EXOSC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.18480544
2DNA strand elongation involved in DNA replication (GO:0006271)4.68449569
3viral transcription (GO:0019083)4.67533096
4translational termination (GO:0006415)4.56744931
5telomere maintenance via semi-conservative replication (GO:0032201)4.52058526
6chaperone-mediated protein transport (GO:0072321)4.46624422
7maturation of SSU-rRNA (GO:0030490)4.46372794
8DNA strand elongation (GO:0022616)4.44502770
9DNA replication initiation (GO:0006270)4.32120812
10ribosomal small subunit biogenesis (GO:0042274)4.27382317
11* DNA deamination (GO:0045006)4.26601738
12translational elongation (GO:0006414)4.19018325
13nucleobase biosynthetic process (GO:0046112)4.11522081
14formation of translation preinitiation complex (GO:0001731)4.09463392
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.04855149
16telomere maintenance via recombination (GO:0000722)4.03130268
17translational initiation (GO:0006413)4.01460675
18ribosomal large subunit biogenesis (GO:0042273)3.99788816
19purine nucleobase biosynthetic process (GO:0009113)3.99141772
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.98896522
21DNA replication checkpoint (GO:0000076)3.98072181
22cotranslational protein targeting to membrane (GO:0006613)3.93510396
23protein targeting to ER (GO:0045047)3.92380342
24ribonucleoprotein complex biogenesis (GO:0022613)3.91164806
25ribosome assembly (GO:0042255)3.88972830
26ribosome biogenesis (GO:0042254)3.81252145
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78285633
28proteasome assembly (GO:0043248)3.77865277
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.77630651
30regulation of mitochondrial translation (GO:0070129)3.76969382
31mitotic recombination (GO:0006312)3.76633972
32DNA unwinding involved in DNA replication (GO:0006268)3.75037273
33CENP-A containing nucleosome assembly (GO:0034080)3.73551886
34protein localization to endoplasmic reticulum (GO:0070972)3.72735159
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.72105359
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.69780424
37chromatin remodeling at centromere (GO:0031055)3.66950930
38telomere maintenance via telomere lengthening (GO:0010833)3.61198802
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.59341262
40regulation of mitotic spindle checkpoint (GO:1903504)3.59341262
41protein localization to kinetochore (GO:0034501)3.58977240
42DNA double-strand break processing (GO:0000729)3.57125286
43viral life cycle (GO:0019058)3.57063040
44cellular protein complex disassembly (GO:0043624)3.56478253
45mitotic metaphase plate congression (GO:0007080)3.51896260
46rRNA methylation (GO:0031167)3.51798455
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46503090
48* rRNA processing (GO:0006364)3.45120110
49histone mRNA metabolic process (GO:0008334)3.44403757
50folic acid-containing compound biosynthetic process (GO:0009396)3.43054465
51spliceosomal snRNP assembly (GO:0000387)3.42262685
52cullin deneddylation (GO:0010388)3.41807858
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.41552229
54DNA replication-independent nucleosome organization (GO:0034724)3.41093376
55DNA replication-independent nucleosome assembly (GO:0006336)3.41093376
56* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40709276
57protein targeting to mitochondrion (GO:0006626)3.39662010
58protein deneddylation (GO:0000338)3.37558099
59translation (GO:0006412)3.36836331
60DNA damage response, detection of DNA damage (GO:0042769)3.35583819
61pseudouridine synthesis (GO:0001522)3.35241700
62replication fork processing (GO:0031297)3.35223206
63respiratory chain complex IV assembly (GO:0008535)3.33819627
64* rRNA metabolic process (GO:0016072)3.33100664
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32214387
66protein localization to chromosome, centromeric region (GO:0071459)3.31860447
67mitotic nuclear envelope disassembly (GO:0007077)3.30088628
68transcription from mitochondrial promoter (GO:0006390)3.28188694
69DNA catabolic process, exonucleolytic (GO:0000738)3.26793635
70DNA replication-dependent nucleosome assembly (GO:0006335)3.26736890
71DNA replication-dependent nucleosome organization (GO:0034723)3.26736890
72maturation of 5.8S rRNA (GO:0000460)3.25613803
73mitochondrial respiratory chain complex assembly (GO:0033108)3.25073335
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24822036
75mitochondrial RNA metabolic process (GO:0000959)3.22743800
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21681855
77ATP synthesis coupled proton transport (GO:0015986)3.21385366
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21385366
79spindle checkpoint (GO:0031577)3.20171667
80protein complex disassembly (GO:0043241)3.19514282
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18259846
82folic acid metabolic process (GO:0046655)3.16728024
83DNA ligation (GO:0006266)3.16020280
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15960813
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.15960813
86NADH dehydrogenase complex assembly (GO:0010257)3.15960813
87kinetochore organization (GO:0051383)3.15375520
88rRNA modification (GO:0000154)3.14566487
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14228081
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14228081
91negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14228081
92negative regulation of mitotic sister chromatid separation (GO:2000816)3.14228081
93negative regulation of sister chromatid segregation (GO:0033046)3.14228081
94positive regulation of ligase activity (GO:0051351)3.14082955
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14034568
96transcription-coupled nucleotide-excision repair (GO:0006283)3.13084389
97protein complex biogenesis (GO:0070271)3.12530371
98histone exchange (GO:0043486)3.12527294
99IMP biosynthetic process (GO:0006188)3.12141707
100mitotic spindle checkpoint (GO:0071174)3.11958384
101protein localization to mitochondrion (GO:0070585)3.11938281
102negative regulation of chromosome segregation (GO:0051985)3.11012023
103pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09580407
104termination of RNA polymerase III transcription (GO:0006386)3.09099845
105transcription elongation from RNA polymerase III promoter (GO:0006385)3.09099845
106establishment of protein localization to mitochondrion (GO:0072655)3.09030137
107mitotic sister chromatid segregation (GO:0000070)3.07558290
108* nuclear-transcribed mRNA catabolic process (GO:0000956)3.06943236
109metaphase plate congression (GO:0051310)3.05899833
110regulation of ubiquitin-protein transferase activity (GO:0051438)3.05626729
111establishment of viral latency (GO:0019043)3.04090793
112membrane disassembly (GO:0030397)3.03928228
113nuclear envelope disassembly (GO:0051081)3.03928228
114macromolecular complex disassembly (GO:0032984)3.03735275
115signal transduction involved in cell cycle checkpoint (GO:0072395)3.02816395
116cellular component biogenesis (GO:0044085)3.01611795
117negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00868792
118negative regulation of ligase activity (GO:0051352)3.00868792
119kinetochore assembly (GO:0051382)2.96225295
120G1/S transition of mitotic cell cycle (GO:0000082)2.96092496
121cell cycle G1/S phase transition (GO:0044843)2.96092496
122regulation of ligase activity (GO:0051340)2.95281204
123mitotic spindle assembly checkpoint (GO:0007094)2.95050125
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.95041107
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94415106
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94415106
127* mRNA catabolic process (GO:0006402)2.90793958
128IMP metabolic process (GO:0046040)2.89980402
129* RNA catabolic process (GO:0006401)2.86571746
130establishment of integrated proviral latency (GO:0075713)2.85679156
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85580062
132spliceosomal complex assembly (GO:0000245)2.85563842
133attachment of spindle microtubules to kinetochore (GO:0008608)2.84809903
134* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84397468
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83017581
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83017581
137signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82468704
138signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82468704
139signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82468704
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79762268
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79739056
142signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78546655
143signal transduction involved in DNA damage checkpoint (GO:0072422)2.78546655
144establishment of chromosome localization (GO:0051303)2.77808528
145telomere organization (GO:0032200)2.77388816
146telomere maintenance (GO:0000723)2.76956162
147termination of RNA polymerase I transcription (GO:0006363)2.76911130
148regulation of spindle organization (GO:0090224)2.76539265
1497-methylguanosine mRNA capping (GO:0006370)2.75883940
150regulation of cellular amino acid metabolic process (GO:0006521)2.75477416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.31346311
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.28006230
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91407001
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27081702
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25109790
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.16011901
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.09534997
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.04290616
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00572806
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.93727553
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89677031
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85161413
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78399188
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75812790
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69389770
16VDR_23849224_ChIP-Seq_CD4+_Human2.41998325
17XRN2_22483619_ChIP-Seq_HELA_Human2.38222020
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29708328
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25877846
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24958743
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22709726
22* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13290308
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11957302
24DCP1A_22483619_ChIP-Seq_HELA_Human2.10748866
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08150960
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05005566
27FOXP3_21729870_ChIP-Seq_TREG_Human2.03336270
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02413584
29* GABP_19822575_ChIP-Seq_HepG2_Human1.94072949
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.89184424
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87750925
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87226596
33AR_21909140_ChIP-Seq_LNCAP_Human1.86743902
34TTF2_22483619_ChIP-Seq_HELA_Human1.79162714
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.76008674
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74602574
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73530300
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71487490
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70529158
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69706422
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66341079
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64465178
43MYC_22102868_ChIP-Seq_BL_Human1.63286980
44ELK1_19687146_ChIP-ChIP_HELA_Human1.62837079
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62647263
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59871524
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59637313
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57341999
49ZNF274_21170338_ChIP-Seq_K562_Hela1.57249598
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.57238969
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.56346333
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54697199
53CIITA_25753668_ChIP-Seq_RAJI_Human1.54210188
54* SRF_21415370_ChIP-Seq_HL-1_Mouse1.52739095
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52638261
56EWS_26573619_Chip-Seq_HEK293_Human1.52565585
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46890365
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41259688
59KDM5A_27292631_Chip-Seq_BREAST_Human1.40670134
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39770675
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35958729
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35776026
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34916722
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.34215400
65FUS_26573619_Chip-Seq_HEK293_Human1.25510529
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21956674
67VDR_22108803_ChIP-Seq_LS180_Human1.21281120
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19754816
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18459999
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17574049
71* SPI1_23547873_ChIP-Seq_NB4_Human1.16055575
72IRF1_19129219_ChIP-ChIP_H3396_Human1.14391657
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.13319052
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13062133
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12776763
76VDR_21846776_ChIP-Seq_THP-1_Human1.11881951
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10361820
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09448220
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08833192
80TFEB_21752829_ChIP-Seq_HELA_Human1.08135525
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07506330
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07260644
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07152640
84* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06189492
85IGF1R_20145208_ChIP-Seq_DFB_Human1.05862117
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03542352
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03383663
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03332212
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.03045250
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02905985
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.99498583
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98702420
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98516995
94MYC_18940864_ChIP-ChIP_HL60_Human0.98131211
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.98020364
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97262227
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93850913
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93229220
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92964715
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91396327
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90500579
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88237031
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88071550
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87955153
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.86987374
106* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86863754
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86711292
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85953782
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85002180
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84787442
111MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84604149
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84565445
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84325928
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82403988
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81633359
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81620382
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80444458
118TAF15_26573619_Chip-Seq_HEK293_Human0.79639024
119STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79596646
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79552301
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78881072
122TP53_22573176_ChIP-Seq_HFKS_Human0.78392578
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.77239849
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75081789
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70887868
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69302444
127ELF5_23300383_ChIP-Seq_T47D_Human0.67625755
128P300_19829295_ChIP-Seq_ESCs_Human0.65158239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.71632762
2MP0004957_abnormal_blastocyst_morpholog4.38166241
3MP0010094_abnormal_chromosome_stability4.22076164
4MP0003111_abnormal_nucleus_morphology4.05406674
5MP0003077_abnormal_cell_cycle3.76404228
6MP0008057_abnormal_DNA_replication3.34543847
7MP0008058_abnormal_DNA_repair3.22419324
8MP0008007_abnormal_cellular_replicative2.87090411
9MP0002396_abnormal_hematopoietic_system2.86853352
10MP0006292_abnormal_olfactory_placode2.59590077
11MP0008932_abnormal_embryonic_tissue2.36965198
12MP0009697_abnormal_copulation2.30184177
13MP0002102_abnormal_ear_morphology2.06400593
14MP0009333_abnormal_splenocyte_physiolog2.00498560
15MP0010352_gastrointestinal_tract_polyps1.98554737
16MP0003786_premature_aging1.97061418
17MP0003806_abnormal_nucleotide_metabolis1.96725915
18MP0000490_abnormal_crypts_of1.96481273
19MP0003763_abnormal_thymus_physiology1.96004551
20MP0001730_embryonic_growth_arrest1.94180285
21MP0000372_irregular_coat_pigmentation1.93522941
22MP0000350_abnormal_cell_proliferation1.93417445
23MP0001529_abnormal_vocalization1.84143019
24MP0006072_abnormal_retinal_apoptosis1.69319823
25MP0004808_abnormal_hematopoietic_stem1.68772364
26MP0002938_white_spotting1.65432681
27MP0003718_maternal_effect1.65043521
28MP0003123_paternal_imprinting1.63076951
29MP0002398_abnormal_bone_marrow1.62205652
30MP0002019_abnormal_tumor_incidence1.61369495
31MP0005397_hematopoietic_system_phenotyp1.60991873
32MP0001545_abnormal_hematopoietic_system1.60991873
33MP0003890_abnormal_embryonic-extraembry1.60422059
34MP0003941_abnormal_skin_development1.58081205
35MP0010307_abnormal_tumor_latency1.57294002
36MP0002722_abnormal_immune_system1.53479014
37MP0003186_abnormal_redox_activity1.50569183
38MP0000689_abnormal_spleen_morphology1.49723040
39MP0000313_abnormal_cell_death1.46944847
40MP0001835_abnormal_antigen_presentation1.45371675
41MP0000703_abnormal_thymus_morphology1.44978988
42MP0008789_abnormal_olfactory_epithelium1.42046254
43MP0001697_abnormal_embryo_size1.39969541
44MP0008877_abnormal_DNA_methylation1.39721229
45MP0001853_heart_inflammation1.38655392
46MP0002080_prenatal_lethality1.38303908
47MP0000685_abnormal_immune_system1.36788041
48MP0005671_abnormal_response_to1.35223385
49MP0001672_abnormal_embryogenesis/_devel1.31293710
50MP0005380_embryogenesis_phenotype1.31293710
51MP0002429_abnormal_blood_cell1.30323416
52MP0001800_abnormal_humoral_immune1.29792252
53MP0003121_genomic_imprinting1.27713391
54MP0000716_abnormal_immune_system1.25205672
55MP0002234_abnormal_pharynx_morphology1.25186326
56MP0003937_abnormal_limbs/digits/tail_de1.22258116
57MP0005410_abnormal_fertilization1.19692556
58MP0009785_altered_susceptibility_to1.19488456
59MP0006054_spinal_hemorrhage1.19062971
60MP0002132_abnormal_respiratory_system1.18889550
61MP0003984_embryonic_growth_retardation1.18560315
62MP0002420_abnormal_adaptive_immunity1.16859253
63MP0002452_abnormal_antigen_presenting1.15972789
64MP0001819_abnormal_immune_cell1.15412345
65MP0002088_abnormal_embryonic_growth/wei1.15156227
66MP0005395_other_phenotype1.12956298
67MP0000358_abnormal_cell_content/1.12489800
68MP0002163_abnormal_gland_morphology1.11744479
69MP0002723_abnormal_immune_serum1.11569857
70MP0005253_abnormal_eye_physiology1.11042948
71MP0002210_abnormal_sex_determination1.07680692
72MP0000858_altered_metastatic_potential1.06995749
73MP0003436_decreased_susceptibility_to1.06533589
74MP0006036_abnormal_mitochondrial_physio1.05917001
75MP0000647_abnormal_sebaceous_gland1.05585831
76MP0002086_abnormal_extraembryonic_tissu1.05424006
77MP0005025_abnormal_response_to1.04515199
78MP0002405_respiratory_system_inflammati1.03650653
79MP0003698_abnormal_male_reproductive1.03371681
80MP0002085_abnormal_embryonic_tissue1.02702014
81MP0005000_abnormal_immune_tolerance1.00342202
82MP0009379_abnormal_foot_pigmentation0.98997214
83MP0008995_early_reproductive_senescence0.98638753
84MP0003567_abnormal_fetal_cardiomyocyte0.97314445
85MP0001929_abnormal_gametogenesis0.97273716
86MP0001145_abnormal_male_reproductive0.97222103
87MP0003656_abnormal_erythrocyte_physiolo0.92266517
88MP0002751_abnormal_autonomic_nervous0.92030843
89MP0000049_abnormal_middle_ear0.91608595
90MP0005499_abnormal_olfactory_system0.90855686
91MP0005394_taste/olfaction_phenotype0.90855686
92MP0005408_hypopigmentation0.90700266
93MP0003119_abnormal_digestive_system0.89974205
94MP0006035_abnormal_mitochondrial_morpho0.89474336
95MP0000631_abnormal_neuroendocrine_gland0.89380418
96MP0002166_altered_tumor_susceptibility0.88963418
97MP0002084_abnormal_developmental_patter0.87961771
98MP0010155_abnormal_intestine_physiology0.87467656
99MP0009840_abnormal_foam_cell0.86624355
100MP0003315_abnormal_perineum_morphology0.86193443
101MP0004197_abnormal_fetal_growth/weight/0.85707040
102MP0004147_increased_porphyrin_level0.85092331
103MP0000653_abnormal_sex_gland0.84634357
104MP0002006_tumorigenesis0.84272983
105MP0002233_abnormal_nose_morphology0.83983985
106MP0002736_abnormal_nociception_after0.82963687
107MP0005075_abnormal_melanosome_morpholog0.82699890
108MP0000516_abnormal_urinary_system0.82647368
109MP0005367_renal/urinary_system_phenotyp0.82647368
110MP0005084_abnormal_gallbladder_morpholo0.82286398
111MP0001873_stomach_inflammation0.82076298
112MP0003136_yellow_coat_color0.81435771
113MP0000465_gastrointestinal_hemorrhage0.81414035
114MP0005187_abnormal_penis_morphology0.79535210
115MP0001286_abnormal_eye_development0.79426654
116MP0002161_abnormal_fertility/fecundity0.79162617
117MP0001188_hyperpigmentation0.79144257
118MP0005379_endocrine/exocrine_gland_phen0.78943313
119MP0002111_abnormal_tail_morphology0.78138921
120MP0003866_abnormal_defecation0.76996067
121MP0005023_abnormal_wound_healing0.76803098
122MP0001119_abnormal_female_reproductive0.75987715
123MP0005389_reproductive_system_phenotype0.75808020
124MP0005384_cellular_phenotype0.75540386
125MP0002095_abnormal_skin_pigmentation0.75525044
126MP0002148_abnormal_hypersensitivity_rea0.75029959
127MP0002090_abnormal_vision0.74963842
128MP0002160_abnormal_reproductive_system0.74082985
129MP0001845_abnormal_inflammatory_respons0.72916421
130MP0005391_vision/eye_phenotype0.72644787
131MP0003699_abnormal_female_reproductive0.72474920
132MP0005551_abnormal_eye_electrophysiolog0.71298120
133MP0001764_abnormal_homeostasis0.71127027
134MP0003195_calcinosis0.70836618
135MP0004133_heterotaxia0.69733586
136MP0005621_abnormal_cell_physiology0.69716334
137MP0000477_abnormal_intestine_morphology0.68740337
138MP0002419_abnormal_innate_immunity0.68170379
139MP0010030_abnormal_orbit_morphology0.67966642
140MP0001727_abnormal_embryo_implantation0.67411163
141MP0005076_abnormal_cell_differentiation0.67346605
142MP0003221_abnormal_cardiomyocyte_apopto0.66885674
143MP0001293_anophthalmia0.66636730
144MP0009672_abnormal_birth_weight0.66496131
145MP0008872_abnormal_physiological_respon0.65929357
146MP0008875_abnormal_xenobiotic_pharmacok0.65642832
147MP0000750_abnormal_muscle_regeneration0.64656742
148MP0003448_altered_tumor_morphology0.64643632
149MP0005387_immune_system_phenotype0.64366507
150MP0001790_abnormal_immune_system0.64366507
151MP0001919_abnormal_reproductive_system0.62293975
152MP0002697_abnormal_eye_size0.61141222
153MP0005645_abnormal_hypothalamus_physiol0.59607478

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.47554477
2Abnormal number of erythroid precursors (HP:0012131)5.37874258
3Reticulocytopenia (HP:0001896)5.13931746
4Birth length less than 3rd percentile (HP:0003561)4.89157556
5Acute necrotizing encephalopathy (HP:0006965)4.36162597
6Acute encephalopathy (HP:0006846)4.07569125
7Oral leukoplakia (HP:0002745)4.01946828
8Abnormal mitochondria in muscle tissue (HP:0008316)3.99380822
9Macrocytic anemia (HP:0001972)3.73140006
10Breast hypoplasia (HP:0003187)3.73055200
11Aplastic anemia (HP:0001915)3.70980257
12Increased CSF lactate (HP:0002490)3.69961196
13Mitochondrial inheritance (HP:0001427)3.67018652
14Progressive macrocephaly (HP:0004481)3.66835860
15Pallor (HP:0000980)3.55661506
16Increased hepatocellular lipid droplets (HP:0006565)3.44752044
17Carpal bone hypoplasia (HP:0001498)3.32277822
18Colon cancer (HP:0003003)3.22669425
19Rough bone trabeculation (HP:0100670)3.15484923
20Lipid accumulation in hepatocytes (HP:0006561)3.14016481
21Cerebral edema (HP:0002181)3.09073766
22Abnormality of the anterior horn cell (HP:0006802)3.07007345
23Degeneration of anterior horn cells (HP:0002398)3.07007345
24Thrombocytosis (HP:0001894)3.02144625
25Microretrognathia (HP:0000308)2.98968046
26IgM deficiency (HP:0002850)2.98042718
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95578222
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95578222
29Multiple enchondromatosis (HP:0005701)2.89749770
30Chromsome breakage (HP:0040012)2.78430428
31Renal Fanconi syndrome (HP:0001994)2.74840080
32Increased serum pyruvate (HP:0003542)2.73364209
33Patellar aplasia (HP:0006443)2.72520902
34Volvulus (HP:0002580)2.69184559
35Absent thumb (HP:0009777)2.65844761
36Selective tooth agenesis (HP:0001592)2.64979461
37Abnormality of the preputium (HP:0100587)2.64842822
38Lactic acidosis (HP:0003128)2.63615495
39Abnormality of the labia minora (HP:0012880)2.61880236
40Abnormal lung lobation (HP:0002101)2.60820217
41Aplasia/Hypoplasia of the patella (HP:0006498)2.57897093
42Microvesicular hepatic steatosis (HP:0001414)2.57445757
433-Methylglutaconic aciduria (HP:0003535)2.57084484
44Abnormality of chromosome stability (HP:0003220)2.56918093
4511 pairs of ribs (HP:0000878)2.56515313
46Meckel diverticulum (HP:0002245)2.56078237
47Trismus (HP:0000211)2.53247525
48Cerebral hypomyelination (HP:0006808)2.52339509
49Type I transferrin isoform profile (HP:0003642)2.51864512
50Premature graying of hair (HP:0002216)2.47851923
51Myelodysplasia (HP:0002863)2.47795009
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47135081
53Abnormality of glycolysis (HP:0004366)2.45792467
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.42286526
55Abnormality of the ileum (HP:0001549)2.39884494
56Bone marrow hypocellularity (HP:0005528)2.38329805
57Agnosia (HP:0010524)2.36858392
58Neoplasm of the pancreas (HP:0002894)2.35840934
59Pancytopenia (HP:0001876)2.35633323
60Lymphoma (HP:0002665)2.33442829
61Methylmalonic acidemia (HP:0002912)2.32478987
62Cellular immunodeficiency (HP:0005374)2.32089019
63Abnormality of serum amino acid levels (HP:0003112)2.32030628
64Increased intramyocellular lipid droplets (HP:0012240)2.30036838
65Hyperglycinemia (HP:0002154)2.28809948
66Abnormal trabecular bone morphology (HP:0100671)2.28244264
67Abnormality of the duodenum (HP:0002246)2.24045832
68Muscle fiber atrophy (HP:0100295)2.22990901
69Entropion (HP:0000621)2.20634983
70Pancreatic cysts (HP:0001737)2.20536295
71Increased serum lactate (HP:0002151)2.20268123
72Abnormality of T cell physiology (HP:0011840)2.20178859
73Progressive muscle weakness (HP:0003323)2.16265461
74IgG deficiency (HP:0004315)2.15403312
75Abnormality of reticulocytes (HP:0004312)2.15364915
76Methylmalonic aciduria (HP:0012120)2.15079012
77Hepatocellular necrosis (HP:0001404)2.14665578
78Leukodystrophy (HP:0002415)2.14367593
79Sparse eyelashes (HP:0000653)2.13539275
80Exercise intolerance (HP:0003546)2.13316721
81Premature ovarian failure (HP:0008209)2.13035485
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.12340746
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12312220
84Abnormality of methionine metabolism (HP:0010901)2.11572056
85Abnormal spermatogenesis (HP:0008669)2.10860836
86Secondary amenorrhea (HP:0000869)2.09719661
87Abnormality of T cells (HP:0002843)2.09532463
88Cleft eyelid (HP:0000625)2.08363276
89Medulloblastoma (HP:0002885)2.07999428
90Respiratory failure (HP:0002878)2.07622596
91Petechiae (HP:0000967)2.06186807
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05997464
93Abnormal protein N-linked glycosylation (HP:0012347)2.05997464
94Abnormal protein glycosylation (HP:0012346)2.05997464
95Abnormal glycosylation (HP:0012345)2.05997464
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05484587
97Exertional dyspnea (HP:0002875)2.05418957
98Hepatic necrosis (HP:0002605)2.05297977
99Supernumerary spleens (HP:0009799)2.04325746
100Poikiloderma (HP:0001029)2.03532735
101Impulsivity (HP:0100710)2.02750372
102Aplasia involving forearm bones (HP:0009822)2.01365470
103Absent forearm bone (HP:0003953)2.01365470
104Pancreatic fibrosis (HP:0100732)2.00295573
105Reduced antithrombin III activity (HP:0001976)1.99847685
106Hypoplasia of the pons (HP:0012110)1.99481753
107Type 2 muscle fiber atrophy (HP:0003554)1.99278698
108Abnormality of midbrain morphology (HP:0002418)1.98858383
109Molar tooth sign on MRI (HP:0002419)1.98858383
110Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98425637
111Nephroblastoma (Wilms tumor) (HP:0002667)1.96743354
112Slender long bone (HP:0003100)1.96655353
113B lymphocytopenia (HP:0010976)1.95977976
114Abnormality of B cell number (HP:0010975)1.95977976
115Lethargy (HP:0001254)1.95484973
116Megaloblastic anemia (HP:0001889)1.95394731
117Small intestinal stenosis (HP:0012848)1.94784450
118Duodenal stenosis (HP:0100867)1.94784450
119Horseshoe kidney (HP:0000085)1.94410566
120Basal cell carcinoma (HP:0002671)1.93984436
121Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93629380
122Combined immunodeficiency (HP:0005387)1.93547995
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93488765
124Abnormality of alanine metabolism (HP:0010916)1.93488765
125Hyperalaninemia (HP:0003348)1.93488765
126Absent radius (HP:0003974)1.93469991
127Abnormality of the pons (HP:0007361)1.93062743
128Respiratory difficulties (HP:0002880)1.92419510
129Embryonal renal neoplasm (HP:0011794)1.92247262
130Elevated erythrocyte sedimentation rate (HP:0003565)1.89962814
131Clubbing of toes (HP:0100760)1.89061877
132Sloping forehead (HP:0000340)1.88484509
133Facial cleft (HP:0002006)1.87928562
134Squamous cell carcinoma (HP:0002860)1.87185748
135Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86249704
136Recurrent bronchitis (HP:0002837)1.85925429
137Granulocytopenia (HP:0001913)1.85908892
138Optic disc pallor (HP:0000543)1.85568730
139Abnormality of the carotid arteries (HP:0005344)1.85339118
140Abnormal biliary tract physiology (HP:0012439)1.85032538
141Bile duct proliferation (HP:0001408)1.85032538
142Triphalangeal thumb (HP:0001199)1.84635282
143Severe combined immunodeficiency (HP:0004430)1.84517096
144Tracheoesophageal fistula (HP:0002575)1.84292889
145Pulmonary fibrosis (HP:0002206)1.84092471
146Abnormality of DNA repair (HP:0003254)1.83242422
147CNS demyelination (HP:0007305)1.82805412
148Atrophy/Degeneration involving motor neurons (HP:0007373)1.80149984
149Abnormality of pyrimidine metabolism (HP:0004353)1.79252517
150Ectopic kidney (HP:0000086)1.79231228
151Rhabdomyosarcoma (HP:0002859)1.78582879
152Amaurosis fugax (HP:0100576)1.78241359
153Pancreatic islet-cell hyperplasia (HP:0004510)1.76396434
154Short tibia (HP:0005736)1.76270051
155Increased muscle lipid content (HP:0009058)1.74587625
156Median cleft lip (HP:0000161)1.72947232
157Neoplasm of the adrenal gland (HP:0100631)1.72562557
158Pendular nystagmus (HP:0012043)1.72061120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.45937832
2WEE14.20151786
3NME23.58288969
4EIF2AK13.21313186
5STK163.07371250
6CDC73.02252550
7PBK2.80177684
8VRK22.61492141
9TRIM282.57295823
10SRPK12.40621481
11NEK22.39641817
12TESK22.33270777
13EIF2AK32.28717294
14PLK42.26684067
15BRSK22.20846114
16NUAK12.06500488
17ACVR1B2.04841633
18DYRK31.92576152
19RPS6KA41.89009140
20KDR1.87288080
21TSSK61.82625366
22VRK11.80782672
23PIM21.73736770
24WNK31.71961612
25TTK1.70127993
26PLK11.60754694
27SCYL21.59630343
28MAP4K11.59098572
29TLK11.53234624
30BMPR1B1.50864064
31AURKB1.48041402
32MAP4K21.45962978
33RPS6KB21.43782855
34PASK1.43273467
35MKNK11.38005735
36CDK71.37620288
37ATR1.34413684
38NEK11.31424301
39PDK21.30529697
40STK101.28617277
41TNIK1.21465143
42BRSK11.19987838
43MAP3K81.19062108
44EEF2K1.16320466
45PAK41.14730625
46CDK41.14245742
47AURKA1.13201804
48FRK1.12786508
49CSNK1G31.12125899
50CCNB11.11615130
51MKNK21.11334115
52CHEK21.10149235
53CSNK1G11.08919580
54FLT31.06517028
55TESK11.06018188
56ZAP701.04232345
57BCR1.01781273
58BLK1.01013767
59TAF11.00195001
60PLK30.99089748
61MAP3K40.98612632
62PIM10.95481528
63ERBB30.94493219
64MAPKAPK30.92363395
65ZAK0.92264368
66MAP3K110.89719731
67CSNK1G20.88512520
68STK40.87838611
69LRRK20.87165948
70TEC0.87154304
71IRAK30.84912540
72MAP3K100.84108908
73CSNK1A1L0.83580836
74CHEK10.83064700
75PLK20.82749559
76BRAF0.80363352
77CDK190.80011735
78INSRR0.79609549
79EPHA20.79334294
80MAP2K70.78464901
81BTK0.75367244
82TGFBR10.74494410
83MAP2K30.74021186
84BCKDK0.71008526
85TXK0.68435531
86TYK20.68100726
87ADRBK20.66060303
88CSNK2A10.64618490
89JAK30.64564296
90CSNK2A20.64168046
91EIF2AK20.63113394
92RPS6KA50.61861240
93GRK10.58894256
94NME10.58794104
95ATM0.58523864
96ERBB40.58262168
97PAK10.58004673
98PDK30.57966040
99PDK40.57966040
100OXSR10.57412212
101IRAK40.56530117
102CDK20.55694945
103CDK80.53411099
104CSF1R0.52207750
105ILK0.51314939
106KIT0.51089643
107CLK10.49366806
108PNCK0.49091019
109MAP3K30.48408324
110NLK0.47276450
111RAF10.43073880
112STK390.42985751
113ABL20.42651613
114STK38L0.41251875
115CSNK1E0.40132360
116PRKCI0.38851244
117IKBKB0.38416249
118GRK60.37794530
119LYN0.37725821
120CDK120.35843898
121CDK10.33135634
122MARK30.32383117
123CDK60.30991121
124MAPK130.30905950
125STK30.30862809
126ALK0.29886734
127CDK30.28460198
128MST40.28268415
129SYK0.27954492
130ARAF0.27771813
131CSNK1A10.27592837
132TBK10.27396611
133DYRK20.26845209
134PRKCG0.26683505
135DAPK10.24124489
136MAP3K120.24048216

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.85322319
2Ribosome_Homo sapiens_hsa030104.31486285
3Mismatch repair_Homo sapiens_hsa034303.88779231
4Proteasome_Homo sapiens_hsa030503.66625120
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40772173
6RNA polymerase_Homo sapiens_hsa030203.37116955
7Spliceosome_Homo sapiens_hsa030403.13904788
8Base excision repair_Homo sapiens_hsa034102.87222664
9Homologous recombination_Homo sapiens_hsa034402.78470737
10Nucleotide excision repair_Homo sapiens_hsa034202.76103088
11Pyrimidine metabolism_Homo sapiens_hsa002402.75103475
12RNA transport_Homo sapiens_hsa030132.73539196
13Cell cycle_Homo sapiens_hsa041102.29017787
14One carbon pool by folate_Homo sapiens_hsa006702.23227890
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03784834
16Non-homologous end-joining_Homo sapiens_hsa034501.99167028
17Fanconi anemia pathway_Homo sapiens_hsa034601.89565962
18Basal transcription factors_Homo sapiens_hsa030221.80463759
19* RNA degradation_Homo sapiens_hsa030181.68036140
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58502919
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49401711
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48867779
23p53 signaling pathway_Homo sapiens_hsa041151.48820832
24Protein export_Homo sapiens_hsa030601.41695418
25Purine metabolism_Homo sapiens_hsa002301.41681730
26Alzheimers disease_Homo sapiens_hsa050101.41367541
27Folate biosynthesis_Homo sapiens_hsa007901.38892096
28Propanoate metabolism_Homo sapiens_hsa006401.38239051
29Steroid biosynthesis_Homo sapiens_hsa001001.28435474
30Pentose phosphate pathway_Homo sapiens_hsa000301.27561087
31Antigen processing and presentation_Homo sapiens_hsa046121.24564169
32Pyruvate metabolism_Homo sapiens_hsa006201.18666169
33Epstein-Barr virus infection_Homo sapiens_hsa051691.17406369
34Primary immunodeficiency_Homo sapiens_hsa053401.15952971
35mRNA surveillance pathway_Homo sapiens_hsa030151.15731563
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13996797
37Fatty acid elongation_Homo sapiens_hsa000621.11674078
38Sulfur relay system_Homo sapiens_hsa041221.10726754
39Systemic lupus erythematosus_Homo sapiens_hsa053221.10544718
40Herpes simplex infection_Homo sapiens_hsa051681.01791172
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00909765
42Vitamin B6 metabolism_Homo sapiens_hsa007501.00835276
43Selenocompound metabolism_Homo sapiens_hsa004501.00156633
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.99686076
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.98645774
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82002380
47Viral carcinogenesis_Homo sapiens_hsa052030.79083582
48Biosynthesis of amino acids_Homo sapiens_hsa012300.78210352
49Legionellosis_Homo sapiens_hsa051340.72470260
50Butanoate metabolism_Homo sapiens_hsa006500.67698934
51Huntingtons disease_Homo sapiens_hsa050160.65977408
52Sulfur metabolism_Homo sapiens_hsa009200.65889982
53N-Glycan biosynthesis_Homo sapiens_hsa005100.65400349
54Glutathione metabolism_Homo sapiens_hsa004800.65229520
55Peroxisome_Homo sapiens_hsa041460.64016452
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60144901
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60134346
58HTLV-I infection_Homo sapiens_hsa051660.59277169
59Measles_Homo sapiens_hsa051620.59113986
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56910975
61Cardiac muscle contraction_Homo sapiens_hsa042600.56165637
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.55798703
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.54707982
64Oocyte meiosis_Homo sapiens_hsa041140.53215556
65Parkinsons disease_Homo sapiens_hsa050120.53054346
66Carbon metabolism_Homo sapiens_hsa012000.51539549
67Phototransduction_Homo sapiens_hsa047440.51333737
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.50622712
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50495543
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49000341
71Apoptosis_Homo sapiens_hsa042100.47646227
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47197388
73Thyroid cancer_Homo sapiens_hsa052160.45568340
74Hematopoietic cell lineage_Homo sapiens_hsa046400.44119748
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42527209
76Fructose and mannose metabolism_Homo sapiens_hsa000510.42228808
77Collecting duct acid secretion_Homo sapiens_hsa049660.42018087
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41722801
79Galactose metabolism_Homo sapiens_hsa000520.41107365
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38057188
81Fatty acid metabolism_Homo sapiens_hsa012120.37462661
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37269350
83Oxidative phosphorylation_Homo sapiens_hsa001900.37259528
84Small cell lung cancer_Homo sapiens_hsa052220.36585896
85Hepatitis B_Homo sapiens_hsa051610.35517825
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35326654
87Metabolic pathways_Homo sapiens_hsa011000.34098995
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33786221
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33464066
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33203515
91Shigellosis_Homo sapiens_hsa051310.32944889
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32156851
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31876895
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31690025
95Asthma_Homo sapiens_hsa053100.31527258
96Tryptophan metabolism_Homo sapiens_hsa003800.29799034
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29267424
98Allograft rejection_Homo sapiens_hsa053300.28072710
99TGF-beta signaling pathway_Homo sapiens_hsa043500.27373769
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26629530
101beta-Alanine metabolism_Homo sapiens_hsa004100.26446992
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26443603
103Regulation of autophagy_Homo sapiens_hsa041400.26113055
104Arginine and proline metabolism_Homo sapiens_hsa003300.25617649
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25285426
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24701684
107Influenza A_Homo sapiens_hsa051640.24064244
108Acute myeloid leukemia_Homo sapiens_hsa052210.23991270
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.23533644
110Fatty acid degradation_Homo sapiens_hsa000710.21658872
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21260974
112Leishmaniasis_Homo sapiens_hsa051400.21136251
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.19824184
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19613561
115Olfactory transduction_Homo sapiens_hsa047400.19282616
116Renin-angiotensin system_Homo sapiens_hsa046140.18826751
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18592176
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.18187302
119Alcoholism_Homo sapiens_hsa050340.17664802
120Vitamin digestion and absorption_Homo sapiens_hsa049770.17650694
121Nitrogen metabolism_Homo sapiens_hsa009100.16931809
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16857486
123Other glycan degradation_Homo sapiens_hsa005110.15167342
124B cell receptor signaling pathway_Homo sapiens_hsa046620.15112154
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14590009
126MicroRNAs in cancer_Homo sapiens_hsa052060.14260435
127Arachidonic acid metabolism_Homo sapiens_hsa005900.13597870
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13531263
129Retinol metabolism_Homo sapiens_hsa008300.13303823
130Caffeine metabolism_Homo sapiens_hsa002320.13020341
131Colorectal cancer_Homo sapiens_hsa052100.12599924
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12432101
133HIF-1 signaling pathway_Homo sapiens_hsa040660.12129154
134T cell receptor signaling pathway_Homo sapiens_hsa046600.11625212
135Graft-versus-host disease_Homo sapiens_hsa053320.11574044
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08904064
137Tyrosine metabolism_Homo sapiens_hsa003500.08087083
138Chemical carcinogenesis_Homo sapiens_hsa052040.07982311

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