61721935
102Prolactin signaling pathway_Homo sapiens_hsa049170.58755403
103Steroid biosynthesis_Homo sapiens_hsa001000.57612140
104B cell receptor signaling pathway_Homo sapiens_hsa046620.56902867
105Sphingolipid metabolism_Homo sapiens_hsa006000.55110536
106Sulfur relay system_Homo sapiens_hsa041220.51729032
107Small cell lung cancer_Homo sapiens_hsa052220.51633443
108Carbon metabolism_Homo sapiens_hsa012000.51144596
109Platelet activation_Homo sapiens_hsa046110.50566442
110Metabolic pathways_Homo sapiens_hsa011000.50544792
111Acute myeloid leukemia_Homo sapiens_hsa052210.50324901
112Lysosome_Homo sapiens_hsa041420.50092629
113Glutathione metabolism_Homo sapiens_hsa004800.49275260
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47694031
115Nitrogen metabolism_Homo sapiens_hsa009100.47529144
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.46739137
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45800286
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45778096
119Adherens junction_Homo sapiens_hsa045200.43309100
120Vitamin B6 metabolism_Homo sapiens_hsa007500.42563937
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.42373950
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41757695
123Tryptophan metabolism_Homo sapiens_hsa003800.41167651
124Sulfur metabolism_Homo sapiens_hsa009200.40444226
125Arachidonic acid metabolism_Homo sapiens_hsa005900.40396088
126Ether lipid metabolism_Homo sapiens_hsa005650.40114152
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.38831085
128Proteoglycans in cancer_Homo sapiens_hsa052050.38778568
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.37901129
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37236548
131Glycerolipid metabolism_Homo sapiens_hsa005610.36588721
132Arginine and proline metabolism_Homo sapiens_hsa003300.34936036
133Fatty acid biosynthesis_Homo sapiens_hsa000610.34545921
134Complement and coagulation cascades_Homo sapiens_hsa046100.32008928
135VEGF signaling pathway_Homo sapiens_hsa043700.31619188
136Prion diseases_Homo sapiens_hsa050200.31282320
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31006517
138Type II diabetes mellitus_Homo sapiens_hsa049300.30704107
139Chronic myeloid leukemia_Homo sapiens_hsa052200.30695881
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30679817
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30406145
142HIF-1 signaling pathway_Homo sapiens_hsa040660.30188550
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28318995
144Insulin resistance_Homo sapiens_hsa049310.27105206
145Other glycan degradation_Homo sapiens_hsa005110.26978802
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.24200217
147Glucagon signaling pathway_Homo sapiens_hsa049220.21986948
148Lysine degradation_Homo sapiens_hsa003100.19138025
149Fatty acid elongation_Homo sapiens_hsa000620.16136953
150Thyroid hormone synthesis_Homo sapiens_hsa049180.13437822
151Serotonergic synapse_Homo sapiens_hsa047260.10393309
152Ovarian steroidogenesis_Homo sapiens_hsa049130.09733589
153Nicotine addiction_Homo sapiens_hsa050330.01525895
154Selenocompound metabolism_Homo sapiens_hsa00450-0.0549002
155AMPK signaling pathway_Homo sapiens_hsa04152-0.0506741
156Phototransduction_Homo sapiens_hsa04744-0.0485068
157Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0007787

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