EXOC5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H4-K12 acetylation (GO:0043983)5.87259679
2neurofilament cytoskeleton organization (GO:0060052)5.26126266
3behavioral response to nicotine (GO:0035095)5.05552245
4organelle disassembly (GO:1903008)4.91822038
5ribonucleoprotein complex disassembly (GO:0032988)4.88706311
6platelet dense granule organization (GO:0060155)4.59753200
7response to pheromone (GO:0019236)4.51954515
8phosphorelay signal transduction system (GO:0000160)4.48307429
9piRNA metabolic process (GO:0034587)4.37822859
10regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.20870020
11cellular response to ATP (GO:0071318)4.13800781
12neuronal action potential (GO:0019228)4.11009429
13negative regulation of sodium ion transport (GO:0010766)4.10030587
14phenylpropanoid metabolic process (GO:0009698)4.06272233
15positive regulation of growth hormone secretion (GO:0060124)4.06235153
16locomotory exploration behavior (GO:0035641)4.05250549
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.95422897
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.95422897
19positive regulation of fatty acid transport (GO:2000193)3.83913680
20chaperone-mediated protein transport (GO:0072321)3.78410439
21DNA damage response, detection of DNA damage (GO:0042769)3.73051246
22positive regulation of icosanoid secretion (GO:0032305)3.68214681
23negative regulation of membrane potential (GO:0045837)3.67717067
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.56056769
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.54561181
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50417467
27positive regulation of prostaglandin secretion (GO:0032308)3.49558519
28limb development (GO:0060173)3.44470782
29appendage development (GO:0048736)3.44470782
30positive regulation of glycoprotein biosynthetic process (GO:0010560)3.34446656
31growth hormone secretion (GO:0030252)3.28433680
32regulation of non-canonical Wnt signaling pathway (GO:2000050)3.24421301
33ganglion development (GO:0061548)3.21930018
34cilium or flagellum-dependent cell motility (GO:0001539)3.19616518
35L-ascorbic acid metabolic process (GO:0019852)3.18256080
36protein localization to synapse (GO:0035418)3.14851611
37water-soluble vitamin biosynthetic process (GO:0042364)3.13484720
38neuron cell-cell adhesion (GO:0007158)3.11753573
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10490974
40positive regulation of synapse assembly (GO:0051965)3.09480762
41short-term memory (GO:0007614)3.08917124
42opioid receptor signaling pathway (GO:0038003)3.05375549
43synaptic transmission, cholinergic (GO:0007271)3.03784865
44regulation of meiosis I (GO:0060631)3.03283201
45axonemal dynein complex assembly (GO:0070286)3.01675556
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99808196
47glycerophospholipid catabolic process (GO:0046475)2.98545658
48regulation of growth hormone secretion (GO:0060123)2.95871224
49regulation of prostaglandin secretion (GO:0032306)2.93861679
50DNA deamination (GO:0045006)2.90115379
51positive regulation of organic acid transport (GO:0032892)2.87198479
52transmission of nerve impulse (GO:0019226)2.87094111
53L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84975949
54regulation of protein glycosylation (GO:0060049)2.84841599
55energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80895164
56ATP synthesis coupled proton transport (GO:0015986)2.80895164
57positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.79954424
58primary amino compound metabolic process (GO:1901160)2.79863636
59regulation of type B pancreatic cell apoptotic process (GO:2000674)2.79824951
60GPI anchor metabolic process (GO:0006505)2.79671125
61positive regulation of glycoprotein metabolic process (GO:1903020)2.79338279
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79064713
63glutamate receptor signaling pathway (GO:0007215)2.78883643
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76258723
65exploration behavior (GO:0035640)2.73035750
66detection of mechanical stimulus involved in sensory perception (GO:0050974)2.66702689
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.66154224
68NADH dehydrogenase complex assembly (GO:0010257)2.66154224
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66154224
70regulation of mitochondrial translation (GO:0070129)2.65616245
71vocalization behavior (GO:0071625)2.64716972
72regulation of uterine smooth muscle contraction (GO:0070472)2.63370425
73cellular ketone body metabolic process (GO:0046950)2.59710089
74regulation of icosanoid secretion (GO:0032303)2.59688037
75anterograde axon cargo transport (GO:0008089)2.59519978
76endoderm formation (GO:0001706)2.58830292
77protein complex biogenesis (GO:0070271)2.58592041
78inner mitochondrial membrane organization (GO:0007007)2.57318496
79serotonin metabolic process (GO:0042428)2.54155606
80motile cilium assembly (GO:0044458)2.52369813
81DNA methylation involved in gamete generation (GO:0043046)2.51243833
82serotonin receptor signaling pathway (GO:0007210)2.49739689
83negative regulation of calcium ion transport into cytosol (GO:0010523)2.48418593
84peripheral nervous system development (GO:0007422)2.46942867
85flavonoid metabolic process (GO:0009812)2.46907431
86plasma membrane fusion (GO:0045026)2.46458052
87negative regulation by host of viral transcription (GO:0043922)2.46184994
88synaptic transmission, glutamatergic (GO:0035249)2.46171772
89pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.45812309
90UMP metabolic process (GO:0046049)2.45812309
91pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.45812309
92UMP biosynthetic process (GO:0006222)2.45812309
93secretory granule organization (GO:0033363)2.45416185
94spinal cord motor neuron differentiation (GO:0021522)2.43732538
95peptidyl-histidine modification (GO:0018202)2.43615255
96presynaptic membrane assembly (GO:0097105)2.41439729
97relaxation of cardiac muscle (GO:0055119)2.40895765
98calcium ion-dependent exocytosis (GO:0017156)2.40523962
99magnesium ion transport (GO:0015693)2.40299115
100negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.39851878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.46250188
2EZH2_22144423_ChIP-Seq_EOC_Human4.34732772
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.46943085
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37357175
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87697876
6VDR_22108803_ChIP-Seq_LS180_Human2.85368358
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77681441
8IGF1R_20145208_ChIP-Seq_DFB_Human2.76952907
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76734123
10EWS_26573619_Chip-Seq_HEK293_Human2.23259280
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17666066
12ZNF274_21170338_ChIP-Seq_K562_Hela2.16222423
13TAF15_26573619_Chip-Seq_HEK293_Human2.15577712
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06650260
15FUS_26573619_Chip-Seq_HEK293_Human2.03760948
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91533382
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91216590
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84919720
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82608771
20ER_23166858_ChIP-Seq_MCF-7_Human1.81319420
21P300_19829295_ChIP-Seq_ESCs_Human1.77691557
22SMAD3_21741376_ChIP-Seq_EPCs_Human1.75646095
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74651916
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74617430
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.73687569
26SMAD4_21799915_ChIP-Seq_A2780_Human1.71168774
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70164749
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.69435434
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62325169
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60913341
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.53797171
32RNF2_27304074_Chip-Seq_NSC_Mouse1.53711507
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51088609
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50807662
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50045410
36AR_21572438_ChIP-Seq_LNCaP_Human1.47838652
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.43647432
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42902995
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.41805700
40RUNX2_22187159_ChIP-Seq_PCA_Human1.40881093
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40719299
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40719299
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40036264
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.36695869
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.35666321
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35660524
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35247514
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35179976
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31828662
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31294657
51IRF1_19129219_ChIP-ChIP_H3396_Human1.31286018
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30529174
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29375748
54REST_21632747_ChIP-Seq_MESCs_Mouse1.26814042
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26770301
56TP53_22573176_ChIP-Seq_HFKS_Human1.25733837
57TCF4_22108803_ChIP-Seq_LS180_Human1.23651706
58BCAT_22108803_ChIP-Seq_LS180_Human1.21540721
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19879972
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16602676
61MYC_18940864_ChIP-ChIP_HL60_Human1.16044532
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15363687
63AR_25329375_ChIP-Seq_VCAP_Human1.15317463
64LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14800064
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13014351
66SOX2_19829295_ChIP-Seq_ESCs_Human1.12769228
67NANOG_19829295_ChIP-Seq_ESCs_Human1.12769228
68TCF4_23295773_ChIP-Seq_U87_Human1.12418198
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.12395682
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11985453
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10543569
72ELK1_19687146_ChIP-ChIP_HELA_Human1.08008707
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.07857853
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07569129
75STAT3_23295773_ChIP-Seq_U87_Human1.07241913
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.05879911
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05591680
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04332049
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.04242829
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.02968722
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.02823794
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02521938
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02487110
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01862547
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01738732
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.00764598
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.00336176
88TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00262687
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99363740
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99219675
91RNF2_27304074_Chip-Seq_ESCs_Mouse0.98760161
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98117155
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.98117155
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97452394
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95865444
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95107069
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95042987
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94143230
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93993585
100REST_18959480_ChIP-ChIP_MESCs_Mouse0.93163249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.41649454
2MP0002102_abnormal_ear_morphology3.04740799
3MP0004742_abnormal_vestibular_system3.04089715
4MP0003880_abnormal_central_pattern3.03562067
5MP0002653_abnormal_ependyma_morphology2.98823570
6MP0000537_abnormal_urethra_morphology2.96604448
7MP0009046_muscle_twitch2.82944120
8MP0010386_abnormal_urinary_bladder2.74566397
9MP0001485_abnormal_pinna_reflex2.70079762
10MP0002735_abnormal_chemical_nociception2.61984428
11MP0004147_increased_porphyrin_level2.52367400
12MP0001486_abnormal_startle_reflex2.23175348
13MP0003195_calcinosis2.16758514
14MP0002837_dystrophic_cardiac_calcinosis1.99862339
15MP0009745_abnormal_behavioral_response1.98317487
16MP0001968_abnormal_touch/_nociception1.94326526
17MP0000778_abnormal_nervous_system1.92812843
18MP0004142_abnormal_muscle_tone1.92797462
19MP0005423_abnormal_somatic_nervous1.89450344
20MP0002277_abnormal_respiratory_mucosa1.87499112
21MP0003122_maternal_imprinting1.77957086
22MP0003635_abnormal_synaptic_transmissio1.69824066
23MP0003878_abnormal_ear_physiology1.69265320
24MP0005377_hearing/vestibular/ear_phenot1.69265320
25MP0002067_abnormal_sensory_capabilities1.68700240
26MP0002272_abnormal_nervous_system1.64902206
27MP0005551_abnormal_eye_electrophysiolog1.60605691
28MP0005645_abnormal_hypothalamus_physiol1.59807203
29MP0002064_seizures1.57686246
30MP0000749_muscle_degeneration1.57348574
31MP0005075_abnormal_melanosome_morpholog1.54411323
32MP0003119_abnormal_digestive_system1.51235885
33MP0002163_abnormal_gland_morphology1.49645895
34MP0005248_abnormal_Harderian_gland1.40303082
35MP0002572_abnormal_emotion/affect_behav1.39349425
36MP0001293_anophthalmia1.39191149
37MP0008775_abnormal_heart_ventricle1.37890693
38MP0006292_abnormal_olfactory_placode1.35852099
39MP0001440_abnormal_grooming_behavior1.32077665
40MP0001529_abnormal_vocalization1.31447949
41MP0002638_abnormal_pupillary_reflex1.30007257
42MP0002557_abnormal_social/conspecific_i1.29003586
43MP0002938_white_spotting1.27227766
44MP0003011_delayed_dark_adaptation1.25511911
45MP0005171_absent_coat_pigmentation1.23914081
46MP0004381_abnormal_hair_follicle1.23459935
47MP0001970_abnormal_pain_threshold1.22753426
48MP0003121_genomic_imprinting1.21825757
49MP0004270_analgesia1.21255896
50MP0002736_abnormal_nociception_after1.19695245
51MP0008872_abnormal_physiological_respon1.18216720
52MP0002184_abnormal_innervation1.16262798
53MP0000955_abnormal_spinal_cord1.15101211
54MP0002734_abnormal_mechanical_nocicepti1.15066074
55MP0003646_muscle_fatigue1.12467928
56MP0005084_abnormal_gallbladder_morpholo1.12076919
57MP0002733_abnormal_thermal_nociception1.11259172
58MP0000750_abnormal_muscle_regeneration1.10886894
59MP0003950_abnormal_plasma_membrane1.10004527
60MP0005379_endocrine/exocrine_gland_phen1.09944841
61MP0005670_abnormal_white_adipose1.08762396
62MP0002752_abnormal_somatic_nervous1.07274361
63MP0002751_abnormal_autonomic_nervous1.05692879
64MP0001879_abnormal_lymphatic_vessel1.05207067
65MP0002063_abnormal_learning/memory/cond1.03210909
66MP0001986_abnormal_taste_sensitivity1.02360721
67MP0004859_abnormal_synaptic_plasticity1.02241959
68MP0000372_irregular_coat_pigmentation1.01263686
69MP0001502_abnormal_circadian_rhythm1.00364808
70MP0003941_abnormal_skin_development0.99626158
71MP0004885_abnormal_endolymph0.98443085
72MP0001542_abnormal_bone_strength0.97332294
73MP0004924_abnormal_behavior0.96897388
74MP0005386_behavior/neurological_phenoty0.96897388
75MP0000631_abnormal_neuroendocrine_gland0.96200466
76MP0005195_abnormal_posterior_eye0.96009371
77MP0006072_abnormal_retinal_apoptosis0.92054449
78MP0003567_abnormal_fetal_cardiomyocyte0.87872053
79MP0003937_abnormal_limbs/digits/tail_de0.87416992
80MP0000026_abnormal_inner_ear0.87306541
81MP0002229_neurodegeneration0.87051593
82MP0004134_abnormal_chest_morphology0.85343547
83MP0001963_abnormal_hearing_physiology0.82210558
84MP0003633_abnormal_nervous_system0.81949359
85MP0008789_abnormal_olfactory_epithelium0.81690550
86MP0000230_abnormal_systemic_arterial0.81615448
87MP0010030_abnormal_orbit_morphology0.80997659
88MP0001324_abnormal_eye_pigmentation0.80263386
89MP0003938_abnormal_ear_development0.80194310
90MP0001286_abnormal_eye_development0.79711763
91MP0000538_abnormal_urinary_bladder0.79258591
92MP0002882_abnormal_neuron_morphology0.77750634
93MP0002090_abnormal_vision0.76456038
94MP0002066_abnormal_motor_capabilities/c0.75530527
95MP0003137_abnormal_impulse_conducting0.75391597
96MP0004133_heterotaxia0.75242980
97MP0003631_nervous_system_phenotype0.74934292
98MP0002095_abnormal_skin_pigmentation0.73287300
99MP0000049_abnormal_middle_ear0.72224704
100MP0004145_abnormal_muscle_electrophysio0.72037034

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.63320851
2Type II lissencephaly (HP:0007260)3.78996941
3Medial flaring of the eyebrow (HP:0010747)3.60140074
4Ulnar claw (HP:0001178)3.54397303
5Nephrogenic diabetes insipidus (HP:0009806)3.52392533
6Pancreatic cysts (HP:0001737)3.47923863
7Chronic bronchitis (HP:0004469)3.45591872
8Inability to walk (HP:0002540)3.44111223
9Optic nerve hypoplasia (HP:0000609)3.32653117
10Gait imbalance (HP:0002141)3.26594706
11Hyperglycinemia (HP:0002154)3.09162425
12Congenital primary aphakia (HP:0007707)3.05481985
13Anophthalmia (HP:0000528)3.03727602
14Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.02809827
15Septo-optic dysplasia (HP:0100842)3.01326249
16Congenital, generalized hypertrichosis (HP:0004540)2.97853032
17Vaginal atresia (HP:0000148)2.83961372
18Pancreatic fibrosis (HP:0100732)2.82029508
19Genital tract atresia (HP:0001827)2.80291474
20Lissencephaly (HP:0001339)2.79601119
21Focal motor seizures (HP:0011153)2.75496458
22Arthropathy (HP:0003040)2.71443700
23Adrenal hypoplasia (HP:0000835)2.67511357
24True hermaphroditism (HP:0010459)2.59171907
25Retinal dysplasia (HP:0007973)2.56174978
26Slender build (HP:0001533)2.56097189
27Prominent supraorbital ridges (HP:0000336)2.51883355
28Hypoplasia of the brainstem (HP:0002365)2.50215496
29Aplasia/Hypoplasia of the brainstem (HP:0007362)2.50215496
30Midline defect of the nose (HP:0004122)2.49422793
31Hyperglycinuria (HP:0003108)2.48191723
32Poor coordination (HP:0002370)2.47671736
33Hypogonadotrophic hypogonadism (HP:0000044)2.44759696
34Esophageal atresia (HP:0002032)2.42120413
35Anterior segment dysgenesis (HP:0007700)2.40617141
36Abnormal respiratory motile cilium physiology (HP:0012261)2.40100897
37Large for gestational age (HP:0001520)2.39713195
38Meningocele (HP:0002435)2.34805617
39Molar tooth sign on MRI (HP:0002419)2.32774199
40Abnormality of midbrain morphology (HP:0002418)2.32774199
41Progressive inability to walk (HP:0002505)2.31924109
42Amblyopia (HP:0000646)2.27137137
43Sclerocornea (HP:0000647)2.26769158
44Abnormal number of erythroid precursors (HP:0012131)2.23479049
45Congenital hepatic fibrosis (HP:0002612)2.23113088
46Conjugated hyperbilirubinemia (HP:0002908)2.21063636
47Confusion (HP:0001289)2.20988011
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20607608
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20607608
50Rhinitis (HP:0012384)2.20350012
51Anencephaly (HP:0002323)2.20199925
52Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.17846488
53Nephronophthisis (HP:0000090)2.17788274
54Neoplasm of the adrenal cortex (HP:0100641)2.15704153
55Abnormality of the axillary hair (HP:0100134)2.15193632
56Abnormality of secondary sexual hair (HP:0009888)2.15193632
57Abnormality of alanine metabolism (HP:0010916)2.12432879
58Hyperalaninemia (HP:0003348)2.12432879
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12432879
60Abnormality of cells of the erythroid lineage (HP:0012130)2.10096786
61Broad metatarsal (HP:0001783)2.08475293
62Maternal diabetes (HP:0009800)2.06377446
63Mesomelia (HP:0003027)2.06112695
64Postaxial foot polydactyly (HP:0001830)2.05933360
653-Methylglutaconic aciduria (HP:0003535)2.04727128
66Hepatoblastoma (HP:0002884)2.03953886
67Cerebral hypomyelination (HP:0006808)2.03493092
68Cerebellar dysplasia (HP:0007033)2.02724582
69Dandy-Walker malformation (HP:0001305)1.98920467
70Facial cleft (HP:0002006)1.96901673
71Abnormality of the ileum (HP:0001549)1.94933630
72Renal salt wasting (HP:0000127)1.93979544
73Type I transferrin isoform profile (HP:0003642)1.93071999
74Pachygyria (HP:0001302)1.92922078
75Absent septum pellucidum (HP:0001331)1.92418256
76Increased corneal curvature (HP:0100692)1.87990564
77Keratoconus (HP:0000563)1.87990564
78Gastrointestinal atresia (HP:0002589)1.87824002
79Focal seizures (HP:0007359)1.87600627
80Self-mutilation (HP:0000742)1.85211337
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85178767
82Abnormal protein N-linked glycosylation (HP:0012347)1.85178767
83Abnormal protein glycosylation (HP:0012346)1.85178767
84Abnormal glycosylation (HP:0012345)1.85178767
85Aplasia/Hypoplasia of the sternum (HP:0006714)1.81535874
86Increased number of teeth (HP:0011069)1.81390937
87Epidermoid cyst (HP:0200040)1.80507481
88Preaxial hand polydactyly (HP:0001177)1.79821446
89Male pseudohermaphroditism (HP:0000037)1.79728107
90Acute necrotizing encephalopathy (HP:0006965)1.79609718
91Small hand (HP:0200055)1.79547908
92Abnormality of the renal medulla (HP:0100957)1.79209637
93Bilateral microphthalmos (HP:0007633)1.78621878
94Meckel diverticulum (HP:0002245)1.77973233
95Abnormality of the septum pellucidum (HP:0007375)1.77727422
96CNS hypomyelination (HP:0003429)1.76541668
97Congenital sensorineural hearing impairment (HP:0008527)1.76520633
98Acute encephalopathy (HP:0006846)1.76320724
99Hypoplasia of the pons (HP:0012110)1.76183326
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75607656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.53395407
2FES3.57490542
3TIE13.20000291
4INSRR2.95718710
5NUAK12.62418203
6WNK32.49509242
7PNCK2.40877500
8FER2.26942135
9MAPK132.19394802
10BUB12.14174826
11PINK12.12056788
12CDK191.96832755
13BMPR1B1.93163309
14STK241.83715662
15MST41.80871872
16GRK11.75949839
17ADRBK21.75460446
18STK31.72951346
19MAPKAPK31.69538898
20ADRBK11.53686207
21CAMKK21.51540033
22OXSR11.48617130
23BCR1.42796194
24NEK21.31179859
25VRK21.25991278
26LATS11.24228396
27DYRK21.22997377
28IRAK11.21579995
29MARK11.19847989
30SCYL21.19822755
31PRKCE1.16610659
32CHEK21.16172142
33TNIK1.08670258
34NEK91.08384275
35MUSK1.06483851
36NEK11.03829535
37TAOK31.02356533
38MAP3K111.02153898
39CSNK1G21.00777547
40PRKD30.99845369
41FRK0.97833129
42MINK10.97830570
43KDR0.95156926
44ZAK0.94947937
45TRIM280.94043684
46PLK20.93896507
47TXK0.93558079
48MAP4K20.92646359
49EPHA40.92403387
50UHMK10.91580925
51PRKCG0.90899950
52TAOK10.90451572
53CSNK1G30.87060337
54NME20.85694723
55CDC70.83765851
56NTRK10.82289828
57TAF10.82063374
58CSNK1G10.81760749
59PHKG20.81055750
60PHKG10.81055750
61MAP2K40.80903814
62PLK30.80209924
63MYLK0.79178029
64EPHA30.78869071
65ACVR1B0.78505699
66TLK10.77962567
67MAP3K60.77527542
68PLK10.76389842
69MAP2K70.69697699
70OBSCN0.68562104
71TGFBR10.67826914
72VRK10.67725622
73CSNK1A10.64928676
74AURKA0.64564810
75CHUK0.64240812
76FGFR10.63705425
77CSNK1A1L0.62809721
78ERBB30.61787989
79EPHB20.59425896
80TEC0.58050566
81PTK2B0.57720418
82TYRO30.56795917
83PRKCQ0.53941139
84GRK70.53900426
85SRPK10.53233469
86PBK0.52930364
87PRKACA0.49312206
88CAMK10.47057593
89DAPK30.46678682
90DAPK10.42651324
91CAMK2A0.42439643
92PRKACB0.37413022
93WEE10.36970607
94PRKCA0.35976603
95PLK40.35446039
96CAMK1G0.33942716
97ILK0.29053941
98CCNB10.28104760
99CDK11A0.27043580
100CSNK1E0.26823956

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.81585696
2Oxidative phosphorylation_Homo sapiens_hsa001903.24283056
3Ribosome_Homo sapiens_hsa030102.72859588
4Parkinsons disease_Homo sapiens_hsa050122.56172604
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24524675
6Selenocompound metabolism_Homo sapiens_hsa004502.21882550
7Alzheimers disease_Homo sapiens_hsa050102.08717376
8Cardiac muscle contraction_Homo sapiens_hsa042602.07462758
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04571803
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00353060
11RNA polymerase_Homo sapiens_hsa030201.93041386
12Huntingtons disease_Homo sapiens_hsa050161.92076871
13Taste transduction_Homo sapiens_hsa047421.81184774
14Glutamatergic synapse_Homo sapiens_hsa047241.72783388
15Circadian entrainment_Homo sapiens_hsa047131.66446342
16Protein export_Homo sapiens_hsa030601.66059457
17Olfactory transduction_Homo sapiens_hsa047401.64259497
18Sulfur relay system_Homo sapiens_hsa041221.64074787
19Linoleic acid metabolism_Homo sapiens_hsa005911.60318717
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55671302
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54409889
22GABAergic synapse_Homo sapiens_hsa047271.54064095
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52917152
24Fanconi anemia pathway_Homo sapiens_hsa034601.48995986
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45525969
26Amphetamine addiction_Homo sapiens_hsa050311.40669538
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35154553
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33111020
29Asthma_Homo sapiens_hsa053101.32130830
30Proteasome_Homo sapiens_hsa030501.31244290
31Phototransduction_Homo sapiens_hsa047441.30373776
32Gastric acid secretion_Homo sapiens_hsa049711.29066942
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26288244
34Butanoate metabolism_Homo sapiens_hsa006501.25341387
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22655026
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19051945
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16567410
38Nitrogen metabolism_Homo sapiens_hsa009101.15792193
39Pyruvate metabolism_Homo sapiens_hsa006201.15705592
40Calcium signaling pathway_Homo sapiens_hsa040201.14990406
41Homologous recombination_Homo sapiens_hsa034401.09251106
42Serotonergic synapse_Homo sapiens_hsa047261.04584669
43Dopaminergic synapse_Homo sapiens_hsa047281.04403846
44Oxytocin signaling pathway_Homo sapiens_hsa049211.04121767
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01542965
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01053603
47Mismatch repair_Homo sapiens_hsa034301.00942716
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99830701
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97461767
50Long-term depression_Homo sapiens_hsa047300.96045560
51Basal transcription factors_Homo sapiens_hsa030220.95831568
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.92795775
53Morphine addiction_Homo sapiens_hsa050320.92758669
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89790284
55Basal cell carcinoma_Homo sapiens_hsa052170.88931827
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88530756
57Ether lipid metabolism_Homo sapiens_hsa005650.88040281
58Arachidonic acid metabolism_Homo sapiens_hsa005900.86858987
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.84233901
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83922373
61RNA transport_Homo sapiens_hsa030130.83249239
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82644868
63Tryptophan metabolism_Homo sapiens_hsa003800.82274710
64Cholinergic synapse_Homo sapiens_hsa047250.80670218
65Chemical carcinogenesis_Homo sapiens_hsa052040.78876581
66Fatty acid elongation_Homo sapiens_hsa000620.72471473
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70463498
68Rheumatoid arthritis_Homo sapiens_hsa053230.69513258
69Synaptic vesicle cycle_Homo sapiens_hsa047210.67672054
70Starch and sucrose metabolism_Homo sapiens_hsa005000.63924477
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.60474919
72Dorso-ventral axis formation_Homo sapiens_hsa043200.60089235
73Autoimmune thyroid disease_Homo sapiens_hsa053200.58988730
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58658669
75Insulin secretion_Homo sapiens_hsa049110.58224745
76Caffeine metabolism_Homo sapiens_hsa002320.57923485
77Metabolic pathways_Homo sapiens_hsa011000.57850483
78Propanoate metabolism_Homo sapiens_hsa006400.54106943
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52182723
80Retinol metabolism_Homo sapiens_hsa008300.51678468
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50846978
82Wnt signaling pathway_Homo sapiens_hsa043100.50548203
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50109628
84Salivary secretion_Homo sapiens_hsa049700.48454389
85Arginine and proline metabolism_Homo sapiens_hsa003300.47436646
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.47262676
87Steroid biosynthesis_Homo sapiens_hsa001000.47193328
88Graft-versus-host disease_Homo sapiens_hsa053320.46927108
89Hedgehog signaling pathway_Homo sapiens_hsa043400.46468067
90Type I diabetes mellitus_Homo sapiens_hsa049400.45506308
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.45483866
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.45403571
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45320671
94Purine metabolism_Homo sapiens_hsa002300.44821578
95Hippo signaling pathway_Homo sapiens_hsa043900.43531070
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42960382
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42654520
98Pyrimidine metabolism_Homo sapiens_hsa002400.41777049
99One carbon pool by folate_Homo sapiens_hsa006700.40298012
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40001387

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