

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.07798201 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 5.47657669 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 5.08977577 |
| 4 | proteasome assembly (GO:0043248) | 4.97868717 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 4.63967885 |
| 6 | ribosomal small subunit biogenesis (GO:0042274) | 4.63905204 |
| 7 | purine nucleobase biosynthetic process (GO:0009113) | 4.54535298 |
| 8 | nucleobase biosynthetic process (GO:0046112) | 4.54190456 |
| 9 | viral transcription (GO:0019083) | 4.54045356 |
| 10 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.47360621 |
| 11 | rRNA modification (GO:0000154) | 4.45660503 |
| 12 | translational termination (GO:0006415) | 4.43813988 |
| 13 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.37969402 |
| 14 | ribosomal large subunit biogenesis (GO:0042273) | 4.31563660 |
| 15 | DNA strand elongation (GO:0022616) | 4.28598940 |
| 16 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.28083559 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.25730183 |
| 18 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.23750504 |
| 19 | pseudouridine synthesis (GO:0001522) | 4.21466869 |
| 20 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.20073512 |
| 21 | termination of RNA polymerase III transcription (GO:0006386) | 4.20073512 |
| 22 | formation of translation preinitiation complex (GO:0001731) | 4.19255871 |
| 23 | CENP-A containing nucleosome assembly (GO:0034080) | 4.15003172 |
| 24 | ribosome biogenesis (GO:0042254) | 4.11867986 |
| 25 | DNA replication initiation (GO:0006270) | 4.07864486 |
| 26 | translational elongation (GO:0006414) | 4.06035104 |
| 27 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.05782186 |
| 28 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.00643439 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.00560516 |
| 30 | respiratory electron transport chain (GO:0022904) | 3.99335887 |
| 31 | cotranslational protein targeting to membrane (GO:0006613) | 3.99300891 |
| 32 | chromatin remodeling at centromere (GO:0031055) | 3.96198020 |
| 33 | DNA replication checkpoint (GO:0000076) | 3.95978799 |
| 34 | protein targeting to ER (GO:0045047) | 3.94897667 |
| 35 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.94774849 |
| 36 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.93915917 |
| 37 | electron transport chain (GO:0022900) | 3.91597180 |
| 38 | telomere maintenance via recombination (GO:0000722) | 3.91558261 |
| 39 | * rRNA processing (GO:0006364) | 3.91082190 |
| 40 | translational initiation (GO:0006413) | 3.90246259 |
| 41 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.87703467 |
| 42 | negative regulation of ligase activity (GO:0051352) | 3.87703467 |
| 43 | protein complex biogenesis (GO:0070271) | 3.87599774 |
| 44 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.82625033 |
| 45 | ribosome assembly (GO:0042255) | 3.79878970 |
| 46 | protein localization to endoplasmic reticulum (GO:0070972) | 3.79664996 |
| 47 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.78123936 |
| 48 | spliceosomal snRNP assembly (GO:0000387) | 3.77105058 |
| 49 | * rRNA metabolic process (GO:0016072) | 3.76549556 |
| 50 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.76003894 |
| 51 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.76003894 |
| 52 | NADH dehydrogenase complex assembly (GO:0010257) | 3.76003894 |
| 53 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.74255876 |
| 54 | 7-methylguanosine mRNA capping (GO:0006370) | 3.73516723 |
| 55 | translation (GO:0006412) | 3.68918532 |
| 56 | rRNA methylation (GO:0031167) | 3.67840855 |
| 57 | 7-methylguanosine RNA capping (GO:0009452) | 3.67670747 |
| 58 | RNA capping (GO:0036260) | 3.67670747 |
| 59 | cellular component biogenesis (GO:0044085) | 3.65257319 |
| 60 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.63745145 |
| 61 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.63638471 |
| 62 | regulation of mitochondrial translation (GO:0070129) | 3.60095459 |
| 63 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.60054151 |
| 64 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.60054151 |
| 65 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.60054151 |
| 66 | respiratory chain complex IV assembly (GO:0008535) | 3.59931528 |
| 67 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.59113957 |
| 68 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.59113957 |
| 69 | mitotic recombination (GO:0006312) | 3.56770509 |
| 70 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.55117244 |
| 71 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.54193994 |
| 72 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.53767231 |
| 73 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.52425374 |
| 74 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.52425374 |
| 75 | cellular protein complex disassembly (GO:0043624) | 3.51257754 |
| 76 | viral life cycle (GO:0019058) | 3.50945690 |
| 77 | DNA replication-independent nucleosome organization (GO:0034724) | 3.49867217 |
| 78 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.49867217 |
| 79 | viral mRNA export from host cell nucleus (GO:0046784) | 3.49552473 |
| 80 | protein neddylation (GO:0045116) | 3.48428218 |
| 81 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.47121224 |
| 82 | telomere maintenance via telomere lengthening (GO:0010833) | 3.45592186 |
| 83 | DNA double-strand break processing (GO:0000729) | 3.44683464 |
| 84 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.42224070 |
| 85 | spliceosomal complex assembly (GO:0000245) | 3.40590049 |
| 86 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.39725750 |
| 87 | termination of RNA polymerase I transcription (GO:0006363) | 3.38111051 |
| 88 | protein targeting to mitochondrion (GO:0006626) | 3.38025428 |
| 89 | maturation of 5.8S rRNA (GO:0000460) | 3.37122560 |
| 90 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.35733270 |
| 91 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.33342840 |
| 92 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.33342840 |
| 93 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.32667778 |
| 94 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.32667778 |
| 95 | * exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.30853836 |
| 96 | cytochrome complex assembly (GO:0017004) | 3.28738958 |
| 97 | peptidyl-histidine modification (GO:0018202) | 3.28604435 |
| 98 | positive regulation of ligase activity (GO:0051351) | 3.28344421 |
| 99 | kinetochore assembly (GO:0051382) | 3.25981021 |
| 100 | * nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.24915902 |
| 101 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.24831074 |
| 102 | cell cycle G1/S phase transition (GO:0044843) | 3.24831074 |
| 103 | histone exchange (GO:0043486) | 3.24776015 |
| 104 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.24283446 |
| 105 | mitotic metaphase plate congression (GO:0007080) | 3.23827169 |
| 106 | DNA unwinding involved in DNA replication (GO:0006268) | 3.23081001 |
| 107 | transcription from RNA polymerase I promoter (GO:0006360) | 3.22777273 |
| 108 | amino acid salvage (GO:0043102) | 3.21476624 |
| 109 | L-methionine salvage (GO:0071267) | 3.21476624 |
| 110 | L-methionine biosynthetic process (GO:0071265) | 3.21476624 |
| 111 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.21136872 |
| 112 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.20990729 |
| 113 | ATP synthesis coupled proton transport (GO:0015986) | 3.20990729 |
| 114 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.17985987 |
| 115 | kinetochore organization (GO:0051383) | 3.17970967 |
| 116 | establishment of protein localization to mitochondrion (GO:0072655) | 3.17953417 |
| 117 | IMP biosynthetic process (GO:0006188) | 3.17139754 |
| 118 | DNA damage response, detection of DNA damage (GO:0042769) | 3.16273465 |
| 119 | protein localization to mitochondrion (GO:0070585) | 3.14873607 |
| 120 | oxidative phosphorylation (GO:0006119) | 3.11932620 |
| 121 | establishment of integrated proviral latency (GO:0075713) | 3.11484887 |
| 122 | cullin deneddylation (GO:0010388) | 3.11217337 |
| 123 | protein deneddylation (GO:0000338) | 3.11149583 |
| 124 | replication fork processing (GO:0031297) | 3.10817020 |
| 125 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.10314025 |
| 126 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.08374180 |
| 127 | inner mitochondrial membrane organization (GO:0007007) | 3.07774273 |
| 128 | regulation of ligase activity (GO:0051340) | 2.96903362 |
| 129 | histone mRNA metabolic process (GO:0008334) | 2.94080932 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.13745093 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.51683707 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.32679100 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.94148274 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.89374041 |
| 6 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.85221442 |
| 7 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.82997869 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.55900949 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.38361164 |
| 10 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.21250289 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.20106468 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.19812631 |
| 13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.08014349 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.01725865 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.00511281 |
| 16 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.97140269 |
| 17 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.95735036 |
| 18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.71148230 |
| 19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.70126110 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.67722131 |
| 21 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.67075624 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.60513729 |
| 23 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.46136356 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.45229698 |
| 25 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.33245489 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.31681210 |
| 27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.30953335 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.27124747 |
| 29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.20597619 |
| 30 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.16006935 |
| 31 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.10438019 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.09459979 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.03315737 |
| 34 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.97996433 |
| 35 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.94368607 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.92047540 |
| 37 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.91643839 |
| 38 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.89857294 |
| 39 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.83474961 |
| 40 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.80044416 |
| 41 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78907682 |
| 42 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.78391934 |
| 43 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.77874437 |
| 44 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.77609936 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.75985974 |
| 46 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.72081503 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.71437696 |
| 48 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.69592796 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.69485142 |
| 50 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.69246521 |
| 51 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.61961353 |
| 52 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.60313016 |
| 53 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.57441867 |
| 54 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.48762352 |
| 55 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.47653326 |
| 56 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.47460575 |
| 57 | VDR_22108803_ChIP-Seq_LS180_Human | 1.47048312 |
| 58 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.41042166 |
| 59 | EWS_26573619_Chip-Seq_HEK293_Human | 1.39944720 |
| 60 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36068769 |
| 61 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.31812982 |
| 62 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.30152518 |
| 63 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.26341174 |
| 64 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.23401638 |
| 65 | FUS_26573619_Chip-Seq_HEK293_Human | 1.20089775 |
| 66 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.19650602 |
| 67 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.19047321 |
| 68 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.18216300 |
| 69 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.17727172 |
| 70 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.16355344 |
| 71 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.15771695 |
| 72 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.15611558 |
| 73 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.13749127 |
| 74 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.11949621 |
| 75 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.10547075 |
| 76 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.10519587 |
| 77 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.09585387 |
| 78 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.04974523 |
| 79 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.04595355 |
| 80 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.02820844 |
| 81 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.02168771 |
| 82 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99522574 |
| 83 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.98399832 |
| 84 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.94784960 |
| 85 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.93587852 |
| 86 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.93437010 |
| 87 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.92673298 |
| 88 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.92628499 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.92336229 |
| 90 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.90604390 |
| 91 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.90571137 |
| 92 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.90096334 |
| 93 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.88951916 |
| 94 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.88748747 |
| 95 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.87173665 |
| 96 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.86540000 |
| 97 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.85200933 |
| 98 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.85153447 |
| 99 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.84489261 |
| 100 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83715469 |
| 101 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.83468995 |
| 102 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83017781 |
| 103 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.81244204 |
| 104 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.80385968 |
| 105 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.79717620 |
| 106 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.78701306 |
| 107 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.75919101 |
| 108 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.74816193 |
| 109 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.74162665 |
| 110 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.74004355 |
| 111 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.73756419 |
| 112 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.72431615 |
| 113 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.71254653 |
| 114 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.70748591 |
| 115 | P300_19829295_ChIP-Seq_ESCs_Human | 0.69499999 |
| 116 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.69333676 |
| 117 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.69246250 |
| 118 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.67967818 |
| 119 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.62715322 |
| 120 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.62715322 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.08496647 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.77117064 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.45120077 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.16106060 |
| 5 | MP0008058_abnormal_DNA_repair | 3.99991127 |
| 6 | MP0008057_abnormal_DNA_replication | 3.73674630 |
| 7 | MP0003077_abnormal_cell_cycle | 3.71613709 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.87973866 |
| 9 | MP0009379_abnormal_foot_pigmentation | 2.79799121 |
| 10 | MP0003718_maternal_effect | 2.77763182 |
| 11 | MP0003806_abnormal_nucleotide_metabolis | 2.63610795 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.60842857 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.58537980 |
| 14 | MP0002102_abnormal_ear_morphology | 2.48676244 |
| 15 | MP0003786_premature_aging | 2.46495366 |
| 16 | MP0008877_abnormal_DNA_methylation | 2.18616011 |
| 17 | MP0003123_paternal_imprinting | 2.06688895 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 2.01467856 |
| 19 | MP0006292_abnormal_olfactory_placode | 1.94763524 |
| 20 | MP0006072_abnormal_retinal_apoptosis | 1.91208388 |
| 21 | MP0001730_embryonic_growth_arrest | 1.78897025 |
| 22 | MP0005075_abnormal_melanosome_morpholog | 1.78780812 |
| 23 | MP0003186_abnormal_redox_activity | 1.75437281 |
| 24 | MP0006035_abnormal_mitochondrial_morpho | 1.65083550 |
| 25 | MP0002132_abnormal_respiratory_system | 1.64676394 |
| 26 | MP0000490_abnormal_crypts_of | 1.62588462 |
| 27 | MP0004147_increased_porphyrin_level | 1.62330225 |
| 28 | MP0009333_abnormal_splenocyte_physiolog | 1.57401567 |
| 29 | MP0003315_abnormal_perineum_morphology | 1.54844943 |
| 30 | MP0000350_abnormal_cell_proliferation | 1.54010792 |
| 31 | MP0008789_abnormal_olfactory_epithelium | 1.52325228 |
| 32 | MP0003763_abnormal_thymus_physiology | 1.51919106 |
| 33 | MP0009697_abnormal_copulation | 1.51659772 |
| 34 | MP0001986_abnormal_taste_sensitivity | 1.43022423 |
| 35 | MP0001764_abnormal_homeostasis | 1.37898756 |
| 36 | MP0008260_abnormal_autophagy | 1.37826965 |
| 37 | MP0000313_abnormal_cell_death | 1.36600671 |
| 38 | MP0002234_abnormal_pharynx_morphology | 1.28767573 |
| 39 | MP0002736_abnormal_nociception_after | 1.28749950 |
| 40 | MP0002837_dystrophic_cardiac_calcinosis | 1.28544074 |
| 41 | MP0002019_abnormal_tumor_incidence | 1.28317929 |
| 42 | MP0005551_abnormal_eye_electrophysiolog | 1.26113189 |
| 43 | MP0001529_abnormal_vocalization | 1.23312140 |
| 44 | MP0003567_abnormal_fetal_cardiomyocyte | 1.22709598 |
| 45 | MP0002095_abnormal_skin_pigmentation | 1.22152260 |
| 46 | MP0005645_abnormal_hypothalamus_physiol | 1.22079456 |
| 47 | MP0005253_abnormal_eye_physiology | 1.21999038 |
| 48 | MP0003195_calcinosis | 1.20811965 |
| 49 | MP0002080_prenatal_lethality | 1.19522379 |
| 50 | MP0003011_delayed_dark_adaptation | 1.17141148 |
| 51 | MP0003941_abnormal_skin_development | 1.16808709 |
| 52 | MP0001697_abnormal_embryo_size | 1.16109026 |
| 53 | MP0002210_abnormal_sex_determination | 1.15140843 |
| 54 | MP0001853_heart_inflammation | 1.14397151 |
| 55 | MP0003937_abnormal_limbs/digits/tail_de | 1.13120078 |
| 56 | MP0002751_abnormal_autonomic_nervous | 1.09605800 |
| 57 | MP0003890_abnormal_embryonic-extraembry | 1.09545082 |
| 58 | MP0003880_abnormal_central_pattern | 1.08127465 |
| 59 | MP0000358_abnormal_cell_content/ | 1.07906957 |
| 60 | MP0004808_abnormal_hematopoietic_stem | 1.07798775 |
| 61 | MP0003646_muscle_fatigue | 1.07705525 |
| 62 | MP0001188_hyperpigmentation | 1.06953878 |
| 63 | MP0002398_abnormal_bone_marrow | 1.06550050 |
| 64 | MP0001984_abnormal_olfaction | 1.05189306 |
| 65 | MP0005174_abnormal_tail_pigmentation | 1.05131729 |
| 66 | MP0002938_white_spotting | 1.04738885 |
| 67 | MP0005389_reproductive_system_phenotype | 1.03964550 |
| 68 | MP0002722_abnormal_immune_system | 1.03893331 |
| 69 | MP0001672_abnormal_embryogenesis/_devel | 1.03884444 |
| 70 | MP0005380_embryogenesis_phenotype | 1.03884444 |
| 71 | MP0005671_abnormal_response_to | 1.03882999 |
| 72 | MP0001145_abnormal_male_reproductive | 1.03737550 |
| 73 | MP0005397_hematopoietic_system_phenotyp | 1.03498835 |
| 74 | MP0001545_abnormal_hematopoietic_system | 1.03498835 |
| 75 | MP0010030_abnormal_orbit_morphology | 1.00295699 |
| 76 | MP0000689_abnormal_spleen_morphology | 1.00156090 |
| 77 | MP0002160_abnormal_reproductive_system | 0.99870740 |
| 78 | MP0005499_abnormal_olfactory_system | 0.99299606 |
| 79 | MP0005394_taste/olfaction_phenotype | 0.99299606 |
| 80 | MP0001905_abnormal_dopamine_level | 0.98780972 |
| 81 | MP0001929_abnormal_gametogenesis | 0.96466382 |
| 82 | MP0000653_abnormal_sex_gland | 0.94293356 |
| 83 | MP0000703_abnormal_thymus_morphology | 0.93608941 |
| 84 | MP0000015_abnormal_ear_pigmentation | 0.93478323 |
| 85 | MP0002090_abnormal_vision | 0.90472188 |
| 86 | MP0001968_abnormal_touch/_nociception | 0.90326424 |
| 87 | MP0002429_abnormal_blood_cell | 0.90264180 |
| 88 | MP0000631_abnormal_neuroendocrine_gland | 0.88905484 |
| 89 | MP0000566_synostosis | 0.88793525 |
| 90 | MP0000647_abnormal_sebaceous_gland | 0.87843036 |
| 91 | MP0003984_embryonic_growth_retardation | 0.87180113 |
| 92 | MP0001919_abnormal_reproductive_system | 0.86827931 |
| 93 | MP0005332_abnormal_amino_acid | 0.86141599 |
| 94 | MP0004142_abnormal_muscle_tone | 0.85544652 |
| 95 | MP0008872_abnormal_physiological_respon | 0.85030205 |
| 96 | MP0001485_abnormal_pinna_reflex | 0.84987728 |
| 97 | MP0002088_abnormal_embryonic_growth/wei | 0.82760715 |
| 98 | MP0003119_abnormal_digestive_system | 0.82223427 |
| 99 | MP0005266_abnormal_metabolism | 0.80603138 |
| 100 | MP0000049_abnormal_middle_ear | 0.80456633 |
| 101 | MP0002233_abnormal_nose_morphology | 0.80320368 |
| 102 | MP0003698_abnormal_male_reproductive | 0.79681861 |
| 103 | MP0001119_abnormal_female_reproductive | 0.78584474 |
| 104 | MP0003136_yellow_coat_color | 0.78247563 |
| 105 | MP0002254_reproductive_system_inflammat | 0.77929089 |
| 106 | MP0003787_abnormal_imprinting | 0.77140680 |
| 107 | MP0002085_abnormal_embryonic_tissue | 0.75496030 |
| 108 | MP0000716_abnormal_immune_system | 0.75000353 |
| 109 | MP0003656_abnormal_erythrocyte_physiolo | 0.74657545 |
| 110 | MP0001324_abnormal_eye_pigmentation | 0.74076165 |
| 111 | MP0005636_abnormal_mineral_homeostasis | 0.73355420 |
| 112 | MP0009046_muscle_twitch | 0.73221384 |
| 113 | MP0004782_abnormal_surfactant_physiolog | 0.73120068 |
| 114 | MP0004145_abnormal_muscle_electrophysio | 0.72842482 |
| 115 | MP0001286_abnormal_eye_development | 0.72526900 |
| 116 | MP0005408_hypopigmentation | 0.71577728 |
| 117 | MP0004215_abnormal_myocardial_fiber | 0.71192992 |
| 118 | MP0006276_abnormal_autonomic_nervous | 0.69194148 |
| 119 | MP0005360_urolithiasis | 0.68684698 |
| 120 | MP0005084_abnormal_gallbladder_morpholo | 0.67931826 |
| 121 | MP0002638_abnormal_pupillary_reflex | 0.66756514 |
| 122 | MP0000465_gastrointestinal_hemorrhage | 0.65423238 |
| 123 | MP0003121_genomic_imprinting | 0.65086535 |
| 124 | MP0008995_early_reproductive_senescence | 0.64180571 |
| 125 | MP0005384_cellular_phenotype | 0.63647089 |
| 126 | MP0002086_abnormal_extraembryonic_tissu | 0.61548090 |
| 127 | MP0003866_abnormal_defecation | 0.60498631 |
| 128 | MP0002876_abnormal_thyroid_physiology | 0.60252206 |
| 129 | MP0002277_abnormal_respiratory_mucosa | 0.60236690 |
| 130 | MP0004381_abnormal_hair_follicle | 0.59480379 |
| 131 | MP0002163_abnormal_gland_morphology | 0.59424269 |
| 132 | MP0003221_abnormal_cardiomyocyte_apopto | 0.58173037 |
| 133 | MP0001542_abnormal_bone_strength | 0.57289065 |
| 134 | MP0002084_abnormal_developmental_patter | 0.57092123 |
| 135 | MP0005395_other_phenotype | 0.56349621 |
| 136 | MP0000372_irregular_coat_pigmentation | 0.56294099 |
| 137 | MP0001186_pigmentation_phenotype | 0.55499022 |
| 138 | MP0001835_abnormal_antigen_presentation | 0.54038721 |
| 139 | MP0002420_abnormal_adaptive_immunity | 0.52959554 |
| 140 | MP0001293_anophthalmia | 0.51937775 |
| 141 | MP0004133_heterotaxia | 0.51578148 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.64445415 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.56883943 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 5.09679144 |
| 4 | Hepatocellular necrosis (HP:0001404) | 4.02588354 |
| 5 | Reticulocytopenia (HP:0001896) | 4.02047120 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.89664949 |
| 7 | Acute necrotizing encephalopathy (HP:0006965) | 3.84303659 |
| 8 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.76063788 |
| 9 | Hepatic necrosis (HP:0002605) | 3.70151070 |
| 10 | Macrocytic anemia (HP:0001972) | 3.65426001 |
| 11 | Breast hypoplasia (HP:0003187) | 3.63524164 |
| 12 | Increased CSF lactate (HP:0002490) | 3.63325659 |
| 13 | Aplastic anemia (HP:0001915) | 3.61160266 |
| 14 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.57486295 |
| 15 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.57486295 |
| 16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.57032945 |
| 17 | Type I transferrin isoform profile (HP:0003642) | 3.54033301 |
| 18 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.51135055 |
| 19 | Cerebral hypomyelination (HP:0006808) | 3.49904198 |
| 20 | Increased hepatocellular lipid droplets (HP:0006565) | 3.48135660 |
| 21 | Oral leukoplakia (HP:0002745) | 3.47635746 |
| 22 | Increased serum lactate (HP:0002151) | 3.42961809 |
| 23 | Acute encephalopathy (HP:0006846) | 3.26175613 |
| 24 | Rough bone trabeculation (HP:0100670) | 3.22260706 |
| 25 | 3-Methylglutaconic aciduria (HP:0003535) | 3.22129655 |
| 26 | Pallor (HP:0000980) | 3.14950740 |
| 27 | Lipid accumulation in hepatocytes (HP:0006561) | 3.12121213 |
| 28 | Abnormality of the labia minora (HP:0012880) | 2.97104261 |
| 29 | Microretrognathia (HP:0000308) | 2.90213213 |
| 30 | Progressive macrocephaly (HP:0004481) | 2.89286441 |
| 31 | Methylmalonic aciduria (HP:0012120) | 2.82034630 |
| 32 | Lactic acidosis (HP:0003128) | 2.80467531 |
| 33 | Methylmalonic acidemia (HP:0002912) | 2.77125058 |
| 34 | Carpal bone hypoplasia (HP:0001498) | 2.74729033 |
| 35 | Renal Fanconi syndrome (HP:0001994) | 2.74336036 |
| 36 | Reduced antithrombin III activity (HP:0001976) | 2.73330668 |
| 37 | Microvesicular hepatic steatosis (HP:0001414) | 2.68467384 |
| 38 | Increased intramyocellular lipid droplets (HP:0012240) | 2.65408856 |
| 39 | Exercise intolerance (HP:0003546) | 2.63136039 |
| 40 | CNS hypomyelination (HP:0003429) | 2.62833155 |
| 41 | Progressive muscle weakness (HP:0003323) | 2.59611114 |
| 42 | Exertional dyspnea (HP:0002875) | 2.59395026 |
| 43 | Patellar aplasia (HP:0006443) | 2.55685088 |
| 44 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.52850922 |
| 45 | Pancreatic cysts (HP:0001737) | 2.51571444 |
| 46 | Abnormality of the preputium (HP:0100587) | 2.51011490 |
| 47 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.48755180 |
| 48 | Respiratory difficulties (HP:0002880) | 2.48709007 |
| 49 | Abnormal protein glycosylation (HP:0012346) | 2.48561251 |
| 50 | Abnormal glycosylation (HP:0012345) | 2.48561251 |
| 51 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.48561251 |
| 52 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.48561251 |
| 53 | Type 2 muscle fiber atrophy (HP:0003554) | 2.44699315 |
| 54 | Abnormal trabecular bone morphology (HP:0100671) | 2.44212707 |
| 55 | Optic disc pallor (HP:0000543) | 2.43471599 |
| 56 | Premature graying of hair (HP:0002216) | 2.41801121 |
| 57 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.40754607 |
| 58 | Increased serum pyruvate (HP:0003542) | 2.39022104 |
| 59 | Abnormality of glycolysis (HP:0004366) | 2.39022104 |
| 60 | Respiratory failure (HP:0002878) | 2.38504363 |
| 61 | Abnormality of methionine metabolism (HP:0010901) | 2.38069033 |
| 62 | Leukodystrophy (HP:0002415) | 2.37129449 |
| 63 | Muscle fiber atrophy (HP:0100295) | 2.36546279 |
| 64 | CNS demyelination (HP:0007305) | 2.36535058 |
| 65 | Pancytopenia (HP:0001876) | 2.35388999 |
| 66 | Abnormality of serum amino acid levels (HP:0003112) | 2.35340079 |
| 67 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.34200177 |
| 68 | Molar tooth sign on MRI (HP:0002419) | 2.31977363 |
| 69 | Abnormality of midbrain morphology (HP:0002418) | 2.31977363 |
| 70 | Degeneration of anterior horn cells (HP:0002398) | 2.31402402 |
| 71 | Abnormality of the anterior horn cell (HP:0006802) | 2.31402402 |
| 72 | Lethargy (HP:0001254) | 2.30846253 |
| 73 | Colon cancer (HP:0003003) | 2.29334687 |
| 74 | Megaloblastic anemia (HP:0001889) | 2.28471210 |
| 75 | Hyperglycinemia (HP:0002154) | 2.28470491 |
| 76 | Bone marrow hypocellularity (HP:0005528) | 2.27202109 |
| 77 | Sparse eyelashes (HP:0000653) | 2.24620855 |
| 78 | Meckel diverticulum (HP:0002245) | 2.22741529 |
| 79 | Secondary amenorrhea (HP:0000869) | 2.21417613 |
| 80 | Cellular immunodeficiency (HP:0005374) | 2.20940799 |
| 81 | Chromsome breakage (HP:0040012) | 2.20172613 |
| 82 | Increased muscle lipid content (HP:0009058) | 2.20134066 |
| 83 | Emotional lability (HP:0000712) | 2.17885988 |
| 84 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.16799294 |
| 85 | Abnormality of the ileum (HP:0001549) | 2.15647522 |
| 86 | Cerebral edema (HP:0002181) | 2.14657404 |
| 87 | Premature ovarian failure (HP:0008209) | 2.12329601 |
| 88 | Abnormality of alanine metabolism (HP:0010916) | 2.11309004 |
| 89 | Hyperalaninemia (HP:0003348) | 2.11309004 |
| 90 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.11309004 |
| 91 | True hermaphroditism (HP:0010459) | 2.10865705 |
| 92 | Absent thumb (HP:0009777) | 2.08605699 |
| 93 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.07346235 |
| 94 | Thrombocytosis (HP:0001894) | 2.06114141 |
| 95 | Selective tooth agenesis (HP:0001592) | 2.03730802 |
| 96 | 11 pairs of ribs (HP:0000878) | 2.02842065 |
| 97 | IgM deficiency (HP:0002850) | 2.01022012 |
| 98 | Myelodysplasia (HP:0002863) | 2.00467645 |
| 99 | Horseshoe kidney (HP:0000085) | 1.99299016 |
| 100 | Abnormality of chromosome stability (HP:0003220) | 1.94297206 |
| 101 | Abnormal lung lobation (HP:0002101) | 1.92413681 |
| 102 | Abnormality of the duodenum (HP:0002246) | 1.91421117 |
| 103 | Triphalangeal thumb (HP:0001199) | 1.90449253 |
| 104 | Supernumerary spleens (HP:0009799) | 1.87868672 |
| 105 | Postnatal microcephaly (HP:0005484) | 1.87394261 |
| 106 | Hypoplasia of the pons (HP:0012110) | 1.87391544 |
| 107 | Cleft eyelid (HP:0000625) | 1.87298504 |
| 108 | Unsteady gait (HP:0002317) | 1.87157965 |
| 109 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.86655217 |
| 110 | Abnormal spermatogenesis (HP:0008669) | 1.86635579 |
| 111 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.86300010 |
| 112 | Abnormality of glycine metabolism (HP:0010895) | 1.86300010 |
| 113 | Hyperglycinuria (HP:0003108) | 1.86093059 |
| 114 | Glycosuria (HP:0003076) | 1.84520738 |
| 115 | Abnormality of urine glucose concentration (HP:0011016) | 1.84520738 |
| 116 | Abnormality of homocysteine metabolism (HP:0010919) | 1.84436364 |
| 117 | Homocystinuria (HP:0002156) | 1.84436364 |
| 118 | Abnormality of the pons (HP:0007361) | 1.83283033 |
| 119 | Multiple enchondromatosis (HP:0005701) | 1.83137251 |
| 120 | Abnormality of renal resorption (HP:0011038) | 1.81761220 |
| 121 | Impulsivity (HP:0100710) | 1.81411636 |
| 122 | Nephronophthisis (HP:0000090) | 1.81408312 |
| 123 | Petechiae (HP:0000967) | 1.81251965 |
| 124 | Congenital, generalized hypertrichosis (HP:0004540) | 1.80177730 |
| 125 | Medial flaring of the eyebrow (HP:0010747) | 1.80080345 |
| 126 | Duodenal stenosis (HP:0100867) | 1.79279849 |
| 127 | Small intestinal stenosis (HP:0012848) | 1.79279849 |
| 128 | Pancreatic fibrosis (HP:0100732) | 1.79164900 |
| 129 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.78898667 |
| 130 | Generalized aminoaciduria (HP:0002909) | 1.78845038 |
| 131 | Sloping forehead (HP:0000340) | 1.77061790 |
| 132 | Abnormal biliary tract physiology (HP:0012439) | 1.76477731 |
| 133 | Bile duct proliferation (HP:0001408) | 1.76477731 |
| 134 | Pendular nystagmus (HP:0012043) | 1.75745108 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.03596711 |
| 2 | WEE1 | 4.41628260 |
| 3 | STK16 | 3.77301485 |
| 4 | VRK2 | 3.75716591 |
| 5 | EIF2AK1 | 3.27213841 |
| 6 | NME2 | 3.11864816 |
| 7 | TSSK6 | 3.03853430 |
| 8 | SRPK1 | 2.99868848 |
| 9 | VRK1 | 2.63204246 |
| 10 | PLK4 | 2.53702401 |
| 11 | CDC7 | 2.52425582 |
| 12 | EIF2AK3 | 2.49468995 |
| 13 | NUAK1 | 2.32791532 |
| 14 | ACVR1B | 2.27819113 |
| 15 | BRSK2 | 2.20378276 |
| 16 | CCNB1 | 1.98396474 |
| 17 | MAP4K2 | 1.93058044 |
| 18 | NME1 | 1.84196039 |
| 19 | TRIM28 | 1.72233666 |
| 20 | WNK3 | 1.71241648 |
| 21 | PLK1 | 1.66591058 |
| 22 | MKNK1 | 1.65808491 |
| 23 | DYRK3 | 1.62226635 |
| 24 | ZAK | 1.59608643 |
| 25 | TTK | 1.51512304 |
| 26 | TAOK3 | 1.46811041 |
| 27 | IRAK3 | 1.45644614 |
| 28 | PDK2 | 1.43787647 |
| 29 | PLK3 | 1.42439904 |
| 30 | PIM2 | 1.41891044 |
| 31 | TLK1 | 1.41191074 |
| 32 | MKNK2 | 1.40785412 |
| 33 | NEK2 | 1.40569751 |
| 34 | NEK1 | 1.39865141 |
| 35 | PASK | 1.35526164 |
| 36 | KDR | 1.34777045 |
| 37 | AURKB | 1.34135289 |
| 38 | BRSK1 | 1.30891345 |
| 39 | TAF1 | 1.27018206 |
| 40 | ATR | 1.18625228 |
| 41 | AURKA | 1.16212588 |
| 42 | CDK7 | 1.15700600 |
| 43 | FRK | 1.12284421 |
| 44 | MUSK | 1.10562922 |
| 45 | EIF2AK2 | 1.06406137 |
| 46 | PNCK | 1.05914560 |
| 47 | EPHA2 | 1.04722051 |
| 48 | RPS6KB2 | 1.02775888 |
| 49 | BCKDK | 1.02302192 |
| 50 | TEC | 0.99853607 |
| 51 | IRAK4 | 0.99273291 |
| 52 | CHEK2 | 0.96533164 |
| 53 | MAP3K12 | 0.95296985 |
| 54 | CDK8 | 0.93486483 |
| 55 | CDK19 | 0.91589593 |
| 56 | TGFBR1 | 0.87960513 |
| 57 | TESK2 | 0.86819307 |
| 58 | BRAF | 0.86632785 |
| 59 | CSNK1G1 | 0.82089885 |
| 60 | MST4 | 0.81323796 |
| 61 | OXSR1 | 0.79447001 |
| 62 | CSNK2A1 | 0.79233108 |
| 63 | CSNK2A2 | 0.78049462 |
| 64 | PBK | 0.72760441 |
| 65 | WNK4 | 0.71738214 |
| 66 | PLK2 | 0.71490409 |
| 67 | TIE1 | 0.70503698 |
| 68 | MAP3K4 | 0.68735855 |
| 69 | FLT3 | 0.65411397 |
| 70 | CSNK1G2 | 0.65287854 |
| 71 | BMPR1B | 0.63504588 |
| 72 | STK3 | 0.63214898 |
| 73 | MAP3K8 | 0.63011636 |
| 74 | CHEK1 | 0.62713732 |
| 75 | INSRR | 0.59479294 |
| 76 | DAPK1 | 0.59212534 |
| 77 | PINK1 | 0.58801779 |
| 78 | DYRK2 | 0.57972674 |
| 79 | PRKCI | 0.57531748 |
| 80 | MYLK | 0.54791982 |
| 81 | PIM1 | 0.54723742 |
| 82 | CSNK1A1L | 0.54355410 |
| 83 | RPS6KA4 | 0.53606797 |
| 84 | RPS6KA5 | 0.52955673 |
| 85 | CASK | 0.52858578 |
| 86 | BTK | 0.52530644 |
| 87 | TXK | 0.52251866 |
| 88 | ERBB3 | 0.51037437 |
| 89 | CDK4 | 0.49249945 |
| 90 | ARAF | 0.49170539 |
| 91 | PAK4 | 0.48439650 |
| 92 | STK39 | 0.47535749 |
| 93 | BCR | 0.47454269 |
| 94 | LIMK1 | 0.47247624 |
| 95 | AKT3 | 0.46867077 |
| 96 | MAP2K6 | 0.45830964 |
| 97 | ALK | 0.45500334 |
| 98 | ATM | 0.44558886 |
| 99 | CDK2 | 0.44184282 |
| 100 | CSNK1G3 | 0.43919971 |
| 101 | PRKCG | 0.43419639 |
| 102 | MAP4K1 | 0.42870716 |
| 103 | KIT | 0.41887032 |
| 104 | ILK | 0.41028790 |
| 105 | STK24 | 0.40732053 |
| 106 | PAK1 | 0.39985993 |
| 107 | STK4 | 0.38929521 |
| 108 | PDK4 | 0.38282621 |
| 109 | PDK3 | 0.38282621 |
| 110 | MAP3K11 | 0.36885909 |
| 111 | MAP2K7 | 0.35770264 |
| 112 | CAMKK2 | 0.35189537 |
| 113 | ADRBK2 | 0.34930946 |
| 114 | TNIK | 0.34457651 |
| 115 | PIK3CG | 0.34145948 |
| 116 | ABL2 | 0.32513350 |
| 117 | ZAP70 | 0.32455788 |
| 118 | CDK1 | 0.31567407 |
| 119 | STK38L | 0.30827229 |
| 120 | PHKG1 | 0.30504368 |
| 121 | PHKG2 | 0.30504368 |
| 122 | FGFR1 | 0.29954355 |
| 123 | YES1 | 0.28984701 |
| 124 | MAP2K3 | 0.28890703 |
| 125 | GRK1 | 0.28346651 |
| 126 | SCYL2 | 0.28337416 |
| 127 | MAPKAPK5 | 0.27078228 |
| 128 | LYN | 0.26975594 |
| 129 | CSNK1E | 0.23760296 |
| 130 | SYK | 0.22899403 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.61288983 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.52372825 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 4.44397099 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 4.14582682 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.62129359 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.46443791 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.93515114 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.84075513 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.77955609 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.63130284 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.56231125 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.50604368 |
| 13 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.14022461 |
| 14 | Protein export_Homo sapiens_hsa03060 | 2.07851272 |
| 15 | Parkinsons disease_Homo sapiens_hsa05012 | 2.01295086 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.98243969 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 1.92775365 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.91914215 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.86388141 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.81222031 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.76409023 |
| 22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.74052039 |
| 23 | Purine metabolism_Homo sapiens_hsa00230 | 1.72406842 |
| 24 | * RNA degradation_Homo sapiens_hsa03018 | 1.66079699 |
| 25 | Huntingtons disease_Homo sapiens_hsa05016 | 1.62562522 |
| 26 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.57499823 |
| 27 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.51278472 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.45675801 |
| 29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.41273542 |
| 30 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.19693272 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.18227512 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.17890956 |
| 33 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.07020582 |
| 34 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.02590580 |
| 35 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.98876032 |
| 36 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.97688536 |
| 37 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.96804066 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.95409832 |
| 39 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.94331342 |
| 40 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.92340111 |
| 41 | Sulfur relay system_Homo sapiens_hsa04122 | 0.88952299 |
| 42 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.88796183 |
| 43 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.87881854 |
| 44 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.84936091 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.81977694 |
| 46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.80709539 |
| 47 | Phototransduction_Homo sapiens_hsa04744 | 0.79585994 |
| 48 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.78097447 |
| 49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.75621197 |
| 50 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.69865512 |
| 51 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.69607167 |
| 52 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67804171 |
| 53 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.67670241 |
| 54 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.66077350 |
| 55 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.65913656 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.60692759 |
| 57 | Carbon metabolism_Homo sapiens_hsa01200 | 0.60556228 |
| 58 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.60512604 |
| 59 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.59513178 |
| 60 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.58715600 |
| 61 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.56917605 |
| 62 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.55428243 |
| 63 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.54147542 |
| 64 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.51284674 |
| 65 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.49879376 |
| 66 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.49173435 |
| 67 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.48088882 |
| 68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.47995289 |
| 69 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.47789388 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.46548742 |
| 71 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.46127396 |
| 72 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.46113744 |
| 73 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.43098066 |
| 74 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.42125033 |
| 75 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.40215315 |
| 76 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.39870384 |
| 77 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.39237970 |
| 78 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.39003320 |
| 79 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.37131551 |
| 80 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.36005665 |
| 81 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.34791398 |
| 82 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.34538538 |
| 83 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.34131458 |
| 84 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.32953246 |
| 85 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.32665879 |
| 86 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.31524974 |
| 87 | Galactose metabolism_Homo sapiens_hsa00052 | 0.31084556 |
| 88 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.30574167 |
| 89 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.28126045 |
| 90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.27420318 |
| 91 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.26782292 |
| 92 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.25033972 |
| 93 | Olfactory transduction_Homo sapiens_hsa04740 | 0.24859572 |
| 94 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.24592064 |
| 95 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.23745791 |
| 96 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.23032203 |
| 97 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.22993047 |
| 98 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.20406181 |
| 99 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.19868946 |
| 100 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.16593117 |
| 101 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.16423086 |
| 102 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.14284579 |
| 103 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.14150648 |
| 104 | HTLV-I infection_Homo sapiens_hsa05166 | 0.13861846 |
| 105 | Legionellosis_Homo sapiens_hsa05134 | 0.13838059 |
| 106 | Thyroid cancer_Homo sapiens_hsa05216 | 0.12981122 |
| 107 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.11202561 |
| 108 | Peroxisome_Homo sapiens_hsa04146 | 0.10543006 |
| 109 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.09965284 |
| 110 | Alcoholism_Homo sapiens_hsa05034 | 0.09332470 |
| 111 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.09167644 |
| 112 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.09159598 |
| 113 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.08937045 |
| 114 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.07630942 |
| 115 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.06947070 |
| 116 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.05819653 |
| 117 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.05099379 |
| 118 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.04883397 |
| 119 | Retinol metabolism_Homo sapiens_hsa00830 | 0.02525536 |
| 120 | Measles_Homo sapiens_hsa05162 | 0.00796762 |
| 121 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.00707709 |
| 122 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.00380137 |
| 123 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | -0.0043203 |

