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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.75739711
2axon extension involved in axon guidance (GO:0048846)5.81001315
3neuron projection extension involved in neuron projection guidance (GO:1902284)5.81001315
4collagen fibril organization (GO:0030199)4.68088235
5cell adhesion mediated by integrin (GO:0033627)4.33586175
6lung epithelium development (GO:0060428)4.15344387
7type B pancreatic cell proliferation (GO:0044342)4.09596623
8protein heterotrimerization (GO:0070208)4.02292543
9endodermal cell differentiation (GO:0035987)3.98025774
10wound healing, spreading of epidermal cells (GO:0035313)3.94865342
11negative regulation of chondrocyte differentiation (GO:0032331)3.86284975
12cell migration involved in heart development (GO:0060973)3.82577394
13mesenchymal-epithelial cell signaling (GO:0060638)3.80385707
14midgut development (GO:0007494)3.76137951
15hippo signaling (GO:0035329)3.70022518
16COPI coating of Golgi vesicle (GO:0048205)3.64540918
17Golgi transport vesicle coating (GO:0048200)3.64540918
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.61835910
19sequestering of extracellular ligand from receptor (GO:0035581)3.61488595
20lens fiber cell development (GO:0070307)3.61255239
21skin morphogenesis (GO:0043589)3.61028989
22mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.59008243
23paraxial mesoderm development (GO:0048339)3.57577605
24protein localization to endosome (GO:0036010)3.55899588
25mesodermal cell differentiation (GO:0048333)3.53468672
26epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.53275883
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.45379002
28bone trabecula formation (GO:0060346)3.42727179
29protein retention in ER lumen (GO:0006621)3.40020411
30positive regulation of epithelial to mesenchymal transition (GO:0010718)3.39553247
31negative regulation of fatty acid transport (GO:2000192)3.36732875
32embryonic camera-type eye development (GO:0031076)3.35257633
33atrioventricular valve morphogenesis (GO:0003181)3.33639892
34positive regulation of blood vessel endothelial cell migration (GO:0043536)3.31378809
35endocardial cushion morphogenesis (GO:0003203)3.29105678
36craniofacial suture morphogenesis (GO:0097094)3.27409034
37hypotonic response (GO:0006971)3.27200383
38wound healing, spreading of cells (GO:0044319)3.25324023
39adhesion of symbiont to host cell (GO:0044650)3.25301157
40virion attachment to host cell (GO:0019062)3.25301157
41extracellular matrix assembly (GO:0085029)3.19177930
42pericardium development (GO:0060039)3.18708030
43basement membrane organization (GO:0071711)3.17496374
44positive regulation of endothelial cell apoptotic process (GO:2000353)3.17402215
45regulation of plasminogen activation (GO:0010755)3.13642018
46positive regulation of osteoblast proliferation (GO:0033690)3.12205863
47planar cell polarity pathway involved in neural tube closure (GO:0090179)3.11917507
48mesenchyme morphogenesis (GO:0072132)3.10429395
49desmosome organization (GO:0002934)3.07138999
50epithelial cell fate commitment (GO:0072148)3.06423690
51adherens junction assembly (GO:0034333)3.06073700
52vascular endothelial growth factor signaling pathway (GO:0038084)3.05302749
53negative regulation of cartilage development (GO:0061037)3.05133994
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.05090283
55atrial septum morphogenesis (GO:0060413)3.04471114
56regulation of heart morphogenesis (GO:2000826)3.03179685
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01941753
58cell-substrate adherens junction assembly (GO:0007045)3.01431548
59focal adhesion assembly (GO:0048041)3.01431548
60cell migration involved in sprouting angiogenesis (GO:0002042)2.99368338
61collagen metabolic process (GO:0032963)2.99230453
62cellular response to vitamin D (GO:0071305)2.99121698
63positive regulation of extracellular matrix organization (GO:1903055)2.98984444
64endothelial cell morphogenesis (GO:0001886)2.98092200
65pattern specification involved in kidney development (GO:0061004)2.97791691
66regulation of hippo signaling (GO:0035330)2.97681852
67negative regulation of axon extension involved in axon guidance (GO:0048843)2.96688969
68endocardial cushion development (GO:0003197)2.95571781
69regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.95117094
70cellular response to vitamin (GO:0071295)2.94476945
71collecting duct development (GO:0072044)2.94475814
72extracellular fibril organization (GO:0043206)2.92616209
73heart valve formation (GO:0003188)2.92539249
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.92406038
75Notch signaling involved in heart development (GO:0061314)2.92082121
76renal system development (GO:0072001)2.91977270
77metanephric mesenchyme development (GO:0072075)2.91595209
78dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.91470305
79heart valve morphogenesis (GO:0003179)2.91050070
80radial glial cell differentiation (GO:0060019)2.89598999
81positive regulation of mesenchymal cell proliferation (GO:0002053)2.88998267
82adhesion of symbiont to host (GO:0044406)2.88784142
83epithelial cell-cell adhesion (GO:0090136)2.88496057
84collagen catabolic process (GO:0030574)2.87297920
85notochord development (GO:0030903)2.86228023
86blood vessel endothelial cell migration (GO:0043534)2.82825076
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.82657278
88multicellular organismal macromolecule metabolic process (GO:0044259)2.82145910
89substrate adhesion-dependent cell spreading (GO:0034446)2.81969935
90Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81125416
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.80658414
92stress fiber assembly (GO:0043149)2.79083886
93cardiac epithelial to mesenchymal transition (GO:0060317)2.78757614
94vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.78501532
95negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.78108564
96insulin-like growth factor receptor signaling pathway (GO:0048009)2.77229568
97embryonic foregut morphogenesis (GO:0048617)2.76406592
98actin filament depolymerization (GO:0030042)2.75704287
99branching involved in salivary gland morphogenesis (GO:0060445)2.75246067
100negative regulation of stem cell proliferation (GO:2000647)2.75110914
101plasma membrane repair (GO:0001778)2.74586190
102apoptotic cell clearance (GO:0043277)2.74376054
103glomerular basement membrane development (GO:0032836)2.74340628
104extracellular matrix organization (GO:0030198)2.73786334
105cartilage morphogenesis (GO:0060536)2.73376034
106chondrocyte development (GO:0002063)2.73351222
107regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.72960822
108cell surface receptor signaling pathway involved in heart development (GO:0061311)2.72730977
109extracellular structure organization (GO:0043062)2.72634346
110kidney mesenchyme development (GO:0072074)2.72578642
111barbed-end actin filament capping (GO:0051016)2.72485832
112extracellular matrix disassembly (GO:0022617)2.71765195
113positive regulation of BMP signaling pathway (GO:0030513)2.71229941
114protein localization to cell surface (GO:0034394)2.70772130
115regulation of establishment of planar polarity (GO:0090175)2.70530033
116muscle cell migration (GO:0014812)2.70130609
117multicellular organismal metabolic process (GO:0044236)2.69687797
118lymphangiogenesis (GO:0001946)2.69253179
119regulation of cartilage development (GO:0061035)2.68491882
120regulation of transforming growth factor beta1 production (GO:0032908)2.67511057
121regulation of transforming growth factor beta2 production (GO:0032909)2.66456074
122positive regulation of fatty acid beta-oxidation (GO:0032000)2.65936417
123hemidesmosome assembly (GO:0031581)2.65244659
124protein hydroxylation (GO:0018126)2.64896298
125fibril organization (GO:0097435)2.64638227
126substrate-dependent cell migration (GO:0006929)2.63720339
127positive regulation of astrocyte differentiation (GO:0048711)2.63468899
128negative regulation of osteoblast proliferation (GO:0033689)2.63439332
129regulation of mesenchymal cell proliferation (GO:0010464)2.62989955
130cell-substrate junction assembly (GO:0007044)2.62881719
131peptidyl-proline hydroxylation (GO:0019511)2.62879508
132smooth muscle tissue development (GO:0048745)2.62877191
133multicellular organismal catabolic process (GO:0044243)2.62856834
134negative regulation of smooth muscle cell migration (GO:0014912)2.62289570
135regulation of early endosome to late endosome transport (GO:2000641)2.61742415
136outer ear morphogenesis (GO:0042473)2.61166149
137coronary vasculature morphogenesis (GO:0060977)2.60825098
138embryonic viscerocranium morphogenesis (GO:0048703)2.60721777
139cranial suture morphogenesis (GO:0060363)2.60710689
140cochlea morphogenesis (GO:0090103)2.60633425
141COPII vesicle coating (GO:0048208)2.59382687
142negative regulation of anoikis (GO:2000811)2.58703403
143epoxygenase P450 pathway (GO:0019373)2.58452239
144positive regulation of cartilage development (GO:0061036)2.58343730
145positive regulation of stem cell differentiation (GO:2000738)2.57639403
146negative regulation of fibrinolysis (GO:0051918)2.57637957
147bone morphogenesis (GO:0060349)2.57321377
148retina vasculature morphogenesis in camera-type eye (GO:0061299)2.56523621
149venous blood vessel morphogenesis (GO:0048845)2.56074334
150respiratory tube development (GO:0030323)2.56066427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.14156905
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.70472645
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.73754357
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.34973570
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03072600
6CLOCK_20551151_ChIP-Seq_293T_Human2.85194896
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.28969090
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.25832769
9* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.24422322
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.23937100
11* CJUN_26792858_Chip-Seq_BT549_Human2.16441304
12CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.15433919
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11913968
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.11206834
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.10420368
16* BRD4_25478319_ChIP-Seq_HGPS_Human2.06892755
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06485976
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.03599587
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02576490
20* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.01728198
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.95747185
22* EP300_21415370_ChIP-Seq_HL-1_Mouse1.90683857
23* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.89875284
24* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.89875284
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81634897
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77423847
27* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72213613
28* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72213613
29AR_21909140_ChIP-Seq_LNCAP_Human1.69130465
30TP53_18474530_ChIP-ChIP_U2OS_Human1.69002613
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65902328
32* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65521693
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.64409440
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.62970189
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.61099247
36TP53_16413492_ChIP-PET_HCT116_Human1.60146485
37* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58521115
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55544623
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.54406534
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54010068
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.53936911
42* FOXO3_23340844_ChIP-Seq_DLD1_Human1.52703258
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51461121
44* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.47717912
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45512350
46UBF1/2_26484160_Chip-Seq_HMECs_Human1.45261312
47* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42614967
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42434765
49* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41608367
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.39454576
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.39331049
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37502802
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37345833
54* SOX2_20726797_ChIP-Seq_SW620_Human1.37212317
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35838651
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35160622
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35160622
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34572510
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31601212
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31191179
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.29047586
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.28216907
63* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28044402
64* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27330537
65* ATF3_27146783_Chip-Seq_COLON_Human1.25734741
66NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25655467
67* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20779561
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20342816
69* TP53_23651856_ChIP-Seq_MEFs_Mouse1.19269946
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18865217
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.17454501
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16552676
73* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15851722
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15488974
75* SA1_22415368_ChIP-Seq_MEFs_Mouse1.15151921
76* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14409339
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13517332
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13244587
79* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12650285
80ZNF263_19887448_ChIP-Seq_K562_Human1.12475964
81* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12042217
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11993097
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10826254
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10627342
85* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10100381
86P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09747991
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09146912
88* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08529939
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08209091
90* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07769944
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07343975
92* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06833089
93* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05335149
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.04817611
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04417157
96* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03840166
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02864657
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.02417507
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.02417507
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02193407
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00459654
102CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00344246
103RXR_22108803_ChIP-Seq_LS180_Human0.99437601
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99107114
105FOXM1_23109430_ChIP-Seq_U2OS_Human0.98702735
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98445997
107SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96648419
108RACK7_27058665_Chip-Seq_MCF-7_Human0.96440891
109KDM2B_26808549_Chip-Seq_K562_Human0.96384022
110* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96094496
111AHR_22903824_ChIP-Seq_MCF-7_Human0.95602782
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95340760
113TP53_22127205_ChIP-Seq_IMR90_Human0.94020754
114TCF4_18268006_ChIP-ChIP_LS174T_Human0.92558820
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92024824
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89186207
117* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88941792
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88399700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.05146094
2MP0003705_abnormal_hypodermis_morpholog4.26136231
3MP0005503_abnormal_tendon_morphology4.12604793
4MP0005275_abnormal_skin_tensile3.75894328
5MP0010030_abnormal_orbit_morphology3.74401731
6MP0001958_emphysema2.78941607
7MP0004272_abnormal_basement_membrane2.77462396
8MP0000566_synostosis2.74018399
9MP0003950_abnormal_plasma_membrane2.59196800
10MP0003279_aneurysm2.56337981
11MP0009053_abnormal_anal_canal2.55368980
12MP0005623_abnormal_meninges_morphology2.53163504
13MP0009780_abnormal_chondrocyte_physiolo2.23327161
14MP0010352_gastrointestinal_tract_polyps2.19315740
15MP0009384_cardiac_valve_regurgitation2.04358228
16MP0003566_abnormal_cell_adhesion2.00775290
17MP0005023_abnormal_wound_healing1.96388895
18* MP0005508_abnormal_skeleton_morphology1.92969575
19MP0003385_abnormal_body_wall1.91732489
20MP0003091_abnormal_cell_migration1.90997816
21MP0009250_abnormal_appendicular_skeleto1.87871139
22MP0003941_abnormal_skin_development1.86279004
23MP0001299_abnormal_eye_distance/1.81088632
24MP0002060_abnormal_skin_morphology1.80273034
25MP0000733_abnormal_muscle_development1.70589239
26MP0006054_spinal_hemorrhage1.70197765
27MP0002249_abnormal_larynx_morphology1.67811243
28MP0000537_abnormal_urethra_morphology1.61806110
29MP0010368_abnormal_lymphatic_system1.59233961
30MP0002282_abnormal_trachea_morphology1.56975027
31MP0005076_abnormal_cell_differentiation1.51089469
32MP0002295_abnormal_pulmonary_circulatio1.49455754
33MP0000013_abnormal_adipose_tissue1.48579324
34MP0003115_abnormal_respiratory_system1.47713050
35MP0002896_abnormal_bone_mineralization1.44818078
36MP0003937_abnormal_limbs/digits/tail_de1.40356820
37MP0005248_abnormal_Harderian_gland1.36746367
38* MP0003755_abnormal_palate_morphology1.34078642
39MP0004858_abnormal_nervous_system1.32858153
40MP0000767_abnormal_smooth_muscle1.32280973
41MP0003942_abnormal_urinary_system1.30919656
42* MP0000428_abnormal_craniofacial_morphol1.29723015
43* MP0000163_abnormal_cartilage_morphology1.28659030
44MP0000049_abnormal_middle_ear1.28266422
45MP0001849_ear_inflammation1.27499284
46MP0002932_abnormal_joint_morphology1.26122140
47MP0003283_abnormal_digestive_organ1.23992108
48MP0000751_myopathy1.22265682
49MP0002108_abnormal_muscle_morphology1.20945589
50MP0002168_other_aberrant_phenotype1.20673261
51MP0000762_abnormal_tongue_morphology1.20039257
52* MP0002115_abnormal_skeleton_extremities1.17567497
53MP0003252_abnormal_bile_duct1.14700980
54MP0005595_abnormal_vascular_smooth1.12118229
55MP0005409_darkened_coat_color1.11716865
56MP0002089_abnormal_postnatal_growth/wei1.11164144
57MP0001243_abnormal_dermal_layer1.10921939
58MP0001348_abnormal_lacrimal_gland1.10060715
59MP0009840_abnormal_foam_cell1.09265695
60MP0002877_abnormal_melanocyte_morpholog1.06985022
61MP0000432_abnormal_head_morphology1.06876423
62MP0004134_abnormal_chest_morphology1.06866668
63MP0003191_abnormal_cellular_cholesterol1.06659116
64* MP0005390_skeleton_phenotype1.06199938
65MP0003935_abnormal_craniofacial_develop1.05746503
66MP0003453_abnormal_keratinocyte_physiol1.04845125
67MP0000534_abnormal_ureter_morphology1.03635858
68* MP0002113_abnormal_skeleton_development1.03161634
69MP0000569_abnormal_digit_pigmentation1.02621227
70MP0003300_gastrointestinal_ulcer0.99811287
71MP0000516_abnormal_urinary_system0.98787009
72MP0005367_renal/urinary_system_phenotyp0.98787009
73MP0002233_abnormal_nose_morphology0.98665430
74MP0010234_abnormal_vibrissa_follicle0.97586861
75MP0002697_abnormal_eye_size0.94815291
76MP0002116_abnormal_craniofacial_bone0.93052270
77MP0002111_abnormal_tail_morphology0.92035861
78MP0000750_abnormal_muscle_regeneration0.91518895
79MP0000467_abnormal_esophagus_morphology0.90983626
80MP0003045_fibrosis0.86842689
81MP0001915_intracranial_hemorrhage0.85602823
82* MP0002109_abnormal_limb_morphology0.84856110
83MP0000462_abnormal_digestive_system0.84741902
84* MP0005257_abnormal_intraocular_pressure0.84268660
85MP0002128_abnormal_blood_circulation0.84037986
86MP0003448_altered_tumor_morphology0.82480462
87MP0002925_abnormal_cardiovascular_devel0.82323158
88MP0001879_abnormal_lymphatic_vessel0.82288233
89MP0001614_abnormal_blood_vessel0.81843879
90MP0002998_abnormal_bone_remodeling0.81753541
91MP0000003_abnormal_adipose_tissue0.81427062
92* MP0002092_abnormal_eye_morphology0.80503521
93MP0002234_abnormal_pharynx_morphology0.80390063
94MP0001542_abnormal_bone_strength0.79532058
95MP0004185_abnormal_adipocyte_glucose0.79066280
96MP0003828_pulmonary_edema0.77011772
97MP0004233_abnormal_muscle_weight0.76243516
98MP0001293_anophthalmia0.75434632
99MP0000759_abnormal_skeletal_muscle0.74300013
100MP0000579_abnormal_nail_morphology0.74208311
101MP0005187_abnormal_penis_morphology0.72548024
102MP0001533_abnormal_skeleton_physiology0.72397515
103* MP0005197_abnormal_uvea_morphology0.72187954
104MP0000647_abnormal_sebaceous_gland0.72082429
105MP0005360_urolithiasis0.71604404
106MP0001346_abnormal_lacrimal_gland0.71413190
107MP0002933_joint_inflammation0.69632243
108MP0005501_abnormal_skin_physiology0.69475874
109MP0002177_abnormal_outer_ear0.66942395
110MP0005220_abnormal_exocrine_pancreas0.66446811
111* MP0005193_abnormal_anterior_eye0.66111293
112MP0004197_abnormal_fetal_growth/weight/0.64957691
113MP0005375_adipose_tissue_phenotype0.64822925
114MP0001175_abnormal_lung_morphology0.64228989
115MP0000858_altered_metastatic_potential0.64196378
116MP0000749_muscle_degeneration0.63779602
117MP0001216_abnormal_epidermal_layer0.63423822
118MP0005164_abnormal_response_to0.63244737
119MP0005395_other_phenotype0.63126395
120MP0010386_abnormal_urinary_bladder0.62952955
121MP0005165_increased_susceptibility_to0.62391006
122MP0010771_integument_phenotype0.61536094
123MP0002796_impaired_skin_barrier0.61498105
124MP0005621_abnormal_cell_physiology0.61374242
125MP0006138_congestive_heart_failure0.59217201
126MP0003868_abnormal_feces_composition0.58378943

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.00023181
2Premature rupture of membranes (HP:0001788)6.53824653
3Neonatal short-limb short stature (HP:0008921)4.88094750
4Shallow orbits (HP:0000586)4.64164346
5Aortic dissection (HP:0002647)4.08642062
6Atrophic scars (HP:0001075)3.91012393
7Peritonitis (HP:0002586)3.86528093
8Coronal craniosynostosis (HP:0004440)3.75648748
9Aortic aneurysm (HP:0004942)3.47510349
10Soft skin (HP:0000977)3.42203004
11Ankle contracture (HP:0006466)3.41016272
12Fragile skin (HP:0001030)3.30262214
13Mitral valve prolapse (HP:0001634)3.22322528
14Cerebral aneurysm (HP:0004944)3.22192283
15Infantile muscular hypotonia (HP:0008947)3.09494429
16Broad metatarsal (HP:0001783)3.09407717
17Dilatation of the ascending aorta (HP:0005111)3.08202925
18Abnormality of dentin (HP:0010299)2.89484055
19Genu recurvatum (HP:0002816)2.86977038
20Aplasia involving bones of the upper limbs (HP:0009823)2.84083880
21Aplasia of the phalanges of the hand (HP:0009802)2.84083880
22Aplasia involving bones of the extremities (HP:0009825)2.84083880
23Bladder diverticulum (HP:0000015)2.81415716
24Cervical subluxation (HP:0003308)2.80296337
25Camptodactyly of toe (HP:0001836)2.72083549
26Vascular tortuosity (HP:0004948)2.71398829
27Blue sclerae (HP:0000592)2.68166625
28Hyperextensible skin (HP:0000974)2.62105150
29Short nail (HP:0001799)2.61741100
30Deviation of the hallux (HP:0010051)2.61308966
31Vertebral compression fractures (HP:0002953)2.57856928
32Arterial tortuosity (HP:0005116)2.57809891
33Slender build (HP:0001533)2.54564010
34Hallux valgus (HP:0001822)2.51332913
35Aortic regurgitation (HP:0001659)2.49306434
36Wrist flexion contracture (HP:0001239)2.49240702
37Increased connective tissue (HP:0009025)2.48280378
38Wormian bones (HP:0002645)2.46880032
39Biconcave vertebral bodies (HP:0004586)2.45713817
40Spinal rigidity (HP:0003306)2.44540389
41Mitral stenosis (HP:0001718)2.42378167
42Abnormality of carpal bone ossification (HP:0006257)2.37583343
43Overgrowth (HP:0001548)2.32587562
44Abnormal ossification of hand bones (HP:0005921)2.29316552
45Cardiovascular calcification (HP:0011915)2.29012967
46Wide anterior fontanel (HP:0000260)2.21559864
47Abnormal delivery (HP:0001787)2.20995740
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.20692803
49Osteolytic defects of the hand bones (HP:0009699)2.20692803
50Tarsal synostosis (HP:0008368)2.19689061
51Joint contractures involving the joints of the feet (HP:0100492)2.19154047
52Flexion contracture of toe (HP:0005830)2.19154047
53Turricephaly (HP:0000262)2.17017748
54Bronchomalacia (HP:0002780)2.16138177
55Increased variability in muscle fiber diameter (HP:0003557)2.15280490
56Disproportionate tall stature (HP:0001519)2.13487949
57Tibial bowing (HP:0002982)2.13174523
58* Aneurysm (HP:0002617)2.08217410
59Striae distensae (HP:0001065)2.08174347
60Short 4th metacarpal (HP:0010044)2.07885913
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07885913
62Absent frontal sinuses (HP:0002688)2.07338975
63Hypoventilation (HP:0002791)2.05936914
64Elbow flexion contracture (HP:0002987)2.05026411
65Follicular hyperkeratosis (HP:0007502)2.00415007
66Synostosis involving bones of the lower limbs (HP:0009138)1.99816732
67Synostosis involving bones of the feet (HP:0009140)1.99816732
68Partial duplication of the phalanx of hand (HP:0009999)1.99374170
69Abnormality of the middle phalanges of the toes (HP:0010183)1.99102337
70Type 1 muscle fiber predominance (HP:0003803)1.98885713
71Ectopia lentis (HP:0001083)1.96729654
72Increased density of long bones (HP:0006392)1.96724737
73Spondylolisthesis (HP:0003302)1.94256225
74Bowed forearm bones (HP:0003956)1.94170656
75Bowing of the arm (HP:0006488)1.94170656
76Buphthalmos (HP:0000557)1.93826803
77Thin bony cortex (HP:0002753)1.93617585
78Aortic valve stenosis (HP:0001650)1.93512626
79Broad hallux (HP:0010055)1.93451330
80Broad face (HP:0000283)1.92427650
81Subacute progressive viral hepatitis (HP:0006572)1.91708714
82Achilles tendon contracture (HP:0001771)1.91251118
83Broad toe (HP:0001837)1.89656325
84Cupped ribs (HP:0000887)1.88339100
85Abnormal hand bone ossification (HP:0010660)1.88162098
86Joint laxity (HP:0001388)1.86540884
87Abnormality of the 4th metacarpal (HP:0010012)1.86069723
88Delayed cranial suture closure (HP:0000270)1.84716708
89Ulnar bowing (HP:0003031)1.84518550
90Thoracolumbar scoliosis (HP:0002944)1.84331077
91Distal upper limb amyotrophy (HP:0007149)1.84225657
92Upper limb amyotrophy (HP:0009129)1.84225657
93Abnormality of the acetabulum (HP:0003170)1.83686645
94Right ventricular cardiomyopathy (HP:0011663)1.83222120
95Bowel diverticulosis (HP:0005222)1.83092695
96Natal tooth (HP:0000695)1.83028808
97Deep venous thrombosis (HP:0002625)1.82608664
98* Osteoarthritis (HP:0002758)1.81866248
99Abnormality of skeletal muscle fiber size (HP:0012084)1.81056100
100Inguinal hernia (HP:0000023)1.80811751
101Fused cervical vertebrae (HP:0002949)1.79840351
102Mitral regurgitation (HP:0001653)1.78821837
103Aplasia cutis congenita (HP:0001057)1.78625964
104Myocardial infarction (HP:0001658)1.78071555
105Synostosis of carpal bones (HP:0005048)1.77806181
106Abnormality of the phalanges of the hallux (HP:0010057)1.77736823
107Spinal cord lesions (HP:0100561)1.77566667
108Syringomyelia (HP:0003396)1.77566667
109Protruding ear (HP:0000411)1.76308178
110Femoral bowing (HP:0002980)1.76237286
111Preaxial foot polydactyly (HP:0001841)1.76229023
112Venous abnormality (HP:0002624)1.75775478
113Limited elbow extension (HP:0001377)1.75051874
114Lymphangioma (HP:0100764)1.74775416
115Renal duplication (HP:0000075)1.74773796
116Neonatal death (HP:0003811)1.73571361
117Mildly elevated creatine phosphokinase (HP:0008180)1.72697497
118Abnormality of the Achilles tendon (HP:0005109)1.72300682
119Knee flexion contracture (HP:0006380)1.72090735
120Abnormality of the distal phalanges of the toes (HP:0010182)1.71930799
121Abnormality of the peritoneum (HP:0002585)1.71826638
122Hyperacusis (HP:0010780)1.71710878
123Generalized amyotrophy (HP:0003700)1.71380967
124Broad ribs (HP:0000885)1.70854199
125Long toe (HP:0010511)1.69343031
126Congenital glaucoma (HP:0001087)1.68978458
127Round ear (HP:0100830)1.68700299
128Distal lower limb amyotrophy (HP:0008944)1.68378823
129Mesomelia (HP:0003027)1.67780761
130Joint stiffness (HP:0001387)1.67279643
131Leiomyosarcoma (HP:0100243)1.67151000
132Uterine leiomyosarcoma (HP:0002891)1.67151000
133Ovoid vertebral bodies (HP:0003300)1.67071589
134Flat acetabular roof (HP:0003180)1.66157615
135Radial bowing (HP:0002986)1.65202016
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63713704
137Abnormality of the distal phalanx of the thumb (HP:0009617)1.63336161
138Arachnodactyly (HP:0001166)1.63074562
139Reduced subcutaneous adipose tissue (HP:0003758)1.62028702
140Abnormality of skull ossification (HP:0002703)1.61912513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.38524167
2MYLK3.60579882
3TRIB33.60384736
4DDR23.55958726
5TTN3.47687021
6EPHB23.18683575
7PDGFRA3.05315175
8LATS22.88518338
9PKN22.75624995
10NTRK12.48949673
11AKT32.21153235
12SIK12.18748227
13FGFR32.17209818
14FER2.15716132
15ICK2.11220593
16FGFR12.08630470
17EPHA32.00991737
18STK38L1.93392704
19BMX1.90332496
20FRK1.85918717
21EPHA21.82672289
22ERN11.82323962
23PTK61.80778854
24PTK21.72784232
25RIPK11.71010326
26MOS1.68745883
27STK31.68706076
28IRAK31.61954448
29NEK91.57000566
30PAK21.54002844
31DMPK1.50005277
32PAK31.47039461
33PAK41.46114853
34BUB11.41379549
35MET1.36841546
36NUAK11.29892384
37FLT31.24463692
38MTOR1.23633200
39MAP3K101.22722669
40ROCK11.22169414
41ERBB41.21918892
42MELK1.21681561
43CDK81.20928663
44PDGFRB1.19678356
45CDC42BPA1.16874670
46LRRK21.10464059
47KSR11.10168823
48PTK2B1.09625004
49RPS6KA41.08486551
50CDK61.04741509
51ILK1.04520372
52PLK21.03930348
53ROCK20.99159345
54MAP3K60.98966101
55MST1R0.97532761
56PIK3CA0.96227694
57TRPM70.92830895
58PRKG20.92772855
59LMTK20.91023878
60RPS6KA20.80564309
61FGFR20.78905105
62ARAF0.78215413
63TAOK20.76300702
64ABL20.76204209
65ERBB20.75585139
66CDK120.75057742
67SMG10.74604301
68CDK90.74543619
69PIK3CG0.73772726
70TGFBR20.72668078
71CAMK1D0.72273396
72MAP3K70.72144159
73MAP2K10.69027932
74GRK70.67680829
75DAPK30.67622037
76FGFR40.65466059
77ERBB30.65430316
78ADRBK10.63961001
79INSR0.63019444
80MAP3K30.62543489
81TLK10.62049021
82PRPF4B0.60820724
83PNCK0.57260377
84KSR20.56947124
85MAP2K30.56784665
86TGFBR10.55047269
87CHUK0.54305695
88NEK10.51414240
89STK100.48309628
90WNK10.46920427
91JAK10.46809811
92PAK60.45858100
93MAPK70.42680736
94GSK3A0.42200806
95RET0.41464778
96AKT20.41289185
97IGF1R0.41155592
98ZAK0.40967651
99MAP3K120.39882732
100SRC0.38429406
101PIM20.36635948
102CLK10.36222504
103MAP3K20.35918295
104CAMK1G0.34142513
105TAOK10.33334382
106PRKCZ0.33001993
107RPS6KC10.32826160
108RPS6KL10.32826160
109TTK0.32102008
110DYRK1B0.32001218
111MAP3K80.31575100
112CAMK2G0.31398898
113CDK70.31070696
114STK380.29063015
115MAPKAPK20.28932222
116BRAF0.28583250
117EEF2K0.27053446
118BRSK20.26899408
119EGFR0.26545979
120PRKD10.26508935
121EPHB10.26211777
122MAPK90.26123398
123MAPK10.25989804
124BRSK10.25674533
125PAK10.25343274
126MAPK110.24349218
127NEK20.23800588
128ABL10.23744759
129LIMK10.23478276
130PBK0.22883903
131TESK10.22514054
132PRKCE0.21381228
133SCYL20.20886892
134PRKD20.18927680

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.49142875
2Focal adhesion_Homo sapiens_hsa045102.65297729
3Bladder cancer_Homo sapiens_hsa052192.62352552
4Basal cell carcinoma_Homo sapiens_hsa052172.55160845
5Proteoglycans in cancer_Homo sapiens_hsa052052.48779322
6Adherens junction_Homo sapiens_hsa045202.41080119
7TGF-beta signaling pathway_Homo sapiens_hsa043502.28807588
8Hippo signaling pathway_Homo sapiens_hsa043902.19689492
9MicroRNAs in cancer_Homo sapiens_hsa052062.10172073
10Hedgehog signaling pathway_Homo sapiens_hsa043402.08678770
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.05417350
12Small cell lung cancer_Homo sapiens_hsa052221.95780372
13Amoebiasis_Homo sapiens_hsa051461.92985206
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.80378570
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.79645877
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72386626
17Dilated cardiomyopathy_Homo sapiens_hsa054141.64691687
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.57318533
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54995946
20Melanoma_Homo sapiens_hsa052181.54445991
21Chronic myeloid leukemia_Homo sapiens_hsa052201.53910943
22Malaria_Homo sapiens_hsa051441.50881809
23Notch signaling pathway_Homo sapiens_hsa043301.48575114
24Complement and coagulation cascades_Homo sapiens_hsa046101.46005876
25Protein digestion and absorption_Homo sapiens_hsa049741.40414969
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.30339515
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25264598
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24628271
29* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22315293
30Glioma_Homo sapiens_hsa052141.21552396
31Wnt signaling pathway_Homo sapiens_hsa043101.20781993
32Axon guidance_Homo sapiens_hsa043601.20238659
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.19861214
34Pancreatic cancer_Homo sapiens_hsa052121.18398854
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.17223483
36Prostate cancer_Homo sapiens_hsa052151.17152048
37TNF signaling pathway_Homo sapiens_hsa046681.13842301
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12559474
39Tight junction_Homo sapiens_hsa045301.08556728
40Pathways in cancer_Homo sapiens_hsa052001.07325349
41Arginine biosynthesis_Homo sapiens_hsa002201.06983385
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05688534
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02218959
44Melanogenesis_Homo sapiens_hsa049161.00862601
45N-Glycan biosynthesis_Homo sapiens_hsa005100.97964259
46Dorso-ventral axis formation_Homo sapiens_hsa043200.97185512
47Rap1 signaling pathway_Homo sapiens_hsa040150.97146977
48HTLV-I infection_Homo sapiens_hsa051660.96168827
49Viral myocarditis_Homo sapiens_hsa054160.95025670
50Lysine degradation_Homo sapiens_hsa003100.94098361
51Other glycan degradation_Homo sapiens_hsa005110.93877006
52Prion diseases_Homo sapiens_hsa050200.93723549
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92593351
54PPAR signaling pathway_Homo sapiens_hsa033200.92215264
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.90980301
56Galactose metabolism_Homo sapiens_hsa000520.89604520
57Endometrial cancer_Homo sapiens_hsa052130.87927139
58Sulfur metabolism_Homo sapiens_hsa009200.84002528
59Renal cell carcinoma_Homo sapiens_hsa052110.83939422
60Nitrogen metabolism_Homo sapiens_hsa009100.83119899
61p53 signaling pathway_Homo sapiens_hsa041150.82969350
62Ovarian steroidogenesis_Homo sapiens_hsa049130.81910341
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78700557
64Caffeine metabolism_Homo sapiens_hsa002320.77718130
65Colorectal cancer_Homo sapiens_hsa052100.75558013
66Toxoplasmosis_Homo sapiens_hsa051450.74924000
67Endocytosis_Homo sapiens_hsa041440.74129658
68mTOR signaling pathway_Homo sapiens_hsa041500.72467586
69Sphingolipid metabolism_Homo sapiens_hsa006000.71494683
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68290219
71Insulin resistance_Homo sapiens_hsa049310.68147094
72HIF-1 signaling pathway_Homo sapiens_hsa040660.67464033
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66942217
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.65864908
75Shigellosis_Homo sapiens_hsa051310.65461534
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.65142869
77Vibrio cholerae infection_Homo sapiens_hsa051100.64818265
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63978279
79Hepatitis B_Homo sapiens_hsa051610.63640738
80FoxO signaling pathway_Homo sapiens_hsa040680.63266353
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60479930
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59625782
83Ras signaling pathway_Homo sapiens_hsa040140.58761552
84Apoptosis_Homo sapiens_hsa042100.57674933
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57456732
86Pertussis_Homo sapiens_hsa051330.55246194
87GnRH signaling pathway_Homo sapiens_hsa049120.55228190
88Phagosome_Homo sapiens_hsa041450.54864084
89Bile secretion_Homo sapiens_hsa049760.54744645
90Platelet activation_Homo sapiens_hsa046110.54346617
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.53774251
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53598846
93Tryptophan metabolism_Homo sapiens_hsa003800.53533701
94Fatty acid degradation_Homo sapiens_hsa000710.53284156
95AMPK signaling pathway_Homo sapiens_hsa041520.52909001
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52854740
97Non-small cell lung cancer_Homo sapiens_hsa052230.52307567
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52112385
99Gap junction_Homo sapiens_hsa045400.51832056
100Estrogen signaling pathway_Homo sapiens_hsa049150.51563695
101Thyroid hormone synthesis_Homo sapiens_hsa049180.50933719
102Renin-angiotensin system_Homo sapiens_hsa046140.50904245
103Viral carcinogenesis_Homo sapiens_hsa052030.49562387
104ErbB signaling pathway_Homo sapiens_hsa040120.49057246
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.47803287
106Chemical carcinogenesis_Homo sapiens_hsa052040.47521460
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45770870
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44079784
109Staphylococcus aureus infection_Homo sapiens_hsa051500.43817816
110Hepatitis C_Homo sapiens_hsa051600.43569977
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43150674
112Thyroid cancer_Homo sapiens_hsa052160.42188713
113Salmonella infection_Homo sapiens_hsa051320.41958001
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41423680
115Prolactin signaling pathway_Homo sapiens_hsa049170.40069649
116Leishmaniasis_Homo sapiens_hsa051400.39504226
117VEGF signaling pathway_Homo sapiens_hsa043700.39010574
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.36300961
119Lysosome_Homo sapiens_hsa041420.35760526
120Fatty acid metabolism_Homo sapiens_hsa012120.35610988
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34800296
122Insulin signaling pathway_Homo sapiens_hsa049100.34662587
123MAPK signaling pathway_Homo sapiens_hsa040100.33001587
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.30857461

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