EYA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1metanephric mesenchyme development (GO:0072075)7.04390364
2kidney mesenchyme development (GO:0072074)6.39851578
3opsonization (GO:0008228)5.63823155
4behavioral response to nicotine (GO:0035095)5.26931860
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.17757998
6mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.03288185
7* regulation of cardioblast proliferation (GO:0003264)4.72901644
8* regulation of secondary heart field cardioblast proliferation (GO:0003266)4.72901644
9parturition (GO:0007567)4.71071696
10myoblast migration (GO:0051451)4.64562403
11* middle ear morphogenesis (GO:0042474)4.56219319
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39549974
13cell differentiation involved in metanephros development (GO:0072202)4.39137951
14generation of neurons (GO:0048699)4.31292081
15cranial nerve morphogenesis (GO:0021602)4.22920049
16mesenchymal cell differentiation involved in renal system development (GO:2001012)4.09760313
17mesenchymal cell differentiation involved in kidney development (GO:0072161)4.09760313
18cilium or flagellum-dependent cell motility (GO:0001539)4.04455080
19auditory receptor cell differentiation (GO:0042491)4.04000931
20mesenchymal to epithelial transition (GO:0060231)3.96127513
21regulation of DNA endoreduplication (GO:0032875)3.94058080
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92271150
23negative regulation of response to food (GO:0032096)3.91799907
24negative regulation of appetite (GO:0032099)3.91799907
25mesenchyme morphogenesis (GO:0072132)3.91163901
26otic vesicle formation (GO:0030916)3.90872301
27nephron tubule formation (GO:0072079)3.81457824
28axoneme assembly (GO:0035082)3.80509531
29piRNA metabolic process (GO:0034587)3.71358244
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.68316636
31NADH dehydrogenase complex assembly (GO:0010257)3.68316636
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68316636
33epithelial cilium movement (GO:0003351)3.61157210
34DNA deamination (GO:0045006)3.60672438
35cilium movement (GO:0003341)3.58973042
36forebrain morphogenesis (GO:0048853)3.58321295
37embryonic cranial skeleton morphogenesis (GO:0048701)3.57567334
38* outer ear morphogenesis (GO:0042473)3.56731154
39regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.56135129
40interkinetic nuclear migration (GO:0022027)3.54489549
41sulfation (GO:0051923)3.51491010
42regulation of non-canonical Wnt signaling pathway (GO:2000050)3.51423335
43energy homeostasis (GO:0097009)3.51326470
44regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.48559953
45positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.47448767
46paraxial mesoderm development (GO:0048339)3.47255061
47protein polyglutamylation (GO:0018095)3.43611501
48somite development (GO:0061053)3.43023543
49protein complex biogenesis (GO:0070271)3.42006482
50indolalkylamine metabolic process (GO:0006586)3.41139535
51negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.41068197
52axonemal dynein complex assembly (GO:0070286)3.40441861
53positive regulation of catecholamine secretion (GO:0033605)3.36736436
54G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.30034207
55regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.28177176
56water-soluble vitamin biosynthetic process (GO:0042364)3.27547713
57negative regulation of transcription regulatory region DNA binding (GO:2000678)3.27444517
58positive regulation of embryonic development (GO:0040019)3.26732719
59mechanoreceptor differentiation (GO:0042490)3.24893920
60mesenchymal cell differentiation (GO:0048762)3.23995566
61regulation of mesoderm development (GO:2000380)3.23454187
62definitive hemopoiesis (GO:0060216)3.22933750
63mesonephros development (GO:0001823)3.22686692
64DNA methylation involved in gamete generation (GO:0043046)3.22058297
65negative regulation of dendrite development (GO:2000171)3.21899166
66endocardial cushion morphogenesis (GO:0003203)3.21710398
67organ induction (GO:0001759)3.20424794
68muscle cell migration (GO:0014812)3.19827011
69dopaminergic neuron differentiation (GO:0071542)3.19687936
70positive regulation of mesonephros development (GO:0061213)3.19483541
71ganglion development (GO:0061548)3.17646690
72mitochondrial respiratory chain complex assembly (GO:0033108)3.14001245
73facial nerve structural organization (GO:0021612)3.11537899
74xenobiotic catabolic process (GO:0042178)3.11495036
75intraciliary transport (GO:0042073)3.11385823
76* aorta morphogenesis (GO:0035909)3.10364676
77membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.09648492
78positive regulation of cAMP-mediated signaling (GO:0043950)3.07241390
79regulation of mesonephros development (GO:0061217)3.06998977
80lateral sprouting from an epithelium (GO:0060601)3.06367874
81negative regulation of kidney development (GO:0090185)3.05553017
82mesenchymal-epithelial cell signaling (GO:0060638)3.04787460
83regulation of meiosis I (GO:0060631)3.02773203
84positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.02591110
85negative regulation of systemic arterial blood pressure (GO:0003085)3.02434705
86ovulation cycle (GO:0042698)3.00511204
87serotonin metabolic process (GO:0042428)3.00474587
88inner ear receptor cell differentiation (GO:0060113)3.00314828
89thyroid gland development (GO:0030878)2.99414345
90* regulation of organ formation (GO:0003156)2.98204013
91membrane repolarization during action potential (GO:0086011)2.97844147
92left/right pattern formation (GO:0060972)2.97709136
93regulation of skeletal muscle contraction (GO:0014819)2.94139071
94one-carbon compound transport (GO:0019755)2.94046356
95regulation of cell proliferation involved in kidney development (GO:1901722)2.93950955
96mitotic sister chromatid cohesion (GO:0007064)2.91454358
97* metanephros development (GO:0001656)2.91281653
98regulation of mesenchymal cell apoptotic process (GO:2001053)2.90825155
99regulation of female receptivity (GO:0045924)2.90282422
100regulation of somitogenesis (GO:0014807)2.89044152
101face development (GO:0060324)2.87907519
102sympathetic nervous system development (GO:0048485)2.87652458
103positive regulation of digestive system process (GO:0060456)2.85316147
104regulation of female gonad development (GO:2000194)2.85229020
105primary amino compound metabolic process (GO:1901160)2.83928719
106detection of light stimulus involved in sensory perception (GO:0050962)2.83131802
107detection of light stimulus involved in visual perception (GO:0050908)2.83131802
108DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.82052063
109ribosomal small subunit assembly (GO:0000028)2.81289705
110positive regulation of gastrulation (GO:2000543)2.81243770
111cellular anion homeostasis (GO:0030002)2.80715970
112embryonic digit morphogenesis (GO:0042733)2.80251593
113* cochlea morphogenesis (GO:0090103)2.79967534
114proximal/distal pattern formation (GO:0009954)2.79854454
115ureteric bud development (GO:0001657)2.79808960
116indole-containing compound metabolic process (GO:0042430)2.78619032
117tryptophan catabolic process (GO:0006569)2.78236001
118indole-containing compound catabolic process (GO:0042436)2.78236001
119indolalkylamine catabolic process (GO:0046218)2.78236001
120negative regulation of chondrocyte differentiation (GO:0032331)2.77312419
121lung morphogenesis (GO:0060425)2.77047720
122regulation of action potential (GO:0098900)2.75899042
123polyketide metabolic process (GO:0030638)2.75679207
124doxorubicin metabolic process (GO:0044598)2.75679207
125daunorubicin metabolic process (GO:0044597)2.75679207
126motile cilium assembly (GO:0044458)2.75503051
127regulation of glomerulus development (GO:0090192)2.75456295
128cell proliferation involved in kidney development (GO:0072111)2.73919669
129cell proliferation involved in metanephros development (GO:0072203)2.73899091
130lymphangiogenesis (GO:0001946)2.73406240
131* pharyngeal system development (GO:0060037)2.72762429
132seminiferous tubule development (GO:0072520)2.72477651
133negative regulation of mast cell activation (GO:0033004)2.71089859
134negative regulation of neurotransmitter secretion (GO:0046929)2.70284177
135kynurenine metabolic process (GO:0070189)2.69676715
136mesonephric tubule development (GO:0072164)2.68754459
137lung-associated mesenchyme development (GO:0060484)2.67733980
138base-excision repair, AP site formation (GO:0006285)2.66912810
139smooth muscle tissue development (GO:0048745)2.66703140
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65587586
141endosome to melanosome transport (GO:0035646)2.65229026
142endosome to pigment granule transport (GO:0043485)2.65229026
143male meiosis I (GO:0007141)2.65136595
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65092294
145cerebellar Purkinje cell layer development (GO:0021680)2.64724348
146phenol-containing compound catabolic process (GO:0019336)2.64479311
147transmission of nerve impulse (GO:0019226)2.63707791
148tooth mineralization (GO:0034505)2.63683703
149* regulation of heart morphogenesis (GO:2000826)2.63330396
150epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.63266799
151response to nitrosative stress (GO:0051409)2.63048662
152flavonoid metabolic process (GO:0009812)2.62669668
153mesonephric epithelium development (GO:0072163)2.62198555
154cell differentiation involved in kidney development (GO:0061005)2.61607127
155ear development (GO:0043583)2.61494087
156cornea development in camera-type eye (GO:0061303)2.61218391
157* branching involved in ureteric bud morphogenesis (GO:0001658)2.61165490
158* regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.61157708
159somatic stem cell division (GO:0048103)2.61154152
160gamma-aminobutyric acid transport (GO:0015812)2.61019814
161negative regulation of osteoblast proliferation (GO:0033689)2.60892412
162DNA damage induced protein phosphorylation (GO:0006975)2.59334630
163regulation of appetite (GO:0032098)2.59164167
164developmental induction (GO:0031128)2.58883177
165response to inactivity (GO:0014854)2.57871644
166regulation of posttranscriptional gene silencing (GO:0060147)2.57822867
167regulation of gene silencing by miRNA (GO:0060964)2.57822867
168regulation of gene silencing by RNA (GO:0060966)2.57822867
169notochord development (GO:0030903)2.57344475
170RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57324072
171tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57324072
172negative regulation of fatty acid transport (GO:2000192)2.56743566
173positive regulation of meiosis (GO:0045836)2.56405881
174hair cell differentiation (GO:0035315)2.56196271
175regulation of sequestering of triglyceride (GO:0010889)2.55943865
176regulation of kidney development (GO:0090183)2.55336610
177DNA damage response, signal transduction resulting in transcription (GO:0042772)2.55200854
178cellular response to ATP (GO:0071318)2.55053249
179negative regulation of neurotransmitter transport (GO:0051589)2.54948637
180regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53038955
181forelimb morphogenesis (GO:0035136)2.53032003
182embryonic skeletal joint morphogenesis (GO:0060272)2.52627710
183cell proliferation in forebrain (GO:0021846)2.52559353
184regulation of morphogenesis of a branching structure (GO:0060688)2.52243869
185negative regulation of cardiac muscle tissue development (GO:0055026)2.52064401
186response to pheromone (GO:0019236)2.51979808
187regulation of cilium movement (GO:0003352)2.48831419
188regulation of collateral sprouting (GO:0048670)2.47166929
189pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.46590320
190regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.46442863
191positive regulation of synapse maturation (GO:0090129)2.46397527
192regulation of membrane repolarization (GO:0060306)2.46062878
193positive regulation of potassium ion transmembrane transport (GO:1901381)2.45753996
194vitamin A metabolic process (GO:0006776)2.45622817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21261603
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.85970016
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.33260821
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.84056919
5VDR_22108803_ChIP-Seq_LS180_Human3.10494893
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.96719343
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.95966150
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.74929751
9EWS_26573619_Chip-Seq_HEK293_Human2.50802464
10ZNF274_21170338_ChIP-Seq_K562_Hela2.49965398
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.48918462
12IRF1_19129219_ChIP-ChIP_H3396_Human2.42783609
13IGF1R_20145208_ChIP-Seq_DFB_Human2.42256850
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.41425161
15* FUS_26573619_Chip-Seq_HEK293_Human2.37812578
16GBX2_23144817_ChIP-Seq_PC3_Human2.36979174
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.26672013
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24427114
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.24009971
20SCL_19346495_ChIP-Seq_HPC-7_Human2.22079338
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.10577365
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02398157
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98111454
24* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97501132
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94682086
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.94682086
27E2F7_22180533_ChIP-Seq_HELA_Human1.92254813
28TP53_16413492_ChIP-PET_HCT116_Human1.90117978
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85695140
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81433338
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79597946
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77163059
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75283013
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.74102531
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67568057
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64721219
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62301866
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61217848
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60073079
40* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.58405967
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53345180
42TP53_18474530_ChIP-ChIP_U2OS_Human1.52828221
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52333487
44ER_23166858_ChIP-Seq_MCF-7_Human1.51855035
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51822987
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51801824
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.51687038
48BRD4_25478319_ChIP-Seq_HGPS_Human1.50109557
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49015315
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.48516167
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46789661
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44049096
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43694095
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42979602
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.42627032
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40536704
57* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40476112
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37489124
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.36220826
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.36096148
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34639632
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.33370171
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33116794
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33113029
65STAT3_23295773_ChIP-Seq_U87_Human1.32597028
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31961523
67* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29254827
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27904827
69* CBP_20019798_ChIP-Seq_JUKART_Human1.27586153
70* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27586153
71LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27052797
72* FLI1_27457419_Chip-Seq_LIVER_Mouse1.25976046
73* TCF4_23295773_ChIP-Seq_U87_Human1.25857533
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.25251881
75* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24899240
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23663296
77TP53_22573176_ChIP-Seq_HFKS_Human1.23169040
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.22856649
79AHR_22903824_ChIP-Seq_MCF-7_Human1.21345175
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20831222
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.20770362
82AR_21909140_ChIP-Seq_LNCAP_Human1.20392405
83CJUN_26792858_Chip-Seq_BT549_Human1.20314603
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20310860
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19520806
86REST_21632747_ChIP-Seq_MESCs_Mouse1.18892052
87* P300_19829295_ChIP-Seq_ESCs_Human1.18518264
88* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18292925
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16781136
90RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16765358
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16765358
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.16508377
93NCOR_22424771_ChIP-Seq_293T_Human1.16479764
94TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16383409
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.16062341
96* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15478519
97RUNX2_22187159_ChIP-Seq_PCA_Human1.15449367
98* TAL1_26923725_Chip-Seq_HPCs_Mouse1.14912549
99VDR_24787735_ChIP-Seq_THP-1_Human1.12974875
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.12584954
101* ISL1_27105846_Chip-Seq_CPCs_Mouse1.12581001
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12538039
103* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12377119
104* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12079121
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10778589
106MYC_18940864_ChIP-ChIP_HL60_Human1.10664192
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10252564
108* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10045958
109EZH2_27304074_Chip-Seq_ESCs_Mouse1.09963531
110* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09283686
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08916747
112TAF15_26573619_Chip-Seq_HEK293_Human1.08634620
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08265127
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.08265127
115* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07818861
116* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07818008
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07686897
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07661141
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07459352
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07147441
121* AR_25329375_ChIP-Seq_VCAP_Human1.06558964
122SOX2_19829295_ChIP-Seq_ESCs_Human1.05224385
123NANOG_19829295_ChIP-Seq_ESCs_Human1.05224385
124* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04448672
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.04153432
126* EZH2_27294783_Chip-Seq_NPCs_Mouse1.03922471
127SOX2_16153702_ChIP-ChIP_HESCs_Human1.02686826
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02398961
129RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01501745
130* SMAD4_21741376_ChIP-Seq_EPCs_Human1.01274016
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00236908
132PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00178277
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99892186
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.99877662
135RNF2_27304074_Chip-Seq_NSC_Mouse0.99709007
136* NFE2_27457419_Chip-Seq_LIVER_Mouse0.99605798
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99498966
138* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99326213
139* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99101455
140* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98945086
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98797473
142BCAT_22108803_ChIP-Seq_LS180_Human0.98544322
143TCF4_22108803_ChIP-Seq_LS180_Human0.98049561
144AR_21572438_ChIP-Seq_LNCaP_Human0.97884217
145* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97363990
146* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97363990
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97269832
148SMAD4_21799915_ChIP-Seq_A2780_Human0.97267469
149KDM2B_26808549_Chip-Seq_REH_Human0.96892722
150* GF1B_26923725_Chip-Seq_HPCs_Mouse0.96598709
151CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95709069
152FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95670151
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95623644
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94712335
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.94680518
156* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93936787
157RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93590994
158KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92461921
159KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92461921
160KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92461921
161SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92261886
162* RING1B_27294783_Chip-Seq_NPCs_Mouse0.91828010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.23801180
2MP0008789_abnormal_olfactory_epithelium3.99084339
3MP0000566_synostosis3.26867776
4MP0005394_taste/olfaction_phenotype3.21828234
5MP0005499_abnormal_olfactory_system3.21828234
6MP0003878_abnormal_ear_physiology3.15458413
7MP0005377_hearing/vestibular/ear_phenot3.15458413
8MP0003646_muscle_fatigue3.09512517
9MP0006292_abnormal_olfactory_placode2.87188471
10* MP0000049_abnormal_middle_ear2.77010209
11MP0008877_abnormal_DNA_methylation2.63716013
12MP0002938_white_spotting2.57685845
13MP0002837_dystrophic_cardiac_calcinosis2.51257215
14MP0003941_abnormal_skin_development2.43262739
15MP0002877_abnormal_melanocyte_morpholog2.41950038
16MP0000372_irregular_coat_pigmentation2.35576228
17MP0001346_abnormal_lacrimal_gland2.34801429
18MP0005389_reproductive_system_phenotype2.23993402
19* MP0009250_abnormal_appendicular_skeleto2.23294130
20MP0002102_abnormal_ear_morphology2.21518224
21* MP0003942_abnormal_urinary_system2.18450907
22MP0002638_abnormal_pupillary_reflex2.16268311
23MP0005551_abnormal_eye_electrophysiolog2.09156311
24MP0001485_abnormal_pinna_reflex2.04598152
25MP0004145_abnormal_muscle_electrophysio1.99439368
26* MP0002233_abnormal_nose_morphology1.97649037
27MP0001849_ear_inflammation1.93628396
28MP0003937_abnormal_limbs/digits/tail_de1.91062473
29MP0000762_abnormal_tongue_morphology1.84950668
30MP0002653_abnormal_ependyma_morphology1.83758353
31* MP0000678_abnormal_parathyroid_gland1.83402970
32MP0005670_abnormal_white_adipose1.80294829
33* MP0000534_abnormal_ureter_morphology1.75634994
34MP0002822_catalepsy1.74780421
35MP0005171_absent_coat_pigmentation1.73073001
36MP0008995_early_reproductive_senescence1.70927587
37MP0009379_abnormal_foot_pigmentation1.68372701
38MP0000015_abnormal_ear_pigmentation1.67592228
39MP0003879_abnormal_hair_cell1.67258202
40* MP0002177_abnormal_outer_ear1.64428849
41MP0002735_abnormal_chemical_nociception1.63341462
42MP0000569_abnormal_digit_pigmentation1.63246135
43MP0002095_abnormal_skin_pigmentation1.61211874
44MP0001968_abnormal_touch/_nociception1.60210831
45MP0003011_delayed_dark_adaptation1.59500871
46* MP0002249_abnormal_larynx_morphology1.58852505
47MP0009745_abnormal_behavioral_response1.55858498
48* MP0003755_abnormal_palate_morphology1.54737866
49MP0002272_abnormal_nervous_system1.53628851
50MP0005645_abnormal_hypothalamus_physiol1.53066874
51MP0008007_abnormal_cellular_replicative1.50358963
52MP0001270_distended_abdomen1.48569263
53MP0005253_abnormal_eye_physiology1.47245681
54MP0006276_abnormal_autonomic_nervous1.45875000
55MP0002138_abnormal_hepatobiliary_system1.45690132
56MP0005248_abnormal_Harderian_gland1.45078624
57MP0005646_abnormal_pituitary_gland1.44310385
58MP0004215_abnormal_myocardial_fiber1.41522414
59MP0005174_abnormal_tail_pigmentation1.40255664
60MP0000733_abnormal_muscle_development1.39493159
61MP0002254_reproductive_system_inflammat1.39021830
62MP0000613_abnormal_salivary_gland1.38987543
63MP0000428_abnormal_craniofacial_morphol1.36662677
64MP0001293_anophthalmia1.36419368
65MP0001486_abnormal_startle_reflex1.35442419
66MP0006072_abnormal_retinal_apoptosis1.35088287
67MP0004142_abnormal_muscle_tone1.34178742
68* MP0000026_abnormal_inner_ear1.32514646
69MP0009278_abnormal_bone_marrow1.31476088
70MP0002876_abnormal_thyroid_physiology1.28742940
71MP0004134_abnormal_chest_morphology1.28652217
72MP0003385_abnormal_body_wall1.28530100
73MP0002396_abnormal_hematopoietic_system1.28343635
74MP0004808_abnormal_hematopoietic_stem1.26524414
75MP0008872_abnormal_physiological_respon1.25961723
76* MP0000631_abnormal_neuroendocrine_gland1.25942098
77* MP0003938_abnormal_ear_development1.25042935
78MP0002751_abnormal_autonomic_nervous1.25013284
79* MP0002116_abnormal_craniofacial_bone1.23040881
80MP0001440_abnormal_grooming_behavior1.22858723
81MP0002009_preneoplasia1.22155789
82MP0003718_maternal_effect1.22009416
83MP0004130_abnormal_muscle_cell1.21292052
84* MP0003935_abnormal_craniofacial_develop1.21081609
85MP0005508_abnormal_skeleton_morphology1.20403222
86MP0002184_abnormal_innervation1.15895605
87* MP0001963_abnormal_hearing_physiology1.15818737
88MP0004782_abnormal_surfactant_physiolog1.15118693
89MP0002277_abnormal_respiratory_mucosa1.15019779
90MP0008057_abnormal_DNA_replication1.15007960
91MP0001984_abnormal_olfaction1.14312559
92MP0000371_diluted_coat_color1.14103705
93MP0005410_abnormal_fertilization1.13551130
94MP0005195_abnormal_posterior_eye1.12923612
95MP0003183_abnormal_peptide_metabolism1.12731051
96MP0002109_abnormal_limb_morphology1.12226503
97MP0002075_abnormal_coat/hair_pigmentati1.11881071
98MP0005503_abnormal_tendon_morphology1.10991899
99MP0002098_abnormal_vibrissa_morphology1.10054934
100* MP0002932_abnormal_joint_morphology1.09232418
101MP0004264_abnormal_extraembryonic_tissu1.08652459
102MP0002234_abnormal_pharynx_morphology1.08606374
103MP0001299_abnormal_eye_distance/1.08249366
104MP0003119_abnormal_digestive_system1.08195122
105MP0002736_abnormal_nociception_after1.07373730
106MP0010386_abnormal_urinary_bladder1.07326475
107MP0001986_abnormal_taste_sensitivity1.07208774
108MP0001879_abnormal_lymphatic_vessel1.06665533
109MP0001919_abnormal_reproductive_system1.06152620
110MP0009053_abnormal_anal_canal1.06060979
111MP0002163_abnormal_gland_morphology1.04940221
112MP0002733_abnormal_thermal_nociception1.04258556
113MP0009046_muscle_twitch1.00804394
114MP0003880_abnormal_central_pattern1.00484386
115MP0005187_abnormal_penis_morphology1.00140864
116MP0010368_abnormal_lymphatic_system0.99391309
117MP0008875_abnormal_xenobiotic_pharmacok0.99020389
118MP0002092_abnormal_eye_morphology0.98744800
119MP0001970_abnormal_pain_threshold0.97066759
120MP0002734_abnormal_mechanical_nocicepti0.97033950
121MP0005408_hypopigmentation0.95899487
122MP0002928_abnormal_bile_duct0.95516298
123* MP0002752_abnormal_somatic_nervous0.95143902
124MP0000013_abnormal_adipose_tissue0.94664389
125MP0002210_abnormal_sex_determination0.93854556
126MP0005197_abnormal_uvea_morphology0.92720302
127MP0002127_abnormal_cardiovascular_syste0.92192529
128MP0001324_abnormal_eye_pigmentation0.91978553
129MP0002063_abnormal_learning/memory/cond0.91897421
130MP0003315_abnormal_perineum_morphology0.91580960
131MP0002064_seizures0.91131528
132MP0001929_abnormal_gametogenesis0.89739464
133MP0003279_aneurysm0.89402388
134* MP0000681_abnormal_thyroid_gland0.88407527
135* MP0000163_abnormal_cartilage_morphology0.87688066
136MP0003635_abnormal_synaptic_transmissio0.87472218
137MP0003567_abnormal_fetal_cardiomyocyte0.86828537
138MP0001186_pigmentation_phenotype0.86708289
139MP0001145_abnormal_male_reproductive0.86069841
140MP0008775_abnormal_heart_ventricle0.86055791
141MP0000653_abnormal_sex_gland0.86030874
142MP0008961_abnormal_basal_metabolism0.85981670
143MP0003121_genomic_imprinting0.85909957
144MP0000230_abnormal_systemic_arterial0.85779686
145MP0005075_abnormal_melanosome_morpholog0.85773414
146MP0002572_abnormal_emotion/affect_behav0.85518182
147MP0001177_atelectasis0.85312889
148MP0003698_abnormal_male_reproductive0.85051879
149MP0003787_abnormal_imprinting0.85039155
150MP0004885_abnormal_endolymph0.84842599
151MP0002557_abnormal_social/conspecific_i0.84506197
152* MP0000432_abnormal_head_morphology0.84086823
153MP0003283_abnormal_digestive_organ0.83182300
154MP0004085_abnormal_heartbeat0.81992605
155MP0003943_abnormal_hepatobiliary_system0.81860231
156MP0005397_hematopoietic_system_phenotyp0.81438722
157MP0001545_abnormal_hematopoietic_system0.81438722
158MP0001905_abnormal_dopamine_level0.80338131
159MP0010094_abnormal_chromosome_stability0.78550351
160* MP0002114_abnormal_axial_skeleton0.78007125
161MP0005360_urolithiasis0.75685108
162MP0002115_abnormal_skeleton_extremities0.73860737
163MP0002111_abnormal_tail_morphology0.73416184
164MP0001286_abnormal_eye_development0.72936826
165MP0004133_heterotaxia0.71445334
166MP0002697_abnormal_eye_size0.70325983
167MP0001188_hyperpigmentation0.69421619
168MP0001119_abnormal_female_reproductive0.68931609
169MP0002132_abnormal_respiratory_system0.68745701
170MP0002160_abnormal_reproductive_system0.67153372
171MP0000383_abnormal_hair_follicle0.66960770
172MP0002113_abnormal_skeleton_development0.65340902

Predicted human phenotypes

RankGene SetZ-score
1* Lip pit (HP:0100267)4.43411929
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.05575216
3Dynein arm defect of respiratory motile cilia (HP:0012255)3.99179709
4Absent/shortened dynein arms (HP:0200106)3.99179709
5Abolished electroretinogram (ERG) (HP:0000550)3.51152987
6Short 1st metacarpal (HP:0010034)3.48756473
7Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.48756473
8Abnormal ciliary motility (HP:0012262)3.41171424
9Genetic anticipation (HP:0003743)3.33460412
10Abnormal respiratory epithelium morphology (HP:0012253)3.33020644
11Abnormal respiratory motile cilium morphology (HP:0005938)3.33020644
12Nephronophthisis (HP:0000090)3.21624393
13Abnormal respiratory motile cilium physiology (HP:0012261)3.21155854
14Decreased circulating renin level (HP:0003351)3.15335663
15Congenital stationary night blindness (HP:0007642)3.13342900
16Pendular nystagmus (HP:0012043)3.12039959
17Hypothermia (HP:0002045)3.10330708
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.06468352
19True hermaphroditism (HP:0010459)3.05871918
20Abnormality of the 1st metacarpal (HP:0010009)3.04051585
21Spinal cord lesions (HP:0100561)3.01778508
22Syringomyelia (HP:0003396)3.01778508
23Abnormal rod and cone electroretinograms (HP:0008323)3.01609822
24Short 4th metacarpal (HP:0010044)2.96067746
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96067746
26Abnormality of the phalanges of the 2nd finger (HP:0009541)2.90499900
27Decreased central vision (HP:0007663)2.83458119
28Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.81445942
29Chronic hepatic failure (HP:0100626)2.77249242
30Tubulointerstitial nephritis (HP:0001970)2.76832125
31Papillary thyroid carcinoma (HP:0002895)2.76473418
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66472672
33Keratoconus (HP:0000563)2.66193613
34Increased corneal curvature (HP:0100692)2.66193613
35Progressive cerebellar ataxia (HP:0002073)2.64547770
36Pancreatic fibrosis (HP:0100732)2.62826842
37Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.62114988
38Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.53855173
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.53698658
40Short phalanx of the thumb (HP:0009660)2.53479159
41Rhinitis (HP:0012384)2.52601519
42Methylmalonic acidemia (HP:0002912)2.48361026
43Asplenia (HP:0001746)2.47339332
44Short tibia (HP:0005736)2.47306189
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.47178131
46Duplicated collecting system (HP:0000081)2.46896754
47* Abnormality of the renal collecting system (HP:0004742)2.46896754
48* Renal dysplasia (HP:0000110)2.45525731
49Long clavicles (HP:0000890)2.44937348
50Male pseudohermaphroditism (HP:0000037)2.44432917
51Medial flaring of the eyebrow (HP:0010747)2.41282693
52Cystic liver disease (HP:0006706)2.40898346
53Abnormality of the phalanges of the 5th finger (HP:0004213)2.39256554
54Attenuation of retinal blood vessels (HP:0007843)2.36634929
55Hypoplasia of the fovea (HP:0007750)2.34724990
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.34724990
57Abnormality of the renal cortex (HP:0011035)2.34584866
58Short middle phalanx of the 5th finger (HP:0004220)2.33071899
59Abnormality of the proximal phalanges of the hand (HP:0009834)2.31061627
60Abnormality of cells of the erythroid lineage (HP:0012130)2.29157901
61Acute necrotizing encephalopathy (HP:0006965)2.27349406
62Bony spicule pigmentary retinopathy (HP:0007737)2.27006634
63Popliteal pterygium (HP:0009756)2.19882935
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.19182699
65Natal tooth (HP:0000695)2.16159519
66Hyperglycinemia (HP:0002154)2.16036099
67Volvulus (HP:0002580)2.15507135
68Synostosis of carpal bones (HP:0005048)2.15497797
69Hypoplastic labia majora (HP:0000059)2.15345833
70Short hallux (HP:0010109)2.14767945
71Mesomelia (HP:0003027)2.10517762
72Absent thumb (HP:0009777)2.10067249
73Optic disc pallor (HP:0000543)2.09883715
74Abnormal number of erythroid precursors (HP:0012131)2.09251266
75Abnormality of the renal medulla (HP:0100957)2.08922024
76Urethral obstruction (HP:0000796)2.07600594
77Mitochondrial inheritance (HP:0001427)2.07111047
78Abnormality of midbrain morphology (HP:0002418)2.07053228
79Molar tooth sign on MRI (HP:0002419)2.07053228
80Alacrima (HP:0000522)2.05298108
81Selective tooth agenesis (HP:0001592)2.04305266
82Congenital sensorineural hearing impairment (HP:0008527)2.03239352
83Aplasia/Hypoplasia of the hallux (HP:0008362)2.02937581
84Increased nuchal translucency (HP:0010880)2.02419087
85Abnormality of the nasal septum (HP:0000419)2.01185925
86Congenital hepatic fibrosis (HP:0002612)2.00791020
87Tubular atrophy (HP:0000092)2.00613319
88Abnormality of the labia majora (HP:0012881)2.00365919
89Dyskinesia (HP:0100660)1.99788801
90Methylmalonic aciduria (HP:0012120)1.97580246
91Chorioretinal atrophy (HP:0000533)1.97517806
92Optic nerve coloboma (HP:0000588)1.96597198
93Chronic bronchitis (HP:0004469)1.96454895
94Bifid scrotum (HP:0000048)1.96194044
95Renal duplication (HP:0000075)1.95964265
96Small hand (HP:0200055)1.95886331
97Cutaneous finger syndactyly (HP:0010554)1.95659152
98Abnormality of DNA repair (HP:0003254)1.95622594
99Aplasia/Hypoplasia of the macula (HP:0008059)1.95547443
100Congenital, generalized hypertrichosis (HP:0004540)1.94661148
101Progressive macrocephaly (HP:0004481)1.94190639
102Abnormal mitochondria in muscle tissue (HP:0008316)1.93838460
103Postaxial foot polydactyly (HP:0001830)1.93447287
104Aplasia involving bones of the upper limbs (HP:0009823)1.93385166
105Aplasia of the phalanges of the hand (HP:0009802)1.93385166
106Aplasia involving bones of the extremities (HP:0009825)1.93385166
107Tarsal synostosis (HP:0008368)1.93299846
108* Abnormality of the nasolacrimal system (HP:0000614)1.91879633
109Symphalangism affecting the phalanges of the hand (HP:0009773)1.91623970
110Bifid tongue (HP:0010297)1.91484013
111Cutaneous syndactyly (HP:0012725)1.90784781
112Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.90427714
113Abnormality of the 2nd finger (HP:0004100)1.90241129
114* Mixed hearing impairment (HP:0000410)1.90213752
115Sclerocornea (HP:0000647)1.89782368
116Synostosis involving bones of the lower limbs (HP:0009138)1.89594188
117Synostosis involving bones of the feet (HP:0009140)1.89594188
118Stomach cancer (HP:0012126)1.89562923
119Osteomalacia (HP:0002749)1.89351722
120Neonatal hypoglycemia (HP:0001998)1.88875238
121Hypoplasia of the uterus (HP:0000013)1.86431932
122Abnormality of the fovea (HP:0000493)1.85717988
123Bell-shaped thorax (HP:0001591)1.85088250
124Fibular hypoplasia (HP:0003038)1.83711449
125Synostosis involving the elbow (HP:0003938)1.83361325
126Humeroradial synostosis (HP:0003041)1.83361325
127Increased CSF lactate (HP:0002490)1.83306840
128Congenital primary aphakia (HP:0007707)1.81957057
129Broad toe (HP:0001837)1.81702105
130Gait imbalance (HP:0002141)1.81392614
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81282105
132Constricted visual fields (HP:0001133)1.81199980
133Acute encephalopathy (HP:0006846)1.81131462
134Abnormality of the 4th metacarpal (HP:0010012)1.80798932
135Acute myeloid leukemia (HP:0004808)1.80218945
136Ectopic kidney (HP:0000086)1.79997700
137Gaze-evoked nystagmus (HP:0000640)1.79329068
138Carpal bone hypoplasia (HP:0001498)1.78158419
139Tachypnea (HP:0002789)1.76791540
140Pallor (HP:0000980)1.76668772
141* Preauricular pit (HP:0004467)1.76264433
142* Periauricular skin pits (HP:0100277)1.76264433
143Abnormality of incisor morphology (HP:0011063)1.75425241
144Short middle phalanx of finger (HP:0005819)1.74802928
145Vaginal atresia (HP:0000148)1.74567873
146Adactyly (HP:0009776)1.73604352
147Spondylolisthesis (HP:0003302)1.73469185
148Absent frontal sinuses (HP:0002688)1.73312778
149Abnormality of the pubic bones (HP:0003172)1.72248798
150Polydipsia (HP:0001959)1.72048864
151Abnormal drinking behavior (HP:0030082)1.72048864
152Renal hypoplasia (HP:0000089)1.72014325
153Short femoral neck (HP:0100864)1.71566864
154Aplasia/Hypoplasia affecting the retina (HP:0008061)1.71061580
155Occipital encephalocele (HP:0002085)1.70635787
156Nephrogenic diabetes insipidus (HP:0009806)1.69966711
157Epiphyseal dysplasia (HP:0002656)1.69481012
158Absent eyebrow (HP:0002223)1.68515346
159Carpal synostosis (HP:0009702)1.68432381
160Partial duplication of the phalanx of hand (HP:0009999)1.67896694
161Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67686067
162Muscle fiber atrophy (HP:0100295)1.67638470
163Type 2 muscle fiber atrophy (HP:0003554)1.66454641
164Pancreatic cysts (HP:0001737)1.66279453
165Rib fusion (HP:0000902)1.64170203
166Aplasia/Hypoplasia of the scapulae (HP:0006713)1.63033734
167Hypoplastic scapulae (HP:0000882)1.63033734
168Genital tract atresia (HP:0001827)1.60714058
169Abnormality of the parietal bone (HP:0002696)1.60594771
170Abnormality of the incisor (HP:0000676)1.60392964
171Thyroid carcinoma (HP:0002890)1.59052315
172Abnormality of the middle phalanges of the toes (HP:0010183)1.59036217
173Trigonocephaly (HP:0000243)1.58362788
174Broad face (HP:0000283)1.58195427
175Anencephaly (HP:0002323)1.56974901
176Intestinal atresia (HP:0011100)1.56932765
177Abnormal lung lobation (HP:0002101)1.56864489
178Broad hallux (HP:0010055)1.56584728
179Abnormality of the right ventricle (HP:0001707)1.56369591
180Asymmetry of the thorax (HP:0001555)1.56092954
181Partial duplication of thumb phalanx (HP:0009944)1.55506192
182Fibular aplasia (HP:0002990)1.54930305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.11846194
2DDR23.84518541
3SIK33.59315745
4GRK13.33812166
5TAOK23.23173042
6MKNK13.05941079
7MKNK22.87751413
8TNIK2.82293588
9ERBB32.54662822
10TLK12.39309460
11LATS12.27570242
12MAP2K32.23062642
13TGFBR12.15564842
14MAP4K22.09841815
15PASK2.03677258
16CDK61.96458535
17SIK11.96442578
18ZAK1.95150989
19FLT31.89967683
20TAOK31.88409810
21PINK11.85544337
22MAPK151.83074080
23CDK191.80085804
24RPS6KB21.71152337
25TIE11.69763997
26MAP3K41.67609259
27RPS6KA41.65918674
28CDK81.60642666
29TRPM71.60152192
30KIT1.58632290
31PRPF4B1.56113713
32EIF2AK31.55212023
33SIK21.48182436
34HIPK21.47436806
35WNK31.45391745
36MATK1.42317457
37CSNK1A1L1.40999208
38STK38L1.37064887
39EPHA31.34960156
40ATR1.32313863
41TXK1.31749682
42YES11.30467145
43MAP3K31.30406904
44ACVR1B1.20705209
45DYRK21.19275059
46MARK31.18676274
47CDK121.13194766
48MAP2K71.10666627
49OBSCN1.09417370
50CHUK1.07585434
51SGK21.07465207
52STK31.07308694
53ADRBK21.06385928
54PDGFRA1.05155797
55CDK31.02872202
56OXSR11.02605840
57STK161.02180346
58STK391.01203358
59PRKD20.98243222
60VRK10.97791221
61CDC70.97151343
62WNK40.96338858
63KDR0.94322762
64NUAK10.93708961
65SGK4940.93679490
66SGK2230.93679490
67PKN10.92402667
68MUSK0.91931537
69AURKA0.91148789
70PRKCE0.90708972
71TEC0.88652791
72CLK10.88553180
73BTK0.85931364
74MAPKAPK50.84246763
75EEF2K0.84020691
76DYRK30.78159599
77MAP2K60.77439099
78PRKCH0.77426995
79BRSK20.77358772
80RPS6KA20.75874937
81PRKACA0.72875695
82CSNK1G10.72811618
83DAPK20.71867800
84NME10.71209455
85NTRK20.69690628
86PLK20.69579357
87MAP3K70.69558563
88NLK0.64845160
89PLK40.64680560
90CDK70.64346326
91GRK70.64335317
92NEK20.63747540
93IRAK40.63513058
94PRKCG0.63082054
95NEK60.63026462
96NTRK30.62923734
97FGFR30.62631225
98PLK10.62503711
99TGFBR20.62471780
100MAPK130.58940612
101CDK90.58809712
102ERBB20.58055903
103BMPR1B0.57819340
104SGK10.55512971
105GRK50.55153947
106CASK0.54963963
107PTK60.54349301
108DYRK1B0.53947722
109CSNK1G30.53618686
110FRK0.53170846
111ABL20.53021672
112TTN0.53011941
113CSF1R0.52998185
114MARK20.52274588
115ATM0.52150632
116CAMK40.51509057
117CHEK20.51039513
118CSNK1G20.50431615
119RPS6KA60.50407450
120SGK30.50360278
121BCR0.49532122
122WNK10.49338813
123PRKCQ0.49314309
124CAMK2A0.49038751
125PAK30.49038732
126PLK30.48940795
127PRKCA0.48479138
128INSRR0.47603124
129FGFR10.46230494
130IGF1R0.46210092
131SRPK10.46199195
132AURKB0.45106995
133TTK0.44794973
134ABL10.44456128
135PIM10.44207289
136JAK30.43773901
137DYRK1A0.42973535
138RIPK10.42444906
139IRAK10.42190818
140CSNK1A10.41875562
141TNK20.41840543
142VRK20.39702887
143EPHA40.39687416
144CAMK10.39444072
145MELK0.39047699
146MAPK40.38657166
147INSR0.38461909
148MAPKAPK30.38246467
149STK380.37744142
150PIK3CA0.37310541
151SYK0.35639526
152RPS6KC10.34624591
153RPS6KL10.34624591
154PAK40.34587588
155ADRBK10.34262810
156RPS6KA50.33471322
157MARK10.32876061
158CDK40.32850131
159CAMK1G0.32513085
160MAPK140.32463806

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.60061412
2Oxidative phosphorylation_Homo sapiens_hsa001902.59122142
3Phototransduction_Homo sapiens_hsa047442.42679124
4Linoleic acid metabolism_Homo sapiens_hsa005912.18845124
5Parkinsons disease_Homo sapiens_hsa050122.10964460
6Retinol metabolism_Homo sapiens_hsa008302.09841788
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07624975
8Nicotine addiction_Homo sapiens_hsa050331.96438528
9* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.81156948
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80925353
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79669776
12Cardiac muscle contraction_Homo sapiens_hsa042601.74287226
13Huntingtons disease_Homo sapiens_hsa050161.72358275
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67598371
15DNA replication_Homo sapiens_hsa030301.67318015
16RNA polymerase_Homo sapiens_hsa030201.66997811
17Basal cell carcinoma_Homo sapiens_hsa052171.66985035
18Circadian rhythm_Homo sapiens_hsa047101.65333986
19Alzheimers disease_Homo sapiens_hsa050101.64080757
20Cell cycle_Homo sapiens_hsa041101.61468050
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57772952
22N-Glycan biosynthesis_Homo sapiens_hsa005101.56897431
23Olfactory transduction_Homo sapiens_hsa047401.55028097
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54252225
25Homologous recombination_Homo sapiens_hsa034401.49729065
26Taste transduction_Homo sapiens_hsa047421.46939398
27Mismatch repair_Homo sapiens_hsa034301.41145986
28Prostate cancer_Homo sapiens_hsa052151.39055880
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37545802
30Caffeine metabolism_Homo sapiens_hsa002321.36817539
31Non-homologous end-joining_Homo sapiens_hsa034501.34938437
32Chronic myeloid leukemia_Homo sapiens_hsa052201.34809577
33Fanconi anemia pathway_Homo sapiens_hsa034601.34193470
34TGF-beta signaling pathway_Homo sapiens_hsa043501.34053311
35Adherens junction_Homo sapiens_hsa045201.33668658
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33115015
37Thyroid cancer_Homo sapiens_hsa052161.32475177
38Notch signaling pathway_Homo sapiens_hsa043301.31941375
39Tryptophan metabolism_Homo sapiens_hsa003801.31935062
40Base excision repair_Homo sapiens_hsa034101.31593240
41Morphine addiction_Homo sapiens_hsa050321.30155719
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29584446
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29347953
44Hippo signaling pathway_Homo sapiens_hsa043901.26637361
45Basal transcription factors_Homo sapiens_hsa030221.26202348
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24404503
47Protein export_Homo sapiens_hsa030601.22387078
48RNA degradation_Homo sapiens_hsa030181.20746312
49MicroRNAs in cancer_Homo sapiens_hsa052061.20418035
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19599966
51Serotonergic synapse_Homo sapiens_hsa047261.18046917
52Chemical carcinogenesis_Homo sapiens_hsa052041.16355400
53Systemic lupus erythematosus_Homo sapiens_hsa053221.15650104
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.15366909
55Prolactin signaling pathway_Homo sapiens_hsa049171.15250649
56Circadian entrainment_Homo sapiens_hsa047131.12159816
57Ether lipid metabolism_Homo sapiens_hsa005651.10642347
58Herpes simplex infection_Homo sapiens_hsa051681.10016711
59Nitrogen metabolism_Homo sapiens_hsa009101.09733673
60Proteoglycans in cancer_Homo sapiens_hsa052051.09504162
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08510107
62Sulfur metabolism_Homo sapiens_hsa009201.07320232
63HTLV-I infection_Homo sapiens_hsa051661.06414271
64Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05775144
65Wnt signaling pathway_Homo sapiens_hsa043101.05059149
66Primary immunodeficiency_Homo sapiens_hsa053401.03899886
67Arachidonic acid metabolism_Homo sapiens_hsa005901.02654648
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01823716
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.01144925
70Cocaine addiction_Homo sapiens_hsa050301.00287852
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99647341
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.97190243
73GABAergic synapse_Homo sapiens_hsa047270.96570892
74ABC transporters_Homo sapiens_hsa020100.95464307
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.95348079
76Colorectal cancer_Homo sapiens_hsa052100.94768755
77TNF signaling pathway_Homo sapiens_hsa046680.94730470
78Sulfur relay system_Homo sapiens_hsa041220.94156833
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93280013
80Melanoma_Homo sapiens_hsa052180.93145695
81Propanoate metabolism_Homo sapiens_hsa006400.92239092
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91672702
83Peroxisome_Homo sapiens_hsa041460.91248593
84Renin secretion_Homo sapiens_hsa049240.89640392
85Glutamatergic synapse_Homo sapiens_hsa047240.88621205
86Insulin secretion_Homo sapiens_hsa049110.87923678
87Endometrial cancer_Homo sapiens_hsa052130.86388835
88Butanoate metabolism_Homo sapiens_hsa006500.85937620
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.85644814
90GnRH signaling pathway_Homo sapiens_hsa049120.85429291
91Pathways in cancer_Homo sapiens_hsa052000.85327179
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84521465
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.84286608
94Small cell lung cancer_Homo sapiens_hsa052220.84217631
95Melanogenesis_Homo sapiens_hsa049160.83043880
96Focal adhesion_Homo sapiens_hsa045100.82054246
97Non-small cell lung cancer_Homo sapiens_hsa052230.82005561
98p53 signaling pathway_Homo sapiens_hsa041150.81212343
99Hepatitis B_Homo sapiens_hsa051610.80833191
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80725677
101Calcium signaling pathway_Homo sapiens_hsa040200.80702789
102Leishmaniasis_Homo sapiens_hsa051400.79006619
103Influenza A_Homo sapiens_hsa051640.77411446
104ECM-receptor interaction_Homo sapiens_hsa045120.77324844
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77043095
106Selenocompound metabolism_Homo sapiens_hsa004500.76650456
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.76620769
108Salivary secretion_Homo sapiens_hsa049700.76012932
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75383146
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73196200
111Pancreatic cancer_Homo sapiens_hsa052120.72637636
112Vitamin digestion and absorption_Homo sapiens_hsa049770.72568757
113Ovarian steroidogenesis_Homo sapiens_hsa049130.72030379
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71532864
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71096095
116FoxO signaling pathway_Homo sapiens_hsa040680.71014971
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.70199739
118Platelet activation_Homo sapiens_hsa046110.69856141
119Galactose metabolism_Homo sapiens_hsa000520.69321052
120Regulation of autophagy_Homo sapiens_hsa041400.68515537
121beta-Alanine metabolism_Homo sapiens_hsa004100.67856665
122mRNA surveillance pathway_Homo sapiens_hsa030150.65411932
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64620400
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64457739
125Nucleotide excision repair_Homo sapiens_hsa034200.63921934
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63911173
127Measles_Homo sapiens_hsa051620.63321822
128Alcoholism_Homo sapiens_hsa050340.62882175
129Glutathione metabolism_Homo sapiens_hsa004800.62463072
130Glycerolipid metabolism_Homo sapiens_hsa005610.61476885
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61460723
132Axon guidance_Homo sapiens_hsa043600.61396011
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61206453
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60255870
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60076655
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59162449
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58823739
138Toxoplasmosis_Homo sapiens_hsa051450.58679287
139Hepatitis C_Homo sapiens_hsa051600.58537880
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.57989056
141Cholinergic synapse_Homo sapiens_hsa047250.57652692
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56368513
143Purine metabolism_Homo sapiens_hsa002300.56339008
144Pyrimidine metabolism_Homo sapiens_hsa002400.55943562
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55412146
146Starch and sucrose metabolism_Homo sapiens_hsa005000.54605965
147Spliceosome_Homo sapiens_hsa030400.53354845
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53064636
149African trypanosomiasis_Homo sapiens_hsa051430.52773647
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.52765884
151Metabolic pathways_Homo sapiens_hsa011000.52169746
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52082960
153Acute myeloid leukemia_Homo sapiens_hsa052210.51476050
154Tyrosine metabolism_Homo sapiens_hsa003500.51454485
155Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51405667
156Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50932831
157Dorso-ventral axis formation_Homo sapiens_hsa043200.50745547
158cAMP signaling pathway_Homo sapiens_hsa040240.50433065
159Rap1 signaling pathway_Homo sapiens_hsa040150.50384133
160Hedgehog signaling pathway_Homo sapiens_hsa043400.50372802
161Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50107573
162Folate biosynthesis_Homo sapiens_hsa007900.49527180
163Mineral absorption_Homo sapiens_hsa049780.49464005
164Shigellosis_Homo sapiens_hsa051310.48959426
165Jak-STAT signaling pathway_Homo sapiens_hsa046300.48387344
166Histidine metabolism_Homo sapiens_hsa003400.47391470
167Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47219877
168Pancreatic secretion_Homo sapiens_hsa049720.44944887
169Dopaminergic synapse_Homo sapiens_hsa047280.42684489
170Fat digestion and absorption_Homo sapiens_hsa049750.42332251

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