EXOC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.54232839
2nuclear pore organization (GO:0006999)4.15993426
3coronary vasculature morphogenesis (GO:0060977)3.52991714
4pore complex assembly (GO:0046931)3.52242178
5regulation of hippo signaling (GO:0035330)3.52239025
6glial cell proliferation (GO:0014009)3.50466585
7plasma membrane repair (GO:0001778)3.34790980
8pyrimidine nucleobase catabolic process (GO:0006208)3.23002975
9dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.12999000
10regulation of DNA endoreduplication (GO:0032875)3.10572495
11peptidyl-lysine dimethylation (GO:0018027)3.05890914
12dosage compensation (GO:0007549)3.03298226
13positive regulation of SMAD protein import into nucleus (GO:0060391)2.91786686
14cytoplasmic mRNA processing body assembly (GO:0033962)2.87594039
15mitotic sister chromatid cohesion (GO:0007064)2.87429446
16lateral sprouting from an epithelium (GO:0060601)2.84897976
17regulation of establishment of planar polarity (GO:0090175)2.79980772
18regulation of mitotic spindle organization (GO:0060236)2.78916972
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77825609
20camera-type eye morphogenesis (GO:0048593)2.77384159
21cytoskeletal anchoring at plasma membrane (GO:0007016)2.76970573
22morphogenesis of an epithelial sheet (GO:0002011)2.76476362
23clathrin coat assembly (GO:0048268)2.75068428
24NLS-bearing protein import into nucleus (GO:0006607)2.74864242
25Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.72447298
26histone H3-K36 demethylation (GO:0070544)2.72050086
27histone H2B ubiquitination (GO:0033523)2.71867708
28negative regulation of oligodendrocyte differentiation (GO:0048715)2.69052073
29hippo signaling (GO:0035329)2.67741008
30layer formation in cerebral cortex (GO:0021819)2.67290292
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.67123288
32regulation of skeletal muscle cell differentiation (GO:2001014)2.66404319
33mitotic cytokinesis (GO:0000281)2.65868803
34cerebral cortex radially oriented cell migration (GO:0021799)2.65025336
35negative regulation of DNA repair (GO:0045738)2.64388158
36inositol metabolic process (GO:0006020)2.64359452
37central nervous system projection neuron axonogenesis (GO:0021952)2.64103623
38sarcoplasmic reticulum calcium ion transport (GO:0070296)2.63550989
39neural tube development (GO:0021915)2.62888529
40mitochondrion transport along microtubule (GO:0047497)2.62579558
41establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62579558
42chondrocyte proliferation (GO:0035988)2.61774512
43pre-miRNA processing (GO:0031054)2.60981190
44establishment of nucleus localization (GO:0040023)2.60155854
45establishment of mitochondrion localization (GO:0051654)2.58961648
46spindle assembly involved in mitosis (GO:0090307)2.58086366
47regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.57671380
48cell adhesion mediated by integrin (GO:0033627)2.57609262
49biotin metabolic process (GO:0006768)2.57198899
50axon extension involved in axon guidance (GO:0048846)2.56392633
51neuron projection extension involved in neuron projection guidance (GO:1902284)2.56392633
52regulation of SMAD protein import into nucleus (GO:0060390)2.55323818
53ganglion development (GO:0061548)2.55296390
54axon extension (GO:0048675)2.53598895
55negative regulation of potassium ion transmembrane transport (GO:1901380)2.52626214
56interkinetic nuclear migration (GO:0022027)2.50692173
57Golgi to endosome transport (GO:0006895)2.50474043
58negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.48843595
59semaphorin-plexin signaling pathway (GO:0071526)2.48119377
60insulin-like growth factor receptor signaling pathway (GO:0048009)2.47752097
61embryonic viscerocranium morphogenesis (GO:0048703)2.46884860
62protein-DNA complex disassembly (GO:0032986)2.45444741
63nucleosome disassembly (GO:0006337)2.45444741
64regulation of translational fidelity (GO:0006450)2.45240244
65DNA unwinding involved in DNA replication (GO:0006268)2.45214006
66cranial nerve morphogenesis (GO:0021602)2.44713402
67establishment of spindle orientation (GO:0051294)2.44152416
68protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.44016621
69actin-myosin filament sliding (GO:0033275)2.43226651
70muscle filament sliding (GO:0030049)2.43226651
71axonal fasciculation (GO:0007413)2.42538410
72adherens junction assembly (GO:0034333)2.42159355
73membrane protein ectodomain proteolysis (GO:0006509)2.41945111
74polarized epithelial cell differentiation (GO:0030859)2.41909473
75neuronal stem cell maintenance (GO:0097150)2.41745260
76notochord development (GO:0030903)2.41532656
77histone H3-K4 trimethylation (GO:0080182)2.39483358
78cytoskeleton-dependent cytokinesis (GO:0061640)2.39202337
79paraxial mesoderm development (GO:0048339)2.39025098
80non-recombinational repair (GO:0000726)2.38813762
81double-strand break repair via nonhomologous end joining (GO:0006303)2.38813762
82phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.38530168
83negative regulation of histone methylation (GO:0031061)2.37733006
84epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37613519
85negative regulation of vascular permeability (GO:0043116)2.37452702
86regulation of posttranscriptional gene silencing (GO:0060147)2.35876109
87regulation of gene silencing by miRNA (GO:0060964)2.35876109
88regulation of gene silencing by RNA (GO:0060966)2.35876109
89negative regulation of organelle assembly (GO:1902116)2.35682095
90regulation of NFAT protein import into nucleus (GO:0051532)2.35056979
91regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.34798389
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.34056118
93positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.33842288
94COPI coating of Golgi vesicle (GO:0048205)2.33840994
95Golgi transport vesicle coating (GO:0048200)2.33840994
96collagen fibril organization (GO:0030199)2.33597313
97response to inactivity (GO:0014854)2.31985522
98actin filament-based movement (GO:0030048)2.31558084
99cell migration in hindbrain (GO:0021535)2.31080044
100syncytium formation (GO:0006949)2.30908287
101ectodermal placode formation (GO:0060788)2.30684887
102nucleobase catabolic process (GO:0046113)2.30080416
103midgut development (GO:0007494)2.29288895
104glucocorticoid receptor signaling pathway (GO:0042921)2.28558456
105dorsal/ventral axis specification (GO:0009950)2.27599233
106neuromuscular junction development (GO:0007528)2.27002148
107generation of neurons (GO:0048699)2.26754340
108regulation of protein polyubiquitination (GO:1902914)2.25982474
109cardiac myofibril assembly (GO:0055003)2.25112260
110embryonic process involved in female pregnancy (GO:0060136)2.24964620
111myotube differentiation (GO:0014902)2.23749186
112heterochromatin organization (GO:0070828)2.22587147
113actin-mediated cell contraction (GO:0070252)2.21847780
114membrane disassembly (GO:0030397)2.21276600
115nuclear envelope disassembly (GO:0051081)2.21276600
116neuron projection extension (GO:1990138)2.20957748
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.20395515
118establishment of monopolar cell polarity (GO:0061162)2.20390930
119establishment or maintenance of monopolar cell polarity (GO:0061339)2.20390930
120sister chromatid segregation (GO:0000819)2.20305711
121convergent extension (GO:0060026)2.19525550
122DNA geometric change (GO:0032392)2.19414881
123germ cell migration (GO:0008354)2.19293369
124response to lipoprotein particle (GO:0055094)2.18952019
125embryonic camera-type eye morphogenesis (GO:0048596)2.18595174
126peptidyl-lysine trimethylation (GO:0018023)2.18550521
127nucleus localization (GO:0051647)2.18545429
128hemidesmosome assembly (GO:0031581)2.18203993
129response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.17822100
130retina vasculature morphogenesis in camera-type eye (GO:0061299)2.17817998
131chromatin assembly (GO:0031497)2.17796302
132positive regulation of dendrite morphogenesis (GO:0050775)2.17750979
133negative regulation of DNA recombination (GO:0045910)2.17409588
134mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.17258452
135protein targeting to lysosome (GO:0006622)2.17185833
136establishment of protein localization to vacuole (GO:0072666)2.17185833
137protein targeting to vacuole (GO:0006623)2.17185833
138establishment of apical/basal cell polarity (GO:0035089)2.16949755
139DNA duplex unwinding (GO:0032508)2.16501515
140vesicle coating (GO:0006901)2.16406420
141regulation of centriole replication (GO:0046599)2.16232733
142myofibril assembly (GO:0030239)2.15993725
143hypotonic response (GO:0006971)2.15620647
144postsynaptic membrane organization (GO:0001941)2.15176098
145histone lysine methylation (GO:0034968)2.15148825
146mitotic nuclear envelope disassembly (GO:0007077)2.14764013
147endoplasmic reticulum organization (GO:0007029)2.14637719
148syncytium formation by plasma membrane fusion (GO:0000768)2.14628699
149regulation of neuroblast proliferation (GO:1902692)2.14617808
150histone H3-K9 demethylation (GO:0033169)2.14093951
151microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.13759293
152skeletal muscle adaptation (GO:0043501)2.13750603
153histone lysine demethylation (GO:0070076)2.12604958
154regulation of protein export from nucleus (GO:0046825)2.10565479
155positive regulation of fibroblast migration (GO:0010763)2.09462609
156regulation of RNA export from nucleus (GO:0046831)2.09326283
157histone H2A monoubiquitination (GO:0035518)2.09055776
158endodermal cell differentiation (GO:0035987)2.08636641
159positive regulation of neuroblast proliferation (GO:0002052)2.08579647
160regulation of histone H3-K9 methylation (GO:0051570)2.08208750
161myoblast fusion (GO:0007520)2.07667264
162determination of adult lifespan (GO:0008340)2.07036612
163positive regulation of signal transduction by p53 class mediator (GO:1901798)2.06792032
164regulation of spindle organization (GO:0090224)2.05773095
165histone H4-K5 acetylation (GO:0043981)2.03970377
166histone H4-K8 acetylation (GO:0043982)2.03970377
167regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.03452656
168histone H4-K16 acetylation (GO:0043984)2.03431422
169protein localization to cell surface (GO:0034394)2.03302175
170protein heterotrimerization (GO:0070208)2.03135241
171negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.02808196
172replicative senescence (GO:0090399)2.02350052
173craniofacial suture morphogenesis (GO:0097094)2.02267400
174mitotic chromosome condensation (GO:0007076)2.00633808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60220572
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.17367864
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.96162129
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.81676299
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.61187752
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.58935027
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40159193
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.97951793
9EZH2_22144423_ChIP-Seq_EOC_Human2.95547517
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69533168
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50434560
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41693263
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.37369119
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.24291237
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.15050671
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.14926203
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14789486
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02095994
19AR_21572438_ChIP-Seq_LNCaP_Human1.98695418
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.93578991
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.91753943
22TP53_16413492_ChIP-PET_HCT116_Human1.91599454
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88070921
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85610472
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84956830
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.82989688
27BRD4_25478319_ChIP-Seq_HGPS_Human1.80398038
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79503857
29DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.74707885
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71711006
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67162437
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63847695
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60312742
34* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59409513
35* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59191463
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.57319120
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56069269
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54562191
39ZNF263_19887448_ChIP-Seq_K562_Human1.51917207
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51787178
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51511063
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49094018
43TBX3_20139965_ChIP-Seq_ESCs_Mouse1.47629904
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.47022775
45TBX3_20139965_ChIP-Seq_MESCs_Mouse1.46384963
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41082922
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40749458
48* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39278700
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37124038
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36433369
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33149036
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33149036
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32451083
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31820882
55SOX9_26525672_Chip-Seq_HEART_Mouse1.30580655
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.30564792
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30500073
58* TCF4_23295773_ChIP-Seq_U87_Human1.29405844
59* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28411596
60NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27064564
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26918269
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26119495
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22892167
64TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22816738
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.22603456
66* FUS_26573619_Chip-Seq_HEK293_Human1.22557348
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.21947044
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21278589
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20888818
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20539809
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20109225
72POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.19590132
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.19026931
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.19026931
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18770814
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18691721
77* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18655026
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18609681
79* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17817234
80STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16937114
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16410474
82* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15923194
83* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15473706
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15461333
85* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15022528
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.14248310
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14232393
88TAF15_26573619_Chip-Seq_HEK293_Human1.13301508
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12768056
90MYC_22102868_ChIP-Seq_BL_Human1.11813185
91* TP53_23651856_ChIP-Seq_MEFs_Mouse1.11561051
92TFEB_21752829_ChIP-Seq_HELA_Human1.10863455
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10098678
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09461343
95CBP_20019798_ChIP-Seq_JUKART_Human1.09363999
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09363999
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08728703
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08728703
99AR_21909140_ChIP-Seq_LNCAP_Human1.07550711
100* IGF1R_20145208_ChIP-Seq_DFB_Human1.07482607
101STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07204623
102* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06604109
103* SMAD3_21741376_ChIP-Seq_EPCs_Human1.06536908
104KDM2B_26808549_Chip-Seq_DND41_Human1.04843488
105GBX2_23144817_ChIP-Seq_PC3_Human1.03027899
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02242961
107* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02180422
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.01910235
109* DROSHA_22980978_ChIP-Seq_HELA_Human1.01473320
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01319733
111* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01142835
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99733569
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99180883
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99036984
115* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98276102
116PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98268154
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97022106
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96926884
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96376557
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95583637
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95583637
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.95481909
123* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95205107
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95021164
125RXR_22108803_ChIP-Seq_LS180_Human0.94962976
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94769045
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94347053
128GATA1_22025678_ChIP-Seq_K562_Human0.94251682
129CJUN_26792858_Chip-Seq_BT549_Human0.94230242
130E2F1_18555785_Chip-Seq_ESCs_Mouse0.93800911
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93655073
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93253163
133AHR_22903824_ChIP-Seq_MCF-7_Human0.93226450
134TP53_18474530_ChIP-ChIP_U2OS_Human0.92943301
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.92765917
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92058106
137TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91443480
138* STAT3_23295773_ChIP-Seq_U87_Human0.91180931
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.91164085
140TCF7_22412390_ChIP-Seq_EML_Mouse0.89902413
141* SOX2_21211035_ChIP-Seq_LN229_Gbm0.89753977
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89730901
143* AR_19668381_ChIP-Seq_PC3_Human0.89648690
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.89413656
145CLOCK_20551151_ChIP-Seq_293T_Human0.88949175
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88551005
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87855808
148NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87753259
149BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87428441
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86783001
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85560714
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.83242079
153TP53_22127205_ChIP-Seq_IMR90_Human0.81527162
154SPI1_23127762_ChIP-Seq_K562_Human0.80875269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.80663037
2MP0008438_abnormal_cutaneous_collagen3.72718282
3MP0003705_abnormal_hypodermis_morpholog3.28476798
4MP0005623_abnormal_meninges_morphology3.01874192
5MP0010352_gastrointestinal_tract_polyps2.80932790
6MP0000733_abnormal_muscle_development2.25343669
7MP0005076_abnormal_cell_differentiation2.20853786
8MP0003646_muscle_fatigue2.19645448
9MP0005257_abnormal_intraocular_pressure2.19345994
10MP0002877_abnormal_melanocyte_morpholog2.14377146
11MP0000751_myopathy2.07625551
12MP0010307_abnormal_tumor_latency1.97856619
13MP0010234_abnormal_vibrissa_follicle1.91536957
14MP0003787_abnormal_imprinting1.90892670
15MP0003566_abnormal_cell_adhesion1.90352648
16MP0005503_abnormal_tendon_morphology1.90144543
17MP0005275_abnormal_skin_tensile1.82887151
18MP0003091_abnormal_cell_migration1.82290495
19MP0000537_abnormal_urethra_morphology1.81444777
20MP0003136_yellow_coat_color1.79936428
21MP0000383_abnormal_hair_follicle1.79044675
22MP0003283_abnormal_digestive_organ1.73830853
23MP0004145_abnormal_muscle_electrophysio1.70540867
24MP0009780_abnormal_chondrocyte_physiolo1.67277242
25MP0005171_absent_coat_pigmentation1.58000858
26MP0001958_emphysema1.57671511
27MP0000428_abnormal_craniofacial_morphol1.57543612
28MP0003385_abnormal_body_wall1.57243017
29MP0000749_muscle_degeneration1.51748114
30MP0003045_fibrosis1.50474114
31MP0004036_abnormal_muscle_relaxation1.47953119
32MP0003279_aneurysm1.44803487
33MP0010678_abnormal_skin_adnexa1.44359721
34MP0001849_ear_inflammation1.43605358
35MP0003121_genomic_imprinting1.41507152
36MP0001299_abnormal_eye_distance/1.37996469
37MP0004272_abnormal_basement_membrane1.35367385
38MP0002269_muscular_atrophy1.33097537
39MP0009384_cardiac_valve_regurgitation1.29441629
40* MP0002084_abnormal_developmental_patter1.29408913
41MP0003300_gastrointestinal_ulcer1.28986747
42MP0000371_diluted_coat_color1.26567665
43MP0003941_abnormal_skin_development1.25936815
44MP0004197_abnormal_fetal_growth/weight/1.25458220
45MP0002697_abnormal_eye_size1.22605632
46MP0003755_abnormal_palate_morphology1.22256880
47MP0003935_abnormal_craniofacial_develop1.21318592
48MP0001293_anophthalmia1.21060752
49MP0003111_abnormal_nucleus_morphology1.19590927
50MP0000579_abnormal_nail_morphology1.17785125
51MP0003937_abnormal_limbs/digits/tail_de1.17749544
52MP0003172_abnormal_lysosome_physiology1.17490631
53MP0006138_congestive_heart_failure1.17420995
54MP0002837_dystrophic_cardiac_calcinosis1.17342186
55MP0004130_abnormal_muscle_cell1.15157821
56MP0004808_abnormal_hematopoietic_stem1.14608079
57MP0000566_synostosis1.13880292
58MP0006054_spinal_hemorrhage1.13272578
59MP0001915_intracranial_hemorrhage1.13259058
60MP0002106_abnormal_muscle_physiology1.12692937
61MP0003634_abnormal_glial_cell1.09774709
62MP0008007_abnormal_cellular_replicative1.09033108
63MP0005367_renal/urinary_system_phenotyp1.06750416
64MP0000516_abnormal_urinary_system1.06750416
65MP0000432_abnormal_head_morphology1.06709779
66MP0004859_abnormal_synaptic_plasticity1.06661222
67MP0004084_abnormal_cardiac_muscle1.06449815
68MP0004270_analgesia1.06447226
69MP0005369_muscle_phenotype1.04940559
70MP0004885_abnormal_endolymph1.03762090
71MP0004233_abnormal_muscle_weight1.02608257
72MP0000467_abnormal_esophagus_morphology1.01648085
73MP0003077_abnormal_cell_cycle1.01060602
74* MP0002086_abnormal_extraembryonic_tissu1.00759262
75MP0002925_abnormal_cardiovascular_devel1.00228674
76MP0002108_abnormal_muscle_morphology1.00197333
77MP0000350_abnormal_cell_proliferation0.99936093
78MP0010368_abnormal_lymphatic_system0.99738022
79MP0001348_abnormal_lacrimal_gland0.99528396
80MP0000955_abnormal_spinal_cord0.99285574
81MP0003115_abnormal_respiratory_system0.98812957
82MP0001984_abnormal_olfaction0.98724557
83* MP0002085_abnormal_embryonic_tissue0.97848339
84MP0000778_abnormal_nervous_system0.97262477
85MP0004134_abnormal_chest_morphology0.95555437
86MP0006276_abnormal_autonomic_nervous0.92781737
87MP0003119_abnormal_digestive_system0.92631512
88MP0002092_abnormal_eye_morphology0.91891697
89MP0009672_abnormal_birth_weight0.90964829
90MP0004811_abnormal_neuron_physiology0.89032803
91MP0002114_abnormal_axial_skeleton0.88921901
92MP0002233_abnormal_nose_morphology0.87558287
93MP0005023_abnormal_wound_healing0.87346027
94MP0002152_abnormal_brain_morphology0.87342162
95MP0003942_abnormal_urinary_system0.86915147
96MP0000747_muscle_weakness0.86751080
97MP0002332_abnormal_exercise_endurance0.86696045
98MP0001672_abnormal_embryogenesis/_devel0.86643718
99MP0005380_embryogenesis_phenotype0.86643718
100MP0004087_abnormal_muscle_fiber0.86141589
101MP0000534_abnormal_ureter_morphology0.85976718
102MP0004185_abnormal_adipocyte_glucose0.85456706
103MP0003984_embryonic_growth_retardation0.84876000
104MP0002088_abnormal_embryonic_growth/wei0.84721126
105MP0002896_abnormal_bone_mineralization0.83883753
106MP0003861_abnormal_nervous_system0.83174459
107MP0000767_abnormal_smooth_muscle0.82949625
108MP0009703_decreased_birth_body0.81887706
109MP0003890_abnormal_embryonic-extraembry0.81855984
110MP0004858_abnormal_nervous_system0.81402299
111MP0005167_abnormal_blood-brain_barrier0.80952244
112MP0005620_abnormal_muscle_contractility0.80697057
113MP0009053_abnormal_anal_canal0.80212110
114MP0002109_abnormal_limb_morphology0.80029096
115MP0002177_abnormal_outer_ear0.79211960
116MP0009278_abnormal_bone_marrow0.79037540
117MP0002009_preneoplasia0.78988039
118MP0000377_abnormal_hair_follicle0.78096508
119MP0002116_abnormal_craniofacial_bone0.77914844
120MP0005391_vision/eye_phenotype0.77456583
121MP0001730_embryonic_growth_arrest0.77424166
122MP0010094_abnormal_chromosome_stability0.76800624
123MP0003632_abnormal_nervous_system0.75998468
124MP0005409_darkened_coat_color0.75928154
125MP0000762_abnormal_tongue_morphology0.75851490
126MP0008057_abnormal_DNA_replication0.75652163
127* MP0001697_abnormal_embryo_size0.75484808
128MP0000759_abnormal_skeletal_muscle0.75398684
129MP0001661_extended_life_span0.75350624
130MP0003123_paternal_imprinting0.75208703
131MP0002075_abnormal_coat/hair_pigmentati0.75089441
132MP0002081_perinatal_lethality0.74927615
133MP0005621_abnormal_cell_physiology0.73883410
134MP0005174_abnormal_tail_pigmentation0.73827896
135MP0005248_abnormal_Harderian_gland0.73797110
136MP0008770_decreased_survivor_rate0.73103793
137MP0002168_other_aberrant_phenotype0.72605277
138MP0002166_altered_tumor_susceptibility0.72604808
139MP0002111_abnormal_tail_morphology0.72554560
140MP0005508_abnormal_skeleton_morphology0.71359451
141MP0005187_abnormal_penis_morphology0.70984907
142MP0010630_abnormal_cardiac_muscle0.69922131

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.58318089
2Exercise-induced muscle cramps (HP:0003710)3.41993864
3Abnormality of the astrocytes (HP:0100707)3.38574360
4Astrocytoma (HP:0009592)3.38574360
5Hyperacusis (HP:0010780)3.17221858
6Muscle fiber inclusion bodies (HP:0100299)3.15523686
7Nemaline bodies (HP:0003798)3.12395644
8Exercise-induced myalgia (HP:0003738)3.05806173
9Ependymoma (HP:0002888)3.04863332
10Protrusio acetabuli (HP:0003179)3.02747953
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.01896890
12Renovascular hypertension (HP:0100817)2.87447103
13Centrally nucleated skeletal muscle fibers (HP:0003687)2.84778766
14Subacute progressive viral hepatitis (HP:0006572)2.84632508
15Rimmed vacuoles (HP:0003805)2.80916146
16Ankle contracture (HP:0006466)2.80835333
17Premature rupture of membranes (HP:0001788)2.77566994
18Flat cornea (HP:0007720)2.69439617
19Cerebral aneurysm (HP:0004944)2.69396165
20Distal arthrogryposis (HP:0005684)2.59659823
21Abnormality of the calcaneus (HP:0008364)2.56540042
22Glioma (HP:0009733)2.52705779
23Volvulus (HP:0002580)2.44550990
24Calcaneovalgus deformity (HP:0001848)2.39534472
25Wrist flexion contracture (HP:0001239)2.31877377
26Cervical subluxation (HP:0003308)2.30115015
27Round ear (HP:0100830)2.28547092
28Bowel diverticulosis (HP:0005222)2.26118529
29Insomnia (HP:0100785)2.23701246
30Breech presentation (HP:0001623)2.23339667
31Elfin facies (HP:0004428)2.22659178
32Hammertoe (HP:0001765)2.19088049
33Bladder diverticulum (HP:0000015)2.18075076
34Distal upper limb amyotrophy (HP:0007149)2.13634167
35Upper limb amyotrophy (HP:0009129)2.13634167
36Genu recurvatum (HP:0002816)2.13501012
37Deformed tarsal bones (HP:0008119)2.12188262
38Scapular winging (HP:0003691)2.12150463
39Spinal muscular atrophy (HP:0007269)2.11785136
40Lower limb amyotrophy (HP:0007210)2.08782356
41Hypoplastic labia majora (HP:0000059)2.08418139
42Aortic aneurysm (HP:0004942)2.07359026
43Drooling (HP:0002307)2.05409795
44Abnormality of the labia majora (HP:0012881)2.02348452
45Smooth philtrum (HP:0000319)2.00086014
46Deviation of the thumb (HP:0009603)1.99935051
47Frequent falls (HP:0002359)1.99377106
48Increased density of long bones (HP:0006392)1.98964403
49Atrophic scars (HP:0001075)1.98300644
50Mitral valve prolapse (HP:0001634)1.96748838
51Heterotopia (HP:0002282)1.95635945
52Cutaneous finger syndactyly (HP:0010554)1.95498521
53Distal lower limb amyotrophy (HP:0008944)1.94717280
54Long clavicles (HP:0000890)1.94378503
55Overriding aorta (HP:0002623)1.94129446
56Abnormality of the right ventricle (HP:0001707)1.93191682
57Dysmetric saccades (HP:0000641)1.92880380
58Aortic dissection (HP:0002647)1.92515045
59Hand muscle atrophy (HP:0009130)1.91707075
60Dilatation of the ascending aorta (HP:0005111)1.90906734
61Malignant gastrointestinal tract tumors (HP:0006749)1.90660294
62Gastrointestinal carcinoma (HP:0002672)1.90660294
63Absent frontal sinuses (HP:0002688)1.87822729
64High anterior hairline (HP:0009890)1.85603157
65Abnormality of skeletal muscle fiber size (HP:0012084)1.85366300
66Macroorchidism (HP:0000053)1.85135019
67Abnormality of the musculature of the pelvis (HP:0001469)1.84945262
68Abnormality of the hip-girdle musculature (HP:0001445)1.84945262
69Hypoplastic ischia (HP:0003175)1.84512337
70Aplasia of the phalanges of the hand (HP:0009802)1.84082964
71Aplasia involving bones of the extremities (HP:0009825)1.84082964
72Aplasia involving bones of the upper limbs (HP:0009823)1.84082964
73Hepatoblastoma (HP:0002884)1.84027998
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83909807
75Subaortic stenosis (HP:0001682)1.83713765
76Abnormality of the left ventricular outflow tract (HP:0011103)1.83713765
77Type 1 muscle fiber predominance (HP:0003803)1.83520724
78Neoplasm of the oral cavity (HP:0100649)1.83355200
79Narrow palate (HP:0000189)1.83180704
80Papillary thyroid carcinoma (HP:0002895)1.82947586
81Myoglobinuria (HP:0002913)1.82274933
82Increased variability in muscle fiber diameter (HP:0003557)1.82145756
83Natal tooth (HP:0000695)1.82059714
84Abnormality of the ischium (HP:0003174)1.81383343
85Obsessive-compulsive behavior (HP:0000722)1.81294000
86Abnormality of the diencephalon (HP:0010662)1.81082820
87Deep philtrum (HP:0002002)1.80653797
88Neonatal short-limb short stature (HP:0008921)1.80498559
89Ankyloglossia (HP:0010296)1.79939777
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79121133
91Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78907628
92Fibrous tissue neoplasm (HP:0012316)1.78646349
93Spinal rigidity (HP:0003306)1.78472721
94Pointed chin (HP:0000307)1.78016221
95Cutaneous syndactyly (HP:0012725)1.77799869
96Bell-shaped thorax (HP:0001591)1.77791017
97Vertebral arch anomaly (HP:0008438)1.77771279
98Partial agenesis of the corpus callosum (HP:0001338)1.77438081
99Difficulty running (HP:0009046)1.76873849
100Proximal placement of thumb (HP:0009623)1.76270732
101Blue irides (HP:0000635)1.74971133
102Colon cancer (HP:0003003)1.74214197
103Bronchomalacia (HP:0002780)1.74203531
104Excessive salivation (HP:0003781)1.74126386
105Neoplasm of the adrenal cortex (HP:0100641)1.74037096
106Renal duplication (HP:0000075)1.73865638
107Overgrowth (HP:0001548)1.72833500
108Fibroma (HP:0010614)1.72427696
109Hypoplasia of the maxilla (HP:0000327)1.71968838
110Pheochromocytoma (HP:0002666)1.71877294
111Broad thumb (HP:0011304)1.71668886
112Cubitus valgus (HP:0002967)1.70174673
113Increased nuchal translucency (HP:0010880)1.70156858
114Missing ribs (HP:0000921)1.69837834
115Uterine leiomyosarcoma (HP:0002891)1.69473175
116Leiomyosarcoma (HP:0100243)1.69473175
117High pitched voice (HP:0001620)1.69279936
118Aneurysm (HP:0002617)1.69112730
119Steppage gait (HP:0003376)1.68755846
120Transitional cell carcinoma of the bladder (HP:0006740)1.68545734
121Mildly elevated creatine phosphokinase (HP:0008180)1.68473807
122Long eyelashes (HP:0000527)1.68177952
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68069688
124Vascular tortuosity (HP:0004948)1.67840572
125Biliary tract neoplasm (HP:0100574)1.66808833
126Limb-girdle muscle weakness (HP:0003325)1.66380596
127Difficulty climbing stairs (HP:0003551)1.65306957
128Short 4th metacarpal (HP:0010044)1.64825643
129Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64825643
130Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64350363
131Vertebral hypoplasia (HP:0008417)1.64350363
132Increased connective tissue (HP:0009025)1.62982929
133Sandal gap (HP:0001852)1.62330311
134Buphthalmos (HP:0000557)1.62217679
135Bladder carcinoma (HP:0002862)1.62029303
136Bladder neoplasm (HP:0009725)1.62029303
137Broad ribs (HP:0000885)1.61693544
138Abnormality of the lower motor neuron (HP:0002366)1.61684856
139Broad palm (HP:0001169)1.60901433
140Broad metatarsal (HP:0001783)1.60759568
141Wormian bones (HP:0002645)1.60648541
142Prostate neoplasm (HP:0100787)1.60619370
143Hyporeflexia of lower limbs (HP:0002600)1.59321335
144Ulnar deviation of the wrist (HP:0003049)1.58847352
145Asymmetry of the thorax (HP:0001555)1.58730420
146Soft skin (HP:0000977)1.58258419
147Cortical dysplasia (HP:0002539)1.58094195
148Urethral obstruction (HP:0000796)1.56583507
149Benign neoplasm of the central nervous system (HP:0100835)1.56571693
150Shoulder girdle muscle weakness (HP:0003547)1.56407222
151Tubulointerstitial nephritis (HP:0001970)1.54865049
152Arterial tortuosity (HP:0005116)1.54439232
153Broad long bones (HP:0005622)1.54414907
154Abnormality of dentin (HP:0010299)1.54142130
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.53020236
156Abnormality of the fingertips (HP:0001211)1.52890066
157Termporal pattern (HP:0011008)1.52803837
158Insidious onset (HP:0003587)1.52803837
159Broad phalanges of the hand (HP:0009768)1.52214773
160Bowel incontinence (HP:0002607)1.52059032
161Chin dimple (HP:0010751)1.51736403
162Tracheomalacia (HP:0002779)1.51077497
163Pelvic girdle muscle weakness (HP:0003749)1.50375075
164Prominent nose (HP:0000448)1.49879825
165Muscle fiber splitting (HP:0003555)1.49720323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.25929359
2TTN3.40925406
3OBSCN3.30735886
4PKN23.03968690
5SCYL22.99305455
6EEF2K2.98021270
7PDGFRA2.39037132
8DDR22.30632020
9BRD41.92983637
10CDC71.81661468
11CAMK1D1.76266717
12PBK1.72629670
13EPHA21.71464953
14PAK61.69964042
15RIPK11.69562881
16MAP4K21.67567766
17STK391.66817296
18PTK61.62376948
19CCNB11.59162160
20FRK1.58308208
21PINK11.57698224
22LATS11.56416306
23CAMK1G1.50774249
24EPHA31.49514622
25PHKG21.49410426
26PHKG11.49410426
27STK38L1.45735952
28PASK1.37855154
29PIK3CG1.36047732
30TRIB31.35662196
31PLK21.34784740
32FGFR11.30746151
33FER1.29477462
34ERBB31.28241711
35FGFR21.23413458
36MTOR1.21171231
37PDK21.19659293
38EPHB21.16988394
39NEK11.16907604
40CLK11.16249198
41ZAK1.15958677
42PAK21.14350179
43BMX1.14334394
44CDK61.13105869
45KSR21.11391936
46RET1.05719042
47MAP3K71.03766149
48KSR11.01834577
49PAK31.01291974
50RPS6KB21.00893735
51TIE11.00339185
52CDK190.97698435
53BCR0.96928231
54NEK20.96243133
55MAP3K20.95469586
56DMPK0.95467127
57PRKCH0.94775765
58AKT30.92866978
59MARK20.91798848
60ATR0.91184983
61WNK10.90583016
62EPHA40.88957205
63NEK60.88343460
64SIK10.87961665
65CASK0.87751099
66ALK0.87488514
67FGFR30.86771247
68PDGFRB0.86382164
69ROCK10.85962066
70WNK40.85807238
71CSNK1D0.84279025
72FLT30.83891979
73PAK40.82845407
74TRPM70.82837556
75PLK30.82634166
76MAP3K40.82473701
77MET0.82329959
78CHEK10.79951811
79LATS20.78857550
80PTK20.77413213
81LMTK20.76616352
82STK30.76053397
83EPHB10.75820993
84SIK20.75108925
85STK240.74166331
86DYRK1B0.71162276
87ATM0.70000792
88RPS6KA20.69047327
89PNCK0.68677210
90CHUK0.67885665
91BMPR1B0.67258737
92CAMKK10.66839809
93SGK30.66727070
94AKT20.64389711
95RPS6KB10.63548135
96MKNK10.62962744
97MAP2K40.61853889
98TYRO30.60396986
99CDK20.60321980
100NTRK10.59826535
101ROCK20.59678755
102CDK90.59453504
103ERBB40.59064875
104SGK20.58980908
105LRRK20.58782333
106CAMK40.58520495
107PRKAA10.58310660
108AKT10.58281253
109MAPKAPK50.57732213
110STK100.57698338
111MAP3K90.57645639
112ICK0.57262150
113PRKDC0.56975220
114SGK10.56965866
115PRKD30.56871519
116AURKB0.55391445
117CHEK20.54574007
118TTK0.54224013
119INSR0.53264387
120MAPK80.52405969
121PRKD20.51891596
122DYRK1A0.51698325
123MAP3K100.48636712
124PRKAA20.48451901
125CSNK1A1L0.48414107
126SRPK10.47926157
127SGK2230.47887109
128SGK4940.47887109
129NTRK20.47159718
130CDK10.46872446
131TAOK30.46622093
132MAPK110.46562542
133TNIK0.46362100
134MAPK100.46178427
135ERBB20.45808213
136CAMK10.45799780
137MARK10.45547321
138FGR0.44498412
139PLK10.44368238
140MAPK140.44014212
141MAP3K80.43887335
142NTRK30.43879180
143NEK90.43224375
144FGFR40.42927884
145MAP3K60.42169182
146GSK3B0.41659904

Predicted pathways (KEGG)

RankGene SetZ-score
1Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79683761
2MicroRNAs in cancer_Homo sapiens_hsa052061.78685555
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68244394
4Focal adhesion_Homo sapiens_hsa045101.67970966
5Adherens junction_Homo sapiens_hsa045201.58335194
6mTOR signaling pathway_Homo sapiens_hsa041501.56363053
7ECM-receptor interaction_Homo sapiens_hsa045121.55614143
8Chronic myeloid leukemia_Homo sapiens_hsa052201.54289858
9Endometrial cancer_Homo sapiens_hsa052131.54126233
10Proteoglycans in cancer_Homo sapiens_hsa052051.50377982
11Dilated cardiomyopathy_Homo sapiens_hsa054141.49383259
12Glioma_Homo sapiens_hsa052141.49043301
13Colorectal cancer_Homo sapiens_hsa052101.47682312
14Viral myocarditis_Homo sapiens_hsa054161.46608569
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40002173
16Small cell lung cancer_Homo sapiens_hsa052221.39429727
17p53 signaling pathway_Homo sapiens_hsa041151.35972032
18Hippo signaling pathway_Homo sapiens_hsa043901.35051138
19Cell cycle_Homo sapiens_hsa041101.32606941
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32515188
21Biosynthesis of amino acids_Homo sapiens_hsa012301.25819052
22Viral carcinogenesis_Homo sapiens_hsa052031.23760338
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20714758
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20449606
25Pentose phosphate pathway_Homo sapiens_hsa000301.17675206
26Axon guidance_Homo sapiens_hsa043601.17169388
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16793746
28Melanoma_Homo sapiens_hsa052181.16586552
29Type II diabetes mellitus_Homo sapiens_hsa049301.14557671
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13889542
31ErbB signaling pathway_Homo sapiens_hsa040121.11246576
32Renal cell carcinoma_Homo sapiens_hsa052111.10426948
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09583653
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.09464248
35Fatty acid biosynthesis_Homo sapiens_hsa000611.09340225
36Systemic lupus erythematosus_Homo sapiens_hsa053221.09182573
37Non-homologous end-joining_Homo sapiens_hsa034501.08349874
38* Tight junction_Homo sapiens_hsa045301.08100027
39Prostate cancer_Homo sapiens_hsa052151.07624174
40Bladder cancer_Homo sapiens_hsa052191.07407664
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05861128
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04873089
43Arginine biosynthesis_Homo sapiens_hsa002201.04480495
44Pancreatic cancer_Homo sapiens_hsa052121.04081085
45Non-small cell lung cancer_Homo sapiens_hsa052231.03949880
46Basal cell carcinoma_Homo sapiens_hsa052171.03810137
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02700946
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01773008
49HTLV-I infection_Homo sapiens_hsa051661.00942207
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.98548283
51Notch signaling pathway_Homo sapiens_hsa043300.98073462
52Thyroid hormone synthesis_Homo sapiens_hsa049180.97773998
53Estrogen signaling pathway_Homo sapiens_hsa049150.96733034
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.96258906
55Amoebiasis_Homo sapiens_hsa051460.95696621
56Choline metabolism in cancer_Homo sapiens_hsa052310.95515431
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94228518
58Wnt signaling pathway_Homo sapiens_hsa043100.91413383
59TGF-beta signaling pathway_Homo sapiens_hsa043500.90982350
60Long-term depression_Homo sapiens_hsa047300.90148197
61Alcoholism_Homo sapiens_hsa050340.89905006
62Melanogenesis_Homo sapiens_hsa049160.89874801
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89209978
64Carbon metabolism_Homo sapiens_hsa012000.88361230
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86695726
66Rap1 signaling pathway_Homo sapiens_hsa040150.86250937
67Pathways in cancer_Homo sapiens_hsa052000.86246459
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85874208
69Lysine degradation_Homo sapiens_hsa003100.85780948
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85057037
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84088014
72Platelet activation_Homo sapiens_hsa046110.84079676
73Glucagon signaling pathway_Homo sapiens_hsa049220.83458600
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83133068
75Oxytocin signaling pathway_Homo sapiens_hsa049210.82134226
76Gap junction_Homo sapiens_hsa045400.81305121
77FoxO signaling pathway_Homo sapiens_hsa040680.80809957
78Prolactin signaling pathway_Homo sapiens_hsa049170.80592487
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78851760
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78717827
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77811882
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77718393
83Circadian rhythm_Homo sapiens_hsa047100.77490184
84GnRH signaling pathway_Homo sapiens_hsa049120.76324476
85Shigellosis_Homo sapiens_hsa051310.76298992
86VEGF signaling pathway_Homo sapiens_hsa043700.76055468
87HIF-1 signaling pathway_Homo sapiens_hsa040660.75058008
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74843883
89Hedgehog signaling pathway_Homo sapiens_hsa043400.74774694
90Hepatitis B_Homo sapiens_hsa051610.74363109
91Apoptosis_Homo sapiens_hsa042100.73880123
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73662411
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.73368545
94Dorso-ventral axis formation_Homo sapiens_hsa043200.71826221
95Toxoplasmosis_Homo sapiens_hsa051450.71745032
96Oocyte meiosis_Homo sapiens_hsa041140.71471560
97mRNA surveillance pathway_Homo sapiens_hsa030150.70423952
98Insulin signaling pathway_Homo sapiens_hsa049100.69677390
99Cholinergic synapse_Homo sapiens_hsa047250.68971429
100MAPK signaling pathway_Homo sapiens_hsa040100.67848270
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66352966
102Inositol phosphate metabolism_Homo sapiens_hsa005620.66221200
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65426049
104Endocytosis_Homo sapiens_hsa041440.64412398
105Fatty acid metabolism_Homo sapiens_hsa012120.64360089
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64044815
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62988841
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62415982
109Renin secretion_Homo sapiens_hsa049240.62014799
110Thyroid cancer_Homo sapiens_hsa052160.61829077
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61760399
112Circadian entrainment_Homo sapiens_hsa047130.61658200
113RNA transport_Homo sapiens_hsa030130.61509021
114AMPK signaling pathway_Homo sapiens_hsa041520.60864833
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60531112
116Long-term potentiation_Homo sapiens_hsa047200.60397287
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60079011
118TNF signaling pathway_Homo sapiens_hsa046680.59204749
119B cell receptor signaling pathway_Homo sapiens_hsa046620.58002503
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57084801
121Protein digestion and absorption_Homo sapiens_hsa049740.56932086
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56377557
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55633734
124Glutamatergic synapse_Homo sapiens_hsa047240.55091037
125Calcium signaling pathway_Homo sapiens_hsa040200.52974925
126Fanconi anemia pathway_Homo sapiens_hsa034600.52386277
127Salivary secretion_Homo sapiens_hsa049700.51823465
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50758348

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