EXOC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.91606755
2presynaptic membrane organization (GO:0097090)5.90057529
3postsynaptic membrane organization (GO:0001941)5.71793573
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.45215041
5negative regulation of execution phase of apoptosis (GO:1900118)5.36683296
6short-term memory (GO:0007614)5.25091309
7positive regulation of gamma-delta T cell activation (GO:0046645)5.23071840
8axon ensheathment in central nervous system (GO:0032291)4.90104736
9central nervous system myelination (GO:0022010)4.90104736
10positive regulation of protein kinase C signaling (GO:0090037)4.85202826
11negative regulation of potassium ion transmembrane transport (GO:1901380)4.70171810
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.55462397
13toxin transport (GO:1901998)4.52636996
14negative regulation of erythrocyte differentiation (GO:0045647)4.40451110
15GMP metabolic process (GO:0046037)4.30174038
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.24160797
17negative regulation of cell killing (GO:0031342)4.24160797
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23119846
19response to peptidoglycan (GO:0032494)4.19478314
20regulation of B cell receptor signaling pathway (GO:0050855)4.12856469
21cellular extravasation (GO:0045123)4.12841010
22detection of molecule of bacterial origin (GO:0032490)4.08001952
23regulation of pigment cell differentiation (GO:0050932)3.99749629
24definitive hemopoiesis (GO:0060216)3.99430404
25melanin metabolic process (GO:0006582)3.94767552
26regulation of gamma-delta T cell activation (GO:0046643)3.88476459
27protein heterotetramerization (GO:0051290)3.82284429
28neuronal action potential propagation (GO:0019227)3.76391272
29regulation of gamma-delta T cell differentiation (GO:0045586)3.71584330
30facial nerve structural organization (GO:0021612)3.69275499
31negative regulation of interleukin-12 production (GO:0032695)3.67981813
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.66806185
33negative regulation of systemic arterial blood pressure (GO:0003085)3.65706599
34melanin biosynthetic process (GO:0042438)3.63848324
35response to interleukin-15 (GO:0070672)3.63544249
36limb bud formation (GO:0060174)3.61943439
37centriole replication (GO:0007099)3.61150803
38DNA methylation involved in gamete generation (GO:0043046)3.56582480
39endothelium development (GO:0003158)3.54696123
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54253458
41negative regulation of sodium ion transport (GO:0010766)3.51542216
42macrophage activation involved in immune response (GO:0002281)3.50929964
43axonemal dynein complex assembly (GO:0070286)3.46068396
44negative regulation of keratinocyte proliferation (GO:0010839)3.43203532
45developmental pigmentation (GO:0048066)3.42966023
46response to folic acid (GO:0051593)3.42929695
47neutrophil mediated immunity (GO:0002446)3.41367800
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.41234262
49negative regulation of transcription by competitive promoter binding (GO:0010944)3.39116452
50regulation of protein kinase A signaling (GO:0010738)3.36362268
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35520376
52regulation of tight junction assembly (GO:2000810)3.34699164
53neuron cell-cell adhesion (GO:0007158)3.34256982
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33575625
55regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.33499953
56negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.33342606
57centriole assembly (GO:0098534)3.31300876
58positive regulation by symbiont of host defense response (GO:0052509)3.30881905
59modulation by symbiont of host defense response (GO:0052031)3.30881905
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30881905
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30881905
62positive regulation by organism of defense response of other organism involved in symbiotic interact3.30881905
63modulation by symbiont of host immune response (GO:0052553)3.30881905
64estrogen biosynthetic process (GO:0006703)3.29143103
65membrane assembly (GO:0071709)3.28651625
66mesonephros development (GO:0001823)3.27534915
67necroptotic process (GO:0070266)3.26484466
68germinal center formation (GO:0002467)3.26063240
69eyelid development in camera-type eye (GO:0061029)3.22995839
70metanephric nephron tubule development (GO:0072234)3.22673429
71metanephric tubule development (GO:0072170)3.22673429
72lymphoid progenitor cell differentiation (GO:0002320)3.22672825
73cilium or flagellum-dependent cell motility (GO:0001539)3.22411130
74negative T cell selection (GO:0043383)3.20869416
75negative thymic T cell selection (GO:0045060)3.20680351
76cranial nerve structural organization (GO:0021604)3.20550662
77positive regulation of B cell differentiation (GO:0045579)3.20427330
78macrophage activation (GO:0042116)3.19937108
79embryonic process involved in female pregnancy (GO:0060136)3.19007257
80mesenchymal cell differentiation involved in renal system development (GO:2001012)3.17252545
81mesenchymal cell differentiation involved in kidney development (GO:0072161)3.17252545
82cell wall macromolecule metabolic process (GO:0044036)3.17231015
83cell wall macromolecule catabolic process (GO:0016998)3.17231015
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15722630
85negative regulation of T-helper cell differentiation (GO:0045623)3.15722630
86righting reflex (GO:0060013)3.14577071
87spliceosomal tri-snRNP complex assembly (GO:0000244)3.13422787
88protein K11-linked deubiquitination (GO:0035871)3.12900416
89antigen processing and presentation of endogenous antigen (GO:0019883)3.10704976
90spermatid nucleus differentiation (GO:0007289)3.06149438
91microglial cell activation (GO:0001774)3.05741178
92detection of external biotic stimulus (GO:0098581)3.05294196
93cellular response to ethanol (GO:0071361)3.05285017
94nuclear pore complex assembly (GO:0051292)3.04511238
95retina layer formation (GO:0010842)3.04084508
96T cell migration (GO:0072678)3.03357482
97regulation of interferon-beta biosynthetic process (GO:0045357)3.02797308
98cerebral cortex radially oriented cell migration (GO:0021799)3.02469068
99JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.02461051
100nephron epithelium development (GO:0072009)3.02212640
101negative regulation of T cell mediated immunity (GO:0002710)3.01260587
102GPI anchor biosynthetic process (GO:0006506)2.99738754
103positive regulation of interferon-beta production (GO:0032728)2.99400650
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99270743
105response to muramyl dipeptide (GO:0032495)2.98528071
106motile cilium assembly (GO:0044458)2.97569720
107cellular response to interleukin-15 (GO:0071350)2.95697325
108B cell receptor signaling pathway (GO:0050853)2.94935661
109positive regulation of granulocyte differentiation (GO:0030854)2.94560810
110multicellular organism reproduction (GO:0032504)2.93647148
111secondary metabolite biosynthetic process (GO:0044550)2.93434216
112metanephric epithelium development (GO:0072207)2.92282109
113cranial nerve morphogenesis (GO:0021602)2.91758134
114mannosylation (GO:0097502)2.90190002
115acrosome reaction (GO:0007340)2.90177299
116respiratory chain complex IV assembly (GO:0008535)2.89035310
117detection of other organism (GO:0098543)2.88924734
118eye photoreceptor cell differentiation (GO:0001754)2.88797563
119photoreceptor cell differentiation (GO:0046530)2.88797563
120leukocyte aggregation (GO:0070486)2.88263505
121epithelial cilium movement (GO:0003351)2.88256977
122metanephric nephron epithelium development (GO:0072243)2.87909559
123long-chain fatty acid biosynthetic process (GO:0042759)2.87625973
124phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.86881544
125negative regulation of lymphocyte mediated immunity (GO:0002707)2.86424412
126neutrophil activation involved in immune response (GO:0002283)2.85747435
127negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84483090
128myeloid leukocyte mediated immunity (GO:0002444)2.82918919
129positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.81746105
130fusion of sperm to egg plasma membrane (GO:0007342)2.81672319
131regulation of timing of cell differentiation (GO:0048505)2.80487212
132programmed necrotic cell death (GO:0097300)2.80469686
133positive regulation of interferon-alpha production (GO:0032727)2.78998799
134regulation of B cell differentiation (GO:0045577)2.77989731
135pattern specification involved in kidney development (GO:0061004)2.77481783
136lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77100542
137regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.76769670
138oligodendrocyte differentiation (GO:0048709)2.76499443
139regulation of fibroblast apoptotic process (GO:2000269)2.76470659
140necrotic cell death (GO:0070265)2.75948648
141positive regulation of synapse assembly (GO:0051965)2.75864315
142myeloid cell activation involved in immune response (GO:0002275)2.75326383
143regulation of chromatin binding (GO:0035561)2.75198838
144startle response (GO:0001964)2.74325658
145regulation of alpha-beta T cell proliferation (GO:0046640)2.72638595
146positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.71175754
147positive regulation of alpha-beta T cell proliferation (GO:0046641)2.71164643
148omega-hydroxylase P450 pathway (GO:0097267)2.70504758
149sympathetic nervous system development (GO:0048485)2.69542414
150regulation of interferon-alpha production (GO:0032647)2.68478111
151production of molecular mediator involved in inflammatory response (GO:0002532)2.68350623
152nuclear pore organization (GO:0006999)2.68118921
153GPI anchor metabolic process (GO:0006505)2.67496226
154acrosome assembly (GO:0001675)2.67073807
155interleukin-6-mediated signaling pathway (GO:0070102)2.66024993
156cytochrome complex assembly (GO:0017004)2.65805593
157regulation of protein kinase C signaling (GO:0090036)2.65352705
158regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.65338492
159negative regulation of B cell proliferation (GO:0030889)2.64708504
160positive regulation of calcium ion import (GO:0090280)2.63708352
161androgen biosynthetic process (GO:0006702)2.63199925
162DNA ligation (GO:0006266)2.62186977
163protein localization to cilium (GO:0061512)2.61536487
164detection of biotic stimulus (GO:0009595)2.61489030
165cilium movement (GO:0003341)2.61038263
166positive regulation of steroid hormone secretion (GO:2000833)2.60457975
167regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.60258727
168positive regulation of interleukin-2 production (GO:0032743)2.59902318
169positive regulation of cytokine biosynthetic process (GO:0042108)2.59238578
170GTP biosynthetic process (GO:0006183)2.58499728
171sphingoid metabolic process (GO:0046519)2.57782369
172positive T cell selection (GO:0043368)2.57592959
173organ growth (GO:0035265)2.55847975
174regulation of interferon-beta production (GO:0032648)2.55568007
175regulation of regulatory T cell differentiation (GO:0045589)2.55471482
176negative regulation of myoblast differentiation (GO:0045662)2.55444973
177neutrophil activation (GO:0042119)2.54737095
178regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54718095
179negative regulation of fibroblast apoptotic process (GO:2000270)2.53946266
180nonmotile primary cilium assembly (GO:0035058)2.53405269
181ribosomal small subunit biogenesis (GO:0042274)2.53290479
182positive regulation of natural killer cell differentiation (GO:0032825)2.52316637
183negative regulation of neurotransmitter secretion (GO:0046929)2.50497642
184response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48600076
185response to host immune response (GO:0052572)2.48600076
186tolerance induction (GO:0002507)2.46878521
187type I interferon signaling pathway (GO:0060337)2.46803222
188superoxide anion generation (GO:0042554)2.46615025
189protein localization to synapse (GO:0035418)2.45847070
190negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.44814501
191limb development (GO:0060173)2.44333693
192appendage development (GO:0048736)2.44333693
193negative regulation of myotube differentiation (GO:0010832)2.43592546
194cell differentiation involved in metanephros development (GO:0072202)2.43429908
195C-terminal protein lipidation (GO:0006501)2.43384438
196UV protection (GO:0009650)2.42154100
197cyclic nucleotide catabolic process (GO:0009214)2.41936225
198cornea development in camera-type eye (GO:0061303)2.41893944
199generation of neurons (GO:0048699)2.40446292
200positive regulation of cellular amine metabolic process (GO:0033240)2.39405724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50138279
2GATA1_22025678_ChIP-Seq_K562_Human5.27138693
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.44878945
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.11530200
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.62457135
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52398164
7GBX2_23144817_ChIP-Seq_PC3_Human3.12438006
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.01767544
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.93886295
10RUNX_20019798_ChIP-Seq_JUKART_Human2.82232191
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.80969328
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80389856
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.78703915
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76369498
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73963123
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72006489
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70206893
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68805011
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67175367
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.64918093
21TAF15_26573619_Chip-Seq_HEK293_Human2.64134022
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59287965
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54642674
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48178011
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47992203
26MYB_26560356_Chip-Seq_TH2_Human2.47964275
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.46631787
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.44675748
29JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31577509
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31554232
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31065494
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28784996
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28679371
34* NOTCH1_21737748_ChIP-Seq_TLL_Human2.28675592
35* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22678335
36BP1_19119308_ChIP-ChIP_Hs578T_Human2.20171338
37SUZ12_27294783_Chip-Seq_NPCs_Mouse2.18667612
38EZH2_27304074_Chip-Seq_ESCs_Mouse2.17342730
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15185454
40SCL_19346495_ChIP-Seq_HPC-7_Human2.10918735
41VDR_22108803_ChIP-Seq_LS180_Human2.09362929
42POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08607863
43MYB_26560356_Chip-Seq_TH1_Human2.04259802
44NFE2_27457419_Chip-Seq_LIVER_Mouse2.04112409
45EED_16625203_ChIP-ChIP_MESCs_Mouse2.01188489
46PCGF2_27294783_Chip-Seq_NPCs_Mouse2.00333066
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99891626
48AR_21572438_ChIP-Seq_LNCaP_Human1.90136554
49IGF1R_20145208_ChIP-Seq_DFB_Human1.90135183
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89725315
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87245094
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85839756
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.82075276
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.81948963
55RNF2_27304074_Chip-Seq_NSC_Mouse1.81941349
56SPI1_23547873_ChIP-Seq_NB4_Human1.79816910
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.79537074
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.77363338
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75465676
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75420918
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73187650
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72010072
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71341487
64P53_22387025_ChIP-Seq_ESCs_Mouse1.71110276
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.71097345
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70303150
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69660494
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69523399
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69292950
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.69083972
71ER_23166858_ChIP-Seq_MCF-7_Human1.68404225
72P300_18555785_Chip-Seq_ESCs_Mouse1.66584284
73P300_19829295_ChIP-Seq_ESCs_Human1.63122628
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.61032588
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60648813
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60648813
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60185742
78IRF1_19129219_ChIP-ChIP_H3396_Human1.60092213
79* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59951342
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.56921749
81RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56663687
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56593010
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54920688
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.54641757
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53125546
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.52841487
87TFEB_21752829_ChIP-Seq_HELA_Human1.51982491
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51176016
89MAF_26560356_Chip-Seq_TH1_Human1.48178993
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.48128160
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45481394
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.42694698
93MYC_22102868_ChIP-Seq_BL_Human1.41850162
94* TAL1_26923725_Chip-Seq_HPCs_Mouse1.40942275
95GATA3_27048872_Chip-Seq_THYMUS_Human1.40177224
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39552266
97PU_27001747_Chip-Seq_BMDM_Mouse1.38984788
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.37832398
99RNF2_27304074_Chip-Seq_ESCs_Mouse1.35746756
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.35724356
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.34801349
102VDR_24763502_ChIP-Seq_THP-1_Human1.34710603
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.33986030
104ZFX_18555785_Chip-Seq_ESCs_Mouse1.33261715
105PU1_27457419_Chip-Seq_LIVER_Mouse1.33029144
106SMAD1_18555785_Chip-Seq_ESCs_Mouse1.32797577
107SPI1_23127762_ChIP-Seq_K562_Human1.32521074
108GATA3_26560356_Chip-Seq_TH2_Human1.31985967
109* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31924029
110SMAD4_21799915_ChIP-Seq_A2780_Human1.31545576
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31482671
112KDM2B_26808549_Chip-Seq_REH_Human1.30823191
113FOXO3_23340844_ChIP-Seq_DLD1_Human1.29293554
114FUS_26573619_Chip-Seq_HEK293_Human1.27429502
115ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27180089
116VDR_24787735_ChIP-Seq_THP-1_Human1.26846422
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25947517
118CTCF_18555785_Chip-Seq_ESCs_Mouse1.25788021
119MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24871797
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24266153
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.23456607
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22985333
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22932555
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22571426
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22316849
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21755845
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.18297776
128POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17844211
129TP53_18474530_ChIP-ChIP_U2OS_Human1.16183853
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15725718
131SMAD_19615063_ChIP-ChIP_OVARY_Human1.14756116
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14596272
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13804220
134HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11380958
135* RUNX2_22187159_ChIP-Seq_PCA_Human1.11360439
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11233375
137GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10030947
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09256703
139GATA2_19941826_ChIP-Seq_K562_Human1.06614722
140GATA2_21666600_ChIP-Seq_HMVEC_Human1.06307565
141RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05852679
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05574198
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05018357
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04363554
145TCF4_23295773_ChIP-Seq_U87_Human1.04054489
146GATA1_19941826_ChIP-Seq_K562_Human1.03006752
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01986447
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01884792
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01882225
150UTX_26944678_Chip-Seq_JUKART_Human1.00736858
151TCF7_22412390_ChIP-Seq_EML_Mouse0.99870744
152STAT3_23295773_ChIP-Seq_U87_Human0.99773367
153* PRDM14_20953172_ChIP-Seq_ESCs_Human0.99464368
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98586835
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97197879
156KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96808927
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96001445
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96001445
159SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94488730
160VDR_21846776_ChIP-Seq_THP-1_Human0.90737839
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89549875
162* VDR_23849224_ChIP-Seq_CD4+_Human0.89477113
163STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86963322
164NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86773244
165GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85546894
166TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84269094
167RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84080907
168ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83540150
169SMRT_27268052_Chip-Seq_Bcells_Human0.81465166
170SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80230654
171SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80230654
172ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79211131
173NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79155400
174ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77707312
175BRD4_25478319_ChIP-Seq_HGPS_Human0.76951375
176PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76841784
177VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75528925
178MAF_26560356_Chip-Seq_TH2_Human0.74794609
179FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.74662873
180KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74536862
181CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74073319
182NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73624654
183NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73624654
184CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72283985
185CIITA_25753668_ChIP-Seq_RAJI_Human0.71999172
186GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71712647
187PADI4_21655091_ChIP-ChIP_MCF-7_Human0.69191331
188RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.69152682

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.68920394
2MP0001188_hyperpigmentation6.37263838
3MP0005409_darkened_coat_color5.99681578
4MP0009379_abnormal_foot_pigmentation4.74418144
5MP0004381_abnormal_hair_follicle4.15999480
6MP0000015_abnormal_ear_pigmentation3.62711447
7MP0005174_abnormal_tail_pigmentation3.51774294
8MP0003880_abnormal_central_pattern3.09633852
9MP0008057_abnormal_DNA_replication3.05351165
10MP0005451_abnormal_body_composition2.98727755
11MP0002166_altered_tumor_susceptibility2.89287670
12MP0001835_abnormal_antigen_presentation2.86637002
13MP0003763_abnormal_thymus_physiology2.74041590
14MP0006292_abnormal_olfactory_placode2.60015876
15MP0010234_abnormal_vibrissa_follicle2.41939899
16MP0002102_abnormal_ear_morphology2.30915380
17MP0001800_abnormal_humoral_immune2.26196443
18MP0003436_decreased_susceptibility_to2.25854030
19MP0000685_abnormal_immune_system2.22203727
20MP0002006_tumorigenesis2.21242285
21MP0005000_abnormal_immune_tolerance2.11551783
22MP0003724_increased_susceptibility_to2.11039217
23MP0001986_abnormal_taste_sensitivity2.10371857
24MP0000569_abnormal_digit_pigmentation2.09467495
25MP0002396_abnormal_hematopoietic_system2.00777410
26MP0005671_abnormal_response_to2.00388956
27MP0002723_abnormal_immune_serum1.99592529
28MP0001968_abnormal_touch/_nociception1.96021231
29MP0009785_altered_susceptibility_to1.93639400
30MP0004742_abnormal_vestibular_system1.93547454
31MP0002452_abnormal_antigen_presenting1.91419837
32MP0002419_abnormal_innate_immunity1.89889156
33MP0002420_abnormal_adaptive_immunity1.85181989
34MP0002398_abnormal_bone_marrow1.84157859
35MP0002095_abnormal_skin_pigmentation1.83697119
36MP0001819_abnormal_immune_cell1.83171813
37MP0005397_hematopoietic_system_phenotyp1.82017083
38MP0001545_abnormal_hematopoietic_system1.82017083
39MP0010352_gastrointestinal_tract_polyps1.80558059
40MP0005025_abnormal_response_to1.78239743
41MP0003300_gastrointestinal_ulcer1.76749867
42MP0003656_abnormal_erythrocyte_physiolo1.76293726
43MP0005171_absent_coat_pigmentation1.74183000
44MP0005387_immune_system_phenotype1.72607790
45MP0001790_abnormal_immune_system1.72607790
46MP0003221_abnormal_cardiomyocyte_apopto1.70532613
47MP0004808_abnormal_hematopoietic_stem1.65866840
48MP0000716_abnormal_immune_system1.63753508
49MP0000689_abnormal_spleen_morphology1.56509481
50MP0000566_synostosis1.54853744
51MP0005410_abnormal_fertilization1.54848130
52MP0008260_abnormal_autophagy1.52856612
53MP0004142_abnormal_muscle_tone1.49840859
54MP0002405_respiratory_system_inflammati1.49024414
55MP0005310_abnormal_salivary_gland1.48884336
56MP0002638_abnormal_pupillary_reflex1.47312814
57MP0002277_abnormal_respiratory_mucosa1.45696035
58MP0002177_abnormal_outer_ear1.45409816
59MP0001845_abnormal_inflammatory_respons1.45051392
60MP0001486_abnormal_startle_reflex1.42883618
61MP0002722_abnormal_immune_system1.42630959
62MP0002429_abnormal_blood_cell1.34288588
63MP0004947_skin_inflammation1.33718814
64MP0002876_abnormal_thyroid_physiology1.33238269
65MP0003172_abnormal_lysosome_physiology1.32703033
66MP0000703_abnormal_thymus_morphology1.29531073
67MP0009046_muscle_twitch1.29189291
68MP0006082_CNS_inflammation1.27966383
69MP0004233_abnormal_muscle_weight1.27670893
70MP0005464_abnormal_platelet_physiology1.27526721
71MP0005075_abnormal_melanosome_morpholog1.26344818
72MP0003045_fibrosis1.24235077
73MP0002272_abnormal_nervous_system1.23866743
74MP0002138_abnormal_hepatobiliary_system1.23721836
75MP0000920_abnormal_myelination1.23388544
76MP0002877_abnormal_melanocyte_morpholog1.21385712
77MP0003191_abnormal_cellular_cholesterol1.17842718
78MP0002837_dystrophic_cardiac_calcinosis1.17763670
79MP0008469_abnormal_protein_level1.16228118
80MP0002067_abnormal_sensory_capabilities1.14336966
81MP0000049_abnormal_middle_ear1.13000197
82MP0001851_eye_inflammation1.12212312
83MP0000631_abnormal_neuroendocrine_gland1.11557950
84MP0010307_abnormal_tumor_latency1.11387657
85MP0010155_abnormal_intestine_physiology1.11144910
86MP0009333_abnormal_splenocyte_physiolog1.09034672
87MP0009745_abnormal_behavioral_response1.08914738
88MP0000026_abnormal_inner_ear1.08064015
89MP0002332_abnormal_exercise_endurance1.07146693
90MP0005164_abnormal_response_to1.06362345
91MP0003828_pulmonary_edema1.06194624
92MP0004185_abnormal_adipocyte_glucose1.06065948
93MP0002734_abnormal_mechanical_nocicepti1.05589685
94MP0008877_abnormal_DNA_methylation1.05128275
95MP0001533_abnormal_skeleton_physiology1.04131971
96MP0005551_abnormal_eye_electrophysiolog1.04015892
97MP0006276_abnormal_autonomic_nervous1.03803656
98MP0004130_abnormal_muscle_cell1.01074132
99MP0002751_abnormal_autonomic_nervous1.00460768
100MP0005423_abnormal_somatic_nervous1.00319769
101MP0001905_abnormal_dopamine_level0.99673581
102MP0009764_decreased_sensitivity_to0.99627434
103MP0002735_abnormal_chemical_nociception0.98981047
104MP0001970_abnormal_pain_threshold0.98764772
105MP0005595_abnormal_vascular_smooth0.97511891
106MP0005166_decreased_susceptibility_to0.97432448
107MP0002998_abnormal_bone_remodeling0.96564378
108MP0003938_abnormal_ear_development0.96536065
109MP0003075_altered_response_to0.95888818
110MP0000778_abnormal_nervous_system0.95562004
111MP0009250_abnormal_appendicular_skeleto0.93285689
112MP0000762_abnormal_tongue_morphology0.92956153
113MP0001963_abnormal_hearing_physiology0.92462374
114MP0003315_abnormal_perineum_morphology0.90344005
115MP0002249_abnormal_larynx_morphology0.90209049
116MP0002009_preneoplasia0.89941984
117MP0000372_irregular_coat_pigmentation0.87791952
118MP0005379_endocrine/exocrine_gland_phen0.87276323
119MP0002736_abnormal_nociception_after0.86951964
120MP0000613_abnormal_salivary_gland0.83798600
121MP0003941_abnormal_skin_development0.82728702
122MP0005645_abnormal_hypothalamus_physiol0.82018986
123MP0001919_abnormal_reproductive_system0.81880772
124MP0000579_abnormal_nail_morphology0.81313708
125MP0000013_abnormal_adipose_tissue0.81162697
126MP0002064_seizures0.81129643
127MP0003635_abnormal_synaptic_transmissio0.81082989
128MP0003690_abnormal_glial_cell0.80964307
129MP0002557_abnormal_social/conspecific_i0.80633677
130MP0002693_abnormal_pancreas_physiology0.79114571
131MP0009278_abnormal_bone_marrow0.78711051
132MP0002752_abnormal_somatic_nervous0.78285698
133MP0009115_abnormal_fat_cell0.77935153
134MP0008961_abnormal_basal_metabolism0.77788210
135MP0003866_abnormal_defecation0.77784221
136MP0003453_abnormal_keratinocyte_physiol0.77423450
137MP0003448_altered_tumor_morphology0.76673729
138MP0001191_abnormal_skin_condition0.75711824
139MP0000371_diluted_coat_color0.75649671
140MP0002019_abnormal_tumor_incidence0.75155920
141MP0005646_abnormal_pituitary_gland0.75147906
142MP0003698_abnormal_male_reproductive0.75117161
143MP0003950_abnormal_plasma_membrane0.74864365
144MP0000733_abnormal_muscle_development0.74279927
145MP0004883_abnormal_blood_vessel0.74001505
146MP0005076_abnormal_cell_differentiation0.73951027
147MP0003091_abnormal_cell_migration0.73926040
148MP0004484_altered_response_of0.73095658
149MP0000681_abnormal_thyroid_gland0.71480708
150MP0004510_myositis0.71451395
151MP0002139_abnormal_hepatobiliary_system0.70432758
152MP0005375_adipose_tissue_phenotype0.70350297
153MP0004270_analgesia0.70249599
154MP0002572_abnormal_emotion/affect_behav0.70198302
155MP0005666_abnormal_adipose_tissue0.68242443
156MP0002163_abnormal_gland_morphology0.67871923
157MP0008569_lethality_at_weaning0.66711819
158MP0000609_abnormal_liver_physiology0.66546350
159MP0008058_abnormal_DNA_repair0.66282919
160MP0003303_peritoneal_inflammation0.66199981
161MP0003787_abnormal_imprinting0.66134227
162MP0003646_muscle_fatigue0.66061209
163MP0001853_heart_inflammation0.64864572
164MP0002229_neurodegeneration0.64435516
165MP0001664_abnormal_digestion0.64291239
166MP0005388_respiratory_system_phenotype0.63430311
167MP0002133_abnormal_respiratory_system0.63430311
168MP0006072_abnormal_retinal_apoptosis0.63371196
169MP0001502_abnormal_circadian_rhythm0.63166118
170MP0001177_atelectasis0.63125598
171MP0003718_maternal_effect0.62173029
172MP0002184_abnormal_innervation0.61098378
173MP0000465_gastrointestinal_hemorrhage0.60565277
174MP0002148_abnormal_hypersensitivity_rea0.60186976
175MP0005195_abnormal_posterior_eye0.59060592
176MP0002882_abnormal_neuron_morphology0.58325123
177MP0001340_abnormal_eyelid_morphology0.58152741
178MP0003937_abnormal_limbs/digits/tail_de0.56735397
179MP0005253_abnormal_eye_physiology0.56593206
180MP0002160_abnormal_reproductive_system0.56566782
181MP0002132_abnormal_respiratory_system0.56303035
182MP0003011_delayed_dark_adaptation0.56046300
183MP0005165_increased_susceptibility_to0.55718785
184MP0008995_early_reproductive_senescence0.55486106
185MP0001346_abnormal_lacrimal_gland0.53953169
186MP0001485_abnormal_pinna_reflex0.53316637
187MP0001186_pigmentation_phenotype0.52581521

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of secondary sexual hair (HP:0009888)5.17640889
2Abnormality of the axillary hair (HP:0100134)5.17640889
3Thoracolumbar scoliosis (HP:0002944)5.03989371
4Sex reversal (HP:0012245)4.76804797
5Abnormal sex determination (HP:0012244)4.76804797
6Absent/shortened dynein arms (HP:0200106)4.59771809
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.59771809
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.53376108
9Eczematoid dermatitis (HP:0000976)3.94478559
10T lymphocytopenia (HP:0005403)3.91539476
11Facial hemangioma (HP:0000329)3.71438294
12Abnormal respiratory epithelium morphology (HP:0012253)3.62022778
13Abnormal respiratory motile cilium morphology (HP:0005938)3.62022778
14Recurrent bacterial skin infections (HP:0005406)3.55924160
15Abnormality of the lumbar spine (HP:0100712)3.55057151
16Gastrointestinal infarctions (HP:0005244)3.54505950
17Obstructive sleep apnea (HP:0002870)3.54186051
18Recurrent fungal infections (HP:0002841)3.48713005
19Abnormality of T cell number (HP:0011839)3.46549317
20Abnormal ciliary motility (HP:0012262)3.44152272
21Abnormal respiratory motile cilium physiology (HP:0012261)3.38212830
22Abnormality of macular pigmentation (HP:0008002)3.34997738
23Fatigue (HP:0012378)3.32809869
24Type I transferrin isoform profile (HP:0003642)3.31434318
25Sensory axonal neuropathy (HP:0003390)3.23486688
26Recurrent abscess formation (HP:0002722)3.23263727
27Protruding tongue (HP:0010808)3.22841730
28Capillary hemangiomas (HP:0005306)3.20714854
29Orchitis (HP:0100796)3.15143248
30Attenuation of retinal blood vessels (HP:0007843)3.13910912
31Reduced antithrombin III activity (HP:0001976)3.10808702
32Myositis (HP:0100614)3.05684836
33Optic nerve hypoplasia (HP:0000609)3.04597826
34Retrobulbar optic neuritis (HP:0100654)3.03464402
35Optic neuritis (HP:0100653)3.03464402
36Thoracic kyphosis (HP:0002942)3.00719005
37Acute myeloid leukemia (HP:0004808)2.96957168
38Pustule (HP:0200039)2.94543037
39Abnormality of T cells (HP:0002843)2.92141700
40Self-mutilation (HP:0000742)2.91327614
41Optic disc pallor (HP:0000543)2.91283844
42Recurrent viral infections (HP:0004429)2.90894698
43Abnormality of macrophages (HP:0004311)2.84563516
44Increased CSF protein (HP:0002922)2.80454691
45Abnormality of T cell physiology (HP:0011840)2.79899530
46Chest pain (HP:0100749)2.78075916
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.75795719
48Arterial thrombosis (HP:0004420)2.75683821
49Dyschromatopsia (HP:0007641)2.75181311
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.75109538
51Thyroid-stimulating hormone excess (HP:0002925)2.74807242
52Mediastinal lymphadenopathy (HP:0100721)2.74746139
53Autoimmune hemolytic anemia (HP:0001890)2.72731697
54Subacute progressive viral hepatitis (HP:0006572)2.69757043
55Parakeratosis (HP:0001036)2.69011838
563-Methylglutaconic aciduria (HP:0003535)2.68567279
57Recurrent skin infections (HP:0001581)2.62847097
58Hematochezia (HP:0002573)2.62763787
59Syringomyelia (HP:0003396)2.62388066
60Spinal cord lesions (HP:0100561)2.62388066
61Cheilitis (HP:0100825)2.60204685
62Spontaneous hematomas (HP:0007420)2.59631288
63Elevated erythrocyte sedimentation rate (HP:0003565)2.58645684
64Curly hair (HP:0002212)2.58309094
65Nonprogressive disorder (HP:0003680)2.57798368
66Long eyelashes (HP:0000527)2.56516945
67Central scotoma (HP:0000603)2.56189277
68Split foot (HP:0001839)2.56094037
69Recurrent cutaneous fungal infections (HP:0011370)2.55831617
70Chronic mucocutaneous candidiasis (HP:0002728)2.55831617
71Hypothermia (HP:0002045)2.52847365
72Bile duct proliferation (HP:0001408)2.52326205
73Abnormal biliary tract physiology (HP:0012439)2.52326205
74Septo-optic dysplasia (HP:0100842)2.51593858
75Sleep apnea (HP:0010535)2.50225474
76Gingival bleeding (HP:0000225)2.49219746
77Gonadal dysgenesis (HP:0000133)2.43288691
78Vasculitis (HP:0002633)2.42069682
79Abnormality of the intrinsic pathway (HP:0010989)2.41913513
80Chronic diarrhea (HP:0002028)2.41084824
81Gaze-evoked nystagmus (HP:0000640)2.40825476
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40601425
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.38575508
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38438723
85Peritonitis (HP:0002586)2.37543995
86Cone-rod dystrophy (HP:0000548)2.37069231
87Retinal dysplasia (HP:0007973)2.33981338
88Rhinitis (HP:0012384)2.32667513
89Leukocytosis (HP:0001974)2.32263014
90Nephronophthisis (HP:0000090)2.32204355
91Abnormality of magnesium homeostasis (HP:0004921)2.28649759
92Alacrima (HP:0000522)2.28293335
93Pulmonary infiltrates (HP:0002113)2.27703406
94Acute hepatic failure (HP:0006554)2.26399668
95Papillary thyroid carcinoma (HP:0002895)2.26184917
96Focal motor seizures (HP:0011153)2.25090633
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.23320085
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22898900
99Abnormal protein N-linked glycosylation (HP:0012347)2.22898900
100Abnormal protein glycosylation (HP:0012346)2.22898900
101Abnormal glycosylation (HP:0012345)2.22898900
102Submucous cleft hard palate (HP:0000176)2.21759502
103Medial flaring of the eyebrow (HP:0010747)2.21140970
104Amaurosis fugax (HP:0100576)2.21116978
105Abnormality of the thoracic spine (HP:0100711)2.20683584
106Keratoconjunctivitis sicca (HP:0001097)2.20333241
107Thrombocytosis (HP:0001894)2.20268107
108Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19223167
109True hermaphroditism (HP:0010459)2.18715691
110Abnormality of the septum pellucidum (HP:0007375)2.18373498
111Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17940184
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17826902
113Absent septum pellucidum (HP:0001331)2.17724215
114Inflammation of the large intestine (HP:0002037)2.15717320
115White forelock (HP:0002211)2.15592275
116Decreased lacrimation (HP:0000633)2.15580768
117Short tibia (HP:0005736)2.14924194
118Ocular albinism (HP:0001107)2.14244048
119Alopecia of scalp (HP:0002293)2.10352517
120Patchy hypopigmentation of hair (HP:0011365)2.08181844
121Albinism (HP:0001022)2.05540959
122Hypomagnesemia (HP:0002917)2.03884293
123Keratoconjunctivitis (HP:0001096)2.03679925
124Myocardial infarction (HP:0001658)2.03133305
125Male pseudohermaphroditism (HP:0000037)2.03129289
126Increased hepatocellular lipid droplets (HP:0006565)2.01504046
127Absent speech (HP:0001344)2.01171814
128Esotropia (HP:0000565)2.00606883
129Hepatocellular necrosis (HP:0001404)2.00461186
130Macroorchidism (HP:0000053)1.99525711
131Congenital sensorineural hearing impairment (HP:0008527)1.99296076
132Iris hypopigmentation (HP:0007730)1.96391075
133Renal Fanconi syndrome (HP:0001994)1.95442619
134Cutaneous melanoma (HP:0012056)1.93458093
135Recurrent gram-negative bacterial infections (HP:0005420)1.91398857
136Gastrointestinal inflammation (HP:0004386)1.91240824
137IgM deficiency (HP:0002850)1.91206327
138Abnormality of the columella (HP:0009929)1.91187431
139Meningitis (HP:0001287)1.90565884
140Abnormality of the renal medulla (HP:0100957)1.90094803
141Low anterior hairline (HP:0000294)1.89904132
142Absent eyebrow (HP:0002223)1.89403191
143Hemoptysis (HP:0002105)1.89304576
144Stomatitis (HP:0010280)1.88769291
145Micronodular cirrhosis (HP:0001413)1.88317057
146Microvesicular hepatic steatosis (HP:0001414)1.87805674
147Reticulocytopenia (HP:0001896)1.87122854
148Neoplasm of the tracheobronchial system (HP:0100552)1.86131249
149Prolonged bleeding time (HP:0003010)1.86010175
150Chronic obstructive pulmonary disease (HP:0006510)1.84314732
151Obstructive lung disease (HP:0006536)1.84314732
152Concave nail (HP:0001598)1.84070385
153Gingivitis (HP:0000230)1.83733406
154Viral hepatitis (HP:0006562)1.83449660
155Broad-based gait (HP:0002136)1.83388084
156Bradycardia (HP:0001662)1.83272800
157Severe visual impairment (HP:0001141)1.82194308
158Anorexia (HP:0002039)1.82034595
159Slow saccadic eye movements (HP:0000514)1.81848580
160Tubulointerstitial nephritis (HP:0001970)1.81798973
161Acute necrotizing encephalopathy (HP:0006965)1.81585253
162Urticaria (HP:0001025)1.81363236
163Truncal obesity (HP:0001956)1.81277697
164Epistaxis (HP:0000421)1.81244309
165Thyroid carcinoma (HP:0002890)1.80239767
166Mitochondrial inheritance (HP:0001427)1.79287680
167Dry hair (HP:0011359)1.78722208
168Gait imbalance (HP:0002141)1.78679947
169Macular degeneration (HP:0000608)1.78623060
170Coxa valga (HP:0002673)1.77431900
171Osteomyelitis (HP:0002754)1.75888455
172Anhidrosis (HP:0000970)1.75524143
173Overlapping toe (HP:0001845)1.75037148
174Episodic fever (HP:0001954)1.73814114
175Rhabdomyosarcoma (HP:0002859)1.73584133
176Laryngomalacia (HP:0001601)1.73539291
177Congenital primary aphakia (HP:0007707)1.73382674
178Polycythemia (HP:0001901)1.72855661
179Cellulitis (HP:0100658)1.72535575
180Lymphopenia (HP:0001888)1.72446609
181Nasolacrimal duct obstruction (HP:0000579)1.72061977
182Decreased central vision (HP:0007663)1.72012698
183Granulocytopenia (HP:0001913)1.71581570
184Abnormality of the lacrimal duct (HP:0011481)1.71356036
185Aplasia/hypoplasia of the uterus (HP:0008684)1.71076814
186Vaginal atresia (HP:0000148)1.71026830
187Duplicated collecting system (HP:0000081)1.69223810
188Stage 5 chronic kidney disease (HP:0003774)1.66631144
189Febrile seizures (HP:0002373)1.65755795
190Aplasia/Hypoplasia of the lens (HP:0008063)1.65033450
191Abnormality of dental color (HP:0011073)1.64082365
192Agammaglobulinemia (HP:0004432)1.63153907
193Genital tract atresia (HP:0001827)1.62017346
194Progressive macrocephaly (HP:0004481)1.61498603
195Abnormal hair whorl (HP:0010721)1.61456834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.61893464
2MKNK24.16488769
3TNIK3.07111555
4TLK12.95367452
5DAPK22.80782838
6FRK2.53996305
7AKT32.42039184
8MKNK12.32834347
9MAP4K12.23219982
10TYK22.19764798
11TAOK32.17768032
12STK162.05426196
13MAP3K22.00364622
14EIF2AK31.99638233
15MUSK1.98029890
16FES1.95985891
17PHKG21.94292510
18PHKG11.94292510
19MAP3K131.94178744
20JAK31.91407706
21ZAP701.86938628
22CDK61.83436077
23YES11.75921381
24BLK1.75876238
25STK391.75823189
26MAP2K31.72202456
27PRPF4B1.66620013
28IRAK41.64215775
29CLK11.62327359
30EIF2AK21.59922984
31TRPM71.55650070
32PKN11.53057920
33CDK121.52278436
34IRAK11.52145976
35LATS11.50890370
36JAK11.50469160
37MAP3K31.40777524
38IRAK31.40148593
39BMPR1B1.38843221
40JAK21.35365412
41SRPK11.33347849
42FGFR31.30391228
43STK101.30327796
44NLK1.29558664
45KSR21.29346172
46MARK31.27880723
47OXSR11.23748232
48STK241.21740697
49ACVR1B1.21428057
50IKBKB1.20651767
51MAP3K61.18708780
52TBK11.18674461
53PIM11.18326877
54GRK11.17863628
55ADRBK21.17563070
56VRK11.14565721
57GRK71.07838261
58CDK191.07354723
59IRAK21.06276305
60RAF11.05383257
61SYK1.05304240
62CAMKK20.99147431
63GRK60.97836372
64MAP2K70.97257281
65PRKD20.93928003
66ITK0.93557993
67MST40.91045340
68FER0.88706653
69INSRR0.85569340
70TAF10.82168566
71MAP3K10.81547007
72KSR10.80566723
73NEK60.80401140
74MATK0.77543361
75MAPK130.77533689
76PBK0.76478993
77STK40.76463684
78RPS6KL10.74991991
79RPS6KC10.74991991
80CAMK2B0.73861751
81MELK0.73263665
82NUAK10.73217918
83MAP3K40.72429130
84BTK0.71979911
85MAPK150.70770554
86DYRK20.70437643
87CDK30.69690188
88MAP3K140.68366015
89TEC0.68012634
90TXK0.67843703
91RPS6KA60.66613596
92NME10.66124947
93ZAK0.65015565
94BMPR20.64850809
95SMG10.64688856
96NME20.63539578
97UHMK10.62187413
98PIK3CG0.60732221
99HIPK20.60707025
100TGFBR20.60569664
101PRKCE0.58449203
102MAPK110.58000485
103PRKG10.57652460
104ERBB30.56947091
105ERN10.56768484
106TNK20.56020526
107CAMK2D0.55635800
108CAMK10.54832295
109CAMK2A0.54782336
110SGK2230.53390894
111SGK4940.53390894
112NTRK30.53166294
113TIE10.52941081
114SGK30.52352051
115BRAF0.51121247
116MAP2K40.50224878
117DAPK10.50182137
118BCR0.50040191
119SGK20.49929699
120KIT0.49545143
121PDGFRB0.47163460
122STK30.47001582
123SIK30.45763607
124MAPKAPK50.45584376
125CHUK0.44612433
126STK38L0.44219298
127PRKAA20.44157274
128OBSCN0.43817308
129PDK10.43335981
130PAK10.41713220
131IKBKE0.41338125
132MAP2K60.40446280
133MAP3K120.39392123
134DYRK1A0.37748911
135MAP3K90.37504493
136MAP3K50.37115258
137SIK20.36851659
138DYRK30.36196112
139LCK0.35657382
140FGR0.35112370
141RPS6KA50.34481456
142MAP3K100.33806475
143DAPK30.33413086
144CSK0.32722697
145MYLK0.32364776
146PINK10.31148521
147WNK40.30655311
148RIPK40.30352718
149EPHB10.30204862
150WNK10.29726519
151CAMK2G0.27809877
152LYN0.27756386
153PRKACA0.27253549
154ADRBK10.26557501
155CSNK1G10.25063373
156ROCK20.25016979
157EPHA30.24943086
158PRKG20.24576006
159STK110.23700350
160HCK0.23275464
161BRD40.22938144

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.40024466
2Ribosome_Homo sapiens_hsa030102.85436050
3Phototransduction_Homo sapiens_hsa047442.83803325
4Fanconi anemia pathway_Homo sapiens_hsa034602.53159057
5Sphingolipid metabolism_Homo sapiens_hsa006002.36412511
6Oxidative phosphorylation_Homo sapiens_hsa001902.31692725
7Leishmaniasis_Homo sapiens_hsa051402.28455457
8Measles_Homo sapiens_hsa051622.27745237
9Osteoclast differentiation_Homo sapiens_hsa043802.22221362
10B cell receptor signaling pathway_Homo sapiens_hsa046622.20695687
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.10152596
12T cell receptor signaling pathway_Homo sapiens_hsa046602.06600331
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.03090627
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02795655
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02098453
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00240851
17Acute myeloid leukemia_Homo sapiens_hsa052211.97697962
18Selenocompound metabolism_Homo sapiens_hsa004501.91925518
19Nicotine addiction_Homo sapiens_hsa050331.91087917
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.88798512
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85397653
22Homologous recombination_Homo sapiens_hsa034401.81725002
23Other glycan degradation_Homo sapiens_hsa005111.80311097
24Tuberculosis_Homo sapiens_hsa051521.77481125
25Fatty acid elongation_Homo sapiens_hsa000621.75132327
26Ether lipid metabolism_Homo sapiens_hsa005651.68562233
27Long-term depression_Homo sapiens_hsa047301.68096560
28Dorso-ventral axis formation_Homo sapiens_hsa043201.67682432
29Prolactin signaling pathway_Homo sapiens_hsa049171.60933024
30Influenza A_Homo sapiens_hsa051641.58543208
31Legionellosis_Homo sapiens_hsa051341.57560333
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57208458
33TNF signaling pathway_Homo sapiens_hsa046681.55817658
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53713454
35Arachidonic acid metabolism_Homo sapiens_hsa005901.52953493
36Toxoplasmosis_Homo sapiens_hsa051451.50571393
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49228483
38Hepatitis B_Homo sapiens_hsa051611.49012770
39Non-small cell lung cancer_Homo sapiens_hsa052231.46704250
40Autoimmune thyroid disease_Homo sapiens_hsa053201.44934122
41Parkinsons disease_Homo sapiens_hsa050121.44184825
42Herpes simplex infection_Homo sapiens_hsa051681.43732327
43Chronic myeloid leukemia_Homo sapiens_hsa052201.43562882
44Type I diabetes mellitus_Homo sapiens_hsa049401.41521823
45Serotonergic synapse_Homo sapiens_hsa047261.40311712
46Basal transcription factors_Homo sapiens_hsa030221.38338380
47Morphine addiction_Homo sapiens_hsa050321.37816771
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35282383
49Huntingtons disease_Homo sapiens_hsa050161.32862488
50FoxO signaling pathway_Homo sapiens_hsa040681.31415465
51Alzheimers disease_Homo sapiens_hsa050101.29895126
52RNA polymerase_Homo sapiens_hsa030201.29546618
53Axon guidance_Homo sapiens_hsa043601.26851781
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26526879
55Taste transduction_Homo sapiens_hsa047421.25664126
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21440042
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21203571
58Pancreatic cancer_Homo sapiens_hsa052121.19792672
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19069286
60Chemokine signaling pathway_Homo sapiens_hsa040621.17596552
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16355619
62Thyroid cancer_Homo sapiens_hsa052161.15592074
63Staphylococcus aureus infection_Homo sapiens_hsa051501.13362912
64Glutamatergic synapse_Homo sapiens_hsa047241.10642157
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06747499
66Endometrial cancer_Homo sapiens_hsa052131.06674798
67Calcium signaling pathway_Homo sapiens_hsa040201.06397399
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06187567
69Type II diabetes mellitus_Homo sapiens_hsa049301.05203061
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04571747
71Malaria_Homo sapiens_hsa051441.00587767
72Apoptosis_Homo sapiens_hsa042101.00515215
73Cardiac muscle contraction_Homo sapiens_hsa042600.99282754
74Non-homologous end-joining_Homo sapiens_hsa034500.98300230
75mTOR signaling pathway_Homo sapiens_hsa041500.97872373
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97715534
77Platelet activation_Homo sapiens_hsa046110.97221282
78Hepatitis C_Homo sapiens_hsa051600.96627825
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.95227355
80Renal cell carcinoma_Homo sapiens_hsa052110.95062970
81Antigen processing and presentation_Homo sapiens_hsa046120.94334718
82Linoleic acid metabolism_Homo sapiens_hsa005910.94254580
83Bladder cancer_Homo sapiens_hsa052190.94018423
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92454894
85Asthma_Homo sapiens_hsa053100.92408748
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.91369671
87Allograft rejection_Homo sapiens_hsa053300.90932554
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90612914
89Melanogenesis_Homo sapiens_hsa049160.90505001
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89390859
91Viral carcinogenesis_Homo sapiens_hsa052030.84231665
92Purine metabolism_Homo sapiens_hsa002300.83803589
93Insulin resistance_Homo sapiens_hsa049310.82243960
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82002666
95Hematopoietic cell lineage_Homo sapiens_hsa046400.81904275
96Colorectal cancer_Homo sapiens_hsa052100.81659566
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81628748
98Inositol phosphate metabolism_Homo sapiens_hsa005620.79558328
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79303521
100Graft-versus-host disease_Homo sapiens_hsa053320.76805924
101Shigellosis_Homo sapiens_hsa051310.76004247
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75908323
103Systemic lupus erythematosus_Homo sapiens_hsa053220.75874553
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75827471
105Rheumatoid arthritis_Homo sapiens_hsa053230.75404495
106Viral myocarditis_Homo sapiens_hsa054160.74874696
107Pertussis_Homo sapiens_hsa051330.74722813
108HIF-1 signaling pathway_Homo sapiens_hsa040660.74653972
109African trypanosomiasis_Homo sapiens_hsa051430.74496138
110VEGF signaling pathway_Homo sapiens_hsa043700.73918347
111Wnt signaling pathway_Homo sapiens_hsa043100.73776982
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73773650
113Glioma_Homo sapiens_hsa052140.73546098
114Salmonella infection_Homo sapiens_hsa051320.72708348
115Regulation of autophagy_Homo sapiens_hsa041400.71710598
116Circadian entrainment_Homo sapiens_hsa047130.69521710
117Choline metabolism in cancer_Homo sapiens_hsa052310.69125939
118Renin secretion_Homo sapiens_hsa049240.68394517
119Melanoma_Homo sapiens_hsa052180.67592323
120GABAergic synapse_Homo sapiens_hsa047270.67433201
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67271390
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66823901
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65846001
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.65613735
125Salivary secretion_Homo sapiens_hsa049700.65513877
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65102001
127Phagosome_Homo sapiens_hsa041450.64600636
128Alcoholism_Homo sapiens_hsa050340.62278400
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60891627
130Ras signaling pathway_Homo sapiens_hsa040140.60617880
131Epstein-Barr virus infection_Homo sapiens_hsa051690.59716522
132MicroRNAs in cancer_Homo sapiens_hsa052060.58672207
133cAMP signaling pathway_Homo sapiens_hsa040240.57096989
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.55438445
135GnRH signaling pathway_Homo sapiens_hsa049120.54956429
136Cholinergic synapse_Homo sapiens_hsa047250.53175112
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52931606
138Lysosome_Homo sapiens_hsa041420.52656759
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.52569231
140Circadian rhythm_Homo sapiens_hsa047100.52209114
141Basal cell carcinoma_Homo sapiens_hsa052170.52087511
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.51885067
143p53 signaling pathway_Homo sapiens_hsa041150.51757501
144Small cell lung cancer_Homo sapiens_hsa052220.51345350
145Olfactory transduction_Homo sapiens_hsa047400.50605162
146HTLV-I infection_Homo sapiens_hsa051660.48095346
147Histidine metabolism_Homo sapiens_hsa003400.46160297
148Collecting duct acid secretion_Homo sapiens_hsa049660.46076759
149Steroid biosynthesis_Homo sapiens_hsa001000.45807919
150NF-kappa B signaling pathway_Homo sapiens_hsa040640.44625427
151Ovarian steroidogenesis_Homo sapiens_hsa049130.44269776
152Vibrio cholerae infection_Homo sapiens_hsa051100.43391712
153N-Glycan biosynthesis_Homo sapiens_hsa005100.42724004
154Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42464624
155Amphetamine addiction_Homo sapiens_hsa050310.42156961
156ErbB signaling pathway_Homo sapiens_hsa040120.41972199
157Primary immunodeficiency_Homo sapiens_hsa053400.41676747
158Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41309049
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41113641
160MAPK signaling pathway_Homo sapiens_hsa040100.38904140
161Vitamin digestion and absorption_Homo sapiens_hsa049770.37712070
162Steroid hormone biosynthesis_Homo sapiens_hsa001400.36117548
163Pyrimidine metabolism_Homo sapiens_hsa002400.35130857
164Hedgehog signaling pathway_Homo sapiens_hsa043400.35091837
165Sphingolipid signaling pathway_Homo sapiens_hsa040710.34749039
166Prostate cancer_Homo sapiens_hsa052150.34574093
167Cocaine addiction_Homo sapiens_hsa050300.34250126
168Insulin secretion_Homo sapiens_hsa049110.33900140
169Gastric acid secretion_Homo sapiens_hsa049710.33049937
170ABC transporters_Homo sapiens_hsa020100.30588849
171Metabolic pathways_Homo sapiens_hsa011000.30380060

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