EXOC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.01989236
2response to pheromone (GO:0019236)3.56175163
3negative regulation of cell killing (GO:0031342)3.53744351
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53744351
5nuclear pore complex assembly (GO:0051292)3.44802826
6nuclear pore organization (GO:0006999)3.33236805
7positive regulation by symbiont of host defense response (GO:0052509)3.30520457
8modulation by symbiont of host defense response (GO:0052031)3.30520457
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30520457
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30520457
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.30520457
12modulation by symbiont of host immune response (GO:0052553)3.30520457
13mitotic sister chromatid cohesion (GO:0007064)3.26900433
14negative regulation of neurotransmitter secretion (GO:0046929)3.26780713
15CENP-A containing nucleosome assembly (GO:0034080)3.24195304
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21108381
17chromatin remodeling at centromere (GO:0031055)3.17159701
18presynaptic membrane assembly (GO:0097105)3.09888504
19establishment of integrated proviral latency (GO:0075713)3.07570710
20regulation of development, heterochronic (GO:0040034)3.05370333
21central nervous system projection neuron axonogenesis (GO:0021952)2.95734777
22DNA ligation (GO:0006266)2.94523573
23negative regulation of neurotransmitter transport (GO:0051589)2.93514017
24axonal fasciculation (GO:0007413)2.91554608
25neuron cell-cell adhesion (GO:0007158)2.90142666
26regulation of centriole replication (GO:0046599)2.82947240
27lipopolysaccharide biosynthetic process (GO:0009103)2.79574258
28nerve growth factor signaling pathway (GO:0038180)2.78932021
29protein localization to chromosome, centromeric region (GO:0071459)2.78632359
30ganglion development (GO:0061548)2.78293057
31dendrite morphogenesis (GO:0048813)2.77986766
32dopaminergic neuron differentiation (GO:0071542)2.77210999
33cerebral cortex radially oriented cell migration (GO:0021799)2.76210266
34sister chromatid segregation (GO:0000819)2.75100892
35mitotic spindle organization (GO:0007052)2.74538934
36central nervous system neuron axonogenesis (GO:0021955)2.72272859
37dendritic spine morphogenesis (GO:0060997)2.72064083
38positive regulation of oligodendrocyte differentiation (GO:0048714)2.71501100
39olfactory bulb development (GO:0021772)2.71487363
40neuron recognition (GO:0008038)2.69288371
41protein localization to kinetochore (GO:0034501)2.68462983
42resolution of meiotic recombination intermediates (GO:0000712)2.68447418
43intraciliary transport (GO:0042073)2.67534794
44clathrin coat assembly (GO:0048268)2.67203929
45microtubule depolymerization (GO:0007019)2.66387663
46DNA replication-independent nucleosome organization (GO:0034724)2.64353680
47DNA replication-independent nucleosome assembly (GO:0006336)2.64353680
48negative regulation of axon guidance (GO:1902668)2.63937757
49DNA double-strand break processing (GO:0000729)2.63796164
50microglial cell activation (GO:0001774)2.63450171
51protein localization to chromosome (GO:0034502)2.63344648
52DNA topological change (GO:0006265)2.62945735
53double-strand break repair via nonhomologous end joining (GO:0006303)2.62890162
54non-recombinational repair (GO:0000726)2.62890162
55histone exchange (GO:0043486)2.62137029
56kinetochore organization (GO:0051383)2.61916790
57organelle disassembly (GO:1903008)2.60940359
58forebrain neuron differentiation (GO:0021879)2.60915363
59spindle checkpoint (GO:0031577)2.60904693
60neural tube formation (GO:0001841)2.60233035
61neutrophil activation involved in immune response (GO:0002283)2.59949376
62negative regulation of DNA recombination (GO:0045910)2.58536049
63apical protein localization (GO:0045176)2.58466820
64ribonucleoprotein complex disassembly (GO:0032988)2.58461253
65neuronal stem cell maintenance (GO:0097150)2.58448349
66regulation of timing of cell differentiation (GO:0048505)2.58142283
67presynaptic membrane organization (GO:0097090)2.55380549
68startle response (GO:0001964)2.54462735
69pore complex assembly (GO:0046931)2.53218451
70cerebral cortex cell migration (GO:0021795)2.52359117
71calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51729657
72mitotic chromosome condensation (GO:0007076)2.51413043
73regulation of pigment cell differentiation (GO:0050932)2.49783174
74postsynaptic membrane organization (GO:0001941)2.49283869
75asymmetric protein localization (GO:0008105)2.49048802
76negative regulation of oligodendrocyte differentiation (GO:0048715)2.48298716
77ATP-dependent chromatin remodeling (GO:0043044)2.47915610
78mitotic spindle checkpoint (GO:0071174)2.47185284
79spermatid nucleus differentiation (GO:0007289)2.46279106
80regulation of sister chromatid cohesion (GO:0007063)2.46001092
81neuron fate determination (GO:0048664)2.44523626
82lipopolysaccharide metabolic process (GO:0008653)2.44306921
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43997251
84embryonic foregut morphogenesis (GO:0048617)2.43326639
85negative chemotaxis (GO:0050919)2.42490410
86response to host immune response (GO:0052572)2.41342253
87response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41342253
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.41269831
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.41269831
90negative regulation of mitotic sister chromatid segregation (GO:0033048)2.41269831
91negative regulation of mitotic sister chromatid separation (GO:2000816)2.41269831
92negative regulation of sister chromatid segregation (GO:0033046)2.41269831
93T-helper 1 type immune response (GO:0042088)2.39787107
94mitotic spindle assembly checkpoint (GO:0007094)2.39754725
95cytoplasmic mRNA processing body assembly (GO:0033962)2.39468731
96Rap protein signal transduction (GO:0032486)2.38888686
97gastrulation with mouth forming second (GO:0001702)2.38879293
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.38724027
99limb bud formation (GO:0060174)2.37656171
100pyrimidine nucleobase catabolic process (GO:0006208)2.36515519
101spindle assembly checkpoint (GO:0071173)2.36217585
102DNA damage response, detection of DNA damage (GO:0042769)2.36213784
103G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.35575859
104regulation of growth hormone secretion (GO:0060123)2.34887075
105mitotic metaphase plate congression (GO:0007080)2.34320841
106negative regulation of meiosis (GO:0045835)2.34039115
107metaphase plate congression (GO:0051310)2.34037310
108negative regulation of chromosome segregation (GO:0051985)2.33808844
109regulation of chromosome segregation (GO:0051983)2.33559790
110regulation of axon guidance (GO:1902667)2.31272058
111retinal ganglion cell axon guidance (GO:0031290)2.30770244
112anatomical structure arrangement (GO:0048532)2.30658413
113retina vasculature morphogenesis in camera-type eye (GO:0061299)2.29512777
114morphogenesis of an epithelial sheet (GO:0002011)2.29367201
115negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.29067004
116negative regulation of T-helper cell differentiation (GO:0045623)2.29067004
117mRNA splice site selection (GO:0006376)2.29042715
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.28915826
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.28915826
120regulation of sister chromatid segregation (GO:0033045)2.28751607
121regulation of mitotic sister chromatid separation (GO:0010965)2.28751607
122regulation of mitotic sister chromatid segregation (GO:0033047)2.28751607
123mitotic sister chromatid segregation (GO:0000070)2.27483304
124regulation of oligodendrocyte differentiation (GO:0048713)2.27479882
125nonmotile primary cilium assembly (GO:0035058)2.26411664
126negative regulation of axon extension (GO:0030517)2.26142129
127B cell homeostasis (GO:0001782)2.25726192
128regulation of meiosis I (GO:0060631)2.25724954
129establishment of viral latency (GO:0019043)2.24904815
130axon extension (GO:0048675)2.24569015
131regulation of germinal center formation (GO:0002634)2.24501239
132positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.23908584
133regulation of centrosome cycle (GO:0046605)2.22356675
134regulation of chemokine-mediated signaling pathway (GO:0070099)2.21204763
135cranial nerve morphogenesis (GO:0021602)2.20129782
136inner ear receptor cell development (GO:0060119)2.16067584
137righting reflex (GO:0060013)2.14835549
138vesicle fusion (GO:0006906)2.13700600
139neuron maturation (GO:0042551)2.13533508
140regulation of synapse assembly (GO:0051963)2.12461417
141neuron projection extension involved in neuron projection guidance (GO:1902284)2.12326933
142axon extension involved in axon guidance (GO:0048846)2.12326933
143regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.12248481
144phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.12140188
145SMAD protein complex assembly (GO:0007183)2.12045589
146developmental pigmentation (GO:0048066)2.11998365
147regulation of dendritic spine development (GO:0060998)2.11989338
148negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.11852823
149regulation of axon extension involved in axon guidance (GO:0048841)2.11788393
150negative regulation of osteoblast proliferation (GO:0033689)2.11566936
151ionotropic glutamate receptor signaling pathway (GO:0035235)2.11147522
152response to host (GO:0075136)2.10138111
153response to host defenses (GO:0052200)2.10138111
154response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.10138111
155negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.09737600
156regulation of fibroblast apoptotic process (GO:2000269)2.06930294
157nucleobase catabolic process (GO:0046113)2.06226237
158regulation of filopodium assembly (GO:0051489)2.05353108
159regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.05336987
160positive regulation of dendritic spine morphogenesis (GO:0061003)2.05302659
161facial nerve structural organization (GO:0021612)2.05187985
162establishment of nucleus localization (GO:0040023)2.04988889
163neuron projection extension (GO:1990138)2.04230337
164regulation of neuron migration (GO:2001222)2.04042019
165regulation of NIK/NF-kappaB signaling (GO:1901222)2.02853020
166regulation of DNA endoreduplication (GO:0032875)2.02160488
167negative regulation of B cell proliferation (GO:0030889)2.01874874
168negative regulation of exocytosis (GO:0045920)2.01557217
169negative regulation of alpha-beta T cell activation (GO:0046636)2.00784334
170positive regulation of glial cell differentiation (GO:0045687)1.97807651
171layer formation in cerebral cortex (GO:0021819)1.97121689
172positive regulation of synapse assembly (GO:0051965)1.96924176
173macrophage activation involved in immune response (GO:0002281)1.96698814
174negative regulation of translation involved in gene silencing by miRNA (GO:0035278)1.96676390
175negative regulation of translation, ncRNA-mediated (GO:0040033)1.96676390
176regulation of translation, ncRNA-mediated (GO:0045974)1.96676390
177membrane assembly (GO:0071709)1.96616649
178response to nerve growth factor (GO:1990089)1.96488497
179cellular response to nerve growth factor stimulus (GO:1990090)1.96488497
180Rac protein signal transduction (GO:0016601)1.96069306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.16939537
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.64484111
3GBX2_23144817_ChIP-Seq_PC3_Human3.28843112
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.07041737
5E2F7_22180533_ChIP-Seq_HELA_Human2.79802366
6EZH2_22144423_ChIP-Seq_EOC_Human2.63357834
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58057107
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54543149
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.53663337
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42583406
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38892990
12TAF15_26573619_Chip-Seq_HEK293_Human2.35860425
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.17042761
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13420852
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11530618
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.07774262
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07147211
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.03219121
19ZNF274_21170338_ChIP-Seq_K562_Hela1.97046639
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95573174
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91096624
22P300_19829295_ChIP-Seq_ESCs_Human1.89734462
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88549066
24FUS_26573619_Chip-Seq_HEK293_Human1.86944992
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.86111051
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85989804
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83893606
28* AR_21572438_ChIP-Seq_LNCaP_Human1.83142131
29IGF1R_20145208_ChIP-Seq_DFB_Human1.82274880
30AR_21909140_ChIP-Seq_LNCAP_Human1.81371304
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70963196
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67963822
33ELK1_19687146_ChIP-ChIP_HELA_Human1.67803906
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67092213
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66125162
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65717989
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63747911
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63192351
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62768070
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61112759
41ER_23166858_ChIP-Seq_MCF-7_Human1.60010442
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.59494198
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58430913
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.55015601
45EWS_26573619_Chip-Seq_HEK293_Human1.53099063
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52762346
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52279332
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51218168
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50895112
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49664399
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48209414
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47427339
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46760354
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45720955
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44671520
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.44345624
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44303716
58* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43064612
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.41921897
60SMAD4_21799915_ChIP-Seq_A2780_Human1.41907067
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.41123879
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40987146
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.40353761
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.39713977
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36914302
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.36654888
67TP53_16413492_ChIP-PET_HCT116_Human1.36619281
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34999518
69SOX9_26525672_Chip-Seq_HEART_Mouse1.32477822
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32442148
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31900068
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31900068
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31367647
74* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31035562
75* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30827073
76* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.30570591
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30545511
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30022248
79TP53_18474530_ChIP-ChIP_U2OS_Human1.29316590
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28157689
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25690569
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.25283881
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24466521
84VDR_22108803_ChIP-Seq_LS180_Human1.24193184
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23985601
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23985601
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23608415
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23585596
89AR_25329375_ChIP-Seq_VCAP_Human1.22655744
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22129410
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.21772366
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21049857
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20563001
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.20450748
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20356582
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19776463
97JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19316340
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19162554
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.19059369
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18861569
101RXR_22108803_ChIP-Seq_LS180_Human1.17815953
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17558664
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17411929
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16869502
105P53_22387025_ChIP-Seq_ESCs_Mouse1.16506591
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15321416
107RNF2_27304074_Chip-Seq_NSC_Mouse1.15243946
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.15151427
109STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14900725
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14480092
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.14367477
112STAT3_23295773_ChIP-Seq_U87_Human1.14016821
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13901620
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13435064
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.11971179
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11604755
117NANOG_16153702_ChIP-ChIP_HESCs_Human1.11343506
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.10868823
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10725634
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09732544
121* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09235236
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08980566
123AHR_22903824_ChIP-Seq_MCF-7_Human1.07846664
124JUN_21703547_ChIP-Seq_K562_Human1.07128152
125BCAT_22108803_ChIP-Seq_LS180_Human1.05646814
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05619153
127RUNX_20019798_ChIP-Seq_JUKART_Human1.05578600
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04872838
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04566855
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04018416
131* RUNX2_22187159_ChIP-Seq_PCA_Human1.03970201
132EZH2_27294783_Chip-Seq_NPCs_Mouse1.03076850
133CBP_20019798_ChIP-Seq_JUKART_Human1.02547586
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02547586
135SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02224738
136REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01860494
137MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01383885
138FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01011460
139EGR1_19374776_ChIP-ChIP_THP-1_Human1.00957110
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00056363
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99337856
142SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98765969
143CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98444594
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98075357
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96851933
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94620744
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94107064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.42227130
2MP0003880_abnormal_central_pattern2.78164023
3MP0000778_abnormal_nervous_system2.48002086
4MP0002009_preneoplasia2.37079686
5MP0005171_absent_coat_pigmentation1.98396461
6MP0005248_abnormal_Harderian_gland1.90009586
7MP0004270_analgesia1.87197706
8MP0000537_abnormal_urethra_morphology1.84427658
9MP0001293_anophthalmia1.83602062
10MP0001188_hyperpigmentation1.74254354
11MP0001299_abnormal_eye_distance/1.72707338
12MP0005499_abnormal_olfactory_system1.72345385
13MP0005394_taste/olfaction_phenotype1.72345385
14MP0002697_abnormal_eye_size1.71819615
15MP0008789_abnormal_olfactory_epithelium1.68810742
16MP0002233_abnormal_nose_morphology1.65951630
17MP0002234_abnormal_pharynx_morphology1.64669622
18MP0003122_maternal_imprinting1.64110876
19MP0010094_abnormal_chromosome_stability1.63739923
20MP0003091_abnormal_cell_migration1.62852641
21MP0000383_abnormal_hair_follicle1.62784199
22MP0002751_abnormal_autonomic_nervous1.61751745
23MP0003303_peritoneal_inflammation1.60461377
24MP0008058_abnormal_DNA_repair1.60139742
25MP0005409_darkened_coat_color1.59477806
26MP0010678_abnormal_skin_adnexa1.56252800
27MP0004859_abnormal_synaptic_plasticity1.55525188
28MP0001348_abnormal_lacrimal_gland1.54820635
29MP0004742_abnormal_vestibular_system1.54768293
30MP0010386_abnormal_urinary_bladder1.53221372
31MP0001286_abnormal_eye_development1.51420724
32MP0008438_abnormal_cutaneous_collagen1.48265691
33MP0008932_abnormal_embryonic_tissue1.48095385
34MP0006276_abnormal_autonomic_nervous1.46824076
35MP0010030_abnormal_orbit_morphology1.45129991
36MP0003385_abnormal_body_wall1.44657319
37MP0003136_yellow_coat_color1.43343721
38MP0002102_abnormal_ear_morphology1.43219058
39MP0003119_abnormal_digestive_system1.42724050
40MP0003937_abnormal_limbs/digits/tail_de1.39215934
41MP0002084_abnormal_developmental_patter1.37484668
42MP0001984_abnormal_olfaction1.33835131
43MP0000428_abnormal_craniofacial_morphol1.32693449
44MP0003300_gastrointestinal_ulcer1.31833080
45MP0009697_abnormal_copulation1.31444148
46MP0003635_abnormal_synaptic_transmissio1.29731601
47MP0008877_abnormal_DNA_methylation1.29575767
48MP0000015_abnormal_ear_pigmentation1.29098276
49MP0004957_abnormal_blastocyst_morpholog1.28519075
50MP0006292_abnormal_olfactory_placode1.28442180
51MP0002092_abnormal_eye_morphology1.26893219
52MP0001486_abnormal_startle_reflex1.26372551
53MP0002184_abnormal_innervation1.26225692
54MP0003077_abnormal_cell_cycle1.26156237
55MP0004924_abnormal_behavior1.25197009
56MP0005386_behavior/neurological_phenoty1.25197009
57MP0000920_abnormal_myelination1.23878886
58MP0006072_abnormal_retinal_apoptosis1.23874154
59MP0003787_abnormal_imprinting1.23502486
60MP0010352_gastrointestinal_tract_polyps1.22940011
61MP0003221_abnormal_cardiomyocyte_apopto1.22722709
62MP0006054_spinal_hemorrhage1.22400865
63MP0000465_gastrointestinal_hemorrhage1.21381758
64MP0000049_abnormal_middle_ear1.20559958
65MP0002938_white_spotting1.20553651
66MP0003941_abnormal_skin_development1.20451758
67MP0002085_abnormal_embryonic_tissue1.18587516
68MP0002177_abnormal_outer_ear1.17624944
69MP0004134_abnormal_chest_morphology1.17094374
70MP0001958_emphysema1.16914456
71MP0002063_abnormal_learning/memory/cond1.16786371
72MP0004197_abnormal_fetal_growth/weight/1.16643888
73MP0010234_abnormal_vibrissa_follicle1.16090351
74MP0005174_abnormal_tail_pigmentation1.12000601
75MP0003890_abnormal_embryonic-extraembry1.11850143
76MP0002166_altered_tumor_susceptibility1.11419153
77MP0003315_abnormal_perineum_morphology1.11098095
78MP0003567_abnormal_fetal_cardiomyocyte1.09094012
79MP0005391_vision/eye_phenotype1.08751120
80MP0005671_abnormal_response_to1.06610950
81MP0005623_abnormal_meninges_morphology1.05823929
82MP0005187_abnormal_penis_morphology1.05271843
83MP0002067_abnormal_sensory_capabilities1.04646317
84MP0002822_catalepsy1.04570177
85MP0003183_abnormal_peptide_metabolism1.03823696
86MP0005503_abnormal_tendon_morphology1.03271636
87MP0002277_abnormal_respiratory_mucosa1.03234760
88MP0010368_abnormal_lymphatic_system1.03203318
89MP0002006_tumorigenesis1.02737455
90MP0009703_decreased_birth_body1.02395943
91MP0002282_abnormal_trachea_morphology1.01359517
92MP0005000_abnormal_immune_tolerance0.99667795
93MP0001177_atelectasis0.99302959
94MP0005076_abnormal_cell_differentiation0.99208483
95MP0003111_abnormal_nucleus_morphology0.98496597
96MP0001672_abnormal_embryogenesis/_devel0.98168717
97MP0005380_embryogenesis_phenotype0.98168717
98MP0005253_abnormal_eye_physiology0.97641466
99MP0004133_heterotaxia0.97317177
100MP0000372_irregular_coat_pigmentation0.97174633
101MP0000631_abnormal_neuroendocrine_gland0.96939792
102MP0000566_synostosis0.96519495
103MP0005646_abnormal_pituitary_gland0.94755073
104MP0003121_genomic_imprinting0.94535166
105MP0009672_abnormal_birth_weight0.94150108
106MP0004811_abnormal_neuron_physiology0.93267389
107MP0000516_abnormal_urinary_system0.92437998
108MP0005367_renal/urinary_system_phenotyp0.92437998
109MP0003693_abnormal_embryo_hatching0.92408431
110MP0009053_abnormal_anal_canal0.92243325
111MP0002064_seizures0.90215318
112MP0000534_abnormal_ureter_morphology0.89193451
113MP0002111_abnormal_tail_morphology0.88502847
114MP0002882_abnormal_neuron_morphology0.87508831
115MP0001835_abnormal_antigen_presentation0.87418478
116MP0002877_abnormal_melanocyte_morpholog0.87298591
117MP0009250_abnormal_appendicular_skeleto0.86941840
118MP0003984_embryonic_growth_retardation0.86740670
119MP0000733_abnormal_muscle_development0.86469580
120MP0001697_abnormal_embryo_size0.86188322
121MP0003938_abnormal_ear_development0.85734021
122MP0002088_abnormal_embryonic_growth/wei0.84456816
123MP0002752_abnormal_somatic_nervous0.84247495
124MP0009780_abnormal_chondrocyte_physiolo0.84151439
125MP0009745_abnormal_behavioral_response0.83939369
126MP0003436_decreased_susceptibility_to0.83924246
127MP0008260_abnormal_autophagy0.83702670
128MP0008057_abnormal_DNA_replication0.83496196
129MP0001730_embryonic_growth_arrest0.83443198
130MP0000579_abnormal_nail_morphology0.83393284
131MP0004272_abnormal_basement_membrane0.83113636
132MP0000955_abnormal_spinal_cord0.82549210
133MP0002653_abnormal_ependyma_morphology0.82133214
134MP0000427_abnormal_hair_cycle0.81753718
135MP0003755_abnormal_palate_morphology0.79986500
136MP0003861_abnormal_nervous_system0.78965763
137MP0000647_abnormal_sebaceous_gland0.78560919
138MP0002735_abnormal_chemical_nociception0.78375759
139MP0001879_abnormal_lymphatic_vessel0.77479327
140MP0001529_abnormal_vocalization0.76972948
141MP0003634_abnormal_glial_cell0.75681364
142MP0000681_abnormal_thyroid_gland0.75409239
143MP0002734_abnormal_mechanical_nocicepti0.75373842
144MP0002081_perinatal_lethality0.75252493
145MP0001851_eye_inflammation0.74724562
146MP0002933_joint_inflammation0.74666971
147MP0002419_abnormal_innate_immunity0.73684493
148MP0002152_abnormal_brain_morphology0.73119126
149MP0002572_abnormal_emotion/affect_behav0.72119565
150MP0003935_abnormal_craniofacial_develop0.72013195
151MP0002733_abnormal_thermal_nociception0.71859678
152MP0002896_abnormal_bone_mineralization0.71343498
153MP0001533_abnormal_skeleton_physiology0.71054436
154MP0002998_abnormal_bone_remodeling0.70978358
155MP0002452_abnormal_antigen_presenting0.70816369
156MP0000538_abnormal_urinary_bladder0.70048456
157MP0004381_abnormal_hair_follicle0.70030627
158MP0005423_abnormal_somatic_nervous0.69934917
159MP0003950_abnormal_plasma_membrane0.69404214

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.72918557
2Exotropia (HP:0000577)3.45557380
3Inappropriate behavior (HP:0000719)3.38670607
4Disinhibition (HP:0000734)3.22703231
5Protruding tongue (HP:0010808)2.98292098
6Papilledema (HP:0001085)2.86603289
7Drooling (HP:0002307)2.72004172
8Excessive salivation (HP:0003781)2.72004172
9Hepatoblastoma (HP:0002884)2.71014076
10Termporal pattern (HP:0011008)2.68424571
11Insidious onset (HP:0003587)2.68424571
12Shoulder girdle muscle weakness (HP:0003547)2.62930439
13Abnormality of the labia minora (HP:0012880)2.58897553
14Medulloblastoma (HP:0002885)2.56380511
15Absent frontal sinuses (HP:0002688)2.56171123
16Abnormality of the nasal septum (HP:0000419)2.53862356
17Prostate neoplasm (HP:0100787)2.49857253
18Thyroid carcinoma (HP:0002890)2.48367817
19Widely spaced teeth (HP:0000687)2.41053145
20Absent speech (HP:0001344)2.38594971
21Abnormality of the hip-girdle musculature (HP:0001445)2.33606674
22Abnormality of the musculature of the pelvis (HP:0001469)2.33606674
23Akinesia (HP:0002304)2.33600398
24Heterochromia iridis (HP:0001100)2.33558666
25Macroorchidism (HP:0000053)2.31656113
26Abnormality of the frontal sinuses (HP:0002687)2.30794486
27Obstructive lung disease (HP:0006536)2.30336013
28Chronic obstructive pulmonary disease (HP:0006510)2.30336013
29Spinal cord compression (HP:0002176)2.28530741
30Colon cancer (HP:0003003)2.28307525
31Submucous cleft hard palate (HP:0000176)2.27614755
32Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.25890575
33Abnormality of the corticospinal tract (HP:0002492)2.24914734
34Broad-based gait (HP:0002136)2.24674559
35Abnormality of salivation (HP:0100755)2.15779041
36Thyroiditis (HP:0100646)2.13374888
37Aqueductal stenosis (HP:0002410)2.11936938
38Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.09189061
39Short tibia (HP:0005736)2.08174879
40Fair hair (HP:0002286)2.06022983
41Eczematoid dermatitis (HP:0000976)2.04531450
42Oligodactyly (hands) (HP:0001180)2.04345353
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.03721516
44Amyotrophic lateral sclerosis (HP:0007354)2.02860941
45Blue irides (HP:0000635)2.00899916
46Increased nuchal translucency (HP:0010880)2.00661352
47Agitation (HP:0000713)2.00322344
48Abnormality of the lower motor neuron (HP:0002366)1.99682443
49Aplasia/Hypoplasia of the sternum (HP:0006714)1.97237618
50Large earlobe (HP:0009748)1.96019708
51Pelvic girdle muscle weakness (HP:0003749)1.95752732
52Generalized hypopigmentation of hair (HP:0011358)1.94378150
53Glioma (HP:0009733)1.94160093
54Urinary urgency (HP:0000012)1.91967495
55Thick nail (HP:0001805)1.91058946
56Lissencephaly (HP:0001339)1.90119040
57Aplasia cutis congenita (HP:0001057)1.89426660
58Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.88778233
59Morphological abnormality of the middle ear (HP:0008609)1.88212256
60Persistence of primary teeth (HP:0006335)1.88148432
61Impaired vibration sensation in the lower limbs (HP:0002166)1.87887447
62Recurrent abscess formation (HP:0002722)1.87506394
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87478770
64Degeneration of the lateral corticospinal tracts (HP:0002314)1.87478770
65Arterial tortuosity (HP:0005116)1.87472647
66Subacute progressive viral hepatitis (HP:0006572)1.87077822
67Split foot (HP:0001839)1.85923570
68Gait imbalance (HP:0002141)1.83627081
69Genital tract atresia (HP:0001827)1.83459155
70Pheochromocytoma (HP:0002666)1.81894010
71Progressive inability to walk (HP:0002505)1.81490347
72Micropenis (HP:0000054)1.80730832
73Abnormal lung lobation (HP:0002101)1.79921373
74Febrile seizures (HP:0002373)1.79524855
75Vertebral arch anomaly (HP:0008438)1.78971601
76Thickened helices (HP:0000391)1.78945827
77Mediastinal lymphadenopathy (HP:0100721)1.78830160
78Abnormality of chromosome stability (HP:0003220)1.78436492
79Tented upper lip vermilion (HP:0010804)1.77528770
80Congenital primary aphakia (HP:0007707)1.77356550
81Neoplasm of the adrenal cortex (HP:0100641)1.76241116
82Vaginal atresia (HP:0000148)1.75961952
83Abnormality of the antihelix (HP:0009738)1.75691201
84Supranuclear gaze palsy (HP:0000605)1.75655997
85Intellectual disability, moderate (HP:0002342)1.75310499
86Apathy (HP:0000741)1.74905368
87Limb-girdle muscle weakness (HP:0003325)1.73916566
88T lymphocytopenia (HP:0005403)1.73480813
89Volvulus (HP:0002580)1.73044169
90Vascular tortuosity (HP:0004948)1.72418338
91Focal motor seizures (HP:0011153)1.70907664
92Papillary thyroid carcinoma (HP:0002895)1.70322959
93Supernumerary spleens (HP:0009799)1.69907068
94Amblyopia (HP:0000646)1.69046400
95Syringomyelia (HP:0003396)1.68422475
96Spinal cord lesions (HP:0100561)1.68422475
97Chin dimple (HP:0010751)1.67868297
98Acrocyanosis (HP:0001063)1.67798962
99Truncal ataxia (HP:0002078)1.67702964
100Midline defect of the nose (HP:0004122)1.67559953
101Septo-optic dysplasia (HP:0100842)1.67499289
102Broad foot (HP:0001769)1.67192729
103Intestinal atresia (HP:0011100)1.67171382
104Wrist flexion contracture (HP:0001239)1.66311187
105Hemivertebrae (HP:0002937)1.65423983
106Asymmetry of the thorax (HP:0001555)1.65363530
107Hypoplasia of the iris (HP:0007676)1.65023250
108Postnatal microcephaly (HP:0005484)1.64984187
109Abnormality of T cell number (HP:0011839)1.64896549
110Recurrent bacterial skin infections (HP:0005406)1.64709069
111Medial flaring of the eyebrow (HP:0010747)1.64339254
112Neoplasm of the oral cavity (HP:0100649)1.64295423
113Rimmed vacuoles (HP:0003805)1.63923285
114Postaxial hand polydactyly (HP:0001162)1.63460815
115Mutism (HP:0002300)1.62718295
116Omphalocele (HP:0001539)1.62121451
117Broad ribs (HP:0000885)1.61988584
118Ulnar claw (HP:0001178)1.61653300
119Cupped ear (HP:0000378)1.61029401
120Chronic hepatic failure (HP:0100626)1.60927635
121Chromosomal breakage induced by crosslinking agents (HP:0003221)1.60802582
122Bifid tongue (HP:0010297)1.60583725
123Abnormality of the astrocytes (HP:0100707)1.60318853
124Astrocytoma (HP:0009592)1.60318853
125Hypoplastic pelvis (HP:0008839)1.60124704
126Transitional cell carcinoma of the bladder (HP:0006740)1.60008318
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.59994420
128Hypoplasia of the brainstem (HP:0002365)1.59994420
129Retinal dysplasia (HP:0007973)1.59854252
130Leiomyosarcoma (HP:0100243)1.59509630
131Uterine leiomyosarcoma (HP:0002891)1.59509630
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.59101780
133Diminished motivation (HP:0000745)1.58906765
134Limb-girdle muscle atrophy (HP:0003797)1.58123803
135Progressive sensorineural hearing impairment (HP:0000408)1.57791521
136Cutaneous syndactyly (HP:0012725)1.57752937
137Nephrogenic diabetes insipidus (HP:0009806)1.57217345
138Nephroblastoma (Wilms tumor) (HP:0002667)1.56429278
139Missing ribs (HP:0000921)1.55789425
140Chromsome breakage (HP:0040012)1.55535405
141Neuroendocrine neoplasm (HP:0100634)1.55535183
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.55519446
143Increased density of long bones (HP:0006392)1.54893925
144Dilatation of the ascending aorta (HP:0005111)1.54529889
145Oligodactyly (HP:0012165)1.54452305
146Facial hemangioma (HP:0000329)1.54190117
147Scrotal hypoplasia (HP:0000046)1.54013273
148Meckel diverticulum (HP:0002245)1.54008848
149Pachygyria (HP:0001302)1.53395013
150Renal hypoplasia (HP:0000089)1.53051335
151Labial hypoplasia (HP:0000066)1.52726371
152Preaxial foot polydactyly (HP:0001841)1.52317611
153Malignant gastrointestinal tract tumors (HP:0006749)1.52246938
154Gastrointestinal carcinoma (HP:0002672)1.52246938
155Cutaneous finger syndactyly (HP:0010554)1.51984087
156Increased neuronal autofluorescent lipopigment (HP:0002074)1.51636127
157Specific learning disability (HP:0001328)1.51150819
158Focal seizures (HP:0007359)1.50565153
159Abnormal auditory evoked potentials (HP:0006958)1.50499776
160Hematochezia (HP:0002573)1.50459267
161Progressive cerebellar ataxia (HP:0002073)1.49996434
162Embryonal renal neoplasm (HP:0011794)1.49660909
163Abnormality of the right ventricle (HP:0001707)1.48767202
164Infantile muscular hypotonia (HP:0008947)1.48586568
165Heterotopia (HP:0002282)1.48263162
166Myelomeningocele (HP:0002475)1.47611121
167Short 4th metacarpal (HP:0010044)1.47586208
168Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.47586208
169Narrow forehead (HP:0000341)1.47460881
170Hypoplastic labia majora (HP:0000059)1.46962025
171Cerebellar dysplasia (HP:0007033)1.46855490
172Optic nerve hypoplasia (HP:0000609)1.46400679
173Flat occiput (HP:0005469)1.46325634
174Cranial hyperostosis (HP:0004437)1.45497601
175Overgrowth (HP:0001548)1.45367896
176Lower limb amyotrophy (HP:0007210)1.45357949
177Open mouth (HP:0000194)1.44796873
178Abnormality of the parathyroid morphology (HP:0011766)1.44307911
179Bladder carcinoma (HP:0002862)1.44184718
180Bladder neoplasm (HP:0009725)1.44184718
181Action tremor (HP:0002345)1.43947021
182Abnormality of macrophages (HP:0004311)1.43133506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.72518707
2MARK13.55169468
3ERBB33.02714929
4BCR2.49452984
5TRIM282.41907096
6CASK2.40932742
7FRK2.27479526
8FGFR22.21184085
9WEE12.18055232
10RIPK42.16986436
11NUAK12.15748928
12MKNK11.93504689
13BMPR1B1.84750287
14TTK1.82528731
15TXK1.71713930
16FGR1.70581130
17DYRK21.70413336
18MAPK131.69899896
19MKNK21.68617673
20NEK11.62461709
21TSSK61.59586749
22SIK31.53525659
23CDC71.52703432
24KSR11.52037754
25MAP3K141.51655783
26PLK31.47918671
27TAF11.46410295
28STK38L1.46320097
29IRAK41.46268372
30CSNK1A1L1.45460935
31FGFR31.43075514
32SIK21.40395541
33PLK41.40222482
34NTRK31.38608321
35EPHA31.32011896
36LATS11.31606816
37TIE11.27491672
38CSNK1G21.22668440
39CAMKK21.20543644
40EPHA41.18707170
41LATS21.16970835
42YES11.16506201
43BUB11.16130371
44RPS6KA41.15064018
45SCYL21.14425934
46CSNK1G31.11917510
47UHMK11.11789130
48ITK1.09463356
49HIPK21.09454728
50CCNB11.08254993
51CSNK1G11.06523992
52ACVR1B1.05877468
53PLK11.00303180
54MAP3K40.98546623
55PKN10.98361421
56BMPR20.98231426
57PLK20.95366667
58NEK20.95141563
59MAP3K100.94957205
60LIMK10.94929761
61TLK10.94740058
62DYRK1A0.94244964
63MAP2K70.93154137
64ERBB40.92483408
65PNCK0.87449514
66EIF2AK30.86802809
67CLK10.86073738
68CDK50.85658414
69NEK90.84794957
70SRPK10.82728987
71CDK60.81301090
72CAMK1G0.80622850
73CDK180.80164963
74NTRK20.80041713
75PAK60.78118621
76PRKCQ0.77812525
77PRKCE0.76815699
78EPHB20.76072489
79CDK90.75345048
80TNIK0.75166678
81MINK10.74864504
82STK390.74554417
83SGK10.74150806
84PDGFRB0.73714473
85JAK30.73670513
86ZAK0.73213505
87CAMK2B0.71395457
88HCK0.71359943
89FES0.70977231
90PBK0.70875228
91CDK150.70527464
92RET0.69604860
93INSRR0.69585147
94PAK30.69236329
95MAP3K20.68349399
96MAP4K20.67277312
97MAP2K40.65853173
98MET0.64986291
99CDK11A0.64951151
100TEC0.64417220
101ATM0.63969878
102BRSK20.63776994
103TRPM70.62695326
104MAPKAPK50.61963822
105CHEK20.61874007
106STK30.59208797
107LCK0.59125633
108DYRK30.58930528
109INSR0.58586427
110CSK0.58024066
111DYRK1B0.57991046
112IRAK20.57142114
113EPHB10.55318885
114AURKB0.55227090
115RPS6KA50.54275422
116MELK0.53660250
117MAP3K120.53288255
118VRK10.52923198
119BRD40.52504019
120ATR0.52184783
121EGFR0.51958706
122RIPK10.49225734
123CDK140.49015688
124TGFBR10.48895218
125FYN0.48293424
126PDGFRA0.48217032
127BRSK10.47904088
128PAK20.47745656
129PRKCG0.47686281
130EIF2AK20.47472360
131IRAK10.47155405
132EIF2AK10.46696292
133CSNK1E0.46516609
134FGFR10.45469703
135CDK30.45275018
136WNK30.44209749
137NTRK10.42859701
138SGK4940.42837109
139SGK2230.42837109
140CHEK10.42728971
141FER0.42641482
142MAPK150.42367407
143MAP3K90.41013688
144CSNK1D0.37330968

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.63128400
2Non-homologous end-joining_Homo sapiens_hsa034502.52685719
3Cell cycle_Homo sapiens_hsa041102.26964055
4Protein export_Homo sapiens_hsa030602.13912669
5Fanconi anemia pathway_Homo sapiens_hsa034601.97583575
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94403480
7Mismatch repair_Homo sapiens_hsa034301.93404030
8Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.89710916
9Hippo signaling pathway_Homo sapiens_hsa043901.89439259
10Basal transcription factors_Homo sapiens_hsa030221.74743349
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71951950
12RNA transport_Homo sapiens_hsa030131.68733273
13Oocyte meiosis_Homo sapiens_hsa041141.67074210
14Basal cell carcinoma_Homo sapiens_hsa052171.63711550
15mRNA surveillance pathway_Homo sapiens_hsa030151.62096952
16Hedgehog signaling pathway_Homo sapiens_hsa043401.55818290
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51408769
18TGF-beta signaling pathway_Homo sapiens_hsa043501.50001486
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45383263
20Axon guidance_Homo sapiens_hsa043601.44879250
21Spliceosome_Homo sapiens_hsa030401.42961791
22Selenocompound metabolism_Homo sapiens_hsa004501.42015053
23Nucleotide excision repair_Homo sapiens_hsa034201.32361030
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31466615
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28061734
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23503647
27T cell receptor signaling pathway_Homo sapiens_hsa046601.23043594
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22285320
29Long-term depression_Homo sapiens_hsa047301.19023387
30DNA replication_Homo sapiens_hsa030301.16991023
31RNA degradation_Homo sapiens_hsa030181.15061538
32p53 signaling pathway_Homo sapiens_hsa041151.14200655
33Systemic lupus erythematosus_Homo sapiens_hsa053221.13811512
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13303025
35Nicotine addiction_Homo sapiens_hsa050331.12335589
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12226818
37Base excision repair_Homo sapiens_hsa034101.11542185
38Renal cell carcinoma_Homo sapiens_hsa052111.11149130
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10687307
40Long-term potentiation_Homo sapiens_hsa047201.10534427
41Phagosome_Homo sapiens_hsa041451.09361480
42Alcoholism_Homo sapiens_hsa050341.07855562
43Propanoate metabolism_Homo sapiens_hsa006401.07418532
44Homologous recombination_Homo sapiens_hsa034401.05970416
45Dopaminergic synapse_Homo sapiens_hsa047281.05898879
46Serotonergic synapse_Homo sapiens_hsa047261.05087340
47Osteoclast differentiation_Homo sapiens_hsa043801.04532895
48Glutamatergic synapse_Homo sapiens_hsa047241.03814395
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03645174
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03361601
51Circadian rhythm_Homo sapiens_hsa047101.02916178
52MicroRNAs in cancer_Homo sapiens_hsa052061.02086098
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01222118
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00931140
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.00835495
56Sphingolipid signaling pathway_Homo sapiens_hsa040711.00144229
57Graft-versus-host disease_Homo sapiens_hsa053320.99670915
58Cholinergic synapse_Homo sapiens_hsa047250.99465863
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98557559
60Chemokine signaling pathway_Homo sapiens_hsa040620.97830088
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97469280
62Allograft rejection_Homo sapiens_hsa053300.96874339
63Autoimmune thyroid disease_Homo sapiens_hsa053200.96204664
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96018342
65ErbB signaling pathway_Homo sapiens_hsa040120.95833024
66Glioma_Homo sapiens_hsa052140.95813438
67Colorectal cancer_Homo sapiens_hsa052100.95743881
68Salmonella infection_Homo sapiens_hsa051320.95012465
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94840182
70Pancreatic cancer_Homo sapiens_hsa052120.94624992
71Dorso-ventral axis formation_Homo sapiens_hsa043200.94600790
72Morphine addiction_Homo sapiens_hsa050320.94464696
73Leishmaniasis_Homo sapiens_hsa051400.94349195
74Shigellosis_Homo sapiens_hsa051310.94220469
75Renin secretion_Homo sapiens_hsa049240.93815405
76B cell receptor signaling pathway_Homo sapiens_hsa046620.93643079
77Chronic myeloid leukemia_Homo sapiens_hsa052200.93363311
78Type I diabetes mellitus_Homo sapiens_hsa049400.90896658
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88821731
80Viral myocarditis_Homo sapiens_hsa054160.88216541
81Rheumatoid arthritis_Homo sapiens_hsa053230.87899023
82Circadian entrainment_Homo sapiens_hsa047130.87239705
83Tuberculosis_Homo sapiens_hsa051520.86765823
84Platelet activation_Homo sapiens_hsa046110.86255691
85Cocaine addiction_Homo sapiens_hsa050300.85925897
86Tight junction_Homo sapiens_hsa045300.85875071
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84785965
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84220600
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84008377
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83872930
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83426268
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83278496
93TNF signaling pathway_Homo sapiens_hsa046680.83171603
94Prostate cancer_Homo sapiens_hsa052150.83026759
95Hepatitis B_Homo sapiens_hsa051610.81392742
96Measles_Homo sapiens_hsa051620.80147803
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79272915
98Choline metabolism in cancer_Homo sapiens_hsa052310.78814131
99Amphetamine addiction_Homo sapiens_hsa050310.78560350
100Focal adhesion_Homo sapiens_hsa045100.78208494
101Oxytocin signaling pathway_Homo sapiens_hsa049210.78115176
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77082608
103Toxoplasmosis_Homo sapiens_hsa051450.76963744
104Gap junction_Homo sapiens_hsa045400.76852894
105Endocytosis_Homo sapiens_hsa041440.76765774
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.76682804
107VEGF signaling pathway_Homo sapiens_hsa043700.76664846
108Sphingolipid metabolism_Homo sapiens_hsa006000.76522859
109Wnt signaling pathway_Homo sapiens_hsa043100.75454585
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75195041
111GnRH signaling pathway_Homo sapiens_hsa049120.74710816
112MAPK signaling pathway_Homo sapiens_hsa040100.74453504
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73824067
114Pertussis_Homo sapiens_hsa051330.73457047
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72992511
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.72540312
117Thyroid cancer_Homo sapiens_hsa052160.72412764
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72347375
119Phototransduction_Homo sapiens_hsa047440.72328965
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.72202422
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71946420
122Small cell lung cancer_Homo sapiens_hsa052220.71821919
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71435969
124Viral carcinogenesis_Homo sapiens_hsa052030.70859605
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69878806
126Ras signaling pathway_Homo sapiens_hsa040140.68141696
127Folate biosynthesis_Homo sapiens_hsa007900.68024694
128Estrogen signaling pathway_Homo sapiens_hsa049150.67870418
129Melanogenesis_Homo sapiens_hsa049160.67815831
130Adherens junction_Homo sapiens_hsa045200.67183244
131Type II diabetes mellitus_Homo sapiens_hsa049300.66778778
132Prolactin signaling pathway_Homo sapiens_hsa049170.66359501
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.66281559
134Proteoglycans in cancer_Homo sapiens_hsa052050.65970439
135Rap1 signaling pathway_Homo sapiens_hsa040150.65585560
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65235309
137Melanoma_Homo sapiens_hsa052180.65231207
138ECM-receptor interaction_Homo sapiens_hsa045120.64840939
139Pathways in cancer_Homo sapiens_hsa052000.64531101
140Malaria_Homo sapiens_hsa051440.64312154
141Hematopoietic cell lineage_Homo sapiens_hsa046400.64049194
142Endometrial cancer_Homo sapiens_hsa052130.63717583
143GABAergic synapse_Homo sapiens_hsa047270.63593053
144Butanoate metabolism_Homo sapiens_hsa006500.63415179
145N-Glycan biosynthesis_Homo sapiens_hsa005100.62809393
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62041486
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59542634
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57203862
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57148394
1502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56263553
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55820177
152Lysine degradation_Homo sapiens_hsa003100.55126006
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54805942
154Biosynthesis of amino acids_Homo sapiens_hsa012300.54258072
155Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51949278
156Cysteine and methionine metabolism_Homo sapiens_hsa002700.51178092
157Taste transduction_Homo sapiens_hsa047420.50287964
158Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50279924
159Fatty acid elongation_Homo sapiens_hsa000620.49665609
160Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48865505
161Regulation of autophagy_Homo sapiens_hsa041400.47955361
162Pyruvate metabolism_Homo sapiens_hsa006200.47127880
163Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44741306
164Dilated cardiomyopathy_Homo sapiens_hsa054140.44414915
165Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42859911
166Fatty acid metabolism_Homo sapiens_hsa012120.42618124
167Vitamin B6 metabolism_Homo sapiens_hsa007500.42384894
168AMPK signaling pathway_Homo sapiens_hsa041520.42015963

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