EYA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.52352734
2embryonic process involved in female pregnancy (GO:0060136)6.42783205
3transcription from mitochondrial promoter (GO:0006390)6.03567188
4replication fork processing (GO:0031297)5.69114799
5regulation of integrin activation (GO:0033623)5.61671793
6proline metabolic process (GO:0006560)5.33593144
7positive regulation of protein homooligomerization (GO:0032464)5.32101473
8establishment of apical/basal cell polarity (GO:0035089)5.26221613
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.80408567
10regulation of translational fidelity (GO:0006450)4.63036135
11mitotic G1 DNA damage checkpoint (GO:0031571)4.59747452
12establishment or maintenance of monopolar cell polarity (GO:0061339)4.49705870
13establishment of monopolar cell polarity (GO:0061162)4.49705870
14regulation of protein homooligomerization (GO:0032462)4.45840124
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.44126375
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.44126375
17response to pheromone (GO:0019236)4.40040383
18oxidative demethylation (GO:0070989)4.35160879
19mitochondrial DNA metabolic process (GO:0032042)4.32386875
20DNA strand renaturation (GO:0000733)4.23975977
21spliceosomal tri-snRNP complex assembly (GO:0000244)4.22224491
22mRNA cleavage (GO:0006379)4.17420806
23dosage compensation (GO:0007549)4.16352331
24embryonic placenta development (GO:0001892)4.15421003
25pre-miRNA processing (GO:0031054)4.14207900
26negative regulation of DNA-dependent DNA replication (GO:2000104)4.07413150
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.06587230
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.06587230
29positive regulation of mitotic sister chromatid separation (GO:1901970)4.06587230
30mitotic G1/S transition checkpoint (GO:0044819)4.05440879
31regulation of RNA export from nucleus (GO:0046831)4.02485536
32synapsis (GO:0007129)4.02184640
33G1 DNA damage checkpoint (GO:0044783)3.99753173
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.97648795
35regulation of sister chromatid cohesion (GO:0007063)3.89587272
36formation of translation preinitiation complex (GO:0001731)3.88555853
37regulation of DNA endoreduplication (GO:0032875)3.73746390
38poly(A)+ mRNA export from nucleus (GO:0016973)3.69948109
39apoptotic process involved in morphogenesis (GO:0060561)3.69918490
40lactate metabolic process (GO:0006089)3.68928564
41cellular response to zinc ion (GO:0071294)3.68088329
42ketone body metabolic process (GO:1902224)3.65256466
43water-soluble vitamin biosynthetic process (GO:0042364)3.64511004
44negative regulation of JAK-STAT cascade (GO:0046426)3.64455026
45signal peptide processing (GO:0006465)3.62868347
46trophectodermal cell differentiation (GO:0001829)3.58313592
47positive regulation of protein oligomerization (GO:0032461)3.55261052
48respiratory chain complex IV assembly (GO:0008535)3.52591558
49base-excision repair (GO:0006284)3.52271002
50cellular ketone body metabolic process (GO:0046950)3.46720237
51regulation of gene silencing by RNA (GO:0060966)3.46569864
52regulation of posttranscriptional gene silencing (GO:0060147)3.46569864
53regulation of gene silencing by miRNA (GO:0060964)3.46569864
54histone H4-K12 acetylation (GO:0043983)3.45666424
55negative regulation of cell cycle arrest (GO:0071157)3.43245221
56DNA deamination (GO:0045006)3.40772117
57negative regulation of fatty acid biosynthetic process (GO:0045717)3.39737051
58mitotic sister chromatid segregation (GO:0000070)3.39419020
59negative regulation of mRNA processing (GO:0050686)3.37824041
60DNA topological change (GO:0006265)3.36867434
61positive regulation of chromosome segregation (GO:0051984)3.34735537
62recombinational repair (GO:0000725)3.30571198
63double-strand break repair via homologous recombination (GO:0000724)3.29936888
64cellular response to ATP (GO:0071318)3.27959678
65regulation of nuclear cell cycle DNA replication (GO:0033262)3.26830830
66meiotic chromosome segregation (GO:0045132)3.26576311
67heterochromatin organization (GO:0070828)3.22451591
68nodal signaling pathway (GO:0038092)3.21849580
69telomere maintenance via semi-conservative replication (GO:0032201)3.21009169
70regulation of meiosis I (GO:0060631)3.20615034
71regulation of hexokinase activity (GO:1903299)3.20580689
72regulation of glucokinase activity (GO:0033131)3.20580689
73regulation of hippo signaling (GO:0035330)3.20151863
74proteasome assembly (GO:0043248)3.18397490
75negative regulation of RNA splicing (GO:0033119)3.15151379
76regulation of protein oligomerization (GO:0032459)3.14637925
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.12452828
78negative regulation of translation, ncRNA-mediated (GO:0040033)3.12452828
79regulation of translation, ncRNA-mediated (GO:0045974)3.12452828
80viral mRNA export from host cell nucleus (GO:0046784)3.12022520
81protein K6-linked ubiquitination (GO:0085020)3.11187367
82sister chromatid segregation (GO:0000819)3.09816623
83mitotic nuclear envelope disassembly (GO:0007077)3.09576661
84regulation of nucleobase-containing compound transport (GO:0032239)3.08847080
85cytochrome complex assembly (GO:0017004)3.08720998
86embryonic camera-type eye development (GO:0031076)3.08634872
87histone H2A acetylation (GO:0043968)3.07831820
88positive regulation by host of viral transcription (GO:0043923)3.04865494
89anatomical structure regression (GO:0060033)3.03966803
90prenylation (GO:0097354)3.03860463
91protein prenylation (GO:0018342)3.03860463
92cullin deneddylation (GO:0010388)3.03761099
93regulation of double-strand break repair (GO:2000779)3.02501032
94labyrinthine layer development (GO:0060711)3.00859381
95regulation of DNA damage checkpoint (GO:2000001)2.98201961
96intracellular estrogen receptor signaling pathway (GO:0030520)2.97711575
97termination of RNA polymerase II transcription (GO:0006369)2.96070477
98convergent extension (GO:0060026)2.95968393
99protein polyglutamylation (GO:0018095)2.94871393
100negative regulation of Ras GTPase activity (GO:0034261)2.93390415
101regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.93338029
102negative regulation of protein oligomerization (GO:0032460)2.92630244
103keratinocyte development (GO:0003334)2.92577057
104RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91960509
105regulation of protein polyubiquitination (GO:1902914)2.91435011
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.90345781
107DNA integration (GO:0015074)2.89744555
108negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.89469860
109membrane disassembly (GO:0030397)2.89301773
110nuclear envelope disassembly (GO:0051081)2.89301773
111glutamine family amino acid biosynthetic process (GO:0009084)2.89170992
112protein localization to endosome (GO:0036010)2.89033869
113DNA double-strand break processing (GO:0000729)2.86442887
114negative regulation of mRNA metabolic process (GO:1903312)2.86442189
115face development (GO:0060324)2.85408147
116determination of adult lifespan (GO:0008340)2.84969941
117cornea development in camera-type eye (GO:0061303)2.84733211
118double-strand break repair via nonhomologous end joining (GO:0006303)2.81990736
119non-recombinational repair (GO:0000726)2.81990736
120positive regulation of histone H3-K4 methylation (GO:0051571)2.81841793
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.80302343
122regulation of cell size (GO:0008361)2.79033749
123rRNA methylation (GO:0031167)2.78892416
124regulation of type B pancreatic cell apoptotic process (GO:2000674)2.78672854
125DNA strand elongation involved in DNA replication (GO:0006271)2.77997862
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77534989
127L-fucose catabolic process (GO:0042355)2.76669676
128fucose catabolic process (GO:0019317)2.76669676
129L-fucose metabolic process (GO:0042354)2.76669676
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76413025
131regulation of podosome assembly (GO:0071801)2.76346536
132rRNA modification (GO:0000154)2.75673668
133protein deneddylation (GO:0000338)2.74751842
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74449238
135tryptophan catabolic process (GO:0006569)2.74029551
136indole-containing compound catabolic process (GO:0042436)2.74029551
137indolalkylamine catabolic process (GO:0046218)2.74029551
138activation of Rac GTPase activity (GO:0032863)2.73808028
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71912384
140isotype switching (GO:0045190)2.71912384
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71912384
142mRNA transport (GO:0051028)2.71587354
143protein localization to kinetochore (GO:0034501)2.71021488
144nuclear pore organization (GO:0006999)2.70827208
145reciprocal meiotic recombination (GO:0007131)2.70735222
146reciprocal DNA recombination (GO:0035825)2.70735222
147nuclear envelope organization (GO:0006998)2.69270988
148mitochondrial RNA metabolic process (GO:0000959)2.68684834
149telomere maintenance via recombination (GO:0000722)2.68497628
150inositol phosphate catabolic process (GO:0071545)2.68055659
151polyol catabolic process (GO:0046174)2.64338292
152maturation of 5.8S rRNA (GO:0000460)2.63248087
153regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.61844668
154centriole replication (GO:0007099)2.61389759
155piRNA metabolic process (GO:0034587)2.60075834
156platelet dense granule organization (GO:0060155)2.55787747
157male meiosis I (GO:0007141)2.55774209
158preassembly of GPI anchor in ER membrane (GO:0016254)2.55140045
159regulation of acyl-CoA biosynthetic process (GO:0050812)2.54547823
160DNA catabolic process, exonucleolytic (GO:0000738)2.54340218
161indolalkylamine metabolic process (GO:0006586)2.53328825
162intraciliary transport (GO:0042073)2.53250623
163photoreceptor cell maintenance (GO:0045494)2.52253880
164resolution of meiotic recombination intermediates (GO:0000712)2.52001182
165postreplication repair (GO:0006301)2.51796756
166kynurenine metabolic process (GO:0070189)2.51017545
167regulation of neurotransmitter uptake (GO:0051580)2.49438641
168* double-strand break repair (GO:0006302)2.49396843
169kinetochore organization (GO:0051383)2.46909204
170histone exchange (GO:0043486)2.46691394
171kinetochore assembly (GO:0051382)2.46462139
172regulation of centriole replication (GO:0046599)2.46297577
173somite rostral/caudal axis specification (GO:0032525)2.46119804
174peptidyl-histidine modification (GO:0018202)2.42623079
175tryptophan metabolic process (GO:0006568)2.42388847
176detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41393405
177phosphorylated carbohydrate dephosphorylation (GO:0046838)2.41042872
178inositol phosphate dephosphorylation (GO:0046855)2.41042872
179DNA methylation involved in gamete generation (GO:0043046)2.40923142
180response to nitrosative stress (GO:0051409)2.40764589
181cilium morphogenesis (GO:0060271)2.40291475
182protein K11-linked deubiquitination (GO:0035871)2.40137734
183L-methionine salvage (GO:0071267)2.39590824
184L-methionine biosynthetic process (GO:0071265)2.39590824
185amino acid salvage (GO:0043102)2.39590824
186anterograde synaptic vesicle transport (GO:0048490)2.39016591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.68695182
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.33859818
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25454433
4ZNF274_21170338_ChIP-Seq_K562_Hela3.08460653
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05833568
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85451586
7VDR_22108803_ChIP-Seq_LS180_Human2.65288937
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59145568
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.58967926
10MYC_22102868_ChIP-Seq_BL_Human2.56060900
11VDR_21846776_ChIP-Seq_THP-1_Human2.53493547
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49382117
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.43897431
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41440377
15* GABP_17652178_ChIP-ChIP_JURKAT_Human2.38373993
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34982625
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.33045568
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.33045568
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.33045568
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.30042428
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27727049
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22473322
23GBX2_23144817_ChIP-Seq_PC3_Human2.22149451
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21848726
25EWS_26573619_Chip-Seq_HEK293_Human2.21705245
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.19298282
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.18009198
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16902792
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.12750618
30FUS_26573619_Chip-Seq_HEK293_Human2.12019321
31IGF1R_20145208_ChIP-Seq_DFB_Human2.09175586
32* ELK1_19687146_ChIP-ChIP_HELA_Human2.08862777
33P300_19829295_ChIP-Seq_ESCs_Human2.07554315
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.03743310
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00053823
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97418913
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96230406
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.91955644
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88687683
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.88681556
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.88324311
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87389041
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80204791
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79924778
45* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75134948
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74082375
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.72907766
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70410788
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69623552
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.67175036
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66788313
52POU5F1_16518401_ChIP-PET_MESCs_Mouse1.65306503
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65297344
54TAF15_26573619_Chip-Seq_HEK293_Human1.64002248
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61954669
56KDM2B_26808549_Chip-Seq_DND41_Human1.61158600
57LXR_22292898_ChIP-Seq_THP-1_Human1.60733696
58BCAT_22108803_ChIP-Seq_LS180_Human1.60313421
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.60211656
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60082309
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59911954
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58451301
63* VDR_23849224_ChIP-Seq_CD4+_Human1.58001245
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53583613
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53291002
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52410633
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52385481
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52342129
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51833332
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49558891
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.49280380
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48766380
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47095461
74* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47086780
75ER_23166858_ChIP-Seq_MCF-7_Human1.46649699
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46145738
77TCF7_22412390_ChIP-Seq_EML_Mouse1.45209142
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45136148
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.41892570
80ZNF263_19887448_ChIP-Seq_K562_Human1.41787057
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41761615
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41459468
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41093472
84* SMAD4_21799915_ChIP-Seq_A2780_Human1.40321168
85MYC_18940864_ChIP-ChIP_HL60_Human1.40179504
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.39599467
87FOXP3_21729870_ChIP-Seq_TREG_Human1.38355778
88STAT3_23295773_ChIP-Seq_U87_Human1.38125688
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.37486617
90* ELK3_25401928_ChIP-Seq_HUVEC_Human1.37362040
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35678707
92MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35599990
93* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35596063
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.35567961
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34765676
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33858502
97* RACK7_27058665_Chip-Seq_MCF-7_Human1.31514694
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.31397605
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.31226982
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30354441
101ETS1_20019798_ChIP-Seq_JURKAT_Human1.30204818
102CBP_20019798_ChIP-Seq_JUKART_Human1.29528369
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29528369
104NANOG_19829295_ChIP-Seq_ESCs_Human1.29416581
105SOX2_19829295_ChIP-Seq_ESCs_Human1.29416581
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28896688
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28286670
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27640376
109MAF_26560356_Chip-Seq_TH1_Human1.27292351
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27046972
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27012661
112* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26593778
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26388266
114* TCF4_23295773_ChIP-Seq_U87_Human1.26167179
115TFEB_21752829_ChIP-Seq_HELA_Human1.25319149
116TP53_22573176_ChIP-Seq_HFKS_Human1.25069530
117NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24996796
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.24864072
119* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24708062
120AR_25329375_ChIP-Seq_VCAP_Human1.24453583
121TCF4_22108803_ChIP-Seq_LS180_Human1.21472413
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21229245
123P53_22387025_ChIP-Seq_ESCs_Mouse1.20843783
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20831564
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20506130
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19904479
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19600170
128CDX2_22108803_ChIP-Seq_LS180_Human1.19474812
129* KDM5A_27292631_Chip-Seq_BREAST_Human1.17643934
130PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16944967
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.16791186
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16181140
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16006588
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15820417
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13081591
136FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13081270
137FOXA1_25329375_ChIP-Seq_VCAP_Human1.13081270
138SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12853313
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12299076
140* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12214431
141* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12188411
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12086606
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12086606
144STAT3_18555785_Chip-Seq_ESCs_Mouse1.11951090
145P300_18555785_Chip-Seq_ESCs_Mouse1.11843460
146* PHF8_20622853_ChIP-Seq_HELA_Human1.11701023
147E2F1_18555785_Chip-Seq_ESCs_Mouse1.11486760
148* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11431352
149UTX_26944678_Chip-Seq_JUKART_Human1.10993350
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10934992
151POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09361702
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09183846
153* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09029091
154KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08131290
155TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07799224
156SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07479869
157NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07032525
158* RBPJ_21746931_ChIP-Seq_IB4_Human1.06870740
159* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06723343
160CMYC_18555785_Chip-Seq_ESCs_Mouse1.06490166
161* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06328775
162SMAD4_21741376_ChIP-Seq_EPCs_Human1.05522212
163FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05294860
164CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05106024
165CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04921318
166* NFYB_21822215_ChIP-Seq_K562_Human1.04869098
167ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04665771
168* ETV1_20927104_ChIP-Seq_GIST48_Human1.04443086
169MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04319852
170* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04003879
171TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03839035
172NCOR1_26117541_ChIP-Seq_K562_Human1.03834782
173PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03825863
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03794600
175NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03599813
176ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02759291
177ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02544895
178VDR_24763502_ChIP-Seq_THP-1_Human1.01757667
179NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00963642
180E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00603221
181ATF3_27146783_Chip-Seq_COLON_Human0.99930495
182MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98944377
183SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98860955
184* GABP_19822575_ChIP-Seq_HepG2_Human0.98762034
185SALL1_21062744_ChIP-ChIP_HESCs_Human0.98516002
186* TET1_21451524_ChIP-Seq_MESCs_Mouse0.98129728
187POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97516082
188GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97219566
189THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97067196
190SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96690022
191BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96116074
192SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95417682
193HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95239236
194XRN2_22483619_ChIP-Seq_HELA_Human0.95146678
195ETS1_21867929_ChIP-Seq_TH2_Mouse0.92968115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.21170341
2MP0009278_abnormal_bone_marrow3.93507871
3MP0002102_abnormal_ear_morphology3.32309164
4MP0003787_abnormal_imprinting3.12025602
5MP0002837_dystrophic_cardiac_calcinosis3.06683144
6MP0005076_abnormal_cell_differentiation2.91395792
7MP0004233_abnormal_muscle_weight2.83781664
8MP0000372_irregular_coat_pigmentation2.77886656
9MP0010030_abnormal_orbit_morphology2.75861416
10MP0003195_calcinosis2.73579336
11MP0010352_gastrointestinal_tract_polyps2.72392079
12MP0010094_abnormal_chromosome_stability2.59630734
13MP0005171_absent_coat_pigmentation2.35727878
14MP0006292_abnormal_olfactory_placode2.27644722
15MP0004957_abnormal_blastocyst_morpholog2.22024203
16MP0003111_abnormal_nucleus_morphology2.19372332
17MP0002938_white_spotting2.17996574
18MP0003890_abnormal_embryonic-extraembry2.16554286
19MP0005397_hematopoietic_system_phenotyp2.10291293
20MP0001545_abnormal_hematopoietic_system2.10291293
21MP0002163_abnormal_gland_morphology2.08228058
22MP0003705_abnormal_hypodermis_morpholog2.07866747
23MP0002009_preneoplasia1.98251412
24MP0003077_abnormal_cell_cycle1.93098651
25MP0002086_abnormal_extraembryonic_tissu1.90225753
26MP0005379_endocrine/exocrine_gland_phen1.88685366
27MP0003718_maternal_effect1.85598752
28MP0002638_abnormal_pupillary_reflex1.84796005
29MP0005253_abnormal_eye_physiology1.83577063
30MP0010307_abnormal_tumor_latency1.83498656
31MP0003693_abnormal_embryo_hatching1.82563745
32MP0004197_abnormal_fetal_growth/weight/1.78129511
33MP0003646_muscle_fatigue1.75168027
34MP0002084_abnormal_developmental_patter1.74994084
35MP0001697_abnormal_embryo_size1.74171688
36MP0005380_embryogenesis_phenotype1.69462662
37MP0001672_abnormal_embryogenesis/_devel1.69462662
38MP0005075_abnormal_melanosome_morpholog1.68572706
39MP0003567_abnormal_fetal_cardiomyocyte1.66756678
40MP0001730_embryonic_growth_arrest1.63939949
41MP0005551_abnormal_eye_electrophysiolog1.62609085
42MP0003453_abnormal_keratinocyte_physiol1.62454332
43MP0000350_abnormal_cell_proliferation1.62256914
44MP0003119_abnormal_digestive_system1.61063315
45MP0000427_abnormal_hair_cycle1.60237403
46MP0002085_abnormal_embryonic_tissue1.60174191
47MP0005174_abnormal_tail_pigmentation1.58515239
48MP0002653_abnormal_ependyma_morphology1.56318703
49MP0002876_abnormal_thyroid_physiology1.56108376
50MP0000631_abnormal_neuroendocrine_gland1.52283872
51MP0000569_abnormal_digit_pigmentation1.51376815
52MP0003566_abnormal_cell_adhesion1.50868540
53MP0009780_abnormal_chondrocyte_physiolo1.50740626
54MP0000490_abnormal_crypts_of1.50628755
55MP0003283_abnormal_digestive_organ1.50270097
56MP0003984_embryonic_growth_retardation1.49458669
57MP0001293_anophthalmia1.48451737
58MP0005645_abnormal_hypothalamus_physiol1.46276322
59MP0002088_abnormal_embryonic_growth/wei1.45600049
60MP0009697_abnormal_copulation1.42053718
61MP0003121_genomic_imprinting1.41779157
62MP0000371_diluted_coat_color1.40391765
63MP0008932_abnormal_embryonic_tissue1.38295320
64MP0003172_abnormal_lysosome_physiology1.38186412
65MP0008007_abnormal_cellular_replicative1.36460240
66MP0005058_abnormal_lysosome_morphology1.34493421
67MP0008995_early_reproductive_senescence1.34007246
68MP0005646_abnormal_pituitary_gland1.33921600
69MP0008058_abnormal_DNA_repair1.32688827
70MP0004133_heterotaxia1.32074274
71MP0001968_abnormal_touch/_nociception1.31732463
72MP0008877_abnormal_DNA_methylation1.31261141
73MP0009046_muscle_twitch1.30322558
74MP0002080_prenatal_lethality1.29072142
75MP0005220_abnormal_exocrine_pancreas1.28345391
76MP0002160_abnormal_reproductive_system1.27783306
77MP0004264_abnormal_extraembryonic_tissu1.27077417
78MP0003786_premature_aging1.26584425
79MP0008872_abnormal_physiological_respon1.25901452
80MP0002736_abnormal_nociception_after1.25363751
81MP0002269_muscular_atrophy1.24795852
82MP0000685_abnormal_immune_system1.23841730
83MP0004885_abnormal_endolymph1.22985589
84MP0001929_abnormal_gametogenesis1.22103726
85MP0004147_increased_porphyrin_level1.21800243
86MP0004215_abnormal_myocardial_fiber1.19485102
87MP0001485_abnormal_pinna_reflex1.19431534
88MP0002928_abnormal_bile_duct1.18540033
89MP0001944_abnormal_pancreas_morphology1.17567942
90MP0002019_abnormal_tumor_incidence1.16563691
91MP0003828_pulmonary_edema1.14743028
92MP0009333_abnormal_splenocyte_physiolog1.11518402
93MP0001661_extended_life_span1.11248649
94MP0005389_reproductive_system_phenotype1.10281095
95MP0005408_hypopigmentation1.10134886
96MP0002282_abnormal_trachea_morphology1.08693033
97MP0003937_abnormal_limbs/digits/tail_de1.08600508
98MP0001984_abnormal_olfaction1.08308786
99MP0009053_abnormal_anal_canal1.07496717
100MP0010630_abnormal_cardiac_muscle1.07273910
101MP0004043_abnormal_pH_regulation1.06300250
102MP0005410_abnormal_fertilization1.05007761
103MP0002405_respiratory_system_inflammati1.03306082
104MP0005023_abnormal_wound_healing1.03150920
105MP0002210_abnormal_sex_determination1.01058305
106MP0005084_abnormal_gallbladder_morpholo1.00616543
107MP0006036_abnormal_mitochondrial_physio1.00507719
108MP0002693_abnormal_pancreas_physiology1.00263506
109MP0008789_abnormal_olfactory_epithelium0.98502613
110MP0000313_abnormal_cell_death0.98411493
111MP0001324_abnormal_eye_pigmentation0.97451604
112MP0000653_abnormal_sex_gland0.97384218
113MP0002234_abnormal_pharynx_morphology0.95253938
114MP0002111_abnormal_tail_morphology0.95168776
115MP0009115_abnormal_fat_cell0.94450199
116MP0010678_abnormal_skin_adnexa0.94364523
117MP0006054_spinal_hemorrhage0.93841022
118MP0002909_abnormal_adrenal_gland0.90877082
119MP0003698_abnormal_male_reproductive0.90480583
120MP0002249_abnormal_larynx_morphology0.90408867
121MP0000470_abnormal_stomach_morphology0.90354332
122MP0002095_abnormal_skin_pigmentation0.88831763
123MP0001145_abnormal_male_reproductive0.88418910
124MP0005395_other_phenotype0.88224717
125MP0001986_abnormal_taste_sensitivity0.87844473
126MP0006035_abnormal_mitochondrial_morpho0.87800782
127MP0005636_abnormal_mineral_homeostasis0.87712952
128MP0003935_abnormal_craniofacial_develop0.87546246
129MP0000579_abnormal_nail_morphology0.87423860
130MP0003045_fibrosis0.87301949
131MP0006082_CNS_inflammation0.87259311
132MP0000383_abnormal_hair_follicle0.86966725
133MP0002396_abnormal_hematopoietic_system0.86930764
134MP0000647_abnormal_sebaceous_gland0.86398733
135MP0002166_altered_tumor_susceptibility0.85911671
136MP0009745_abnormal_behavioral_response0.85127747
137MP0000689_abnormal_spleen_morphology0.84913770
138MP0002751_abnormal_autonomic_nervous0.84723644
139MP0000613_abnormal_salivary_gland0.84078241
140MP0001915_intracranial_hemorrhage0.82754996
141MP0003806_abnormal_nucleotide_metabolis0.82070146
142MP0003221_abnormal_cardiomyocyte_apopto0.81711744
143MP0002877_abnormal_melanocyte_morpholog0.81267400
144MP0002925_abnormal_cardiovascular_devel0.80419477
145MP0001119_abnormal_female_reproductive0.80370054
146MP0003303_peritoneal_inflammation0.79997978
147MP0003656_abnormal_erythrocyte_physiolo0.79915729
148MP0000703_abnormal_thymus_morphology0.79010551
149MP0005367_renal/urinary_system_phenotyp0.78951280
150MP0000516_abnormal_urinary_system0.78951280
151MP0002398_abnormal_bone_marrow0.78940708
152MP0001501_abnormal_sleep_pattern0.77774471
153MP0002075_abnormal_coat/hair_pigmentati0.77435933
154MP0005332_abnormal_amino_acid0.76991668
155MP0000432_abnormal_head_morphology0.76111042
156MP0002090_abnormal_vision0.75850427
157MP0006072_abnormal_retinal_apoptosis0.75772820
158MP0008775_abnormal_heart_ventricle0.75311864
159MP0004185_abnormal_adipocyte_glucose0.74772838
160MP0002722_abnormal_immune_system0.73176326
161MP0000266_abnormal_heart_morphology0.72440177
162MP0002932_abnormal_joint_morphology0.70513576
163MP0000477_abnormal_intestine_morphology0.70378085
164MP0001756_abnormal_urination0.69691164
165MP0009703_decreased_birth_body0.68998317
166MP0002254_reproductive_system_inflammat0.68951903
167MP0003755_abnormal_palate_morphology0.68670306
168MP0003938_abnormal_ear_development0.68266760
169MP0002006_tumorigenesis0.68122154
170MP0000015_abnormal_ear_pigmentation0.67946516
171MP0002970_abnormal_white_adipose0.67530632
172MP0003448_altered_tumor_morphology0.67021880
173MP0004808_abnormal_hematopoietic_stem0.65445840
174MP0001340_abnormal_eyelid_morphology0.65019982
175MP0000733_abnormal_muscle_development0.63510912
176MP0010155_abnormal_intestine_physiology0.63309187
177MP0005266_abnormal_metabolism0.63236638
178MP0002697_abnormal_eye_size0.63088596

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.54265270
2Facial hemangioma (HP:0000329)4.39944234
3Pustule (HP:0200039)4.38400746
4Ulnar bowing (HP:0003031)4.03670397
5Annular pancreas (HP:0001734)3.89821851
6Hypochromic microcytic anemia (HP:0004840)3.82202534
7Turricephaly (HP:0000262)3.74932369
8Increased IgM level (HP:0003496)3.63595264
9Pancreatic cysts (HP:0001737)3.59236956
10Intestinal fistula (HP:0100819)3.57765221
11Rectal fistula (HP:0100590)3.54746098
12Rectovaginal fistula (HP:0000143)3.54746098
13Short humerus (HP:0005792)3.52324385
14Poikiloderma (HP:0001029)3.51480808
15Pancreatic fibrosis (HP:0100732)3.43748812
16Aplasia/hypoplasia of the humerus (HP:0006507)3.36973985
17Alopecia of scalp (HP:0002293)3.35249807
18Neoplasm of the adrenal cortex (HP:0100641)3.35163538
19Concave nail (HP:0001598)3.34903412
20Tongue fasciculations (HP:0001308)3.20718033
21Vaginal fistula (HP:0004320)3.17421028
22Male infertility (HP:0003251)3.15992856
23Muscle fibrillation (HP:0010546)3.15414272
24Cerebral aneurysm (HP:0004944)3.11645166
25Colon cancer (HP:0003003)3.10111882
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.00883222
27True hermaphroditism (HP:0010459)2.98285197
28Orthostatic hypotension (HP:0001278)2.94678128
29Volvulus (HP:0002580)2.92698698
30Aplasia/Hypoplasia of the fovea (HP:0008060)2.91609649
31Hypoplasia of the fovea (HP:0007750)2.91609649
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88983417
33Decreased circulating renin level (HP:0003351)2.84284368
34Chromsome breakage (HP:0040012)2.83839981
35Basal cell carcinoma (HP:0002671)2.83720584
36Vertebral hypoplasia (HP:0008417)2.81563849
37Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.81563849
38Selective tooth agenesis (HP:0001592)2.73821014
39Abnormality of midbrain morphology (HP:0002418)2.64606136
40Molar tooth sign on MRI (HP:0002419)2.64606136
41Patellar aplasia (HP:0006443)2.64512593
42Methylmalonic acidemia (HP:0002912)2.62706602
43Abnormality of the renal cortex (HP:0011035)2.61325166
44Abnormal hemoglobin (HP:0011902)2.59909406
45Coronal craniosynostosis (HP:0004440)2.59579223
46Absent radius (HP:0003974)2.57775250
47Congenital hip dislocation (HP:0001374)2.57617489
48Broad alveolar ridges (HP:0000187)2.56812455
49Nephronophthisis (HP:0000090)2.56274101
50Polycythemia (HP:0001901)2.55882835
51Pancreatic islet-cell hyperplasia (HP:0004510)2.54838511
52Astrocytoma (HP:0009592)2.54608092
53Abnormality of the astrocytes (HP:0100707)2.54608092
54Increased circulating renin level (HP:0000848)2.54591186
55Squamous cell carcinoma (HP:0002860)2.50043823
56Hypothermia (HP:0002045)2.49862687
57Mucopolysacchariduria (HP:0008155)2.49381510
58Urinary glycosaminoglycan excretion (HP:0003541)2.49381510
59Intestinal atresia (HP:0011100)2.45776093
60Large for gestational age (HP:0001520)2.44400633
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.43528257
62Aplasia/Hypoplasia of the patella (HP:0006498)2.42918199
63Abnormality of the fovea (HP:0000493)2.42498564
64Albinism (HP:0001022)2.42456606
65Thyroiditis (HP:0100646)2.39865200
66Hypochromic anemia (HP:0001931)2.39008000
67IgA deficiency (HP:0002720)2.36993950
68Absent forearm bone (HP:0003953)2.35314168
69Aplasia involving forearm bones (HP:0009822)2.35314168
70Absent thumb (HP:0009777)2.33675619
71Abnormality of the aortic arch (HP:0012303)2.32528013
72Abnormality of male internal genitalia (HP:0000022)2.32257598
73Gaze-evoked nystagmus (HP:0000640)2.32001171
74Congenital stationary night blindness (HP:0007642)2.31422267
75Ependymoma (HP:0002888)2.31043068
76Neoplasm of the adrenal gland (HP:0100631)2.30764504
77Abnormality of chromosome stability (HP:0003220)2.29984033
78Abnormality of the ileum (HP:0001549)2.27472973
79Spinal muscular atrophy (HP:0007269)2.26431842
80Meckel diverticulum (HP:0002245)2.26408170
81Abnormality of the renal medulla (HP:0100957)2.25040821
82Short chin (HP:0000331)2.23227083
83Vertebral fusion (HP:0002948)2.22885334
84Dysautonomia (HP:0002459)2.22243165
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21759280
86Abnormality of polysaccharide metabolism (HP:0011012)2.21759280
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21759280
88Anteriorly placed anus (HP:0001545)2.21327624
89Methylmalonic aciduria (HP:0012120)2.20015342
90Bowed forearm bones (HP:0003956)2.19479757
91Bowing of the arm (HP:0006488)2.19479757
92Abnormality of vitamin B metabolism (HP:0004340)2.19331654
93Hamartoma (HP:0010566)2.17278750
94Cystic liver disease (HP:0006706)2.16074555
95Short 5th finger (HP:0009237)2.15616302
96Metaphyseal cupping (HP:0003021)2.15320023
97Neoplasm of the oral cavity (HP:0100649)2.15211722
98Asymmetric septal hypertrophy (HP:0001670)2.15059290
99Abnormality of the lower motor neuron (HP:0002366)2.14639922
100Medial flaring of the eyebrow (HP:0010747)2.10624043
101Gastrointestinal atresia (HP:0002589)2.08684688
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.08469575
103Abnormality of the labia minora (HP:0012880)2.08151877
104Ectopic kidney (HP:0000086)2.07789869
105Hypotelorism (HP:0000601)2.07318247
106Renal cortical cysts (HP:0000803)2.07009478
107Hyperglycinemia (HP:0002154)2.06627545
108Dysostosis multiplex (HP:0000943)2.06357232
109Diaphragmatic weakness (HP:0009113)2.05759820
110Adrenal hypoplasia (HP:0000835)2.05553321
111Tubular atrophy (HP:0000092)2.05098248
112Hematochezia (HP:0002573)2.04997431
113Ketoacidosis (HP:0001993)2.04978029
114Hyperkalemia (HP:0002153)2.04892648
115Premature skin wrinkling (HP:0100678)2.04223111
116Aqueductal stenosis (HP:0002410)2.02552320
117Abnormality of the duodenum (HP:0002246)2.01603350
118Broad thumb (HP:0011304)2.01276914
119Sloping forehead (HP:0000340)1.99958184
120Severe visual impairment (HP:0001141)1.99945467
121Increased number of teeth (HP:0011069)1.99262429
122Split hand (HP:0001171)1.99137735
123Bile duct proliferation (HP:0001408)1.98872347
124Abnormal biliary tract physiology (HP:0012439)1.98872347
125Capillary hemangiomas (HP:0005306)1.98695619
126Abnormality of the preputium (HP:0100587)1.98492994
127Pendular nystagmus (HP:0012043)1.98316075
128Heterotopia (HP:0002282)1.98146185
129Myocardial infarction (HP:0001658)1.98069475
130Sclerocornea (HP:0000647)1.97965476
131Chronic hepatic failure (HP:0100626)1.97579628
132Increased CSF lactate (HP:0002490)1.95379590
133Attenuation of retinal blood vessels (HP:0007843)1.94822156
134Abnormal rod and cone electroretinograms (HP:0008323)1.94287023
135Acute encephalopathy (HP:0006846)1.93928496
136Furrowed tongue (HP:0000221)1.93606639
137Premature graying of hair (HP:0002216)1.93378314
138Progressive macrocephaly (HP:0004481)1.91494456
139Joint stiffness (HP:0001387)1.88476777
140Abnormality of endocrine pancreas physiology (HP:0012093)1.87152561
141Abnormality of the pancreatic islet cells (HP:0006476)1.87152561
142Hyperinsulinemic hypoglycemia (HP:0000825)1.87067409
143Abolished electroretinogram (ERG) (HP:0000550)1.86945878
144Small intestinal stenosis (HP:0012848)1.85873371
145Duodenal stenosis (HP:0100867)1.85873371
146Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85483979
147Preaxial hand polydactyly (HP:0001177)1.85345191
148Oligodactyly (hands) (HP:0001180)1.85168812
149Congenital malformation of the right heart (HP:0011723)1.83540265
150Double outlet right ventricle (HP:0001719)1.83540265
151Hamartoma of the eye (HP:0010568)1.83478492
152Small hand (HP:0200055)1.83420152
153Glioma (HP:0009733)1.82723146
154Abnormal number of incisors (HP:0011064)1.82525778
155Limb hypertonia (HP:0002509)1.81616120
1563-Methylglutaconic aciduria (HP:0003535)1.81250412
157Choanal stenosis (HP:0000452)1.80252819
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79650378
159Acute necrotizing encephalopathy (HP:0006965)1.79519371
160Hyperacusis (HP:0010780)1.78976947
161Hyperactive renin-angiotensin system (HP:0000841)1.78968331
162Clubbing of toes (HP:0100760)1.78409147
163Hyperventilation (HP:0002883)1.76194603
164Anencephaly (HP:0002323)1.76029656
165Aplasia/Hypoplasia of the macula (HP:0008059)1.76018745
166Hypercortisolism (HP:0001578)1.76004702
167Alacrima (HP:0000522)1.74701634
168Breast carcinoma (HP:0003002)1.74307192
169Colitis (HP:0002583)1.74272411
170Congenital sensorineural hearing impairment (HP:0008527)1.73026875
171Coarse hair (HP:0002208)1.72849850
172Hypoglycemic coma (HP:0001325)1.72744535
173Bilateral sensorineural hearing impairment (HP:0008619)1.72164235
174Supernumerary spleens (HP:0009799)1.71652736
175Acute lymphatic leukemia (HP:0006721)1.71559128
176Abnormal lung lobation (HP:0002101)1.70937037
177Hyperglycemia (HP:0003074)1.70537201
178Aplasia/Hypoplasia of the tibia (HP:0005772)1.69842200
179Abnormal albumin level (HP:0012116)1.69061495
180Hypoalbuminemia (HP:0003073)1.69061495
181Ketosis (HP:0001946)1.68820608
182Bifid uvula (HP:0000193)1.68650834
183Aplasia/Hypoplasia of the spleen (HP:0010451)1.68205879
184Mitochondrial inheritance (HP:0001427)1.67527340
185Hypoplastic ischia (HP:0003175)1.67244267
186Dandy-Walker malformation (HP:0001305)1.67088554
187Genital tract atresia (HP:0001827)1.66056499
188Increased CSF protein (HP:0002922)1.66013160
189Shawl scrotum (HP:0000049)1.64909364
190Generalized amyotrophy (HP:0003700)1.61839371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.09943743
2ICK5.39492846
3DDR24.05240063
4MAP3K63.65678196
5MAPK153.12052987
6NUAK12.86913698
7EIF2AK32.80255013
8CDK122.64142201
9MAP3K112.58895951
10TYRO32.58607914
11WNK32.56266813
12MAP3K102.46370000
13BMPR1B2.41304517
14MATK2.39097822
15TRIM282.38407053
16BMX2.36524988
17PDGFRA2.33045972
18MST42.31799649
19INSRR2.23118949
20FGR2.22123455
21MKNK22.21361729
22PLK22.17718626
23BUB12.12621780
24EIF2AK12.10263114
25TNIK2.06423183
26CSK2.06090181
27PINK11.99743937
28TRIB31.99438912
29CASK1.94225161
30ZAK1.93927024
31PLK41.88544568
32BRSK21.86608320
33PLK31.81981333
34DYRK1B1.75912129
35MAP4K21.73506017
36CDK71.70505712
37GRK11.69764150
38DAPK11.69551540
39STK38L1.68640230
40FGFR21.67090203
41CDK61.65265768
42PIM21.64602974
43PRKD21.63147490
44ADRBK21.61033637
45PIM11.57921280
46TRPM71.52474936
47VRK21.51564578
48YES11.46733193
49UHMK11.38199637
50LATS21.35221483
51MAPK131.30670805
52CDC71.28113405
53TAF11.26940181
54MTOR1.25766373
55MKNK11.23604454
56NEK21.19857725
57AKT31.16923154
58MAP3K41.13846074
59EEF2K1.13453588
60RPS6KL11.10689677
61RPS6KC11.10689677
62NLK1.10447510
63CDC42BPA1.09945146
64MAPK111.05470450
65CHEK21.04457929
66CSNK1G11.03577732
67PAK31.03255021
68MAP2K61.02974932
69STK101.02609173
70VRK11.01740082
71PKN21.01339917
72LATS10.99104015
73STK390.97772583
74PLK10.97341262
75RPS6KA60.96609663
76OXSR10.96383391
77STK30.95743260
78PDK20.94818415
79ALK0.92523143
80TSSK60.91953607
81CSNK1G30.91353416
82RIPK10.91097623
83FER0.88846259
84EIF2AK20.87352176
85SRPK10.85769072
86GSK3A0.85706945
87ATR0.85237620
88RPS6KB20.84825263
89NEK10.84035834
90CSNK1A1L0.83097661
91CDK40.81740307
92WNK40.81180443
93PRKCE0.80588765
94CSNK1G20.78305800
95ERN10.78297101
96RPS6KA10.78128880
97MAP4K10.75105034
98PRKAA10.73623389
99SIK10.71545496
100TTN0.70641748
101PDGFRB0.69621827
102HIPK20.69322962
103PTK2B0.67406174
104CHUK0.67123052
105DYRK30.66278029
106CHEK10.65218511
107* CDK20.64096447
108PNCK0.61280901
109STK40.60301190
110EGFR0.59791493
111EPHA20.59447021
112DAPK20.57965311
113TAOK30.56940702
114TGFBR10.56795313
115BCR0.56265683
116PHKG20.55994366
117PHKG10.55994366
118PRKCG0.55990992
119TTK0.55671037
120STK160.55397044
121BRSK10.55154968
122FLT30.55028993
123PAK40.53403579
124MAP3K80.51718150
125WEE10.51351390
126PRKCI0.50748138
127BRD40.49459525
128AURKB0.48084042
129ERBB30.47185923
130JAK30.45285067
131TLK10.44975737
132ACVR1B0.44401645
133NME10.44283817
134MAPK10.43736911
135MELK0.40831693
136PTK60.40448345
137* ATM0.40413797
138CAMK1G0.39872197
139SIK20.39348382
140JAK20.38561915
141MARK30.38526642
142TEC0.38217537
143NTRK30.37776539
144RPS6KB10.37571288
145CSNK1D0.37315748
146MAPK140.37283751
147FGFR10.37241428
148CDK10.36973211
149IKBKB0.36722072
150PTK20.36399031
151TYK20.36300432
152PRKAA20.36299814
153CSNK1A10.35916651
154CLK10.35766212
155ZAP700.35467257
156TAOK20.34865040
157ADRBK10.34131946
158MAPKAPK30.33868595
159MAPK100.32805218
160MAPK30.32735004
161RAF10.32396014
162MAPKAPK20.31878139
163LYN0.31630739
164TIE10.31399773
165CSNK2A10.30886206
166PAK20.30875511
167AKT10.30190276
168STK110.29677400
169CCNB10.29223559
170STK240.28969112
171MUSK0.27996841
172PRKDC0.27809032
173PBK0.27178148
174SIK30.26019533
175DYRK20.25639272
176MAP2K70.25276112
177PASK0.22886768

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.73709796
2Fatty acid biosynthesis_Homo sapiens_hsa000613.68058665
3Base excision repair_Homo sapiens_hsa034103.61886567
4Protein export_Homo sapiens_hsa030603.55357729
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.31859915
6DNA replication_Homo sapiens_hsa030303.14984865
7Non-homologous end-joining_Homo sapiens_hsa034503.04426513
8Butanoate metabolism_Homo sapiens_hsa006502.53136584
9Proteasome_Homo sapiens_hsa030502.46381092
10Propanoate metabolism_Homo sapiens_hsa006402.37933408
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33864925
12mTOR signaling pathway_Homo sapiens_hsa041502.27107441
13RNA transport_Homo sapiens_hsa030132.12727097
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06220635
15mRNA surveillance pathway_Homo sapiens_hsa030152.04923896
16Notch signaling pathway_Homo sapiens_hsa043302.00658914
17Basal transcription factors_Homo sapiens_hsa030221.98614535
18Vitamin B6 metabolism_Homo sapiens_hsa007501.97371778
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94864066
20RNA polymerase_Homo sapiens_hsa030201.92638556
21Adherens junction_Homo sapiens_hsa045201.85994151
22Spliceosome_Homo sapiens_hsa030401.81359625
23Cell cycle_Homo sapiens_hsa041101.80338160
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75215041
25p53 signaling pathway_Homo sapiens_hsa041151.71305350
26Lysine degradation_Homo sapiens_hsa003101.69059394
27One carbon pool by folate_Homo sapiens_hsa006701.60089830
28Hippo signaling pathway_Homo sapiens_hsa043901.59950278
29Phototransduction_Homo sapiens_hsa047441.58490767
30Nucleotide excision repair_Homo sapiens_hsa034201.56271012
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55184686
32Oxidative phosphorylation_Homo sapiens_hsa001901.54421034
33Sulfur metabolism_Homo sapiens_hsa009201.46504275
34Homologous recombination_Homo sapiens_hsa034401.43830068
35Chronic myeloid leukemia_Homo sapiens_hsa052201.41886495
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40687381
37Tryptophan metabolism_Homo sapiens_hsa003801.38822908
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38698776
39Nitrogen metabolism_Homo sapiens_hsa009101.38663990
40Viral myocarditis_Homo sapiens_hsa054161.38221234
41Hedgehog signaling pathway_Homo sapiens_hsa043401.36628766
42Fanconi anemia pathway_Homo sapiens_hsa034601.36097163
43Steroid biosynthesis_Homo sapiens_hsa001001.35870232
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34898731
45Biosynthesis of amino acids_Homo sapiens_hsa012301.34736360
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32436222
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.29806310
48MicroRNAs in cancer_Homo sapiens_hsa052061.28620693
49Shigellosis_Homo sapiens_hsa051311.26239778
50Fatty acid elongation_Homo sapiens_hsa000621.25225758
51Peroxisome_Homo sapiens_hsa041461.22730243
52TGF-beta signaling pathway_Homo sapiens_hsa043501.18867073
53Circadian rhythm_Homo sapiens_hsa047101.18391359
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18137989
55Bladder cancer_Homo sapiens_hsa052191.15940880
56Parkinsons disease_Homo sapiens_hsa050121.14344747
57Legionellosis_Homo sapiens_hsa051341.13690333
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.13244243
59Small cell lung cancer_Homo sapiens_hsa052221.10170530
60Viral carcinogenesis_Homo sapiens_hsa052031.09521169
61Ether lipid metabolism_Homo sapiens_hsa005651.09432930
62Caffeine metabolism_Homo sapiens_hsa002321.06916042
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05168030
64Acute myeloid leukemia_Homo sapiens_hsa052211.05158161
65Colorectal cancer_Homo sapiens_hsa052101.04187590
66VEGF signaling pathway_Homo sapiens_hsa043701.03054691
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02917174
68Herpes simplex infection_Homo sapiens_hsa051681.01495436
69Purine metabolism_Homo sapiens_hsa002301.01432132
70Linoleic acid metabolism_Homo sapiens_hsa005911.00939127
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00841858
72Primary immunodeficiency_Homo sapiens_hsa053401.00496929
73Regulation of autophagy_Homo sapiens_hsa041401.00172786
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99476722
75Dorso-ventral axis formation_Homo sapiens_hsa043200.96356697
76Basal cell carcinoma_Homo sapiens_hsa052170.96030986
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95149014
78Arginine and proline metabolism_Homo sapiens_hsa003300.91212940
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89021220
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85648685
81Oocyte meiosis_Homo sapiens_hsa041140.85342469
82Pyrimidine metabolism_Homo sapiens_hsa002400.85079892
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84237593
84Fructose and mannose metabolism_Homo sapiens_hsa000510.83575316
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83042813
86HTLV-I infection_Homo sapiens_hsa051660.82919089
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81955441
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81929242
89Huntingtons disease_Homo sapiens_hsa050160.81917965
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.81656678
91Glutathione metabolism_Homo sapiens_hsa004800.81270860
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.80775918
93AMPK signaling pathway_Homo sapiens_hsa041520.80261916
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79921922
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.79187374
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78654928
97Proteoglycans in cancer_Homo sapiens_hsa052050.78178595
98Thyroid cancer_Homo sapiens_hsa052160.76739814
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75497613
100Hepatitis B_Homo sapiens_hsa051610.75006679
101Selenocompound metabolism_Homo sapiens_hsa004500.74828133
102Insulin signaling pathway_Homo sapiens_hsa049100.74623914
103Sulfur relay system_Homo sapiens_hsa041220.74272299
104Arginine biosynthesis_Homo sapiens_hsa002200.73982982
105Epstein-Barr virus infection_Homo sapiens_hsa051690.73834366
106Measles_Homo sapiens_hsa051620.73468045
107B cell receptor signaling pathway_Homo sapiens_hsa046620.73095014
108Retinol metabolism_Homo sapiens_hsa008300.72539482
109Wnt signaling pathway_Homo sapiens_hsa043100.72518241
110Apoptosis_Homo sapiens_hsa042100.71424576
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70993486
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70805875
113Pancreatic cancer_Homo sapiens_hsa052120.70077980
114Metabolic pathways_Homo sapiens_hsa011000.68527261
115Endometrial cancer_Homo sapiens_hsa052130.66971053
116Antigen processing and presentation_Homo sapiens_hsa046120.66190835
117Fatty acid metabolism_Homo sapiens_hsa012120.65065467
118Alzheimers disease_Homo sapiens_hsa050100.62022189
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61526196
120HIF-1 signaling pathway_Homo sapiens_hsa040660.61442744
121Chemical carcinogenesis_Homo sapiens_hsa052040.61146536
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60514864
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59876421
124Insulin secretion_Homo sapiens_hsa049110.59743381
125Pyruvate metabolism_Homo sapiens_hsa006200.57197506
126Collecting duct acid secretion_Homo sapiens_hsa049660.56632465
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56347554
128Focal adhesion_Homo sapiens_hsa045100.55469078
129Olfactory transduction_Homo sapiens_hsa047400.55268368
130beta-Alanine metabolism_Homo sapiens_hsa004100.54466439
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53734750
132Taste transduction_Homo sapiens_hsa047420.53203186
133Sphingolipid metabolism_Homo sapiens_hsa006000.52567406
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52337144
135Prostate cancer_Homo sapiens_hsa052150.51833331
136Fatty acid degradation_Homo sapiens_hsa000710.51455240
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50910508
138Tight junction_Homo sapiens_hsa045300.50727299
139Galactose metabolism_Homo sapiens_hsa000520.50577862
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.49536704
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48333254
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47643519
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47335617
144Folate biosynthesis_Homo sapiens_hsa007900.47162766
145Nicotine addiction_Homo sapiens_hsa050330.46091687
146Non-small cell lung cancer_Homo sapiens_hsa052230.45582870
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44389601
148NF-kappa B signaling pathway_Homo sapiens_hsa040640.43914525
149Pathways in cancer_Homo sapiens_hsa052000.43861288
150Prolactin signaling pathway_Homo sapiens_hsa049170.43807111
151Insulin resistance_Homo sapiens_hsa049310.43782521
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43605601
153Mineral absorption_Homo sapiens_hsa049780.43531962
154Maturity onset diabetes of the young_Homo sapiens_hsa049500.42613633
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42301305
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42093864
157Leishmaniasis_Homo sapiens_hsa051400.42015421
158ErbB signaling pathway_Homo sapiens_hsa040120.39384341
159Choline metabolism in cancer_Homo sapiens_hsa052310.38426811
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38337210
161SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38321975
162RNA degradation_Homo sapiens_hsa030180.37444553
163FoxO signaling pathway_Homo sapiens_hsa040680.36533524
164ABC transporters_Homo sapiens_hsa020100.36076493
165RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35802755
166Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35544944
167Type I diabetes mellitus_Homo sapiens_hsa049400.30203494
168N-Glycan biosynthesis_Homo sapiens_hsa005100.28490068
169Serotonergic synapse_Homo sapiens_hsa047260.27927371
170Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23931964

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