EXOSC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.55945640
2DNA strand elongation (GO:0022616)4.47132693
3DNA replication checkpoint (GO:0000076)4.46652735
4telomere maintenance via semi-conservative replication (GO:0032201)4.45931309
5cullin deneddylation (GO:0010388)4.34882215
6DNA deamination (GO:0045006)4.27126791
7nuclear pore complex assembly (GO:0051292)4.25963451
8DNA replication initiation (GO:0006270)4.21997673
9protein deneddylation (GO:0000338)4.21336141
10telomere maintenance via recombination (GO:0000722)4.18989694
11CENP-A containing nucleosome assembly (GO:0034080)4.17767857
12DNA replication-dependent nucleosome organization (GO:0034723)4.05053688
13DNA replication-dependent nucleosome assembly (GO:0006335)4.05053688
14chromatin remodeling at centromere (GO:0031055)4.04798254
15ribosomal small subunit assembly (GO:0000028)3.98512477
16maturation of SSU-rRNA (GO:0030490)3.98426435
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.98019267
18sister chromatid segregation (GO:0000819)3.97448471
19formation of translation preinitiation complex (GO:0001731)3.96639039
20proteasome assembly (GO:0043248)3.96305484
21mitotic chromosome condensation (GO:0007076)3.95851380
22mitotic recombination (GO:0006312)3.95402228
23protein localization to chromosome, centromeric region (GO:0071459)3.93344666
24DNA unwinding involved in DNA replication (GO:0006268)3.90495784
25mitotic metaphase plate congression (GO:0007080)3.82352628
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.79214240
27mitotic sister chromatid cohesion (GO:0007064)3.79183542
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.77504363
29DNA ligation (GO:0006266)3.74784145
30ribosome biogenesis (GO:0042254)3.73596639
31negative regulation of DNA-dependent DNA replication (GO:2000104)3.72743826
32attachment of spindle microtubules to kinetochore (GO:0008608)3.71974606
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.71044916
34replication fork processing (GO:0031297)3.70166904
35DNA replication-independent nucleosome organization (GO:0034724)3.69877241
36DNA replication-independent nucleosome assembly (GO:0006336)3.69877241
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69867111
38spindle checkpoint (GO:0031577)3.69202977
39spliceosomal snRNP assembly (GO:0000387)3.66238126
40nucleobase biosynthetic process (GO:0046112)3.64945556
41telomere maintenance via telomere lengthening (GO:0010833)3.64821417
42kinetochore organization (GO:0051383)3.61169079
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.59518363
44negative regulation of ligase activity (GO:0051352)3.59518363
45purine nucleobase biosynthetic process (GO:0009113)3.58153954
46regulation of centriole replication (GO:0046599)3.57783440
47mitotic spindle checkpoint (GO:0071174)3.55925480
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.54439408
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.54439408
50negative regulation of chromosome segregation (GO:0051985)3.54241924
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.52466237
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.52109628
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.50076124
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.47659859
55non-recombinational repair (GO:0000726)3.47340916
56double-strand break repair via nonhomologous end joining (GO:0006303)3.47340916
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.47186590
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.47186590
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47175213
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47175213
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47175213
62histone exchange (GO:0043486)3.46139061
63viral mRNA export from host cell nucleus (GO:0046784)3.45849665
64kinetochore assembly (GO:0051382)3.45782878
65protein localization to kinetochore (GO:0034501)3.45625100
66establishment of integrated proviral latency (GO:0075713)3.45153973
67regulation of chromosome segregation (GO:0051983)3.43749037
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.43585166
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.43585166
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42104654
71regulation of DNA endoreduplication (GO:0032875)3.41161135
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.40241587
73termination of RNA polymerase III transcription (GO:0006386)3.40241587
74regulation of cellular amino acid metabolic process (GO:0006521)3.38489158
75rRNA modification (GO:0000154)3.38046790
76ribonucleoprotein complex biogenesis (GO:0022613)3.37540006
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.37477714
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37110601
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.37110601
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36622809
81regulation of mitotic spindle checkpoint (GO:1903504)3.36622809
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35867945
83metaphase plate congression (GO:0051310)3.35866623
84positive regulation of chromosome segregation (GO:0051984)3.35101511
85DNA double-strand break processing (GO:0000729)3.34987698
86regulation of sister chromatid segregation (GO:0033045)3.34526458
87regulation of mitotic sister chromatid separation (GO:0010965)3.34526458
88regulation of mitotic sister chromatid segregation (GO:0033047)3.34526458
89mitotic spindle assembly checkpoint (GO:0007094)3.30580965
90establishment of viral latency (GO:0019043)3.27346916
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27168017
92spindle assembly checkpoint (GO:0071173)3.25949821
93cell cycle G1/S phase transition (GO:0044843)3.25395410
94G1/S transition of mitotic cell cycle (GO:0000082)3.25395410
95regulation of double-strand break repair via homologous recombination (GO:0010569)3.25084094
967-methylguanosine mRNA capping (GO:0006370)3.24200918
97DNA topological change (GO:0006265)3.24034825
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23829209
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23829209
100transcription-coupled nucleotide-excision repair (GO:0006283)3.23268158
101chaperone-mediated protein transport (GO:0072321)3.21581526
102maturation of 5.8S rRNA (GO:0000460)3.21329682
103RNA capping (GO:0036260)3.21039818
1047-methylguanosine RNA capping (GO:0009452)3.21039818
105positive regulation of ligase activity (GO:0051351)3.19185285
106* rRNA processing (GO:0006364)3.18907116
107mitotic G2/M transition checkpoint (GO:0044818)3.18816734
108pore complex assembly (GO:0046931)3.18395299
109regulation of centrosome cycle (GO:0046605)3.16785922
110establishment of chromosome localization (GO:0051303)3.16457899
111IMP metabolic process (GO:0046040)3.16416011
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15844044
113nuclear pore organization (GO:0006999)3.15543661
114* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15244598
115pseudouridine synthesis (GO:0001522)3.15138332
116histone mRNA metabolic process (GO:0008334)3.12855975
117somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12648047
118somatic hypermutation of immunoglobulin genes (GO:0016446)3.12648047
119chromosome segregation (GO:0007059)3.11603564
120centriole replication (GO:0007099)3.11286045
121membrane disassembly (GO:0030397)3.10673399
122nuclear envelope disassembly (GO:0051081)3.10673399
123* rRNA metabolic process (GO:0016072)3.10226892
124* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09855522
125antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09690461
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09661341
127chromatin assembly or disassembly (GO:0006333)3.09492025
128mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09147023
129ribosomal large subunit biogenesis (GO:0042273)3.07603657
130DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.07533361
131ribosome assembly (GO:0042255)3.06111778
132histone H2A acetylation (GO:0043968)3.05604214
133spliceosomal complex assembly (GO:0000245)3.03435420
134regulation of mitochondrial translation (GO:0070129)3.02347963
135regulation of ubiquitin-protein transferase activity (GO:0051438)2.99628632
136mitotic sister chromatid segregation (GO:0000070)2.99133742
137mitotic nuclear envelope disassembly (GO:0007077)2.98062082
138IMP biosynthetic process (GO:0006188)2.97968892
139DNA catabolic process, exonucleolytic (GO:0000738)2.95330978
140telomere maintenance (GO:0000723)2.93025011
141telomere organization (GO:0032200)2.92306586
142rRNA methylation (GO:0031167)2.91823704
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.91385963
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91385963
145negative regulation of sister chromatid segregation (GO:0033046)2.91385963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.02360035
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27082951
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.22186429
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66040931
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.65248510
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.60176797
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49549265
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48912539
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.08685372
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04212343
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95849348
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91854943
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.90448520
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90424856
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86916510
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74707740
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.72321046
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66314585
19* VDR_23849224_ChIP-Seq_CD4+_Human2.59806581
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58736398
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45630954
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45388353
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42523107
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35145981
25FOXP3_21729870_ChIP-Seq_TREG_Human2.31575204
26XRN2_22483619_ChIP-Seq_HELA_Human2.22928318
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22795168
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18451928
29DCP1A_22483619_ChIP-Seq_HELA_Human2.16573816
30ELK1_19687146_ChIP-ChIP_HELA_Human2.08074135
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03875499
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03874501
33GABP_19822575_ChIP-Seq_HepG2_Human2.02877777
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.00696965
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00114010
36TTF2_22483619_ChIP-Seq_HELA_Human1.98675517
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95738320
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88766900
39* E2F1_21310950_ChIP-Seq_MCF-7_Human1.84683510
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83847228
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.82948674
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82095005
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80897321
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80338584
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78635450
46AR_21909140_ChIP-Seq_LNCAP_Human1.77814150
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73968117
48* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73538945
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72779945
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71469615
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58787501
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57369578
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47464606
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47030333
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46673600
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43823306
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42231245
58* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41476110
59CIITA_25753668_ChIP-Seq_RAJI_Human1.37916431
60EWS_26573619_Chip-Seq_HEK293_Human1.35897570
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31911785
62KDM5A_27292631_Chip-Seq_BREAST_Human1.31105912
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.30251777
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28911527
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26764307
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.21388805
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19601094
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17360777
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16153625
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15389252
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14969191
72MYC_18940864_ChIP-ChIP_HL60_Human1.14224060
73* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14114850
74FUS_26573619_Chip-Seq_HEK293_Human1.12899703
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08034544
76* SOX2_16153702_ChIP-ChIP_HESCs_Human1.07682569
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05890130
78* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04328036
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03647849
80TFEB_21752829_ChIP-Seq_HELA_Human1.02577532
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01615458
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.01246064
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01208842
84* SPI1_23547873_ChIP-Seq_NB4_Human0.98070024
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.97469501
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.95520164
87ZNF274_21170338_ChIP-Seq_K562_Hela0.94415450
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94050386
89EGR1_19374776_ChIP-ChIP_THP-1_Human0.91783614
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90649968
91VDR_22108803_ChIP-Seq_LS180_Human0.90608361
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89997314
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.88240199
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87651293
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85256109
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83968505
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80607062
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80330467
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78810579
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77913714
101IRF1_19129219_ChIP-ChIP_H3396_Human0.77279164
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.76491516
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75902153
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75325189
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73069134
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72902882
107* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72262315
108POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71553141
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69983487
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69803059
111* NANOG_16153702_ChIP-ChIP_HESCs_Human0.69549020
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69539417
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67340657
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.63454883
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.63454883
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.63454883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53738585
2MP0010094_abnormal_chromosome_stability4.58679044
3MP0008057_abnormal_DNA_replication4.27795650
4MP0003111_abnormal_nucleus_morphology4.22397017
5MP0004957_abnormal_blastocyst_morpholog4.18927475
6MP0008058_abnormal_DNA_repair3.97064520
7MP0003077_abnormal_cell_cycle3.76305292
8MP0008932_abnormal_embryonic_tissue3.08373850
9MP0008877_abnormal_DNA_methylation3.08198754
10MP0008007_abnormal_cellular_replicative2.97638871
11MP0003123_paternal_imprinting2.56157930
12MP0002396_abnormal_hematopoietic_system2.32675193
13MP0006292_abnormal_olfactory_placode2.15368290
14MP0003890_abnormal_embryonic-extraembry2.10150002
15MP0003786_premature_aging2.07248859
16MP0003121_genomic_imprinting1.91020555
17MP0001730_embryonic_growth_arrest1.83267309
18MP0009697_abnormal_copulation1.80325116
19MP0000350_abnormal_cell_proliferation1.75680974
20MP0003718_maternal_effect1.66398410
21MP0002102_abnormal_ear_morphology1.52865408
22MP0006072_abnormal_retinal_apoptosis1.50824437
23MP0000490_abnormal_crypts_of1.41252888
24MP0002160_abnormal_reproductive_system1.40057822
25MP0001529_abnormal_vocalization1.39693153
26MP0001835_abnormal_antigen_presentation1.38747652
27MP0000313_abnormal_cell_death1.36442553
28MP0009333_abnormal_splenocyte_physiolog1.34866882
29MP0010352_gastrointestinal_tract_polyps1.34282484
30MP0001293_anophthalmia1.32558619
31MP0001697_abnormal_embryo_size1.31342286
32MP0002210_abnormal_sex_determination1.28250824
33MP0008789_abnormal_olfactory_epithelium1.28128389
34MP0002080_prenatal_lethality1.27826924
35MP0003136_yellow_coat_color1.27631019
36MP0003937_abnormal_limbs/digits/tail_de1.27196293
37MP0003315_abnormal_perineum_morphology1.23988285
38MP0002019_abnormal_tumor_incidence1.23732955
39MP0005380_embryogenesis_phenotype1.23447739
40MP0001672_abnormal_embryogenesis/_devel1.23447739
41MP0002163_abnormal_gland_morphology1.22574494
42MP0001346_abnormal_lacrimal_gland1.19558879
43MP0006035_abnormal_mitochondrial_morpho1.19346940
44MP0004133_heterotaxia1.17885748
45MP0001286_abnormal_eye_development1.14859804
46MP0003787_abnormal_imprinting1.14633257
47MP0003186_abnormal_redox_activity1.13047378
48MP0002751_abnormal_autonomic_nervous1.11843564
49MP0002095_abnormal_skin_pigmentation1.11026929
50MP0005075_abnormal_melanosome_morpholog1.09597037
51MP0002233_abnormal_nose_morphology1.09433301
52MP0004808_abnormal_hematopoietic_stem1.09190368
53MP0010307_abnormal_tumor_latency1.08353636
54MP0003763_abnormal_thymus_physiology1.08312031
55MP0002398_abnormal_bone_marrow1.07991955
56MP0003984_embryonic_growth_retardation1.05942035
57MP0005389_reproductive_system_phenotype1.05035269
58MP0000015_abnormal_ear_pigmentation1.03414449
59MP0001145_abnormal_male_reproductive1.03068069
60MP0002697_abnormal_eye_size1.02853678
61MP0002085_abnormal_embryonic_tissue1.02795438
62MP0002088_abnormal_embryonic_growth/wei1.01707586
63MP0004147_increased_porphyrin_level1.01049695
64MP0000372_irregular_coat_pigmentation1.00928578
65MP0001188_hyperpigmentation0.99283547
66MP0000358_abnormal_cell_content/0.98845040
67MP0003806_abnormal_nucleotide_metabolis0.98629955
68MP0000689_abnormal_spleen_morphology0.98465077
69MP0002234_abnormal_pharynx_morphology0.96165331
70MP0002722_abnormal_immune_system0.96154397
71MP0002132_abnormal_respiratory_system0.95051808
72MP0001929_abnormal_gametogenesis0.93747408
73MP0002084_abnormal_developmental_patter0.93163549
74MP0008995_early_reproductive_senescence0.92511039
75MP0010030_abnormal_orbit_morphology0.92422396
76MP0005394_taste/olfaction_phenotype0.92415840
77MP0005499_abnormal_olfactory_system0.92415840
78MP0002111_abnormal_tail_morphology0.92398861
79MP0005174_abnormal_tail_pigmentation0.89639857
80MP0001853_heart_inflammation0.86779489
81MP0000653_abnormal_sex_gland0.86583728
82MP0008260_abnormal_autophagy0.85542136
83MP0000703_abnormal_thymus_morphology0.85522808
84MP0002938_white_spotting0.85339540
85MP0006036_abnormal_mitochondrial_physio0.84655091
86MP0002429_abnormal_blood_cell0.84597810
87MP0005397_hematopoietic_system_phenotyp0.84590134
88MP0001545_abnormal_hematopoietic_system0.84590134
89MP0003567_abnormal_fetal_cardiomyocyte0.84142307
90MP0005384_cellular_phenotype0.81897862
91MP0002086_abnormal_extraembryonic_tissu0.81116884
92MP0009785_altered_susceptibility_to0.80138371
93MP0001119_abnormal_female_reproductive0.79980620
94MP0006054_spinal_hemorrhage0.78718785
95MP0005391_vision/eye_phenotype0.77314818
96MP0005671_abnormal_response_to0.76658735
97MP0005253_abnormal_eye_physiology0.76585632
98MP0000716_abnormal_immune_system0.75842280
99MP0003698_abnormal_male_reproductive0.75305154
100MP0009703_decreased_birth_body0.74910828
101MP0005395_other_phenotype0.74431632
102MP0003119_abnormal_digestive_system0.73077869
103MP0004197_abnormal_fetal_growth/weight/0.72980784
104MP0009379_abnormal_foot_pigmentation0.72772571
105MP0000049_abnormal_middle_ear0.71290697
106MP0002420_abnormal_adaptive_immunity0.69935379
107MP0001905_abnormal_dopamine_level0.69490703
108MP0002452_abnormal_antigen_presenting0.69465737
109MP0001819_abnormal_immune_cell0.68815434
110MP0000428_abnormal_craniofacial_morphol0.68764189
111MP0002148_abnormal_hypersensitivity_rea0.68257815
112MP0005379_endocrine/exocrine_gland_phen0.67474836
113MP0003755_abnormal_palate_morphology0.67448810
114MP0000647_abnormal_sebaceous_gland0.65838863
115MP0003656_abnormal_erythrocyte_physiolo0.65676203
116MP0001986_abnormal_taste_sensitivity0.65203858
117MP0002092_abnormal_eye_morphology0.64952557
118MP0003699_abnormal_female_reproductive0.62348017
119MP0003941_abnormal_skin_development0.62178445
120MP0002161_abnormal_fertility/fecundity0.62120314
121MP0001764_abnormal_homeostasis0.61968162
122MP0009672_abnormal_birth_weight0.61865844
123MP0001299_abnormal_eye_distance/0.60982825
124MP0001800_abnormal_humoral_immune0.60541622
125MP0001324_abnormal_eye_pigmentation0.59798639
126MP0005621_abnormal_cell_physiology0.59563640
127MP0001919_abnormal_reproductive_system0.59321481
128MP0003861_abnormal_nervous_system0.58624979
129MP0000631_abnormal_neuroendocrine_gland0.54420561
130MP0003221_abnormal_cardiomyocyte_apopto0.54107547
131MP0001727_abnormal_embryo_implantation0.53423612
132MP0005408_hypopigmentation0.53284489
133MP0001984_abnormal_olfaction0.51815820

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.33005297
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.96601663
3Chromsome breakage (HP:0040012)4.81351424
4Aplastic anemia (HP:0001915)4.68731230
5Agnosia (HP:0010524)3.64176667
6Medulloblastoma (HP:0002885)3.61825933
7Abnormality of the preputium (HP:0100587)3.59235076
8Meckel diverticulum (HP:0002245)3.50605430
9Abnormality of chromosome stability (HP:0003220)3.47146315
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.36987616
11Abnormality of the ileum (HP:0001549)3.33346214
12Volvulus (HP:0002580)3.31669609
13Abnormality of the anterior horn cell (HP:0006802)3.24509590
14Degeneration of anterior horn cells (HP:0002398)3.24509590
15Rough bone trabeculation (HP:0100670)3.21101825
16Cerebral hypomyelination (HP:0006808)3.18793806
17Type I transferrin isoform profile (HP:0003642)3.11682120
18Breast hypoplasia (HP:0003187)3.11454301
19Acute encephalopathy (HP:0006846)2.92327705
20Abnormality of glycolysis (HP:0004366)2.91919880
21Increased serum pyruvate (HP:0003542)2.91919880
22Colon cancer (HP:0003003)2.91687774
23Abnormal lung lobation (HP:0002101)2.89206896
24Reticulocytopenia (HP:0001896)2.87700665
25Small intestinal stenosis (HP:0012848)2.85265844
26Duodenal stenosis (HP:0100867)2.85265844
27Myelodysplasia (HP:0002863)2.79136160
2811 pairs of ribs (HP:0000878)2.74419978
29Patellar aplasia (HP:0006443)2.69038520
30Nephroblastoma (Wilms tumor) (HP:0002667)2.62968841
31Supernumerary spleens (HP:0009799)2.62624614
32Bone marrow hypocellularity (HP:0005528)2.60151311
33Acute necrotizing encephalopathy (HP:0006965)2.58949957
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56925244
35Abnormal trabecular bone morphology (HP:0100671)2.56328580
363-Methylglutaconic aciduria (HP:0003535)2.56281243
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53795613
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53795613
39Oral leukoplakia (HP:0002745)2.51895692
40Type 2 muscle fiber atrophy (HP:0003554)2.49013342
41Embryonal renal neoplasm (HP:0011794)2.48905478
42Microvesicular hepatic steatosis (HP:0001414)2.48371998
43Aplasia/Hypoplasia of the patella (HP:0006498)2.46790243
44Ectopic kidney (HP:0000086)2.45407248
45Increased CSF lactate (HP:0002490)2.44255793
46Increased hepatocellular lipid droplets (HP:0006565)2.43830242
47Pancreatic fibrosis (HP:0100732)2.42492880
48Increased serum lactate (HP:0002151)2.40344935
49Asplenia (HP:0001746)2.38212530
50Sloping forehead (HP:0000340)2.36588896
51Abnormality of the duodenum (HP:0002246)2.36559080
52Microretrognathia (HP:0000308)2.35450085
53Muscle fiber atrophy (HP:0100295)2.35357111
54Abnormal mitochondria in muscle tissue (HP:0008316)2.34517072
55Mitochondrial inheritance (HP:0001427)2.34036264
56IgM deficiency (HP:0002850)2.29615728
57Absent thumb (HP:0009777)2.28740214
58Cerebral edema (HP:0002181)2.28714114
59Increased nuchal translucency (HP:0010880)2.27884435
60IgG deficiency (HP:0004315)2.27404305
61Pancytopenia (HP:0001876)2.27335288
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27319008
63Abnormal number of erythroid precursors (HP:0012131)2.25592117
64Triphalangeal thumb (HP:0001199)2.22656898
65Abnormality of cells of the erythroid lineage (HP:0012130)2.21388435
66Absent forearm bone (HP:0003953)2.19013083
67Aplasia involving forearm bones (HP:0009822)2.19013083
68Clubbing of toes (HP:0100760)2.15269897
69Aplasia/Hypoplasia of the spleen (HP:0010451)2.14984217
70Carpal bone hypoplasia (HP:0001498)2.13960661
71Hypoplasia of the pons (HP:0012110)2.11591012
72Poor head control (HP:0002421)2.10613415
73Abnormality of the pons (HP:0007361)2.09820625
74Premature graying of hair (HP:0002216)2.09734357
75Oligodactyly (hands) (HP:0001180)2.07460575
76Hepatic necrosis (HP:0002605)2.03049175
77Respiratory difficulties (HP:0002880)2.02875838
78Abnormal protein N-linked glycosylation (HP:0012347)2.02672470
79Abnormal protein glycosylation (HP:0012346)2.02672470
80Abnormal glycosylation (HP:0012345)2.02672470
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02672470
82Abnormality of the labia minora (HP:0012880)2.02055889
83Multiple enchondromatosis (HP:0005701)2.01809377
84Fibular aplasia (HP:0002990)1.99973284
85Lipid accumulation in hepatocytes (HP:0006561)1.98627123
86Abnormal spermatogenesis (HP:0008669)1.97877158
87Selective tooth agenesis (HP:0001592)1.97847354
88Hepatocellular necrosis (HP:0001404)1.97093204
89Pallor (HP:0000980)1.96744914
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95670012
91Hyperglycinemia (HP:0002154)1.95495200
92Neoplasm of the colon (HP:0100273)1.95416082
93Exertional dyspnea (HP:0002875)1.93162352
94Megaloblastic anemia (HP:0001889)1.92003705
95Irregular epiphyses (HP:0010582)1.91963661
96Rhabdomyosarcoma (HP:0002859)1.91365288
97Abnormality of the septum pellucidum (HP:0007375)1.91332348
98Fibular hypoplasia (HP:0003038)1.91310438
99Cleft eyelid (HP:0000625)1.91304102
100Macrocytic anemia (HP:0001972)1.90888263
101Duplicated collecting system (HP:0000081)1.90599811
102Lymphoma (HP:0002665)1.90332321
103Abnormal number of incisors (HP:0011064)1.89603845
104Facial cleft (HP:0002006)1.88866784
105Abnormality of methionine metabolism (HP:0010901)1.88201085
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.87660872
107Methylmalonic acidemia (HP:0002912)1.87374115
108Tracheoesophageal fistula (HP:0002575)1.87183338
109Horseshoe kidney (HP:0000085)1.87026393
110Impulsivity (HP:0100710)1.86928763
111Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86788955
112Renal Fanconi syndrome (HP:0001994)1.86746925
113Abnormality of the carotid arteries (HP:0005344)1.86375854
114Reduced antithrombin III activity (HP:0001976)1.85913151
115Exercise intolerance (HP:0003546)1.85894999
116Abnormality of serum amino acid levels (HP:0003112)1.85592583
117Absent epiphyses (HP:0010577)1.85344763
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85344763
119Progressive macrocephaly (HP:0004481)1.84777566
120Thrombocytosis (HP:0001894)1.84370905
121Septo-optic dysplasia (HP:0100842)1.83968305
122Absent radius (HP:0003974)1.82250924
123Short thumb (HP:0009778)1.80103317
124Abdominal situs inversus (HP:0003363)1.78909751
125Abnormality of abdominal situs (HP:0011620)1.78909751
126Leukodystrophy (HP:0002415)1.78467184
127Lactic acidosis (HP:0003128)1.78376718
128Glossoptosis (HP:0000162)1.78242288
129Pancreatic cysts (HP:0001737)1.77973119
130Absent septum pellucidum (HP:0001331)1.76197661
131Hyperalaninemia (HP:0003348)1.75738815
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75738815
133Abnormality of alanine metabolism (HP:0010916)1.75738815
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.75207623
135Cafe-au-lait spot (HP:0000957)1.74950147
136Choanal atresia (HP:0000453)1.70711192
137Abnormality of the renal collecting system (HP:0004742)1.70536343
138Short middle phalanx of the 5th finger (HP:0004220)1.70418987
139Arteriovenous malformation (HP:0100026)1.66876677
140Facial hemangioma (HP:0000329)1.65996065
141Rectovaginal fistula (HP:0000143)1.65224889
142Rectal fistula (HP:0100590)1.65224889
143Small hand (HP:0200055)1.64684160
144Hypoplastic pelvis (HP:0008839)1.64543690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.86573326
2STK163.69263579
3CDC73.67100934
4EIF2AK13.32606779
5WEE13.18812066
6PLK43.00485530
7SRPK12.85620095
8NEK12.82333057
9EIF2AK32.67622958
10ACVR1B2.51739892
11MKNK12.43112493
12VRK22.34557349
13TSSK62.30186059
14TRIM282.25579159
15VRK12.14693515
16NEK22.05921135
17NUAK11.87250210
18ZAK1.77518914
19TESK21.76813256
20PLK31.71298080
21TTK1.68881670
22TAF11.66793010
23ERBB31.65151947
24PLK11.63019378
25CCNB11.59323718
26BRSK21.55988184
27PBK1.52873355
28MKNK21.44525646
29ATR1.44444001
30BRSK11.41825977
31AURKB1.39639873
32PNCK1.38762212
33NME21.35179238
34TNIK1.32135357
35PIM21.21784196
36PASK1.21470598
37AURKA1.18198064
38WNK31.17359078
39CDK71.13041213
40CDK81.12869465
41EIF2AK21.09771254
42MAP3K121.08871641
43IRAK41.06414004
44TLK11.04347894
45DYRK31.02386623
46BRAF1.02179750
47CHEK21.00863886
48BRD40.95641764
49CDK190.95462848
50TESK10.94682734
51TGFBR10.93921169
52NME10.92502833
53LIMK10.92404606
54MST40.90324935
55CHEK10.89892555
56STK30.88651587
57PLK20.87932009
58CASK0.87646692
59AKT30.85668349
60DYRK20.81703007
61ALK0.79593213
62* CSNK2A10.79168251
63DAPK10.77651862
64ADRBK20.75204575
65RPS6KB20.73092345
66SCYL20.69108988
67RPS6KA40.69033989
68TEC0.68848890
69BMPR1B0.68010467
70ARAF0.67521327
71MAP4K20.67395311
72CSNK2A20.66567353
73TXK0.66465619
74ATM0.62495110
75STK40.62421470
76BMPR20.60876725
77CDK20.58021265
78PIM10.56801002
79YES10.56575208
80ERBB40.56218020
81CDK30.55093109
82PAK10.49614745
83CSNK1E0.48787041
84CDK10.47097455
85BCR0.45465660
86RPS6KA50.45360041
87PDK40.44875356
88PDK30.44875356
89CSF1R0.43460682
90PRKDC0.43280440
91KDR0.42896157
92BCKDK0.42625634
93MAP3K40.42544307
94PAK40.42015645
95MAP3K100.41948217
96CDK40.41088275
97MAP3K80.39769191
98EPHA20.39767225
99MYLK0.39700797
100PRKCI0.37788500
101BTK0.37541448
102IRAK30.35928854
103STK100.35770414
104STK240.35684009
105CDK90.34167300
106MAPK130.34072261
107TNK20.33780852
108LYN0.33657364
109CSNK1G10.32999516
110ZAP700.32772920
111FGFR10.32234103
112BLK0.31443106
113MELK0.31366322
114KIT0.30715953
115STK390.30512239
116OXSR10.30184106
117SYK0.30013942
118CSNK1G30.28267015
119STK38L0.27985167
120SIK30.26702153
121OBSCN0.24198164
122PDK20.23837091
123ILK0.23655628
124CLK10.23613943
125MARK30.21554288
126CDK60.20745766
127PRKACB0.18434467
128MAPK140.18364566
129CDK180.17994971
130CDK11A0.17408552
131WNK40.17024260
132CDK140.14498544
133CDK150.14413811

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.65673240
2Proteasome_Homo sapiens_hsa030504.65064185
3Mismatch repair_Homo sapiens_hsa034304.17914785
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54814195
5RNA polymerase_Homo sapiens_hsa030203.38417661
6Spliceosome_Homo sapiens_hsa030403.15516100
7Base excision repair_Homo sapiens_hsa034103.13266581
8Homologous recombination_Homo sapiens_hsa034403.01186110
9Ribosome_Homo sapiens_hsa030102.99112919
10RNA transport_Homo sapiens_hsa030132.87563106
11Nucleotide excision repair_Homo sapiens_hsa034202.78884391
12Pyrimidine metabolism_Homo sapiens_hsa002402.44219978
13Fanconi anemia pathway_Homo sapiens_hsa034602.42017535
14Cell cycle_Homo sapiens_hsa041102.34382108
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13773718
16Basal transcription factors_Homo sapiens_hsa030222.06490371
17* RNA degradation_Homo sapiens_hsa030182.01785477
18Non-homologous end-joining_Homo sapiens_hsa034501.95791798
19Protein export_Homo sapiens_hsa030601.91761007
20One carbon pool by folate_Homo sapiens_hsa006701.71769868
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51889224
22Purine metabolism_Homo sapiens_hsa002301.48902333
23mRNA surveillance pathway_Homo sapiens_hsa030151.39882766
24Oxidative phosphorylation_Homo sapiens_hsa001901.38234981
25Parkinsons disease_Homo sapiens_hsa050121.28781237
26p53 signaling pathway_Homo sapiens_hsa041151.26725282
27Huntingtons disease_Homo sapiens_hsa050161.18195691
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18071468
29Epstein-Barr virus infection_Homo sapiens_hsa051691.17245816
30Propanoate metabolism_Homo sapiens_hsa006401.09480282
31Selenocompound metabolism_Homo sapiens_hsa004501.06144632
32Pyruvate metabolism_Homo sapiens_hsa006201.03960523
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99307940
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98832079
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97798110
36Systemic lupus erythematosus_Homo sapiens_hsa053220.93820591
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91000252
38Antigen processing and presentation_Homo sapiens_hsa046120.90582158
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89699261
40Oocyte meiosis_Homo sapiens_hsa041140.83783657
41Primary immunodeficiency_Homo sapiens_hsa053400.79627427
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78203052
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76247496
44Steroid biosynthesis_Homo sapiens_hsa001000.74733749
45Herpes simplex infection_Homo sapiens_hsa051680.72181321
46Pentose phosphate pathway_Homo sapiens_hsa000300.69675963
47Folate biosynthesis_Homo sapiens_hsa007900.69150770
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68992586
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68052159
50Alzheimers disease_Homo sapiens_hsa050100.67578244
51Allograft rejection_Homo sapiens_hsa053300.64114959
52Viral carcinogenesis_Homo sapiens_hsa052030.63531338
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62218652
54Legionellosis_Homo sapiens_hsa051340.62167306
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.61477092
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61405239
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.55054925
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54315390
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53274830
60Fatty acid elongation_Homo sapiens_hsa000620.51688312
61N-Glycan biosynthesis_Homo sapiens_hsa005100.51373575
62Vitamin B6 metabolism_Homo sapiens_hsa007500.51278695
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51084583
64Asthma_Homo sapiens_hsa053100.48975774
65Type I diabetes mellitus_Homo sapiens_hsa049400.47183415
66Biosynthesis of amino acids_Homo sapiens_hsa012300.47042017
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45200552
68HTLV-I infection_Homo sapiens_hsa051660.44156308
69Alcoholism_Homo sapiens_hsa050340.41691226
70Autoimmune thyroid disease_Homo sapiens_hsa053200.41530610
71Basal cell carcinoma_Homo sapiens_hsa052170.41219526
72Arachidonic acid metabolism_Homo sapiens_hsa005900.40264867
73Cardiac muscle contraction_Homo sapiens_hsa042600.39066032
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.37779139
75Collecting duct acid secretion_Homo sapiens_hsa049660.37258393
76TGF-beta signaling pathway_Homo sapiens_hsa043500.36117200
77Measles_Homo sapiens_hsa051620.36051390
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35871883
79Graft-versus-host disease_Homo sapiens_hsa053320.35099816
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.34710119
81Fructose and mannose metabolism_Homo sapiens_hsa000510.33667060
82Glutathione metabolism_Homo sapiens_hsa004800.33546935
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33420368
84Metabolic pathways_Homo sapiens_hsa011000.33097401
85Regulation of autophagy_Homo sapiens_hsa041400.33062073
86Apoptosis_Homo sapiens_hsa042100.32794959
87Shigellosis_Homo sapiens_hsa051310.31374389
88Hedgehog signaling pathway_Homo sapiens_hsa043400.30741700
89Phagosome_Homo sapiens_hsa041450.28630743
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27458395
91Phototransduction_Homo sapiens_hsa047440.26954596
92Sulfur relay system_Homo sapiens_hsa041220.25420985
93Lysine degradation_Homo sapiens_hsa003100.24538411
94Vibrio cholerae infection_Homo sapiens_hsa051100.24374253
95Wnt signaling pathway_Homo sapiens_hsa043100.23391979
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23374839
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22261802
98Rheumatoid arthritis_Homo sapiens_hsa053230.22164423
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20752336
100Butanoate metabolism_Homo sapiens_hsa006500.20546226
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20465249
102Colorectal cancer_Homo sapiens_hsa052100.20088937
103Hippo signaling pathway_Homo sapiens_hsa043900.19344548
104Thyroid cancer_Homo sapiens_hsa052160.19337313
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18298193
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18105028
107Carbon metabolism_Homo sapiens_hsa012000.18037225
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17655697
109Sphingolipid metabolism_Homo sapiens_hsa006000.17294179
110Peroxisome_Homo sapiens_hsa041460.16631980
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16626777
112MicroRNAs in cancer_Homo sapiens_hsa052060.16576808
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16337149
114Hematopoietic cell lineage_Homo sapiens_hsa046400.15904987
115Hepatitis B_Homo sapiens_hsa051610.15421223
116Caffeine metabolism_Homo sapiens_hsa002320.14368474
117Influenza A_Homo sapiens_hsa051640.13942204
118Galactose metabolism_Homo sapiens_hsa000520.13655414
119Viral myocarditis_Homo sapiens_hsa054160.12482407
120Tryptophan metabolism_Homo sapiens_hsa003800.12296009
121Fatty acid metabolism_Homo sapiens_hsa012120.12271491
122Olfactory transduction_Homo sapiens_hsa047400.11640395
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11309880
124Renin-angiotensin system_Homo sapiens_hsa046140.11241062
125Leishmaniasis_Homo sapiens_hsa051400.09133593
126Pertussis_Homo sapiens_hsa051330.08630527
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07891366
128Arginine and proline metabolism_Homo sapiens_hsa003300.06874830
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.05723619
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.05481390
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05069897
132Sulfur metabolism_Homo sapiens_hsa009200.03087852
133Fatty acid degradation_Homo sapiens_hsa000710.02876838
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.00617663

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