EXOSC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.86270956
2viral transcription (GO:0019083)7.29299336
3translational termination (GO:0006415)7.07879045
4ribosomal small subunit biogenesis (GO:0042274)6.51011953
5* DNA deamination (GO:0045006)6.45947130
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.20962625
7translational elongation (GO:0006414)6.14359520
8cotranslational protein targeting to membrane (GO:0006613)6.08660922
9protein targeting to ER (GO:0045047)6.05493646
10maturation of SSU-rRNA (GO:0030490)5.91289032
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.75981339
12protein localization to endoplasmic reticulum (GO:0070972)5.74343139
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.43905226
14viral life cycle (GO:0019058)5.43679932
15cellular protein complex disassembly (GO:0043624)5.41440487
16telomere maintenance via semi-conservative replication (GO:0032201)5.38800267
17ribosomal large subunit biogenesis (GO:0042273)5.29491424
18translational initiation (GO:0006413)5.24336000
19DNA strand elongation involved in DNA replication (GO:0006271)5.10594441
20pseudouridine synthesis (GO:0001522)4.97666564
21DNA strand elongation (GO:0022616)4.87361935
22protein complex disassembly (GO:0043241)4.76320295
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.67185058
24telomere maintenance via recombination (GO:0000722)4.50885414
25macromolecular complex disassembly (GO:0032984)4.50874823
26DNA replication initiation (GO:0006270)4.48789022
27ribonucleoprotein complex biogenesis (GO:0022613)4.44314936
28behavioral response to nicotine (GO:0035095)4.42871954
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.32147721
30translation (GO:0006412)4.24195346
31proteasome assembly (GO:0043248)4.22915877
32* nuclear-transcribed mRNA catabolic process (GO:0000956)4.09989737
33DNA replication checkpoint (GO:0000076)4.06363433
34mitotic recombination (GO:0006312)4.01717521
35water-soluble vitamin biosynthetic process (GO:0042364)3.98604605
36protein targeting to membrane (GO:0006612)3.97743016
37telomere maintenance via telomere lengthening (GO:0010833)3.95497624
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.91282054
39termination of RNA polymerase III transcription (GO:0006386)3.91282054
40* rRNA processing (GO:0006364)3.89125111
41* mRNA catabolic process (GO:0006402)3.88883336
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.81712147
43CENP-A containing nucleosome assembly (GO:0034080)3.80773125
44chromatin remodeling at centromere (GO:0031055)3.80497387
45* rRNA metabolic process (GO:0016072)3.75410541
46cellular component biogenesis (GO:0044085)3.68982950
47* RNA catabolic process (GO:0006401)3.67725531
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.63098900
49pyrimidine nucleotide catabolic process (GO:0006244)3.59947372
50establishment of integrated proviral latency (GO:0075713)3.53724292
51L-fucose catabolic process (GO:0042355)3.53565677
52fucose catabolic process (GO:0019317)3.53565677
53L-fucose metabolic process (GO:0042354)3.53565677
54DNA unwinding involved in DNA replication (GO:0006268)3.45702158
55spliceosomal snRNP assembly (GO:0000387)3.43920669
56formation of translation preinitiation complex (GO:0001731)3.42776132
57kinetochore assembly (GO:0051382)3.37468090
58ribosome biogenesis (GO:0042254)3.34946749
59protein K11-linked deubiquitination (GO:0035871)3.33800479
60respiratory chain complex IV assembly (GO:0008535)3.31678960
61nucleobase biosynthetic process (GO:0046112)3.30514742
62keratinocyte development (GO:0003334)3.28031212
63* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26517158
64kinetochore organization (GO:0051383)3.25749361
65regulation of nuclear cell cycle DNA replication (GO:0033262)3.22091812
66pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.21070970
67negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20768363
68negative regulation of translation, ncRNA-mediated (GO:0040033)3.20768363
69regulation of translation, ncRNA-mediated (GO:0045974)3.20768363
70platelet dense granule organization (GO:0060155)3.20407414
71DNA replication-independent nucleosome assembly (GO:0006336)3.19659148
72DNA replication-independent nucleosome organization (GO:0034724)3.19659148
73transcription-coupled nucleotide-excision repair (GO:0006283)3.17471183
74regulation of mitochondrial translation (GO:0070129)3.16914943
75cellular ketone body metabolic process (GO:0046950)3.15872883
76spliceosomal complex assembly (GO:0000245)3.15222598
77protein K6-linked ubiquitination (GO:0085020)3.15202928
78preassembly of GPI anchor in ER membrane (GO:0016254)3.14814748
79tryptophan catabolic process (GO:0006569)3.12460611
80indole-containing compound catabolic process (GO:0042436)3.12460611
81indolalkylamine catabolic process (GO:0046218)3.12460611
82cellular response to ATP (GO:0071318)3.12285506
83mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12061971
84* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11379965
85purine nucleobase biosynthetic process (GO:0009113)3.09691064
86rRNA modification (GO:0000154)3.09188645
87indolalkylamine metabolic process (GO:0006586)3.08452050
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07411028
89replication fork processing (GO:0031297)3.04057600
90histone mRNA metabolic process (GO:0008334)3.03680179
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01681242
92ketone body metabolic process (GO:1902224)3.00650334
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99861524
94deoxyribose phosphate biosynthetic process (GO:0046385)2.97750468
952-deoxyribonucleotide biosynthetic process (GO:0009265)2.97750468
96gamma-aminobutyric acid transport (GO:0015812)2.97309612
97response to pheromone (GO:0019236)2.95320143
98signal peptide processing (GO:0006465)2.94724747
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94679864
100energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94188200
101ATP synthesis coupled proton transport (GO:0015986)2.94188200
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92813392
103membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92151434
104cornea development in camera-type eye (GO:0061303)2.92111067
105detection of light stimulus involved in sensory perception (GO:0050962)2.90752432
106detection of light stimulus involved in visual perception (GO:0050908)2.90752432
107oxidative phosphorylation (GO:0006119)2.89683126
108regulation of hexokinase activity (GO:1903299)2.89474236
109regulation of glucokinase activity (GO:0033131)2.89474236
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.89443417
111kynurenine metabolic process (GO:0070189)2.89150735
112deoxyribonucleotide catabolic process (GO:0009264)2.88438048
113double-strand break repair via homologous recombination (GO:0000724)2.87552074
114startle response (GO:0001964)2.87013750
115recombinational repair (GO:0000725)2.85805646
116sulfation (GO:0051923)2.84001026
117* ncRNA processing (GO:0034470)2.83370286
118prostate gland growth (GO:0060736)2.82981494
119protein complex biogenesis (GO:0070271)2.82047940
120protein targeting to mitochondrion (GO:0006626)2.80143738
121tryptophan metabolic process (GO:0006568)2.80092518
122establishment of viral latency (GO:0019043)2.79668476
123reflex (GO:0060004)2.79351946
124negative regulation of ligase activity (GO:0051352)2.78517171
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78517171
126GTP biosynthetic process (GO:0006183)2.78244078
127protein prenylation (GO:0018342)2.77755382
128prenylation (GO:0097354)2.77755382
129metallo-sulfur cluster assembly (GO:0031163)2.77600990
130iron-sulfur cluster assembly (GO:0016226)2.77600990
131regulation of hippo signaling (GO:0035330)2.77252292
132pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76911883
133negative regulation of RNA splicing (GO:0033119)2.76534974
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76443431
135establishment of protein localization to membrane (GO:0090150)2.75684267
136histone exchange (GO:0043486)2.75577363
137synapsis (GO:0007129)2.75102115
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74565989
139protein targeting (GO:0006605)2.73346124
140termination of RNA polymerase II transcription (GO:0006369)2.72751953
141kidney morphogenesis (GO:0060993)2.72572069
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72077210
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.72077210
144NADH dehydrogenase complex assembly (GO:0010257)2.72077210
145negative regulation of telomere maintenance (GO:0032205)2.71813614
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70439900
147chaperone-mediated protein transport (GO:0072321)2.70424843
148regulation of energy homeostasis (GO:2000505)2.69874759
149cytochrome complex assembly (GO:0017004)2.68965227
150deoxyribonucleotide biosynthetic process (GO:0009263)2.68953914
151regulation of telomere maintenance (GO:0032204)2.68475784
152mitochondrial respiratory chain complex assembly (GO:0033108)2.68067884
153serotonin metabolic process (GO:0042428)2.67380819
154inositol phosphate catabolic process (GO:0071545)2.67266045
155mannosylation (GO:0097502)2.65637530
156purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.65609691
1573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.65609691
158peristalsis (GO:0030432)2.65103085
159regulation of DNA endoreduplication (GO:0032875)2.61655972
160replicative senescence (GO:0090399)2.61234542
161indole-containing compound metabolic process (GO:0042430)2.59926682
162reciprocal meiotic recombination (GO:0007131)2.58549603
163reciprocal DNA recombination (GO:0035825)2.58549603
164regulation of action potential (GO:0098900)2.58373197
165neuronal action potential (GO:0019228)2.57254528
166regulation of neurotransmitter uptake (GO:0051580)2.55496554
167spinal cord motor neuron differentiation (GO:0021522)2.54334857
168positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.52783377
169negative regulation of cell aging (GO:0090344)2.52600276
170neural tube formation (GO:0001841)2.50905069
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50719855
172primary amino compound metabolic process (GO:1901160)2.49929338
173regulation of cell proliferation involved in kidney development (GO:1901722)2.45440142
174meiotic chromosome segregation (GO:0045132)2.45031266
175negative regulation of Rho protein signal transduction (GO:0035024)2.40963544
176photoreceptor cell development (GO:0042461)2.38882829
177protein polyglutamylation (GO:0018095)2.37056189
178RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.36856825
179negative regulation of mast cell activation (GO:0033004)2.36364712
180proline transport (GO:0015824)2.35093374
181atrial cardiac muscle cell action potential (GO:0086014)2.34640859
182presynaptic membrane assembly (GO:0097105)2.34488579
183maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.32758161
184regulation of mesoderm development (GO:2000380)2.32702489
185positive regulation of developmental pigmentation (GO:0048087)2.32210790
186piRNA metabolic process (GO:0034587)2.31772226
187positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.31391051
188negative regulation of reactive oxygen species metabolic process (GO:2000378)2.31321131
189estrogen biosynthetic process (GO:0006703)2.31319768
190polyol catabolic process (GO:0046174)2.29680377
191phasic smooth muscle contraction (GO:0014821)2.28927469
192positive regulation of oligodendrocyte differentiation (GO:0048714)2.28874143
193dentate gyrus development (GO:0021542)2.27509050
194eye photoreceptor cell development (GO:0042462)2.27504787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02925557
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.09399941
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.74666727
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.33601155
5ZNF274_21170338_ChIP-Seq_K562_Hela3.50237042
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.39002094
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33466724
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.25474055
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24391010
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.17352875
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.14294268
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.10296025
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05453175
14GBX2_23144817_ChIP-Seq_PC3_Human2.98568685
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91214270
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89956289
17VDR_22108803_ChIP-Seq_LS180_Human2.80099570
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79101346
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70333683
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.65371210
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64059150
22* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.58787018
23IGF1R_20145208_ChIP-Seq_DFB_Human2.57622800
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57271106
25XRN2_22483619_ChIP-Seq_HELA_Human2.54683482
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54296665
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54003272
28EWS_26573619_Chip-Seq_HEK293_Human2.48662931
29VDR_23849224_ChIP-Seq_CD4+_Human2.46546241
30FUS_26573619_Chip-Seq_HEK293_Human2.39417282
31* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38712178
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38648528
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.36340651
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35431941
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34728744
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32663819
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23130665
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22736661
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20619827
40DCP1A_22483619_ChIP-Seq_HELA_Human2.18931257
41TAF15_26573619_Chip-Seq_HEK293_Human2.15416020
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12207898
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08795807
44FOXP3_21729870_ChIP-Seq_TREG_Human2.06018420
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.05177716
46CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04194444
47NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02239087
48TTF2_22483619_ChIP-Seq_HELA_Human1.97696430
49GABP_19822575_ChIP-Seq_HepG2_Human1.94724339
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.94094695
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92745925
52P300_19829295_ChIP-Seq_ESCs_Human1.89168496
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.88451965
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.86316917
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84539541
56ER_23166858_ChIP-Seq_MCF-7_Human1.84042285
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81312630
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80858602
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.80125594
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78629637
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78079274
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.77146530
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72761274
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71793699
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.71534658
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71363896
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71071513
68CIITA_25753668_ChIP-Seq_RAJI_Human1.65029687
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.64483822
70* VDR_21846776_ChIP-Seq_THP-1_Human1.61130071
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60600819
72SCL_19346495_ChIP-Seq_HPC-7_Human1.60107174
73AR_21909140_ChIP-Seq_LNCAP_Human1.58465356
74BCAT_22108803_ChIP-Seq_LS180_Human1.57989615
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55336297
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54301916
77MYC_22102868_ChIP-Seq_BL_Human1.53750406
78EZH2_22144423_ChIP-Seq_EOC_Human1.52501556
79STAT3_23295773_ChIP-Seq_U87_Human1.52259742
80ELK1_19687146_ChIP-ChIP_HELA_Human1.51588923
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50486872
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49602971
83REST_21632747_ChIP-Seq_MESCs_Mouse1.47829513
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46863192
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46261516
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45078639
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44527879
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44417737
89IRF1_19129219_ChIP-ChIP_H3396_Human1.41728340
90RNF2_27304074_Chip-Seq_NSC_Mouse1.41295236
91TP53_22573176_ChIP-Seq_HFKS_Human1.40388142
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39899210
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39294771
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39039650
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.38626807
96TCF4_23295773_ChIP-Seq_U87_Human1.38338873
97SPI1_23547873_ChIP-Seq_NB4_Human1.38172273
98SMAD4_21799915_ChIP-Seq_A2780_Human1.38094478
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37510778
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.37026662
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35198908
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34843307
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34117385
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32968952
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32968952
106CBP_20019798_ChIP-Seq_JUKART_Human1.32089691
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32089691
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30794433
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29998449
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27951154
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26905799
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.25851544
113AR_25329375_ChIP-Seq_VCAP_Human1.24292658
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24289529
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24111157
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23155057
117MYC_18940864_ChIP-ChIP_HL60_Human1.22698346
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22377767
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21265701
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21190906
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20220864
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19502951
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17261858
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.15933942
125TP63_19390658_ChIP-ChIP_HaCaT_Human1.13285993
126SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12119272
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12038700
128* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11978578
129TCF4_22108803_ChIP-Seq_LS180_Human1.11142124
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10924440
131SOX2_19829295_ChIP-Seq_ESCs_Human1.10848235
132NANOG_19829295_ChIP-Seq_ESCs_Human1.10848235
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10754958
134KDM5A_27292631_Chip-Seq_BREAST_Human1.10617500
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09547877
136YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09379787
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.08579508
138NFE2_27457419_Chip-Seq_LIVER_Mouse1.08165787
139KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08004698
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07834627
141PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07769032
142ELK1_22589737_ChIP-Seq_MCF10A_Human1.07393218
143EZH2_27294783_Chip-Seq_NPCs_Mouse1.07110259
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.07083999
145FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07083999
146* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06507902
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05787086
148* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04435314
149SMAD4_21741376_ChIP-Seq_EPCs_Human1.03680162
150NCOR_22424771_ChIP-Seq_293T_Human1.03429853
151* VDR_24763502_ChIP-Seq_THP-1_Human1.02057150
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01530155
153GATA3_21878914_ChIP-Seq_MCF-7_Human1.01225339
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00999303
155HOXB7_26014856_ChIP-Seq_BT474_Human1.00919614
156AR_21572438_ChIP-Seq_LNCaP_Human1.00445112
157TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00415700
158NANOG_18555785_Chip-Seq_ESCs_Mouse1.00251010
159RUNX2_22187159_ChIP-Seq_PCA_Human1.00039330
160* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99831411
161BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97098444
162STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96279008
163AHR_22903824_ChIP-Seq_MCF-7_Human0.95859500
164KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95846315
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.95620627
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95370233
167TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95132860
168P53_22387025_ChIP-Seq_ESCs_Mouse0.92559414
169CRX_20693478_ChIP-Seq_RETINA_Mouse0.92277800
170JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91232814
171FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90995772
172RUNX1_22412390_ChIP-Seq_EML_Mouse0.89790812
173BP1_19119308_ChIP-ChIP_Hs578T_Human0.89198452
174REST_18959480_ChIP-ChIP_MESCs_Mouse0.89152249
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88836219
176KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88562578
177CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87222406
178LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86728664
179TFEB_21752829_ChIP-Seq_HELA_Human0.83496807
180TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82394738
181MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81944113
182EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81454590
183ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81216448
184* MAF_26560356_Chip-Seq_TH2_Human0.80301493
185STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79301097
186* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79082514
187UTX_26944678_Chip-Seq_JUKART_Human0.78901879
188EGR1_19374776_ChIP-ChIP_THP-1_Human0.78390417
189IRF8_22096565_ChIP-ChIP_GC-B_Human0.78310627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.90752318
2MP0003693_abnormal_embryo_hatching4.70935366
3MP0004957_abnormal_blastocyst_morpholog3.76374078
4MP0002396_abnormal_hematopoietic_system3.68042182
5MP0008057_abnormal_DNA_replication3.43894865
6MP0010094_abnormal_chromosome_stability3.34937707
7MP0008058_abnormal_DNA_repair3.03844734
8MP0003111_abnormal_nucleus_morphology2.98496561
9MP0003077_abnormal_cell_cycle2.88818583
10MP0008007_abnormal_cellular_replicative2.84631428
11MP0005174_abnormal_tail_pigmentation2.61748420
12MP0000490_abnormal_crypts_of2.54215456
13MP0000569_abnormal_digit_pigmentation2.52665471
14MP0009046_muscle_twitch2.49302900
15MP0002102_abnormal_ear_morphology2.48381594
16MP0003195_calcinosis2.38835893
17MP0003763_abnormal_thymus_physiology2.36937829
18MP0003787_abnormal_imprinting2.32037405
19MP0005397_hematopoietic_system_phenotyp2.18843145
20MP0001545_abnormal_hematopoietic_system2.18843145
21MP0002876_abnormal_thyroid_physiology2.18565867
22MP0005075_abnormal_melanosome_morpholog2.16457445
23MP0002837_dystrophic_cardiac_calcinosis2.13378032
24MP0002160_abnormal_reproductive_system2.11288011
25MP0003786_premature_aging2.01828721
26MP0005645_abnormal_hypothalamus_physiol1.97570705
27MP0006292_abnormal_olfactory_placode1.96739023
28MP0009333_abnormal_splenocyte_physiolog1.95581561
29MP0001968_abnormal_touch/_nociception1.94111885
30MP0005551_abnormal_eye_electrophysiolog1.90663308
31MP0005671_abnormal_response_to1.88107470
32MP0005646_abnormal_pituitary_gland1.81745261
33MP0001485_abnormal_pinna_reflex1.81138605
34MP0001853_heart_inflammation1.80847707
35MP0000427_abnormal_hair_cycle1.80657506
36MP0009745_abnormal_behavioral_response1.80375069
37MP0004147_increased_porphyrin_level1.77335570
38MP0004808_abnormal_hematopoietic_stem1.76061182
39MP0008932_abnormal_embryonic_tissue1.75445260
40MP0002095_abnormal_skin_pigmentation1.74198588
41MP0000685_abnormal_immune_system1.70934359
42MP0002398_abnormal_bone_marrow1.70296925
43MP0000631_abnormal_neuroendocrine_gland1.70198253
44MP0001835_abnormal_antigen_presentation1.69211320
45MP0004043_abnormal_pH_regulation1.67542607
46MP0003880_abnormal_central_pattern1.66640840
47MP0003186_abnormal_redox_activity1.66046082
48MP0005389_reproductive_system_phenotype1.64771249
49MP0002132_abnormal_respiratory_system1.62424085
50MP0008872_abnormal_physiological_respon1.61401404
51MP0006054_spinal_hemorrhage1.58946346
52MP0003283_abnormal_digestive_organ1.58472089
53MP0002166_altered_tumor_susceptibility1.57611445
54MP0003646_muscle_fatigue1.57042936
55MP0006072_abnormal_retinal_apoptosis1.56131312
56MP0009785_altered_susceptibility_to1.56118331
57MP0000516_abnormal_urinary_system1.55769946
58MP0005367_renal/urinary_system_phenotyp1.55769946
59MP0006036_abnormal_mitochondrial_physio1.51398308
60MP0005253_abnormal_eye_physiology1.50453225
61MP0002272_abnormal_nervous_system1.49829512
62MP0002722_abnormal_immune_system1.49682306
63MP0000689_abnormal_spleen_morphology1.47028942
64MP0004885_abnormal_endolymph1.45107055
65MP0002019_abnormal_tumor_incidence1.41839467
66MP0002006_tumorigenesis1.41764748
67MP0000313_abnormal_cell_death1.41684079
68MP0005025_abnormal_response_to1.40996936
69MP0004142_abnormal_muscle_tone1.39875082
70MP0004133_heterotaxia1.39777830
71MP0002064_seizures1.39163861
72MP0002429_abnormal_blood_cell1.38823572
73MP0000465_gastrointestinal_hemorrhage1.37416934
74MP0001188_hyperpigmentation1.37203705
75MP0000716_abnormal_immune_system1.35291017
76MP0003890_abnormal_embryonic-extraembry1.35095257
77MP0003123_paternal_imprinting1.34905804
78MP0000703_abnormal_thymus_morphology1.32082700
79MP0003315_abnormal_perineum_morphology1.32006213
80MP0000350_abnormal_cell_proliferation1.31875072
81MP0002736_abnormal_nociception_after1.31434161
82MP0002420_abnormal_adaptive_immunity1.28501587
83MP0001944_abnormal_pancreas_morphology1.28372622
84MP0002928_abnormal_bile_duct1.27815037
85MP0002572_abnormal_emotion/affect_behav1.26864190
86MP0001501_abnormal_sleep_pattern1.26853942
87MP0005386_behavior/neurological_phenoty1.26763433
88MP0004924_abnormal_behavior1.26763433
89MP0003635_abnormal_synaptic_transmissio1.26761714
90MP0003724_increased_susceptibility_to1.25792001
91MP0005171_absent_coat_pigmentation1.25542871
92MP0001819_abnormal_immune_cell1.25217566
93MP0010155_abnormal_intestine_physiology1.22716519
94MP0005379_endocrine/exocrine_gland_phen1.21153794
95MP0002909_abnormal_adrenal_gland1.16105393
96MP0002735_abnormal_chemical_nociception1.15468541
97MP0003866_abnormal_defecation1.13485770
98MP0002148_abnormal_hypersensitivity_rea1.12999111
99MP0001486_abnormal_startle_reflex1.12938846
100MP0002557_abnormal_social/conspecific_i1.12378677
101MP0001873_stomach_inflammation1.12371697
102MP0000383_abnormal_hair_follicle1.12184121
103MP0005423_abnormal_somatic_nervous1.12013267
104MP0005220_abnormal_exocrine_pancreas1.11592067
105MP0003436_decreased_susceptibility_to1.11533094
106MP0005000_abnormal_immune_tolerance1.10488746
107MP0003656_abnormal_erythrocyte_physiolo1.10353838
108MP0006276_abnormal_autonomic_nervous1.10275078
109MP0001529_abnormal_vocalization1.09985457
110MP0001919_abnormal_reproductive_system1.09946882
111MP0003136_yellow_coat_color1.09356332
112MP0002063_abnormal_learning/memory/cond1.09189535
113MP0000015_abnormal_ear_pigmentation1.09061552
114MP0002723_abnormal_immune_serum1.08773637
115MP0005464_abnormal_platelet_physiology1.08126869
116MP0000013_abnormal_adipose_tissue1.05066418
117MP0002938_white_spotting1.03358327
118MP0001800_abnormal_humoral_immune1.03204611
119MP0008875_abnormal_xenobiotic_pharmacok1.02747530
120MP0000613_abnormal_salivary_gland1.02307767
121MP0002693_abnormal_pancreas_physiology1.01952432
122MP0002638_abnormal_pupillary_reflex1.01871003
123MP0002452_abnormal_antigen_presenting1.01772455
124MP0001293_anophthalmia1.01435243
125MP0000858_altered_metastatic_potential1.01384780
126MP0001661_extended_life_span1.01063947
127MP0003121_genomic_imprinting0.99947874
128MP0001970_abnormal_pain_threshold0.99853295
129MP0008877_abnormal_DNA_methylation0.99651350
130MP0001984_abnormal_olfaction0.99300220
131MP0000778_abnormal_nervous_system0.97987199
132MP0001730_embryonic_growth_arrest0.97706158
133MP0002653_abnormal_ependyma_morphology0.97095464
134MP0002751_abnormal_autonomic_nervous0.96032865
135MP0002733_abnormal_thermal_nociception0.95674340
136MP0003937_abnormal_limbs/digits/tail_de0.95644279
137MP0005409_darkened_coat_color0.94209643
138MP0000538_abnormal_urinary_bladder0.93361331
139MP0002067_abnormal_sensory_capabilities0.93272427
140MP0003567_abnormal_fetal_cardiomyocyte0.91698428
141MP0002405_respiratory_system_inflammati0.89596125
142MP0010678_abnormal_skin_adnexa0.89024279
143MP0002184_abnormal_innervation0.88511122
144MP0003718_maternal_effect0.88503744
145MP0000477_abnormal_intestine_morphology0.88203701
146MP0001764_abnormal_homeostasis0.87662756
147MP0000372_irregular_coat_pigmentation0.87390418
148MP0010386_abnormal_urinary_bladder0.87028763
149MP0004130_abnormal_muscle_cell0.86040034
150MP0005084_abnormal_gallbladder_morpholo0.85371518
151MP0005195_abnormal_posterior_eye0.85188697
152MP0002080_prenatal_lethality0.83600909
153MP0003119_abnormal_digestive_system0.82146438
154MP0001986_abnormal_taste_sensitivity0.82094317
155MP0008789_abnormal_olfactory_epithelium0.81751744
156MP0002210_abnormal_sex_determination0.81717162
157MP0001663_abnormal_digestive_system0.81438702
158MP0001324_abnormal_eye_pigmentation0.81236951
159MP0008961_abnormal_basal_metabolism0.80429948
160MP0002419_abnormal_innate_immunity0.78952946
161MP0001756_abnormal_urination0.77351642
162MP0001697_abnormal_embryo_size0.76504508
163MP0002234_abnormal_pharynx_morphology0.76356940
164MP0006035_abnormal_mitochondrial_morpho0.73964833
165MP0008995_early_reproductive_senescence0.73618765
166MP0001145_abnormal_male_reproductive0.73093953
167MP0010030_abnormal_orbit_morphology0.71365994
168MP0000049_abnormal_middle_ear0.71109008
169MP0000358_abnormal_cell_content/0.66254489
170MP0001845_abnormal_inflammatory_respons0.65404868
171MP0003806_abnormal_nucleotide_metabolis0.65132743
172MP0000653_abnormal_sex_gland0.64445172
173MP0002163_abnormal_gland_morphology0.64365969
174MP0008469_abnormal_protein_level0.63441807
175MP0005636_abnormal_mineral_homeostasis0.62835016
176MP0001119_abnormal_female_reproductive0.60254002
177MP0004381_abnormal_hair_follicle0.59283651
178MP0001929_abnormal_gametogenesis0.59120637

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.11428383
2Abnormal number of erythroid precursors (HP:0012131)7.91921504
3Reticulocytopenia (HP:0001896)5.85904719
4Aplastic anemia (HP:0001915)4.78068828
5Macrocytic anemia (HP:0001972)4.75765665
6Pallor (HP:0000980)4.59109017
7Decreased activity of mitochondrial respiratory chain (HP:0008972)4.21138638
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.21138638
9Hepatocellular necrosis (HP:0001404)4.11428108
10Oral leukoplakia (HP:0002745)4.02728111
11Pancreatic cysts (HP:0001737)3.85610886
12Birth length less than 3rd percentile (HP:0003561)3.74006296
13Hepatic necrosis (HP:0002605)3.67829432
14Congenital stationary night blindness (HP:0007642)3.56350837
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.54216683
16Mitochondrial inheritance (HP:0001427)3.52320793
17Type I transferrin isoform profile (HP:0003642)3.52270840
18Reduced antithrombin III activity (HP:0001976)3.46713635
19Thrombocytosis (HP:0001894)3.46608747
20Abnormality of midbrain morphology (HP:0002418)3.42349091
21Molar tooth sign on MRI (HP:0002419)3.42349091
22Microretrognathia (HP:0000308)3.38696060
23Pancreatic fibrosis (HP:0100732)3.33118307
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.28203287
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25577608
26Increased hepatocellular lipid droplets (HP:0006565)3.25405802
27Colon cancer (HP:0003003)3.23200532
28Increased CSF lactate (HP:0002490)3.12163972
29Abnormal protein glycosylation (HP:0012346)3.06714223
30Abnormal glycosylation (HP:0012345)3.06714223
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.06714223
32Abnormal protein N-linked glycosylation (HP:0012347)3.06714223
3311 pairs of ribs (HP:0000878)3.02064396
34True hermaphroditism (HP:0010459)3.01868987
35Increased serum lactate (HP:0002151)3.01543564
36Nephronophthisis (HP:0000090)2.97001475
37Exertional dyspnea (HP:0002875)2.96389417
38Acute necrotizing encephalopathy (HP:0006965)2.95400319
39Gaze-evoked nystagmus (HP:0000640)2.91128302
40Neoplasm of the adrenal cortex (HP:0100641)2.87851362
41Lipid accumulation in hepatocytes (HP:0006561)2.87686903
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.86958043
43Elevated erythrocyte sedimentation rate (HP:0003565)2.85207563
44Hyperventilation (HP:0002883)2.84785911
45Abnormal mitochondria in muscle tissue (HP:0008316)2.82783261
46Petechiae (HP:0000967)2.81584369
47Increased intramyocellular lipid droplets (HP:0012240)2.78559340
48Attenuation of retinal blood vessels (HP:0007843)2.75837962
49Genetic anticipation (HP:0003743)2.75412037
50IgM deficiency (HP:0002850)2.74805385
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71876288
52Rough bone trabeculation (HP:0100670)2.71462142
53Ketoacidosis (HP:0001993)2.65039330
54Pendular nystagmus (HP:0012043)2.64480363
55Abnormality of the renal cortex (HP:0011035)2.61358190
56Abnormality of the renal medulla (HP:0100957)2.59926050
57Chronic otitis media (HP:0000389)2.57918110
58Pancytopenia (HP:0001876)2.54493892
59Chromsome breakage (HP:0040012)2.53599019
60Ectopic kidney (HP:0000086)2.51269179
61Febrile seizures (HP:0002373)2.49774722
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49237409
63Thyroiditis (HP:0100646)2.48729012
64Large for gestational age (HP:0001520)2.48056744
65Breast hypoplasia (HP:0003187)2.47846872
66Hypoplasia of the pons (HP:0012110)2.47518981
67Protruding tongue (HP:0010808)2.46025648
68Abnormality of the pons (HP:0007361)2.44923078
69Lactic acidosis (HP:0003128)2.44883281
70Duplicated collecting system (HP:0000081)2.44836765
71Medial flaring of the eyebrow (HP:0010747)2.44468685
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.44172818
73Chronic hepatic failure (HP:0100626)2.43774870
74Severe visual impairment (HP:0001141)2.41709406
75Increased muscle lipid content (HP:0009058)2.39402383
76Abnormality of the renal collecting system (HP:0004742)2.38701424
77Abnormal drinking behavior (HP:0030082)2.38604229
78Polydipsia (HP:0001959)2.38604229
79Progressive muscle weakness (HP:0003323)2.38532296
80Poikiloderma (HP:0001029)2.38494957
81Progressive cerebellar ataxia (HP:0002073)2.37077003
82Premature graying of hair (HP:0002216)2.36324032
833-Methylglutaconic aciduria (HP:0003535)2.34679496
84Muscle fiber atrophy (HP:0100295)2.32602787
85Acute encephalopathy (HP:0006846)2.32426777
86Microvesicular hepatic steatosis (HP:0001414)2.29705188
87Type 2 muscle fiber atrophy (HP:0003554)2.29571292
88Abnormality of the preputium (HP:0100587)2.29282862
89Broad-based gait (HP:0002136)2.28896461
90Chorioretinal atrophy (HP:0000533)2.27100047
91Patellar aplasia (HP:0006443)2.26561224
92Renal Fanconi syndrome (HP:0001994)2.25922232
93Type II lissencephaly (HP:0007260)2.22536145
94Degeneration of anterior horn cells (HP:0002398)2.22391298
95Abnormality of the anterior horn cell (HP:0006802)2.22391298
96Furrowed tongue (HP:0000221)2.21013993
97Prolonged bleeding time (HP:0003010)2.19588995
98Respiratory difficulties (HP:0002880)2.19446341
99Aplasia/Hypoplasia of the patella (HP:0006498)2.18655493
100Cystic liver disease (HP:0006706)2.18611694
101Progressive macrocephaly (HP:0004481)2.18598315
102Tubular atrophy (HP:0000092)2.18515114
103Abnormality of reticulocytes (HP:0004312)2.18458153
104Myelodysplasia (HP:0002863)2.17017091
105Selective tooth agenesis (HP:0001592)2.16607281
106Exercise intolerance (HP:0003546)2.16025464
107Multiple enchondromatosis (HP:0005701)2.15280550
108Clubbing of toes (HP:0100760)2.14612291
109Sparse eyelashes (HP:0000653)2.13875948
110Hypothermia (HP:0002045)2.12463993
111Inability to walk (HP:0002540)2.12423396
112Respiratory failure (HP:0002878)2.10691413
113Tachypnea (HP:0002789)2.09356588
114Bony spicule pigmentary retinopathy (HP:0007737)2.09297074
115Abnormality of DNA repair (HP:0003254)2.09175461
116Hemiparesis (HP:0001269)2.08687649
117Decreased central vision (HP:0007663)2.08429080
118Progressive inability to walk (HP:0002505)2.06460490
119Pulmonary fibrosis (HP:0002206)2.06438783
120Lymphoma (HP:0002665)2.05854691
121Cerebral hypomyelination (HP:0006808)2.01045922
122Absent thumb (HP:0009777)1.99627528
123Lissencephaly (HP:0001339)1.99545205
124Small hand (HP:0200055)1.99543750
125Methylmalonic acidemia (HP:0002912)1.99490744
126Hyperinsulinemic hypoglycemia (HP:0000825)1.99337482
127Poor head control (HP:0002421)1.99084608
128Abnormality of the columella (HP:0009929)1.98851392
129Triphalangeal thumb (HP:0001199)1.97207646
130Ketosis (HP:0001946)1.95453317
131Abnormality of the axillary hair (HP:0100134)1.94092297
132Abnormality of secondary sexual hair (HP:0009888)1.94092297
133Abolished electroretinogram (ERG) (HP:0000550)1.93339517
134Bone marrow hypocellularity (HP:0005528)1.93191802
135Microcytic anemia (HP:0001935)1.93166772
136Congenital sensorineural hearing impairment (HP:0008527)1.92244107
137Severe muscular hypotonia (HP:0006829)1.91058808
138Absent speech (HP:0001344)1.90331279
139Fair hair (HP:0002286)1.89791562
140Renal cortical cysts (HP:0000803)1.89534640
141Meckel diverticulum (HP:0002245)1.89108081
142Abnormal trabecular bone morphology (HP:0100671)1.89101490
143Abnormal hemoglobin (HP:0011902)1.88368202
144Agnosia (HP:0010524)1.87634411
145Aplasia/Hypoplasia of the thymus (HP:0010515)1.87137095
146Impaired smooth pursuit (HP:0007772)1.87042352
147Hypoalbuminemia (HP:0003073)1.86530780
148Abnormal albumin level (HP:0012116)1.86530780
149Gait imbalance (HP:0002141)1.85373328
150Abnormality of the ileum (HP:0001549)1.84825725
151Decreased circulating renin level (HP:0003351)1.84452124
152Abnormality of T cell physiology (HP:0011840)1.84322134
153Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84081530
154Short 1st metacarpal (HP:0010034)1.84081530
155Sclerocornea (HP:0000647)1.83685585
156Depressed nasal ridge (HP:0000457)1.83269192
157Cleft eyelid (HP:0000625)1.80571324
158Short thumb (HP:0009778)1.80051358
159Epileptic encephalopathy (HP:0200134)1.79609526
160Intestinal atresia (HP:0011100)1.79608772
161Neoplasm of the pancreas (HP:0002894)1.79111171
162Epileptiform EEG discharges (HP:0011182)1.77769530
163Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77580937
164Trismus (HP:0000211)1.77126988
165Hamartoma of the eye (HP:0010568)1.76327508
166Sloping forehead (HP:0000340)1.76004000
167Methylmalonic aciduria (HP:0012120)1.75901356
168Concave nail (HP:0001598)1.75638607
169Clumsiness (HP:0002312)1.75479368
170Polyuria (HP:0000103)1.75356290
171Short middle phalanx of the 5th finger (HP:0004220)1.75109150
172Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74800758
173Emotional lability (HP:0000712)1.73661918
174Migraine (HP:0002076)1.73490250
175Congenital primary aphakia (HP:0007707)1.73103032
176EEG with generalized epileptiform discharges (HP:0011198)1.72331549
177Cellular immunodeficiency (HP:0005374)1.72208810
178Congenital hepatic fibrosis (HP:0002612)1.71794604
179Hypoplasia of the radius (HP:0002984)1.71581359
180Absent radius (HP:0003974)1.71395910
181Abnormal rod and cone electroretinograms (HP:0008323)1.71232033
182Self-mutilation (HP:0000742)1.71177973
183Hypsarrhythmia (HP:0002521)1.71128060
184Poor coordination (HP:0002370)1.70681249
185Abnormality of chromosome stability (HP:0003220)1.69708625
186Severe combined immunodeficiency (HP:0004430)1.69194828
187Male pseudohermaphroditism (HP:0000037)1.69152068
188Slender long bone (HP:0003100)1.68944234
189Keratoconus (HP:0000563)1.67559098
190Increased corneal curvature (HP:0100692)1.67559098
191Hypoplasia of the thymus (HP:0000778)1.67270763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.52217007
2NME24.62681171
3STK164.13354921
4ACVR1B3.28991832
5WEE13.20268728
6BUB13.06210601
7TLK12.98989339
8CDC72.92581937
9VRK12.89433708
10ZAK2.69690782
11GRK12.42594272
12SRPK12.40580877
13CDK192.35735455
14NUAK12.33243536
15EIF2AK32.32980664
16KDR2.27860880
17PIM22.25534021
18WNK42.10374749
19CASK2.01513189
20TEC1.99348193
21WNK31.98260038
22EIF2AK11.98013196
23CDK81.92847345
24SCYL21.82644338
25MAP3K41.80692680
26STK391.78751650
27FGFR21.77526659
28DYRK31.77354527
29TNIK1.74431483
30TAF11.68006050
31TRIM281.66114428
32NEK21.63125460
33MKNK11.63074937
34OXSR11.56393140
35CDK71.53846220
36AKT31.53489775
37TESK21.51132782
38TGFBR11.48987727
39MAPK131.45147480
40INSRR1.41304740
41MAP4K21.39606041
42MAP4K11.39055737
43PINK11.36945106
44KIT1.35724032
45MKNK21.35198144
46PAK31.28043134
47AURKB1.27960866
48BTK1.27959263
49PLK21.21294837
50BRSK21.19385328
51LRRK21.18045648
52IRAK41.18037238
53MUSK1.17400296
54TAOK31.16957400
55DAPK21.13774922
56RPS6KB21.13705730
57FLT31.12712723
58CCNB11.11537967
59MAP3K111.10820097
60PLK11.10100565
61CDK41.09071882
62ATR1.07783288
63PHKG11.05126219
64PHKG21.05126219
65BMPR1B1.03648196
66MAP3K121.00434474
67NME11.00103415
68ILK0.97901823
69PRKCG0.95881134
70AURKA0.95736561
71MAPKAPK30.95113437
72RPS6KA40.90844293
73ABL20.90368274
74MAP2K70.89742806
75MAP2K30.89419452
76RAF10.89338548
77BCKDK0.87658316
78PLK30.86680882
79NLK0.86497522
80ADRBK10.84914162
81CSNK1G20.83665278
82CLK10.83185920
83BLK0.82128894
84DAPK10.81527242
85MARK10.81423731
86ZAP700.79839114
87CSNK1G10.79560277
88FES0.76510372
89CHEK20.75079271
90MAPKAPK50.75023532
91CSNK1A1L0.74606005
92STK110.72794889
93PRKCE0.72550593
94MELK0.72071128
95STK38L0.72006316
96NTRK30.71953844
97CSNK2A20.71322085
98CSNK1G30.70313456
99PRKAA10.70253155
100CSNK2A10.69821566
101TTK0.68681455
102EIF2AK20.67689874
103CAMK1G0.66093847
104BRSK10.65123161
105LYN0.63563380
106CAMK1D0.62479649
107SYK0.61417448
108SGK20.61197586
109IRAK30.60560435
110EPHA40.60476736
111STK30.60311386
112ERBB30.59497135
113MAP3K60.58660571
114VRK20.58278361
115PRKAA20.56820684
116PIM10.56565680
117PRKCI0.56135361
118PAK40.56105643
119PIK3CA0.54784793
120TBK10.54042770
121PASK0.53740502
122DAPK30.52800514
123TRPM70.51317518
124CSNK1D0.51174968
125JAK30.49342040
126TYK20.49305735
127MATK0.49209818
128MAP3K80.49034594
129MST40.48920338
130CSF1R0.47688056
131PRKCQ0.47353404
132MAP2K60.47258509
133ATM0.46895444
134MAP3K100.44083671
135CHUK0.42967239
136TIE10.42447147
137DYRK20.41946466
138FER0.41700519
139YES10.41154085
140SIK20.40884212
141NTRK20.40855316
142IKBKB0.40341978
143PNCK0.39896560
144SGK2230.38469754
145SGK4940.38469754
146PAK10.38399960
147CHEK10.38294241
148HIPK20.37760593
149TNK20.37520303
150ADRBK20.37305509
151STK40.36993200
152MAPK110.36953698
153LCK0.36637053
154BRAF0.36433368
155TESK10.36157092
156RPS6KA50.35930803
157CSNK1A10.35286629
158MAP2K10.35047333
159PRKCH0.34631566
160MAPK150.34562082
161PLK40.34404228
162CAMKK10.33722582
163MAP2K20.33337535
164CAMKK20.31389456
165CDK20.30909584
166IKBKE0.30475707
167CAMK10.30237937

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.20813585
2DNA replication_Homo sapiens_hsa030305.40878126
3Mismatch repair_Homo sapiens_hsa034304.29517073
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.49471140
5RNA polymerase_Homo sapiens_hsa030203.40119595
6Homologous recombination_Homo sapiens_hsa034403.18909587
7Base excision repair_Homo sapiens_hsa034103.18028554
8Proteasome_Homo sapiens_hsa030503.17045093
9Pyrimidine metabolism_Homo sapiens_hsa002402.89260524
10Spliceosome_Homo sapiens_hsa030402.86738188
11Nucleotide excision repair_Homo sapiens_hsa034202.80254499
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65747971
13Phototransduction_Homo sapiens_hsa047442.47799847
14Nicotine addiction_Homo sapiens_hsa050332.35300242
15Butanoate metabolism_Homo sapiens_hsa006502.12162461
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96256943
17Parkinsons disease_Homo sapiens_hsa050121.95221790
18Oxidative phosphorylation_Homo sapiens_hsa001901.90660510
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90495314
20Fanconi anemia pathway_Homo sapiens_hsa034601.87676651
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78676530
22Protein export_Homo sapiens_hsa030601.78350246
23RNA transport_Homo sapiens_hsa030131.77049239
24Sulfur relay system_Homo sapiens_hsa041221.76458531
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76011136
26Cell cycle_Homo sapiens_hsa041101.71101039
27Nitrogen metabolism_Homo sapiens_hsa009101.69948769
28Insulin secretion_Homo sapiens_hsa049111.69317074
29Taste transduction_Homo sapiens_hsa047421.58632361
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55939028
31One carbon pool by folate_Homo sapiens_hsa006701.55899440
32Huntingtons disease_Homo sapiens_hsa050161.50276336
33Purine metabolism_Homo sapiens_hsa002301.49715435
34* RNA degradation_Homo sapiens_hsa030181.43024285
35Tryptophan metabolism_Homo sapiens_hsa003801.41557014
36Basal transcription factors_Homo sapiens_hsa030221.40270464
37Non-homologous end-joining_Homo sapiens_hsa034501.36976199
38Dorso-ventral axis formation_Homo sapiens_hsa043201.36864026
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36254756
40Ether lipid metabolism_Homo sapiens_hsa005651.35551145
41Regulation of autophagy_Homo sapiens_hsa041401.32330596
42Folate biosynthesis_Homo sapiens_hsa007901.27099403
43Morphine addiction_Homo sapiens_hsa050321.24567829
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22261013
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15848784
46Alzheimers disease_Homo sapiens_hsa050101.15114070
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14759075
48Collecting duct acid secretion_Homo sapiens_hsa049661.11794054
49N-Glycan biosynthesis_Homo sapiens_hsa005101.11521507
50Glutamatergic synapse_Homo sapiens_hsa047241.10226809
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09658765
52Vitamin B6 metabolism_Homo sapiens_hsa007501.07341781
53Ovarian steroidogenesis_Homo sapiens_hsa049131.06265025
54Circadian entrainment_Homo sapiens_hsa047131.05094146
55ABC transporters_Homo sapiens_hsa020101.04349097
56Pentose phosphate pathway_Homo sapiens_hsa000301.02175275
57GABAergic synapse_Homo sapiens_hsa047271.00033594
58Primary immunodeficiency_Homo sapiens_hsa053400.99012881
59p53 signaling pathway_Homo sapiens_hsa041150.98615788
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97120120
61Systemic lupus erythematosus_Homo sapiens_hsa053220.93777574
62Serotonergic synapse_Homo sapiens_hsa047260.91378914
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90972183
64Calcium signaling pathway_Homo sapiens_hsa040200.89502153
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87551002
66Type II diabetes mellitus_Homo sapiens_hsa049300.86295779
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.86116662
68Olfactory transduction_Homo sapiens_hsa047400.85340501
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.84409189
70Herpes simplex infection_Homo sapiens_hsa051680.80982051
71Lysine degradation_Homo sapiens_hsa003100.78815907
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.77183290
73Dopaminergic synapse_Homo sapiens_hsa047280.75229274
74Amphetamine addiction_Homo sapiens_hsa050310.75029369
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74206204
76Peroxisome_Homo sapiens_hsa041460.73270036
77Sulfur metabolism_Homo sapiens_hsa009200.71614877
78Epstein-Barr virus infection_Homo sapiens_hsa051690.70286372
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.69036933
80Salivary secretion_Homo sapiens_hsa049700.68823732
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68281417
82Circadian rhythm_Homo sapiens_hsa047100.68087738
83Antigen processing and presentation_Homo sapiens_hsa046120.67942439
84Glutathione metabolism_Homo sapiens_hsa004800.66115249
85mRNA surveillance pathway_Homo sapiens_hsa030150.65662394
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65037574
87Propanoate metabolism_Homo sapiens_hsa006400.62668632
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62167121
89Basal cell carcinoma_Homo sapiens_hsa052170.62020933
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61257751
91Thyroid cancer_Homo sapiens_hsa052160.58448572
92Glycerolipid metabolism_Homo sapiens_hsa005610.57576650
93Hedgehog signaling pathway_Homo sapiens_hsa043400.57365497
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56175049
95Hematopoietic cell lineage_Homo sapiens_hsa046400.55633853
96Other glycan degradation_Homo sapiens_hsa005110.54994043
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52960262
98Hippo signaling pathway_Homo sapiens_hsa043900.50366084
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50074617
100Renin secretion_Homo sapiens_hsa049240.49404690
101Metabolic pathways_Homo sapiens_hsa011000.48226773
102Mineral absorption_Homo sapiens_hsa049780.48078096
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48077762
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.46723767
105Cocaine addiction_Homo sapiens_hsa050300.46143172
106Long-term depression_Homo sapiens_hsa047300.45925038
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45506164
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44732562
109cAMP signaling pathway_Homo sapiens_hsa040240.44381274
110mTOR signaling pathway_Homo sapiens_hsa041500.43939130
111Oxytocin signaling pathway_Homo sapiens_hsa049210.43368247
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43045436
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.43041071
114TGF-beta signaling pathway_Homo sapiens_hsa043500.42926221
115Chemical carcinogenesis_Homo sapiens_hsa052040.41981980
116Cholinergic synapse_Homo sapiens_hsa047250.41592299
117beta-Alanine metabolism_Homo sapiens_hsa004100.40991561
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40186555
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38788364
120Shigellosis_Homo sapiens_hsa051310.38717064
121Cardiac muscle contraction_Homo sapiens_hsa042600.38622802
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37924537
123Melanoma_Homo sapiens_hsa052180.37918061
124HTLV-I infection_Homo sapiens_hsa051660.37583309
125Gastric acid secretion_Homo sapiens_hsa049710.36963970
126Arachidonic acid metabolism_Homo sapiens_hsa005900.36533893
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36328375
128Measles_Homo sapiens_hsa051620.36277526
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.36214118
130Alcoholism_Homo sapiens_hsa050340.33386843
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32681850
132Leishmaniasis_Homo sapiens_hsa051400.28145058
133Viral carcinogenesis_Homo sapiens_hsa052030.28093951
134Apoptosis_Homo sapiens_hsa042100.27993069
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25565686
136Biosynthesis of amino acids_Homo sapiens_hsa012300.25158944
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.24713952
138Bladder cancer_Homo sapiens_hsa052190.22893382
139Legionellosis_Homo sapiens_hsa051340.22657693
140Acute myeloid leukemia_Homo sapiens_hsa052210.22646762
141Carbon metabolism_Homo sapiens_hsa012000.21882522
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.21550380
143Renin-angiotensin system_Homo sapiens_hsa046140.20253991
144Galactose metabolism_Homo sapiens_hsa000520.20002398
145Hepatitis B_Homo sapiens_hsa051610.19269155
146Caffeine metabolism_Homo sapiens_hsa002320.18236592
147Asthma_Homo sapiens_hsa053100.18016685
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17313990
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17312613
150Selenocompound metabolism_Homo sapiens_hsa004500.16202465
151Oocyte meiosis_Homo sapiens_hsa041140.15184656
152Small cell lung cancer_Homo sapiens_hsa052220.12594336
153Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12209182
154B cell receptor signaling pathway_Homo sapiens_hsa046620.12145390
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.12107967
156Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.11513968
157Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10691897
158Allograft rejection_Homo sapiens_hsa053300.09166187
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08917183
160Pertussis_Homo sapiens_hsa051330.08372632
161Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07380980
162Linoleic acid metabolism_Homo sapiens_hsa005910.05641419
163Salmonella infection_Homo sapiens_hsa051320.05359409
164Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.05045970
165Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.04587910

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