EXTL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)4.46800676
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34517120
3L-amino acid import (GO:0043092)4.15067379
4membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13805149
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.07507753
6vocalization behavior (GO:0071625)4.06655565
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04660136
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.03324986
9dendritic spine morphogenesis (GO:0060997)4.01158852
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00880124
11cerebellar granule cell differentiation (GO:0021707)3.91830661
12regulation of glutamate receptor signaling pathway (GO:1900449)3.91502386
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.90014487
14neurotransmitter-gated ion channel clustering (GO:0072578)3.89656580
15glutamate secretion (GO:0014047)3.87500422
16amino acid import (GO:0043090)3.76216982
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.74553549
18locomotory exploration behavior (GO:0035641)3.62031823
19positive regulation of dendritic spine development (GO:0060999)3.61890804
20positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.61794254
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.60293578
22dendritic spine organization (GO:0097061)3.58053881
23neurotransmitter transport (GO:0006836)3.55657091
24glutamate receptor signaling pathway (GO:0007215)3.51528335
25negative regulation of dendrite morphogenesis (GO:0050774)3.47124178
26regulation of neurotransmitter secretion (GO:0046928)3.44716168
27regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.43431548
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41804451
29positive regulation of neurotransmitter transport (GO:0051590)3.41402451
30protein localization to synapse (GO:0035418)3.39939385
31synaptic transmission, glutamatergic (GO:0035249)3.38684352
32postsynaptic membrane organization (GO:0001941)3.38017471
33neuromuscular process controlling balance (GO:0050885)3.35962779
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.34905275
35regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.34783159
36neuronal ion channel clustering (GO:0045161)3.34321197
37cell communication by electrical coupling (GO:0010644)3.34194741
38synaptic vesicle exocytosis (GO:0016079)3.33600649
39regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.33009104
40G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29115986
41detection of calcium ion (GO:0005513)3.28719197
42neuromuscular synaptic transmission (GO:0007274)3.28029268
43regulation of dendritic spine development (GO:0060998)3.27321800
44synaptic vesicle maturation (GO:0016188)3.26084480
45regulation of neurotransmitter levels (GO:0001505)3.25834773
46positive regulation of membrane potential (GO:0045838)3.25673179
47regulation of ARF protein signal transduction (GO:0032012)3.24719954
48layer formation in cerebral cortex (GO:0021819)3.24065073
49potassium ion homeostasis (GO:0055075)3.23812475
50sarcoplasmic reticulum calcium ion transport (GO:0070296)3.23188681
51neuronal action potential propagation (GO:0019227)3.21417683
52regulation of neuronal synaptic plasticity (GO:0048168)3.20386993
53potassium ion import (GO:0010107)3.17684608
54regulation of cell communication by electrical coupling (GO:0010649)3.17094440
55cell communication involved in cardiac conduction (GO:0086065)3.14432709
56cytoskeletal anchoring at plasma membrane (GO:0007016)3.13893124
57activation of protein kinase A activity (GO:0034199)3.12082364
58regulation of neurotransmitter transport (GO:0051588)3.11590878
59myofibril assembly (GO:0030239)3.10891925
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10888652
61cardiac myofibril assembly (GO:0055003)3.10611907
62neuron-neuron synaptic transmission (GO:0007270)3.09972935
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.08917647
64regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.08279093
65regulation of skeletal muscle contraction (GO:0014819)3.08054505
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.05780987
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05076356
68regulation of synaptic vesicle transport (GO:1902803)3.03831747
69long-term memory (GO:0007616)3.01399965
70central nervous system myelination (GO:0022010)2.95824744
71axon ensheathment in central nervous system (GO:0032291)2.95824744
72cardiac conduction (GO:0061337)2.94800039
73chemosensory behavior (GO:0007635)2.93631423
74regulation of vesicle fusion (GO:0031338)2.91791596
75regulation of postsynaptic membrane potential (GO:0060078)2.91549225
76cardiac muscle contraction (GO:0060048)2.91381072
77cerebellar Purkinje cell differentiation (GO:0021702)2.91332915
78regulation of membrane repolarization (GO:0060306)2.91252739
79cardiac muscle hypertrophy (GO:0003300)2.89477445
80proline transport (GO:0015824)2.87340060
81striated muscle contraction (GO:0006941)2.87123163
82regulation of synaptic vesicle exocytosis (GO:2000300)2.87015200
83sarcomere organization (GO:0045214)2.86545146
84ventricular cardiac muscle cell action potential (GO:0086005)2.85998450
85muscle filament sliding (GO:0030049)2.83693240
86actin-myosin filament sliding (GO:0033275)2.83693240
87positive regulation of neurotransmitter secretion (GO:0001956)2.83344275
88regulation of synaptic transmission (GO:0050804)2.82941075
89gamma-aminobutyric acid transport (GO:0015812)2.82803158
90positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82114610
91regulation of synapse structural plasticity (GO:0051823)2.81788169
92membrane depolarization during action potential (GO:0086010)2.81211073
93striated muscle hypertrophy (GO:0014897)2.80514200
94negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80166808
95cardiac muscle cell action potential (GO:0086001)2.79655139
96plasma membrane repair (GO:0001778)2.78905829
97positive regulation of dendrite development (GO:1900006)2.77741095
98exploration behavior (GO:0035640)2.77527971
99cellular sodium ion homeostasis (GO:0006883)2.76259348
100positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.75500947
101regulation of synaptic plasticity (GO:0048167)2.75364076
102neurotransmitter secretion (GO:0007269)2.74997082
103acidic amino acid transport (GO:0015800)2.74861266
104response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.72989020
105regulation of dendrite morphogenesis (GO:0048814)2.72490516
106regulation of calcium ion transmembrane transport (GO:1903169)2.72269663
107regulation of calcium ion transmembrane transporter activity (GO:1901019)2.72269663
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70849820
109cardiac muscle cell action potential involved in contraction (GO:0086002)2.70268791
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.70137363
111cellular potassium ion homeostasis (GO:0030007)2.67907079
112long-term synaptic potentiation (GO:0060291)2.66435512
113positive regulation of synapse maturation (GO:0090129)2.65957720
114synaptic vesicle endocytosis (GO:0048488)2.63110074
115regulation of heart rate by cardiac conduction (GO:0086091)2.61716531
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.61260875
117neuron cell-cell adhesion (GO:0007158)2.61236258
118regulation of synapse maturation (GO:0090128)2.59908673
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.59523207
120skeletal muscle contraction (GO:0003009)2.58364602
121membrane depolarization (GO:0051899)2.57500580
122long term synaptic depression (GO:0060292)2.57385804
123female mating behavior (GO:0060180)2.57167929
124regulation of dendritic spine morphogenesis (GO:0061001)2.54635901
125adrenergic receptor signaling pathway (GO:0071875)2.54203424
126regulation of voltage-gated calcium channel activity (GO:1901385)2.53706085
127muscle hypertrophy (GO:0014896)2.52950755
128dicarboxylic acid biosynthetic process (GO:0043650)2.52414550
129auditory behavior (GO:0031223)2.51795857
130regulation of relaxation of muscle (GO:1901077)2.51372630
131behavioral response to cocaine (GO:0048148)2.50892726
132regulation of actin filament-based movement (GO:1903115)2.50530293
133regulation of female receptivity (GO:0045924)2.48944520
134bundle of His cell to Purkinje myocyte communication (GO:0086069)2.48457264
135cardiac muscle adaptation (GO:0014887)2.46842464
136cardiac muscle hypertrophy in response to stress (GO:0014898)2.46842464
137muscle hypertrophy in response to stress (GO:0003299)2.46842464
138negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.46738845
139regulation of ion transmembrane transporter activity (GO:0032412)2.46465379
140presynaptic membrane organization (GO:0097090)2.46040133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09068549
2GBX2_23144817_ChIP-Seq_PC3_Human3.40788765
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.89364302
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47251097
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36569582
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30113384
7DROSHA_22980978_ChIP-Seq_HELA_Human2.26860256
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16077580
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14659052
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11481244
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11481244
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09098914
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04755137
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01471561
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99070769
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91864492
17KDM2B_26808549_Chip-Seq_K562_Human1.91741066
18ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91529922
19DNAJC2_21179169_ChIP-ChIP_NT2_Human1.90563975
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.90227466
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.89165386
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.82780912
23* REST_21632747_ChIP-Seq_MESCs_Mouse1.82142837
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.81034936
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80208327
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77789545
27* RNF2_27304074_Chip-Seq_ESCs_Mouse1.74777837
28* LXR_22292898_ChIP-Seq_THP-1_Human1.74674899
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74278111
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71460485
31AR_21572438_ChIP-Seq_LNCaP_Human1.70949207
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69094866
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.62255334
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61138350
35* CTCF_27219007_Chip-Seq_Bcells_Human1.60910631
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60282001
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.60196615
38* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.57110132
39SMAD4_21799915_ChIP-Seq_A2780_Human1.56725409
40TET1_21490601_ChIP-Seq_MESCs_Mouse1.53721288
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48088444
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48052195
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46542409
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44789309
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44637688
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41349755
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40676619
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39582579
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.36390769
50TAF15_26573619_Chip-Seq_HEK293_Human1.36206357
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35016078
52P300_19829295_ChIP-Seq_ESCs_Human1.33151791
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32783870
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30909855
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27473669
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.27100907
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25969479
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24626770
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.22090902
60AHR_22903824_ChIP-Seq_MCF-7_Human1.22002409
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.20922694
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.20149727
63SMC4_20622854_ChIP-Seq_HELA_Human1.20024220
64* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19649720
65AR_25329375_ChIP-Seq_VCAP_Human1.18859936
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18060443
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17795843
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.17201075
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17031549
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16953040
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16920303
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16920303
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16362527
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15901502
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.15454365
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13973230
77STAT3_23295773_ChIP-Seq_U87_Human1.11319621
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09401697
79SMAD3_21741376_ChIP-Seq_HESCs_Human1.09146708
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09106149
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08860908
82* CBX2_27304074_Chip-Seq_ESCs_Mouse1.08816344
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08586490
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08562663
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08415752
86TCF4_23295773_ChIP-Seq_U87_Human1.08384309
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.07846419
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.07826384
89* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07328865
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07263959
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07176107
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07120864
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.07082125
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06795268
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.05832950
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05733607
97OCT4_19829295_ChIP-Seq_ESCs_Human1.05144117
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05029258
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04644817
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.04243463
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04144755
102AR_19668381_ChIP-Seq_PC3_Human1.03882146
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.03606456
104* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03337423
105BCAT_22108803_ChIP-Seq_LS180_Human1.03259628
106TP53_16413492_ChIP-PET_HCT116_Human1.03048388
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02658108
108KDM2B_26808549_Chip-Seq_DND41_Human1.02283026
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01939661
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.01875086
111RXR_22108803_ChIP-Seq_LS180_Human1.01219278
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00855318
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00661587
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00471601
115TP53_18474530_ChIP-ChIP_U2OS_Human1.00001800
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99788170
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99336818
118TP53_23651856_ChIP-Seq_MEFs_Mouse0.99185109
119P53_22387025_ChIP-Seq_ESCs_Mouse0.98078529
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97459646
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.97020581
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96902729
123P68_20966046_ChIP-Seq_HELA_Human0.96692193
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.96381689
125* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96055133
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95488525
127VDR_22108803_ChIP-Seq_LS180_Human0.95455352
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95149585
129CREB1_26743006_Chip-Seq_LNCaP_Human0.94725764
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93821574
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92645888
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.92241381
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92196781
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91717993
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91531679
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.90258873
137DPY_21335234_ChIP-Seq_ESCs_Mouse0.89746985
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.89124661
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87991926
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.87146413
141TBX20_22080862_ChIP-Seq_HEART_Mouse0.87146413
142EGR1_19032775_ChIP-ChIP_M12_Human0.84906934
143KLF4_19829295_ChIP-Seq_ESCs_Human0.84891478
144CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84201590
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83885628
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.82049943
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81017760
148* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80919910
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80861510
150SA1_27219007_Chip-Seq_ERYTHROID_Human0.80427485
151TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80080855
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79888957
153* RACK7_27058665_Chip-Seq_MCF-7_Human0.79748585
154GATA1_26923725_Chip-Seq_HPCs_Mouse0.77366776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.37754482
2MP0002837_dystrophic_cardiac_calcinosis3.66688266
3MP0003646_muscle_fatigue3.65782719
4MP0003880_abnormal_central_pattern3.62479827
5MP0002822_catalepsy3.42872322
6MP0000751_myopathy3.26846532
7MP0003635_abnormal_synaptic_transmissio3.05921939
8MP0002254_reproductive_system_inflammat2.94654730
9MP0004510_myositis2.86909910
10MP0009745_abnormal_behavioral_response2.78327702
11MP0005171_absent_coat_pigmentation2.54645830
12MP0002063_abnormal_learning/memory/cond2.53096228
13MP0000749_muscle_degeneration2.39236219
14MP0004215_abnormal_myocardial_fiber2.39141035
15MP0004270_analgesia2.37948839
16MP0004145_abnormal_muscle_electrophysio2.32431175
17MP0002064_seizures2.26536790
18MP0001501_abnormal_sleep_pattern2.26453747
19MP0009046_muscle_twitch2.17882337
20MP0001968_abnormal_touch/_nociception2.14676966
21MP0004036_abnormal_muscle_relaxation2.12784288
22MP0002572_abnormal_emotion/affect_behav2.03955774
23MP0001486_abnormal_startle_reflex1.99001510
24MP0002736_abnormal_nociception_after1.97231744
25MP0003879_abnormal_hair_cell1.88744857
26MP0002876_abnormal_thyroid_physiology1.86599381
27MP0002735_abnormal_chemical_nociception1.83126580
28MP0002272_abnormal_nervous_system1.81569676
29MP0005646_abnormal_pituitary_gland1.79449184
30MP0004484_altered_response_of1.75488017
31MP0004084_abnormal_cardiac_muscle1.69197723
32MP0005620_abnormal_muscle_contractility1.64638852
33MP0001440_abnormal_grooming_behavior1.60865478
34MP0002734_abnormal_mechanical_nocicepti1.58286196
35MP0005645_abnormal_hypothalamus_physiol1.56020707
36MP0005330_cardiomyopathy1.53725961
37MP0000920_abnormal_myelination1.50965365
38MP0004130_abnormal_muscle_cell1.49048832
39MP0003137_abnormal_impulse_conducting1.44693951
40MP0002106_abnormal_muscle_physiology1.43405927
41MP0000569_abnormal_digit_pigmentation1.43095594
42MP0002972_abnormal_cardiac_muscle1.40829904
43MP0009780_abnormal_chondrocyte_physiolo1.40311264
44MP0004858_abnormal_nervous_system1.39162174
45MP0004085_abnormal_heartbeat1.36831582
46MP0005085_abnormal_gallbladder_physiolo1.36427624
47MP0008569_lethality_at_weaning1.36366912
48MP0004087_abnormal_muscle_fiber1.34456154
49MP0001502_abnormal_circadian_rhythm1.33857819
50MP0003705_abnormal_hypodermis_morpholog1.31902914
51MP0005623_abnormal_meninges_morphology1.31848102
52MP0002067_abnormal_sensory_capabilities1.30763005
53MP0002269_muscular_atrophy1.24611881
54MP0005386_behavior/neurological_phenoty1.23287299
55MP0004924_abnormal_behavior1.23287299
56MP0003690_abnormal_glial_cell1.22460309
57MP0005369_muscle_phenotype1.20781649
58MP0001984_abnormal_olfaction1.18621274
59MP0005423_abnormal_somatic_nervous1.17294230
60MP0002909_abnormal_adrenal_gland1.14179021
61MP0002557_abnormal_social/conspecific_i1.10710871
62MP0005535_abnormal_body_temperature1.10466078
63MP0003075_altered_response_to1.10218831
64MP0003634_abnormal_glial_cell1.09419797
65MP0000955_abnormal_spinal_cord1.07335858
66MP0008874_decreased_physiological_sensi1.05370614
67MP0000013_abnormal_adipose_tissue1.03531958
68MP0001970_abnormal_pain_threshold1.03423193
69MP0001299_abnormal_eye_distance/1.02779219
70MP0006138_congestive_heart_failure1.02509486
71MP0001905_abnormal_dopamine_level1.02369159
72MP0001188_hyperpigmentation1.00222506
73MP0003633_abnormal_nervous_system1.00114763
74MP0000747_muscle_weakness0.98775702
75MP0000759_abnormal_skeletal_muscle0.98390887
76MP0002184_abnormal_innervation0.97141935
77MP0001346_abnormal_lacrimal_gland0.95778398
78MP0002733_abnormal_thermal_nociception0.95705235
79MP0008775_abnormal_heart_ventricle0.95685701
80MP0002229_neurodegeneration0.91338786
81MP0002332_abnormal_exercise_endurance0.91280135
82MP0005365_abnormal_bile_salt0.90963099
83MP0005385_cardiovascular_system_phenoty0.88406410
84MP0001544_abnormal_cardiovascular_syste0.88406410
85MP0000750_abnormal_muscle_regeneration0.87430491
86MP0008872_abnormal_physiological_respon0.86850254
87MP0001963_abnormal_hearing_physiology0.86791595
88MP0002066_abnormal_motor_capabilities/c0.85938140
89MP0002152_abnormal_brain_morphology0.82561548
90MP0003329_amyloid_beta_deposits0.82057249
91MP0003123_paternal_imprinting0.80972268
92MP0003787_abnormal_imprinting0.80941492
93MP0010386_abnormal_urinary_bladder0.80824015
94MP0005409_darkened_coat_color0.79019222
95MP0005670_abnormal_white_adipose0.77582385
96MP0003172_abnormal_lysosome_physiology0.76587900
97MP0000579_abnormal_nail_morphology0.76405275
98MP0004233_abnormal_muscle_weight0.76053404
99MP0003631_nervous_system_phenotype0.75282299
100MP0008438_abnormal_cutaneous_collagen0.75066294
101MP0004811_abnormal_neuron_physiology0.74108467
102MP0000733_abnormal_muscle_development0.73737741
103MP0001348_abnormal_lacrimal_gland0.73082551
104MP0000778_abnormal_nervous_system0.72834937
105MP0004142_abnormal_muscle_tone0.70489599
106MP0008961_abnormal_basal_metabolism0.69918312
107MP0002069_abnormal_eating/drinking_beha0.69390242
108MP0000604_amyloidosis0.68920680
109MP0005167_abnormal_blood-brain_barrier0.68746224
110MP0001529_abnormal_vocalization0.66977893
111MP0001177_atelectasis0.66577709
112MP0005310_abnormal_salivary_gland0.64484616
113MP0003632_abnormal_nervous_system0.63936358
114MP0002249_abnormal_larynx_morphology0.63225246
115MP0006276_abnormal_autonomic_nervous0.62672698
116MP0003045_fibrosis0.61568876
117MP0002234_abnormal_pharynx_morphology0.61487273
118MP0002108_abnormal_muscle_morphology0.60536880
119MP0004742_abnormal_vestibular_system0.59307001
120MP0002882_abnormal_neuron_morphology0.58825829
121MP0004885_abnormal_endolymph0.58747405
122MP0005166_decreased_susceptibility_to0.58424634
123MP0010630_abnormal_cardiac_muscle0.57445805
124MP0010329_abnormal_lipoprotein_level0.57349127

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.82107008
2Exercise-induced myalgia (HP:0003738)5.27245386
3Calf muscle hypertrophy (HP:0008981)5.15891217
4Sudden death (HP:0001699)5.02153013
5Muscle hypertrophy of the lower extremities (HP:0008968)4.91658039
6Febrile seizures (HP:0002373)4.60062050
7Abnormality of the calf musculature (HP:0001430)4.15908160
8Focal seizures (HP:0007359)4.04919011
9Myokymia (HP:0002411)3.98854545
10Epileptic encephalopathy (HP:0200134)3.96909944
11Right ventricular cardiomyopathy (HP:0011663)3.91857781
12Atrial fibrillation (HP:0005110)3.81887944
13Syncope (HP:0001279)3.80330693
14Obstructive sleep apnea (HP:0002870)3.78711407
15Supranuclear gaze palsy (HP:0000605)3.68900066
16Exercise-induced muscle cramps (HP:0003710)3.60431587
17Ankle clonus (HP:0011448)3.59661887
18Primary atrial arrhythmia (HP:0001692)3.54960933
19Bundle branch block (HP:0011710)3.50274153
20Hyperventilation (HP:0002883)3.43366668
21Diplopia (HP:0000651)3.37801791
22Abnormality of binocular vision (HP:0011514)3.37801791
23Ventricular tachycardia (HP:0004756)3.36694366
24Atonic seizures (HP:0010819)3.35268994
25Supraventricular tachycardia (HP:0004755)3.31445760
26Ventricular fibrillation (HP:0001663)3.26990651
27Peripheral hypomyelination (HP:0007182)3.22292547
28Cerebral hypomyelination (HP:0006808)3.21889937
29Generalized tonic-clonic seizures (HP:0002069)3.18550229
30Prolonged QT interval (HP:0001657)3.18174157
31Hyporeflexia of lower limbs (HP:0002600)3.18063771
32Supraventricular arrhythmia (HP:0005115)3.17975029
33Muscle fiber inclusion bodies (HP:0100299)3.14170049
34EMG: myopathic abnormalities (HP:0003458)3.11497971
35Ventricular arrhythmia (HP:0004308)3.10468802
36Neurofibrillary tangles (HP:0002185)3.07547747
37Muscle fiber splitting (HP:0003555)3.04127073
38Round ear (HP:0100830)3.00098522
39Heart block (HP:0012722)2.97566346
40Absence seizures (HP:0002121)2.96531717
41Type 1 muscle fiber predominance (HP:0003803)2.91441144
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.89401573
43Dialeptic seizures (HP:0011146)2.77581944
44Abnormal EKG (HP:0003115)2.76510170
45Abnormal atrioventricular conduction (HP:0005150)2.76442376
46Broad-based gait (HP:0002136)2.76377950
47Torticollis (HP:0000473)2.76354895
48Annular pancreas (HP:0001734)2.76061728
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.74454938
50Fetal akinesia sequence (HP:0001989)2.71764952
51Postural instability (HP:0002172)2.71076507
52Visual hallucinations (HP:0002367)2.69662971
53Spastic gait (HP:0002064)2.68854798
54Distal lower limb amyotrophy (HP:0008944)2.66656010
55Upper limb amyotrophy (HP:0009129)2.60415691
56Distal upper limb amyotrophy (HP:0007149)2.60415691
57Distal lower limb muscle weakness (HP:0009053)2.56854202
58Cerebral inclusion bodies (HP:0100314)2.56160502
59Nemaline bodies (HP:0003798)2.55119691
60Myoglobinuria (HP:0002913)2.51005639
61Lower limb amyotrophy (HP:0007210)2.50142362
62Impaired vibration sensation in the lower limbs (HP:0002166)2.48867468
63Subaortic stenosis (HP:0001682)2.48230044
64Abnormality of the left ventricular outflow tract (HP:0011103)2.48230044
65Distal arthrogryposis (HP:0005684)2.46924253
66Dysmetric saccades (HP:0000641)2.41416162
67Poor eye contact (HP:0000817)2.37881706
68Tetraplegia (HP:0002445)2.36997893
69Stridor (HP:0010307)2.34062019
70Progressive cerebellar ataxia (HP:0002073)2.33339734
71Atrioventricular block (HP:0001678)2.33296184
72Gaze-evoked nystagmus (HP:0000640)2.33239108
73Akinesia (HP:0002304)2.31910918
74Hand muscle atrophy (HP:0009130)2.31302853
75Muscle stiffness (HP:0003552)2.29024778
76Testicular atrophy (HP:0000029)2.28767403
77Foot dorsiflexor weakness (HP:0009027)2.27849562
78Left ventricular hypertrophy (HP:0001712)2.26818529
79Delusions (HP:0000746)2.25804620
80Lipoatrophy (HP:0100578)2.25767349
81Urinary urgency (HP:0000012)2.24587948
82Focal dystonia (HP:0004373)2.23459598
83Truncal ataxia (HP:0002078)2.23422073
84EMG: neuropathic changes (HP:0003445)2.21408225
85Abnormal eating behavior (HP:0100738)2.21085069
86Abnormality of the foot musculature (HP:0001436)2.20455679
87Abnormal social behavior (HP:0012433)2.20282485
88Impaired social interactions (HP:0000735)2.20282485
89Neuronal loss in central nervous system (HP:0002529)2.20009554
90Difficulty running (HP:0009046)2.19643267
91Fatigable weakness (HP:0003473)2.19091354
92Abnormality of the neuromuscular junction (HP:0003398)2.19091354
93Dilated cardiomyopathy (HP:0001644)2.18929184
94Papilledema (HP:0001085)2.17733635
95Frequent falls (HP:0002359)2.16711702
96Myotonia (HP:0002486)2.14040313
97Lower limb muscle weakness (HP:0007340)2.11361084
98Increased connective tissue (HP:0009025)2.10616754
99Sleep apnea (HP:0010535)2.10510331
100Rigidity (HP:0002063)2.07503213
101Craniofacial dystonia (HP:0012179)2.07066638
102Fair hair (HP:0002286)2.04577935
103Palpitations (HP:0001962)2.04395400
104Mildly elevated creatine phosphokinase (HP:0008180)2.03781107
105Status epilepticus (HP:0002133)2.03423197
106Cerebral aneurysm (HP:0004944)2.01897942
107Intention tremor (HP:0002080)2.00874306
108Dysdiadochokinesis (HP:0002075)1.99812636
109Limb dystonia (HP:0002451)1.99641986
110Hemiplegia (HP:0002301)1.98349147
111Urinary bladder sphincter dysfunction (HP:0002839)1.98314681
112Hypoplasia of the iris (HP:0007676)1.97420027
113Blue irides (HP:0000635)1.97227110
114Difficulty climbing stairs (HP:0003551)1.97021584
115Hip contracture (HP:0003273)1.96965216
116Asymmetric septal hypertrophy (HP:0001670)1.96447693
117Rapidly progressive (HP:0003678)1.96374756
118Impaired vibratory sensation (HP:0002495)1.91478770
119Rhabdomyolysis (HP:0003201)1.90963120
120Rimmed vacuoles (HP:0003805)1.89580744
121Anxiety (HP:0000739)1.88391480
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78644424
123Ketoacidosis (HP:0001993)1.78022115
124Depression (HP:0000716)1.76017436
125Hypoplastic ischia (HP:0003175)1.75353668
126Generalized hypopigmentation of hair (HP:0011358)1.74826229
127Dysmetria (HP:0001310)1.74443342
128Myopathic facies (HP:0002058)1.74338535
129Increased variability in muscle fiber diameter (HP:0003557)1.72363011
130Epileptiform EEG discharges (HP:0011182)1.71337024
131Inability to walk (HP:0002540)1.70960920
132Genetic anticipation (HP:0003743)1.69737650
133Muscular dystrophy (HP:0003560)1.69187995
134Hyperkalemia (HP:0002153)1.68973027
135Abnormality of skeletal muscle fiber size (HP:0012084)1.67995160
136Bradycardia (HP:0001662)1.66618614
137Cholelithiasis (HP:0001081)1.65700421
138Absent speech (HP:0001344)1.65542778
139Amblyopia (HP:0000646)1.65489030
140Double outlet right ventricle (HP:0001719)1.62314995
141Congenital malformation of the right heart (HP:0011723)1.62314995
142Neck muscle weakness (HP:0000467)1.61589077
143Action tremor (HP:0002345)1.61322199
144Confusion (HP:0001289)1.61111091
145Bradykinesia (HP:0002067)1.60707114
146Palmoplantar keratoderma (HP:0000982)1.60635224
147Hyperalaninemia (HP:0003348)1.60023400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.69669126
2NTRK33.22558467
3DAPK23.05324035
4OBSCN2.85650302
5MAP2K72.44595993
6CASK2.38956283
7MAP3K42.23150072
8PINK12.22085112
9NTRK12.15670826
10MAPK152.13092745
11RIPK42.11698597
12UHMK11.93601737
13BMPR21.84642325
14MAP2K41.81210317
15PHKG21.78528651
16PHKG11.78528651
17MAP3K131.75173124
18MUSK1.72581201
19PRKD31.70601326
20MAP3K91.69496140
21NME11.68969204
22TNIK1.53392817
23LATS21.51418522
24RIPK11.50234531
25INSRR1.49735750
26SGK21.48929132
27PRPF4B1.48922716
28DDR21.41462750
29MAP3K71.37739643
30STK381.33032010
31DAPK11.31832853
32DMPK1.31782423
33MAP3K141.23787001
34TTN1.23149555
35MARK21.22984056
36PLK21.21734215
37AKT31.21503236
38PAK61.17993449
39SGK31.16728587
40LMTK21.14170234
41PDK31.13242078
42PDK41.13242078
43CDK191.12368874
44NTRK21.11935817
45MAP3K121.10662800
46LIMK11.10359260
47TRIB31.09573532
48MAPK121.09103848
49MINK11.08213171
50CAMK2A1.06273849
51PTK2B1.05582599
52PDK21.03115858
53SGK4941.01603175
54SGK2231.01603175
55TIE11.01275532
56MAP3K111.00761972
57CAMK11.00271166
58GRK51.00197934
59CDK150.96581511
60CAMKK10.96493564
61PIK3CA0.96254640
62TESK10.95950856
63PRKCG0.95798273
64SGK10.94779971
65ARAF0.92639099
66CDK180.91203750
67CDK11A0.90075466
68PDK10.88111318
69CDK50.88009774
70PDPK10.87058810
71STK38L0.85462089
72ZAK0.84009539
73TAOK20.83235944
74TYRO30.79760274
75MAPK70.79311769
76MAPK130.78003590
77CDK140.77832839
78MAP3K60.77287230
79MAP2K60.76617687
80MYLK0.75928343
81KSR10.75189096
82PRKCE0.74295639
83TBK10.73630514
84CAMK40.73053471
85STK110.72153299
86PIK3CG0.70934259
87KSR20.70097412
88IKBKE0.69772280
89NEK60.69524510
90MAPK100.69154016
91ICK0.68613296
92BCKDK0.68586582
93PRKAA20.68226904
94CDC42BPA0.67742531
95DAPK30.67646392
96CDK30.67161467
97PKN10.66988683
98TAOK10.63811096
99SIK20.63004479
100CAMK2D0.62442869
101TNK20.62124032
102MOS0.60494327
103FER0.58956393
104CAMK2G0.57211641
105PAK30.56314424
106JAK10.56177955
107SIK30.55607977
108GRK70.55545355
109ROCK10.54980444
110CCNB10.53456106
111STK240.53201475
112PRKCH0.49934172
113MARK10.48502997
114PRKAA10.47381404
115CAMK2B0.46609066
116ALK0.46270522
117MAP3K10.45839558
118MAP3K30.45121553
119BRSK10.44996631
120ERBB20.44354309
121DYRK1A0.43478976
122MAP2K10.42463109
123BRAF0.42087226
124MAP3K50.40758697
125RPS6KA30.40681086
126PRKACA0.39120451
127MAPK40.38771016
128PRKG20.38184551
129PTK20.37970693
130SIK10.37146446
131ROCK20.36871596
132CAMKK20.33430805
133RAF10.32970152
134PRKD20.32453148
135PRKG10.32381186
136BMX0.32086212

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.16104905
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11090768
3Olfactory transduction_Homo sapiens_hsa047402.57667157
4Circadian entrainment_Homo sapiens_hsa047132.32217994
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22343271
6Morphine addiction_Homo sapiens_hsa050322.10175442
7Glutamatergic synapse_Homo sapiens_hsa047242.09174941
8Synaptic vesicle cycle_Homo sapiens_hsa047212.05352935
9Amphetamine addiction_Homo sapiens_hsa050311.96600904
10Calcium signaling pathway_Homo sapiens_hsa040201.93987919
11Salivary secretion_Homo sapiens_hsa049701.92790982
12Dilated cardiomyopathy_Homo sapiens_hsa054141.88631529
13Long-term potentiation_Homo sapiens_hsa047201.88503680
14GABAergic synapse_Homo sapiens_hsa047271.87336243
15Insulin secretion_Homo sapiens_hsa049111.82765982
16Cardiac muscle contraction_Homo sapiens_hsa042601.72499171
17Taste transduction_Homo sapiens_hsa047421.64978854
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61718422
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.57534166
20Oxytocin signaling pathway_Homo sapiens_hsa049211.54762547
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53341269
22Gastric acid secretion_Homo sapiens_hsa049711.52947034
23Renin secretion_Homo sapiens_hsa049241.48954718
24Vitamin B6 metabolism_Homo sapiens_hsa007501.48562218
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42191240
26Arginine biosynthesis_Homo sapiens_hsa002201.40971606
27Cholinergic synapse_Homo sapiens_hsa047251.31376600
28GnRH signaling pathway_Homo sapiens_hsa049121.20820894
29Dopaminergic synapse_Homo sapiens_hsa047281.20179327
30Serotonergic synapse_Homo sapiens_hsa047261.17163330
31cAMP signaling pathway_Homo sapiens_hsa040241.16989304
32Nitrogen metabolism_Homo sapiens_hsa009101.16285589
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14623814
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11840321
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10219873
36Type II diabetes mellitus_Homo sapiens_hsa049301.03874159
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03516523
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.01335618
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00521094
40Circadian rhythm_Homo sapiens_hsa047101.00467705
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99719105
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99284262
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96557884
44Collecting duct acid secretion_Homo sapiens_hsa049660.95122453
45Pancreatic secretion_Homo sapiens_hsa049720.94022850
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.93347518
47Propanoate metabolism_Homo sapiens_hsa006400.91734733
48Long-term depression_Homo sapiens_hsa047300.89284686
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89093753
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89045418
51Bile secretion_Homo sapiens_hsa049760.88783114
52Glucagon signaling pathway_Homo sapiens_hsa049220.87570018
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87209964
54VEGF signaling pathway_Homo sapiens_hsa043700.87201698
55Cocaine addiction_Homo sapiens_hsa050300.86764145
56Fatty acid degradation_Homo sapiens_hsa000710.83550070
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81079385
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80180428
59Ovarian steroidogenesis_Homo sapiens_hsa049130.78358441
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.76309024
61Vibrio cholerae infection_Homo sapiens_hsa051100.76233270
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75086982
63Oocyte meiosis_Homo sapiens_hsa041140.74740278
64Arginine and proline metabolism_Homo sapiens_hsa003300.73043751
65Fatty acid biosynthesis_Homo sapiens_hsa000610.67963921
66African trypanosomiasis_Homo sapiens_hsa051430.67350844
67Thyroid hormone synthesis_Homo sapiens_hsa049180.65949008
68Melanogenesis_Homo sapiens_hsa049160.65437423
69AMPK signaling pathway_Homo sapiens_hsa041520.64132770
70Gap junction_Homo sapiens_hsa045400.61593561
71* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61389955
72Phenylalanine metabolism_Homo sapiens_hsa003600.60522182
73Tryptophan metabolism_Homo sapiens_hsa003800.59706738
74Starch and sucrose metabolism_Homo sapiens_hsa005000.58512942
75PPAR signaling pathway_Homo sapiens_hsa033200.57226602
76Fatty acid metabolism_Homo sapiens_hsa012120.57055513
77MAPK signaling pathway_Homo sapiens_hsa040100.54072326
78ErbB signaling pathway_Homo sapiens_hsa040120.52519247
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52106985
80Tight junction_Homo sapiens_hsa045300.52052267
81Prion diseases_Homo sapiens_hsa050200.51961497
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51789285
83Focal adhesion_Homo sapiens_hsa045100.51229231
84Inositol phosphate metabolism_Homo sapiens_hsa005620.51001782
85Choline metabolism in cancer_Homo sapiens_hsa052310.50443995
86Estrogen signaling pathway_Homo sapiens_hsa049150.49687497
87Endocytosis_Homo sapiens_hsa041440.49517036
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48180983
89Phototransduction_Homo sapiens_hsa047440.47741082
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46543223
91Protein digestion and absorption_Homo sapiens_hsa049740.45355668
92Insulin signaling pathway_Homo sapiens_hsa049100.45326389
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.44107978
94beta-Alanine metabolism_Homo sapiens_hsa004100.43586908
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43562860
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43212671
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.42315095
98Wnt signaling pathway_Homo sapiens_hsa043100.42121371
99Glioma_Homo sapiens_hsa052140.41406726
100ECM-receptor interaction_Homo sapiens_hsa045120.40842229
101Dorso-ventral axis formation_Homo sapiens_hsa043200.40325325
102Histidine metabolism_Homo sapiens_hsa003400.38766016
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.38663040
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38344864
105mTOR signaling pathway_Homo sapiens_hsa041500.37528636
106Insulin resistance_Homo sapiens_hsa049310.37228554
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37022724
108Alzheimers disease_Homo sapiens_hsa050100.36583896
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36443598
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.35769106
111Carbon metabolism_Homo sapiens_hsa012000.35337035
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33783882
113Butanoate metabolism_Homo sapiens_hsa006500.33638777
114ABC transporters_Homo sapiens_hsa020100.33594222
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32819380
116Ras signaling pathway_Homo sapiens_hsa040140.32553860
117Fructose and mannose metabolism_Homo sapiens_hsa000510.32456518
118Pyruvate metabolism_Homo sapiens_hsa006200.32403111
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31360755
120Rap1 signaling pathway_Homo sapiens_hsa040150.30042815
121Hippo signaling pathway_Homo sapiens_hsa043900.29903918
122Axon guidance_Homo sapiens_hsa043600.28696640
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28585539
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27542267
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27348246
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25767536

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