

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.40555504 |
| 2 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.81631579 |
| 3 | * DNA deamination (GO:0045006) | 4.80002806 |
| 4 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.78520152 |
| 5 | DNA strand elongation (GO:0022616) | 4.62024466 |
| 6 | chaperone-mediated protein transport (GO:0072321) | 4.61124666 |
| 7 | viral transcription (GO:0019083) | 4.57115447 |
| 8 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.52024486 |
| 9 | translational termination (GO:0006415) | 4.45921534 |
| 10 | maturation of SSU-rRNA (GO:0030490) | 4.44377348 |
| 11 | ribosomal small subunit biogenesis (GO:0042274) | 4.37842769 |
| 12 | DNA replication initiation (GO:0006270) | 4.22607209 |
| 13 | telomere maintenance via recombination (GO:0000722) | 4.21479255 |
| 14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.15418127 |
| 15 | translational elongation (GO:0006414) | 4.13442165 |
| 16 | regulation of mitochondrial translation (GO:0070129) | 4.12315068 |
| 17 | ribosomal large subunit biogenesis (GO:0042273) | 4.09286098 |
| 18 | nucleobase biosynthetic process (GO:0046112) | 4.05366510 |
| 19 | ATP synthesis coupled proton transport (GO:0015986) | 4.04852382 |
| 20 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.04852382 |
| 21 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.95052340 |
| 22 | formation of translation preinitiation complex (GO:0001731) | 3.94265976 |
| 23 | base-excision repair, AP site formation (GO:0006285) | 3.93267066 |
| 24 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.91483452 |
| 25 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.90044906 |
| 26 | protein targeting to mitochondrion (GO:0006626) | 3.89397073 |
| 27 | purine nucleobase biosynthetic process (GO:0009113) | 3.88823129 |
| 28 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.84765888 |
| 29 | mitotic recombination (GO:0006312) | 3.82420432 |
| 30 | cotranslational protein targeting to membrane (GO:0006613) | 3.80247260 |
| 31 | translational initiation (GO:0006413) | 3.79356048 |
| 32 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.79095958 |
| 33 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.79095958 |
| 34 | protein targeting to ER (GO:0045047) | 3.78636133 |
| 35 | telomere maintenance via telomere lengthening (GO:0010833) | 3.74424196 |
| 36 | ribosome biogenesis (GO:0042254) | 3.72826558 |
| 37 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.72338627 |
| 38 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.70503222 |
| 39 | cullin deneddylation (GO:0010388) | 3.68025953 |
| 40 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.66281996 |
| 41 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.65800476 |
| 42 | protein deneddylation (GO:0000338) | 3.64783923 |
| 43 | protein complex biogenesis (GO:0070271) | 3.64363614 |
| 44 | DNA replication checkpoint (GO:0000076) | 3.63612371 |
| 45 | DNA unwinding involved in DNA replication (GO:0006268) | 3.59597287 |
| 46 | protein localization to endoplasmic reticulum (GO:0070972) | 3.58949639 |
| 47 | pseudouridine synthesis (GO:0001522) | 3.58604702 |
| 48 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.58477280 |
| 49 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.58477280 |
| 50 | NADH dehydrogenase complex assembly (GO:0010257) | 3.58477280 |
| 51 | establishment of protein localization to mitochondrion (GO:0072655) | 3.57923590 |
| 52 | deoxyribonucleotide catabolic process (GO:0009264) | 3.57426132 |
| 53 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.57368494 |
| 54 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.56941466 |
| 55 | deoxyribose phosphate catabolic process (GO:0046386) | 3.55535809 |
| 56 | cellular protein complex disassembly (GO:0043624) | 3.53103334 |
| 57 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.51369586 |
| 58 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.51258119 |
| 59 | positive regulation of ligase activity (GO:0051351) | 3.50237463 |
| 60 | respiratory electron transport chain (GO:0022904) | 3.49430695 |
| 61 | protein localization to mitochondrion (GO:0070585) | 3.46051404 |
| 62 | viral life cycle (GO:0019058) | 3.45774599 |
| 63 | respiratory chain complex IV assembly (GO:0008535) | 3.45750011 |
| 64 | establishment of viral latency (GO:0019043) | 3.44880521 |
| 65 | * rRNA processing (GO:0006364) | 3.43388179 |
| 66 | IMP biosynthetic process (GO:0006188) | 3.42652917 |
| 67 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.40643459 |
| 68 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.40643459 |
| 69 | spliceosomal snRNP assembly (GO:0000387) | 3.40631534 |
| 70 | electron transport chain (GO:0022900) | 3.40335454 |
| 71 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.38341250 |
| 72 | chromatin remodeling at centromere (GO:0031055) | 3.38158184 |
| 73 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.38047676 |
| 74 | oxidative phosphorylation (GO:0006119) | 3.35503575 |
| 75 | * rRNA metabolic process (GO:0016072) | 3.33082738 |
| 76 | proteasome assembly (GO:0043248) | 3.31802949 |
| 77 | CENP-A containing nucleosome assembly (GO:0034080) | 3.31586418 |
| 78 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.31233701 |
| 79 | peptidyl-histidine modification (GO:0018202) | 3.31226867 |
| 80 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.28800787 |
| 81 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.26146591 |
| 82 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.25582117 |
| 83 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.24923185 |
| 84 | maturation of 5.8S rRNA (GO:0000460) | 3.24746771 |
| 85 | rRNA methylation (GO:0031167) | 3.24658728 |
| 86 | protein complex disassembly (GO:0043241) | 3.24406204 |
| 87 | rRNA modification (GO:0000154) | 3.23062652 |
| 88 | cytochrome complex assembly (GO:0017004) | 3.22526247 |
| 89 | translation (GO:0006412) | 3.22061339 |
| 90 | mitochondrial RNA metabolic process (GO:0000959) | 3.20583310 |
| 91 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.19465015 |
| 92 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.17743610 |
| 93 | regulation of ligase activity (GO:0051340) | 3.16906895 |
| 94 | negative regulation of B cell apoptotic process (GO:0002903) | 3.15866738 |
| 95 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.15195332 |
| 96 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.14565938 |
| 97 | mitotic metaphase plate congression (GO:0007080) | 3.12106141 |
| 98 | protein localization to kinetochore (GO:0034501) | 3.09276349 |
| 99 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.08419917 |
| 100 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.08419917 |
| 101 | ribosome assembly (GO:0042255) | 3.07576910 |
| 102 | macromolecular complex disassembly (GO:0032984) | 3.06752365 |
| 103 | cellular component biogenesis (GO:0044085) | 3.03573039 |
| 104 | IMP metabolic process (GO:0046040) | 3.02421342 |
| 105 | protein localization to chromosome, centromeric region (GO:0071459) | 3.00925324 |
| 106 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.97102844 |
| 107 | DNA replication-independent nucleosome organization (GO:0034724) | 2.97102844 |
| 108 | * nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.97014181 |
| 109 | mitotic nuclear envelope disassembly (GO:0007077) | 2.95027972 |
| 110 | telomere organization (GO:0032200) | 2.94877415 |
| 111 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.94193880 |
| 112 | telomere maintenance (GO:0000723) | 2.94046977 |
| 113 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.93618983 |
| 114 | termination of RNA polymerase III transcription (GO:0006386) | 2.93336997 |
| 115 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.93336997 |
| 116 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.92648199 |
| 117 | histone exchange (GO:0043486) | 2.86552722 |
| 118 | establishment of integrated proviral latency (GO:0075713) | 2.86483450 |
| 119 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.85289931 |
| 120 | kinetochore assembly (GO:0051382) | 2.84604443 |
| 121 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.83471257 |
| 122 | * exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.83365526 |
| 123 | kinetochore organization (GO:0051383) | 2.83359068 |
| 124 | * mRNA catabolic process (GO:0006402) | 2.82914957 |
| 125 | * RNA catabolic process (GO:0006401) | 2.82062535 |
| 126 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.77738079 |
| 127 | tRNA methylation (GO:0030488) | 2.76931279 |
| 128 | viral mRNA export from host cell nucleus (GO:0046784) | 2.74806407 |
| 129 | * nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.72832688 |
| 130 | negative regulation of ligase activity (GO:0051352) | 2.72293318 |
| 131 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.72293318 |
| 132 | * ncRNA processing (GO:0034470) | 2.71105621 |
| 133 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.70635092 |
| 134 | cell cycle G1/S phase transition (GO:0044843) | 2.70406757 |
| 135 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.70406757 |
| 136 | * ncRNA metabolic process (GO:0034660) | 2.70102331 |
| 137 | folic acid metabolic process (GO:0046655) | 2.69472297 |
| 138 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.69146490 |
| 139 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.69146490 |
| 140 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.69146490 |
| 141 | metaphase plate congression (GO:0051310) | 2.69045228 |
| 142 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.68688197 |
| 143 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.68688197 |
| 144 | spliceosomal complex assembly (GO:0000245) | 2.68313059 |
| 145 | termination of RNA polymerase II transcription (GO:0006369) | 2.68252399 |
| 146 | termination of RNA polymerase I transcription (GO:0006363) | 2.68012003 |
| 147 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.67931908 |
| 148 | DNA-templated transcription, termination (GO:0006353) | 2.64487244 |
| 149 | base-excision repair (GO:0006284) | 2.64378430 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.02117622 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.11952305 |
| 3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.67694734 |
| 4 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.03854283 |
| 5 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.00726732 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.93834178 |
| 7 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.93383174 |
| 8 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.90667114 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.82150170 |
| 10 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.79724814 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.78937692 |
| 12 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.71497588 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.65810405 |
| 14 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.64755273 |
| 15 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.60570298 |
| 16 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.49340771 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.49166319 |
| 18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.48441963 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.38179689 |
| 20 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.28215436 |
| 21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.23940809 |
| 22 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.13155019 |
| 23 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.11883941 |
| 24 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.06933654 |
| 25 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.05808295 |
| 26 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.99767508 |
| 27 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.96085201 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.89902603 |
| 29 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.89511353 |
| 30 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.87568104 |
| 31 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.85999592 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.78628784 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.74453888 |
| 34 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.72945631 |
| 35 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.72838163 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.69825566 |
| 37 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.69657337 |
| 38 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.66798549 |
| 39 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.65290295 |
| 40 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.65226260 |
| 41 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.63826413 |
| 42 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.62538287 |
| 43 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.62311551 |
| 44 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.57956079 |
| 45 | MYC_22102868_ChIP-Seq_BL_Human | 1.54736055 |
| 46 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.54456212 |
| 47 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.53471427 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.51106882 |
| 49 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.50747546 |
| 50 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48967030 |
| 51 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.45760167 |
| 52 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.43030322 |
| 53 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.42519782 |
| 54 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.42295038 |
| 55 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.41415829 |
| 56 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.39685328 |
| 57 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.37041994 |
| 58 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.31612609 |
| 59 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.27941166 |
| 60 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.27896287 |
| 61 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.27461622 |
| 62 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.26999696 |
| 63 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.22748557 |
| 64 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.17278508 |
| 65 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.17182915 |
| 66 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.16248493 |
| 67 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.15202870 |
| 68 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14672655 |
| 69 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.13330905 |
| 70 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.11492044 |
| 71 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.10317470 |
| 72 | * POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.09015851 |
| 73 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.08068335 |
| 74 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.06200209 |
| 75 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.05962470 |
| 76 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.04245341 |
| 77 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.04239881 |
| 78 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.03932652 |
| 79 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.03740957 |
| 80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.03384682 |
| 81 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.02890630 |
| 82 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.02286644 |
| 83 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.99355981 |
| 84 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.98557493 |
| 85 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.97750890 |
| 86 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.96783168 |
| 87 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.95612034 |
| 88 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.94529064 |
| 89 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.92490717 |
| 90 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.92190357 |
| 91 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.91526543 |
| 92 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91358689 |
| 93 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.91261276 |
| 94 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.90919689 |
| 95 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.90672187 |
| 96 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.87974163 |
| 97 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.87173059 |
| 98 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87001051 |
| 99 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.86229763 |
| 100 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.86226300 |
| 101 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.85830397 |
| 102 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.84519689 |
| 103 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.84328116 |
| 104 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.83688217 |
| 105 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.83121131 |
| 106 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.82589244 |
| 107 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.81994366 |
| 108 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.80120979 |
| 109 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.79565785 |
| 110 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.74253543 |
| 111 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.73513172 |
| 112 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.71124100 |
| 113 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.70343032 |
| 114 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.67199548 |
| 115 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.66636428 |
| 116 | * NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.66498922 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.09121070 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.13410495 |
| 3 | MP0003111_abnormal_nucleus_morphology | 3.96584113 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.87599866 |
| 5 | MP0008057_abnormal_DNA_replication | 3.86318937 |
| 6 | MP0008058_abnormal_DNA_repair | 3.48743821 |
| 7 | MP0003077_abnormal_cell_cycle | 3.47382553 |
| 8 | MP0002396_abnormal_hematopoietic_system | 2.90755720 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.67276293 |
| 10 | MP0003806_abnormal_nucleotide_metabolis | 2.54707063 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.25367616 |
| 12 | MP0003786_premature_aging | 2.10366457 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.09428129 |
| 14 | MP0000490_abnormal_crypts_of | 2.01686565 |
| 15 | MP0003763_abnormal_thymus_physiology | 1.93456485 |
| 16 | MP0008877_abnormal_DNA_methylation | 1.91286527 |
| 17 | MP0005410_abnormal_fertilization | 1.91256850 |
| 18 | MP0001835_abnormal_antigen_presentation | 1.75573344 |
| 19 | MP0009333_abnormal_splenocyte_physiolog | 1.75230767 |
| 20 | MP0001545_abnormal_hematopoietic_system | 1.74601708 |
| 21 | MP0005397_hematopoietic_system_phenotyp | 1.74601708 |
| 22 | MP0001730_embryonic_growth_arrest | 1.73165950 |
| 23 | MP0003186_abnormal_redox_activity | 1.71253983 |
| 24 | MP0005075_abnormal_melanosome_morpholog | 1.68664789 |
| 25 | MP0004808_abnormal_hematopoietic_stem | 1.66180089 |
| 26 | MP0000350_abnormal_cell_proliferation | 1.66099090 |
| 27 | MP0003646_muscle_fatigue | 1.65799572 |
| 28 | MP0010352_gastrointestinal_tract_polyps | 1.59097472 |
| 29 | MP0002019_abnormal_tumor_incidence | 1.58513528 |
| 30 | MP0002398_abnormal_bone_marrow | 1.54711274 |
| 31 | MP0002837_dystrophic_cardiac_calcinosis | 1.54179637 |
| 32 | MP0001929_abnormal_gametogenesis | 1.52808091 |
| 33 | MP0000313_abnormal_cell_death | 1.50072847 |
| 34 | MP0002102_abnormal_ear_morphology | 1.49717917 |
| 35 | MP0002210_abnormal_sex_determination | 1.47189702 |
| 36 | MP0002132_abnormal_respiratory_system | 1.44851370 |
| 37 | MP0000689_abnormal_spleen_morphology | 1.44740707 |
| 38 | MP0002722_abnormal_immune_system | 1.42507030 |
| 39 | MP0005174_abnormal_tail_pigmentation | 1.40867915 |
| 40 | MP0010307_abnormal_tumor_latency | 1.40641273 |
| 41 | MP0001529_abnormal_vocalization | 1.37184033 |
| 42 | MP0003718_maternal_effect | 1.35818037 |
| 43 | MP0002736_abnormal_nociception_after | 1.33213064 |
| 44 | MP0001145_abnormal_male_reproductive | 1.30154681 |
| 45 | MP0001853_heart_inflammation | 1.29689561 |
| 46 | MP0008872_abnormal_physiological_respon | 1.28508603 |
| 47 | MP0005645_abnormal_hypothalamus_physiol | 1.27613523 |
| 48 | MP0000703_abnormal_thymus_morphology | 1.27605330 |
| 49 | MP0005646_abnormal_pituitary_gland | 1.26483794 |
| 50 | MP0002429_abnormal_blood_cell | 1.26192092 |
| 51 | MP0001986_abnormal_taste_sensitivity | 1.24670821 |
| 52 | MP0005671_abnormal_response_to | 1.24474308 |
| 53 | MP0000685_abnormal_immune_system | 1.23455540 |
| 54 | MP0000716_abnormal_immune_system | 1.20328902 |
| 55 | MP0006036_abnormal_mitochondrial_physio | 1.19753606 |
| 56 | MP0002080_prenatal_lethality | 1.19522178 |
| 57 | MP0001800_abnormal_humoral_immune | 1.18838079 |
| 58 | MP0001764_abnormal_homeostasis | 1.18091965 |
| 59 | MP0009379_abnormal_foot_pigmentation | 1.17932429 |
| 60 | MP0009785_altered_susceptibility_to | 1.17082620 |
| 61 | MP0002160_abnormal_reproductive_system | 1.16936736 |
| 62 | MP0006292_abnormal_olfactory_placode | 1.15737813 |
| 63 | MP0005380_embryogenesis_phenotype | 1.15269756 |
| 64 | MP0001672_abnormal_embryogenesis/_devel | 1.15269756 |
| 65 | MP0001697_abnormal_embryo_size | 1.13421904 |
| 66 | MP0003136_yellow_coat_color | 1.12506344 |
| 67 | MP0002420_abnormal_adaptive_immunity | 1.10008061 |
| 68 | MP0005025_abnormal_response_to | 1.09624800 |
| 69 | MP0002938_white_spotting | 1.09200215 |
| 70 | MP0000653_abnormal_sex_gland | 1.09053001 |
| 71 | MP0002163_abnormal_gland_morphology | 1.08260203 |
| 72 | MP0001819_abnormal_immune_cell | 1.08164784 |
| 73 | MP0008875_abnormal_xenobiotic_pharmacok | 1.08126695 |
| 74 | MP0005084_abnormal_gallbladder_morpholo | 1.06842540 |
| 75 | MP0000858_altered_metastatic_potential | 1.06076952 |
| 76 | MP0002723_abnormal_immune_serum | 1.05937282 |
| 77 | MP0003698_abnormal_male_reproductive | 1.05871807 |
| 78 | MP0002452_abnormal_antigen_presenting | 1.04155721 |
| 79 | MP0003123_paternal_imprinting | 1.03776959 |
| 80 | MP0000015_abnormal_ear_pigmentation | 1.01831625 |
| 81 | MP0003984_embryonic_growth_retardation | 1.00654292 |
| 82 | MP0000358_abnormal_cell_content/ | 1.00097218 |
| 83 | MP0005464_abnormal_platelet_physiology | 0.98960040 |
| 84 | MP0002405_respiratory_system_inflammati | 0.97378100 |
| 85 | MP0002095_abnormal_skin_pigmentation | 0.97111802 |
| 86 | MP0002088_abnormal_embryonic_growth/wei | 0.95942265 |
| 87 | MP0002653_abnormal_ependyma_morphology | 0.94869826 |
| 88 | MP0001873_stomach_inflammation | 0.93566451 |
| 89 | MP0003436_decreased_susceptibility_to | 0.93095007 |
| 90 | MP0008789_abnormal_olfactory_epithelium | 0.92253987 |
| 91 | MP0005389_reproductive_system_phenotype | 0.91320548 |
| 92 | MP0008995_early_reproductive_senescence | 0.89972101 |
| 93 | MP0005330_cardiomyopathy | 0.89346224 |
| 94 | MP0008873_increased_physiological_sensi | 0.88479758 |
| 95 | MP0005000_abnormal_immune_tolerance | 0.86684665 |
| 96 | MP0001661_extended_life_span | 0.86558607 |
| 97 | MP0002086_abnormal_extraembryonic_tissu | 0.85904290 |
| 98 | MP0010155_abnormal_intestine_physiology | 0.85791504 |
| 99 | MP0002085_abnormal_embryonic_tissue | 0.85668860 |
| 100 | MP0000749_muscle_degeneration | 0.85652384 |
| 101 | MP0001293_anophthalmia | 0.85644593 |
| 102 | MP0002166_altered_tumor_susceptibility | 0.85357649 |
| 103 | MP0006035_abnormal_mitochondrial_morpho | 0.84110108 |
| 104 | MP0000465_gastrointestinal_hemorrhage | 0.83265091 |
| 105 | MP0002148_abnormal_hypersensitivity_rea | 0.83186651 |
| 106 | MP0006072_abnormal_retinal_apoptosis | 0.82859745 |
| 107 | MP0002006_tumorigenesis | 0.79938082 |
| 108 | MP0009697_abnormal_copulation | 0.79177334 |
| 109 | MP0001119_abnormal_female_reproductive | 0.78602169 |
| 110 | MP0003656_abnormal_erythrocyte_physiolo | 0.77954218 |
| 111 | MP0001968_abnormal_touch/_nociception | 0.76851970 |
| 112 | MP0005395_other_phenotype | 0.76573671 |
| 113 | MP0002138_abnormal_hepatobiliary_system | 0.76413507 |
| 114 | MP0005332_abnormal_amino_acid | 0.76106154 |
| 115 | MP0002277_abnormal_respiratory_mucosa | 0.74998241 |
| 116 | MP0002419_abnormal_innate_immunity | 0.74929375 |
| 117 | MP0008260_abnormal_autophagy | 0.74665557 |
| 118 | MP0004147_increased_porphyrin_level | 0.74465982 |
| 119 | MP0001881_abnormal_mammary_gland | 0.71436922 |
| 120 | MP0005266_abnormal_metabolism | 0.70941018 |
| 121 | MP0009278_abnormal_bone_marrow | 0.70596236 |
| 122 | MP0004133_heterotaxia | 0.70454930 |
| 123 | MP0001905_abnormal_dopamine_level | 0.69992647 |
| 124 | MP0002161_abnormal_fertility/fecundity | 0.69943202 |
| 125 | MP0005670_abnormal_white_adipose | 0.69436227 |
| 126 | MP0002084_abnormal_developmental_patter | 0.68702368 |
| 127 | MP0003315_abnormal_perineum_morphology | 0.66943094 |
| 128 | MP0001845_abnormal_inflammatory_respons | 0.66697689 |
| 129 | MP0001727_abnormal_embryo_implantation | 0.65439040 |
| 130 | MP0010030_abnormal_orbit_morphology | 0.63042175 |
| 131 | MP0009672_abnormal_birth_weight | 0.61058139 |
| 132 | MP0005220_abnormal_exocrine_pancreas | 0.60241188 |
| 133 | MP0005319_abnormal_enzyme/_coenzyme | 0.56895790 |
| 134 | MP0001188_hyperpigmentation | 0.55901287 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.50567408 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.40235789 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 5.16191294 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.05857135 |
| 5 | Reticulocytopenia (HP:0001896) | 4.90492428 |
| 6 | Mitochondrial inheritance (HP:0001427) | 4.84081642 |
| 7 | Acute encephalopathy (HP:0006846) | 4.73306893 |
| 8 | Increased CSF lactate (HP:0002490) | 4.61476886 |
| 9 | Hepatic necrosis (HP:0002605) | 4.52995265 |
| 10 | Aplastic anemia (HP:0001915) | 4.18947798 |
| 11 | Birth length less than 3rd percentile (HP:0003561) | 4.16789362 |
| 12 | Progressive macrocephaly (HP:0004481) | 4.10584007 |
| 13 | Oral leukoplakia (HP:0002745) | 3.73095691 |
| 14 | Cerebral edema (HP:0002181) | 3.61917256 |
| 15 | Macrocytic anemia (HP:0001972) | 3.52744752 |
| 16 | Lactic acidosis (HP:0003128) | 3.50706491 |
| 17 | Increased hepatocellular lipid droplets (HP:0006565) | 3.45952960 |
| 18 | Pallor (HP:0000980) | 3.37251795 |
| 19 | Breast hypoplasia (HP:0003187) | 3.36447363 |
| 20 | Increased intramyocellular lipid droplets (HP:0012240) | 3.35430956 |
| 21 | Thrombocytosis (HP:0001894) | 3.25615926 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 3.17394410 |
| 23 | Respiratory failure (HP:0002878) | 3.10696174 |
| 24 | Chromsome breakage (HP:0040012) | 3.09966987 |
| 25 | Exercise intolerance (HP:0003546) | 3.09938804 |
| 26 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.07357249 |
| 27 | IgM deficiency (HP:0002850) | 2.98456712 |
| 28 | Absent thumb (HP:0009777) | 2.92064674 |
| 29 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.91952984 |
| 30 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.91952984 |
| 31 | Type I transferrin isoform profile (HP:0003642) | 2.91855569 |
| 32 | Abnormality of the preputium (HP:0100587) | 2.88338776 |
| 33 | Pancytopenia (HP:0001876) | 2.84403736 |
| 34 | Increased muscle lipid content (HP:0009058) | 2.83372091 |
| 35 | Renal Fanconi syndrome (HP:0001994) | 2.83176005 |
| 36 | 11 pairs of ribs (HP:0000878) | 2.82344829 |
| 37 | Carpal bone hypoplasia (HP:0001498) | 2.74744730 |
| 38 | Increased serum pyruvate (HP:0003542) | 2.73507745 |
| 39 | Selective tooth agenesis (HP:0001592) | 2.72890341 |
| 40 | Rough bone trabeculation (HP:0100670) | 2.72767433 |
| 41 | Abnormality of chromosome stability (HP:0003220) | 2.69987501 |
| 42 | Abnormality of the anterior horn cell (HP:0006802) | 2.68836940 |
| 43 | Degeneration of anterior horn cells (HP:0002398) | 2.68836940 |
| 44 | Testicular atrophy (HP:0000029) | 2.68282076 |
| 45 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.65764952 |
| 46 | Bone marrow hypocellularity (HP:0005528) | 2.64782491 |
| 47 | Meckel diverticulum (HP:0002245) | 2.64207517 |
| 48 | Microretrognathia (HP:0000308) | 2.62655027 |
| 49 | Abnormality of glycolysis (HP:0004366) | 2.62147477 |
| 50 | Myelodysplasia (HP:0002863) | 2.61663638 |
| 51 | Premature graying of hair (HP:0002216) | 2.57838786 |
| 52 | Abnormality of the ileum (HP:0001549) | 2.57714022 |
| 53 | Cerebral hypomyelination (HP:0006808) | 2.53626497 |
| 54 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.53378695 |
| 55 | Patellar aplasia (HP:0006443) | 2.52679979 |
| 56 | Methylmalonic aciduria (HP:0012120) | 2.48140237 |
| 57 | Reduced antithrombin III activity (HP:0001976) | 2.47226824 |
| 58 | Lethargy (HP:0001254) | 2.43857937 |
| 59 | CNS demyelination (HP:0007305) | 2.43510052 |
| 60 | Opisthotonus (HP:0002179) | 2.41793207 |
| 61 | Abnormal spermatogenesis (HP:0008669) | 2.41770313 |
| 62 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.41166221 |
| 63 | Progressive microcephaly (HP:0000253) | 2.40603993 |
| 64 | Colon cancer (HP:0003003) | 2.38583244 |
| 65 | Duplicated collecting system (HP:0000081) | 2.35710543 |
| 66 | Emotional lability (HP:0000712) | 2.32943003 |
| 67 | Leukodystrophy (HP:0002415) | 2.31334365 |
| 68 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.31205757 |
| 69 | Impulsivity (HP:0100710) | 2.31171774 |
| 70 | Recurrent bronchitis (HP:0002837) | 2.30152387 |
| 71 | Increased serum lactate (HP:0002151) | 2.29518762 |
| 72 | Lymphoma (HP:0002665) | 2.27858271 |
| 73 | Respiratory difficulties (HP:0002880) | 2.27746145 |
| 74 | Optic disc pallor (HP:0000543) | 2.26367502 |
| 75 | Dicarboxylic aciduria (HP:0003215) | 2.25253272 |
| 76 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.25253272 |
| 77 | Progressive muscle weakness (HP:0003323) | 2.20973608 |
| 78 | Multiple enchondromatosis (HP:0005701) | 2.20046230 |
| 79 | Agnosia (HP:0010524) | 2.19915369 |
| 80 | Acute lymphatic leukemia (HP:0006721) | 2.19392402 |
| 81 | Muscle fiber atrophy (HP:0100295) | 2.19275824 |
| 82 | Cellular immunodeficiency (HP:0005374) | 2.19227952 |
| 83 | Poikiloderma (HP:0001029) | 2.18899862 |
| 84 | Medulloblastoma (HP:0002885) | 2.17801950 |
| 85 | Hyperalaninemia (HP:0003348) | 2.16200528 |
| 86 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.16200528 |
| 87 | Abnormality of alanine metabolism (HP:0010916) | 2.16200528 |
| 88 | Abnormality of DNA repair (HP:0003254) | 2.15816095 |
| 89 | Trismus (HP:0000211) | 2.14418142 |
| 90 | Abnormal protein glycosylation (HP:0012346) | 2.14120646 |
| 91 | Abnormal glycosylation (HP:0012345) | 2.14120646 |
| 92 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.14120646 |
| 93 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.14120646 |
| 94 | Exertional dyspnea (HP:0002875) | 2.13546212 |
| 95 | Type 2 muscle fiber atrophy (HP:0003554) | 2.13396369 |
| 96 | Hyperglycinemia (HP:0002154) | 2.12994073 |
| 97 | Ragged-red muscle fibers (HP:0003200) | 2.12892602 |
| 98 | Petechiae (HP:0000967) | 2.11189902 |
| 99 | Abnormality of the renal collecting system (HP:0004742) | 2.10873225 |
| 100 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.10296503 |
| 101 | Abnormality of reticulocytes (HP:0004312) | 2.10226618 |
| 102 | Clubbing of toes (HP:0100760) | 2.06824976 |
| 103 | Abnormality of T cell physiology (HP:0011840) | 2.04807881 |
| 104 | Triphalangeal thumb (HP:0001199) | 2.04083030 |
| 105 | 3-Methylglutaconic aciduria (HP:0003535) | 2.03464235 |
| 106 | Methylmalonic acidemia (HP:0002912) | 2.02608167 |
| 107 | Premature ovarian failure (HP:0008209) | 2.02358714 |
| 108 | Duodenal stenosis (HP:0100867) | 2.01827273 |
| 109 | Small intestinal stenosis (HP:0012848) | 2.01827273 |
| 110 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.01063179 |
| 111 | Sloping forehead (HP:0000340) | 1.99648949 |
| 112 | Abnormality of serum amino acid levels (HP:0003112) | 1.98453828 |
| 113 | Hypoplasia of the radius (HP:0002984) | 1.98101170 |
| 114 | Neoplasm of the pancreas (HP:0002894) | 1.97951086 |
| 115 | Hypoplasia of the pons (HP:0012110) | 1.97948537 |
| 116 | Horseshoe kidney (HP:0000085) | 1.96969318 |
| 117 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.96733170 |
| 118 | Supernumerary spleens (HP:0009799) | 1.95898475 |
| 119 | Absent radius (HP:0003974) | 1.95372028 |
| 120 | Abnormal trabecular bone morphology (HP:0100671) | 1.94823954 |
| 121 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.93197867 |
| 122 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.92660917 |
| 123 | Panhypogammaglobulinemia (HP:0003139) | 1.91845959 |
| 124 | Tracheoesophageal fistula (HP:0002575) | 1.91507373 |
| 125 | Microvesicular hepatic steatosis (HP:0001414) | 1.90545483 |
| 126 | Nasal polyposis (HP:0100582) | 1.90509420 |
| 127 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.90313621 |
| 128 | Abnormality of methionine metabolism (HP:0010901) | 1.90160573 |
| 129 | Cleft eyelid (HP:0000625) | 1.89538385 |
| 130 | Pulmonary fibrosis (HP:0002206) | 1.88663650 |
| 131 | Sparse eyelashes (HP:0000653) | 1.86644968 |
| 132 | Squamous cell carcinoma (HP:0002860) | 1.86344625 |
| 133 | Death in infancy (HP:0001522) | 1.85805598 |
| 134 | Abnormality of the pons (HP:0007361) | 1.85790930 |
| 135 | Bronchitis (HP:0012387) | 1.85381534 |
| 136 | Hepatocellular necrosis (HP:0001404) | 1.84076249 |
| 137 | Secondary amenorrhea (HP:0000869) | 1.83033459 |
| 138 | Poor head control (HP:0002421) | 1.82248046 |
| 139 | Abnormality of T cells (HP:0002843) | 1.81811366 |
| 140 | Megaloblastic anemia (HP:0001889) | 1.81397193 |
| 141 | Asplenia (HP:0001746) | 1.80680796 |
| 142 | Gliosis (HP:0002171) | 1.80334721 |
| 143 | Hyperglycinuria (HP:0003108) | 1.79853629 |
| 144 | Chronic otitis media (HP:0000389) | 1.79838979 |
| 145 | Leukopenia (HP:0001882) | 1.79180555 |
| 146 | Neoplasm of the adrenal gland (HP:0100631) | 1.78191094 |
| 147 | Generalized aminoaciduria (HP:0002909) | 1.78127280 |
| 148 | B lymphocytopenia (HP:0010976) | 1.78017379 |
| 149 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.77387723 |
| 150 | CNS hypomyelination (HP:0003429) | 1.74539765 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.71715779 |
| 2 | BUB1 | 4.13671745 |
| 3 | WEE1 | 3.89895016 |
| 4 | NME2 | 2.91692746 |
| 5 | STK16 | 2.80686216 |
| 6 | CDC7 | 2.80322188 |
| 7 | TESK2 | 2.51781034 |
| 8 | EIF2AK1 | 2.44088848 |
| 9 | NEK2 | 2.37647322 |
| 10 | PIM2 | 2.25259189 |
| 11 | SRPK1 | 2.14929399 |
| 12 | VRK1 | 2.14732778 |
| 13 | MAP4K1 | 2.10426400 |
| 14 | PLK4 | 2.10120818 |
| 15 | NUAK1 | 2.07111468 |
| 16 | ACVR1B | 1.93903798 |
| 17 | EIF2AK3 | 1.93613735 |
| 18 | NME1 | 1.85007975 |
| 19 | BCKDK | 1.83553774 |
| 20 | BRSK2 | 1.81847663 |
| 21 | TLK1 | 1.81716688 |
| 22 | TESK1 | 1.77160735 |
| 23 | PASK | 1.75160094 |
| 24 | MST4 | 1.71058038 |
| 25 | DYRK3 | 1.69017418 |
| 26 | TTK | 1.65248423 |
| 27 | CDK7 | 1.64819986 |
| 28 | ATR | 1.64594604 |
| 29 | PLK1 | 1.59955267 |
| 30 | RPS6KB2 | 1.58038798 |
| 31 | TSSK6 | 1.56925496 |
| 32 | TRIM28 | 1.49327463 |
| 33 | TAF1 | 1.47758652 |
| 34 | FLT3 | 1.46909850 |
| 35 | MAP4K2 | 1.35559751 |
| 36 | IRAK3 | 1.34374498 |
| 37 | AURKB | 1.28814845 |
| 38 | EEF2K | 1.27940786 |
| 39 | MAPKAPK3 | 1.19937196 |
| 40 | PIM1 | 1.19837455 |
| 41 | KDR | 1.19791206 |
| 42 | CSNK1G3 | 1.19156027 |
| 43 | BRSK1 | 1.18387110 |
| 44 | IRAK4 | 1.15116529 |
| 45 | MKNK1 | 1.14964702 |
| 46 | CCNB1 | 1.14458267 |
| 47 | ZAK | 1.13667202 |
| 48 | RPS6KA4 | 1.11320269 |
| 49 | NEK1 | 1.10493849 |
| 50 | CHEK2 | 1.10374331 |
| 51 | MAP3K11 | 1.07727227 |
| 52 | CDK4 | 1.07538785 |
| 53 | KIT | 1.06156826 |
| 54 | TEC | 1.04367125 |
| 55 | PDK4 | 1.03490827 |
| 56 | PDK3 | 1.03490827 |
| 57 | BTK | 1.03054057 |
| 58 | TGFBR1 | 1.02600162 |
| 59 | AURKA | 1.00952192 |
| 60 | SMG1 | 0.95928999 |
| 61 | SCYL2 | 0.95618966 |
| 62 | PAK4 | 0.93891035 |
| 63 | CSNK1G1 | 0.92845170 |
| 64 | MAP3K8 | 0.91174300 |
| 65 | STK10 | 0.90664302 |
| 66 | CSNK1A1L | 0.90202419 |
| 67 | EPHA2 | 0.87246059 |
| 68 | CDK8 | 0.86253002 |
| 69 | STK4 | 0.85100669 |
| 70 | CHEK1 | 0.84942184 |
| 71 | MAP2K3 | 0.83605282 |
| 72 | CSNK1G2 | 0.83093046 |
| 73 | MKNK2 | 0.83023299 |
| 74 | DYRK2 | 0.82977210 |
| 75 | ZAP70 | 0.80926331 |
| 76 | BLK | 0.80260627 |
| 77 | ARAF | 0.78990182 |
| 78 | TYK2 | 0.77637837 |
| 79 | TXK | 0.77389380 |
| 80 | BMPR1B | 0.75023923 |
| 81 | CSF1R | 0.74802771 |
| 82 | ABL2 | 0.73388087 |
| 83 | PLK3 | 0.72500009 |
| 84 | CSNK2A2 | 0.71994712 |
| 85 | CSNK2A1 | 0.71869319 |
| 86 | BRAF | 0.64908920 |
| 87 | WNK3 | 0.64813583 |
| 88 | MAP3K10 | 0.63751595 |
| 89 | EIF2AK2 | 0.63027828 |
| 90 | MAPKAPK5 | 0.62568765 |
| 91 | CLK1 | 0.62232249 |
| 92 | DAPK3 | 0.62082837 |
| 93 | PDK2 | 0.62002709 |
| 94 | PAK1 | 0.60383060 |
| 95 | IKBKB | 0.59397550 |
| 96 | RPS6KA5 | 0.59248909 |
| 97 | GRK6 | 0.59192318 |
| 98 | ATM | 0.57989564 |
| 99 | CDK2 | 0.57080982 |
| 100 | LRRK2 | 0.56080762 |
| 101 | JAK3 | 0.55397102 |
| 102 | PRKCI | 0.55023845 |
| 103 | LIMK1 | 0.51169487 |
| 104 | TAOK2 | 0.50857527 |
| 105 | MAPK11 | 0.50690110 |
| 106 | PKN2 | 0.43932352 |
| 107 | LYN | 0.42939375 |
| 108 | CDK12 | 0.42876203 |
| 109 | SYK | 0.41491699 |
| 110 | CDK19 | 0.41364591 |
| 111 | ERN1 | 0.38587384 |
| 112 | ALK | 0.38122918 |
| 113 | MUSK | 0.36759159 |
| 114 | GRK1 | 0.36437043 |
| 115 | MATK | 0.35536372 |
| 116 | TBK1 | 0.35018982 |
| 117 | IKBKE | 0.34682043 |
| 118 | AKT2 | 0.34476158 |
| 119 | TAOK3 | 0.34324679 |
| 120 | CDK9 | 0.32535226 |
| 121 | DAPK1 | 0.31835958 |
| 122 | CDK1 | 0.31339210 |
| 123 | YES1 | 0.31004967 |
| 124 | RPS6KA6 | 0.30809790 |
| 125 | MAP2K2 | 0.30039429 |
| 126 | MAP2K6 | 0.29018023 |
| 127 | PBK | 0.28625685 |
| 128 | SIK3 | 0.26257762 |
| 129 | CSNK1A1 | 0.23995751 |
| 130 | GRK5 | 0.23080447 |
| 131 | TNK2 | 0.20256860 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.97315315 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.16462880 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 4.01620930 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.19899432 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.15455580 |
| 6 | Proteasome_Homo sapiens_hsa03050 | 3.13369533 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 3.08776631 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 3.01650668 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.91018134 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.70232145 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.67188704 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.46364840 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.45295809 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.20717914 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.18962002 |
| 16 | Cell cycle_Homo sapiens_hsa04110 | 1.93688586 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.86630784 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.77129098 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.62147313 |
| 20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.57920596 |
| 21 | * RNA degradation_Homo sapiens_hsa03018 | 1.54631979 |
| 22 | Purine metabolism_Homo sapiens_hsa00230 | 1.44629823 |
| 23 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.43323092 |
| 24 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.40469861 |
| 25 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.36444393 |
| 26 | Sulfur relay system_Homo sapiens_hsa04122 | 1.29646233 |
| 27 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.26244326 |
| 28 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.21441885 |
| 29 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.18715715 |
| 30 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.17348989 |
| 31 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.16846696 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.14169344 |
| 33 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.10205837 |
| 34 | Protein export_Homo sapiens_hsa03060 | 1.08410296 |
| 35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.05280329 |
| 36 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.03464560 |
| 37 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.03001962 |
| 38 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.98572369 |
| 39 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.98228906 |
| 40 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.94643731 |
| 41 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.94566426 |
| 42 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.93269734 |
| 43 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.91722499 |
| 44 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.91026367 |
| 45 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.90898133 |
| 46 | Asthma_Homo sapiens_hsa05310 | 0.88029523 |
| 47 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.84463875 |
| 48 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.80681023 |
| 49 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.80249825 |
| 50 | Huntingtons disease_Homo sapiens_hsa05016 | 0.77118218 |
| 51 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.76988623 |
| 52 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.74740170 |
| 53 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.74597744 |
| 54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.74141681 |
| 55 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.73934310 |
| 56 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.73841856 |
| 57 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.73767802 |
| 58 | Parkinsons disease_Homo sapiens_hsa05012 | 0.67608304 |
| 59 | Carbon metabolism_Homo sapiens_hsa01200 | 0.64155958 |
| 60 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.63848427 |
| 61 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.62451109 |
| 62 | Legionellosis_Homo sapiens_hsa05134 | 0.62225335 |
| 63 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.61685730 |
| 64 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.60829848 |
| 65 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.53731647 |
| 66 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.53661489 |
| 67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.52161805 |
| 68 | Measles_Homo sapiens_hsa05162 | 0.48925633 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48151419 |
| 70 | Other glycan degradation_Homo sapiens_hsa00511 | 0.46580618 |
| 71 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.45786683 |
| 72 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.45730227 |
| 73 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.44545015 |
| 74 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.44270371 |
| 75 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.44090712 |
| 76 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.42238444 |
| 77 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41303336 |
| 78 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.41086123 |
| 79 | HTLV-I infection_Homo sapiens_hsa05166 | 0.40941166 |
| 80 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.39769389 |
| 81 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.38005227 |
| 82 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.36931717 |
| 83 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.36891738 |
| 84 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.36596399 |
| 85 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.34936639 |
| 86 | Apoptosis_Homo sapiens_hsa04210 | 0.34879506 |
| 87 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.34782912 |
| 88 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.34395817 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34275480 |
| 90 | Thyroid cancer_Homo sapiens_hsa05216 | 0.33770960 |
| 91 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.33681119 |
| 92 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33210121 |
| 93 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.33191214 |
| 94 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.32968372 |
| 95 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.32311756 |
| 96 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30984300 |
| 97 | Viral myocarditis_Homo sapiens_hsa05416 | 0.30354297 |
| 98 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.29367824 |
| 99 | Phototransduction_Homo sapiens_hsa04744 | 0.27987811 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.26870483 |
| 101 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.26156256 |
| 102 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.25759013 |
| 103 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.25510383 |
| 104 | Influenza A_Homo sapiens_hsa05164 | 0.24876129 |
| 105 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.24569246 |
| 106 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.24435498 |
| 107 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.23661120 |
| 108 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.23465138 |
| 109 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.23270126 |
| 110 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.22635727 |
| 111 | Alcoholism_Homo sapiens_hsa05034 | 0.22271422 |
| 112 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.21625609 |
| 113 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.21028166 |
| 114 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.20982355 |
| 115 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.20139370 |
| 116 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.19223310 |
| 117 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.18910125 |
| 118 | Shigellosis_Homo sapiens_hsa05131 | 0.18829637 |
| 119 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.17467266 |
| 120 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.16645638 |
| 121 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.15830896 |
| 122 | Peroxisome_Homo sapiens_hsa04146 | 0.15551409 |
| 123 | Leishmaniasis_Homo sapiens_hsa05140 | 0.15435549 |
| 124 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.15181052 |
| 125 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.14842148 |
| 126 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.14428923 |
| 127 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.13709745 |
| 128 | Hepatitis B_Homo sapiens_hsa05161 | 0.13576390 |
| 129 | Allograft rejection_Homo sapiens_hsa05330 | 0.13146053 |
| 130 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.12930773 |

