EXOG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)4.05431468
2peptidyl-arginine N-methylation (GO:0035246)3.98898061
3peptidyl-arginine methylation (GO:0018216)3.98898061
4DNA double-strand break processing (GO:0000729)3.83851172
5replication fork processing (GO:0031297)3.82077517
6platelet dense granule organization (GO:0060155)3.69910323
7protein-cofactor linkage (GO:0018065)3.68184359
8protein complex biogenesis (GO:0070271)3.65995351
9neuron cell-cell adhesion (GO:0007158)3.59487647
10histone arginine methylation (GO:0034969)3.57495736
11chaperone-mediated protein transport (GO:0072321)3.57469492
12negative regulation of microtubule polymerization (GO:0031115)3.52773539
13mitochondrial respiratory chain complex assembly (GO:0033108)3.49509872
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47697504
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.47697504
16NADH dehydrogenase complex assembly (GO:0010257)3.47697504
17proteasome assembly (GO:0043248)3.38501705
18cullin deneddylation (GO:0010388)3.35016183
19nonmotile primary cilium assembly (GO:0035058)3.31815214
20respiratory chain complex IV assembly (GO:0008535)3.29105934
21spliceosomal snRNP assembly (GO:0000387)3.25136712
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.25088355
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.25088355
24protein localization to cilium (GO:0061512)3.25026085
25postreplication repair (GO:0006301)3.20926472
26recombinational repair (GO:0000725)3.20766235
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20158232
28synapsis (GO:0007129)3.16551939
29protein localization to synapse (GO:0035418)3.14854703
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13801321
31DNA damage response, detection of DNA damage (GO:0042769)3.13718112
32response to pheromone (GO:0019236)3.12819380
33double-strand break repair via homologous recombination (GO:0000724)3.10701774
34synaptic vesicle exocytosis (GO:0016079)3.07127055
35reciprocal DNA recombination (GO:0035825)3.05164846
36reciprocal meiotic recombination (GO:0007131)3.05164846
37resolution of meiotic recombination intermediates (GO:0000712)3.04662046
38establishment of integrated proviral latency (GO:0075713)3.04384578
39maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00428802
40cilium morphogenesis (GO:0060271)3.00058212
41chromatin remodeling at centromere (GO:0031055)2.99735090
42behavioral response to nicotine (GO:0035095)2.97934549
43transcription elongation from RNA polymerase III promoter (GO:0006385)2.97406167
44termination of RNA polymerase III transcription (GO:0006386)2.97406167
45protein deneddylation (GO:0000338)2.96066171
46cellular ketone body metabolic process (GO:0046950)2.94649631
47detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.93679020
48negative regulation of DNA-dependent DNA replication (GO:2000104)2.93145518
49synaptic vesicle maturation (GO:0016188)2.91830663
50transmission of nerve impulse (GO:0019226)2.91053350
51spliceosomal complex assembly (GO:0000245)2.89839916
52substantia nigra development (GO:0021762)2.89359502
53ketone body metabolic process (GO:1902224)2.88031903
54positive regulation of mitochondrial fission (GO:0090141)2.85252953
55CENP-A containing nucleosome assembly (GO:0034080)2.84939691
56intraciliary transport (GO:0042073)2.84660844
57cytochrome complex assembly (GO:0017004)2.84239338
58viral mRNA export from host cell nucleus (GO:0046784)2.83854597
59ribonucleoprotein complex disassembly (GO:0032988)2.83648405
60maturation of SSU-rRNA (GO:0030490)2.82584451
61somatic hypermutation of immunoglobulin genes (GO:0016446)2.81659052
62somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81659052
63translesion synthesis (GO:0019985)2.81634609
64DNA unwinding involved in DNA replication (GO:0006268)2.80603770
65ATP synthesis coupled proton transport (GO:0015986)2.78092711
66energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78092711
67dopamine transport (GO:0015872)2.77236409
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74375666
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.73370250
70protein prenylation (GO:0018342)2.72675590
71prenylation (GO:0097354)2.72675590
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.72584865
73anterograde synaptic vesicle transport (GO:0048490)2.71444083
74regulation of telomere maintenance (GO:0032204)2.71034525
75L-methionine salvage (GO:0071267)2.70732240
76L-methionine biosynthetic process (GO:0071265)2.70732240
77amino acid salvage (GO:0043102)2.70732240
78regulation of sarcomere organization (GO:0060297)2.70655768
79pseudouridine synthesis (GO:0001522)2.67689795
80DNA-dependent DNA replication (GO:0006261)2.66585119
81regulation of DNA endoreduplication (GO:0032875)2.65716001
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65672185
83cell migration in hindbrain (GO:0021535)2.65669213
84regulation of mitochondrial translation (GO:0070129)2.65579847
85signal peptide processing (GO:0006465)2.65144689
86peptidyl-arginine modification (GO:0018195)2.62191377
87presynaptic membrane organization (GO:0097090)2.61990483
88viral transcription (GO:0019083)2.60972587
89establishment of mitochondrion localization (GO:0051654)2.60957830
90respiratory electron transport chain (GO:0022904)2.59485949
91regulation of synaptic vesicle exocytosis (GO:2000300)2.59148359
92neuron recognition (GO:0008038)2.59079441
93cilium organization (GO:0044782)2.57526190
94electron transport chain (GO:0022900)2.56987220
95L-fucose catabolic process (GO:0042355)2.56893780
96fucose catabolic process (GO:0019317)2.56893780
97L-fucose metabolic process (GO:0042354)2.56893780
98DNA strand elongation involved in DNA replication (GO:0006271)2.56327684
99neuronal action potential propagation (GO:0019227)2.56319882
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55906799
101protein neddylation (GO:0045116)2.55525204
102regulation of action potential (GO:0098900)2.55324584
103negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55317987
104negative regulation of translation, ncRNA-mediated (GO:0040033)2.55317987
105regulation of translation, ncRNA-mediated (GO:0045974)2.55317987
106C4-dicarboxylate transport (GO:0015740)2.55186185
107negative regulation of telomere maintenance (GO:0032205)2.55076394
108DNA catabolic process, exonucleolytic (GO:0000738)2.54853490
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54645672
110cilium assembly (GO:0042384)2.54565744
111DNA ligation (GO:0006266)2.54119758
112central nervous system myelination (GO:0022010)2.53984605
113axon ensheathment in central nervous system (GO:0032291)2.53984605
1147-methylguanosine mRNA capping (GO:0006370)2.53429930
115negative regulation of axon extension (GO:0030517)2.53370563
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53318584
117regulation of mitotic spindle checkpoint (GO:1903504)2.53318584
118pyrimidine nucleobase catabolic process (GO:0006208)2.53053152
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.52926113
120formation of translation preinitiation complex (GO:0001731)2.51908568
1217-methylguanosine RNA capping (GO:0009452)2.51822720
122RNA capping (GO:0036260)2.51822720
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50954223
124regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50467641
125preassembly of GPI anchor in ER membrane (GO:0016254)2.50356401
126ribosomal small subunit assembly (GO:0000028)2.50261364
127mannosylation (GO:0097502)2.48256851
128translational termination (GO:0006415)2.47669738
129regulation of hexokinase activity (GO:1903299)2.47632609
130regulation of glucokinase activity (GO:0033131)2.47632609
131tRNA processing (GO:0008033)2.47550112
132telomere maintenance via telomerase (GO:0007004)2.47511851
133anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.47162115
134ribosomal large subunit biogenesis (GO:0042273)2.46402948
135epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46315038
136negative regulation of DNA recombination (GO:0045910)2.46002384
137DNA deamination (GO:0045006)2.45863445
138positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44670547
139pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44434802
140exploration behavior (GO:0035640)2.43245609
141negative regulation of ligase activity (GO:0051352)2.41901902
142negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.41901902
143protein-DNA complex disassembly (GO:0032986)2.41011790
144nucleosome disassembly (GO:0006337)2.41011790
145presynaptic membrane assembly (GO:0097105)2.40965228
146cellular protein complex disassembly (GO:0043624)2.40874917
147guanosine-containing compound biosynthetic process (GO:1901070)2.39440989
148macromolecular complex disassembly (GO:0032984)2.38721409
149regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.38548793
150neuronal ion channel clustering (GO:0045161)2.38132088
151DNA strand elongation (GO:0022616)2.38025340
152negative regulation of axonogenesis (GO:0050771)2.37689354
153cotranslational protein targeting to membrane (GO:0006613)2.36944103
154axonal fasciculation (GO:0007413)2.36417515
155protein complex disassembly (GO:0043241)2.35155775
156positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.33490935
157telomere maintenance via semi-conservative replication (GO:0032201)2.32865114
158nucleobase biosynthetic process (GO:0046112)2.31811830
159regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31750292
160GMP metabolic process (GO:0046037)2.31193905
161metaphase plate congression (GO:0051310)2.31159864
162translational elongation (GO:0006414)2.30171119
163gamma-aminobutyric acid signaling pathway (GO:0007214)2.29767547
164SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.29133000
165establishment of viral latency (GO:0019043)2.28743083
166histone H2A acetylation (GO:0043968)2.28477339
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.27290876
168mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.27039054
169protein targeting to ER (GO:0045047)2.26612904
170regulation of centriole replication (GO:0046599)2.26514850
171translational initiation (GO:0006413)2.26351728
172purine nucleobase biosynthetic process (GO:0009113)2.25867798
173vocalization behavior (GO:0071625)2.24721173
174exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24560984
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.24260841
176microtubule polymerization or depolymerization (GO:0031109)2.23966371
177ribosomal small subunit biogenesis (GO:0042274)2.23192234
178histone mRNA metabolic process (GO:0008334)2.23003004
179intra-S DNA damage checkpoint (GO:0031573)2.22784158
180negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.22352998
181organelle disassembly (GO:1903008)2.22266026
182layer formation in cerebral cortex (GO:0021819)2.22000910
183transcription elongation from RNA polymerase I promoter (GO:0006362)2.21130776
184establishment of protein localization to endoplasmic reticulum (GO:0072599)2.19527283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.69928119
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42406178
3E2F7_22180533_ChIP-Seq_HELA_Human3.33241658
4EZH2_22144423_ChIP-Seq_EOC_Human3.26943614
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10193613
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.02988930
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.00625024
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.84478045
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.81020860
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80529366
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.74041369
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64589305
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.64323189
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.63828462
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57511085
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55393035
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54069972
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49182478
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.48443234
20VDR_22108803_ChIP-Seq_LS180_Human2.46750431
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45500696
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43400535
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41500802
24XRN2_22483619_ChIP-Seq_HELA_Human2.31992453
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29165062
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23642006
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22936597
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20714455
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.13703386
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09308038
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08715175
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04704215
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01923205
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99094568
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.98590340
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97437864
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95343291
38P300_19829295_ChIP-Seq_ESCs_Human1.82440785
39TTF2_22483619_ChIP-Seq_HELA_Human1.78999376
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78140391
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77546444
42VDR_23849224_ChIP-Seq_CD4+_Human1.76010951
43DCP1A_22483619_ChIP-Seq_HELA_Human1.75345845
44FOXP3_21729870_ChIP-Seq_TREG_Human1.69586838
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66106752
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58303142
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57059626
48GBX2_23144817_ChIP-Seq_PC3_Human1.55187209
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51434507
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51163484
51REST_21632747_ChIP-Seq_MESCs_Mouse1.50878870
52SMAD4_21799915_ChIP-Seq_A2780_Human1.50247662
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49706547
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49641305
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48763837
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48302941
57GABP_19822575_ChIP-Seq_HepG2_Human1.47089231
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45374811
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.44966091
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43786565
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43666214
62CBP_20019798_ChIP-Seq_JUKART_Human1.43666214
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42636357
64IRF1_19129219_ChIP-ChIP_H3396_Human1.41683125
65ER_23166858_ChIP-Seq_MCF-7_Human1.41657305
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41369254
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.41196656
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.40045950
69CIITA_25753668_ChIP-Seq_RAJI_Human1.38798867
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35997168
71TP53_22573176_ChIP-Seq_HFKS_Human1.34692028
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33706000
73ELK1_19687146_ChIP-ChIP_HELA_Human1.33487331
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33384445
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.33005544
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32941185
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.32724700
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32435891
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30612967
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29615553
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27546806
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27218190
83STAT3_23295773_ChIP-Seq_U87_Human1.26676586
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26097509
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.26008291
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25595610
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24824466
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23929763
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.23918589
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23332887
91TCF4_23295773_ChIP-Seq_U87_Human1.20002412
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.19814246
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19273888
94FUS_26573619_Chip-Seq_HEK293_Human1.18400953
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18064253
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17824363
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17767263
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17230133
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17162961
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16886902
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16469034
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15391573
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15391573
104BCAT_22108803_ChIP-Seq_LS180_Human1.15386842
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14911668
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14554529
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14360416
108TCF4_22108803_ChIP-Seq_LS180_Human1.13555901
109EWS_26573619_Chip-Seq_HEK293_Human1.12144750
110RNF2_27304074_Chip-Seq_NSC_Mouse1.11765599
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.11662794
112AR_25329375_ChIP-Seq_VCAP_Human1.11609777
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.11376252
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11215919
115P53_22387025_ChIP-Seq_ESCs_Mouse1.11172113
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.11005479
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.10612569
118MYC_18940864_ChIP-ChIP_HL60_Human1.10323785
119TAF15_26573619_Chip-Seq_HEK293_Human1.10244287
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09688996
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09366216
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09012173
123EED_16625203_ChIP-ChIP_MESCs_Mouse1.07165062
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.06752182
125SRF_21415370_ChIP-Seq_HL-1_Mouse1.06526424
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06460705
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.06298440
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06143819
129PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05269481
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.03823815
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03767560
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03704705
133KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03307804
134RUNX2_22187159_ChIP-Seq_PCA_Human1.03099643
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02959153
136FLI1_21867929_ChIP-Seq_TH2_Mouse1.02947797
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01936578
138JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00698587
139HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00591853
140* SOX2_19829295_ChIP-Seq_ESCs_Human1.00248759
141* NANOG_19829295_ChIP-Seq_ESCs_Human1.00248759
142P300_18555785_Chip-Seq_ESCs_Mouse1.00190340
143KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99836130
144EZH2_27294783_Chip-Seq_ESCs_Mouse0.99027789
145SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98883476
146EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97182045
147RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97182045
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94754836
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94699855
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94564116
151CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94381234
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.94348354
153SOX9_26525672_Chip-Seq_HEART_Mouse0.93375392
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93208052
155ZNF274_21170338_ChIP-Seq_K562_Hela0.91580073
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91543807
157E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89842615
158TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89134575
159* IGF1R_20145208_ChIP-Seq_DFB_Human0.88251464
160TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86344628
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85525917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.06303594
2MP0004859_abnormal_synaptic_plasticity3.41639856
3MP0004270_analgesia2.86401565
4MP0003635_abnormal_synaptic_transmissio2.55160647
5MP0000372_irregular_coat_pigmentation2.49874375
6MP0000569_abnormal_digit_pigmentation2.48967982
7MP0001529_abnormal_vocalization2.48501692
8MP0000778_abnormal_nervous_system2.42201184
9MP0002837_dystrophic_cardiac_calcinosis2.32677037
10MP0005423_abnormal_somatic_nervous2.30561424
11MP0003787_abnormal_imprinting2.14505780
12MP0002064_seizures2.09687570
13MP0002063_abnormal_learning/memory/cond2.06940073
14MP0001486_abnormal_startle_reflex2.04970756
15MP0009745_abnormal_behavioral_response2.03815605
16MP0002734_abnormal_mechanical_nocicepti2.03564707
17MP0009046_muscle_twitch1.96880273
18MP0006276_abnormal_autonomic_nervous1.96666334
19MP0005551_abnormal_eye_electrophysiolog1.96458157
20MP0005253_abnormal_eye_physiology1.95612943
21MP0001968_abnormal_touch/_nociception1.94924784
22MP0003122_maternal_imprinting1.93695587
23MP0003121_genomic_imprinting1.90815208
24MP0001905_abnormal_dopamine_level1.90303148
25MP0003195_calcinosis1.84478411
26MP0002184_abnormal_innervation1.83796757
27MP0002572_abnormal_emotion/affect_behav1.81473256
28MP0002735_abnormal_chemical_nociception1.81177201
29MP0008789_abnormal_olfactory_epithelium1.80462550
30MP0002272_abnormal_nervous_system1.78843006
31MP0008877_abnormal_DNA_methylation1.78804540
32MP0005499_abnormal_olfactory_system1.76049329
33MP0005394_taste/olfaction_phenotype1.76049329
34MP0004142_abnormal_muscle_tone1.68066466
35MP0003786_premature_aging1.65492669
36MP0003123_paternal_imprinting1.64948880
37MP0001485_abnormal_pinna_reflex1.63403730
38MP0003693_abnormal_embryo_hatching1.63032392
39MP0002736_abnormal_nociception_after1.61546629
40MP0002638_abnormal_pupillary_reflex1.58601839
41MP0000955_abnormal_spinal_cord1.58482132
42MP0008932_abnormal_embryonic_tissue1.53729088
43MP0004957_abnormal_blastocyst_morpholog1.53276011
44MP0003077_abnormal_cell_cycle1.51551403
45MP0002102_abnormal_ear_morphology1.51262758
46MP0002067_abnormal_sensory_capabilities1.48962716
47MP0000631_abnormal_neuroendocrine_gland1.45957828
48MP0002882_abnormal_neuron_morphology1.45578035
49MP0002234_abnormal_pharynx_morphology1.45460725
50MP0003136_yellow_coat_color1.44885618
51MP0002095_abnormal_skin_pigmentation1.44863092
52MP0003111_abnormal_nucleus_morphology1.44635708
53MP0003938_abnormal_ear_development1.44365807
54MP0002751_abnormal_autonomic_nervous1.43152960
55MP0002733_abnormal_thermal_nociception1.42995423
56MP0010094_abnormal_chromosome_stability1.42772529
57MP0004811_abnormal_neuron_physiology1.42353667
58MP0002557_abnormal_social/conspecific_i1.40866450
59MP0004215_abnormal_myocardial_fiber1.39108888
60MP0008057_abnormal_DNA_replication1.38431617
61MP0005645_abnormal_hypothalamus_physiol1.37521155
62MP0004133_heterotaxia1.36527128
63MP0001440_abnormal_grooming_behavior1.33358757
64MP0004924_abnormal_behavior1.32170588
65MP0005386_behavior/neurological_phenoty1.32170588
66MP0002152_abnormal_brain_morphology1.30625977
67MP0004885_abnormal_endolymph1.30046499
68MP0001970_abnormal_pain_threshold1.29501929
69MP0003861_abnormal_nervous_system1.28503233
70MP0005174_abnormal_tail_pigmentation1.27987400
71MP0008995_early_reproductive_senescence1.26810259
72MP0010030_abnormal_orbit_morphology1.26162095
73MP0001764_abnormal_homeostasis1.24443374
74MP0004742_abnormal_vestibular_system1.23527528
75MP0000427_abnormal_hair_cycle1.23317053
76MP0003718_maternal_effect1.22646445
77MP0004145_abnormal_muscle_electrophysio1.22059825
78MP0006292_abnormal_olfactory_placode1.20836964
79MP0005075_abnormal_melanosome_morpholog1.20426407
80MP0002163_abnormal_gland_morphology1.20383237
81MP0000015_abnormal_ear_pigmentation1.19692999
82MP0010386_abnormal_urinary_bladder1.18395363
83MP0008058_abnormal_DNA_repair1.17499809
84MP0000749_muscle_degeneration1.16077544
85MP0002653_abnormal_ependyma_morphology1.15581394
86MP0002066_abnormal_motor_capabilities/c1.14781897
87MP0002752_abnormal_somatic_nervous1.13948888
88MP0002822_catalepsy1.09231314
89MP0000920_abnormal_myelination1.08795388
90MP0002938_white_spotting1.08320588
91MP0001963_abnormal_hearing_physiology1.07827564
92MP0009379_abnormal_foot_pigmentation1.07088202
93MP0003890_abnormal_embryonic-extraembry1.06005246
94MP0008569_lethality_at_weaning1.03779795
95MP0005248_abnormal_Harderian_gland1.02715186
96MP0006035_abnormal_mitochondrial_morpho1.02310574
97MP0001984_abnormal_olfaction1.01622077
98MP0000026_abnormal_inner_ear0.99606389
99MP0000647_abnormal_sebaceous_gland0.99019749
100MP0001501_abnormal_sleep_pattern0.98888756
101MP0000516_abnormal_urinary_system0.98811772
102MP0005367_renal/urinary_system_phenotyp0.98811772
103MP0006072_abnormal_retinal_apoptosis0.98454622
104MP0005391_vision/eye_phenotype0.96986045
105MP0009697_abnormal_copulation0.96907061
106MP0002090_abnormal_vision0.96879330
107MP0003315_abnormal_perineum_morphology0.96271501
108MP0006036_abnormal_mitochondrial_physio0.94187152
109MP0005646_abnormal_pituitary_gland0.92841044
110MP0003646_muscle_fatigue0.92164963
111MP0002160_abnormal_reproductive_system0.90686128
112MP0001293_anophthalmia0.89732376
113MP0005379_endocrine/exocrine_gland_phen0.89618351
114MP0008007_abnormal_cellular_replicative0.89260514
115MP0003950_abnormal_plasma_membrane0.89198884
116MP0008872_abnormal_physiological_respon0.88696079
117MP0003186_abnormal_redox_activity0.88356841
118MP0002229_neurodegeneration0.88050802
119MP0005195_abnormal_posterior_eye0.87444498
120MP0002396_abnormal_hematopoietic_system0.86945913
121MP0000049_abnormal_middle_ear0.86302148
122MP0002254_reproductive_system_inflammat0.85517831
123MP0005389_reproductive_system_phenotype0.85285818
124MP0000537_abnormal_urethra_morphology0.85046115
125MP0000350_abnormal_cell_proliferation0.84769127
126MP0001730_embryonic_growth_arrest0.84719429
127MP0004084_abnormal_cardiac_muscle0.84269120
128MP0004147_increased_porphyrin_level0.84159104
129MP0000462_abnormal_digestive_system0.84071529
130MP0001324_abnormal_eye_pigmentation0.82438333
131MP0003119_abnormal_digestive_system0.82383982
132MP0001929_abnormal_gametogenesis0.79990534
133MP0002081_perinatal_lethality0.78862638
134MP0003937_abnormal_limbs/digits/tail_de0.78694065
135MP0005409_darkened_coat_color0.77836359
136MP0003634_abnormal_glial_cell0.76391166
137MP0001986_abnormal_taste_sensitivity0.76031079
138MP0005187_abnormal_penis_morphology0.74722731
139MP0005171_absent_coat_pigmentation0.73386415
140MP0003632_abnormal_nervous_system0.72736959
141MP0003385_abnormal_body_wall0.71906775
142MP0002085_abnormal_embryonic_tissue0.71252926
143MP0003698_abnormal_male_reproductive0.70637884
144MP0003137_abnormal_impulse_conducting0.70415463
145MP0001697_abnormal_embryo_size0.69363021
146MP0001727_abnormal_embryo_implantation0.68383765
147MP0010770_preweaning_lethality0.68311000
148MP0002082_postnatal_lethality0.68311000
149MP0002069_abnormal_eating/drinking_beha0.66370664

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)3.76390964
2Pancreatic fibrosis (HP:0100732)3.71807407
3Abnormality of midbrain morphology (HP:0002418)3.55073381
4Molar tooth sign on MRI (HP:0002419)3.55073381
5Pancreatic cysts (HP:0001737)3.52718537
6Myokymia (HP:0002411)3.40305177
7Acute encephalopathy (HP:0006846)3.37409457
8Medial flaring of the eyebrow (HP:0010747)3.30647892
9Focal motor seizures (HP:0011153)3.22578424
10Sensory axonal neuropathy (HP:0003390)3.18898341
11True hermaphroditism (HP:0010459)3.18304067
12Atonic seizures (HP:0010819)3.06853280
13Increased hepatocellular lipid droplets (HP:0006565)3.05526495
14Hepatocellular necrosis (HP:0001404)3.02925196
15Volvulus (HP:0002580)2.94313389
16Epileptic encephalopathy (HP:0200134)2.89316266
17Nephronophthisis (HP:0000090)2.86223551
18Mitochondrial inheritance (HP:0001427)2.81124764
19Degeneration of the lateral corticospinal tracts (HP:0002314)2.78286796
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.78286796
21Gait imbalance (HP:0002141)2.69672089
22Congenital primary aphakia (HP:0007707)2.68928625
23Renal cortical cysts (HP:0000803)2.65361286
24Abnormality of glycolysis (HP:0004366)2.63600284
25Increased serum pyruvate (HP:0003542)2.63600284
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.62552242
27Abnormality of the corticospinal tract (HP:0002492)2.60809183
28Overriding aorta (HP:0002623)2.60279991
29Neuroendocrine neoplasm (HP:0100634)2.58342932
30Abnormality of the labia minora (HP:0012880)2.57617500
31Abnormality of the renal cortex (HP:0011035)2.56771222
32Nephrogenic diabetes insipidus (HP:0009806)2.54485343
33Pheochromocytoma (HP:0002666)2.52780285
34Abnormality of the renal medulla (HP:0100957)2.46601463
35Cerebral edema (HP:0002181)2.46498893
36Lipid accumulation in hepatocytes (HP:0006561)2.45994172
37Congenital stationary night blindness (HP:0007642)2.39448098
38Focal seizures (HP:0007359)2.38146941
39Intestinal atresia (HP:0011100)2.37666000
40Ankle clonus (HP:0011448)2.36443486
41Increased CSF lactate (HP:0002490)2.33382906
42Spastic gait (HP:0002064)2.33189981
43Short tibia (HP:0005736)2.32275704
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.29298291
45Gaze-evoked nystagmus (HP:0000640)2.28852193
46Tubulointerstitial nephritis (HP:0001970)2.28706982
47Chronic hepatic failure (HP:0100626)2.28499106
48Abnormality of chromosome stability (HP:0003220)2.28236926
49Abnormal hair whorl (HP:0010721)2.27000163
50Postnatal microcephaly (HP:0005484)2.26615140
51Genital tract atresia (HP:0001827)2.26536818
52Lissencephaly (HP:0001339)2.23996347
53Abnormality of alanine metabolism (HP:0010916)2.22407140
54Hyperalaninemia (HP:0003348)2.22407140
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22407140
56Postaxial foot polydactyly (HP:0001830)2.21255247
57Meckel diverticulum (HP:0002245)2.20729970
58Type 2 muscle fiber atrophy (HP:0003554)2.20250224
593-Methylglutaconic aciduria (HP:0003535)2.20245941
60Visual hallucinations (HP:0002367)2.19767107
61Acute necrotizing encephalopathy (HP:0006965)2.18672462
62Abnormality of the septum pellucidum (HP:0007375)2.18495355
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17426335
64CNS hypomyelination (HP:0003429)2.16725335
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15693751
66Abnormality of the ileum (HP:0001549)2.14478384
67Emotional lability (HP:0000712)2.12233273
68Type II lissencephaly (HP:0007260)2.11300325
69Aplasia/Hypoplasia of the patella (HP:0006498)2.10991784
70Optic disc pallor (HP:0000543)2.09454408
71Chromsome breakage (HP:0040012)2.07731909
72Aplastic anemia (HP:0001915)2.06860478
73Methylmalonic acidemia (HP:0002912)2.06825425
74Patellar aplasia (HP:0006443)2.06594814
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.05223416
76Hemiparesis (HP:0001269)2.04493507
77Neoplasm of the adrenal cortex (HP:0100641)2.03614759
78Sclerocornea (HP:0000647)2.03554619
79Insomnia (HP:0100785)2.02458960
80Renal Fanconi syndrome (HP:0001994)2.02172759
81Pendular nystagmus (HP:0012043)2.02040524
82Akinesia (HP:0002304)2.02038961
83Drooling (HP:0002307)2.01735422
84Astigmatism (HP:0000483)2.00476984
85Hypoplasia of the brainstem (HP:0002365)1.99617496
86Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99617496
87Partial agenesis of the corpus callosum (HP:0001338)1.99524895
88Hypoplastic pelvis (HP:0008839)1.99236141
89Decreased central vision (HP:0007663)1.98709350
90Abnormality of DNA repair (HP:0003254)1.97955925
91Poor coordination (HP:0002370)1.97681820
92Febrile seizures (HP:0002373)1.97207743
93Renal duplication (HP:0000075)1.97111050
94Lactic acidosis (HP:0003128)1.96629596
95Postaxial hand polydactyly (HP:0001162)1.96253517
96Vaginal atresia (HP:0000148)1.96243570
97Generalized hypotonia (HP:0001290)1.94731433
98Increased serum lactate (HP:0002151)1.94577860
99Abnormality of macular pigmentation (HP:0008002)1.94229911
100Oral leukoplakia (HP:0002745)1.93575287
101Broad-based gait (HP:0002136)1.93414714
102Narrow forehead (HP:0000341)1.92792271
103Oligodactyly (hands) (HP:0001180)1.92780232
104Absent septum pellucidum (HP:0001331)1.92486890
105Cystic liver disease (HP:0006706)1.90935798
106Glioma (HP:0009733)1.90607587
107Attenuation of retinal blood vessels (HP:0007843)1.90127607
108Aqueductal stenosis (HP:0002410)1.88943311
109Megalencephaly (HP:0001355)1.88137977
110Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87592927
111Progressive inability to walk (HP:0002505)1.87086970
112Limb dystonia (HP:0002451)1.86730826
113Absence seizures (HP:0002121)1.86529174
114Hepatic necrosis (HP:0002605)1.86326011
115Bile duct proliferation (HP:0001408)1.85901122
116Abnormal biliary tract physiology (HP:0012439)1.85901122
117Ridged nail (HP:0001807)1.84581355
118Abnormal mitochondria in muscle tissue (HP:0008316)1.84376199
119Pachygyria (HP:0001302)1.83841104
120Medulloblastoma (HP:0002885)1.83805080
121Small hand (HP:0200055)1.83534404
122Anencephaly (HP:0002323)1.83255940
123Rough bone trabeculation (HP:0100670)1.83122343
124Inability to walk (HP:0002540)1.82782604
125Progressive macrocephaly (HP:0004481)1.82100682
126Protruding tongue (HP:0010808)1.80407604
127Leukodystrophy (HP:0002415)1.80089733
128Dyschromatopsia (HP:0007641)1.80071994
129Abnormality of the astrocytes (HP:0100707)1.80005646
130Astrocytoma (HP:0009592)1.80005646
131Septo-optic dysplasia (HP:0100842)1.78763386
132Optic nerve hypoplasia (HP:0000609)1.77774324
133Left ventricular hypertrophy (HP:0001712)1.77536970
134Termporal pattern (HP:0011008)1.77481885
135Insidious onset (HP:0003587)1.77481885
136Excessive salivation (HP:0003781)1.77020330
137Hip dysplasia (HP:0001385)1.77016663
138Abnormal rod and cone electroretinograms (HP:0008323)1.76795524
139Sloping forehead (HP:0000340)1.75302519
140Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74219782
141Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74219782
142Progressive cerebellar ataxia (HP:0002073)1.74186870
143Neonatal respiratory distress (HP:0002643)1.73466447
144Increased corneal curvature (HP:0100692)1.72913672
145Keratoconus (HP:0000563)1.72913672
146Bifid tongue (HP:0010297)1.72501277
147Aganglionic megacolon (HP:0002251)1.71791451
148Preaxial hand polydactyly (HP:0001177)1.71766285
149Gastrointestinal atresia (HP:0002589)1.71664622
150Exertional dyspnea (HP:0002875)1.71457122
151Hypothermia (HP:0002045)1.70286260
152Retinal dysplasia (HP:0007973)1.69944889
153Patellar dislocation (HP:0002999)1.68969304
154Urinary urgency (HP:0000012)1.68885631
155Male pseudohermaphroditism (HP:0000037)1.68137341
156Hyperventilation (HP:0002883)1.67614093
157Congenital hepatic fibrosis (HP:0002612)1.67221760
158Increased intramyocellular lipid droplets (HP:0012240)1.67046534
159Respiratory failure (HP:0002878)1.66837051
160Poor suck (HP:0002033)1.66826239
161Colon cancer (HP:0003003)1.66152806
162Peripheral hypomyelination (HP:0007182)1.64018388
163Premature graying of hair (HP:0002216)1.63654426
164Rimmed vacuoles (HP:0003805)1.63527203
165Posterior embryotoxon (HP:0000627)1.63513174
166Cerebellar hypoplasia (HP:0001321)1.62853419
167Supernumerary spleens (HP:0009799)1.62472279
168Abnormal lung lobation (HP:0002101)1.62018776
169Hyperacusis (HP:0010780)1.61947354
170Neoplasm of the peripheral nervous system (HP:0100007)1.60477420
171Heterochromia iridis (HP:0001100)1.60364696
172Dialeptic seizures (HP:0011146)1.60262384
173Esotropia (HP:0000565)1.60204449
174Elfin facies (HP:0004428)1.59215282
175Amyotrophic lateral sclerosis (HP:0007354)1.58232392
176Flat cornea (HP:0007720)1.57206568
177Nephroblastoma (Wilms tumor) (HP:0002667)1.56893401
178Fetal akinesia sequence (HP:0001989)1.56434833
179Vertebral arch anomaly (HP:0008438)1.56404357
180Abnormality of the preputium (HP:0100587)1.55950888
181Pointed chin (HP:0000307)1.55914242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.15313483
2BUB13.76206074
3TNIK3.27372742
4MARK13.14812970
5STK163.09901761
6WNK33.07185509
7NUAK12.93481052
8MAP4K22.70438717
9PRPF4B2.66128960
10TRIM282.60981535
11CDK192.53947184
12SRPK12.37835542
13LIMK12.34371450
14ERBB32.30174619
15UHMK12.29304220
16TLK12.27134730
17CASK2.10038203
18MAPK132.09966723
19MINK12.03859311
20PNCK2.03730324
21VRK11.97969926
22MAP3K121.97462672
23STK391.78375138
24WEE11.75477910
25BCR1.74721263
26DYRK21.72472749
27EIF2AK11.61342921
28NTRK31.59927737
29CDC71.58146641
30MKNK11.57474771
31PINK11.52307341
32VRK21.52232677
33TSSK61.46853845
34NTRK21.45803084
35OXSR11.44780119
36MAP2K71.43829523
37TESK21.43757589
38CSNK1G31.42104249
39ZAK1.39736761
40BMPR1B1.38218973
41CCNB11.38060025
42PLK31.32177322
43BRSK11.28323631
44PAK31.28313792
45EPHA41.27507999
46GRK11.27349559
47SIK31.27019879
48MAP3K91.25812095
49CDK141.23503024
50MAP3K41.22401167
51CDK181.18512405
52CDK151.13116519
53CDK11A1.13036588
54CSNK1G21.11691454
55AURKA1.07912586
56PRKCE1.03694476
57TAOK31.00854994
58CSNK1A1L0.95020317
59BMPR20.94723247
60MKNK20.93646459
61PLK20.92981236
62PDK20.92769108
63INSRR0.92681857
64EIF2AK30.91897330
65NME10.90404383
66TTK0.89738335
67WNK40.86593684
68PASK0.86544414
69BRSK20.86317468
70CDK50.85875603
71BRD40.84900762
72LATS10.84713109
73CLK10.84706445
74PLK10.81584478
75PAK60.81430119
76TESK10.80770909
77CAMK2B0.80053350
78STK38L0.79724744
79SCYL20.78890906
80SIK20.78601153
81ROCK20.76304309
82OBSCN0.74714225
83CHEK20.73458124
84TAF10.73324982
85MUSK0.72150073
86RPS6KA40.70800694
87PTK2B0.70374668
88ACVR1B0.68069768
89ATM0.67899488
90ALK0.67378940
91BCKDK0.67270195
92WNK10.66001869
93NLK0.65854822
94CSNK1G10.64171761
95PBK0.61765442
96KSR10.60308117
97CAMKK20.60055108
98ADRBK10.59971316
99FES0.59880062
100DAPK10.59557030
101CDK30.58144018
102TGFBR10.57936596
103RPS6KB20.57310636
104CSNK1D0.54804456
105PRKCG0.54268786
106DYRK1A0.53983016
107PHKG20.53825557
108PHKG10.53825557
109YES10.52954750
110NEK60.50513568
111CHEK10.49126429
112NEK10.47827104
113CSNK1A10.47487638
114DYRK30.47319825
115PIK3CG0.47295863
116FGR0.46998897
117TYRO30.46878462
118EIF2AK20.44703050
119MAP3K110.44505135
120TEC0.44264590
121LATS20.44120851
122FGFR20.43788573
123BRAF0.43530080
124PLK40.42170840
125PKN10.41608956
126CAMK10.40606062
127PRKACB0.40160726
128MARK30.39700434
129PRKACA0.39510137
130CDK10.39279949
131EPHA30.38845030
132PRKD30.38137268
133STK30.37831660
134CAMK2A0.37464923
135AKT30.36873344
136PRKDC0.36870196
137TIE10.36576124
138ADRBK20.35517112
139CAMK2D0.35411558
140MAPK90.34873549
141CSNK1E0.34506074
142CSNK2A20.33819764
143CDK70.33485785
144CDK20.33012478
145AURKB0.31974805
146MAP2K40.31520204
147RPS6KA20.30392449
148ATR0.30013339

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.72963152
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.69010933
3RNA polymerase_Homo sapiens_hsa030202.68973987
4Proteasome_Homo sapiens_hsa030502.67125782
5Spliceosome_Homo sapiens_hsa030402.51480831
6DNA replication_Homo sapiens_hsa030302.48775752
7Mismatch repair_Homo sapiens_hsa034302.38360114
8Protein export_Homo sapiens_hsa030602.34918838
9Oxidative phosphorylation_Homo sapiens_hsa001902.18957876
10Butanoate metabolism_Homo sapiens_hsa006502.14365274
11Nicotine addiction_Homo sapiens_hsa050332.14139341
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05480274
13Parkinsons disease_Homo sapiens_hsa050122.04268855
14Propanoate metabolism_Homo sapiens_hsa006401.99282467
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96013111
16Homologous recombination_Homo sapiens_hsa034401.93599890
17RNA transport_Homo sapiens_hsa030131.90915858
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81367960
19Base excision repair_Homo sapiens_hsa034101.78348288
20Synaptic vesicle cycle_Homo sapiens_hsa047211.77226783
21Nucleotide excision repair_Homo sapiens_hsa034201.75326776
22Oocyte meiosis_Homo sapiens_hsa041141.55308065
23Alzheimers disease_Homo sapiens_hsa050101.52510437
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51577988
25Huntingtons disease_Homo sapiens_hsa050161.47346083
26Dopaminergic synapse_Homo sapiens_hsa047281.45900888
27Pyrimidine metabolism_Homo sapiens_hsa002401.45287740
28Axon guidance_Homo sapiens_hsa043601.45211433
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42808439
30mRNA surveillance pathway_Homo sapiens_hsa030151.40307528
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32770203
32Cell cycle_Homo sapiens_hsa041101.25877065
33Vibrio cholerae infection_Homo sapiens_hsa051101.24016675
34Long-term potentiation_Homo sapiens_hsa047201.23738440
35Peroxisome_Homo sapiens_hsa041461.23030774
36Glutamatergic synapse_Homo sapiens_hsa047241.22057281
37Amphetamine addiction_Homo sapiens_hsa050311.21886370
38Basal transcription factors_Homo sapiens_hsa030221.20818597
39GABAergic synapse_Homo sapiens_hsa047271.19518351
40RNA degradation_Homo sapiens_hsa030181.17243325
41Serotonergic synapse_Homo sapiens_hsa047261.15391976
42Alcoholism_Homo sapiens_hsa050341.15287756
43Selenocompound metabolism_Homo sapiens_hsa004501.13627404
44Non-homologous end-joining_Homo sapiens_hsa034501.13345488
45Olfactory transduction_Homo sapiens_hsa047401.13007824
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12065328
47Morphine addiction_Homo sapiens_hsa050321.11521155
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08716633
49Circadian entrainment_Homo sapiens_hsa047131.07881138
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06030919
51Cholinergic synapse_Homo sapiens_hsa047251.02299310
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.01997360
53Fanconi anemia pathway_Homo sapiens_hsa034601.00054537
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99700619
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95950742
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94647538
57Steroid biosynthesis_Homo sapiens_hsa001000.92119726
58Regulation of autophagy_Homo sapiens_hsa041400.90768208
59Epstein-Barr virus infection_Homo sapiens_hsa051690.90504825
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88323285
61Purine metabolism_Homo sapiens_hsa002300.87220255
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86854763
63Cocaine addiction_Homo sapiens_hsa050300.86114094
64Gap junction_Homo sapiens_hsa045400.85389405
65Fatty acid metabolism_Homo sapiens_hsa012120.84536866
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84441124
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.83827281
68Cardiac muscle contraction_Homo sapiens_hsa042600.81796156
69Long-term depression_Homo sapiens_hsa047300.81563881
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81443270
71Folate biosynthesis_Homo sapiens_hsa007900.80963639
72Collecting duct acid secretion_Homo sapiens_hsa049660.79652848
73One carbon pool by folate_Homo sapiens_hsa006700.79492363
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.79229629
75Circadian rhythm_Homo sapiens_hsa047100.76212115
76Nitrogen metabolism_Homo sapiens_hsa009100.74733065
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73850081
78N-Glycan biosynthesis_Homo sapiens_hsa005100.72965735
79ErbB signaling pathway_Homo sapiens_hsa040120.72519711
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70373231
81Metabolic pathways_Homo sapiens_hsa011000.70226896
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70060477
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69040953
84Tryptophan metabolism_Homo sapiens_hsa003800.67244566
85beta-Alanine metabolism_Homo sapiens_hsa004100.67045938
86Taste transduction_Homo sapiens_hsa047420.66925434
87Ether lipid metabolism_Homo sapiens_hsa005650.66819618
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.63987431
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62806225
90Linoleic acid metabolism_Homo sapiens_hsa005910.62187271
91Colorectal cancer_Homo sapiens_hsa052100.61199471
92Sulfur metabolism_Homo sapiens_hsa009200.60861649
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60195241
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59618043
95Oxytocin signaling pathway_Homo sapiens_hsa049210.59331546
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59166942
97Wnt signaling pathway_Homo sapiens_hsa043100.59138151
98Insulin secretion_Homo sapiens_hsa049110.59030391
99Fatty acid elongation_Homo sapiens_hsa000620.58997625
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58306652
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57728689
102p53 signaling pathway_Homo sapiens_hsa041150.57577609
103Gastric acid secretion_Homo sapiens_hsa049710.57297134
104Renal cell carcinoma_Homo sapiens_hsa052110.56814835
105Caffeine metabolism_Homo sapiens_hsa002320.55085109
106Glioma_Homo sapiens_hsa052140.54781180
107Sulfur relay system_Homo sapiens_hsa041220.54679886
108Melanogenesis_Homo sapiens_hsa049160.51930753
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51473271
110GnRH signaling pathway_Homo sapiens_hsa049120.51404706
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50385447
112Estrogen signaling pathway_Homo sapiens_hsa049150.49442050
113Systemic lupus erythematosus_Homo sapiens_hsa053220.47104383
114Fatty acid degradation_Homo sapiens_hsa000710.45900655
115Hedgehog signaling pathway_Homo sapiens_hsa043400.45425880
116Salivary secretion_Homo sapiens_hsa049700.44176890
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43911113
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43907303
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42552920
120Pyruvate metabolism_Homo sapiens_hsa006200.42436480
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42345656
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41785577
123Endometrial cancer_Homo sapiens_hsa052130.39362874
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.39296257
125Basal cell carcinoma_Homo sapiens_hsa052170.39186382
126Tight junction_Homo sapiens_hsa045300.38562093
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38045044
128Lysine degradation_Homo sapiens_hsa003100.37716521
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37434809
130Glutathione metabolism_Homo sapiens_hsa004800.37209931
131Phototransduction_Homo sapiens_hsa047440.36510451
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36395976
133Non-small cell lung cancer_Homo sapiens_hsa052230.36080733
134Sphingolipid metabolism_Homo sapiens_hsa006000.35402785
135Vitamin B6 metabolism_Homo sapiens_hsa007500.34725060
136Ras signaling pathway_Homo sapiens_hsa040140.34625193
137Viral carcinogenesis_Homo sapiens_hsa052030.34542806
138Renin secretion_Homo sapiens_hsa049240.33030118
139VEGF signaling pathway_Homo sapiens_hsa043700.32368862
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31068743
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28892783
142ABC transporters_Homo sapiens_hsa020100.26641412
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.26604367
144Primary immunodeficiency_Homo sapiens_hsa053400.25539591
145Glycerolipid metabolism_Homo sapiens_hsa005610.24706436

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