EXOC6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a part of the evolutionarily conserved exocyst, a multimeric protein complex necessary for exocytosis, which in turn, is crucial for cell growth, polarity and migration. Disruption of this gene may be associated with phenotypes exhibiting multiple symptoms including intellectual disability and developmental delay (DD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.17265921
2central nervous system myelination (GO:0022010)6.17265921
3myelination (GO:0042552)4.33142681
4ensheathment of neurons (GO:0007272)4.29951520
5axon ensheathment (GO:0008366)4.29951520
6neuron cell-cell adhesion (GO:0007158)4.08481351
7presynaptic membrane assembly (GO:0097105)3.97620293
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90529264
9negative regulation of neurotransmitter secretion (GO:0046929)3.89195643
10presynaptic membrane organization (GO:0097090)3.88179703
11long-chain fatty acid biosynthetic process (GO:0042759)3.87840103
12hemidesmosome assembly (GO:0031581)3.86516039
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84857294
14cell communication by electrical coupling (GO:0010644)3.82814270
15desmosome organization (GO:0002934)3.80945910
16cell communication involved in cardiac conduction (GO:0086065)3.78772036
17transmission of nerve impulse (GO:0019226)3.77429727
18negative regulation of neurotransmitter transport (GO:0051589)3.70260618
19synaptic vesicle maturation (GO:0016188)3.69044468
20bundle of His cell to Purkinje myocyte communication (GO:0086069)3.65296879
21L-amino acid import (GO:0043092)3.51326195
22neuron recognition (GO:0008038)3.43749039
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42960083
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.38379902
25apical protein localization (GO:0045176)3.37163898
26dendritic spine morphogenesis (GO:0060997)3.36212867
27regulation of cardioblast differentiation (GO:0051890)3.35990600
28peptidyl-tyrosine autophosphorylation (GO:0038083)3.34604911
29neuronal action potential propagation (GO:0019227)3.27075263
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25941183
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.23795336
32dendrite morphogenesis (GO:0048813)3.23368473
33axonal fasciculation (GO:0007413)3.22941529
34nerve growth factor signaling pathway (GO:0038180)3.22614925
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.21514266
36establishment of mitochondrion localization (GO:0051654)3.19183395
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.18426873
38sodium ion export (GO:0071436)3.18343260
39neuronal ion channel clustering (GO:0045161)3.17179487
40cardiac myofibril assembly (GO:0055003)3.14140480
41glutamate secretion (GO:0014047)3.14015260
42locomotory exploration behavior (GO:0035641)3.12590128
43synaptic vesicle exocytosis (GO:0016079)3.12387950
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.11984786
45asymmetric protein localization (GO:0008105)3.10782637
46fatty acid elongation (GO:0030497)3.08264126
47protein localization to synapse (GO:0035418)3.07824877
48vocalization behavior (GO:0071625)3.07476452
49regulation of synaptic vesicle exocytosis (GO:2000300)3.06939053
50adult walking behavior (GO:0007628)3.05880977
51positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.03970023
52regulation of actin filament-based movement (GO:1903115)3.03936914
53regulation of cardiac muscle cell contraction (GO:0086004)3.01675840
54oligodendrocyte differentiation (GO:0048709)3.01599357
55gamma-aminobutyric acid signaling pathway (GO:0007214)2.99892368
56synaptic transmission, glutamatergic (GO:0035249)2.96875370
57cerebral cortex radially oriented cell migration (GO:0021799)2.96636917
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96261189
59regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94812239
60glutamate receptor signaling pathway (GO:0007215)2.94498487
61paraxial mesoderm development (GO:0048339)2.93628474
62regulation of neuronal synaptic plasticity (GO:0048168)2.90149005
63negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.90055347
64cerebellar granule cell differentiation (GO:0021707)2.86160852
65regulation of dendritic spine morphogenesis (GO:0061001)2.83671628
66regulation of glutamate receptor signaling pathway (GO:1900449)2.81434857
67positive regulation of action potential (GO:0045760)2.81157169
68negative regulation of axonogenesis (GO:0050771)2.80340060
69ventricular cardiac muscle cell action potential (GO:0086005)2.78309829
70gap junction assembly (GO:0016264)2.78171024
71neuron-neuron synaptic transmission (GO:0007270)2.77780987
72cardiac muscle hypertrophy (GO:0003300)2.76307562
73regulation of long-term neuronal synaptic plasticity (GO:0048169)2.75063593
74negative regulation of protein localization to cell surface (GO:2000009)2.74618793
75central nervous system projection neuron axonogenesis (GO:0021952)2.73585736
76regulation of cell communication by electrical coupling (GO:0010649)2.69699214
77cellular potassium ion homeostasis (GO:0030007)2.69431713
78peripheral nervous system axon ensheathment (GO:0032292)2.68538091
79myelination in peripheral nervous system (GO:0022011)2.68538091
80auditory behavior (GO:0031223)2.66133620
81negative regulation of axon extension (GO:0030517)2.64830684
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64352534
83regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64319703
84regulation of dendritic spine development (GO:0060998)2.62551166
85sarcomere organization (GO:0045214)2.62478003
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62241316
87glycerophospholipid catabolic process (GO:0046475)2.62188190
88amino acid import (GO:0043090)2.62013025
89eye photoreceptor cell differentiation (GO:0001754)2.61926960
90photoreceptor cell differentiation (GO:0046530)2.61926960
91dendritic spine organization (GO:0097061)2.61748068
92dendrite development (GO:0016358)2.61649150
93striated muscle hypertrophy (GO:0014897)2.60385503
94synaptic vesicle endocytosis (GO:0048488)2.59870517
95positive regulation of dendritic spine development (GO:0060999)2.59754632
96negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59280961
97regulation of the force of heart contraction (GO:0002026)2.58278096
98postsynaptic membrane organization (GO:0001941)2.57128161
99myofibril assembly (GO:0030239)2.55984337
100organelle transport along microtubule (GO:0072384)2.55772328
101membrane assembly (GO:0071709)2.55640062
102positive regulation of membrane potential (GO:0045838)2.55505463
103astrocyte development (GO:0014002)2.54426295
104exploration behavior (GO:0035640)2.54405853
105cellular response to epinephrine stimulus (GO:0071872)2.52736472
106regulation of collateral sprouting (GO:0048670)2.51577978
107cell-substrate junction assembly (GO:0007044)2.51568854
108regulation of synaptic vesicle transport (GO:1902803)2.51427812
109myelin maintenance (GO:0043217)2.51360139
110layer formation in cerebral cortex (GO:0021819)2.50192581
111positive regulation of synapse assembly (GO:0051965)2.50137506
112cardiac muscle contraction (GO:0060048)2.50097111
113regulation of transforming growth factor beta2 production (GO:0032909)2.50057659
114regulation of postsynaptic membrane potential (GO:0060078)2.49969232
115negative regulation of vascular permeability (GO:0043116)2.48398292
116gamma-aminobutyric acid transport (GO:0015812)2.47445013
117cardiac muscle hypertrophy in response to stress (GO:0014898)2.46589140
118muscle hypertrophy in response to stress (GO:0003299)2.46589140
119cardiac muscle adaptation (GO:0014887)2.46589140
120long-term memory (GO:0007616)2.46487443
121establishment of nucleus localization (GO:0040023)2.46228941
122vesicle transport along microtubule (GO:0047496)2.43880909
123regulation of voltage-gated calcium channel activity (GO:1901385)2.43417830
124cell migration in hindbrain (GO:0021535)2.43177749
125limb bud formation (GO:0060174)2.41607017
126cardiac muscle cell action potential (GO:0086001)2.41513750
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41009230
128central nervous system neuron axonogenesis (GO:0021955)2.40791727
129regulation of synaptic plasticity (GO:0048167)2.40438456
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40176887
131regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.39588697
132regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39267309
133cellular response to catecholamine stimulus (GO:0071870)2.38946835
134cellular response to monoamine stimulus (GO:0071868)2.38946835
135cytoskeletal anchoring at plasma membrane (GO:0007016)2.38314999
136membrane hyperpolarization (GO:0060081)2.37151319
137adult locomotory behavior (GO:0008344)2.36867743
138glycine transport (GO:0015816)2.36297990
139negative regulation of keratinocyte proliferation (GO:0010839)2.35960067
140cardiac muscle cell development (GO:0055013)2.35248734
141cellular sodium ion homeostasis (GO:0006883)2.33672412
142cardiac muscle cell action potential involved in contraction (GO:0086002)2.31559267
143embryonic foregut morphogenesis (GO:0048617)2.31429309
144cardiac cell development (GO:0055006)2.30999280
145positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.30616908
146regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.29555740
147positive regulation of cardiac muscle tissue growth (GO:0055023)2.27063899
148adult heart development (GO:0007512)2.26991732
149positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.26817325
150actomyosin structure organization (GO:0031032)2.25753964
151detection of calcium ion (GO:0005513)2.25380560
152retina vasculature morphogenesis in camera-type eye (GO:0061299)2.23921980
153hippo signaling (GO:0035329)2.23293690
154negative regulation of potassium ion transmembrane transport (GO:1901380)2.22188779
155epithelial cell-cell adhesion (GO:0090136)2.20561186
156positive regulation of heart growth (GO:0060421)2.19585562
157neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.19493269
158myoblast fusion (GO:0007520)2.19351129
159cardiac conduction (GO:0061337)2.17757858
160adherens junction assembly (GO:0034333)2.17226745
161morphogenesis of an epithelial sheet (GO:0002011)2.16133550
162regulation of axon extension involved in axon guidance (GO:0048841)2.15791437
163negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.15240171
164embryonic retina morphogenesis in camera-type eye (GO:0060059)2.14932044
165positive regulation of cardiac muscle cell proliferation (GO:0060045)2.14439413
166relaxation of cardiac muscle (GO:0055119)2.13212276
167regulation of cAMP-dependent protein kinase activity (GO:2000479)2.10470932
168axon extension (GO:0048675)2.10050689
169lymphangiogenesis (GO:0001946)2.07767568
170regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.07472312
171axon extension involved in axon guidance (GO:0048846)2.07018764
172neuron projection extension involved in neuron projection guidance (GO:1902284)2.07018764
173regulation of heart rate by cardiac conduction (GO:0086091)2.06386116
174muscle hypertrophy (GO:0014896)2.06267636
175developmental cell growth (GO:0048588)2.06166868
176neuromuscular junction development (GO:0007528)2.05830274
177positive regulation of cardiac muscle tissue development (GO:0055025)2.04323980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97036685
2GBX2_23144817_ChIP-Seq_PC3_Human3.57963542
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63168879
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60763385
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57745755
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.53238452
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32462882
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32462882
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.27836455
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25137385
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.18920585
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18452678
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17825987
14DROSHA_22980978_ChIP-Seq_HELA_Human2.14748390
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14283444
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13519180
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07466777
18RNF2_27304074_Chip-Seq_ESCs_Mouse1.97585375
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.91420845
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91306295
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90225654
22* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82143556
23* REST_21632747_ChIP-Seq_MESCs_Mouse1.75681360
24* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75671989
25AR_21572438_ChIP-Seq_LNCaP_Human1.72512061
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71368148
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70303669
28TAF15_26573619_Chip-Seq_HEK293_Human1.65914588
29CTNNB1_20460455_ChIP-Seq_HCT116_Human1.65825680
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65689292
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.64287049
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.63834218
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62387998
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62311041
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59279730
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57022487
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56146775
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55377828
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54045131
40SMAD4_21799915_ChIP-Seq_A2780_Human1.53641064
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.52331000
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.51636898
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49417160
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.48552571
45* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45289884
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44592143
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.43921509
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.43523603
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42471870
50P300_19829295_ChIP-Seq_ESCs_Human1.40522322
51* STAT3_23295773_ChIP-Seq_U87_Human1.39245199
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38724064
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36914494
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36511714
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.36117350
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35806577
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31844637
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30455748
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.28277679
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28271498
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28246419
62AHR_22903824_ChIP-Seq_MCF-7_Human1.28242153
63CJUN_26792858_Chip-Seq_BT549_Human1.28056736
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28040692
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26806430
66FUS_26573619_Chip-Seq_HEK293_Human1.25893597
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.25814878
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24839077
69RNF2_27304074_Chip-Seq_NSC_Mouse1.24048166
70VDR_22108803_ChIP-Seq_LS180_Human1.23012499
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21852085
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19863215
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.19026711
74ER_23166858_ChIP-Seq_MCF-7_Human1.18739957
75* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18360624
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.17913976
77* TCF4_23295773_ChIP-Seq_U87_Human1.17097591
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16952329
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16776982
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.16085721
81TP53_16413492_ChIP-PET_HCT116_Human1.15896176
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15746129
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15217734
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14146021
85* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11188045
86* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10841189
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10415016
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.09965882
89IGF1R_20145208_ChIP-Seq_DFB_Human1.09564717
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09474520
91* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08909513
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08481753
93SOX9_26525672_Chip-Seq_HEART_Mouse1.07675376
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07567555
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06953497
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06630219
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06169165
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05933409
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05679945
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05518681
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.05041354
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.04942068
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04773614
104AR_19668381_ChIP-Seq_PC3_Human1.04061228
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03979850
106ZNF274_21170338_ChIP-Seq_K562_Hela1.03141063
107AR_25329375_ChIP-Seq_VCAP_Human1.03076217
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.01680018
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01604480
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00885739
111TP53_18474530_ChIP-ChIP_U2OS_Human1.00860798
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00674316
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00414060
114* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00314270
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.99671984
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.99671984
117* RUNX2_22187159_ChIP-Seq_PCA_Human0.98695624
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97604225
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96893230
120BRD4_25478319_ChIP-Seq_HGPS_Human0.96771637
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95083898
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.94337472
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.93998466
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93502490
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93502490
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93420433
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93420433
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.92854253
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92700678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.78592599
2MP0003880_abnormal_central_pattern4.49342095
3MP0004270_analgesia3.78615116
4MP0003635_abnormal_synaptic_transmissio2.96290726
5MP0000920_abnormal_myelination2.91530656
6MP0003941_abnormal_skin_development2.67522201
7MP0002064_seizures2.63989892
8MP0000579_abnormal_nail_morphology2.56158938
9MP0009745_abnormal_behavioral_response2.52711195
10MP0002272_abnormal_nervous_system2.52619196
11MP0001486_abnormal_startle_reflex2.51805996
12MP0004084_abnormal_cardiac_muscle2.45047510
13MP0000778_abnormal_nervous_system2.44351166
14MP0000751_myopathy2.42437312
15MP0005275_abnormal_skin_tensile2.37888457
16MP0009046_muscle_twitch2.35206305
17MP0005171_absent_coat_pigmentation2.34974461
18MP0002063_abnormal_learning/memory/cond2.29668505
19MP0004885_abnormal_endolymph2.29087952
20MP0002734_abnormal_mechanical_nocicepti2.22804415
21MP0010368_abnormal_lymphatic_system2.21692420
22MP0004272_abnormal_basement_membrane2.18278898
23MP0002572_abnormal_emotion/affect_behav2.08370122
24MP0005423_abnormal_somatic_nervous1.98801716
25MP0004742_abnormal_vestibular_system1.85757527
26MP0008438_abnormal_cutaneous_collagen1.84445842
27MP0003705_abnormal_hypodermis_morpholog1.82292062
28MP0004215_abnormal_myocardial_fiber1.79465807
29MP0003690_abnormal_glial_cell1.79180215
30MP0005409_darkened_coat_color1.76697792
31MP0000955_abnormal_spinal_cord1.74560575
32MP0003566_abnormal_cell_adhesion1.74111135
33MP0001968_abnormal_touch/_nociception1.72543281
34MP0003634_abnormal_glial_cell1.71168855
35MP0001440_abnormal_grooming_behavior1.70474523
36MP0008569_lethality_at_weaning1.65753835
37MP0002067_abnormal_sensory_capabilities1.63971637
38MP0006138_congestive_heart_failure1.62708983
39MP0002733_abnormal_thermal_nociception1.60865350
40MP0004036_abnormal_muscle_relaxation1.59777296
41MP0003329_amyloid_beta_deposits1.56422998
42MP0002882_abnormal_neuron_morphology1.55363297
43MP0009780_abnormal_chondrocyte_physiolo1.52184499
44MP0001970_abnormal_pain_threshold1.51553233
45MP0001905_abnormal_dopamine_level1.51275654
46MP0001485_abnormal_pinna_reflex1.50103812
47MP0002735_abnormal_chemical_nociception1.49731973
48MP0001501_abnormal_sleep_pattern1.49001861
49MP0005645_abnormal_hypothalamus_physiol1.48764314
50MP0001529_abnormal_vocalization1.48058000
51MP0003632_abnormal_nervous_system1.46966481
52MP0002184_abnormal_innervation1.43903674
53MP0004924_abnormal_behavior1.40694961
54MP0005386_behavior/neurological_phenoty1.40694961
55MP0001188_hyperpigmentation1.39169872
56MP0003950_abnormal_plasma_membrane1.38752950
57MP0004142_abnormal_muscle_tone1.38379459
58MP0002557_abnormal_social/conspecific_i1.34729878
59MP0002229_neurodegeneration1.34252425
60MP0003136_yellow_coat_color1.34160648
61MP0005623_abnormal_meninges_morphology1.31949702
62MP0010352_gastrointestinal_tract_polyps1.31729508
63MP0003631_nervous_system_phenotype1.31359258
64MP0002066_abnormal_motor_capabilities/c1.29605256
65MP0003122_maternal_imprinting1.28563437
66MP0003633_abnormal_nervous_system1.28406543
67MP0004811_abnormal_neuron_physiology1.27430736
68MP0004145_abnormal_muscle_electrophysio1.25931622
69MP0005646_abnormal_pituitary_gland1.23345991
70MP0001299_abnormal_eye_distance/1.23009559
71MP0009384_cardiac_valve_regurgitation1.22360506
72MP0002972_abnormal_cardiac_muscle1.21126457
73MP0000462_abnormal_digestive_system1.20880323
74MP0003787_abnormal_imprinting1.18863852
75MP0004858_abnormal_nervous_system1.18755289
76MP0002796_impaired_skin_barrier1.17876245
77MP0005503_abnormal_tendon_morphology1.17384938
78MP0001984_abnormal_olfaction1.17072662
79MP0002234_abnormal_pharynx_morphology1.15993418
80MP0002736_abnormal_nociception_after1.15854878
81MP0005620_abnormal_muscle_contractility1.15734426
82MP0004087_abnormal_muscle_fiber1.14753330
83MP0002152_abnormal_brain_morphology1.13981733
84MP0000749_muscle_degeneration1.13924060
85MP0010234_abnormal_vibrissa_follicle1.12587452
86MP0002822_catalepsy1.12357672
87MP0000537_abnormal_urethra_morphology1.12111199
88MP0003283_abnormal_digestive_organ1.12103483
89MP0001963_abnormal_hearing_physiology1.12055427
90MP0005257_abnormal_intraocular_pressure1.10596119
91MP0010678_abnormal_skin_adnexa1.09713829
92MP0005187_abnormal_penis_morphology1.09700401
93MP0005248_abnormal_Harderian_gland1.08454132
94MP0002752_abnormal_somatic_nervous1.07093957
95MP0000428_abnormal_craniofacial_morphol1.06731742
96MP0001502_abnormal_circadian_rhythm1.05483799
97MP0005551_abnormal_eye_electrophysiolog1.04675577
98MP0001958_emphysema1.04433058
99MP0010030_abnormal_orbit_morphology1.04194054
100MP0004484_altered_response_of1.03721099
101MP0010630_abnormal_cardiac_muscle1.03334066
102MP0000534_abnormal_ureter_morphology1.01889833
103MP0000383_abnormal_hair_follicle0.97227685
104MP0006276_abnormal_autonomic_nervous0.96733590
105MP0001177_atelectasis0.95233989
106MP0000467_abnormal_esophagus_morphology0.94100627
107MP0002233_abnormal_nose_morphology0.93991184
108MP0006072_abnormal_retinal_apoptosis0.93562948
109MP0008775_abnormal_heart_ventricle0.93308006
110MP0003137_abnormal_impulse_conducting0.93199917
111MP0003890_abnormal_embryonic-extraembry0.92509506
112MP0005330_cardiomyopathy0.91420588
113MP0004233_abnormal_muscle_weight0.91281215
114MP0001346_abnormal_lacrimal_gland0.90410986
115MP0000569_abnormal_digit_pigmentation0.90390358
116MP0005670_abnormal_white_adipose0.89878443
117MP0003935_abnormal_craniofacial_develop0.89113582
118MP0004134_abnormal_chest_morphology0.88221059
119MP0000631_abnormal_neuroendocrine_gland0.88092994
120MP0002108_abnormal_muscle_morphology0.87729486
121MP0001879_abnormal_lymphatic_vessel0.86997881
122MP0004133_heterotaxia0.86445555
123MP0000733_abnormal_muscle_development0.84827035
124MP0002697_abnormal_eye_size0.84399895
125MP0003861_abnormal_nervous_system0.80918549
126MP0003938_abnormal_ear_development0.80850345
127MP0003091_abnormal_cell_migration0.80504055
128MP0002269_muscular_atrophy0.79665733
129MP0000026_abnormal_inner_ear0.79252084
130MP0003279_aneurysm0.78785966
131MP0009053_abnormal_anal_canal0.78221938
132MP0004043_abnormal_pH_regulation0.77812022
133MP0000747_muscle_weakness0.77577141
134MP0002127_abnormal_cardiovascular_syste0.77123400
135MP0000762_abnormal_tongue_morphology0.76768152
136MP0000432_abnormal_head_morphology0.76633682
137MP0005385_cardiovascular_system_phenoty0.75983387
138MP0001544_abnormal_cardiovascular_syste0.75983387
139MP0002295_abnormal_pulmonary_circulatio0.75925530
140MP0005394_taste/olfaction_phenotype0.74891408
141MP0005499_abnormal_olfactory_system0.74891408
142MP0003942_abnormal_urinary_system0.73500274
143MP0002896_abnormal_bone_mineralization0.73468793
144MP0000759_abnormal_skeletal_muscle0.72728010
145MP0003119_abnormal_digestive_system0.71672966
146MP0005369_muscle_phenotype0.71556383
147MP0003937_abnormal_limbs/digits/tail_de0.69371622
148MP0000013_abnormal_adipose_tissue0.68840286
149MP0002751_abnormal_autonomic_nervous0.68718824
150MP0000566_synostosis0.68586095
151MP0001943_abnormal_respiration0.64906399
152MP0004085_abnormal_heartbeat0.63384377
153MP0005410_abnormal_fertilization0.63331016
154MP0005195_abnormal_posterior_eye0.63191485
155MP0002069_abnormal_eating/drinking_beha0.62496620
156MP0002177_abnormal_outer_ear0.61746770
157MP0003385_abnormal_body_wall0.61717998
158MP0003755_abnormal_palate_morphology0.61218532
159MP0002909_abnormal_adrenal_gland0.59256467
160MP0000003_abnormal_adipose_tissue0.58020673
161MP0009250_abnormal_appendicular_skeleto0.57939408

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.60832466
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.38693668
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.38693668
4Myokymia (HP:0002411)4.18790920
5Right ventricular cardiomyopathy (HP:0011663)4.02298776
6Neurofibrillary tangles (HP:0002185)3.90800428
7Abnormality of the corticospinal tract (HP:0002492)3.75823969
8Sensory axonal neuropathy (HP:0003390)3.61551073
9Supranuclear gaze palsy (HP:0000605)3.60228370
10Focal seizures (HP:0007359)3.44548907
11Atonic seizures (HP:0010819)3.30564050
12Epileptic encephalopathy (HP:0200134)3.17834672
13Bundle branch block (HP:0011710)3.17141088
14Dysmetria (HP:0001310)3.11273971
15Peripheral hypomyelination (HP:0007182)3.08649836
16Cerebral inclusion bodies (HP:0100314)3.08060225
17Alacrima (HP:0000522)3.04615788
18Action tremor (HP:0002345)3.04079223
19Sudden death (HP:0001699)3.03585724
20Spastic gait (HP:0002064)3.03308638
21Parakeratosis (HP:0001036)3.00010697
22Progressive cerebellar ataxia (HP:0002073)2.96494041
23Scanning speech (HP:0002168)2.89110828
24Intention tremor (HP:0002080)2.88291833
25Ankle clonus (HP:0011448)2.85316260
26Atrophic scars (HP:0001075)2.79634353
27Gaze-evoked nystagmus (HP:0000640)2.78904158
28Ventricular tachycardia (HP:0004756)2.75499751
29Hyporeflexia of lower limbs (HP:0002600)2.72549283
30Anteriorly placed anus (HP:0001545)2.70004831
31Onion bulb formation (HP:0003383)2.68393711
32Akinesia (HP:0002304)2.63675128
33Visual hallucinations (HP:0002367)2.63047030
34Thickened helices (HP:0000391)2.60386670
35Febrile seizures (HP:0002373)2.59280901
36Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.52637751
37Broad-based gait (HP:0002136)2.51988239
38Atrial fibrillation (HP:0005110)2.51916142
39Arterial tortuosity (HP:0005116)2.45623123
40Vascular tortuosity (HP:0004948)2.38976790
41Syncope (HP:0001279)2.38086072
42Aplasia involving bones of the upper limbs (HP:0009823)2.34814669
43Aplasia of the phalanges of the hand (HP:0009802)2.34814669
44Aplasia involving bones of the extremities (HP:0009825)2.34814669
45Dialeptic seizures (HP:0011146)2.32793373
46Termporal pattern (HP:0011008)2.32652500
47Insidious onset (HP:0003587)2.32652500
48Megalencephaly (HP:0001355)2.32166699
49Decreased lacrimation (HP:0000633)2.31291639
50Absent speech (HP:0001344)2.29927336
51Protrusio acetabuli (HP:0003179)2.26181520
52Shallow orbits (HP:0000586)2.25431379
53Lower limb muscle weakness (HP:0007340)2.24712507
54Papillary thyroid carcinoma (HP:0002895)2.20803407
55Primary atrial arrhythmia (HP:0001692)2.19660042
56Absence seizures (HP:0002121)2.19209638
57Drooling (HP:0002307)2.17802095
58Excessive salivation (HP:0003781)2.17802095
59Truncal ataxia (HP:0002078)2.17625876
60Abnormal hair whorl (HP:0010721)2.17108243
61Dysdiadochokinesis (HP:0002075)2.17043730
62Absent eyelashes (HP:0000561)2.16688101
63Cutaneous finger syndactyly (HP:0010554)2.14386696
64Urinary bladder sphincter dysfunction (HP:0002839)2.14369307
65Widely spaced teeth (HP:0000687)2.14065161
66Generalized tonic-clonic seizures (HP:0002069)2.12620708
67Overgrowth (HP:0001548)2.11912310
68Hyperventilation (HP:0002883)2.09618985
69Cutaneous syndactyly (HP:0012725)2.04906296
70Supraventricular tachycardia (HP:0004755)2.03047233
71Retinal dysplasia (HP:0007973)2.02262628
72Hemiparesis (HP:0001269)2.02014283
73Dysmetric saccades (HP:0000641)2.01702461
74Abnormality of the calf musculature (HP:0001430)2.01648717
75Supraventricular arrhythmia (HP:0005115)2.01331729
76Hypoplastic labia majora (HP:0000059)1.95573166
77Genetic anticipation (HP:0003743)1.94943581
78Synostosis involving the elbow (HP:0003938)1.93978341
79Humeroradial synostosis (HP:0003041)1.93978341
80Coronal craniosynostosis (HP:0004440)1.92901178
81Heart block (HP:0012722)1.92534673
82Abnormality of nail color (HP:0100643)1.91796039
83Broad metatarsal (HP:0001783)1.91476429
84Aortic aneurysm (HP:0004942)1.90649469
85Clumsiness (HP:0002312)1.90531422
86Abnormal atrioventricular conduction (HP:0005150)1.89020215
87Abnormality of the lower motor neuron (HP:0002366)1.88118721
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87990046
89Progressive inability to walk (HP:0002505)1.87436325
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86697588
91Cupped ear (HP:0000378)1.86191879
92Diplopia (HP:0000651)1.86187051
93Abnormality of binocular vision (HP:0011514)1.86187051
94Increased circulating renin level (HP:0000848)1.86174872
95Vertebral arch anomaly (HP:0008438)1.84021779
96Bronchomalacia (HP:0002780)1.82301755
97Aqueductal stenosis (HP:0002410)1.81434372
98Relative macrocephaly (HP:0004482)1.81031383
99Blue irides (HP:0000635)1.80866738
100Hepatoblastoma (HP:0002884)1.80825708
101Abnormality of the left ventricular outflow tract (HP:0011103)1.80627391
102Subaortic stenosis (HP:0001682)1.80627391
103Premature rupture of membranes (HP:0001788)1.80112159
104Bowel incontinence (HP:0002607)1.79565448
105Limited hip movement (HP:0008800)1.79420752
106Slow saccadic eye movements (HP:0000514)1.79220857
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78112870
108Atrioventricular block (HP:0001678)1.77816233
109Preaxial foot polydactyly (HP:0001841)1.77097503
110Generalized myoclonic seizures (HP:0002123)1.76811127
111Natal tooth (HP:0000695)1.76580577
112Abnormality of salivation (HP:0100755)1.76529322
113Metabolic alkalosis (HP:0200114)1.76280412
114Esophageal atresia (HP:0002032)1.75033996
115Buphthalmos (HP:0000557)1.73919524
116Difficulty running (HP:0009046)1.73400579
117Abnormality of the labia majora (HP:0012881)1.73355064
118Mutism (HP:0002300)1.73223699
119Neonatal short-limb short stature (HP:0008921)1.72718826
120Mildly elevated creatine phosphokinase (HP:0008180)1.72364812
121Gastroesophageal reflux (HP:0002020)1.70842533
122Lipoatrophy (HP:0100578)1.70392299
123Absent septum pellucidum (HP:0001331)1.70243611
124Fetal akinesia sequence (HP:0001989)1.69904309
125Lower limb amyotrophy (HP:0007210)1.69238993
126Bradycardia (HP:0001662)1.68599292
127Morphological abnormality of the inner ear (HP:0011390)1.68360115
128Decreased motor nerve conduction velocity (HP:0003431)1.68134718
129Advanced eruption of teeth (HP:0006288)1.67675361
130Turricephaly (HP:0000262)1.67396258
131Abnormal eating behavior (HP:0100738)1.65960776
132Urinary urgency (HP:0000012)1.64093804
133Ulnar claw (HP:0001178)1.63684119
134Mixed hearing impairment (HP:0000410)1.63509114
135Abnormality of the dental root (HP:0006486)1.63186170
136Taurodontia (HP:0000679)1.63186170
137Abnormality of permanent molar morphology (HP:0011071)1.63186170
138Alopecia of scalp (HP:0002293)1.62998821
139Ventricular arrhythmia (HP:0004308)1.62645940
140Pheochromocytoma (HP:0002666)1.62623823
141Onycholysis (HP:0001806)1.62285932
142Abnormality of molar (HP:0011077)1.62285306
143Abnormality of molar morphology (HP:0011070)1.62285306
144Wormian bones (HP:0002645)1.62124235
145Type 1 muscle fiber predominance (HP:0003803)1.61903082
146Impaired vibration sensation in the lower limbs (HP:0002166)1.61879119
147Partial agenesis of the corpus callosum (HP:0001338)1.61446649
148Abnormal large intestine physiology (HP:0012700)1.61352034
149Fragile nails (HP:0001808)1.61211966
150Split foot (HP:0001839)1.61023297
151Anxiety (HP:0000739)1.60542663
152Bell-shaped thorax (HP:0001591)1.60180127
153Macroorchidism (HP:0000053)1.60121326
154Hammertoe (HP:0001765)1.60009357
155Hypoplastic left heart (HP:0004383)1.59533639
156Skin pits (HP:0100276)1.59374900
157Intellectual disability, moderate (HP:0002342)1.59290336
158Limb dystonia (HP:0002451)1.58561152
159Long nose (HP:0003189)1.58395137
160Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.58386988
161Steppage gait (HP:0003376)1.57932021
162Infantile muscular hypotonia (HP:0008947)1.57441134
163Muscle fiber splitting (HP:0003555)1.57141889
164Milia (HP:0001056)1.57035333
165Periauricular skin pits (HP:0100277)1.56543360
166Preauricular pit (HP:0004467)1.56543360
167Plantar hyperkeratosis (HP:0007556)1.54241434
168Laryngomalacia (HP:0001601)1.53876702
169Pulmonic stenosis (HP:0001642)1.53822071
170Abnormality of the salivary glands (HP:0010286)1.53653042
171Aortic dissection (HP:0002647)1.52305639
172Complete atrioventricular canal defect (HP:0001674)1.49402873
173Labial hypoplasia (HP:0000066)1.47041172
174Hypoplasia of the iris (HP:0007676)1.46843215
175Wide anterior fontanel (HP:0000260)1.46637274
176Increased connective tissue (HP:0009025)1.45943650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.50420499
2OXSR13.18426768
3PRPF4B3.08066620
4EPHA42.97468033
5NTRK32.83484648
6TNIK2.64729235
7MARK12.43545968
8PDGFRA2.36410488
9LATS12.31969931
10LATS22.27958933
11CDK192.22968482
12CASK2.22837008
13MYLK2.00120153
14BCR1.99436157
15RIPK11.95862872
16TTN1.94986027
17STK241.89526267
18NEK61.87635224
19MAP3K91.84503028
20PAK61.83030838
21PKN11.82735516
22UHMK11.81858957
23ICK1.74591053
24MET1.72412073
25WNK11.72043568
26EPHB11.70738761
27FGFR21.64892206
28NTRK11.64694773
29STK38L1.60583579
30OBSCN1.57798039
31PNCK1.52622993
32PTK21.41250311
33CAMK2B1.39394871
34MAP3K41.32718680
35SGK2231.31335875
36SGK4941.31335875
37MAP3K131.30877366
38CDK51.29990340
39EPHB21.25196805
40FGR1.22680464
41NTRK21.21860717
42TYRO31.18248551
43MINK11.14752475
44CSNK1A1L1.14437296
45BMPR1B1.13294640
46MAPK151.09973757
47MAP2K71.09215753
48PAK31.09175012
49CAMK2D1.09092150
50NEK91.06104956
51PINK11.04260701
52MARK21.03763664
53PHKG21.02527776
54PHKG11.02527776
55WNK41.02161917
56CAMK1G1.01550776
57ROCK21.01182080
58CAMK2A0.99732352
59MST1R0.99145113
60CSNK1G20.99078027
61BRD40.94514864
62ERBB30.93460883
63PRKCE0.92533846
64MAP3K60.92037853
65LIMK10.91420376
66CSNK1G30.91095300
67DDR20.89500058
68PRKD30.89265357
69MAPK130.88984921
70PBK0.88729285
71FGFR10.87472622
72AKT30.87325589
73DAPK20.86147296
74EEF2K0.85651539
75CAMK40.85634648
76LMTK20.83627047
77CLK10.83208117
78ERBB40.82696230
79ROCK10.82153165
80GRK50.77011794
81CSNK1G10.76431681
82PLK20.76364924
83CDK140.75197560
84MAPKAPK50.75181596
85RET0.74596423
86CDK150.74143653
87CDK180.73341025
88KSR20.73050029
89CAMK10.72487477
90MAP3K20.71519374
91CAMK2G0.70927976
92CDC42BPA0.68995086
93PDPK10.66746468
94MST40.66038610
95INSRR0.65485044
96CDK11A0.65274222
97STK380.64652763
98STK110.64233722
99PIK3CA0.63067379
100SGK10.62455623
101PTK2B0.61666760
102PRKD10.60477858
103KSR10.60084305
104PRKCG0.59050625
105FYN0.58584966
106MTOR0.58069109
107MAP2K40.57723417
108PRKCQ0.57645845
109FES0.57447310
110DYRK20.57066279
111SGK20.56682828
112TRPM70.56419609
113PRKD20.55782380
114DYRK1A0.55198117
115FER0.54227716
116PAK20.53736316
117MAPK100.52816833
118HIPK20.52195386
119PRKG10.52156478
120PDGFRB0.51939300
121PRKCH0.51519003
122CAMKK10.51426120
123CDK120.49883815
124RPS6KA20.48369378
125CAMK1D0.48061277
126TIE10.47570802
127BMPR20.46948979
128BMX0.46220226
129PRKAA10.45616130
130EPHA30.45453105
131MAPK70.45384121
132DMPK0.45294246
133SGK30.44867083
134EPHA20.44713519
135TGFBR10.44330071
136STK30.42876093
137CSNK1D0.42220326
138MUSK0.42166754
139RPS6KA30.41914127
140ARAF0.41829008

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.59601064
2Glutamatergic synapse_Homo sapiens_hsa047242.22329224
3GABAergic synapse_Homo sapiens_hsa047272.18421856
4Axon guidance_Homo sapiens_hsa043602.11198636
5Morphine addiction_Homo sapiens_hsa050322.07986477
6Synaptic vesicle cycle_Homo sapiens_hsa047212.07247794
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07114518
8Circadian entrainment_Homo sapiens_hsa047132.02017166
9Adherens junction_Homo sapiens_hsa045201.83594763
10Olfactory transduction_Homo sapiens_hsa047401.82241333
11Long-term potentiation_Homo sapiens_hsa047201.81179003
12Serotonergic synapse_Homo sapiens_hsa047261.80050693
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73441175
14Amphetamine addiction_Homo sapiens_hsa050311.70429393
15Dopaminergic synapse_Homo sapiens_hsa047281.68672284
16Salivary secretion_Homo sapiens_hsa049701.68019562
17Long-term depression_Homo sapiens_hsa047301.61902030
18Taste transduction_Homo sapiens_hsa047421.60837273
19Cholinergic synapse_Homo sapiens_hsa047251.59506233
20Insulin secretion_Homo sapiens_hsa049111.52844304
21Cocaine addiction_Homo sapiens_hsa050301.50806054
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42930689
23Steroid biosynthesis_Homo sapiens_hsa001001.40615546
24Gastric acid secretion_Homo sapiens_hsa049711.40529553
25Ether lipid metabolism_Homo sapiens_hsa005651.35953296
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35203401
27Renin secretion_Homo sapiens_hsa049241.34552450
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33562569
29ErbB signaling pathway_Homo sapiens_hsa040121.29771646
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27145184
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24140061
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21111844
33Calcium signaling pathway_Homo sapiens_hsa040201.20184784
34Circadian rhythm_Homo sapiens_hsa047101.19783272
35Oxytocin signaling pathway_Homo sapiens_hsa049211.19091321
36Vibrio cholerae infection_Homo sapiens_hsa051101.18967802
37Dorso-ventral axis formation_Homo sapiens_hsa043201.18738809
38Collecting duct acid secretion_Homo sapiens_hsa049661.18530132
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16790075
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15596615
41cAMP signaling pathway_Homo sapiens_hsa040241.14934588
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14410351
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14345050
44Sphingolipid metabolism_Homo sapiens_hsa006001.13219653
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11959110
46Gap junction_Homo sapiens_hsa045401.11273915
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10422285
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09508982
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08520825
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06943259
51Ras signaling pathway_Homo sapiens_hsa040141.04685302
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04658219
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.04250391
54Type II diabetes mellitus_Homo sapiens_hsa049301.04104728
55Melanogenesis_Homo sapiens_hsa049161.02501887
56GnRH signaling pathway_Homo sapiens_hsa049121.02002938
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.01442432
58Tight junction_Homo sapiens_hsa045300.99741990
59Renal cell carcinoma_Homo sapiens_hsa052110.98386545
60Hedgehog signaling pathway_Homo sapiens_hsa043400.97479051
61Protein digestion and absorption_Homo sapiens_hsa049740.97111636
62Endometrial cancer_Homo sapiens_hsa052130.95655844
63MAPK signaling pathway_Homo sapiens_hsa040100.91721313
64Choline metabolism in cancer_Homo sapiens_hsa052310.90450422
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90120826
66TGF-beta signaling pathway_Homo sapiens_hsa043500.88800770
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.88732792
68Phototransduction_Homo sapiens_hsa047440.87613010
69Wnt signaling pathway_Homo sapiens_hsa043100.87532549
70Estrogen signaling pathway_Homo sapiens_hsa049150.86804897
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86108614
72Bile secretion_Homo sapiens_hsa049760.85663371
73Arginine biosynthesis_Homo sapiens_hsa002200.84628933
74AMPK signaling pathway_Homo sapiens_hsa041520.83685271
75Endocytosis_Homo sapiens_hsa041440.83099381
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81933696
77Pancreatic secretion_Homo sapiens_hsa049720.81210808
78Amoebiasis_Homo sapiens_hsa051460.81074542
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79645601
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79484632
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78973888
82MicroRNAs in cancer_Homo sapiens_hsa052060.77790877
83Glucagon signaling pathway_Homo sapiens_hsa049220.77761078
84Insulin signaling pathway_Homo sapiens_hsa049100.76450975
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76123984
86Fatty acid elongation_Homo sapiens_hsa000620.76102699
87Rap1 signaling pathway_Homo sapiens_hsa040150.75573493
88Lysine degradation_Homo sapiens_hsa003100.75571436
89Dilated cardiomyopathy_Homo sapiens_hsa054140.74810238
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74687225
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72991266
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72783384
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72353880
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71549959
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71007886
96Ovarian steroidogenesis_Homo sapiens_hsa049130.70415739
97Glioma_Homo sapiens_hsa052140.69238062
98Inositol phosphate metabolism_Homo sapiens_hsa005620.66988810
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.66014854
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65325898
101Vitamin B6 metabolism_Homo sapiens_hsa007500.65179846
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64982902
103Rheumatoid arthritis_Homo sapiens_hsa053230.64109571
104Fatty acid biosynthesis_Homo sapiens_hsa000610.63707721
105PPAR signaling pathway_Homo sapiens_hsa033200.62762515
106Small cell lung cancer_Homo sapiens_hsa052220.62323834
107Arginine and proline metabolism_Homo sapiens_hsa003300.62137528
108Histidine metabolism_Homo sapiens_hsa003400.61745883
109Mineral absorption_Homo sapiens_hsa049780.60655793
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60506018
111Sulfur metabolism_Homo sapiens_hsa009200.59338096
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58486539
113Pathways in cancer_Homo sapiens_hsa052000.58358099
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58306130
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.57251521
116Basal cell carcinoma_Homo sapiens_hsa052170.55371601
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54654504
118Hippo signaling pathway_Homo sapiens_hsa043900.54557554
119Cardiac muscle contraction_Homo sapiens_hsa042600.53502550
120Thyroid hormone synthesis_Homo sapiens_hsa049180.51927720
121Colorectal cancer_Homo sapiens_hsa052100.51887305
122ECM-receptor interaction_Homo sapiens_hsa045120.48548806
123Focal adhesion_Homo sapiens_hsa045100.47208869
124Alcoholism_Homo sapiens_hsa050340.47038505
125Chemokine signaling pathway_Homo sapiens_hsa040620.46741011
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46481545
127VEGF signaling pathway_Homo sapiens_hsa043700.46444825
128Melanoma_Homo sapiens_hsa052180.44664094
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44534318
130Phagosome_Homo sapiens_hsa041450.43360843
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43228074
132Proteoglycans in cancer_Homo sapiens_hsa052050.41227499
133Oocyte meiosis_Homo sapiens_hsa041140.40977208

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