

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.78665097 |
| 2 | proteasome assembly (GO:0043248) | 6.52966127 |
| 3 | rRNA modification (GO:0000154) | 5.21417351 |
| 4 | ribosome assembly (GO:0042255) | 5.07764438 |
| 5 | rRNA methylation (GO:0031167) | 4.76594590 |
| 6 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 4.32435343 |
| 7 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 4.32435343 |
| 8 | isotype switching (GO:0045190) | 4.32435343 |
| 9 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.21736398 |
| 10 | cullin deneddylation (GO:0010388) | 4.17554192 |
| 11 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.11735543 |
| 12 | mitotic metaphase plate congression (GO:0007080) | 4.10438455 |
| 13 | protein deneddylation (GO:0000338) | 4.09506959 |
| 14 | transcription from mitochondrial promoter (GO:0006390) | 4.08060068 |
| 15 | CENP-A containing nucleosome assembly (GO:0034080) | 3.99587374 |
| 16 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.96368576 |
| 17 | chaperone-mediated protein transport (GO:0072321) | 3.92654274 |
| 18 | chromatin remodeling at centromere (GO:0031055) | 3.88802133 |
| 19 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.84164373 |
| 20 | DNA replication checkpoint (GO:0000076) | 3.75780694 |
| 21 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.72791146 |
| 22 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.71779162 |
| 23 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.69631674 |
| 24 | negative regulation of ligase activity (GO:0051352) | 3.67479318 |
| 25 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.67479318 |
| 26 | protein localization to kinetochore (GO:0034501) | 3.64330848 |
| 27 | purine nucleobase biosynthetic process (GO:0009113) | 3.63915869 |
| 28 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.60487039 |
| 29 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.58884021 |
| 30 | metaphase plate congression (GO:0051310) | 3.53946065 |
| 31 | nucleobase biosynthetic process (GO:0046112) | 3.53774497 |
| 32 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.45865561 |
| 33 | protein localization to chromosome, centromeric region (GO:0071459) | 3.44048580 |
| 34 | histone exchange (GO:0043486) | 3.43125035 |
| 35 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 3.39989858 |
| 36 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.39406203 |
| 37 | histone mRNA metabolic process (GO:0008334) | 3.37553356 |
| 38 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.36662615 |
| 39 | regulation of mitochondrial translation (GO:0070129) | 3.34337418 |
| 40 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.33937032 |
| 41 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.33937032 |
| 42 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.33937032 |
| 43 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.33255745 |
| 44 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.29629219 |
| 45 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.29629219 |
| 46 | DNA strand elongation (GO:0022616) | 3.29213975 |
| 47 | IMP biosynthetic process (GO:0006188) | 3.26083255 |
| 48 | positive regulation of ligase activity (GO:0051351) | 3.25380198 |
| 49 | somatic diversification of immunoglobulins (GO:0016445) | 3.23619212 |
| 50 | cytokinetic process (GO:0032506) | 3.22610242 |
| 51 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.21685034 |
| 52 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.21685034 |
| 53 | 7-methylguanosine mRNA capping (GO:0006370) | 3.19852523 |
| 54 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.19430293 |
| 55 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.17915372 |
| 56 | pseudouridine synthesis (GO:0001522) | 3.16662163 |
| 57 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.14198395 |
| 58 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.14198395 |
| 59 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.13594572 |
| 60 | ribosomal large subunit biogenesis (GO:0042273) | 3.12924941 |
| 61 | replication fork processing (GO:0031297) | 3.12403771 |
| 62 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.11793852 |
| 63 | rRNA processing (GO:0006364) | 3.11715643 |
| 64 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.11010393 |
| 65 | RNA capping (GO:0036260) | 3.10823686 |
| 66 | 7-methylguanosine RNA capping (GO:0009452) | 3.10823686 |
| 67 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.10126073 |
| 68 | DNA double-strand break processing (GO:0000729) | 3.09658900 |
| 69 | metallo-sulfur cluster assembly (GO:0031163) | 3.08985273 |
| 70 | iron-sulfur cluster assembly (GO:0016226) | 3.08985273 |
| 71 | positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968) | 3.07792394 |
| 72 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.07488119 |
| 73 | DNA replication-independent nucleosome organization (GO:0034724) | 3.07488119 |
| 74 | regulation of ligase activity (GO:0051340) | 3.06098848 |
| 75 | spliceosomal snRNP assembly (GO:0000387) | 3.05599502 |
| 76 | telomere maintenance via recombination (GO:0000722) | 3.05128511 |
| 77 | microtubule depolymerization (GO:0007019) | 3.05032986 |
| 78 | peptidyl-histidine modification (GO:0018202) | 3.01321505 |
| 79 | rRNA metabolic process (GO:0016072) | 2.98457205 |
| 80 | postreplication repair (GO:0006301) | 2.96664041 |
| 81 | protein targeting to mitochondrion (GO:0006626) | 2.93638178 |
| 82 | ncRNA catabolic process (GO:0034661) | 2.89021538 |
| 83 | apoptotic DNA fragmentation (GO:0006309) | 2.88602882 |
| 84 | mitotic recombination (GO:0006312) | 2.88307243 |
| 85 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.85791325 |
| 86 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.83471530 |
| 87 | termination of RNA polymerase III transcription (GO:0006386) | 2.82425925 |
| 88 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.82425925 |
| 89 | somatic cell DNA recombination (GO:0016444) | 2.82281066 |
| 90 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 2.82281066 |
| 91 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.80340921 |
| 92 | methionine metabolic process (GO:0006555) | 2.78364031 |
| 93 | mitotic spindle checkpoint (GO:0071174) | 2.76789408 |
| 94 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.76695691 |
| 95 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.76695691 |
| 96 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.76695691 |
| 97 | maturation of 5.8S rRNA (GO:0000460) | 2.76089837 |
| 98 | mitochondrial RNA metabolic process (GO:0000959) | 2.75669218 |
| 99 | somatic diversification of immune receptors (GO:0002200) | 2.75266888 |
| 100 | tRNA aminoacylation for protein translation (GO:0006418) | 2.74095050 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.76604549 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.68739525 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.17808363 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.71762589 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.68579733 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.36870136 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.28305061 |
| 8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.16020871 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.12976353 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.91694696 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.74550218 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.66729982 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.60502118 |
| 14 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.58028899 |
| 15 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.47436287 |
| 16 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.45740978 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.42255365 |
| 18 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.41547128 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.39868243 |
| 20 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.32632715 |
| 21 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.30260052 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.29227838 |
| 23 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.28999421 |
| 24 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.25782970 |
| 25 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.20429837 |
| 26 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.18019475 |
| 27 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.13167892 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.97912964 |
| 29 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.97674769 |
| 30 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.96321607 |
| 31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.96308117 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.93448302 |
| 33 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.86561501 |
| 34 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.82125112 |
| 35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.75835808 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.75711592 |
| 37 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.75401516 |
| 38 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.75187925 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.73900240 |
| 40 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.73371205 |
| 41 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.62133310 |
| 42 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.60117593 |
| 43 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.58419200 |
| 44 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.58315784 |
| 45 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.56898043 |
| 46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.54978531 |
| 47 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.53283931 |
| 48 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.50763283 |
| 49 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.48045799 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.46735026 |
| 51 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.46276015 |
| 52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.40406063 |
| 53 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.38606751 |
| 54 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.37886841 |
| 55 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.34881681 |
| 56 | EWS_26573619_Chip-Seq_HEK293_Human | 1.34599727 |
| 57 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.34329691 |
| 58 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.32613265 |
| 59 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.30023760 |
| 60 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.25529928 |
| 61 | VDR_22108803_ChIP-Seq_LS180_Human | 1.22621682 |
| 62 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.19031779 |
| 63 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.15478289 |
| 64 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.13592104 |
| 65 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.12422614 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.10214724 |
| 67 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.09846444 |
| 68 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.09161193 |
| 69 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.08959188 |
| 70 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.08764844 |
| 71 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.07429272 |
| 72 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.05110414 |
| 73 | FUS_26573619_Chip-Seq_HEK293_Human | 1.05095746 |
| 74 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.04755622 |
| 75 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04606921 |
| 76 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.03611861 |
| 77 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.98642635 |
| 78 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.96042221 |
| 79 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.95635894 |
| 80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.93578044 |
| 81 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.92187563 |
| 82 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.91624460 |
| 83 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87419126 |
| 84 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.86608315 |
| 85 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.83556742 |
| 86 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.81530302 |
| 87 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.81436646 |
| 88 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.81436646 |
| 89 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.79981082 |
| 90 | AR_20517297_ChIP-Seq_VCAP_Human | 0.77095057 |
| 91 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.76314356 |
| 92 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.76282478 |
| 93 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.74134455 |
| 94 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.73957327 |
| 95 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.72646159 |
| 96 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.72580852 |
| 97 | GATA3_26560356_Chip-Seq_TH2_Human | 0.70449139 |
| 98 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.70057754 |
| 99 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.69320264 |
| 100 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.66754552 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.02649722 |
| 2 | MP0008058_abnormal_DNA_repair | 4.50545948 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.27032556 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.90811195 |
| 5 | MP0009697_abnormal_copulation | 3.82362560 |
| 6 | MP0003111_abnormal_nucleus_morphology | 3.69603848 |
| 7 | MP0008877_abnormal_DNA_methylation | 3.40842492 |
| 8 | MP0005187_abnormal_penis_morphology | 3.06299989 |
| 9 | MP0008057_abnormal_DNA_replication | 3.00587967 |
| 10 | MP0003077_abnormal_cell_cycle | 2.83900148 |
| 11 | MP0006036_abnormal_mitochondrial_physio | 2.59273586 |
| 12 | MP0003786_premature_aging | 2.55129812 |
| 13 | MP0008007_abnormal_cellular_replicative | 2.47886249 |
| 14 | MP0006035_abnormal_mitochondrial_morpho | 2.40211718 |
| 15 | MP0002160_abnormal_reproductive_system | 2.36289870 |
| 16 | MP0002102_abnormal_ear_morphology | 2.03970458 |
| 17 | MP0003718_maternal_effect | 2.02328010 |
| 18 | MP0008932_abnormal_embryonic_tissue | 1.98985479 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 1.83027439 |
| 20 | MP0010386_abnormal_urinary_bladder | 1.79528169 |
| 21 | MP0005389_reproductive_system_phenotype | 1.67969638 |
| 22 | MP0006072_abnormal_retinal_apoptosis | 1.67444176 |
| 23 | MP0005671_abnormal_response_to | 1.62531922 |
| 24 | MP0001730_embryonic_growth_arrest | 1.60756306 |
| 25 | MP0001929_abnormal_gametogenesis | 1.56391287 |
| 26 | MP0000647_abnormal_sebaceous_gland | 1.55636747 |
| 27 | MP0003195_calcinosis | 1.54954770 |
| 28 | MP0002210_abnormal_sex_determination | 1.46063383 |
| 29 | MP0003186_abnormal_redox_activity | 1.45448054 |
| 30 | MP0001764_abnormal_homeostasis | 1.44709104 |
| 31 | MP0001293_anophthalmia | 1.43575706 |
| 32 | MP0005410_abnormal_fertilization | 1.42834151 |
| 33 | MP0005084_abnormal_gallbladder_morpholo | 1.42654941 |
| 34 | MP0003252_abnormal_bile_duct | 1.42266559 |
| 35 | MP0009333_abnormal_splenocyte_physiolog | 1.37097825 |
| 36 | MP0001919_abnormal_reproductive_system | 1.33226877 |
| 37 | MP0008875_abnormal_xenobiotic_pharmacok | 1.31277798 |
| 38 | MP0000358_abnormal_cell_content/ | 1.27405258 |
| 39 | MP0008873_increased_physiological_sensi | 1.26442851 |
| 40 | MP0005253_abnormal_eye_physiology | 1.22131623 |
| 41 | MP0006292_abnormal_olfactory_placode | 1.22088056 |
| 42 | MP0000653_abnormal_sex_gland | 1.21588813 |
| 43 | MP0001145_abnormal_male_reproductive | 1.19264371 |
| 44 | MP0000350_abnormal_cell_proliferation | 1.19004857 |
| 45 | MP0000313_abnormal_cell_death | 1.14224323 |
| 46 | MP0005085_abnormal_gallbladder_physiolo | 1.13386251 |
| 47 | MP0001697_abnormal_embryo_size | 1.12633419 |
| 48 | MP0005360_urolithiasis | 1.12276527 |
| 49 | MP0003221_abnormal_cardiomyocyte_apopto | 1.08172465 |
| 50 | MP0002090_abnormal_vision | 1.06556880 |
| 51 | MP0003698_abnormal_male_reproductive | 1.06227082 |
| 52 | MP0002080_prenatal_lethality | 1.01587205 |
| 53 | MP0001119_abnormal_female_reproductive | 1.00992222 |
| 54 | MP0001727_abnormal_embryo_implantation | 0.99928940 |
| 55 | MP0009785_altered_susceptibility_to | 0.97326649 |
| 56 | MP0005332_abnormal_amino_acid | 0.97271264 |
| 57 | MP0003943_abnormal_hepatobiliary_system | 0.96462936 |
| 58 | MP0010307_abnormal_tumor_latency | 0.96344475 |
| 59 | MP0002019_abnormal_tumor_incidence | 0.96129287 |
| 60 | MP0002938_white_spotting | 0.94558356 |
| 61 | MP0003121_genomic_imprinting | 0.93755381 |
| 62 | MP0006054_spinal_hemorrhage | 0.92088481 |
| 63 | MP0001529_abnormal_vocalization | 0.91742529 |
| 64 | MP0005380_embryogenesis_phenotype | 0.89619605 |
| 65 | MP0001672_abnormal_embryogenesis/_devel | 0.89619605 |
| 66 | MP0003315_abnormal_perineum_morphology | 0.87134030 |
| 67 | MP0000372_irregular_coat_pigmentation | 0.82864409 |
| 68 | MP0005636_abnormal_mineral_homeostasis | 0.82683421 |
| 69 | MP0002095_abnormal_skin_pigmentation | 0.79401834 |
| 70 | MP0003567_abnormal_fetal_cardiomyocyte | 0.78932071 |
| 71 | MP0002085_abnormal_embryonic_tissue | 0.78901950 |
| 72 | MP0002148_abnormal_hypersensitivity_rea | 0.76430891 |
| 73 | MP0001853_heart_inflammation | 0.75225210 |
| 74 | MP0005075_abnormal_melanosome_morpholog | 0.74018309 |
| 75 | MP0000569_abnormal_digit_pigmentation | 0.73444531 |
| 76 | MP0002398_abnormal_bone_marrow | 0.73296296 |
| 77 | MP0002161_abnormal_fertility/fecundity | 0.71277361 |
| 78 | MP0005266_abnormal_metabolism | 0.70255406 |
| 79 | MP0005365_abnormal_bile_salt | 0.69979817 |
| 80 | MP0002139_abnormal_hepatobiliary_system | 0.69864944 |
| 81 | MP0004215_abnormal_myocardial_fiber | 0.69595828 |
| 82 | MP0005645_abnormal_hypothalamus_physiol | 0.69350797 |
| 83 | MP0000689_abnormal_spleen_morphology | 0.68035272 |
| 84 | MP0001879_abnormal_lymphatic_vessel | 0.66796162 |
| 85 | MP0002234_abnormal_pharynx_morphology | 0.66619547 |
| 86 | MP0002006_tumorigenesis | 0.65801810 |
| 87 | MP0000703_abnormal_thymus_morphology | 0.63853391 |
| 88 | MP0002429_abnormal_blood_cell | 0.63201645 |
| 89 | MP0005319_abnormal_enzyme/_coenzyme | 0.63066982 |
| 90 | MP0001188_hyperpigmentation | 0.62769780 |
| 91 | MP0001324_abnormal_eye_pigmentation | 0.62608208 |
| 92 | MP0003984_embryonic_growth_retardation | 0.60672959 |
| 93 | MP0001790_abnormal_immune_system | 0.58269214 |
| 94 | MP0005387_immune_system_phenotype | 0.58269214 |
| 95 | MP0005330_cardiomyopathy | 0.58010616 |
| 96 | MP0002088_abnormal_embryonic_growth/wei | 0.57106377 |
| 97 | MP0005391_vision/eye_phenotype | 0.56204756 |
| 98 | MP0009053_abnormal_anal_canal | 0.56011129 |
| 99 | MP0002138_abnormal_hepatobiliary_system | 0.55770082 |
| 100 | MP0003123_paternal_imprinting | 0.55636225 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sensory axonal neuropathy (HP:0003390) | 4.24493109 |
| 2 | Increased hepatocellular lipid droplets (HP:0006565) | 3.72409299 |
| 3 | Aplastic anemia (HP:0001915) | 3.63949944 |
| 4 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.56736581 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 3.54799711 |
| 6 | Acute encephalopathy (HP:0006846) | 3.46450141 |
| 7 | Increased serum pyruvate (HP:0003542) | 3.31911917 |
| 8 | Abnormality of the labia minora (HP:0012880) | 3.31831343 |
| 9 | Lipid accumulation in hepatocytes (HP:0006561) | 3.29039777 |
| 10 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.14125558 |
| 11 | Increased CSF lactate (HP:0002490) | 3.10634266 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.10625837 |
| 13 | Progressive inability to walk (HP:0002505) | 3.09465378 |
| 14 | Mitochondrial inheritance (HP:0001427) | 3.04895726 |
| 15 | Progressive macrocephaly (HP:0004481) | 2.91678125 |
| 16 | Increased serum lactate (HP:0002151) | 2.91236341 |
| 17 | Poor head control (HP:0002421) | 2.86493542 |
| 18 | Abnormality of glycolysis (HP:0004366) | 2.85886663 |
| 19 | Cerebral edema (HP:0002181) | 2.77951014 |
| 20 | Abnormality of the preputium (HP:0100587) | 2.71984466 |
| 21 | Pancytopenia (HP:0001876) | 2.67184383 |
| 22 | Increased intramyocellular lipid droplets (HP:0012240) | 2.66346832 |
| 23 | Methylmalonic acidemia (HP:0002912) | 2.62916910 |
| 24 | Progressive microcephaly (HP:0000253) | 2.62453752 |
| 25 | Meckel diverticulum (HP:0002245) | 2.61728651 |
| 26 | Hepatic necrosis (HP:0002605) | 2.50994781 |
| 27 | Microvesicular hepatic steatosis (HP:0001414) | 2.50420834 |
| 28 | Abnormality of the ileum (HP:0001549) | 2.49698353 |
| 29 | Hypoglycemic coma (HP:0001325) | 2.47421960 |
| 30 | Renal Fanconi syndrome (HP:0001994) | 2.46654712 |
| 31 | Prominent metopic ridge (HP:0005487) | 2.44888686 |
| 32 | Lactic acidosis (HP:0003128) | 2.41812454 |
| 33 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.40927163 |
| 34 | Hyperglycinemia (HP:0002154) | 2.39658531 |
| 35 | Abnormality of chromosome stability (HP:0003220) | 2.38156785 |
| 36 | Abnormality of serum amino acid levels (HP:0003112) | 2.35677206 |
| 37 | Progressive muscle weakness (HP:0003323) | 2.33519652 |
| 38 | Glycosuria (HP:0003076) | 2.32676736 |
| 39 | Abnormality of urine glucose concentration (HP:0011016) | 2.32676736 |
| 40 | Abnormal protein glycosylation (HP:0012346) | 2.31887144 |
| 41 | Abnormal glycosylation (HP:0012345) | 2.31887144 |
| 42 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.31887144 |
| 43 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.31887144 |
| 44 | Chromsome breakage (HP:0040012) | 2.31072323 |
| 45 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.29309737 |
| 46 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.29309737 |
| 47 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.29299888 |
| 48 | Premature ovarian failure (HP:0008209) | 2.27954446 |
| 49 | Short middle phalanx of the 5th finger (HP:0004220) | 2.27199365 |
| 50 | Progressive external ophthalmoplegia (HP:0000590) | 2.26817752 |
| 51 | Duodenal stenosis (HP:0100867) | 2.26189164 |
| 52 | Small intestinal stenosis (HP:0012848) | 2.26189164 |
| 53 | Methylmalonic aciduria (HP:0012120) | 2.24880335 |
| 54 | Ragged-red muscle fibers (HP:0003200) | 2.20024397 |
| 55 | 3-Methylglutaconic aciduria (HP:0003535) | 2.19458506 |
| 56 | Degeneration of anterior horn cells (HP:0002398) | 2.19040472 |
| 57 | Abnormality of the anterior horn cell (HP:0006802) | 2.19040472 |
| 58 | Hepatocellular necrosis (HP:0001404) | 2.17604927 |
| 59 | Generalized aminoaciduria (HP:0002909) | 2.16572132 |
| 60 | Cleft eyelid (HP:0000625) | 2.15429007 |
| 61 | Multiple enchondromatosis (HP:0005701) | 2.15198183 |
| 62 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.15015389 |
| 63 | Abnormality of alanine metabolism (HP:0010916) | 2.15015389 |
| 64 | Hyperalaninemia (HP:0003348) | 2.15015389 |
| 65 | Birth length less than 3rd percentile (HP:0003561) | 2.14203212 |
| 66 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.13259904 |
| 67 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.11548895 |
| 68 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.09050862 |
| 69 | Single umbilical artery (HP:0001195) | 2.09050862 |
| 70 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.09050862 |
| 71 | Reduced antithrombin III activity (HP:0001976) | 2.07714704 |
| 72 | Hypoplasia of the uterus (HP:0000013) | 2.05858851 |
| 73 | Exertional dyspnea (HP:0002875) | 2.05804780 |
| 74 | Type I transferrin isoform profile (HP:0003642) | 2.05431727 |
| 75 | Lethargy (HP:0001254) | 2.02788924 |
| 76 | Broad distal phalanx of finger (HP:0009836) | 2.02015275 |
| 77 | Increased muscle lipid content (HP:0009058) | 2.02007385 |
| 78 | Colon cancer (HP:0003003) | 2.01356737 |
| 79 | Exercise intolerance (HP:0003546) | 1.99083104 |
| 80 | Abnormality of the metopic suture (HP:0005556) | 1.98990143 |
| 81 | Megaloblastic anemia (HP:0001889) | 1.98147780 |
| 82 | Volvulus (HP:0002580) | 1.98003642 |
| 83 | IgM deficiency (HP:0002850) | 1.97170855 |
| 84 | Abnormality of methionine metabolism (HP:0010901) | 1.94544516 |
| 85 | Facial cleft (HP:0002006) | 1.94481444 |
| 86 | Bone marrow hypocellularity (HP:0005528) | 1.94446438 |
| 87 | Hypergonadotropic hypogonadism (HP:0000815) | 1.93590580 |
| 88 | Impaired proprioception (HP:0010831) | 1.93334882 |
| 89 | Median cleft lip (HP:0000161) | 1.93255517 |
| 90 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.92292797 |
| 91 | Abnormality of glycine metabolism (HP:0010895) | 1.92292797 |
| 92 | Agnosia (HP:0010524) | 1.91232472 |
| 93 | Respiratory difficulties (HP:0002880) | 1.88212202 |
| 94 | IgG deficiency (HP:0004315) | 1.87451509 |
| 95 | Inability to walk (HP:0002540) | 1.87038485 |
| 96 | Clubbing of toes (HP:0100760) | 1.85390257 |
| 97 | Absent thumb (HP:0009777) | 1.84338015 |
| 98 | Hyperglycinuria (HP:0003108) | 1.84065870 |
| 99 | Hypoglycemic seizures (HP:0002173) | 1.83708805 |
| 100 | Dicarboxylic aciduria (HP:0003215) | 1.83214186 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST4 | 5.04193038 |
| 2 | BUB1 | 4.23563022 |
| 3 | NEK1 | 3.20190224 |
| 4 | DYRK3 | 3.10403609 |
| 5 | SRPK1 | 2.93879809 |
| 6 | TRIM28 | 2.91057567 |
| 7 | EIF2AK3 | 2.69937220 |
| 8 | CDC7 | 2.67821698 |
| 9 | PLK4 | 2.57494937 |
| 10 | ZAK | 2.53840363 |
| 11 | TSSK6 | 2.52096651 |
| 12 | TTK | 2.34773309 |
| 13 | PBK | 2.24749994 |
| 14 | EIF2AK1 | 2.20030651 |
| 15 | BCKDK | 2.17448740 |
| 16 | TESK2 | 1.94806419 |
| 17 | WEE1 | 1.83856143 |
| 18 | PLK3 | 1.81111598 |
| 19 | STK16 | 1.74675317 |
| 20 | VRK2 | 1.63026347 |
| 21 | PLK1 | 1.59707295 |
| 22 | RPS6KA4 | 1.50315036 |
| 23 | STK39 | 1.40861894 |
| 24 | VRK1 | 1.34427504 |
| 25 | MKNK1 | 1.33808383 |
| 26 | MAPKAPK3 | 1.32631575 |
| 27 | NUAK1 | 1.31532021 |
| 28 | MAP4K2 | 1.28646738 |
| 29 | WNK3 | 1.23838067 |
| 30 | STK10 | 1.20927778 |
| 31 | LIMK1 | 1.15232468 |
| 32 | EIF2AK2 | 1.14870849 |
| 33 | KDR | 1.12895862 |
| 34 | TLK1 | 1.12679703 |
| 35 | OXSR1 | 1.11856898 |
| 36 | TXK | 1.09988504 |
| 37 | ACVR1B | 1.08696914 |
| 38 | AURKB | 1.07850382 |
| 39 | ATR | 1.06187974 |
| 40 | CLK1 | 1.04418820 |
| 41 | MAP3K4 | 1.02832041 |
| 42 | ERBB3 | 0.97158119 |
| 43 | MKNK2 | 0.95025901 |
| 44 | MAP3K12 | 0.94508923 |
| 45 | PASK | 0.93971868 |
| 46 | BMPR1B | 0.90160193 |
| 47 | INSRR | 0.88008060 |
| 48 | CHEK1 | 0.79440603 |
| 49 | TESK1 | 0.79323603 |
| 50 | WNK4 | 0.77765998 |
| 51 | MST1R | 0.73590281 |
| 52 | BCR | 0.72915002 |
| 53 | CDK19 | 0.72801360 |
| 54 | PLK2 | 0.71956948 |
| 55 | NME2 | 0.70002943 |
| 56 | ABL2 | 0.68925500 |
| 57 | CSNK1G3 | 0.68219285 |
| 58 | FRK | 0.67050676 |
| 59 | AURKA | 0.63593859 |
| 60 | CSNK2A1 | 0.63397821 |
| 61 | TIE1 | 0.62800072 |
| 62 | TNIK | 0.62622518 |
| 63 | ATM | 0.61910601 |
| 64 | CDK7 | 0.59825181 |
| 65 | MAP3K5 | 0.58221423 |
| 66 | AKT2 | 0.57643469 |
| 67 | ADRBK2 | 0.57262968 |
| 68 | CHEK2 | 0.56900548 |
| 69 | CCNB1 | 0.56744151 |
| 70 | CSNK1G1 | 0.56411507 |
| 71 | BMPR2 | 0.55099153 |
| 72 | PDK2 | 0.52696018 |
| 73 | NME1 | 0.52472682 |
| 74 | CSNK2A2 | 0.52448013 |
| 75 | STK4 | 0.51427102 |
| 76 | CSNK1G2 | 0.49128666 |
| 77 | MAP2K7 | 0.47511382 |
| 78 | RPS6KA5 | 0.41649452 |
| 79 | DAPK1 | 0.41356753 |
| 80 | CSNK1A1L | 0.40955651 |
| 81 | MAP3K8 | 0.40481358 |
| 82 | NEK2 | 0.39517673 |
| 83 | GRK1 | 0.37935077 |
| 84 | TGFBR1 | 0.37068723 |
| 85 | ALK | 0.34736401 |
| 86 | MAPKAPK5 | 0.34646751 |
| 87 | CDK4 | 0.34567814 |
| 88 | CDK9 | 0.34290885 |
| 89 | FGFR1 | 0.32338112 |
| 90 | CDK3 | 0.30613184 |
| 91 | STK3 | 0.30371208 |
| 92 | RPS6KB2 | 0.28789069 |
| 93 | CDK8 | 0.28370051 |
| 94 | PRKCI | 0.28310168 |
| 95 | MAP3K3 | 0.28308760 |
| 96 | BRD4 | 0.26722809 |
| 97 | CSNK1A1 | 0.25088475 |
| 98 | MAPK13 | 0.24089570 |
| 99 | TAOK1 | 0.22683419 |
| 100 | BRSK2 | 0.22274950 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.56011761 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.78786063 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.22987607 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.20174954 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.70566654 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.66898882 |
| 7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.53081154 |
| 8 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.36556983 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.33367974 |
| 10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.25921548 |
| 11 | Basal transcription factors_Homo sapiens_hsa03022 | 2.25915816 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.14625942 |
| 13 | RNA degradation_Homo sapiens_hsa03018 | 2.10835759 |
| 14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.07723774 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.02713721 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.01086033 |
| 17 | RNA transport_Homo sapiens_hsa03013 | 1.98934154 |
| 18 | Parkinsons disease_Homo sapiens_hsa05012 | 1.86569619 |
| 19 | Spliceosome_Homo sapiens_hsa03040 | 1.85197745 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.77925672 |
| 21 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.76683499 |
| 22 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.72391682 |
| 23 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.71603606 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.64753292 |
| 25 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.62994282 |
| 26 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.57317662 |
| 27 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.56989753 |
| 28 | Ribosome_Homo sapiens_hsa03010 | 1.41670398 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.40432978 |
| 30 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.39339182 |
| 31 | Huntingtons disease_Homo sapiens_hsa05016 | 1.39063170 |
| 32 | Cell cycle_Homo sapiens_hsa04110 | 1.37586197 |
| 33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.34428558 |
| 34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.33689190 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.24661293 |
| 36 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.15389309 |
| 37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.11564173 |
| 38 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.11466258 |
| 39 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.09077443 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.08462496 |
| 41 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.07400405 |
| 42 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.05372479 |
| 43 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.99656188 |
| 44 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.97724300 |
| 45 | Alzheimers disease_Homo sapiens_hsa05010 | 0.94477720 |
| 46 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.94256069 |
| 47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.93482420 |
| 48 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.91389530 |
| 49 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.90806975 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.87679061 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.86984188 |
| 52 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.86735346 |
| 53 | Carbon metabolism_Homo sapiens_hsa01200 | 0.85945260 |
| 54 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.85276028 |
| 55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.82043551 |
| 56 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.78505190 |
| 57 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.77775274 |
| 58 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.75991786 |
| 59 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.74367126 |
| 60 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.73213246 |
| 61 | Sulfur relay system_Homo sapiens_hsa04122 | 0.71477474 |
| 62 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.70982230 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68497850 |
| 64 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.66136593 |
| 65 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.63887139 |
| 66 | Olfactory transduction_Homo sapiens_hsa04740 | 0.61521677 |
| 67 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.60532380 |
| 68 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.60394616 |
| 69 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.58781172 |
| 70 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.56776536 |
| 71 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.56039175 |
| 72 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.54163618 |
| 73 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.51933387 |
| 74 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.51173756 |
| 75 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47658209 |
| 76 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.47646373 |
| 77 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.45438306 |
| 78 | Phototransduction_Homo sapiens_hsa04744 | 0.39644868 |
| 79 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.39589133 |
| 80 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.38626330 |
| 81 | Retinol metabolism_Homo sapiens_hsa00830 | 0.38576739 |
| 82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.38496600 |
| 83 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.36360821 |
| 84 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.36344505 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.33033162 |
| 86 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.30904690 |
| 87 | Measles_Homo sapiens_hsa05162 | 0.29759723 |
| 88 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.27745504 |
| 89 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.27296425 |
| 90 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.27274281 |
| 91 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.27165599 |
| 92 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.26424337 |
| 93 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.25513501 |
| 94 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.25484926 |
| 95 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.25135757 |
| 96 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.25081365 |
| 97 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.22774975 |
| 98 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.22107310 |
| 99 | Legionellosis_Homo sapiens_hsa05134 | 0.17623775 |
| 100 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.13748720 |

