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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.63792008
2COPI coating of Golgi vesicle (GO:0048205)5.06056258
3Golgi transport vesicle coating (GO:0048200)5.06056258
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.37776415
5protein retention in ER lumen (GO:0006621)4.36973120
6protein heterotrimerization (GO:0070208)4.32597928
7basement membrane organization (GO:0071711)4.29705999
8collagen fibril organization (GO:0030199)4.27519744
9chondrocyte proliferation (GO:0035988)4.04063414
10apoptotic cell clearance (GO:0043277)4.00116957
11desmosome organization (GO:0002934)3.95584194
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.92391778
13protein localization to endosome (GO:0036010)3.86991063
14dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.83847303
15epithelial cell-cell adhesion (GO:0090136)3.82419272
16endodermal cell differentiation (GO:0035987)3.74444065
17skin morphogenesis (GO:0043589)3.65667223
18type B pancreatic cell proliferation (GO:0044342)3.50430431
19regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.48875985
20substrate-dependent cell migration (GO:0006929)3.46930584
21negative regulation of fatty acid transport (GO:2000192)3.46316145
22peptidyl-proline hydroxylation (GO:0019511)3.44873330
23cell adhesion mediated by integrin (GO:0033627)3.41734436
24vascular endothelial growth factor signaling pathway (GO:0038084)3.41302645
25mesodermal cell differentiation (GO:0048333)3.36431602
26activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.32735026
27protein hydroxylation (GO:0018126)3.27147040
28positive regulation of endothelial cell apoptotic process (GO:2000353)3.26309867
29barbed-end actin filament capping (GO:0051016)3.24585504
30positive regulation of nuclease activity (GO:0032075)3.23109546
31cell migration involved in heart development (GO:0060973)3.20238008
32retina vasculature morphogenesis in camera-type eye (GO:0061299)3.16400513
33hypotonic response (GO:0006971)3.10511128
34positive regulation of histone deacetylation (GO:0031065)3.07343225
35focal adhesion assembly (GO:0048041)3.05518756
36cell-substrate adherens junction assembly (GO:0007045)3.05518756
37regulation of fatty acid beta-oxidation (GO:0031998)3.05057127
38vesicle coating (GO:0006901)3.04336764
39endocardial cushion development (GO:0003197)3.02837374
40cellular response to vitamin (GO:0071295)3.01079017
41hyaluronan catabolic process (GO:0030214)2.99629685
42wound healing, spreading of cells (GO:0044319)2.99326437
43negative regulation of cell size (GO:0045792)2.98564467
44positive regulation of blood vessel endothelial cell migration (GO:0043536)2.97777999
45axon extension involved in axon guidance (GO:0048846)2.96861922
46neuron projection extension involved in neuron projection guidance (GO:1902284)2.96861922
47collagen metabolic process (GO:0032963)2.94821545
48sequestering of extracellular ligand from receptor (GO:0035581)2.94184338
49membrane protein ectodomain proteolysis (GO:0006509)2.93880352
50substrate adhesion-dependent cell spreading (GO:0034446)2.93862014
514-hydroxyproline metabolic process (GO:0019471)2.93395257
52regulation of transforming growth factor beta2 production (GO:0032909)2.93100953
53COPII vesicle coating (GO:0048208)2.91868579
54extracellular fibril organization (GO:0043206)2.89001526
55polarized epithelial cell differentiation (GO:0030859)2.88882986
56negative regulation of keratinocyte proliferation (GO:0010839)2.88521389
57positive regulation of osteoblast proliferation (GO:0033690)2.86329131
58regulation of nuclease activity (GO:0032069)2.85904366
59endoplasmic reticulum unfolded protein response (GO:0030968)2.85492995
60positive regulation of epithelial to mesenchymal transition (GO:0010718)2.85383572
61glomerular basement membrane development (GO:0032836)2.84570737
62negative regulation of erythrocyte differentiation (GO:0045647)2.84347193
63extracellular matrix disassembly (GO:0022617)2.83900578
64keratan sulfate catabolic process (GO:0042340)2.81609481
65cellular response to vitamin D (GO:0071305)2.81284542
66negative regulation of cartilage development (GO:0061037)2.80716253
67extracellular matrix organization (GO:0030198)2.80298733
68protein maturation by protein folding (GO:0022417)2.80055827
69cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.79865241
70extracellular structure organization (GO:0043062)2.79202796
71stress fiber assembly (GO:0043149)2.78448981
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.78255701
73paraxial mesoderm development (GO:0048339)2.78229445
74collagen catabolic process (GO:0030574)2.78038441
75extracellular matrix assembly (GO:0085029)2.76371438
76endothelial cell morphogenesis (GO:0001886)2.76200702
77multicellular organismal macromolecule metabolic process (GO:0044259)2.75553079
78renal filtration (GO:0097205)2.75436510
79muscle cell migration (GO:0014812)2.73258668
80venous blood vessel morphogenesis (GO:0048845)2.72521634
81virion attachment to host cell (GO:0019062)2.71764961
82adhesion of symbiont to host cell (GO:0044650)2.71764961
83cellular response to unfolded protein (GO:0034620)2.70484843
84regulation of tight junction assembly (GO:2000810)2.69975210
85positive regulation of natural killer cell differentiation (GO:0032825)2.69865283
86regulation of translational fidelity (GO:0006450)2.68985817
87fibril organization (GO:0097435)2.68975400
88bone trabecula formation (GO:0060346)2.68896421
89positive regulation of extracellular matrix organization (GO:1903055)2.68775314
90cell migration involved in sprouting angiogenesis (GO:0002042)2.65870177
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65036068
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.65036068
93epithelial cell differentiation involved in prostate gland development (GO:0060742)2.64714835
94negative regulation of smooth muscle cell migration (GO:0014912)2.64511610
95negative regulation of anoikis (GO:2000811)2.64065645
96adhesion of symbiont to host (GO:0044406)2.64038292
97blood vessel maturation (GO:0001955)2.63905077
98regulation of cholesterol homeostasis (GO:2000188)2.63420152
99cell-substrate junction assembly (GO:0007044)2.62471807
100pentose-phosphate shunt (GO:0006098)2.62384045
101cellular copper ion homeostasis (GO:0006878)2.62193672
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.62150898
103multicellular organismal metabolic process (GO:0044236)2.61263069
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60421544
105anatomical structure regression (GO:0060033)2.60404986
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59086698
107multicellular organismal catabolic process (GO:0044243)2.58752880
108glial cell migration (GO:0008347)2.58708245
109ER-nucleus signaling pathway (GO:0006984)2.58658641
110blood vessel endothelial cell migration (GO:0043534)2.58630961
111tricarboxylic acid metabolic process (GO:0072350)2.58225173
112vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.57106879
113regulation of plasminogen activation (GO:0010755)2.56791467
114bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55906909
115* heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.55738039
116morphogenesis of an endothelium (GO:0003159)2.55601867
117endothelial tube morphogenesis (GO:0061154)2.55601867
118regulation of transforming growth factor beta1 production (GO:0032908)2.55098416
119antigen processing and presentation via MHC class Ib (GO:0002475)2.54722843
120regulation of SMAD protein import into nucleus (GO:0060390)2.54319836
121pinocytosis (GO:0006907)2.53768636
122positive regulation of glycogen biosynthetic process (GO:0045725)2.53213663
123semaphorin-plexin signaling pathway (GO:0071526)2.52859549
124germ cell migration (GO:0008354)2.52446534
125maternal placenta development (GO:0001893)2.52401671
126proline biosynthetic process (GO:0006561)2.52150425
127cellular response to topologically incorrect protein (GO:0035967)2.51348133
128regulation of establishment of planar polarity (GO:0090175)2.51147663
129cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.50856166
130mesenchymal-epithelial cell signaling (GO:0060638)2.50297432
131positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.49344660
132protein localization to cell surface (GO:0034394)2.48086711
133hippo signaling (GO:0035329)2.48009854
134glomerular filtration (GO:0003094)2.47542229
135branching involved in mammary gland duct morphogenesis (GO:0060444)2.46497067
136positive regulation of protein deacetylation (GO:0090312)2.46328310
137regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43900520
138positive regulation of triglyceride biosynthetic process (GO:0010867)2.42810529
139negative regulation of lipid transport (GO:0032369)2.42114862
140adherens junction assembly (GO:0034333)2.41981388
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41410078
142branching involved in salivary gland morphogenesis (GO:0060445)2.41311171
143cellular response to nutrient (GO:0031670)2.40985502
144positive regulation of collagen biosynthetic process (GO:0032967)2.39107049
145negative regulation of chondrocyte differentiation (GO:0032331)2.38612019
146plasma membrane repair (GO:0001778)2.38488438
147negative regulation of fibrinolysis (GO:0051918)2.38338409
148wound healing, spreading of epidermal cells (GO:0035313)2.37058042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.93416390
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.75540853
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.47569378
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.46971227
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.22802741
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.22551821
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.09963257
8CLOCK_20551151_ChIP-Seq_293T_Human2.98989548
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67811567
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41038415
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.40675209
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.26943432
13MYC_22102868_ChIP-Seq_BL_Human2.25106262
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.20350529
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.04595434
16VDR_21846776_ChIP-Seq_THP-1_Human2.03212447
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96755822
18LXR_22292898_ChIP-Seq_THP-1_Human1.95684880
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.90760084
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85385067
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.84370354
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81922092
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81550473
24ZNF263_19887448_ChIP-Seq_K562_Human1.80530456
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74249824
26RACK7_27058665_Chip-Seq_MCF-7_Human1.73389916
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71589402
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70977915
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68591761
30* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67544131
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67231038
32ATF3_27146783_Chip-Seq_COLON_Human1.66653543
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.65901764
34CJUN_26792858_Chip-Seq_BT549_Human1.65516536
35TCF7_22412390_ChIP-Seq_EML_Mouse1.62745383
36KDM2B_26808549_Chip-Seq_DND41_Human1.56941530
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52831429
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.51917017
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51498376
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.50770247
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50123891
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46825768
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43083816
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40238440
45EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.39342792
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.39027709
47FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.38866265
48* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37591967
49* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35894095
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35430983
51JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34613318
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32847425
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32334396
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31694355
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31112875
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28309367
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27824094
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.25753046
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25482666
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25309982
61SOX2_20726797_ChIP-Seq_SW620_Human1.25151756
62MAF_26560356_Chip-Seq_TH1_Human1.24842688
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.24270584
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24195639
65TP53_22127205_ChIP-Seq_IMR90_Human1.24162920
66AR_21909140_ChIP-Seq_LNCAP_Human1.23883929
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22590584
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.20958415
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.20913771
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.20913771
71BRD4_25478319_ChIP-Seq_HGPS_Human1.20634536
72VDR_24763502_ChIP-Seq_THP-1_Human1.19071342
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18223503
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17985670
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17836724
76UTX_26944678_Chip-Seq_JUKART_Human1.17765561
77* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17649958
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17374277
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16662785
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16415694
81TP53_18474530_ChIP-ChIP_U2OS_Human1.16063489
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15490947
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15127679
84NCOR1_26117541_ChIP-Seq_K562_Human1.13843207
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13511022
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12645419
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12637156
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12297025
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11123086
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10113071
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08124208
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07620985
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07529275
94FOXM1_23109430_ChIP-Seq_U2OS_Human1.07336346
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06882468
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06735345
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06385792
98* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04203107
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04062649
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03364164
101E2F7_22180533_ChIP-Seq_HELA_Human1.03052227
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.03026234
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02974905
104* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02652813
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02186672
106* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00921778
107* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00921778
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00328666
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.00304086
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00029871
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99514063
112* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99417217
113KDM2B_26808549_Chip-Seq_K562_Human0.99324584
114* KDM2B_26808549_Chip-Seq_JURKAT_Human0.98919143
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98497397
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98413608
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98045106
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96785311
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96099126
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95464204
121SCL_19346495_ChIP-Seq_HPC-7_Human0.93312591
122SA1_22415368_ChIP-Seq_MEFs_Mouse0.93214867
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92926563
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92926563
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.92363644
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91307014
127MYC_18555785_ChIP-Seq_MESCs_Mouse0.90987996
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90259141
129* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89193568
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.88391835
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87899661
132MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87891296
133* TET1_21490601_ChIP-Seq_MESCs_Mouse0.85784576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.50675446
2MP0003705_abnormal_hypodermis_morpholog4.40890211
3MP0005503_abnormal_tendon_morphology3.41174366
4MP0005275_abnormal_skin_tensile3.25025721
5MP0003279_aneurysm3.11770323
6MP0006054_spinal_hemorrhage2.81838088
7MP0004272_abnormal_basement_membrane2.79538711
8MP0009384_cardiac_valve_regurgitation2.51309703
9MP0010368_abnormal_lymphatic_system2.45210661
10MP0010352_gastrointestinal_tract_polyps2.44440490
11MP0001958_emphysema2.40442275
12MP0003941_abnormal_skin_development2.37912374
13MP0003566_abnormal_cell_adhesion2.19904042
14MP0003283_abnormal_digestive_organ2.16909202
15MP0000579_abnormal_nail_morphology1.99938463
16MP0003300_gastrointestinal_ulcer1.98805234
17MP0005023_abnormal_wound_healing1.94450180
18MP0005623_abnormal_meninges_morphology1.81783190
19MP0000762_abnormal_tongue_morphology1.79629788
20MP0010234_abnormal_vibrissa_follicle1.79547871
21MP0010030_abnormal_orbit_morphology1.78723762
22MP0003950_abnormal_plasma_membrane1.73788694
23MP0004858_abnormal_nervous_system1.59783005
24MP0002877_abnormal_melanocyte_morpholog1.44141050
25MP0000733_abnormal_muscle_development1.43869070
26* MP0005508_abnormal_skeleton_morphology1.42648946
27MP0009278_abnormal_bone_marrow1.40688674
28MP0002060_abnormal_skin_morphology1.37804382
29MP0005409_darkened_coat_color1.37116590
30MP0000467_abnormal_esophagus_morphology1.35490904
31MP0000767_abnormal_smooth_muscle1.34578756
32MP0002896_abnormal_bone_mineralization1.33773286
33MP0003091_abnormal_cell_migration1.33231587
34MP0003453_abnormal_keratinocyte_physiol1.32080148
35MP0000013_abnormal_adipose_tissue1.30900076
36MP0005076_abnormal_cell_differentiation1.26732111
37MP0009840_abnormal_foam_cell1.24239075
38MP0004084_abnormal_cardiac_muscle1.22598316
39MP0001216_abnormal_epidermal_layer1.19794380
40MP0001879_abnormal_lymphatic_vessel1.19303704
41MP0002796_impaired_skin_barrier1.19114290
42MP0009780_abnormal_chondrocyte_physiolo1.17611295
43MP0004808_abnormal_hematopoietic_stem1.16749020
44MP0005257_abnormal_intraocular_pressure1.16195887
45MP0001243_abnormal_dermal_layer1.15518620
46MP0002089_abnormal_postnatal_growth/wei1.14084930
47MP0001849_ear_inflammation1.10663306
48MP0005501_abnormal_skin_physiology1.07362483
49MP0002396_abnormal_hematopoietic_system1.06920124
50MP0008260_abnormal_autophagy1.06550553
51MP0005058_abnormal_lysosome_morphology1.05273845
52MP0009053_abnormal_anal_canal1.05256664
53MP0002295_abnormal_pulmonary_circulatio1.05091966
54MP0000537_abnormal_urethra_morphology1.04933911
55MP0005197_abnormal_uvea_morphology1.04708186
56MP0003115_abnormal_respiratory_system1.03224998
57MP0003329_amyloid_beta_deposits1.01902189
58MP0002282_abnormal_trachea_morphology0.99989875
59MP0001915_intracranial_hemorrhage0.99598602
60MP0002933_joint_inflammation0.98284581
61MP0000462_abnormal_digestive_system0.98238204
62MP0002932_abnormal_joint_morphology0.98200928
63MP0002128_abnormal_blood_circulation0.98119621
64MP0003942_abnormal_urinary_system0.97981833
65MP0002108_abnormal_muscle_morphology0.95985263
66MP0000750_abnormal_muscle_regeneration0.95749007
67MP0000428_abnormal_craniofacial_morphol0.95483086
68MP0000534_abnormal_ureter_morphology0.95146001
69MP0005220_abnormal_exocrine_pancreas0.95114822
70MP0003045_fibrosis0.93712447
71* MP0005390_skeleton_phenotype0.93080597
72MP0004233_abnormal_muscle_weight0.92653802
73* MP0000163_abnormal_cartilage_morphology0.91330981
74MP0002098_abnormal_vibrissa_morphology0.90070892
75MP0010771_integument_phenotype0.89453298
76MP0000003_abnormal_adipose_tissue0.88976491
77MP0001614_abnormal_blood_vessel0.87609496
78MP0002168_other_aberrant_phenotype0.87148553
79MP0002166_altered_tumor_susceptibility0.87146640
80MP0003385_abnormal_body_wall0.86317886
81MP0003448_altered_tumor_morphology0.86059224
82MP0000858_altered_metastatic_potential0.85825812
83MP0004185_abnormal_adipocyte_glucose0.85094868
84MP0004197_abnormal_fetal_growth/weight/0.84313179
85MP0005165_increased_susceptibility_to0.83897506
86MP0001533_abnormal_skeleton_physiology0.83872990
87MP0010630_abnormal_cardiac_muscle0.83515482
88MP0000751_myopathy0.82533468
89MP0005360_urolithiasis0.82448121
90* MP0002113_abnormal_skeleton_development0.82369462
91MP0002115_abnormal_skeleton_extremities0.82269399
92MP0009250_abnormal_appendicular_skeleto0.81841593
93MP0000678_abnormal_parathyroid_gland0.81357784
94MP0004087_abnormal_muscle_fiber0.79943660
95MP0005397_hematopoietic_system_phenotyp0.79289282
96MP0001545_abnormal_hematopoietic_system0.79289282
97MP0008775_abnormal_heart_ventricle0.79195374
98MP0002269_muscular_atrophy0.78743083
99MP0005375_adipose_tissue_phenotype0.78610362
100MP0005666_abnormal_adipose_tissue0.78493729
101MP0000432_abnormal_head_morphology0.78350401
102MP0000627_abnormal_mammary_gland0.77849519
103MP0002925_abnormal_cardiovascular_devel0.77789675
104MP0005621_abnormal_cell_physiology0.77372445
105MP0005193_abnormal_anterior_eye0.77300254
106MP0001661_extended_life_span0.75936650
107MP0004782_abnormal_surfactant_physiolog0.75646865
108MP0000343_altered_response_to0.74827631
109MP0005164_abnormal_response_to0.73882879
110MP0004130_abnormal_muscle_cell0.73116448
111MP0004264_abnormal_extraembryonic_tissu0.73100874
112MP0003755_abnormal_palate_morphology0.72799831
113MP0002697_abnormal_eye_size0.72009288
114MP0001299_abnormal_eye_distance/0.71909703
115MP0003252_abnormal_bile_duct0.70816730
116* MP0003795_abnormal_bone_structure0.70134519
117MP0002998_abnormal_bone_remodeling0.70027640
118MP0001542_abnormal_bone_strength0.69984223
119MP0003315_abnormal_perineum_morphology0.69681666
120MP0003567_abnormal_fetal_cardiomyocyte0.68971154
121MP0005451_abnormal_body_composition0.68624942
122MP0003191_abnormal_cellular_cholesterol0.68334533
123MP0002086_abnormal_extraembryonic_tissu0.67499410
124MP0000377_abnormal_hair_follicle0.67356746
125MP0000266_abnormal_heart_morphology0.67285029
126MP0010678_abnormal_skin_adnexa0.67112338
127MP0010307_abnormal_tumor_latency0.67100292
128MP0002139_abnormal_hepatobiliary_system0.66117437
129MP0005595_abnormal_vascular_smooth0.65654469
130MP0006138_congestive_heart_failure0.65235307
131MP0000759_abnormal_skeletal_muscle0.65107729
132MP0009931_abnormal_skin_appearance0.64764144
133MP0003935_abnormal_craniofacial_develop0.64519272
134MP0000249_abnormal_blood_vessel0.64291630
135MP0001175_abnormal_lung_morphology0.64186743
136MP0005670_abnormal_white_adipose0.63494411
137MP0002135_abnormal_kidney_morphology0.63289785
138MP0000747_muscle_weakness0.61651467
139MP0002234_abnormal_pharynx_morphology0.60582926
140MP0000477_abnormal_intestine_morphology0.60357713
141MP0000598_abnormal_liver_morphology0.60235708

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.20497148
2Premature rupture of membranes (HP:0001788)5.60054967
3Cerebral aneurysm (HP:0004944)4.31490999
4Ankle contracture (HP:0006466)4.23153127
5Shallow orbits (HP:0000586)4.02041416
6Aortic dissection (HP:0002647)3.94663441
7Aortic aneurysm (HP:0004942)3.94312720
8Broad metatarsal (HP:0001783)3.88693296
9Cervical subluxation (HP:0003308)3.83271853
10Peritonitis (HP:0002586)3.56809593
11Vertebral compression fractures (HP:0002953)3.39816599
12Bladder diverticulum (HP:0000015)3.34445274
13Atrophic scars (HP:0001075)3.24775526
14Dilatation of the ascending aorta (HP:0005111)3.21468802
15Soft skin (HP:0000977)3.20515034
16Biconcave vertebral bodies (HP:0004586)3.08152540
17Short nail (HP:0001799)3.02733185
18Blue sclerae (HP:0000592)3.01930155
19Fragile skin (HP:0001030)2.87834763
20Mitral valve prolapse (HP:0001634)2.85912455
21* Aneurysm (HP:0002617)2.81849322
22Wormian bones (HP:0002645)2.76367351
23Milia (HP:0001056)2.73715125
24Genu recurvatum (HP:0002816)2.72482532
25Natal tooth (HP:0000695)2.68259143
26Thin bony cortex (HP:0002753)2.65409624
27Fragile nails (HP:0001808)2.64755501
28Bowel diverticulosis (HP:0005222)2.60113353
29Vascular tortuosity (HP:0004948)2.57573142
30Type 1 muscle fiber predominance (HP:0003803)2.56356381
31Abnormality of the acetabulum (HP:0003170)2.55898960
32Hand muscle atrophy (HP:0009130)2.54887297
33Distal upper limb amyotrophy (HP:0007149)2.53281220
34Upper limb amyotrophy (HP:0009129)2.53281220
35Increased connective tissue (HP:0009025)2.47989532
36Onycholysis (HP:0001806)2.42796406
37Lymphangioma (HP:0100764)2.42764507
38Spinal rigidity (HP:0003306)2.41324373
39Arterial tortuosity (HP:0005116)2.40434064
40Neonatal short-limb short stature (HP:0008921)2.39558269
41Spondylolisthesis (HP:0003302)2.36960224
42Ectopia lentis (HP:0001083)2.28986606
43Nonimmune hydrops fetalis (HP:0001790)2.26026571
44Abnormality of dentin (HP:0010299)2.25367958
45Mitral stenosis (HP:0001718)2.23567620
46Wrist flexion contracture (HP:0001239)2.21081671
47Hyperextensible skin (HP:0000974)2.19624949
48Radial bowing (HP:0002986)2.17416501
49Pterygium (HP:0001059)2.14736094
50Elbow flexion contracture (HP:0002987)2.11699673
51Flat acetabular roof (HP:0003180)2.11367958
52Abnormality of the distal phalanges of the toes (HP:0010182)2.09656268
53Striae distensae (HP:0001065)2.08601124
54Alopecia of scalp (HP:0002293)2.07242159
55Short 4th metacarpal (HP:0010044)2.06789809
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06789809
57Abnormal delivery (HP:0001787)2.05837529
58Abnormality of the peritoneum (HP:0002585)2.05701472
59Deviation of the hallux (HP:0010051)2.04003783
60Thick nail (HP:0001805)2.03392286
61Breech presentation (HP:0001623)2.02443602
62Increased density of long bones (HP:0006392)2.02220207
63Joint stiffness (HP:0001387)2.01836524
64Ankyloglossia (HP:0010296)1.99496576
65Advanced eruption of teeth (HP:0006288)1.98432457
66Cardiovascular calcification (HP:0011915)1.98412740
67Selective tooth agenesis (HP:0001592)1.98005792
68Abnormality of carpal bone ossification (HP:0006257)1.97826287
69Abnormality of oral frenula (HP:0000190)1.96703578
70Back pain (HP:0003418)1.96345299
71Mildly elevated creatine phosphokinase (HP:0008180)1.95168565
72Hallux valgus (HP:0001822)1.94721484
73Joint laxity (HP:0001388)1.94205894
74Increased variability in muscle fiber diameter (HP:0003557)1.93644699
75Mesangial abnormality (HP:0001966)1.92170348
76Beaking of vertebral bodies (HP:0004568)1.91204982
77Bowed forearm bones (HP:0003956)1.91109277
78Bowing of the arm (HP:0006488)1.91109277
79Platyspondyly (HP:0000926)1.90018569
80Broad face (HP:0000283)1.89107575
81Osteolytic defects of the phalanges of the hand (HP:0009771)1.88747926
82Osteolytic defects of the hand bones (HP:0009699)1.88747926
83Plantar hyperkeratosis (HP:0007556)1.88700798
84Enlarged penis (HP:0000040)1.88333082
85Osteopenia (HP:0000938)1.87720890
86Ulnar bowing (HP:0003031)1.87576376
87Right ventricular cardiomyopathy (HP:0011663)1.85949386
88Abnormal ossification of hand bones (HP:0005921)1.84605661
89Distal lower limb amyotrophy (HP:0008944)1.84443752
90Hyperacusis (HP:0010780)1.83827871
91Mitral regurgitation (HP:0001653)1.81676600
92Abnormality of the 4th metacarpal (HP:0010012)1.81321726
93* Coxa vara (HP:0002812)1.81241402
94Delayed cranial suture closure (HP:0000270)1.80388313
95Lumbar hyperlordosis (HP:0002938)1.80335487
96Aortic regurgitation (HP:0001659)1.79477253
97Abnormality of skeletal muscle fiber size (HP:0012084)1.78983667
98Deep venous thrombosis (HP:0002625)1.78322563
99Hematochezia (HP:0002573)1.78074149
100Long toe (HP:0010511)1.78068647
101Wide anterior fontanel (HP:0000260)1.77867644
102Trismus (HP:0000211)1.77507893
103Difficulty climbing stairs (HP:0003551)1.77425429
104Generalized amyotrophy (HP:0003700)1.76788784
105Ovoid vertebral bodies (HP:0003300)1.76603890
106Abnormality of nail color (HP:0100643)1.76551322
107Urinary glycosaminoglycan excretion (HP:0003541)1.76529931
108Mucopolysacchariduria (HP:0008155)1.76529931
109Follicular hyperkeratosis (HP:0007502)1.76482621
110Slender build (HP:0001533)1.76361904
111Asymmetric septal hypertrophy (HP:0001670)1.75917164
112Abnormality of the calcaneus (HP:0008364)1.75576582
113Nail dystrophy (HP:0008404)1.74655883
114Polycythemia (HP:0001901)1.74135073
115Inguinal hernia (HP:0000023)1.74103289
116Coronal craniosynostosis (HP:0004440)1.73768750
117Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73557138
118Thin skin (HP:0000963)1.72255615
119Protruding ear (HP:0000411)1.70602828
120Overgrowth (HP:0001548)1.69701098
121Disproportionate tall stature (HP:0001519)1.68910109
122Vertebral arch anomaly (HP:0008438)1.68173606
123Arachnodactyly (HP:0001166)1.67214164
124Camptodactyly of toe (HP:0001836)1.67206979
125Broad palm (HP:0001169)1.67111256
126Dysostosis multiplex (HP:0000943)1.66202525
127Knee flexion contracture (HP:0006380)1.65954971
128Achilles tendon contracture (HP:0001771)1.65848108
129Congenital glaucoma (HP:0001087)1.65074690
130Cupped ribs (HP:0000887)1.64926562
131Abnormality of the Achilles tendon (HP:0005109)1.64890428
132Tibial bowing (HP:0002982)1.63296029
133Entropion (HP:0000621)1.61648593
134Insomnia (HP:0100785)1.59850513
135Absent frontal sinuses (HP:0002688)1.58641554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.97309487
2ERN13.88024738
3PKN23.71977572
4NTRK12.73903934
5TTN2.71154691
6SIK12.64910061
7TGFBR22.52947655
8EEF2K2.38436060
9KDR2.30516137
10PDGFRA2.29225260
11DDR22.28352632
12MAP3K102.15286703
13PTK62.07652043
14RIPK11.90486716
15LRRK21.90221738
16SCYL21.88805110
17PAK41.86981582
18FLT31.78413980
19TGFBR11.74935048
20IRAK31.70847462
21ARAF1.67747674
22RPS6KA41.59083691
23EPHA31.47545094
24MST1R1.47530028
25LATS11.43894764
26PTK21.40481610
27SMG11.38530006
28ERBB41.36557978
29TIE11.33898911
30MAP2K31.31335661
31FGFR41.31075488
32PAK21.30588558
33MET1.30384098
34STK381.17766240
35EPHB21.17680684
36STK101.16843251
37JAK31.10572957
38NME21.10079772
39EPHB11.09129764
40MTOR1.09033716
41CAMK1D1.08890471
42BMX1.08855511
43MAP3K111.08594511
44BCKDK1.06200592
45MAP3K121.05861766
46LATS21.03224359
47KIT1.02058447
48PRKD20.99926271
49EPHA20.99004677
50ZAP700.98106617
51TAOK10.94024954
52LMTK20.93050269
53KSR20.92099707
54TESK10.91944566
55MAP3K60.91511321
56PRPF4B0.90259585
57MAPKAPK30.90156665
58NEK90.89947565
59FER0.89505315
60ILK0.88142880
61PBK0.87198557
62DMPK0.86678772
63ABL20.86439179
64STK38L0.85096680
65ROCK20.83113456
66MAP3K70.81742135
67NEK10.80516490
68MYLK0.79641721
69TAOK20.79496688
70CDC42BPA0.79491412
71MAP3K80.79274296
72RPS6KB20.78910757
73CDK60.78565612
74RET0.77938918
75PIM20.77075277
76PDGFRB0.76979634
77FGFR10.76598275
78CLK10.75521623
79DYRK1B0.68938051
80MOS0.67848229
81MAP3K30.67670810
82NEK20.67016582
83RPS6KA20.64872566
84MAP4K10.64841585
85TBK10.64703741
86MAP3K20.63813930
87CSF1R0.61730268
88PIK3CA0.61340563
89JAK10.59727223
90PRKG20.59157975
91TYK20.58650543
92TRPM70.57138562
93EIF2AK10.56354586
94BRAF0.55779467
95CDK80.55310662
96CDK40.52781912
97ROCK10.51578119
98TESK20.50920950
99PASK0.50664052
100CDK120.50163102
101PIK3CG0.48605172
102MAP2K20.47577229
103STK30.46449466
104MAP2K10.46181591
105MAPK110.45980212
106KSR10.43962920
107AKT30.43567770
108ERBB20.43402878
109BTK0.43306618
110GSK3A0.42532683
111BUB10.41913705
112MAP3K10.41661177
113CAMK1G0.41437987
114PAK30.40621543
115LIMK10.40542861
116CAMKK10.40059227
117PTK2B0.38114986
118RAF10.37525912
119MATK0.37099802
120JAK20.36386505
121PRKCH0.36297781
122CDK70.36067851
123PAK60.35146832
124DAPK30.34552200
125CHUK0.34521694
126CAMKK20.33247743
127CAMK2G0.32691519
128ICK0.32154982
129PRKD10.31928751
130PAK10.31795168
131SRC0.31446162
132TTK0.27832018
133MAPKAPK20.27442303
134BCR0.25687325
135BRSK10.24601162
136CDK90.23579163

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.95557732
2Focal adhesion_Homo sapiens_hsa045102.26803794
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95910150
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95365287
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88689881
6Small cell lung cancer_Homo sapiens_hsa052221.88606320
7Proteoglycans in cancer_Homo sapiens_hsa052051.84725658
8Chronic myeloid leukemia_Homo sapiens_hsa052201.78044026
9N-Glycan biosynthesis_Homo sapiens_hsa005101.75510261
10Sulfur relay system_Homo sapiens_hsa041221.72821880
11Bladder cancer_Homo sapiens_hsa052191.72389588
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71642052
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.66792873
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66510841
15Protein digestion and absorption_Homo sapiens_hsa049741.62116559
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60184003
17Adherens junction_Homo sapiens_hsa045201.49705456
18Amoebiasis_Homo sapiens_hsa051461.49630585
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47546091
20Fatty acid degradation_Homo sapiens_hsa000711.44731611
21Prion diseases_Homo sapiens_hsa050201.43005797
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.36957841
23Selenocompound metabolism_Homo sapiens_hsa004501.31385555
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28235301
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26681196
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.24786582
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20373438
28Thyroid cancer_Homo sapiens_hsa052161.19471347
29Vibrio cholerae infection_Homo sapiens_hsa051101.18134037
30Nitrogen metabolism_Homo sapiens_hsa009101.17968608
31Dilated cardiomyopathy_Homo sapiens_hsa054141.17781979
32Insulin resistance_Homo sapiens_hsa049311.16768586
33Shigellosis_Homo sapiens_hsa051311.15392651
34Galactose metabolism_Homo sapiens_hsa000521.14285366
35Lysine degradation_Homo sapiens_hsa003101.10037500
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08183452
37Acute myeloid leukemia_Homo sapiens_hsa052211.07843658
38p53 signaling pathway_Homo sapiens_hsa041151.06268435
39Lysosome_Homo sapiens_hsa041421.05976599
40Fructose and mannose metabolism_Homo sapiens_hsa000511.05011508
41Complement and coagulation cascades_Homo sapiens_hsa046101.04139971
42MicroRNAs in cancer_Homo sapiens_hsa052061.04093985
43Basal cell carcinoma_Homo sapiens_hsa052171.03883786
44Viral myocarditis_Homo sapiens_hsa054161.03316531
45Pancreatic cancer_Homo sapiens_hsa052121.02451867
46Other glycan degradation_Homo sapiens_hsa005111.02410091
47Toxoplasmosis_Homo sapiens_hsa051451.01850811
48Sulfur metabolism_Homo sapiens_hsa009201.00097926
49Fatty acid metabolism_Homo sapiens_hsa012121.00061438
50Hippo signaling pathway_Homo sapiens_hsa043900.99806704
51Sphingolipid metabolism_Homo sapiens_hsa006000.99461383
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98319308
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95889534
54HTLV-I infection_Homo sapiens_hsa051660.95107856
55Melanoma_Homo sapiens_hsa052180.94268551
56Carbon metabolism_Homo sapiens_hsa012000.94107031
57Axon guidance_Homo sapiens_hsa043600.92112769
58Platelet activation_Homo sapiens_hsa046110.91249743
59Renin-angiotensin system_Homo sapiens_hsa046140.90717605
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89553469
61TGF-beta signaling pathway_Homo sapiens_hsa043500.89137883
62Biosynthesis of amino acids_Homo sapiens_hsa012300.88974157
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88086383
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.85601591
65Salmonella infection_Homo sapiens_hsa051320.85183965
66mTOR signaling pathway_Homo sapiens_hsa041500.83676114
67Notch signaling pathway_Homo sapiens_hsa043300.82983739
68PPAR signaling pathway_Homo sapiens_hsa033200.82835335
69Renal cell carcinoma_Homo sapiens_hsa052110.82600499
70Tight junction_Homo sapiens_hsa045300.81067051
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80021324
72Pathways in cancer_Homo sapiens_hsa052000.78784734
73Malaria_Homo sapiens_hsa051440.76723584
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76319199
75AMPK signaling pathway_Homo sapiens_hsa041520.76211404
76Colorectal cancer_Homo sapiens_hsa052100.74063439
77HIF-1 signaling pathway_Homo sapiens_hsa040660.73640321
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.72525437
79Starch and sucrose metabolism_Homo sapiens_hsa005000.71852138
80Hedgehog signaling pathway_Homo sapiens_hsa043400.70892344
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70153567
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69906589
83Tryptophan metabolism_Homo sapiens_hsa003800.67616553
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.67421936
85VEGF signaling pathway_Homo sapiens_hsa043700.67101694
86Hepatitis B_Homo sapiens_hsa051610.66969069
87Insulin signaling pathway_Homo sapiens_hsa049100.64630817
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64426452
89Apoptosis_Homo sapiens_hsa042100.64363536
90ErbB signaling pathway_Homo sapiens_hsa040120.63977763
91Pentose phosphate pathway_Homo sapiens_hsa000300.63851131
92Antigen processing and presentation_Homo sapiens_hsa046120.62618942
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61779331
94Endometrial cancer_Homo sapiens_hsa052130.61606651
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61577017
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60774379
97Vitamin B6 metabolism_Homo sapiens_hsa007500.60598734
98Viral carcinogenesis_Homo sapiens_hsa052030.60441177
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60261484
100Endocytosis_Homo sapiens_hsa041440.60030732
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59949342
102TNF signaling pathway_Homo sapiens_hsa046680.59524173
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59491646
104Caffeine metabolism_Homo sapiens_hsa002320.59444659
105Gap junction_Homo sapiens_hsa045400.59238686
106Steroid biosynthesis_Homo sapiens_hsa001000.59146176
107Folate biosynthesis_Homo sapiens_hsa007900.57545303
108* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56414845
109Bile secretion_Homo sapiens_hsa049760.56272864
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56238843
111Prostate cancer_Homo sapiens_hsa052150.55739799
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55732999
113Leishmaniasis_Homo sapiens_hsa051400.55517994
114Rap1 signaling pathway_Homo sapiens_hsa040150.55356763
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55310914
116Non-small cell lung cancer_Homo sapiens_hsa052230.54927958
117Melanogenesis_Homo sapiens_hsa049160.52330069
118Glutathione metabolism_Homo sapiens_hsa004800.51644051
119One carbon pool by folate_Homo sapiens_hsa006700.51233406
120Glioma_Homo sapiens_hsa052140.51179378
121Cell cycle_Homo sapiens_hsa041100.50720146
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47556039
123Pertussis_Homo sapiens_hsa051330.46374179
124Thyroid hormone synthesis_Homo sapiens_hsa049180.46363206
125Hepatitis C_Homo sapiens_hsa051600.46348020
126Estrogen signaling pathway_Homo sapiens_hsa049150.41475156
127Inositol phosphate metabolism_Homo sapiens_hsa005620.38230548
128Wnt signaling pathway_Homo sapiens_hsa043100.37835630
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.35520062

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