EXOSC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.39830525
2ribosomal small subunit assembly (GO:0000028)5.15192829
3DNA strand elongation involved in DNA replication (GO:0006271)4.95648986
4telomere maintenance via semi-conservative replication (GO:0032201)4.86406372
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.77270457
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.77036472
7ATP synthesis coupled proton transport (GO:0015986)4.77036472
8DNA strand elongation (GO:0022616)4.73581479
9DNA replication initiation (GO:0006270)4.58414178
10chaperone-mediated protein transport (GO:0072321)4.47554478
11maturation of SSU-rRNA (GO:0030490)4.44960756
12telomere maintenance via recombination (GO:0000722)4.43276198
13DNA replication checkpoint (GO:0000076)4.39424193
14DNA deamination (GO:0045006)4.33145359
15CENP-A containing nucleosome assembly (GO:0034080)4.30067271
16chromatin remodeling at centromere (GO:0031055)4.18985202
17mitotic recombination (GO:0006312)4.18585281
18mitotic metaphase plate congression (GO:0007080)4.15624759
19viral transcription (GO:0019083)4.07363412
20protein localization to kinetochore (GO:0034501)4.06658165
21ribosomal small subunit biogenesis (GO:0042274)4.06376996
22kinetochore organization (GO:0051383)4.06335045
23translational termination (GO:0006415)4.02778341
24DNA double-strand break processing (GO:0000729)3.97276453
25formation of translation preinitiation complex (GO:0001731)3.94149030
26DNA unwinding involved in DNA replication (GO:0006268)3.93816722
27telomere maintenance via telomere lengthening (GO:0010833)3.91231765
28nucleobase biosynthetic process (GO:0046112)3.90799386
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.89783779
30ribosomal large subunit biogenesis (GO:0042273)3.88127453
31protein complex biogenesis (GO:0070271)3.86377662
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.79945349
33mitochondrial respiratory chain complex assembly (GO:0033108)3.78455762
34* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.77125990
35* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.76090111
36protein neddylation (GO:0045116)3.75986679
37DNA replication-independent nucleosome organization (GO:0034724)3.75954611
38DNA replication-independent nucleosome assembly (GO:0006336)3.75954611
39proteasome assembly (GO:0043248)3.75051262
40kinetochore assembly (GO:0051382)3.73836841
41metaphase plate congression (GO:0051310)3.72974007
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.72159511
43NADH dehydrogenase complex assembly (GO:0010257)3.72159511
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72159511
45purine nucleobase biosynthetic process (GO:0009113)3.69234869
46ribonucleoprotein complex biogenesis (GO:0022613)3.68970637
47translational elongation (GO:0006414)3.65700722
48respiratory electron transport chain (GO:0022904)3.64319208
49protein localization to chromosome, centromeric region (GO:0071459)3.60916766
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60228721
51regulation of mitotic spindle checkpoint (GO:1903504)3.60228721
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.59361301
53electron transport chain (GO:0022900)3.57930877
54attachment of spindle microtubules to kinetochore (GO:0008608)3.56911424
55translational initiation (GO:0006413)3.54593956
56ribosome biogenesis (GO:0042254)3.53067950
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51943689
58mitotic nuclear envelope disassembly (GO:0007077)3.51548732
59SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50371779
60regulation of mitochondrial translation (GO:0070129)3.49772216
61establishment of chromosome localization (GO:0051303)3.45596412
62histone exchange (GO:0043486)3.45554744
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45533462
64spliceosomal snRNP assembly (GO:0000387)3.44380065
65ribosome assembly (GO:0042255)3.43156867
66cotranslational protein targeting to membrane (GO:0006613)3.42933454
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42545045
68respiratory chain complex IV assembly (GO:0008535)3.40448002
69DNA ligation (GO:0006266)3.40335433
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39836707
71transcription-coupled nucleotide-excision repair (GO:0006283)3.39814361
72cullin deneddylation (GO:0010388)3.39668091
73* rRNA processing (GO:0006364)3.39554988
74protein targeting to ER (GO:0045047)3.39269455
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38199632
76DNA catabolic process, exonucleolytic (GO:0000738)3.36941780
77IMP biosynthetic process (GO:0006188)3.36478381
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35392914
79replication fork processing (GO:0031297)3.34417815
80DNA replication-dependent nucleosome organization (GO:0034723)3.33979301
81DNA replication-dependent nucleosome assembly (GO:0006335)3.33979301
82protein K6-linked ubiquitination (GO:0085020)3.33485114
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32102166
84pseudouridine synthesis (GO:0001522)3.30562502
85protein-cofactor linkage (GO:0018065)3.27999685
86* rRNA metabolic process (GO:0016072)3.27860785
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27056298
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27056298
89rRNA modification (GO:0000154)3.25108590
90mitotic chromosome condensation (GO:0007076)3.24682610
91protein deneddylation (GO:0000338)3.21424949
92protein localization to endoplasmic reticulum (GO:0070972)3.20720602
93nuclear envelope disassembly (GO:0051081)3.20623211
94membrane disassembly (GO:0030397)3.20623211
95cytochrome complex assembly (GO:0017004)3.20480036
96establishment of protein localization to endoplasmic reticulum (GO:0072599)3.20164844
97cell cycle G1/S phase transition (GO:0044843)3.19444970
98G1/S transition of mitotic cell cycle (GO:0000082)3.19444970
99cellular protein complex disassembly (GO:0043624)3.18947578
100spliceosomal complex assembly (GO:0000245)3.17886568
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15401311
102negative regulation of ligase activity (GO:0051352)3.15401311
103viral life cycle (GO:0019058)3.14745819
104mitotic sister chromatid segregation (GO:0000070)3.13287709
105regulation of cellular amino acid metabolic process (GO:0006521)3.12848521
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12165099
107telomere organization (GO:0032200)3.10909913
108viral mRNA export from host cell nucleus (GO:0046784)3.10902791
109telomere maintenance (GO:0000723)3.10447351
110meiotic chromosome segregation (GO:0045132)3.10421199
111DNA damage response, detection of DNA damage (GO:0042769)3.09416229
112regulation of double-strand break repair via homologous recombination (GO:0010569)3.09205902
113termination of RNA polymerase III transcription (GO:0006386)3.08164855
114transcription elongation from RNA polymerase III promoter (GO:0006385)3.08164855
115translation (GO:0006412)3.07021238
116establishment of integrated proviral latency (GO:0075713)3.06471835
1177-methylguanosine mRNA capping (GO:0006370)3.06136111
118regulation of spindle organization (GO:0090224)3.04594847
119water-soluble vitamin biosynthetic process (GO:0042364)3.04519187
120histone mRNA metabolic process (GO:0008334)3.02182520
121RNA capping (GO:0036260)3.01371656
1227-methylguanosine RNA capping (GO:0009452)3.01371656
123nuclear pore organization (GO:0006999)3.01344638
124DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01222898
125IMP metabolic process (GO:0046040)3.00932141
126rRNA methylation (GO:0031167)2.99988733
127positive regulation of ligase activity (GO:0051351)2.99329079
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98615684
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98615684
130signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97915624
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97915624
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97915624
133maturation of 5.8S rRNA (GO:0000460)2.97618188
134recombinational repair (GO:0000725)2.97553159
135termination of RNA polymerase I transcription (GO:0006363)2.94955863
136spindle checkpoint (GO:0031577)2.94323633
137double-strand break repair via homologous recombination (GO:0000724)2.94094049
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93475759
139signal transduction involved in DNA damage checkpoint (GO:0072422)2.93475759
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91063007
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.90381706
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.89402057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.38357239
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.30962367
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.81647991
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79856625
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72872132
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.66912259
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.33899663
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25891795
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.21944622
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08019556
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.96803559
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92651762
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89893272
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88555238
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84634457
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58845257
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52055872
18VDR_23849224_ChIP-Seq_CD4+_Human2.46621476
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46153149
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38733566
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36283303
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35886798
23XRN2_22483619_ChIP-Seq_HELA_Human2.35726356
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.16223497
25DCP1A_22483619_ChIP-Seq_HELA_Human2.12059195
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07797431
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05935163
28AR_21909140_ChIP-Seq_LNCAP_Human2.04622430
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04477077
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01372731
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97670533
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.95669432
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94964306
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94193688
35TTF2_22483619_ChIP-Seq_HELA_Human1.93622497
36GABP_19822575_ChIP-Seq_HepG2_Human1.92909565
37ZNF274_21170338_ChIP-Seq_K562_Hela1.88864580
38ELK1_19687146_ChIP-ChIP_HELA_Human1.87683884
39VDR_22108803_ChIP-Seq_LS180_Human1.83066612
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83011792
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82768765
42EWS_26573619_Chip-Seq_HEK293_Human1.82591369
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77395070
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71414414
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71152811
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.70370802
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68103652
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66489084
49CIITA_25753668_ChIP-Seq_RAJI_Human1.64676958
50* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63180761
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.63164744
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.60600853
53FUS_26573619_Chip-Seq_HEK293_Human1.56557329
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56337744
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52464451
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.51970694
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50483187
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49446654
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48241411
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47672919
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47222852
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41479063
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40783511
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40085398
65KDM5A_27292631_Chip-Seq_BREAST_Human1.37895338
66IGF1R_20145208_ChIP-Seq_DFB_Human1.35922903
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30156386
68MYC_22102868_ChIP-Seq_BL_Human1.29033099
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.28538909
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.26227839
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26095381
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24128850
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23847259
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23524636
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.22369638
76IRF1_19129219_ChIP-ChIP_H3396_Human1.22117802
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21165313
78* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20387306
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.18932480
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.16682997
81* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15247285
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13282946
83* SPI1_23547873_ChIP-Seq_NB4_Human1.11341647
84MYC_18940864_ChIP-ChIP_HL60_Human1.11283876
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08856089
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07593056
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06514098
88P300_19829295_ChIP-Seq_ESCs_Human1.03106681
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01331240
90TFEB_21752829_ChIP-Seq_HELA_Human1.01295661
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99886938
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97304740
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96855281
94TAF15_26573619_Chip-Seq_HEK293_Human0.96415929
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.95808868
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95655772
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95186833
98SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94553602
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94413848
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93001136
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92931663
102CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92304999
103ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92262039
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91276184
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90964367
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90711100
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89869928
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89346571
109VDR_21846776_ChIP-Seq_THP-1_Human0.89148115
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88403481
111TP53_22573176_ChIP-Seq_HFKS_Human0.86761123
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86658506
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82071579
114CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80377422
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79391677
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79119523
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78273638
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77815065
119FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76475487
120FOXA1_25329375_ChIP-Seq_VCAP_Human0.76475487
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75029589
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74762248
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74634129
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74613264
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73760115
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73684999
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72734973
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.72457465
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72202387
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.71888713
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71070551
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.70938971
133MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.70808255
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68044495
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.67193078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53254099
2MP0010094_abnormal_chromosome_stability4.88564756
3MP0004957_abnormal_blastocyst_morpholog4.54072578
4MP0003111_abnormal_nucleus_morphology4.50783508
5MP0008057_abnormal_DNA_replication4.45531478
6MP0003077_abnormal_cell_cycle4.07924638
7MP0008058_abnormal_DNA_repair3.76804039
8MP0002396_abnormal_hematopoietic_system3.00359475
9MP0008007_abnormal_cellular_replicative2.96165852
10MP0008932_abnormal_embryonic_tissue2.64958927
11MP0008877_abnormal_DNA_methylation2.45796757
12MP0006072_abnormal_retinal_apoptosis2.34883490
13MP0003123_paternal_imprinting2.30211301
14MP0003786_premature_aging2.20824564
15MP0003136_yellow_coat_color2.11796169
16MP0001730_embryonic_growth_arrest2.01425234
17MP0000350_abnormal_cell_proliferation1.99261508
18MP0001529_abnormal_vocalization1.96271511
19MP0000490_abnormal_crypts_of1.90775788
20MP0003763_abnormal_thymus_physiology1.80479988
21MP0000372_irregular_coat_pigmentation1.73505299
22MP0008789_abnormal_olfactory_epithelium1.71821239
23MP0009333_abnormal_splenocyte_physiolog1.71049837
24MP0003718_maternal_effect1.70554342
25MP0004808_abnormal_hematopoietic_stem1.64148060
26MP0002736_abnormal_nociception_after1.62611750
27MP0005084_abnormal_gallbladder_morpholo1.60310352
28MP0002837_dystrophic_cardiac_calcinosis1.57300743
29MP0002019_abnormal_tumor_incidence1.52202947
30MP0000313_abnormal_cell_death1.49917547
31MP0008995_early_reproductive_senescence1.49669925
32MP0001697_abnormal_embryo_size1.48760150
33MP0002398_abnormal_bone_marrow1.47795404
34MP0001672_abnormal_embryogenesis/_devel1.44635794
35MP0005380_embryogenesis_phenotype1.44635794
36MP0005397_hematopoietic_system_phenotyp1.42509525
37MP0001545_abnormal_hematopoietic_system1.42509525
38MP0002132_abnormal_respiratory_system1.41944680
39MP0005253_abnormal_eye_physiology1.38955996
40MP0002080_prenatal_lethality1.38185424
41MP0000703_abnormal_thymus_morphology1.35015231
42MP0009379_abnormal_foot_pigmentation1.33510452
43MP0002722_abnormal_immune_system1.33090261
44MP0003787_abnormal_imprinting1.32086990
45MP0003984_embryonic_growth_retardation1.31514683
46MP0003011_delayed_dark_adaptation1.30997007
47MP0003315_abnormal_perineum_morphology1.30736990
48MP0003121_genomic_imprinting1.30523848
49MP0000689_abnormal_spleen_morphology1.30372687
50MP0001835_abnormal_antigen_presentation1.28991428
51MP0002088_abnormal_embryonic_growth/wei1.27299374
52MP0010307_abnormal_tumor_latency1.27233028
53MP0003567_abnormal_fetal_cardiomyocyte1.26209803
54MP0010352_gastrointestinal_tract_polyps1.25850781
55MP0000631_abnormal_neuroendocrine_gland1.24677473
56MP0005671_abnormal_response_to1.21976340
57MP0003937_abnormal_limbs/digits/tail_de1.21168163
58MP0006054_spinal_hemorrhage1.20884754
59MP0004133_heterotaxia1.20355005
60MP0001485_abnormal_pinna_reflex1.19759862
61MP0005394_taste/olfaction_phenotype1.19587138
62MP0005499_abnormal_olfactory_system1.19587138
63MP0002210_abnormal_sex_determination1.18989486
64MP0002638_abnormal_pupillary_reflex1.16370323
65MP0003880_abnormal_central_pattern1.15097265
66MP0002429_abnormal_blood_cell1.14841290
67MP0002085_abnormal_embryonic_tissue1.14267436
68MP0002277_abnormal_respiratory_mucosa1.12899899
69MP0001853_heart_inflammation1.12367496
70MP0005551_abnormal_eye_electrophysiolog1.12245927
71MP0002086_abnormal_extraembryonic_tissu1.12061674
72MP0005075_abnormal_melanosome_morpholog1.11894503
73MP0001286_abnormal_eye_development1.11664034
74MP0001968_abnormal_touch/_nociception1.11375939
75MP0003186_abnormal_redox_activity1.10034415
76MP0001984_abnormal_olfaction1.09884151
77MP0006292_abnormal_olfactory_placode1.08599296
78MP0004142_abnormal_muscle_tone1.08298705
79MP0009697_abnormal_copulation1.08251839
80MP0000716_abnormal_immune_system1.06188538
81MP0004147_increased_porphyrin_level1.04540050
82MP0003806_abnormal_nucleotide_metabolis1.02648347
83MP0008872_abnormal_physiological_respon1.02292371
84MP0001145_abnormal_male_reproductive1.01891531
85MP0003941_abnormal_skin_development1.01832029
86MP0002751_abnormal_autonomic_nervous1.01704366
87MP0010030_abnormal_orbit_morphology1.01223077
88MP0001800_abnormal_humoral_immune1.00137361
89MP0005645_abnormal_hypothalamus_physiol1.00118161
90MP0001188_hyperpigmentation0.97681350
91MP0004197_abnormal_fetal_growth/weight/0.96299377
92MP0002234_abnormal_pharynx_morphology0.96032469
93MP0002420_abnormal_adaptive_immunity0.95935148
94MP0001819_abnormal_immune_cell0.93945856
95MP0001293_anophthalmia0.92345931
96MP0006036_abnormal_mitochondrial_physio0.91362636
97MP0002084_abnormal_developmental_patter0.91073958
98MP0002233_abnormal_nose_morphology0.90074758
99MP0005391_vision/eye_phenotype0.89652401
100MP0000049_abnormal_middle_ear0.89398502
101MP0001929_abnormal_gametogenesis0.89210571
102MP0001119_abnormal_female_reproductive0.89160969
103MP0002452_abnormal_antigen_presenting0.88824190
104MP0000653_abnormal_sex_gland0.88430546
105MP0000858_altered_metastatic_potential0.88049360
106MP0003119_abnormal_digestive_system0.87176265
107MP0002095_abnormal_skin_pigmentation0.86899520
108MP0003698_abnormal_male_reproductive0.86086383
109MP0000685_abnormal_immune_system0.85913518
110MP0003195_calcinosis0.84438461
111MP0004215_abnormal_myocardial_fiber0.84210951
112MP0000358_abnormal_cell_content/0.83933071
113MP0003122_maternal_imprinting0.82590518
114MP0000647_abnormal_sebaceous_gland0.81533072
115MP0002723_abnormal_immune_serum0.80869745
116MP0002653_abnormal_ependyma_morphology0.80786562
117MP0000465_gastrointestinal_hemorrhage0.78377356
118MP0002006_tumorigenesis0.78335202
119MP0006035_abnormal_mitochondrial_morpho0.78207642
120MP0003938_abnormal_ear_development0.77544862
121MP0002405_respiratory_system_inflammati0.76291213
122MP0000015_abnormal_ear_pigmentation0.76226744
123MP0005646_abnormal_pituitary_gland0.76113313
124MP0002111_abnormal_tail_morphology0.75056985
125MP0002160_abnormal_reproductive_system0.74420031
126MP0002166_altered_tumor_susceptibility0.73127571
127MP0005384_cellular_phenotype0.73118740
128MP0002697_abnormal_eye_size0.72654132
129MP0005174_abnormal_tail_pigmentation0.72512357
130MP0001346_abnormal_lacrimal_gland0.72443725
131MP0006276_abnormal_autonomic_nervous0.72028985
132MP0005195_abnormal_posterior_eye0.70040784
133MP0005389_reproductive_system_phenotype0.69789019
134MP0000566_synostosis0.68068866
135MP0003221_abnormal_cardiomyocyte_apopto0.67858878
136MP0002938_white_spotting0.67052186
137MP0005379_endocrine/exocrine_gland_phen0.66864319
138MP0009785_altered_susceptibility_to0.66618624
139MP0005000_abnormal_immune_tolerance0.65202367
140MP0005025_abnormal_response_to0.65049663
141MP0002282_abnormal_trachea_morphology0.64978498
142MP0002148_abnormal_hypersensitivity_rea0.64317653
143MP0001915_intracranial_hemorrhage0.63069928
144MP0003890_abnormal_embryonic-extraembry0.63053133
145MP0005621_abnormal_cell_physiology0.61931356
146MP0002102_abnormal_ear_morphology0.61262832
147MP0003656_abnormal_erythrocyte_physiolo0.61071170
148MP0001764_abnormal_homeostasis0.60778137
149MP0010155_abnormal_intestine_physiology0.56938006
150MP0002163_abnormal_gland_morphology0.56782437
151MP0001919_abnormal_reproductive_system0.56506535
152MP0003943_abnormal_hepatobiliary_system0.55455025

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.29603918
2Abnormality of cells of the erythroid lineage (HP:0012130)4.96579099
3Abnormal number of erythroid precursors (HP:0012131)4.83205285
4Reticulocytopenia (HP:0001896)4.82139345
5Acute necrotizing encephalopathy (HP:0006965)4.41084124
6Acute encephalopathy (HP:0006846)4.00317983
7Chromsome breakage (HP:0040012)3.91483063
8Breast hypoplasia (HP:0003187)3.90936766
9Abnormal mitochondria in muscle tissue (HP:0008316)3.85036040
10Progressive macrocephaly (HP:0004481)3.69272200
11Abnormality of the labia minora (HP:0012880)3.65924635
12Aplastic anemia (HP:0001915)3.64792399
13Oral leukoplakia (HP:0002745)3.59732961
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57601994
15Colon cancer (HP:0003003)3.41836096
16Patellar aplasia (HP:0006443)3.19578919
17Abnormality of the preputium (HP:0100587)3.17200007
18Macrocytic anemia (HP:0001972)3.16646226
19Meckel diverticulum (HP:0002245)3.15682852
20Abnormality of chromosome stability (HP:0003220)3.09521287
21Hepatic necrosis (HP:0002605)3.07977321
22Pallor (HP:0000980)3.03986830
23Abnormality of the ileum (HP:0001549)3.03663573
24Rough bone trabeculation (HP:0100670)3.03267806
25Aplasia/Hypoplasia of the patella (HP:0006498)3.02718589
26Abnormality of the anterior horn cell (HP:0006802)3.00125880
27Degeneration of anterior horn cells (HP:0002398)3.00125880
28Cerebral edema (HP:0002181)2.97574961
2911 pairs of ribs (HP:0000878)2.88785849
30Selective tooth agenesis (HP:0001592)2.88642640
31Myelodysplasia (HP:0002863)2.84913104
32Septo-optic dysplasia (HP:0100842)2.84533357
33Thrombocytosis (HP:0001894)2.83380210
34Cerebral hypomyelination (HP:0006808)2.82528991
35Renal Fanconi syndrome (HP:0001994)2.80380152
36Methylmalonic acidemia (HP:0002912)2.79785305
37Carpal bone hypoplasia (HP:0001498)2.79370342
38Premature graying of hair (HP:0002216)2.76740377
39Microretrognathia (HP:0000308)2.71911958
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.69952727
41Pancreatic cysts (HP:0001737)2.67222731
42Absent thumb (HP:0009777)2.67197909
43Abnormal lung lobation (HP:0002101)2.65935244
44Bone marrow hypocellularity (HP:0005528)2.64865234
45Agnosia (HP:0010524)2.63841117
46IgM deficiency (HP:0002850)2.63501311
47Small intestinal stenosis (HP:0012848)2.58901216
48Duodenal stenosis (HP:0100867)2.58901216
49Congenital, generalized hypertrichosis (HP:0004540)2.58293955
50Pancreatic fibrosis (HP:0100732)2.54914423
51Type I transferrin isoform profile (HP:0003642)2.51722340
52Molar tooth sign on MRI (HP:0002419)2.49895915
53Abnormality of midbrain morphology (HP:0002418)2.49895915
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48107024
55Medulloblastoma (HP:0002885)2.45070133
56True hermaphroditism (HP:0010459)2.43446429
57Hyperglycinemia (HP:0002154)2.42450895
58Lactic acidosis (HP:0003128)2.36739496
59Cellular immunodeficiency (HP:0005374)2.34250908
60Methylmalonic aciduria (HP:0012120)2.33057383
61Multiple enchondromatosis (HP:0005701)2.32974746
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.28199658
633-Methylglutaconic aciduria (HP:0003535)2.27768415
64Optic disc pallor (HP:0000543)2.27379589
65Absent radius (HP:0003974)2.26274904
66Abnormal trabecular bone morphology (HP:0100671)2.26102588
67Pancytopenia (HP:0001876)2.25493241
68Lymphoma (HP:0002665)2.25187208
69Impulsivity (HP:0100710)2.20144035
70Duplicated collecting system (HP:0000081)2.19210983
71Increased serum lactate (HP:0002151)2.18012833
72Triphalangeal thumb (HP:0001199)2.17208176
73Respiratory failure (HP:0002878)2.16210961
74Hypoplasia of the pons (HP:0012110)2.15121684
75Increased hepatocellular lipid droplets (HP:0006565)2.14838666
76Horseshoe kidney (HP:0000085)2.13912917
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12763131
78Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12763131
79Neoplasm of the pancreas (HP:0002894)2.12749108
80Increased intramyocellular lipid droplets (HP:0012240)2.12212437
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11458707
82Abnormal number of incisors (HP:0011064)2.11060804
83Leukodystrophy (HP:0002415)2.10993297
84Cleft eyelid (HP:0000625)2.10702607
85Sloping forehead (HP:0000340)2.10410953
86Nephronophthisis (HP:0000090)2.08520108
87Abnormality of methionine metabolism (HP:0010901)2.08196374
88Abnormality of the duodenum (HP:0002246)2.07887948
89Absent forearm bone (HP:0003953)2.06826055
90Aplasia involving forearm bones (HP:0009822)2.06826055
91Absent septum pellucidum (HP:0001331)2.06208879
92Tracheoesophageal fistula (HP:0002575)2.06139172
93Abnormality of the pons (HP:0007361)2.06049624
94Respiratory difficulties (HP:0002880)2.05944674
95Pendular nystagmus (HP:0012043)2.05346803
96Exertional dyspnea (HP:0002875)2.04326365
97Exercise intolerance (HP:0003546)2.04209833
98Ectopic kidney (HP:0000086)2.03781763
99Volvulus (HP:0002580)2.03164313
100Petechiae (HP:0000967)2.02775990
101Lethargy (HP:0001254)2.01699406
102Medial flaring of the eyebrow (HP:0010747)2.01129874
103Abnormality of serum amino acid levels (HP:0003112)2.00608310
104Premature ovarian failure (HP:0008209)2.00521190
105Secondary amenorrhea (HP:0000869)1.98000109
106Trismus (HP:0000211)1.97462647
107Abnormality of the renal collecting system (HP:0004742)1.97378858
108Atresia of the external auditory canal (HP:0000413)1.96595209
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95834810
110Hepatocellular necrosis (HP:0001404)1.95601483
111Microvesicular hepatic steatosis (HP:0001414)1.95363270
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94749747
113Clubbing of toes (HP:0100760)1.93080723
114Sclerocornea (HP:0000647)1.92310973
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91789998
116Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91248716
117Amaurosis fugax (HP:0100576)1.90663740
118Increased CSF lactate (HP:0002490)1.87304192
119IgG deficiency (HP:0004315)1.86951355
120Abnormality of the carotid arteries (HP:0005344)1.86366783
121Nephroblastoma (Wilms tumor) (HP:0002667)1.86318249
122Abnormality of serine family amino acid metabolism (HP:0010894)1.86276616
123Abnormality of glycine metabolism (HP:0010895)1.86276616
124Stenosis of the external auditory canal (HP:0000402)1.84324879
125Hyperglycinuria (HP:0003108)1.84253891
126Mitochondrial inheritance (HP:0001427)1.84151800
127Increased serum pyruvate (HP:0003542)1.84147502
128Muscle fiber atrophy (HP:0100295)1.83548623
129Rhabdomyosarcoma (HP:0002859)1.83525716
130Basal cell carcinoma (HP:0002671)1.83511985
131Pulmonary fibrosis (HP:0002206)1.82973324
132Abnormal spermatogenesis (HP:0008669)1.82238414
133Abnormality of renal resorption (HP:0011038)1.82221985
134Abnormality of the septum pellucidum (HP:0007375)1.81053363
135Abnormality of reticulocytes (HP:0004312)1.80758537
136Short thumb (HP:0009778)1.80669722
137Squamous cell carcinoma (HP:0002860)1.80538809
138Poor head control (HP:0002421)1.78298467
139Lipid accumulation in hepatocytes (HP:0006561)1.77628756
140Supernumerary spleens (HP:0009799)1.77440115
141Oligodactyly (hands) (HP:0001180)1.77172502
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76857035
143Reduced antithrombin III activity (HP:0001976)1.75758636
144Type 2 muscle fiber atrophy (HP:0003554)1.75645719
145Glossoptosis (HP:0000162)1.75184898
146Abnormality of DNA repair (HP:0003254)1.73444491
147Optic nerve hypoplasia (HP:0000609)1.72733535
148Megaloblastic anemia (HP:0001889)1.72448387
149Bile duct proliferation (HP:0001408)1.72178828
150Abnormal biliary tract physiology (HP:0012439)1.72178828
151CNS demyelination (HP:0007305)1.67064673
152Increased muscle lipid content (HP:0009058)1.66831815
153Abnormal glycosylation (HP:0012345)1.65903004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.67755176
2WEE14.03209092
3VRK23.97928541
4CDC73.79781459
5EIF2AK13.45567458
6STK162.85670166
7SRPK12.81111414
8PLK42.62944545
9NME22.52545267
10ACVR1B2.36185854
11VRK12.32530843
12MKNK12.31012845
13TSSK62.29816378
14BRSK22.24181415
15EIF2AK32.23504862
16WNK32.15803293
17NEK22.15468190
18TTK2.01989981
19PLK11.94553143
20TLK11.85180251
21BMPR1B1.78280666
22NEK11.74106284
23TAF11.70731216
24AURKB1.66513255
25ATR1.64393740
26PASK1.63964072
27CCNB11.60337238
28CDK71.58848341
29TNIK1.53545767
30TRIM281.52731293
31PLK31.52715557
32BRSK11.51282297
33MKNK21.50075970
34TESK21.48055749
35PIM21.38635453
36ZAK1.35703670
37MAP4K21.30542225
38MAP4K11.29306692
39DYRK31.28588280
40RPS6KA41.26504290
41RPS6KB21.26491055
42FRK1.25123071
43TGFBR11.23976165
44CHEK21.23427623
45GRK11.20342185
46STK101.18817937
47CDK81.18607382
48AURKA1.14475629
49PNCK1.13449903
50BCKDK1.11859205
51CDK41.11169712
52EIF2AK21.07553302
53MAP3K81.06590868
54OXSR11.05988492
55STK391.05476518
56CHEK11.03638348
57PLK21.03080464
58STK40.99934801
59INSRR0.97106144
60PIM10.95786096
61KDR0.94323359
62IRAK40.92422187
63WNK40.91230475
64ADRBK20.88375677
65PBK0.87016630
66PAK40.86387808
67NME10.85433757
68CLK10.84405425
69CSNK1G10.83537338
70TXK0.81945169
71CSNK1G30.81884538
72TEC0.80580360
73CSNK1G20.77654569
74CSNK2A10.76113131
75ATM0.75491956
76CDK120.75284189
77SCYL20.71231634
78CSNK2A20.70434817
79MST40.69143489
80CDK20.68941652
81BCR0.68808949
82LRRK20.67091112
83PDK20.66217416
84MAP3K40.66210172
85BTK0.64184754
86MAPK130.63395142
87ERBB30.63015105
88CSNK1A1L0.57418115
89NEK90.56851932
90TIE10.55986796
91BRAF0.55899085
92TESK10.55153377
93PRKCG0.55017169
94STK38L0.54696153
95RPS6KA50.54595072
96PAK10.53984138
97CDK10.53704613
98EPHA20.50539545
99FLT30.50320501
100ZAP700.50228800
101TYK20.50092058
102PINK10.49091660
103ILK0.48758913
104PRKCI0.48660164
105BLK0.48629698
106KIT0.47007507
107MELK0.47001960
108MAP2K30.42994096
109MUSK0.42864047
110CDK30.41975362
111IRAK30.41902420
112STK30.40582361
113NUAK10.40560633
114JAK30.38591555
115MAP2K70.38170605
116LYN0.38098774
117CDK60.37725345
118CSNK1E0.37679582
119CASK0.36983002
120FGFR20.36340404
121ABL20.34567491
122MAP3K120.34512770
123MAPKAPK50.34277352
124PRKDC0.33921443
125ALK0.32878162
126PRKCE0.32871974
127MAP3K110.32156135
128TAOK20.31842091
129CDK190.30895106
130CSF1R0.30777551
131BRD40.29651489
132FGFR10.28693418
133MINK10.27936984
134MARK30.27009922
135NLK0.26833811
136DYRK20.26585943
137DAPK10.26107755
138CSNK1A10.25997317
139STK240.25973855
140LIMK10.25869512
141IKBKB0.25705907
142SYK0.23971709
143RAF10.23130353
144YES10.21373918
145RPS6KA60.20970795

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.03895201
2Mismatch repair_Homo sapiens_hsa034304.18850478
3Ribosome_Homo sapiens_hsa030103.96675917
4Proteasome_Homo sapiens_hsa030503.82317779
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53906379
6RNA polymerase_Homo sapiens_hsa030203.47006485
7Spliceosome_Homo sapiens_hsa030403.28529481
8Base excision repair_Homo sapiens_hsa034103.21746316
9Homologous recombination_Homo sapiens_hsa034403.12388006
10Nucleotide excision repair_Homo sapiens_hsa034202.95304945
11RNA transport_Homo sapiens_hsa030132.85772874
12Pyrimidine metabolism_Homo sapiens_hsa002402.63530281
13Cell cycle_Homo sapiens_hsa041102.54981400
14Fanconi anemia pathway_Homo sapiens_hsa034602.29179006
15Non-homologous end-joining_Homo sapiens_hsa034502.26364942
16One carbon pool by folate_Homo sapiens_hsa006702.21877954
17Basal transcription factors_Homo sapiens_hsa030222.07220480
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96260043
19* RNA degradation_Homo sapiens_hsa030181.94642531
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74352456
21Propanoate metabolism_Homo sapiens_hsa006401.65717012
22mRNA surveillance pathway_Homo sapiens_hsa030151.54338093
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50934296
24p53 signaling pathway_Homo sapiens_hsa041151.46105108
25Purine metabolism_Homo sapiens_hsa002301.45284475
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45051975
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39134758
28Protein export_Homo sapiens_hsa030601.21444579
29Epstein-Barr virus infection_Homo sapiens_hsa051691.20623725
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20032310
31Cardiac muscle contraction_Homo sapiens_hsa042601.18153568
32Pyruvate metabolism_Homo sapiens_hsa006201.11622513
33Fatty acid elongation_Homo sapiens_hsa000621.07425907
34Steroid biosynthesis_Homo sapiens_hsa001001.01820040
35Antigen processing and presentation_Homo sapiens_hsa046121.01116961
36Primary immunodeficiency_Homo sapiens_hsa053401.00219704
37Herpes simplex infection_Homo sapiens_hsa051680.99500837
38Parkinsons disease_Homo sapiens_hsa050120.98337827
39Huntingtons disease_Homo sapiens_hsa050160.96495326
40Butanoate metabolism_Homo sapiens_hsa006500.93738073
41Systemic lupus erythematosus_Homo sapiens_hsa053220.92879756
42Phototransduction_Homo sapiens_hsa047440.91225083
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78112273
44Oocyte meiosis_Homo sapiens_hsa041140.77399294
45Oxidative phosphorylation_Homo sapiens_hsa001900.75996640
46Viral carcinogenesis_Homo sapiens_hsa052030.73303738
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71429086
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70425943
49Peroxisome_Homo sapiens_hsa041460.70332212
50Folate biosynthesis_Homo sapiens_hsa007900.70039526
51Pentose phosphate pathway_Homo sapiens_hsa000300.69133485
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68744214
53HTLV-I infection_Homo sapiens_hsa051660.66441917
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.64292850
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61267395
56Nitrogen metabolism_Homo sapiens_hsa009100.59185658
57Legionellosis_Homo sapiens_hsa051340.58428396
58Vitamin B6 metabolism_Homo sapiens_hsa007500.57523536
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56987268
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.56635593
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.54422995
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.53367214
63Measles_Homo sapiens_hsa051620.51353360
64Linoleic acid metabolism_Homo sapiens_hsa005910.50868915
65Sulfur relay system_Homo sapiens_hsa041220.50846635
66Glutathione metabolism_Homo sapiens_hsa004800.50690064
67Tryptophan metabolism_Homo sapiens_hsa003800.49479257
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48833417
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.48408945
70Thyroid cancer_Homo sapiens_hsa052160.48376922
71Caffeine metabolism_Homo sapiens_hsa002320.48340062
72N-Glycan biosynthesis_Homo sapiens_hsa005100.48138402
73Biosynthesis of amino acids_Homo sapiens_hsa012300.48112043
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46660558
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45603853
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43876217
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.43360013
78Basal cell carcinoma_Homo sapiens_hsa052170.43156239
79Hematopoietic cell lineage_Homo sapiens_hsa046400.43073314
80Fatty acid metabolism_Homo sapiens_hsa012120.43002993
81Apoptosis_Homo sapiens_hsa042100.42275187
82Sulfur metabolism_Homo sapiens_hsa009200.41515874
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39961422
84Fatty acid degradation_Homo sapiens_hsa000710.39569919
85Chemical carcinogenesis_Homo sapiens_hsa052040.39457467
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39428242
87Vitamin digestion and absorption_Homo sapiens_hsa049770.39200577
88Small cell lung cancer_Homo sapiens_hsa052220.38786072
89Shigellosis_Homo sapiens_hsa051310.38670535
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37629287
91Allograft rejection_Homo sapiens_hsa053300.37593026
92beta-Alanine metabolism_Homo sapiens_hsa004100.37530116
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37474460
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37386200
95Retinol metabolism_Homo sapiens_hsa008300.37287287
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36655252
97Hepatitis B_Homo sapiens_hsa051610.34788613
98Alzheimers disease_Homo sapiens_hsa050100.34751664
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34656082
100Hedgehog signaling pathway_Homo sapiens_hsa043400.34506522
101Selenocompound metabolism_Homo sapiens_hsa004500.34279461
102Arachidonic acid metabolism_Homo sapiens_hsa005900.33459026
103Ether lipid metabolism_Homo sapiens_hsa005650.33164647
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32625136
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31661057
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30243959
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30190378
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29893267
109Olfactory transduction_Homo sapiens_hsa047400.29345610
110Collecting duct acid secretion_Homo sapiens_hsa049660.28384385
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28173943
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27981811
113MicroRNAs in cancer_Homo sapiens_hsa052060.27755084
114Asthma_Homo sapiens_hsa053100.27619907
115Metabolic pathways_Homo sapiens_hsa011000.27596930
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27431252
117Influenza A_Homo sapiens_hsa051640.27419362
118Viral myocarditis_Homo sapiens_hsa054160.26961951
119Graft-versus-host disease_Homo sapiens_hsa053320.26251948
120Fructose and mannose metabolism_Homo sapiens_hsa000510.26068466
121Carbon metabolism_Homo sapiens_hsa012000.25461958
122Nicotine addiction_Homo sapiens_hsa050330.22206633
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21734440
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20902704
125Colorectal cancer_Homo sapiens_hsa052100.20872210
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20825733
127Galactose metabolism_Homo sapiens_hsa000520.20373095
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20172959
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19445882
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.18856748
131Autoimmune thyroid disease_Homo sapiens_hsa053200.17369248
132Alcoholism_Homo sapiens_hsa050340.17153289
133HIF-1 signaling pathway_Homo sapiens_hsa040660.16148309
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15988783
135Fat digestion and absorption_Homo sapiens_hsa049750.15484586
136TGF-beta signaling pathway_Homo sapiens_hsa043500.15321961
137Leishmaniasis_Homo sapiens_hsa051400.14644181
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.12688805
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12652687
140Acute myeloid leukemia_Homo sapiens_hsa052210.11574025
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10419232
142Pathways in cancer_Homo sapiens_hsa052000.09338497
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09161876
144Renin-angiotensin system_Homo sapiens_hsa046140.07445573
145Regulation of autophagy_Homo sapiens_hsa041400.06784467

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