EXOC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.50368945
2COPI coating of Golgi vesicle (GO:0048205)4.87337996
3Golgi transport vesicle coating (GO:0048200)4.87337996
4synaptic vesicle exocytosis (GO:0016079)4.79807073
5neurotransmitter-gated ion channel clustering (GO:0072578)4.78381137
6postsynaptic membrane organization (GO:0001941)4.58637868
7regulation of synaptic vesicle exocytosis (GO:2000300)4.40379854
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.33936374
9neuron cell-cell adhesion (GO:0007158)4.29601036
10vocalization behavior (GO:0071625)4.26807728
11synaptic vesicle maturation (GO:0016188)4.10812195
12protein localization to endosome (GO:0036010)4.07765505
13regulation of synaptic vesicle transport (GO:1902803)4.03905951
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.01630499
15locomotory exploration behavior (GO:0035641)3.86826491
16regulation of glutamate receptor signaling pathway (GO:1900449)3.84625686
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.84438528
18glutamate secretion (GO:0014047)3.81944260
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.81221899
20positive regulation of synapse maturation (GO:0090129)3.81064037
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.78877684
22semaphorin-plexin signaling pathway (GO:0071526)3.77682423
23cell communication by electrical coupling (GO:0010644)3.66430331
24protein localization to synapse (GO:0035418)3.64182887
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.64089502
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.59391348
27adherens junction assembly (GO:0034333)3.59373021
28positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.57501313
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52806178
30protein retention in ER lumen (GO:0006621)3.52566241
31response to pheromone (GO:0019236)3.52430606
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50622117
33negative regulation of cell size (GO:0045792)3.50538053
34mannose metabolic process (GO:0006013)3.46671944
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.45837232
36cell-substrate adherens junction assembly (GO:0007045)3.40574802
37focal adhesion assembly (GO:0048041)3.40574802
38regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.40434267
39presynaptic membrane assembly (GO:0097105)3.39319137
40barbed-end actin filament capping (GO:0051016)3.38522380
41neurotransmitter secretion (GO:0007269)3.35978289
42cerebellar granule cell differentiation (GO:0021707)3.33930236
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32275865
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.31132071
45cell-substrate junction assembly (GO:0007044)3.27765150
46basement membrane organization (GO:0071711)3.27456627
47regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24333884
48striatum development (GO:0021756)3.22897025
49regulation of extracellular matrix disassembly (GO:0010715)3.19047461
50regulation of synapse structural plasticity (GO:0051823)3.17604658
51negative regulation of erythrocyte differentiation (GO:0045647)3.16471436
52sodium ion export (GO:0071436)3.16207562
53auditory behavior (GO:0031223)3.14721056
54skin morphogenesis (GO:0043589)3.08922207
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.08565709
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03125768
57stress fiber assembly (GO:0043149)3.00629292
58urinary tract smooth muscle contraction (GO:0014848)3.00253969
59adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.00122434
60negative regulation of fatty acid transport (GO:2000192)2.99325356
61pyrimidine nucleobase catabolic process (GO:0006208)2.99156308
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.98286104
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98065001
64regulation of synapse maturation (GO:0090128)2.97221513
65exploration behavior (GO:0035640)2.97132080
66presynaptic membrane organization (GO:0097090)2.95455280
67long-term synaptic potentiation (GO:0060291)2.94622199
68NADH metabolic process (GO:0006734)2.92996886
69regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.92492470
70negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92358009
71cell migration in hindbrain (GO:0021535)2.90169279
72synapse assembly (GO:0007416)2.86686656
73response to auditory stimulus (GO:0010996)2.85507871
74membrane depolarization during action potential (GO:0086010)2.84596988
75activation of protein kinase A activity (GO:0034199)2.84540950
76female mating behavior (GO:0060180)2.84178865
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83499995
78ATP hydrolysis coupled proton transport (GO:0015991)2.83499995
79oxaloacetate metabolic process (GO:0006107)2.83186278
80cerebellar Purkinje cell layer development (GO:0021680)2.82322449
81epithelial cell-cell adhesion (GO:0090136)2.80762662
82regulation of glucose import in response to insulin stimulus (GO:2001273)2.79112095
83neuronal action potential propagation (GO:0019227)2.78613591
84innervation (GO:0060384)2.77431541
85mechanosensory behavior (GO:0007638)2.75562980
86inositol phosphate catabolic process (GO:0071545)2.74340820
87embryonic process involved in female pregnancy (GO:0060136)2.73809096
88cell-cell junction maintenance (GO:0045217)2.72792492
89synaptic vesicle endocytosis (GO:0048488)2.72100852
90positive regulation of synaptic transmission, GABAergic (GO:0032230)2.71965277
91proline transport (GO:0015824)2.71193507
92cellular potassium ion homeostasis (GO:0030007)2.70965646
93activation of Rac GTPase activity (GO:0032863)2.69853474
94regulation of neurotransmitter secretion (GO:0046928)2.68687552
95regulation of female receptivity (GO:0045924)2.67720400
96positive regulation of membrane potential (GO:0045838)2.67716152
97tricarboxylic acid cycle (GO:0006099)2.67092898
98regulation of beta-amyloid formation (GO:1902003)2.66909846
99neurotransmitter transport (GO:0006836)2.66098917
100hemidesmosome assembly (GO:0031581)2.66077672
101negative regulation of microtubule polymerization (GO:0031115)2.65771590
102positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.65694178
103regulation of ARF protein signal transduction (GO:0032012)2.65685175
104activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.65278438
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64828098
106positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.63726189
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.63528615
108transferrin transport (GO:0033572)2.62401353
109positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62197570
110regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62165598
111response to laminar fluid shear stress (GO:0034616)2.61100859
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60791421
113regulation of NFAT protein import into nucleus (GO:0051532)2.60419275
114epithelial cell differentiation involved in prostate gland development (GO:0060742)2.59222908
115neuromuscular synaptic transmission (GO:0007274)2.58728745
116regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.58144393
117maternal placenta development (GO:0001893)2.57438347
118regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.57302390
119negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57024195
120positive regulation of potassium ion transmembrane transport (GO:1901381)2.56708522
121vesicle coating (GO:0006901)2.56519160
122regulation of neuronal synaptic plasticity (GO:0048168)2.56428829
123positive regulation of receptor recycling (GO:0001921)2.56087616
124dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.56072070
125regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.55828899
126protein targeting to plasma membrane (GO:0072661)2.55296959
127regulation of neurotransmitter transport (GO:0051588)2.53980134
128regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.53257719
129synapse organization (GO:0050808)2.52984562
130regulation of membrane repolarization (GO:0060306)2.52885764
131cell communication involved in cardiac conduction (GO:0086065)2.52463325
132vascular endothelial growth factor signaling pathway (GO:0038084)2.52461809
133glutamate receptor signaling pathway (GO:0007215)2.52265497
134gonadal mesoderm development (GO:0007506)2.51821341
135establishment of synaptic vesicle localization (GO:0097480)2.51459821
136synaptic vesicle transport (GO:0048489)2.51459821
137regulation of cholesterol homeostasis (GO:2000188)2.51239206
138regulation of cell communication by electrical coupling (GO:0010649)2.50758329
139succinate metabolic process (GO:0006105)2.50541487
140positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.50250744
141regulation of amyloid precursor protein catabolic process (GO:1902991)2.49834377
142apoptotic process involved in morphogenesis (GO:0060561)2.49765506
143positive regulation of synapse assembly (GO:0051965)2.49553654
144positive regulation of synaptic transmission (GO:0050806)2.48814054
145dendrite morphogenesis (GO:0048813)2.48610253
146positive regulation of nuclease activity (GO:0032075)2.48311529
147glycogen catabolic process (GO:0005980)2.47206240
148cortical actin cytoskeleton organization (GO:0030866)2.46715734
149dopamine receptor signaling pathway (GO:0007212)2.45835609
150endothelial cell chemotaxis (GO:0035767)2.42154757
151intracellular estrogen receptor signaling pathway (GO:0030520)2.41636885
152regulation of ARF GTPase activity (GO:0032312)2.37249143
153retrograde transport, endosome to Golgi (GO:0042147)2.36594819
154cellular response to prostaglandin stimulus (GO:0071379)2.35348356
155actin filament depolymerization (GO:0030042)2.32964427
156Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.29736783
157pinocytosis (GO:0006907)2.29540513
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27966763
159regulation of early endosome to late endosome transport (GO:2000641)2.27288148
160positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.27194204
161apoptotic cell clearance (GO:0043277)2.26386050
162cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.26064447
163actin filament bundle organization (GO:0061572)2.23820881
164actin filament bundle assembly (GO:0051017)2.23820881
165regulation of extracellular matrix organization (GO:1903053)2.23658678
166layer formation in cerebral cortex (GO:0021819)2.23402404
167cortical cytoskeleton organization (GO:0030865)2.23326364
168cellular response to epidermal growth factor stimulus (GO:0071364)2.23237189
169stress granule assembly (GO:0034063)2.23061155
170endoplasmic reticulum unfolded protein response (GO:0030968)2.22555393
171regulation of establishment of planar polarity (GO:0090175)2.21695635
172cell adhesion mediated by integrin (GO:0033627)2.21104153
173histone H4 deacetylation (GO:0070933)2.19355468
174cell volume homeostasis (GO:0006884)2.19164037
175regulation of cholesterol biosynthetic process (GO:0045540)2.18653511
176negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.18120265
177alpha-linolenic acid metabolic process (GO:0036109)2.18062318
178desmosome organization (GO:0002934)2.17632609
179atrioventricular valve morphogenesis (GO:0003181)2.17125284
180modulation by virus of host morphology or physiology (GO:0019048)2.16279815
181regulation of nuclease activity (GO:0032069)2.16205310
182UV protection (GO:0009650)2.15268907
183membrane protein ectodomain proteolysis (GO:0006509)2.13867606
184negative regulation of myotube differentiation (GO:0010832)2.13795852
185adherens junction organization (GO:0034332)2.12969448
186ER-nucleus signaling pathway (GO:0006984)2.12403997
187positive regulation of Cdc42 GTPase activity (GO:0043089)2.12022364
188protein heterotrimerization (GO:0070208)2.11820471
189spliceosomal tri-snRNP complex assembly (GO:0000244)2.11463350
190negative regulation of catenin import into nucleus (GO:0035414)2.10872692
191proline biosynthetic process (GO:0006561)2.10699948
192eye morphogenesis (GO:0048592)2.08722828
193endodermal cell differentiation (GO:0035987)2.08353535
194regulation of fatty acid beta-oxidation (GO:0031998)2.07783410
195peptidyl-proline hydroxylation (GO:0019511)2.07615733
1963-UTR-mediated mRNA stabilization (GO:0070935)2.07599736
197activation of JUN kinase activity (GO:0007257)2.06740130
198embryo implantation (GO:0007566)2.06043413
199branching involved in mammary gland duct morphogenesis (GO:0060444)2.05888751
200convergent extension (GO:0060026)2.04537192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04833761
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.74409322
3GBX2_23144817_ChIP-Seq_PC3_Human3.31935755
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00842704
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91606912
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89846896
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76033893
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.63777445
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63276807
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.62665302
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49336421
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.45919784
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.44972932
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44389559
15DROSHA_22980978_ChIP-Seq_HELA_Human2.43948704
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43832453
17REST_21632747_ChIP-Seq_MESCs_Mouse2.43381448
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40531273
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36345214
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34063062
21AR_21572438_ChIP-Seq_LNCaP_Human2.33808365
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.33673883
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.31308345
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29864786
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29864786
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.26065272
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.25785041
28VDR_21846776_ChIP-Seq_THP-1_Human2.24154399
29CLOCK_20551151_ChIP-Seq_293T_Human2.22955262
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21559598
31RACK7_27058665_Chip-Seq_MCF-7_Human2.20405694
32MYC_22102868_ChIP-Seq_BL_Human2.16502819
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15952947
34KDM2B_26808549_Chip-Seq_DND41_Human2.12760806
35TCF7_22412390_ChIP-Seq_EML_Mouse2.12752046
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11679371
37KDM2B_26808549_Chip-Seq_K562_Human2.11173168
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05236106
39ESR2_21235772_ChIP-Seq_MCF-7_Human2.01372914
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98819919
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97306755
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.96010898
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.95985890
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89395780
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85019007
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.83178833
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82096631
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.74603217
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74129555
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73164210
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.70211640
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68411065
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65279103
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61094481
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.60928653
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.59697284
57ZNF263_19887448_ChIP-Seq_K562_Human1.59647554
58ZNF274_21170338_ChIP-Seq_K562_Hela1.58341643
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58247892
60TP53_22127205_ChIP-Seq_IMR90_Human1.57371228
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55568230
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55486110
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54816642
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54669885
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52167414
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51009888
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.49927288
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46743835
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46469115
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43949023
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43761087
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43500790
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43089231
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41892071
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40082735
76SMC4_20622854_ChIP-Seq_HELA_Human1.39045401
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37027820
78* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36995910
79CREB1_26743006_Chip-Seq_LNCaP_Human1.36565663
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33975552
81* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33135867
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31803606
83* TET1_21451524_ChIP-Seq_MESCs_Mouse1.29664062
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.28470769
85SMAD4_21799915_ChIP-Seq_A2780_Human1.28130884
86P68_20966046_ChIP-Seq_HELA_Human1.28063445
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27731750
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26015449
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.25796163
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25577102
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23031519
92TAF15_26573619_Chip-Seq_HEK293_Human1.22130018
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.21719695
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21424325
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21186999
96* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19104908
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19076732
98AR_25329375_ChIP-Seq_VCAP_Human1.18471954
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.18177418
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.16821710
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16654488
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16504006
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16382655
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16074094
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16005162
106ATF3_27146783_Chip-Seq_COLON_Human1.14955724
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14925634
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14096043
109VDR_24763502_ChIP-Seq_THP-1_Human1.14032110
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.13083369
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12803517
112UBF1/2_26484160_Chip-Seq_HMECs_Human1.12667051
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12135049
114TBX20_22080862_ChIP-Seq_HEART_Mouse1.12014390
115TBX20_22328084_ChIP-Seq_HEART_Mouse1.12014390
116P300_19829295_ChIP-Seq_ESCs_Human1.11233279
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11023432
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10014272
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09961456
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09444556
121MAF_26560356_Chip-Seq_TH1_Human1.07904849
122ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07203050
123AR_19668381_ChIP-Seq_PC3_Human1.06657292
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06479063
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05642292
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05417957
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04850237
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04770091
129SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04712244
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04697615
131TP53_23651856_ChIP-Seq_MEFs_Mouse1.04012377
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03958918
133RUNX1_22412390_ChIP-Seq_EML_Mouse1.03180574
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02132436
135SMAD3_21741376_ChIP-Seq_ESCs_Human1.01659604
136WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01476965
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99414524
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99101797
139* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98539514
140SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98372976
141KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98219157
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97994956
143UTX_26944678_Chip-Seq_JUKART_Human0.97632555
144NCOR1_26117541_ChIP-Seq_K562_Human0.97588773
145NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97447101
146CBP_20019798_ChIP-Seq_JUKART_Human0.97312803
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97312803
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97191114
149* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96874352
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96230655
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95806012
152TP53_20018659_ChIP-ChIP_R1E_Mouse0.95199188
153SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95164191
154MAF_26560356_Chip-Seq_TH2_Human0.95124666
155CTCF_27219007_Chip-Seq_Bcells_Human0.95015857
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.92894587
157ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92102637
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.92027696
159* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91035488
160RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88974894
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.88714404
162BCAT_22108803_ChIP-Seq_LS180_Human0.88432191
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.87532426
164LXR_22292898_ChIP-Seq_THP-1_Human0.86904212
165WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86889934
166SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86447357
167NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86057509
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86035931
169AHR_22903824_ChIP-Seq_MCF-7_Human0.85353191
170TET1_21490601_ChIP-Seq_MESCs_Mouse0.85100163
171* STAT3_23295773_ChIP-Seq_U87_Human0.84421278
172PRDM14_20953172_ChIP-Seq_ESCs_Human0.84162744
173TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83760070
174P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81952784
175BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80782260
176PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80031155
177PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78283188
178TCF4_23295773_ChIP-Seq_U87_Human0.78010020
179SOX9_26525672_Chip-Seq_HEART_Mouse0.77702269
180FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77222794
181WDR5_24793694_ChIP-Seq_LNCAP_Human0.76898822
182PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76681115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.88001401
2MP0004859_abnormal_synaptic_plasticity4.16830398
3MP0008438_abnormal_cutaneous_collagen3.82355660
4MP0003880_abnormal_central_pattern3.38176358
5MP0003566_abnormal_cell_adhesion3.23264987
6MP0003635_abnormal_synaptic_transmissio3.11705135
7MP0005645_abnormal_hypothalamus_physiol2.83125272
8MP0002736_abnormal_nociception_after2.69631047
9MP0005058_abnormal_lysosome_morphology2.64756750
10MP0001968_abnormal_touch/_nociception2.64217103
11MP0002822_catalepsy2.63788345
12MP0001849_ear_inflammation2.61629946
13MP0005257_abnormal_intraocular_pressure2.60413920
14MP0000751_myopathy2.56718570
15MP0003183_abnormal_peptide_metabolism2.56546179
16MP0001958_emphysema2.53307510
17MP0002063_abnormal_learning/memory/cond2.49480462
18MP0000013_abnormal_adipose_tissue2.47235546
19MP0009745_abnormal_behavioral_response2.43253071
20MP0004270_analgesia2.42409086
21MP0002837_dystrophic_cardiac_calcinosis2.39829523
22MP0004858_abnormal_nervous_system2.36321362
23MP0004272_abnormal_basement_membrane2.32509744
24MP0002064_seizures2.31466376
25MP0009780_abnormal_chondrocyte_physiolo2.31100197
26MP0005076_abnormal_cell_differentiation2.27122195
27MP0003091_abnormal_cell_migration2.26362481
28MP0008260_abnormal_autophagy2.22960989
29MP0002734_abnormal_mechanical_nocicepti2.22111537
30MP0001984_abnormal_olfaction2.19719153
31MP0002877_abnormal_melanocyte_morpholog2.11324438
32MP0002572_abnormal_emotion/affect_behav2.10475695
33MP0003191_abnormal_cellular_cholesterol2.08252467
34MP0002735_abnormal_chemical_nociception2.07062573
35MP0006276_abnormal_autonomic_nervous2.06880743
36MP0003279_aneurysm2.05315075
37MP0002909_abnormal_adrenal_gland2.01340224
38MP0008569_lethality_at_weaning1.89191534
39MP0003300_gastrointestinal_ulcer1.89159492
40MP0001348_abnormal_lacrimal_gland1.88430164
41MP0003329_amyloid_beta_deposits1.87132363
42MP0009046_muscle_twitch1.85482910
43MP0005423_abnormal_somatic_nervous1.85238655
44MP0005646_abnormal_pituitary_gland1.83415858
45MP0003122_maternal_imprinting1.81535329
46MP0000537_abnormal_urethra_morphology1.81079072
47MP0002272_abnormal_nervous_system1.81067813
48MP0005451_abnormal_body_composition1.75926460
49MP0002067_abnormal_sensory_capabilities1.75394700
50MP0001502_abnormal_circadian_rhythm1.69223596
51MP0004185_abnormal_adipocyte_glucose1.67409550
52MP0005275_abnormal_skin_tensile1.67195169
53MP0002557_abnormal_social/conspecific_i1.63601311
54MP0009384_cardiac_valve_regurgitation1.62377102
55MP0001970_abnormal_pain_threshold1.60660658
56MP0001486_abnormal_startle_reflex1.58751154
57MP0000733_abnormal_muscle_development1.57776573
58MP0004036_abnormal_muscle_relaxation1.57678569
59MP0002184_abnormal_innervation1.57205311
60MP0000749_muscle_degeneration1.53849197
61MP0009840_abnormal_foam_cell1.52909307
62MP0002733_abnormal_thermal_nociception1.51902357
63MP0002138_abnormal_hepatobiliary_system1.50869916
64MP0004811_abnormal_neuron_physiology1.50814938
65MP0005623_abnormal_meninges_morphology1.49322476
66MP0003646_muscle_fatigue1.44224816
67MP0004145_abnormal_muscle_electrophysio1.43871540
68MP0000767_abnormal_smooth_muscle1.42965002
69MP0001440_abnormal_grooming_behavior1.42216283
70MP0002876_abnormal_thyroid_physiology1.40125267
71MP0003787_abnormal_imprinting1.39490173
72MP0004264_abnormal_extraembryonic_tissu1.37826066
73MP0004233_abnormal_muscle_weight1.35193848
74MP0004130_abnormal_muscle_cell1.35051033
75MP0005503_abnormal_tendon_morphology1.34528749
76MP0001188_hyperpigmentation1.34332964
77MP0005023_abnormal_wound_healing1.33802179
78MP0003879_abnormal_hair_cell1.30732044
79MP0003453_abnormal_keratinocyte_physiol1.30625025
80MP0002060_abnormal_skin_morphology1.29855890
81MP0001501_abnormal_sleep_pattern1.27515218
82MP0002896_abnormal_bone_mineralization1.27000432
83MP0010368_abnormal_lymphatic_system1.26766936
84MP0000858_altered_metastatic_potential1.26080039
85MP0003115_abnormal_respiratory_system1.24746496
86MP0010386_abnormal_urinary_bladder1.23299989
87MP0001915_intracranial_hemorrhage1.23251451
88MP0005375_adipose_tissue_phenotype1.22679770
89MP0000955_abnormal_spinal_cord1.20997114
90MP0004084_abnormal_cardiac_muscle1.20147459
91MP0002089_abnormal_postnatal_growth/wei1.19046011
92MP0005666_abnormal_adipose_tissue1.17870372
93MP0002882_abnormal_neuron_morphology1.17511244
94MP0004085_abnormal_heartbeat1.16972788
95MP0010234_abnormal_vibrissa_follicle1.16963577
96MP0002066_abnormal_motor_capabilities/c1.16152067
97MP0003436_decreased_susceptibility_to1.10930657
98MP0009278_abnormal_bone_marrow1.10121576
99MP0000778_abnormal_nervous_system1.09992703
100MP0005551_abnormal_eye_electrophysiolog1.09633024
101MP0004924_abnormal_behavior1.08445870
102MP0005386_behavior/neurological_phenoty1.08445870
103MP0002249_abnormal_larynx_morphology1.08343752
104MP0004215_abnormal_myocardial_fiber1.05758350
105MP0003385_abnormal_body_wall1.04780186
106MP0003942_abnormal_urinary_system1.04130053
107MP0000003_abnormal_adipose_tissue1.03314007
108MP0004947_skin_inflammation1.03222298
109MP0005620_abnormal_muscle_contractility1.02183837
110MP0003633_abnormal_nervous_system1.00970052
111MP0004087_abnormal_muscle_fiber1.00001386
112MP0010030_abnormal_orbit_morphology0.99455919
113MP0010630_abnormal_cardiac_muscle0.98750308
114MP0000631_abnormal_neuroendocrine_gland0.98729240
115MP0006138_congestive_heart_failure0.98135542
116MP0005621_abnormal_cell_physiology0.97018658
117MP0002069_abnormal_eating/drinking_beha0.95396383
118MP0000747_muscle_weakness0.94114446
119MP0010352_gastrointestinal_tract_polyps0.93313100
120MP0000534_abnormal_ureter_morphology0.91690794
121MP0005508_abnormal_skeleton_morphology0.91313713
122MP0001664_abnormal_digestion0.90075123
123MP0000759_abnormal_skeletal_muscle0.89232122
124MP0005409_darkened_coat_color0.88816083
125MP0008872_abnormal_physiological_respon0.88190889
126MP0005535_abnormal_body_temperature0.87968091
127MP0000230_abnormal_systemic_arterial0.86730239
128MP0002269_muscular_atrophy0.86570332
129MP0002998_abnormal_bone_remodeling0.86298456
130MP0001299_abnormal_eye_distance/0.85545894
131MP0006072_abnormal_retinal_apoptosis0.85373685
132MP0005501_abnormal_skin_physiology0.85285502
133MP0001614_abnormal_blood_vessel0.83434738
134MP0002234_abnormal_pharynx_morphology0.83402898
135MP0001270_distended_abdomen0.83138506
136MP0002108_abnormal_muscle_morphology0.82876616
137MP0009053_abnormal_anal_canal0.82687836
138MP0008961_abnormal_basal_metabolism0.82553375
139MP0002925_abnormal_cardiovascular_devel0.81888076
140MP0001905_abnormal_dopamine_level0.81604670
141MP0003690_abnormal_glial_cell0.81378601
142MP0002152_abnormal_brain_morphology0.80649653
143MP0001986_abnormal_taste_sensitivity0.80529267
144MP0002229_neurodegeneration0.80431367
145MP0002090_abnormal_vision0.80337319
146MP0003137_abnormal_impulse_conducting0.80290843
147MP0003631_nervous_system_phenotype0.79536839
148MP0002933_joint_inflammation0.79373646
149MP0005248_abnormal_Harderian_gland0.79170379
150MP0000678_abnormal_parathyroid_gland0.78385123
151MP0000750_abnormal_muscle_regeneration0.77023478
152MP0000428_abnormal_craniofacial_morphol0.76954715
153MP0002972_abnormal_cardiac_muscle0.76657721
154MP0002078_abnormal_glucose_homeostasis0.75999519
155MP0005448_abnormal_energy_balance0.75837242
156MP0003634_abnormal_glial_cell0.75832266
157MP0002009_preneoplasia0.75685465
158MP0002796_impaired_skin_barrier0.74192931
159MP0000604_amyloidosis0.73741715
160MP0003172_abnormal_lysosome_physiology0.73570949
161MP0003303_peritoneal_inflammation0.73568767
162MP0005394_taste/olfaction_phenotype0.73462845
163MP0005499_abnormal_olfactory_system0.73462845
164MP0004510_myositis0.73374075
165MP0000467_abnormal_esophagus_morphology0.72472424
166MP0002653_abnormal_ependyma_morphology0.70662316
167MP0002928_abnormal_bile_duct0.70115042
168MP0000762_abnormal_tongue_morphology0.69315221
169MP0002092_abnormal_eye_morphology0.67956823
170MP0002116_abnormal_craniofacial_bone0.67315534
171MP0001175_abnormal_lung_morphology0.67256400
172MP0002128_abnormal_blood_circulation0.64247899
173MP0002086_abnormal_extraembryonic_tissu0.63931451
174MP0001533_abnormal_skeleton_physiology0.63893043
175MP0002113_abnormal_skeleton_development0.63502496
176MP0000681_abnormal_thyroid_gland0.63427519
177MP0009672_abnormal_birth_weight0.63389884
178MP0005390_skeleton_phenotype0.62993061
179MP0003828_pulmonary_edema0.62710256

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.32362100
2Protrusio acetabuli (HP:0003179)4.19079111
3Epileptic encephalopathy (HP:0200134)4.18501770
4Focal motor seizures (HP:0011153)3.97151051
5Premature rupture of membranes (HP:0001788)3.86486033
6Ankle clonus (HP:0011448)3.82159736
7Pheochromocytoma (HP:0002666)3.71605567
8Visual hallucinations (HP:0002367)3.53439991
9Myokymia (HP:0002411)3.50528073
10Hyperacusis (HP:0010780)3.44377310
11Supranuclear gaze palsy (HP:0000605)3.34508270
12Hyperventilation (HP:0002883)3.24753723
13Neuroendocrine neoplasm (HP:0100634)3.19792023
14Cerebral aneurysm (HP:0004944)3.09026259
15Cervical subluxation (HP:0003308)3.02526375
16Oligomenorrhea (HP:0000876)2.99017896
17Atonic seizures (HP:0010819)2.97853147
18Febrile seizures (HP:0002373)2.93301908
19Broad face (HP:0000283)2.91862823
20Depression (HP:0000716)2.91698254
21Impaired vibration sensation in the lower limbs (HP:0002166)2.89126259
22Shallow orbits (HP:0000586)2.77771293
23Flat acetabular roof (HP:0003180)2.72847384
24Focal seizures (HP:0007359)2.71780309
25Vertebral compression fractures (HP:0002953)2.68528452
26Distal lower limb amyotrophy (HP:0008944)2.63811422
27Gait imbalance (HP:0002141)2.63564598
28Menstrual irregularities (HP:0000858)2.63423059
29Ulnar bowing (HP:0003031)2.61866230
30Poor suck (HP:0002033)2.61821578
31Epileptiform EEG discharges (HP:0011182)2.57190761
32Arterial tortuosity (HP:0005116)2.56895626
33Obstructive sleep apnea (HP:0002870)2.54240988
34Myotonia (HP:0002486)2.52315620
35Agitation (HP:0000713)2.50902488
36Absence seizures (HP:0002121)2.49735399
37Vascular tortuosity (HP:0004948)2.49535472
38Nephrogenic diabetes insipidus (HP:0009806)2.47247612
39EEG with generalized epileptiform discharges (HP:0011198)2.47174743
40Lower limb muscle weakness (HP:0007340)2.45773575
41Ketoacidosis (HP:0001993)2.44693995
42Increased connective tissue (HP:0009025)2.43673879
43Asymmetry of the thorax (HP:0001555)2.43447442
44Hepatocellular necrosis (HP:0001404)2.43178214
45Fetal akinesia sequence (HP:0001989)2.39009384
46Medial flaring of the eyebrow (HP:0010747)2.38868678
47Bladder diverticulum (HP:0000015)2.38747149
48Hypercortisolism (HP:0001578)2.37986686
49Exercise-induced muscle cramps (HP:0003710)2.36154317
50Spinal canal stenosis (HP:0003416)2.33390500
51Hypsarrhythmia (HP:0002521)2.33280098
52Broad-based gait (HP:0002136)2.32165457
53Progressive cerebellar ataxia (HP:0002073)2.31558470
54Atrophic scars (HP:0001075)2.31451891
55Short nail (HP:0001799)2.31017392
56Mitral regurgitation (HP:0001653)2.30357187
57Polyphagia (HP:0002591)2.29000619
58Urinary urgency (HP:0000012)2.28477241
59Neoplasm of the peripheral nervous system (HP:0100007)2.28435290
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.27965494
61Abnormal hair whorl (HP:0010721)2.27248754
62Long toe (HP:0010511)2.26403332
63Distal upper limb amyotrophy (HP:0007149)2.25899839
64Upper limb amyotrophy (HP:0009129)2.25899839
65Truncal ataxia (HP:0002078)2.25773847
66Wormian bones (HP:0002645)2.25043443
67Thin bony cortex (HP:0002753)2.25015059
68Congenital primary aphakia (HP:0007707)2.24795486
69Aneurysm (HP:0002617)2.24501146
70Generalized tonic-clonic seizures (HP:0002069)2.23285624
71Abnormal eating behavior (HP:0100738)2.22781233
72Interstitial pulmonary disease (HP:0006530)2.22586406
73Spastic gait (HP:0002064)2.22433169
74Aortic dissection (HP:0002647)2.21877575
75Muscle hypertrophy of the lower extremities (HP:0008968)2.21192143
76Aortic aneurysm (HP:0004942)2.20917536
77Spinal rigidity (HP:0003306)2.20407233
78Disproportionate tall stature (HP:0001519)2.20068890
79Anxiety (HP:0000739)2.19824388
80Myoglobinuria (HP:0002913)2.19259819
81Blue sclerae (HP:0000592)2.18187869
82Ankle contracture (HP:0006466)2.14645887
83Fragile skin (HP:0001030)2.14127814
84Insomnia (HP:0100785)2.13426740
85Dilatation of the ascending aorta (HP:0005111)2.12906227
86Narrow nasal bridge (HP:0000446)2.11796179
87Biconcave vertebral bodies (HP:0004586)2.11065320
88Blue irides (HP:0000635)2.09213732
89Growth hormone excess (HP:0000845)2.09144401
90Postural instability (HP:0002172)2.09020674
91Left ventricular hypertrophy (HP:0001712)2.08902948
92Broad metatarsal (HP:0001783)2.08618085
93Cerebral inclusion bodies (HP:0100314)2.07554762
94Central scotoma (HP:0000603)2.06470678
95Urinary bladder sphincter dysfunction (HP:0002839)2.06427132
96Calf muscle hypertrophy (HP:0008981)2.06423726
97Progressive inability to walk (HP:0002505)2.06263167
98Ventricular fibrillation (HP:0001663)2.05848143
99Deep venous thrombosis (HP:0002625)2.05791785
100Abnormality of the lower motor neuron (HP:0002366)2.04721144
101Limb-girdle muscle atrophy (HP:0003797)2.03626612
102Athetosis (HP:0002305)2.02682980
103Failure to thrive in infancy (HP:0001531)2.02679610
104Prolonged QT interval (HP:0001657)2.02654370
105Abnormality of the distal phalanx of the thumb (HP:0009617)2.02233036
106Impaired pain sensation (HP:0007328)2.02172799
107Abnormality of pain sensation (HP:0010832)2.02172799
108Abnormality of the calf musculature (HP:0001430)2.02113333
109Increased variability in muscle fiber diameter (HP:0003557)2.01086334
110Hypoventilation (HP:0002791)2.00766558
111Difficulty climbing stairs (HP:0003551)2.00201029
112Hepatic necrosis (HP:0002605)1.99428908
113Achilles tendon contracture (HP:0001771)1.99305329
114Hypothermia (HP:0002045)1.99088162
115Cholecystitis (HP:0001082)1.98918006
116Abnormal gallbladder physiology (HP:0012438)1.98918006
117Hypoplasia of the brainstem (HP:0002365)1.98239389
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98239389
119Hemorrhage of the eye (HP:0011885)1.98092052
120Mildly elevated creatine phosphokinase (HP:0008180)1.97285710
121Drooling (HP:0002307)1.96104807
122Excessive salivation (HP:0003781)1.96104807
123Hemiplegia (HP:0002301)1.95162660
124Lower limb amyotrophy (HP:0007210)1.94667540
125Poor eye contact (HP:0000817)1.94406182
126Dysmetric saccades (HP:0000641)1.94185021
127Turricephaly (HP:0000262)1.93961838
128Mitral valve prolapse (HP:0001634)1.93648209
129Lissencephaly (HP:0001339)1.93480139
130Dysdiadochokinesis (HP:0002075)1.92868299
131Torticollis (HP:0000473)1.92799423
132Advanced eruption of teeth (HP:0006288)1.92738060
133Peritonitis (HP:0002586)1.92695342
134Genu recurvatum (HP:0002816)1.91017764
135Dialeptic seizures (HP:0011146)1.89179941
136Joint laxity (HP:0001388)1.89162379
137Emotional lability (HP:0000712)1.87609972
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.87602366
139Long palpebral fissure (HP:0000637)1.87326687
140Distal lower limb muscle weakness (HP:0009053)1.86691447
141Abnormality of skeletal muscle fiber size (HP:0012084)1.86638327
142Neurofibrillary tangles (HP:0002185)1.85597344
143Hand muscle atrophy (HP:0009130)1.85381165
144Bronchomalacia (HP:0002780)1.85106258
145EMG: myopathic abnormalities (HP:0003458)1.84628326
146Rimmed vacuoles (HP:0003805)1.84307014
147Pointed chin (HP:0000307)1.83600677
148Abnormal social behavior (HP:0012433)1.83224714
149Impaired social interactions (HP:0000735)1.83224714
150Sudden death (HP:0001699)1.83160675
151Dislocated radial head (HP:0003083)1.82641934
152Natal tooth (HP:0000695)1.82559367
153Abnormal ossification of hand bones (HP:0005921)1.82230534
154Spinal cord lesions (HP:0100561)1.81622273
155Syringomyelia (HP:0003396)1.81622273
156Sleep apnea (HP:0010535)1.81535329
157Neonatal short-limb short stature (HP:0008921)1.81347707
158Abnormality of the Achilles tendon (HP:0005109)1.81244325
159Muscle stiffness (HP:0003552)1.80780793
160Hemiparesis (HP:0001269)1.80744364
161Impaired vibratory sensation (HP:0002495)1.80624900
162Focal dystonia (HP:0004373)1.80041164
163Psychosis (HP:0000709)1.79472231
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78889910
165Precocious puberty (HP:0000826)1.78038954
166Mitral stenosis (HP:0001718)1.77926669
167Abnormality of dentin (HP:0010299)1.76836997
168Neoplasm of the heart (HP:0100544)1.74957306
169Craniofacial dystonia (HP:0012179)1.74852941
170Lymphangioma (HP:0100764)1.74744803
171Dysostosis multiplex (HP:0000943)1.73224692
172Mucopolysacchariduria (HP:0008155)1.71944770
173Urinary glycosaminoglycan excretion (HP:0003541)1.71944770
174Abnormality of the radial head (HP:0003995)1.71689906
175Metaphyseal cupping (HP:0003021)1.70797375
176Abnormality of the thoracic spine (HP:0100711)1.69926525
177Abnormality of the distal phalanges of the toes (HP:0010182)1.69594878
178Abnormality of carpal bone ossification (HP:0006257)1.68511706
179Stridor (HP:0010307)1.68086641
180Osteolytic defects of the phalanges of the hand (HP:0009771)1.67650881
181Osteolytic defects of the hand bones (HP:0009699)1.67650881
182Hyperextensible skin (HP:0000974)1.64894140
183Vertebral arch anomaly (HP:0008438)1.64636774
184Patellar dislocation (HP:0002999)1.64437779
185Abnormality of the acetabulum (HP:0003170)1.64162638
186Coxa vara (HP:0002812)1.60483746
187Abnormality of glycosaminoglycan metabolism (HP:0004371)1.59315826
188Abnormality of mucopolysaccharide metabolism (HP:0011020)1.59315826
189Abnormality of polysaccharide metabolism (HP:0011012)1.59315826
190Bowel diverticulosis (HP:0005222)1.58379644
191Back pain (HP:0003418)1.57769562
192Broad palm (HP:0001169)1.57686551
193Hammertoe (HP:0001765)1.55785117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.99168506
2ICK3.12077147
3MAP3K42.85287885
4PHKG22.69868593
5PHKG12.69868593
6RIPK12.64485910
7SMG12.49966553
8NTRK32.48494794
9PRPF4B2.42754016
10DAPK22.39614684
11PDGFRA2.38957241
12MAP2K72.38719385
13MARK12.38027821
14CDK122.22052949
15MAP3K122.13492500
16EPHA22.02197385
17PRKD31.99147209
18MAPK131.94958084
19EPHB11.88898358
20MINK11.83633145
21CDK191.75026700
22TRIB31.71343702
23SGK2231.65151479
24SGK4941.65151479
25PDK31.61292263
26PDK41.61292263
27SGK21.53094974
28PTK21.52219479
29MAP2K31.51072495
30LMTK21.50403798
31MAP3K91.43874230
32MARK21.43304659
33SIK21.39000942
34DAPK11.37476928
35MAP2K41.37162314
36AKT31.36164684
37MTOR1.28657292
38PRKD21.28047938
39PTK2B1.26365705
40SGK31.25666630
41CAMKK11.23827764
42CAMKK21.23730074
43PTK61.22236684
44RPS6KA21.21431843
45CDK51.21093235
46CCNB11.20275455
47IRAK31.20074634
48MAP3K61.19832581
49PAK61.18470853
50NTRK21.17125323
51EPHA41.16516949
52EEF2K1.15336562
53PRKCH1.10976338
54MAP3K101.10562788
55PAK41.10181686
56MST1R1.09450381
57BRAF1.09126227
58TTN1.08888547
59STK381.08063344
60KSR11.05516886
61DYRK1B1.03263043
62TYRO31.01905421
63CDK81.01423143
64MET1.01412430
65DDR21.00849573
66LATS21.00673376
67PRKCG1.00114627
68EPHA30.99302012
69ARAF0.98123500
70TNIK0.97757613
71FGFR30.96921940
72MAP3K30.96535551
73NME10.95215574
74CAMK1D0.93667338
75PKN20.93043893
76PAK30.92097093
77SCYL20.91245459
78EPHB20.87626807
79ZAP700.87607080
80TSSK60.87578978
81SIK30.87404496
82PDGFRB0.86253743
83ERBB30.83471113
84CDK180.81318949
85PLK20.81300290
86RPS6KL10.76857863
87RPS6KC10.76857863
88PINK10.74806732
89CDK150.74652874
90PDPK10.73209753
91GRK50.72034856
92CDK60.71576009
93MAPKAPK50.70739210
94CDK140.69818026
95NEK10.69382801
96MAP3K110.68787086
97CDK11A0.68557441
98BMX0.68556064
99MAPK120.67148882
100KSR20.67092422
101WNK30.66964741
102ROCK10.65131349
103PAK20.64851151
104DMPK0.63517035
105MAP3K70.62338686
106RET0.62315244
107FER0.62065351
108PDK20.61868366
109MAP3K10.61555483
110ILK0.61223270
111CAMK1G0.60824357
112TYK20.60741608
113CAMK2A0.60473101
114DAPK30.59660362
115HIPK20.59392712
116JAK10.58739391
117CAMK10.58422846
118NEK90.57458140
119UHMK10.57044252
120TESK20.56804898
121BCKDK0.56543366
122MAP2K10.56500924
123DYRK1A0.54703491
124MAP3K130.54674284
125TBK10.54032956
126FES0.53547620
127MYLK0.52657539
128MAP3K20.52545699
129ERN10.52202842
130SIK10.52093008
131MAP2K60.52087647
132RPS6KA60.50987915
133CAMK2G0.50909811
134TESK10.50115547
135LRRK20.48382296
136TAOK10.48217356
137NTRK10.47910473
138ROCK20.47584394
139CAMK2B0.46839410
140ADRBK10.46738917
141LATS10.45159549
142FGFR40.44844717
143CDC42BPA0.44110758
144MAPK110.43836145
145CAMK2D0.43706363
146PRKCE0.43603480
147OBSCN0.43092792
148BRSK10.42699794
149TAOK20.42695389
150PRKCZ0.42121633
151CDK90.41407513
152PRKD10.40147675
153BRD40.38690387
154JAK30.37162620
155PDK10.35861068
156LIMK10.34727897
157SRC0.32940613
158CDK40.32680435
159PIM20.32172876
160CDK70.32125467
161PRKAA10.30235446
162MAPK100.29994622
163CAMK40.29709207
164ERBB20.29301995
165GRK60.29171408

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.76169760
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70881984
3Nicotine addiction_Homo sapiens_hsa050332.55979148
4Olfactory transduction_Homo sapiens_hsa047402.55838501
5Insulin secretion_Homo sapiens_hsa049112.21666234
6Morphine addiction_Homo sapiens_hsa050322.18982461
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14900471
8Circadian entrainment_Homo sapiens_hsa047132.14847998
9Collecting duct acid secretion_Homo sapiens_hsa049662.14136225
10GABAergic synapse_Homo sapiens_hsa047272.11724979
11Vibrio cholerae infection_Homo sapiens_hsa051102.05695349
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01991307
13Amphetamine addiction_Homo sapiens_hsa050311.95417886
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.94055340
15Chronic myeloid leukemia_Homo sapiens_hsa052201.84874006
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.82842518
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80932265
18Dopaminergic synapse_Homo sapiens_hsa047281.78785315
19Notch signaling pathway_Homo sapiens_hsa043301.78277531
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64680080
21Non-small cell lung cancer_Homo sapiens_hsa052231.63243246
22Focal adhesion_Homo sapiens_hsa045101.59871969
23Cocaine addiction_Homo sapiens_hsa050301.59458162
24Long-term potentiation_Homo sapiens_hsa047201.58100805
25Glutamatergic synapse_Homo sapiens_hsa047241.53850565
26VEGF signaling pathway_Homo sapiens_hsa043701.52449573
27Endometrial cancer_Homo sapiens_hsa052131.52101567
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48853805
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48333122
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47938484
31Acute myeloid leukemia_Homo sapiens_hsa052211.47881246
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47188170
33Renin secretion_Homo sapiens_hsa049241.46809167
34ECM-receptor interaction_Homo sapiens_hsa045121.46427452
35Pancreatic cancer_Homo sapiens_hsa052121.44866208
36Gastric acid secretion_Homo sapiens_hsa049711.44287625
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42295155
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41608642
39Oxytocin signaling pathway_Homo sapiens_hsa049211.38974548
40Salivary secretion_Homo sapiens_hsa049701.37334735
41Bladder cancer_Homo sapiens_hsa052191.36460379
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36362322
43Cholinergic synapse_Homo sapiens_hsa047251.34994514
44Cardiac muscle contraction_Homo sapiens_hsa042601.32447908
45Calcium signaling pathway_Homo sapiens_hsa040201.29676740
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26750779
47Proteoglycans in cancer_Homo sapiens_hsa052051.26206088
48Circadian rhythm_Homo sapiens_hsa047101.25309077
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.24945219
50Pyruvate metabolism_Homo sapiens_hsa006201.23057739
51Glucagon signaling pathway_Homo sapiens_hsa049221.23016950
52Renal cell carcinoma_Homo sapiens_hsa052111.22228480
53Gap junction_Homo sapiens_hsa045401.20703250
54Adherens junction_Homo sapiens_hsa045201.20628578
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18245049
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16966141
57Fructose and mannose metabolism_Homo sapiens_hsa000511.16394029
58Taste transduction_Homo sapiens_hsa047421.15941470
59mTOR signaling pathway_Homo sapiens_hsa041501.15490317
60Long-term depression_Homo sapiens_hsa047301.14472160
61Dilated cardiomyopathy_Homo sapiens_hsa054141.13636940
62Prion diseases_Homo sapiens_hsa050201.13545638
63Small cell lung cancer_Homo sapiens_hsa052221.12896579
64Amoebiasis_Homo sapiens_hsa051461.11719585
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11565259
66Choline metabolism in cancer_Homo sapiens_hsa052311.10783506
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06854605
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05661676
69Oxidative phosphorylation_Homo sapiens_hsa001901.05157953
70Leukocyte transendothelial migration_Homo sapiens_hsa046701.05139000
71Thyroid cancer_Homo sapiens_hsa052161.03772657
72Serotonergic synapse_Homo sapiens_hsa047261.02422267
73cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02070170
74Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01896695
75Carbon metabolism_Homo sapiens_hsa012001.01381694
76Prolactin signaling pathway_Homo sapiens_hsa049170.99554627
77Butanoate metabolism_Homo sapiens_hsa006500.99056549
78Inositol phosphate metabolism_Homo sapiens_hsa005620.97448459
79Colorectal cancer_Homo sapiens_hsa052100.97161591
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97064118
81Prostate cancer_Homo sapiens_hsa052150.95288288
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.94142139
83Parkinsons disease_Homo sapiens_hsa050120.90535151
84MicroRNAs in cancer_Homo sapiens_hsa052060.90294548
85Lysine degradation_Homo sapiens_hsa003100.90029064
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88788740
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86399433
88Hepatitis C_Homo sapiens_hsa051600.86331506
89Type II diabetes mellitus_Homo sapiens_hsa049300.85136048
90Propanoate metabolism_Homo sapiens_hsa006400.83679002
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82466770
92Fatty acid degradation_Homo sapiens_hsa000710.82301326
93Lysosome_Homo sapiens_hsa041420.82187933
94Nitrogen metabolism_Homo sapiens_hsa009100.81909373
95* Insulin signaling pathway_Homo sapiens_hsa049100.81899843
96GnRH signaling pathway_Homo sapiens_hsa049120.81768001
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81675021
98B cell receptor signaling pathway_Homo sapiens_hsa046620.80821951
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.80541582
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.80171267
101cAMP signaling pathway_Homo sapiens_hsa040240.79789605
102Insulin resistance_Homo sapiens_hsa049310.78973558
103Hepatitis B_Homo sapiens_hsa051610.78707407
104Fatty acid metabolism_Homo sapiens_hsa012120.77724317
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.76994898
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75843143
107Rap1 signaling pathway_Homo sapiens_hsa040150.73936256
108Osteoclast differentiation_Homo sapiens_hsa043800.72406721
109Biosynthesis of amino acids_Homo sapiens_hsa012300.71848504
110Platelet activation_Homo sapiens_hsa046110.71299096
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69679054
112Alzheimers disease_Homo sapiens_hsa050100.69360355
113ErbB signaling pathway_Homo sapiens_hsa040120.69155566
114Shigellosis_Homo sapiens_hsa051310.69070610
115HIF-1 signaling pathway_Homo sapiens_hsa040660.68981774
116Glioma_Homo sapiens_hsa052140.68354030
117Salmonella infection_Homo sapiens_hsa051320.68200592
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67362734
119Pathways in cancer_Homo sapiens_hsa052000.67239531
120Apoptosis_Homo sapiens_hsa042100.67028409
121Estrogen signaling pathway_Homo sapiens_hsa049150.65909597
122Toxoplasmosis_Homo sapiens_hsa051450.65850462
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64643695
124Hippo signaling pathway_Homo sapiens_hsa043900.63188352
125Melanogenesis_Homo sapiens_hsa049160.62939672
126Galactose metabolism_Homo sapiens_hsa000520.62893013
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60213652
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59921051
129TNF signaling pathway_Homo sapiens_hsa046680.59049316
130Axon guidance_Homo sapiens_hsa043600.58738370
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56715505
132FoxO signaling pathway_Homo sapiens_hsa040680.56413939
133Viral carcinogenesis_Homo sapiens_hsa052030.55883071
134Tight junction_Homo sapiens_hsa045300.55595449
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53244404
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53057758
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.51662848
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51122621
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50540541
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49206258
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48755603
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48199265
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47126430
144Endocytosis_Homo sapiens_hsa041440.46776681
145Other glycan degradation_Homo sapiens_hsa005110.45780679
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44013768
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43672225
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43137766
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.41332342
150MAPK signaling pathway_Homo sapiens_hsa040100.41106561
151Thyroid hormone synthesis_Homo sapiens_hsa049180.40374463
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40344851
153Sulfur relay system_Homo sapiens_hsa041220.39084658
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.37800119
155Pancreatic secretion_Homo sapiens_hsa049720.37241002
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36670267
157Phagosome_Homo sapiens_hsa041450.35276610
158Sulfur metabolism_Homo sapiens_hsa009200.34085687
159AMPK signaling pathway_Homo sapiens_hsa041520.33472777
160Alcoholism_Homo sapiens_hsa050340.32808275
161Pentose phosphate pathway_Homo sapiens_hsa000300.31475385
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31282333

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