EXOSC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.76894820
2transcription from mitochondrial promoter (GO:0006390)5.59891000
3replication fork processing (GO:0031297)5.33118048
4proline metabolic process (GO:0006560)5.26481542
5* DNA deamination (GO:0045006)5.13930095
6viral mRNA export from host cell nucleus (GO:0046784)5.13138364
7telomere maintenance via semi-conservative replication (GO:0032201)4.96194827
8formation of translation preinitiation complex (GO:0001731)4.91295503
9proteasome assembly (GO:0043248)4.85782566
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.80688588
11chaperone-mediated protein transport (GO:0072321)4.60274188
12GDP-mannose metabolic process (GO:0019673)4.40434199
13DNA strand elongation involved in DNA replication (GO:0006271)4.37495680
14protein maturation by protein folding (GO:0022417)4.33089735
15oxidative demethylation (GO:0070989)4.21744406
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21675241
17pseudouridine synthesis (GO:0001522)4.19922338
18protein targeting to mitochondrion (GO:0006626)4.18364213
19telomere maintenance via recombination (GO:0000722)4.18042938
20somatic hypermutation of immunoglobulin genes (GO:0016446)4.17703726
21somatic diversification of immune receptors via somatic mutation (GO:0002566)4.17703726
22DNA strand elongation (GO:0022616)4.16140419
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.13971778
24mitochondrial DNA metabolic process (GO:0032042)4.09124503
25nucleotide-excision repair, DNA gap filling (GO:0006297)4.01819893
26ribosome biogenesis (GO:0042254)3.99488583
27ribosome assembly (GO:0042255)3.97867789
28regulation of cellular amino acid metabolic process (GO:0006521)3.92545822
29establishment of protein localization to mitochondrion (GO:0072655)3.88436379
30base-excision repair, AP site formation (GO:0006285)3.84566473
31positive regulation of protein homooligomerization (GO:0032464)3.84033519
32DNA strand renaturation (GO:0000733)3.82020250
33protein localization to mitochondrion (GO:0070585)3.80781967
34telomere maintenance via telomere lengthening (GO:0010833)3.80468113
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.79998216
36ATP synthesis coupled proton transport (GO:0015986)3.78800880
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.78800880
38protein complex biogenesis (GO:0070271)3.78526730
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.77991675
40cullin deneddylation (GO:0010388)3.77805606
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.74275163
42poly(A)+ mRNA export from nucleus (GO:0016973)3.74139000
43respiratory electron transport chain (GO:0022904)3.70564082
44ribosomal small subunit assembly (GO:0000028)3.68678361
45base-excision repair (GO:0006284)3.67679266
46embryonic process involved in female pregnancy (GO:0060136)3.67560970
47kinetochore assembly (GO:0051382)3.66829041
48establishment of integrated proviral latency (GO:0075713)3.66467686
49spliceosomal snRNP assembly (GO:0000387)3.66376155
50iron-sulfur cluster assembly (GO:0016226)3.65671011
51metallo-sulfur cluster assembly (GO:0031163)3.65671011
52DNA integration (GO:0015074)3.63942347
53mitochondrial respiratory chain complex assembly (GO:0033108)3.63620621
54electron transport chain (GO:0022900)3.62126866
55protein deneddylation (GO:0000338)3.61951894
56maturation of SSU-rRNA (GO:0030490)3.61440334
57ribonucleoprotein complex biogenesis (GO:0022613)3.61218793
58peptidyl-arginine omega-N-methylation (GO:0035247)3.58838562
59mitochondrial RNA metabolic process (GO:0000959)3.57849835
60establishment of viral latency (GO:0019043)3.55984893
61lipopolysaccharide biosynthetic process (GO:0009103)3.53965310
62mitotic recombination (GO:0006312)3.52393680
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.51786050
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.50412234
65NADH dehydrogenase complex assembly (GO:0010257)3.50412234
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50412234
67pyrimidine nucleotide catabolic process (GO:0006244)3.48683065
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.46064278
69guanosine-containing compound biosynthetic process (GO:1901070)3.44640543
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.44046121
71termination of RNA polymerase III transcription (GO:0006386)3.44046121
72transcription-coupled nucleotide-excision repair (GO:0006283)3.38362195
73* maturation of 5.8S rRNA (GO:0000460)3.37559274
74viral transcription (GO:0019083)3.36800700
75* rRNA processing (GO:0006364)3.36764708
76deoxyribonucleotide catabolic process (GO:0009264)3.36762286
77ribosomal large subunit biogenesis (GO:0042273)3.36287789
78termination of RNA polymerase II transcription (GO:0006369)3.34267830
79mitochondrial DNA replication (GO:0006264)3.34067073
80translational initiation (GO:0006413)3.33799420
81pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.33305901
82GTP biosynthetic process (GO:0006183)3.33057541
83positive regulation of ligase activity (GO:0051351)3.32868516
84peptidyl-histidine modification (GO:0018202)3.29785434
85DNA double-strand break processing (GO:0000729)3.28942827
86tRNA methylation (GO:0030488)3.27174896
87translational termination (GO:0006415)3.27003424
88double-strand break repair via nonhomologous end joining (GO:0006303)3.26778956
89non-recombinational repair (GO:0000726)3.26778956
90UTP biosynthetic process (GO:0006228)3.26124699
91deoxyribose phosphate catabolic process (GO:0046386)3.25911784
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24905004
93* rRNA metabolic process (GO:0016072)3.23468220
94mitotic G1 DNA damage checkpoint (GO:0031571)3.23322767
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23268104
96pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.22581859
97rRNA modification (GO:0000154)3.21085513
98pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.20670888
99negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.20635239
100regulation of ubiquitin-protein transferase activity (GO:0051438)3.19600240
101cytochrome complex assembly (GO:0017004)3.18632637
102translational elongation (GO:0006414)3.13785742
103inner mitochondrial membrane organization (GO:0007007)3.13155458
104histone arginine methylation (GO:0034969)3.13104804
105kinetochore organization (GO:0051383)3.12563793
106ribosomal small subunit biogenesis (GO:0042274)3.11515604
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11446492
1087-methylguanosine RNA capping (GO:0009452)3.11434890
109RNA capping (GO:0036260)3.11434890
110tRNA modification (GO:0006400)3.11181751
111DNA ligation (GO:0006266)3.10445164
112deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.10370832
113establishment of apical/basal cell polarity (GO:0035089)3.10040396
114nucleobase biosynthetic process (GO:0046112)3.09546009
115mRNA cleavage (GO:0006379)3.09388639
116DNA replication initiation (GO:0006270)3.08582253
117CTP biosynthetic process (GO:0006241)3.08289711
118CTP metabolic process (GO:0046036)3.08289711
119nucleobase-containing small molecule interconversion (GO:0015949)3.08259318
120negative regulation of cell cycle arrest (GO:0071157)3.08232857
121regulation of protein homooligomerization (GO:0032462)3.06458785
122DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05182266
123regulation of ligase activity (GO:0051340)3.05015505
124positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04882073
125pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.04658649
126purine nucleobase biosynthetic process (GO:0009113)3.03959664
127signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03645022
128signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03645022
129signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03645022
130positive regulation of DNA repair (GO:0045739)3.03151823
131respiratory chain complex IV assembly (GO:0008535)3.02574243
132oxidative phosphorylation (GO:0006119)3.02429601
133anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01443185
134protein neddylation (GO:0045116)3.01080894
135DNA replication checkpoint (GO:0000076)3.01068153
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00693945
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00386344
138signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00386344
139antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.00261756
140RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98678889
141tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98678889
142signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98364281
143signal transduction involved in DNA damage checkpoint (GO:0072422)2.98364281
144lipopolysaccharide metabolic process (GO:0008653)2.98130523
145translation (GO:0006412)2.97523981
146negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97309293
147negative regulation of ligase activity (GO:0051352)2.97309293
148SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96836774
149DNA-templated transcription, termination (GO:0006353)2.96660157
150rRNA methylation (GO:0031167)2.96230816
151signal transduction involved in cell cycle checkpoint (GO:0072395)2.95917694
152regulation of cellular amine metabolic process (GO:0033238)2.95472998
153DNA demethylation (GO:0080111)2.94992289
154cellular component biogenesis (GO:0044085)2.93296939
155meiotic chromosome segregation (GO:0045132)2.89161097
156positive regulation of developmental pigmentation (GO:0048087)2.87224217
157cotranslational protein targeting to membrane (GO:0006613)2.85699317
158regulation of mitochondrial translation (GO:0070129)2.85687285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.34338907
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.21852543
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70480140
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59062751
5* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.22023970
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07735989
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.05641698
8* GABP_17652178_ChIP-ChIP_JURKAT_Human2.96010284
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93011836
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81491723
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.78820124
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69901763
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68074783
14* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29228769
15YY1_21170310_ChIP-Seq_MESCs_Mouse2.27502013
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27101580
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20058311
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19806444
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18393462
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16709492
21VDR_23849224_ChIP-Seq_CD4+_Human2.15242662
22XRN2_22483619_ChIP-Seq_HELA_Human2.13928194
23* GABP_19822575_ChIP-Seq_HepG2_Human2.09421664
24* DCP1A_22483619_ChIP-Seq_HELA_Human2.05890574
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03717526
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03631475
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02050985
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97178606
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94767842
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93298141
31* SRF_21415370_ChIP-Seq_HL-1_Mouse1.89840554
32ZNF263_19887448_ChIP-Seq_K562_Human1.87982205
33* TTF2_22483619_ChIP-Seq_HELA_Human1.80138268
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78221805
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78221805
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78221805
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78211433
38FOXP3_21729870_ChIP-Seq_TREG_Human1.74566439
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70929963
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70096936
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69354724
42* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69137599
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66948874
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66486720
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62425687
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60733019
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58873491
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56178552
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53440285
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52918713
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50991003
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50921670
53VDR_21846776_ChIP-Seq_THP-1_Human1.50642709
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.49743844
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.47948963
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46402509
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46001659
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42774436
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40361661
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39869085
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39125198
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38545362
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38345009
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37526884
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37072908
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29109728
67KDM5A_27292631_Chip-Seq_BREAST_Human1.27995629
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25441153
69* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25194354
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23783866
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23407725
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23199333
73* TET1_21451524_ChIP-Seq_MESCs_Mouse1.22684243
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22480260
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22216310
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.21813733
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21581202
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19346869
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18230979
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17730175
81FOXP1_21924763_ChIP-Seq_HESCs_Human1.17529524
82* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16486090
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16427902
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.16315611
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16256471
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.16071102
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15580733
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15491175
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15430133
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.15424990
91ELK1_19687146_ChIP-ChIP_HELA_Human1.15130821
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14556850
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13020568
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.12950251
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12796305
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12228558
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11691181
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11305815
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10068448
100CIITA_25753668_ChIP-Seq_RAJI_Human1.09493488
101TFEB_21752829_ChIP-Seq_HELA_Human1.09224511
102MYC_22102868_ChIP-Seq_BL_Human1.07672080
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.07387657
104* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06613305
105SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05720360
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05307171
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05145277
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02744958
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02311238
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01820849
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00970745
112TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00523013
113* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99223142
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97961210
115* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97729770
116* BCL6_27268052_Chip-Seq_Bcells_Human0.97638956
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97567366
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96577823
119* P68_20966046_ChIP-Seq_HELA_Human0.96498345
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96162747
121* CTCF_26484167_Chip-Seq_Bcells_Mouse0.93168457
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91051485
123* LXR_22292898_ChIP-Seq_THP-1_Human0.88972507
124MYC_18940864_ChIP-ChIP_HL60_Human0.87990457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.74925449
2MP0003693_abnormal_embryo_hatching3.91189446
3MP0010094_abnormal_chromosome_stability3.54427518
4MP0008058_abnormal_DNA_repair3.35915768
5MP0003111_abnormal_nucleus_morphology3.33283045
6MP0004957_abnormal_blastocyst_morpholog3.30220457
7MP0010030_abnormal_orbit_morphology3.14800890
8MP0003786_premature_aging3.01044684
9MP0005451_abnormal_body_composition2.76684247
10MP0003077_abnormal_cell_cycle2.63326752
11MP0005171_absent_coat_pigmentation2.59025691
12MP0000372_irregular_coat_pigmentation2.56583995
13MP0006035_abnormal_mitochondrial_morpho2.51668277
14MP0008932_abnormal_embryonic_tissue2.39028286
15MP0008260_abnormal_autophagy2.38604203
16MP0005058_abnormal_lysosome_morphology2.34265520
17MP0009278_abnormal_bone_marrow2.21508767
18MP0003718_maternal_effect2.15792866
19MP0002254_reproductive_system_inflammat2.09278121
20MP0006292_abnormal_olfactory_placode2.04262389
21MP0008995_early_reproductive_senescence2.04199217
22MP0004133_heterotaxia2.01313577
23MP0004233_abnormal_muscle_weight2.00582887
24MP0002009_preneoplasia1.99233833
25MP0009697_abnormal_copulation1.95380835
26MP0000490_abnormal_crypts_of1.90547383
27MP0005075_abnormal_melanosome_morpholog1.90499434
28MP0002653_abnormal_ependyma_morphology1.83371062
29MP0002132_abnormal_respiratory_system1.82439746
30MP0009840_abnormal_foam_cell1.80147630
31MP0008007_abnormal_cellular_replicative1.79607294
32MP0005174_abnormal_tail_pigmentation1.78107436
33MP0003136_yellow_coat_color1.75714788
34MP0008877_abnormal_DNA_methylation1.67777877
35MP0001545_abnormal_hematopoietic_system1.60486575
36MP0005397_hematopoietic_system_phenotyp1.60486575
37MP0003119_abnormal_digestive_system1.54941190
38MP0000015_abnormal_ear_pigmentation1.54204406
39MP0009333_abnormal_splenocyte_physiolog1.52729505
40MP0002249_abnormal_larynx_morphology1.47782222
41MP0001293_anophthalmia1.46729745
42MP0006072_abnormal_retinal_apoptosis1.44617307
43MP0001727_abnormal_embryo_implantation1.38104618
44MP0003890_abnormal_embryonic-extraembry1.37031163
45MP0003763_abnormal_thymus_physiology1.35735304
46MP0001697_abnormal_embryo_size1.32536522
47MP0005501_abnormal_skin_physiology1.32349022
48MP0000343_altered_response_to1.31927618
49MP0006082_CNS_inflammation1.31071769
50MP0003567_abnormal_fetal_cardiomyocyte1.30912518
51MP0002019_abnormal_tumor_incidence1.29677895
52MP0000049_abnormal_middle_ear1.26052592
53MP0003186_abnormal_redox_activity1.25912636
54MP0000350_abnormal_cell_proliferation1.23191631
55MP0001905_abnormal_dopamine_level1.22964733
56MP0000313_abnormal_cell_death1.22352389
57MP0002085_abnormal_embryonic_tissue1.21272805
58MP0001661_extended_life_span1.20170527
59MP0001873_stomach_inflammation1.19075586
60MP0001730_embryonic_growth_arrest1.18475701
61MP0005410_abnormal_fertilization1.17927468
62MP0005670_abnormal_white_adipose1.16013614
63MP0008789_abnormal_olfactory_epithelium1.14638271
64MP0005380_embryogenesis_phenotype1.13168238
65MP0001672_abnormal_embryogenesis/_devel1.13168238
66MP0000371_diluted_coat_color1.13143983
67MP0001529_abnormal_vocalization1.11902658
68MP0000858_altered_metastatic_potential1.10987929
69MP0002396_abnormal_hematopoietic_system1.10729932
70MP0002736_abnormal_nociception_after1.10718924
71MP0008875_abnormal_xenobiotic_pharmacok1.10713281
72MP0002080_prenatal_lethality1.09687907
73MP0002086_abnormal_extraembryonic_tissu1.09315629
74MP0005367_renal/urinary_system_phenotyp1.07180213
75MP0000516_abnormal_urinary_system1.07180213
76MP0003283_abnormal_digestive_organ1.05779961
77MP0005584_abnormal_enzyme/coenzyme_acti1.05690128
78MP0003806_abnormal_nucleotide_metabolis1.05023975
79MP0002084_abnormal_developmental_patter1.03923517
80MP0003941_abnormal_skin_development1.02028042
81MP0000678_abnormal_parathyroid_gland1.01992211
82MP0002111_abnormal_tail_morphology1.00306469
83MP0005464_abnormal_platelet_physiology0.99970680
84MP0003191_abnormal_cellular_cholesterol0.98584250
85MP0008873_increased_physiological_sensi0.98141411
86MP0001186_pigmentation_phenotype0.96539771
87MP0002405_respiratory_system_inflammati0.93638875
88MP0001145_abnormal_male_reproductive0.93268620
89MP0005408_hypopigmentation0.92907605
90MP0002822_catalepsy0.92463273
91MP0003075_altered_response_to0.92155647
92MP0002210_abnormal_sex_determination0.90358418
93MP0005319_abnormal_enzyme/_coenzyme0.89825517
94MP0002751_abnormal_autonomic_nervous0.89296712
95MP0000470_abnormal_stomach_morphology0.88922513
96MP0004197_abnormal_fetal_growth/weight/0.87875290
97MP0002282_abnormal_trachea_morphology0.87497569
98MP0001881_abnormal_mammary_gland0.87473313
99MP0001919_abnormal_reproductive_system0.87421689
100MP0002075_abnormal_coat/hair_pigmentati0.87370996
101MP0010352_gastrointestinal_tract_polyps0.87181799
102MP0006036_abnormal_mitochondrial_physio0.87135420
103MP0002269_muscular_atrophy0.86787381
104MP0000689_abnormal_spleen_morphology0.86772288
105MP0003011_delayed_dark_adaptation0.85829677
106MP0001346_abnormal_lacrimal_gland0.84869254
107MP0005389_reproductive_system_phenotype0.84605168
108MP0005083_abnormal_biliary_tract0.84340931
109MP0001119_abnormal_female_reproductive0.82814866
110MP0000703_abnormal_thymus_morphology0.82461701
111MP0002163_abnormal_gland_morphology0.82373336
112MP0002148_abnormal_hypersensitivity_rea0.82066884
113MP0000762_abnormal_tongue_morphology0.81200988
114MP0003984_embryonic_growth_retardation0.81013864
115MP0001764_abnormal_homeostasis0.78482157
116MP0005330_cardiomyopathy0.78269954
117MP0003315_abnormal_perineum_morphology0.77262888
118MP0002088_abnormal_embryonic_growth/wei0.77037336
119MP0002722_abnormal_immune_system0.76496755
120MP0005384_cellular_phenotype0.76356187
121MP0002160_abnormal_reproductive_system0.75633675
122MP0000685_abnormal_immune_system0.74839983
123MP0005395_other_phenotype0.74576585
124MP0002114_abnormal_axial_skeleton0.72837656
125MP0000653_abnormal_sex_gland0.71872083
126MP0000537_abnormal_urethra_morphology0.71596961
127MP0002932_abnormal_joint_morphology0.71562768
128MP0001853_heart_inflammation0.71406411
129MP0000681_abnormal_thyroid_gland0.70241626
130MP0002796_impaired_skin_barrier0.70125777
131MP0002398_abnormal_bone_marrow0.70046269
132MP0005332_abnormal_amino_acid0.69542373
133MP0005165_increased_susceptibility_to0.68662966
134MP0002837_dystrophic_cardiac_calcinosis0.67908791
135MP0005636_abnormal_mineral_homeostasis0.67337871
136MP0002938_white_spotting0.65352810
137MP0000358_abnormal_cell_content/0.65218485
138MP0005647_abnormal_sex_gland0.64432411
139MP0001929_abnormal_gametogenesis0.64403723
140MP0003656_abnormal_erythrocyte_physiolo0.64278892
141MP0003453_abnormal_keratinocyte_physiol0.62471065
142MP0005646_abnormal_pituitary_gland0.61699918
143MP0000747_muscle_weakness0.61606109
144MP0002429_abnormal_blood_cell0.61517491
145MP0008469_abnormal_protein_level0.61284186
146MP0003755_abnormal_palate_morphology0.60277512
147MP0000579_abnormal_nail_morphology0.59900250
148MP0009764_decreased_sensitivity_to0.59865164
149MP0005266_abnormal_metabolism0.59843675
150MP0009763_increased_sensitivity_to0.59594541
151MP0010307_abnormal_tumor_latency0.59260280
152MP0009765_abnormal_xenobiotic_induced0.59083678
153MP0003828_pulmonary_edema0.58600051
154MP0002116_abnormal_craniofacial_bone0.58071600
155MP0002095_abnormal_skin_pigmentation0.57082094

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.20446804
2Acute necrotizing encephalopathy (HP:0006965)5.12463743
3Hepatocellular necrosis (HP:0001404)5.06734157
4Mitochondrial inheritance (HP:0001427)4.90738135
5Acute encephalopathy (HP:0006846)4.79590750
6Increased CSF lactate (HP:0002490)4.65542714
7Hepatic necrosis (HP:0002605)4.59976805
8Concave nail (HP:0001598)4.23564730
9Progressive macrocephaly (HP:0004481)3.94032614
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.89102059
11Increased IgM level (HP:0003496)3.82637645
12Increased intramyocellular lipid droplets (HP:0012240)3.75133296
13Poikiloderma (HP:0001029)3.66766297
14Lactic acidosis (HP:0003128)3.64997351
15Rectal fistula (HP:0100590)3.61438202
16Rectovaginal fistula (HP:0000143)3.61438202
17Cerebral edema (HP:0002181)3.48386718
18Rib fusion (HP:0000902)3.47491251
19Absent thumb (HP:0009777)3.46921857
20Patellar aplasia (HP:0006443)3.41138367
21Increased muscle lipid content (HP:0009058)3.40563262
22Increased hepatocellular lipid droplets (HP:0006565)3.39803478
23Selective tooth agenesis (HP:0001592)3.35431533
24Pustule (HP:0200039)3.33588077
25Abnormality of glycolysis (HP:0004366)3.32396863
26Type 2 muscle fiber atrophy (HP:0003554)3.32153465
27Absent radius (HP:0003974)3.31700678
28Renal Fanconi syndrome (HP:0001994)3.29744700
29Premature graying of hair (HP:0002216)3.29091191
30Lipid accumulation in hepatocytes (HP:0006561)3.28205348
31Increased serum pyruvate (HP:0003542)3.26983544
32Tongue fasciculations (HP:0001308)3.25866528
33Aplasia/Hypoplasia of the patella (HP:0006498)3.25830699
34Reticulocytopenia (HP:0001896)3.23252454
35Exercise intolerance (HP:0003546)3.19804206
36Muscle fiber atrophy (HP:0100295)3.19686096
37Vaginal fistula (HP:0004320)3.19293557
38Microvesicular hepatic steatosis (HP:0001414)3.18553743
39Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17564127
40Absent forearm bone (HP:0003953)3.15498535
41Aplasia involving forearm bones (HP:0009822)3.15498535
42Abnormal number of erythroid precursors (HP:0012131)3.10867453
43Respiratory failure (HP:0002878)3.10746207
44Intestinal atresia (HP:0011100)3.10185118
45Breast hypoplasia (HP:0003187)3.07649285
46Intestinal fistula (HP:0100819)3.06919484
47Abnormality of cells of the erythroid lineage (HP:0012130)3.04859139
48Ragged-red muscle fibers (HP:0003200)2.98076301
49Cerebral hypomyelination (HP:0006808)2.94294062
50Annular pancreas (HP:0001734)2.90628006
51Exertional dyspnea (HP:0002875)2.85514002
52Birth length less than 3rd percentile (HP:0003561)2.84996342
53Facial hemangioma (HP:0000329)2.83274039
54Muscle fibrillation (HP:0010546)2.81405538
553-Methylglutaconic aciduria (HP:0003535)2.80730617
56Abnormal protein N-linked glycosylation (HP:0012347)2.77837202
57Abnormal protein glycosylation (HP:0012346)2.77837202
58Abnormal glycosylation (HP:0012345)2.77837202
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.77837202
60Abnormal gallbladder physiology (HP:0012438)2.76984612
61Cholecystitis (HP:0001082)2.76984612
62Abnormal hemoglobin (HP:0011902)2.62971794
63Emotional lability (HP:0000712)2.60245158
64Reduced antithrombin III activity (HP:0001976)2.59186083
65Type I transferrin isoform profile (HP:0003642)2.56557176
66Rough bone trabeculation (HP:0100670)2.56496523
67Abnormality of the ileum (HP:0001549)2.55868603
68Multiple enchondromatosis (HP:0005701)2.55754436
69Aplasia/hypoplasia of the humerus (HP:0006507)2.54942436
70Testicular atrophy (HP:0000029)2.51917037
71Abnormality of lateral ventricle (HP:0030047)2.51519008
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51014959
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51014959
74Abnormality of the anterior horn cell (HP:0006802)2.50230953
75Degeneration of anterior horn cells (HP:0002398)2.50230953
76Hypoplasia of the radius (HP:0002984)2.49031279
77Pancytopenia (HP:0001876)2.48102823
78Lethargy (HP:0001254)2.45338472
79Alopecia of scalp (HP:0002293)2.42943914
80CNS demyelination (HP:0007305)2.40969695
81Abnormality of male internal genitalia (HP:0000022)2.40679885
82Squamous cell carcinoma (HP:0002860)2.40112413
83Redundant skin (HP:0001582)2.38875829
84Abnormality of alanine metabolism (HP:0010916)2.37823092
85Hyperalaninemia (HP:0003348)2.37823092
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37823092
87Bifid uvula (HP:0000193)2.36739300
88Microretrognathia (HP:0000308)2.33754620
89Dysautonomia (HP:0002459)2.33376491
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.32451994
91Dicarboxylic aciduria (HP:0003215)2.31641174
92Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31641174
93Median cleft lip (HP:0000161)2.26739911
94Methylmalonic aciduria (HP:0012120)2.26645170
95Abnormality of the aortic arch (HP:0012303)2.26633204
96Generalized aminoaciduria (HP:0002909)2.23471786
97Spastic paraparesis (HP:0002313)2.21742788
98Petechiae (HP:0000967)2.19513842
99Abnormal number of incisors (HP:0011064)2.19455388
100Hepatosplenomegaly (HP:0001433)2.18927061
101Respiratory difficulties (HP:0002880)2.17918417
102Albinism (HP:0001022)2.16852945
103Broad alveolar ridges (HP:0000187)2.14629533
104Premature ovarian failure (HP:0008209)2.11215069
105Aplasia of the musculature (HP:0100854)2.11112513
106Prolonged neonatal jaundice (HP:0006579)2.11026892
107Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09696013
108Carpal bone hypoplasia (HP:0001498)2.08883783
109Short humerus (HP:0005792)2.08753983
110Increased serum lactate (HP:0002151)2.08715423
111Progressive microcephaly (HP:0000253)2.07328770
112Brushfield spots (HP:0001088)2.07239366
113Oral leukoplakia (HP:0002745)2.06550192
114Leukodystrophy (HP:0002415)2.05096608
115Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04950056
116Basal cell carcinoma (HP:0002671)2.02099076
117Progressive muscle weakness (HP:0003323)2.01306462
118Orthostatic hypotension (HP:0001278)1.99112145
119Sparse eyelashes (HP:0000653)1.98955766
120Diaphragmatic weakness (HP:0009113)1.98137967
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97903592
122Supernumerary spleens (HP:0009799)1.97875067
123Abnormality of the distal phalanges of the toes (HP:0010182)1.96724386
124Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95678572
125Macrocytic anemia (HP:0001972)1.91568100
126Meckel diverticulum (HP:0002245)1.90002545
127Abnormality of T cell physiology (HP:0011840)1.89803439
128Large for gestational age (HP:0001520)1.88600877
129Pallor (HP:0000980)1.88552859
130Optic disc pallor (HP:0000543)1.88262343
131Death in infancy (HP:0001522)1.87674878
132Vertebral hypoplasia (HP:0008417)1.87397472
133Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87397472
134Acute lymphatic leukemia (HP:0006721)1.87364199
135Abnormality of the preputium (HP:0100587)1.86065140
136Gliosis (HP:0002171)1.85225944
137Opisthotonus (HP:0002179)1.84733423
138Capillary hemangiomas (HP:0005306)1.84617197
139Aplastic anemia (HP:0001915)1.84152794
140Short thumb (HP:0009778)1.83993269
141Hypochromic anemia (HP:0001931)1.83989294
142Anteriorly placed anus (HP:0001545)1.82385675
143Chromsome breakage (HP:0040012)1.82038218
144Abnormality of the renal collecting system (HP:0004742)1.80739590
14511 pairs of ribs (HP:0000878)1.79935941
146IgG deficiency (HP:0004315)1.79885240
147Epiphyseal stippling (HP:0010655)1.79131325
148Secondary amenorrhea (HP:0000869)1.79089515
149Abnormality of placental membranes (HP:0011409)1.78918969
150Amniotic constriction ring (HP:0009775)1.78918969
151Aplasia/hypoplasia of the uterus (HP:0008684)1.78582369
152Cerebral palsy (HP:0100021)1.77671137
153Short chin (HP:0000331)1.76733026
154Abnormal trabecular bone morphology (HP:0100671)1.75951608
155Delusions (HP:0000746)1.75584752
156Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75097032
157Fasciculations (HP:0002380)1.74631190
158Premature skin wrinkling (HP:0100678)1.73639242
159Nausea (HP:0002018)1.73392578
160IgA deficiency (HP:0002720)1.72693942
161Hypokinesia (HP:0002375)1.72050074
162Abnormality of methionine metabolism (HP:0010901)1.71587454
163Duplicated collecting system (HP:0000081)1.71490105
164Hypergonadotropic hypogonadism (HP:0000815)1.69146439
165Cheilitis (HP:0100825)1.67309546
166Trismus (HP:0000211)1.67159159
167Hyperglycinemia (HP:0002154)1.66728809
168Abnormality of the umbilical cord (HP:0010881)1.65918614
169Methylmalonic acidemia (HP:0002912)1.63630809
170Cleft eyelid (HP:0000625)1.63401196
171Cholelithiasis (HP:0001081)1.62506958
172Hypertensive crisis (HP:0100735)1.62300173
173Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61561477
174Abnormalities of placenta or umbilical cord (HP:0001194)1.60797412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.77552179
2BUB14.07156263
3MAPK153.72005956
4ICK3.28285264
5PIM23.19039744
6MAP3K113.18147917
7STK162.85164703
8PINK12.83634583
9DDR22.81996505
10MAP3K62.44224992
11ARAF2.35018445
12WEE12.29098426
13PBK2.23228796
14CDK72.02527999
15TLK12.01100612
16NME22.00691193
17DYRK31.94617198
18YES11.91933221
19DAPK11.90574810
20EIF2AK11.89694735
21AKT31.88493028
22SRPK11.85462450
23TESK21.84323607
24SCYL21.80582560
25MATK1.77581301
26IRAK31.72171487
27PLK41.66743767
28NEK11.60088721
29CSNK1G31.57974557
30LIMK11.54952549
31ZAK1.50136704
32PLK11.49845436
33PDK21.44971774
34ABL21.43959426
35BCKDK1.39513654
36UHMK11.36046432
37EPHA21.34604542
38PRKD21.34064581
39PIM11.31004173
40CHEK21.30174278
41DYRK1B1.27159162
42CSNK1A1L1.25511239
43SMG11.22220692
44CDC71.19544323
45TRIM281.19186904
46MST41.18874101
47AURKA1.17838978
48TAOK21.16417760
49FGR1.13861397
50ATR1.12313453
51NUAK11.12283380
52CSK1.11431728
53EIF2AK31.10743637
54BLK1.05748853
55CSNK1G21.03518342
56CSNK1G11.03379470
57DYRK21.02115692
58KDR1.02089070
59MAP4K21.00545197
60ILK0.96715205
61BRAF0.94960151
62MUSK0.94265549
63AURKB0.93000227
64IRAK40.92943904
65MAP2K70.92261369
66RPS6KA50.92242038
67RPS6KC10.90699766
68RPS6KL10.90699766
69RPS6KB20.90008877
70MKNK20.87886549
71VRK10.86736108
72TTK0.85111211
73MAP3K120.83682377
74TBK10.82631754
75MAPK110.82444529
76MAPKAPK30.81473865
77STK38L0.80456368
78MST1R0.79883651
79CSNK2A10.79139346
80RPS6KA60.77841388
81NEK20.77188033
82PLK30.76843881
83NME10.75865525
84DAPK30.75553504
85BRSK20.75287356
86TYRO30.73289296
87TSSK60.71793439
88ERN10.69205328
89TRPM70.69107021
90MKNK10.68280096
91PRKCI0.66642658
92BMX0.66568455
93CDK80.65929721
94CDC42BPA0.65421026
95IRAK10.64378505
96CSNK2A20.60278857
97LATS20.59370519
98PRPF4B0.57602016
99TESK10.57178155
100LYN0.56234863
101PDGFRA0.52450704
102IRAK20.52375653
103CDK20.52074065
104BRSK10.51850641
105RPS6KA40.51343727
106LMTK20.50074202
107PAK10.49426878
108LRRK20.47791463
109CDK60.46684533
110SIK30.45946683
111CCNB10.43895624
112MAP3K100.43832100
113ACVR1B0.43499098
114CHEK10.43257960
115CAMK2G0.43071033
116PASK0.42298207
117MAPKAPK50.41429232
118FLT30.39832905
119RPS6KA10.39637434
120STK40.39461421
121EIF2AK20.38078761
122RAF10.37248270
123CDK40.36740897
124ATM0.36318729
125TXK0.35634213
126TAF10.35126370
127ZAP700.34961738
128PAK40.34550218
129GSK3A0.34435066
130HIPK20.34385124
131IKBKB0.34253069
132MAP3K80.33435555
133ERBB40.32894996
134PHKG20.32722440
135STK100.32619630
136AKT20.31671705
137MAP3K130.31166460
138GRK50.29105074
139CDK90.26028274
140CDK140.23904130
141SIK10.22981319
142CSNK1A10.20525973
143MAP3K30.19353474
144GRK60.16866784

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61767039
2Mismatch repair_Homo sapiens_hsa034304.61385297
3Base excision repair_Homo sapiens_hsa034103.98100314
4Ribosome_Homo sapiens_hsa030103.71258210
5Proteasome_Homo sapiens_hsa030503.67891978
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30104616
7RNA polymerase_Homo sapiens_hsa030203.25108622
8Spliceosome_Homo sapiens_hsa030403.00919293
9Nucleotide excision repair_Homo sapiens_hsa034202.88965503
10Homologous recombination_Homo sapiens_hsa034402.85798348
11RNA transport_Homo sapiens_hsa030132.53607768
12Pyrimidine metabolism_Homo sapiens_hsa002402.30760238
13Fanconi anemia pathway_Homo sapiens_hsa034602.30249929
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.81907341
15Sulfur relay system_Homo sapiens_hsa041221.80830585
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78225091
17One carbon pool by folate_Homo sapiens_hsa006701.78145790
18Fatty acid elongation_Homo sapiens_hsa000621.74136076
19Cell cycle_Homo sapiens_hsa041101.70533382
20Folate biosynthesis_Homo sapiens_hsa007901.67700668
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63261128
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62813496
23p53 signaling pathway_Homo sapiens_hsa041151.55778600
24Basal transcription factors_Homo sapiens_hsa030221.53889518
25Fatty acid biosynthesis_Homo sapiens_hsa000611.49620984
26mRNA surveillance pathway_Homo sapiens_hsa030151.44847739
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44506512
28Sulfur metabolism_Homo sapiens_hsa009201.39299851
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19047557
30Protein export_Homo sapiens_hsa030601.17821814
31Pyruvate metabolism_Homo sapiens_hsa006201.17637715
32Non-homologous end-joining_Homo sapiens_hsa034501.16873354
33Purine metabolism_Homo sapiens_hsa002301.16265075
34* RNA degradation_Homo sapiens_hsa030181.11995709
35Arginine and proline metabolism_Homo sapiens_hsa003301.09742353
36Fructose and mannose metabolism_Homo sapiens_hsa000511.05475643
37Primary immunodeficiency_Homo sapiens_hsa053400.99617314
38Parkinsons disease_Homo sapiens_hsa050120.98878907
39Huntingtons disease_Homo sapiens_hsa050160.98616807
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98318238
41Oxidative phosphorylation_Homo sapiens_hsa001900.97940170
42Biosynthesis of amino acids_Homo sapiens_hsa012300.95649560
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93732312
44Epstein-Barr virus infection_Homo sapiens_hsa051690.91960008
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87231891
46Circadian rhythm_Homo sapiens_hsa047100.85980078
47Galactose metabolism_Homo sapiens_hsa000520.84541930
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82670749
49Peroxisome_Homo sapiens_hsa041460.82600550
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.82096285
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81827076
52Glutathione metabolism_Homo sapiens_hsa004800.79622051
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73926123
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73634140
55Hedgehog signaling pathway_Homo sapiens_hsa043400.73204290
56Notch signaling pathway_Homo sapiens_hsa043300.72735995
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.72115173
58Vibrio cholerae infection_Homo sapiens_hsa051100.70118987
59Steroid biosynthesis_Homo sapiens_hsa001000.69960771
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69845043
61Tyrosine metabolism_Homo sapiens_hsa003500.67864549
62Cardiac muscle contraction_Homo sapiens_hsa042600.65632635
63Herpes simplex infection_Homo sapiens_hsa051680.64508220
64Collecting duct acid secretion_Homo sapiens_hsa049660.63709935
65Phenylalanine metabolism_Homo sapiens_hsa003600.63365692
66Hippo signaling pathway_Homo sapiens_hsa043900.63052370
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62889076
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61463769
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61165110
70Legionellosis_Homo sapiens_hsa051340.60305310
71Pentose phosphate pathway_Homo sapiens_hsa000300.56898888
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56068229
73N-Glycan biosynthesis_Homo sapiens_hsa005100.55978443
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.55268136
75Shigellosis_Homo sapiens_hsa051310.55027561
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54776002
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54749847
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.53448893
79Arachidonic acid metabolism_Homo sapiens_hsa005900.52114051
80Basal cell carcinoma_Homo sapiens_hsa052170.52018883
81Bladder cancer_Homo sapiens_hsa052190.49572014
82Metabolic pathways_Homo sapiens_hsa011000.48069627
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45184244
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44005649
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43680305
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43651624
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.41951621
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41736163
89Fatty acid metabolism_Homo sapiens_hsa012120.40399915
90Lysosome_Homo sapiens_hsa041420.39948552
91Regulation of autophagy_Homo sapiens_hsa041400.38671580
92Viral carcinogenesis_Homo sapiens_hsa052030.38200030
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38172387
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35738621
95TGF-beta signaling pathway_Homo sapiens_hsa043500.34200808
96Thyroid cancer_Homo sapiens_hsa052160.33726421
97Oocyte meiosis_Homo sapiens_hsa041140.33425033
98HTLV-I infection_Homo sapiens_hsa051660.33195512
99Antigen processing and presentation_Homo sapiens_hsa046120.32306327
100Alzheimers disease_Homo sapiens_hsa050100.31509553
101Systemic lupus erythematosus_Homo sapiens_hsa053220.31169973
102Rheumatoid arthritis_Homo sapiens_hsa053230.30687275
103Measles_Homo sapiens_hsa051620.30277148
104Propanoate metabolism_Homo sapiens_hsa006400.30090977
105Alcoholism_Homo sapiens_hsa050340.29990940
106Selenocompound metabolism_Homo sapiens_hsa004500.29626335
107Wnt signaling pathway_Homo sapiens_hsa043100.28527950
108beta-Alanine metabolism_Homo sapiens_hsa004100.23020520
109Other glycan degradation_Homo sapiens_hsa005110.22690750
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21856330
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21411157
112Adherens junction_Homo sapiens_hsa045200.21347103
113Acute myeloid leukemia_Homo sapiens_hsa052210.19865528
114mTOR signaling pathway_Homo sapiens_hsa041500.19709312
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.19636298
116Carbon metabolism_Homo sapiens_hsa012000.18405304
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18081652
118Vitamin B6 metabolism_Homo sapiens_hsa007500.17745493
119Tryptophan metabolism_Homo sapiens_hsa003800.17700032
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17337014
121Salmonella infection_Homo sapiens_hsa051320.16971358
122Apoptosis_Homo sapiens_hsa042100.15225067
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.14943633
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14661093
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14246768
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14208105
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12694379
128Linoleic acid metabolism_Homo sapiens_hsa005910.11058022
129Graft-versus-host disease_Homo sapiens_hsa053320.09485681
130Colorectal cancer_Homo sapiens_hsa052100.06778504

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