EYA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)6.63117722
2sarcoplasmic reticulum calcium ion transport (GO:0070296)6.00069793
3regulation of secondary heart field cardioblast proliferation (GO:0003266)5.90994571
4regulation of cardioblast proliferation (GO:0003264)5.90994571
5regulation of relaxation of muscle (GO:1901077)5.80074900
6metanephric mesenchyme development (GO:0072075)5.77278968
7kidney mesenchyme development (GO:0072074)5.51971112
8sarcomere organization (GO:0045214)5.42454441
9myofibril assembly (GO:0030239)5.24053624
10skeletal muscle contraction (GO:0003009)5.14621478
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.09991437
12response to muscle activity (GO:0014850)4.92129171
13collagen fibril organization (GO:0030199)4.74958643
14chondrocyte proliferation (GO:0035988)4.73346643
15response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.67230667
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.63929519
17cardiac myofibril assembly (GO:0055003)4.53661122
18regulation of cell communication by electrical coupling (GO:0010649)4.44810108
19striated muscle contraction (GO:0006941)4.36588854
20embryonic cranial skeleton morphogenesis (GO:0048701)4.30571739
21* middle ear morphogenesis (GO:0042474)4.26628306
22regulation of heart morphogenesis (GO:2000826)4.25945769
23bone trabecula formation (GO:0060346)4.19912635
24muscle cell cellular homeostasis (GO:0046716)4.16436724
25response to inactivity (GO:0014854)4.16015940
26negative regulation of chondrocyte differentiation (GO:0032331)4.12024084
27regulation of actin filament-based movement (GO:1903115)4.10958226
28regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.05473687
29aorta morphogenesis (GO:0035909)4.02258498
30actomyosin structure organization (GO:0031032)4.00230145
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.94257316
32skeletal muscle adaptation (GO:0043501)3.93014194
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.88967439
34protein heterotrimerization (GO:0070208)3.78766327
35sequestering of extracellular ligand from receptor (GO:0035581)3.74930998
36G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.73102338
37myotube cell development (GO:0014904)3.70629464
38skeletal muscle fiber development (GO:0048741)3.70154175
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.69610243
40plasma membrane repair (GO:0001778)3.64204278
41axon extension involved in axon guidance (GO:0048846)3.61216583
42neuron projection extension involved in neuron projection guidance (GO:1902284)3.61216583
43cardiac muscle contraction (GO:0060048)3.59009520
44positive regulation of mesenchymal cell proliferation (GO:0002053)3.54946599
45regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.54417666
46cochlea morphogenesis (GO:0090103)3.51034831
47muscle contraction (GO:0006936)3.49924020
48mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.48112451
49skeletal muscle tissue development (GO:0007519)3.44724781
50motile cilium assembly (GO:0044458)3.43817567
51striated muscle atrophy (GO:0014891)3.43389865
52organ induction (GO:0001759)3.42047847
53endodermal cell differentiation (GO:0035987)3.41521160
54cardiac muscle hypertrophy (GO:0003300)3.36872675
55regulation of organ formation (GO:0003156)3.36256579
56glycogen catabolic process (GO:0005980)3.35743591
57hippo signaling (GO:0035329)3.35156925
58muscle atrophy (GO:0014889)3.34639881
59negative regulation of potassium ion transmembrane transport (GO:1901380)3.30668653
60negative regulation of fatty acid transport (GO:2000192)3.30229056
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.30042120
62muscle fiber development (GO:0048747)3.29483152
63nuclear pore complex assembly (GO:0051292)3.28934808
64regulation of skeletal muscle contraction (GO:0014819)3.28261033
65mesenchymal-epithelial cell signaling (GO:0060638)3.25094817
66striated muscle hypertrophy (GO:0014897)3.19163536
67muscle system process (GO:0003012)3.18812051
68regulation of mesenchymal cell proliferation (GO:0010464)3.17681816
69negative regulation of cartilage development (GO:0061037)3.14918307
70striated muscle adaptation (GO:0014888)3.10712751
71cardiac muscle cell development (GO:0055013)3.10082272
72pharyngeal system development (GO:0060037)3.09394272
73glucan catabolic process (GO:0009251)3.04962708
74axonemal dynein complex assembly (GO:0070286)3.04413023
75muscle tissue morphogenesis (GO:0060415)3.03674992
76muscle organ development (GO:0007517)3.03475551
77muscle structure development (GO:0061061)3.02062242
78myoblast migration (GO:0051451)3.01892912
79nuclear pore organization (GO:0006999)2.99168519
80embryonic skeletal joint morphogenesis (GO:0060272)2.95950989
81outflow tract morphogenesis (GO:0003151)2.95706032
82myoblast fusion (GO:0007520)2.95587139
83muscle organ morphogenesis (GO:0048644)2.93810639
84face morphogenesis (GO:0060325)2.93470002
85striated muscle cell development (GO:0055002)2.91497394
86regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.91434535
87skeletal muscle tissue regeneration (GO:0043403)2.91282426
88carnitine shuttle (GO:0006853)2.90395309
89adult heart development (GO:0007512)2.89934262
90collagen metabolic process (GO:0032963)2.89915103
91regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89553797
92camera-type eye morphogenesis (GO:0048593)2.88687118
93cell adhesion mediated by integrin (GO:0033627)2.88493914
94muscle cell fate commitment (GO:0042693)2.87751244
95actin-mediated cell contraction (GO:0070252)2.85590723
96regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.85216785
97cardiac muscle tissue morphogenesis (GO:0055008)2.85051266
98regulation of striated muscle contraction (GO:0006942)2.84309362
99cardiac cell development (GO:0055006)2.84217323
100collagen catabolic process (GO:0030574)2.82812088
101lateral sprouting from an epithelium (GO:0060601)2.82452399
102positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.81025272
103muscle filament sliding (GO:0030049)2.80685412
104actin-myosin filament sliding (GO:0033275)2.80685412
105muscle hypertrophy (GO:0014896)2.80354952
106negative regulation of embryonic development (GO:0045992)2.79787416
107muscle cell migration (GO:0014812)2.79346082
108mesenchyme morphogenesis (GO:0072132)2.78995682
109regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78445395
110cellular polysaccharide catabolic process (GO:0044247)2.76281645
111establishment of mitotic spindle orientation (GO:0000132)2.76261770
112craniofacial suture morphogenesis (GO:0097094)2.75719363
113regulation of cardiac muscle cell contraction (GO:0086004)2.74985673
114syncytium formation by plasma membrane fusion (GO:0000768)2.74967224
115negative regulation of cell fate specification (GO:0009996)2.73291996
116mesenchyme development (GO:0060485)2.72871349
117regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.72493531
118actin filament-based movement (GO:0030048)2.72213082
119eye morphogenesis (GO:0048592)2.70406177
120creatine metabolic process (GO:0006600)2.70079562
121artery morphogenesis (GO:0048844)2.69675889
122carnitine transmembrane transport (GO:1902603)2.69244712
123multicellular organismal macromolecule metabolic process (GO:0044259)2.69144515
124myotube differentiation (GO:0014902)2.68755503
125ganglion development (GO:0061548)2.68740739
126mitotic chromosome condensation (GO:0007076)2.67360437
127syncytium formation (GO:0006949)2.67223409
128dorsal/ventral axis specification (GO:0009950)2.67099289
129muscle cell development (GO:0055001)2.65301427
130paraxial mesoderm development (GO:0048339)2.64602482
131cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.64352469
132genitalia morphogenesis (GO:0035112)2.63650679
133otic vesicle formation (GO:0030916)2.62956337
134cell proliferation involved in metanephros development (GO:0072203)2.61767956
135positive regulation of smoothened signaling pathway (GO:0045880)2.60680934
136fibroblast migration (GO:0010761)2.59991193
137mesenchymal to epithelial transition (GO:0060231)2.59919027
138epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59601252
139negative regulation of protein localization to cell surface (GO:2000009)2.59050653
140metanephros development (GO:0001656)2.57926906
141Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.56073756
142positive regulation of extracellular matrix organization (GO:1903055)2.56062746
143insulin-like growth factor receptor signaling pathway (GO:0048009)2.55693304
144negative regulation of vascular permeability (GO:0043116)2.55641736
145negative regulation of catenin import into nucleus (GO:0035414)2.55493692
146embryonic skeletal system morphogenesis (GO:0048704)2.54553851
147multicellular organismal catabolic process (GO:0044243)2.54464115
148protein localization to cell surface (GO:0034394)2.54337933
149regulation of chondrocyte differentiation (GO:0032330)2.52908652
150notochord development (GO:0030903)2.52877908
151striated muscle tissue development (GO:0014706)2.52683905
152skin morphogenesis (GO:0043589)2.51953219
153left/right pattern formation (GO:0060972)2.51850850
154bone morphogenesis (GO:0060349)2.51520925
155gastrulation with mouth forming second (GO:0001702)2.51382673
156multicellular organismal metabolic process (GO:0044236)2.51225535
157mesonephric tubule development (GO:0072164)2.51007126
158cartilage morphogenesis (GO:0060536)2.50371248
159regulation of establishment of planar polarity (GO:0090175)2.50069102
160auditory receptor cell differentiation (GO:0042491)2.48842155
161establishment of mitotic spindle localization (GO:0040001)2.48408504
162regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.48202866
163regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.48123405
164non-canonical Wnt signaling pathway (GO:0035567)2.48022617
165epithelial cell-cell adhesion (GO:0090136)2.47907337
166epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.47829719
167regulation of transforming growth factor beta2 production (GO:0032909)2.46897211
168cellular response to vitamin (GO:0071295)2.46746213
169positive regulation of cation channel activity (GO:2001259)2.45132548
170response to caffeine (GO:0031000)2.43971040
171polysaccharide catabolic process (GO:0000272)2.43376875
172cytoplasmic microtubule organization (GO:0031122)2.42752526
173muscle adaptation (GO:0043500)2.41174516
174positive regulation of vascular permeability (GO:0043117)2.40182031
175fatty acid transmembrane transport (GO:1902001)2.39849893
176response to activity (GO:0014823)2.39819549
177proximal/distal pattern formation (GO:0009954)2.38843681
178cilium movement (GO:0003341)2.37677930
179carnitine transport (GO:0015879)2.34174783
180amino-acid betaine transport (GO:0015838)2.34174783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.08976530
2E2F7_22180533_ChIP-Seq_HELA_Human3.88165268
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19918173
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.06244046
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81621656
6* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.71301120
7EZH2_22144423_ChIP-Seq_EOC_Human2.70014550
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.64613066
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.60867475
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.37670921
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36453454
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28293802
13* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.28084007
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.24477624
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.23661007
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.23645315
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22400400
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.20274671
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13962151
20CJUN_26792858_Chip-Seq_BT549_Human2.13797331
21GBX2_23144817_ChIP-Seq_PC3_Human2.10834739
22ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04962643
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.99156362
24* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.98459944
25AR_21909140_ChIP-Seq_LNCAP_Human1.96598866
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91985821
27* BRD4_25478319_ChIP-Seq_HGPS_Human1.89498339
28CLOCK_20551151_ChIP-Seq_293T_Human1.84544559
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84167036
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80886465
31TP53_18474530_ChIP-ChIP_U2OS_Human1.79808797
32* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78555856
33* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78555856
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78075476
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75697165
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74255909
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.61256283
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57546344
39TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56413625
40MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.55969838
41* SOX9_26525672_Chip-Seq_HEART_Mouse1.53900565
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53183794
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.51719904
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50386356
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49560692
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47463036
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.46705913
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45003982
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44930184
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44453838
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.42573135
52TP53_16413492_ChIP-PET_HCT116_Human1.41998401
53AHR_22903824_ChIP-Seq_MCF-7_Human1.40894522
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40298167
55NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.39827514
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39120032
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38974741
58* ISL1_27105846_Chip-Seq_CPCs_Mouse1.38932489
59* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38899858
60* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38899858
61ZNF263_19887448_ChIP-Seq_K562_Human1.37109627
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36644935
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36399500
64ZNF274_21170338_ChIP-Seq_K562_Hela1.35840496
65FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33896308
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33492233
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32705936
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.32645550
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31540217
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.30340917
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.29330264
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.29241533
73* TP53_20018659_ChIP-ChIP_R1E_Mouse1.28934833
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28546187
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28546187
76EWS_26573619_Chip-Seq_HEK293_Human1.28387776
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25045436
78* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22730102
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22271647
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21952670
81* STAT3_23295773_ChIP-Seq_U87_Human1.21676304
82* RNF2_27304074_Chip-Seq_ESCs_Mouse1.20990017
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20222757
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20152226
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19923131
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.18460196
87FUS_26573619_Chip-Seq_HEK293_Human1.17720654
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17187795
89GATA4_21415370_ChIP-Seq_HL-1_Mouse1.15429373
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.14943005
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.14943005
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.14774324
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.14635723
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13253906
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12453906
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12447587
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.11948643
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11425807
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11209178
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.10807969
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09080373
102* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08487692
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06184071
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05208132
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04847283
106TAF15_26573619_Chip-Seq_HEK293_Human1.04415303
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04273140
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03248311
109* RING1B_27294783_Chip-Seq_NPCs_Mouse1.02114819
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01206127
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01039131
112FOXM1_23109430_ChIP-Seq_U2OS_Human1.00863421
113* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00758438
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00474442
115* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00243194
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.99975997
117AR_25329375_ChIP-Seq_VCAP_Human0.99785918
118BCAT_22108803_ChIP-Seq_LS180_Human0.99615447
119* GF1B_26923725_Chip-Seq_HPCs_Mouse0.99389097
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98953511
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98153702
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98153702
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98117534
124AR_19668381_ChIP-Seq_PC3_Human0.97512487
125* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97045977
126TBL1_22424771_ChIP-Seq_293T_Human0.96216367
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95676548
128AR_21572438_ChIP-Seq_LNCaP_Human0.95484398
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95474493
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95026596
131* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94793478
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94588124
133VDR_24787735_ChIP-Seq_THP-1_Human0.94335121
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93426253
135NFYB_21822215_ChIP-Seq_K562_Human0.93185319
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91985992
137* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91899146
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91635689
139* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91132006
140P300_19829295_ChIP-Seq_ESCs_Human0.90324335
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89827428
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89678212
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89498916
144* TCF4_23295773_ChIP-Seq_U87_Human0.89456767
145TP53_22127205_ChIP-Seq_IMR90_Human0.89228713
146TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89032963
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88951290
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87456871
149IGF1R_20145208_ChIP-Seq_DFB_Human0.87359358
150POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87154066
151PHF8_20622853_ChIP-Seq_HELA_Human0.85858415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.31757607
2MP0003646_muscle_fatigue4.29075331
3MP0005503_abnormal_tendon_morphology3.75811160
4MP0010030_abnormal_orbit_morphology3.53625396
5MP0004036_abnormal_muscle_relaxation3.31566335
6MP0004084_abnormal_cardiac_muscle3.25274400
7MP0005275_abnormal_skin_tensile3.23453705
8MP0003705_abnormal_hypodermis_morpholog2.89881891
9MP0000733_abnormal_muscle_development2.87078842
10MP0009250_abnormal_appendicular_skeleto2.83437564
11MP0000747_muscle_weakness2.59161686
12MP0000534_abnormal_ureter_morphology2.34632437
13MP0002249_abnormal_larynx_morphology2.32784763
14MP0003942_abnormal_urinary_system2.28911523
15MP0005623_abnormal_meninges_morphology2.25114498
16MP0001299_abnormal_eye_distance/2.15431187
17MP0003279_aneurysm2.10433349
18MP0005330_cardiomyopathy2.08560216
19MP0009384_cardiac_valve_regurgitation2.07625690
20MP0000013_abnormal_adipose_tissue1.99856807
21MP0005508_abnormal_skeleton_morphology1.98218289
22MP0005620_abnormal_muscle_contractility1.96297680
23MP0004145_abnormal_muscle_electrophysio1.95440060
24MP0003385_abnormal_body_wall1.94023144
25MP0000569_abnormal_digit_pigmentation1.93276199
26MP0004215_abnormal_myocardial_fiber1.92949712
27MP0001346_abnormal_lacrimal_gland1.91536643
28MP0002108_abnormal_muscle_morphology1.88510976
29MP0002233_abnormal_nose_morphology1.84839590
30MP0009053_abnormal_anal_canal1.82869725
31MP0004134_abnormal_chest_morphology1.82602950
32* MP0000049_abnormal_middle_ear1.81514086
33MP0002932_abnormal_joint_morphology1.80041901
34MP0003937_abnormal_limbs/digits/tail_de1.79027972
35MP0003878_abnormal_ear_physiology1.76697722
36MP0005377_hearing/vestibular/ear_phenot1.76697722
37* MP0003755_abnormal_palate_morphology1.71431137
38MP0004130_abnormal_muscle_cell1.69409598
39MP0002282_abnormal_trachea_morphology1.68353288
40MP0004272_abnormal_basement_membrane1.67238846
41MP0005187_abnormal_penis_morphology1.65656688
42MP0000751_myopathy1.64996721
43MP0000428_abnormal_craniofacial_morphol1.60203148
44MP0002234_abnormal_pharynx_morphology1.58804236
45MP0001958_emphysema1.51415013
46MP0000762_abnormal_tongue_morphology1.50474224
47MP0000516_abnormal_urinary_system1.50045877
48MP0005367_renal/urinary_system_phenotyp1.50045877
49MP0002972_abnormal_cardiac_muscle1.49703412
50MP0001661_extended_life_span1.47646073
51MP0005257_abnormal_intraocular_pressure1.46879207
52MP0008789_abnormal_olfactory_epithelium1.45403179
53MP0002896_abnormal_bone_mineralization1.43549556
54MP0000163_abnormal_cartilage_morphology1.42584926
55MP0010630_abnormal_cardiac_muscle1.42412031
56MP0005076_abnormal_cell_differentiation1.42090227
57MP0006138_congestive_heart_failure1.41617427
58MP0003879_abnormal_hair_cell1.41216266
59MP0000537_abnormal_urethra_morphology1.40341691
60MP0003935_abnormal_craniofacial_develop1.39378516
61MP0002116_abnormal_craniofacial_bone1.39096127
62MP0002115_abnormal_skeleton_extremities1.38207716
63MP0000678_abnormal_parathyroid_gland1.38054156
64MP0005248_abnormal_Harderian_gland1.36996344
65MP0003566_abnormal_cell_adhesion1.35095112
66MP0002177_abnormal_outer_ear1.33760818
67MP0002060_abnormal_skin_morphology1.31881675
68MP0002109_abnormal_limb_morphology1.29495748
69MP0003115_abnormal_respiratory_system1.29104504
70MP0000749_muscle_degeneration1.28603188
71MP0008775_abnormal_heart_ventricle1.28466679
72MP0000759_abnormal_skeletal_muscle1.27768547
73MP0003137_abnormal_impulse_conducting1.26973742
74MP0003091_abnormal_cell_migration1.26371080
75MP0002332_abnormal_exercise_endurance1.26089841
76MP0005023_abnormal_wound_healing1.25873597
77MP0000432_abnormal_head_morphology1.24613546
78MP0004484_altered_response_of1.22004048
79MP0005451_abnormal_body_composition1.21758837
80MP0003938_abnormal_ear_development1.20845474
81MP0000003_abnormal_adipose_tissue1.20673856
82MP0001485_abnormal_pinna_reflex1.19803150
83MP0004233_abnormal_muscle_weight1.16567759
84MP0010352_gastrointestinal_tract_polyps1.14220526
85MP0005171_absent_coat_pigmentation1.13860108
86MP0002127_abnormal_cardiovascular_syste1.13682503
87MP0003950_abnormal_plasma_membrane1.12379911
88MP0000566_synostosis1.09494802
89MP0003136_yellow_coat_color1.09351277
90MP0000767_abnormal_smooth_muscle1.08946160
91MP0002938_white_spotting1.08640037
92MP0005369_muscle_phenotype1.06294361
93MP0004087_abnormal_muscle_fiber1.05068379
94MP0000372_irregular_coat_pigmentation1.03208774
95MP0006054_spinal_hemorrhage1.03198015
96MP0000383_abnormal_hair_follicle1.02343567
97MP0002113_abnormal_skeleton_development1.02079306
98MP0001544_abnormal_cardiovascular_syste0.99715582
99MP0005385_cardiovascular_system_phenoty0.99715582
100MP0005410_abnormal_fertilization0.98313503
101MP0002295_abnormal_pulmonary_circulatio0.98015813
102MP0002114_abnormal_axial_skeleton0.96145841
103MP0005390_skeleton_phenotype0.95188416
104MP0005266_abnormal_metabolism0.95117291
105MP0010094_abnormal_chromosome_stability0.94071144
106MP0000026_abnormal_inner_ear0.93673383
107MP0010678_abnormal_skin_adnexa0.93304235
108MP0002697_abnormal_eye_size0.92407539
109MP0004185_abnormal_adipocyte_glucose0.92213965
110MP0002111_abnormal_tail_morphology0.92067638
111MP0005197_abnormal_uvea_morphology0.91403964
112MP0000750_abnormal_muscle_regeneration0.91076626
113MP0002092_abnormal_eye_morphology0.90699477
114MP0002106_abnormal_muscle_physiology0.88885720
115MP0001270_distended_abdomen0.88740350
116MP0001340_abnormal_eyelid_morphology0.88635670
117MP0003941_abnormal_skin_development0.87493269
118MP0009697_abnormal_copulation0.85878862
119MP0006036_abnormal_mitochondrial_physio0.84499233
120MP0009780_abnormal_chondrocyte_physiolo0.81731235
121MP0002168_other_aberrant_phenotype0.80836770
122MP0004085_abnormal_heartbeat0.80823653
123MP0008057_abnormal_DNA_replication0.78461314
124* MP0001849_ear_inflammation0.76570118
125MP0002877_abnormal_melanocyte_morpholog0.76155674
126MP0001293_anophthalmia0.75941692
127MP0002089_abnormal_postnatal_growth/wei0.75268550
128MP0008058_abnormal_DNA_repair0.74778482
129MP0002925_abnormal_cardiovascular_devel0.74147636
130MP0009278_abnormal_bone_marrow0.73424184
131MP0002269_muscular_atrophy0.72900812
132MP0003283_abnormal_digestive_organ0.72449364
133MP0000579_abnormal_nail_morphology0.72235022
134MP0000266_abnormal_heart_morphology0.72150478
135MP0004197_abnormal_fetal_growth/weight/0.72113616
136MP0010234_abnormal_vibrissa_follicle0.71644644
137MP0004270_analgesia0.71617074
138MP0002837_dystrophic_cardiac_calcinosis0.71406659
139MP0005670_abnormal_white_adipose0.65509124
140MP0002084_abnormal_developmental_patter0.63043397
141MP0002971_abnormal_brown_adipose0.62877573
142MP0005375_adipose_tissue_phenotype0.60430117
143MP0003077_abnormal_cell_cycle0.58611003
144MP0010307_abnormal_tumor_latency0.57981996
145MP0003315_abnormal_perineum_morphology0.55471349
146MP0004510_myositis0.54368996
147MP0003221_abnormal_cardiomyocyte_apopto0.53351944
148MP0003984_embryonic_growth_retardation0.52716865

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.11364878
2Premature rupture of membranes (HP:0001788)4.71521243
3Muscle hypertrophy of the lower extremities (HP:0008968)4.62134457
4Calf muscle hypertrophy (HP:0008981)4.43577207
5Type 1 muscle fiber predominance (HP:0003803)4.36999396
6EMG: myopathic abnormalities (HP:0003458)3.99668799
7Hyporeflexia of lower limbs (HP:0002600)3.89461220
8Shallow orbits (HP:0000586)3.87097691
9Myopathic facies (HP:0002058)3.86526268
10Rimmed vacuoles (HP:0003805)3.82736017
11Bell-shaped thorax (HP:0001591)3.54117914
12Ankle contracture (HP:0006466)3.47591331
13Aortic dissection (HP:0002647)3.45796811
14Myoglobinuria (HP:0002913)3.45396082
15Lip pit (HP:0100267)3.39223791
16Subaortic stenosis (HP:0001682)3.32214767
17Abnormality of the left ventricular outflow tract (HP:0011103)3.32214767
18Neck muscle weakness (HP:0000467)3.24926714
19Abnormality of dentin (HP:0010299)3.22880885
20Atrophic scars (HP:0001075)3.17403746
21Morphological abnormality of the middle ear (HP:0008609)3.12989768
22Round ear (HP:0100830)3.11994216
23Rhabdomyolysis (HP:0003201)3.08981219
24Broad metatarsal (HP:0001783)3.04104916
25Fetal akinesia sequence (HP:0001989)3.03157204
26Sudden death (HP:0001699)3.02419534
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.99930692
28Malignant hyperthermia (HP:0002047)2.99930147
29Scapular winging (HP:0003691)2.99683605
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.96932190
31Muscle fiber inclusion bodies (HP:0100299)2.96201755
32Hypoplastic ischia (HP:0003175)2.85840926
33Neonatal short-limb short stature (HP:0008921)2.85328292
34Distal arthrogryposis (HP:0005684)2.83409637
35Mixed hearing impairment (HP:0000410)2.81407834
36Aortic aneurysm (HP:0004942)2.81061618
37Cervical subluxation (HP:0003308)2.76219175
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.76157504
39Frequent falls (HP:0002359)2.74247639
40Bundle branch block (HP:0011710)2.71611803
41Cerebral aneurysm (HP:0004944)2.71457344
42Calcaneovalgus deformity (HP:0001848)2.71386319
43Vascular tortuosity (HP:0004948)2.70758026
44Mitral valve prolapse (HP:0001634)2.68665381
45Arterial tortuosity (HP:0005116)2.63849740
46Weak cry (HP:0001612)2.60270101
47Soft skin (HP:0000977)2.59768299
48Increased connective tissue (HP:0009025)2.59304915
49Abnormality of the ischium (HP:0003174)2.57300669
50Microglossia (HP:0000171)2.55616098
51Type 2 muscle fiber atrophy (HP:0003554)2.54901597
52Absent phalangeal crease (HP:0006109)2.54176119
53Deformed tarsal bones (HP:0008119)2.53040154
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49650759
55Short 4th metacarpal (HP:0010044)2.49650759
56Bladder diverticulum (HP:0000015)2.49025025
57Abnormality of the neuromuscular junction (HP:0003398)2.48635266
58Fatigable weakness (HP:0003473)2.48635266
59Mildly elevated creatine phosphokinase (HP:0008180)2.48233710
60Slender build (HP:0001533)2.48113947
61Spinal rigidity (HP:0003306)2.45882601
62Areflexia of lower limbs (HP:0002522)2.44313963
63Increased density of long bones (HP:0006392)2.44239971
64Spinal cord lesions (HP:0100561)2.43813959
65Syringomyelia (HP:0003396)2.43813959
66Follicular hyperkeratosis (HP:0007502)2.42107539
67Lipoatrophy (HP:0100578)2.41595577
68Nemaline bodies (HP:0003798)2.41019774
69Dilatation of the ascending aorta (HP:0005111)2.40780697
70Generalized muscle weakness (HP:0003324)2.37948022
71Muscle stiffness (HP:0003552)2.37204786
72Myotonia (HP:0002486)2.35863457
73Wrist flexion contracture (HP:0001239)2.35170408
74Knee flexion contracture (HP:0006380)2.31325264
75Tarsal synostosis (HP:0008368)2.30967279
76Fragile skin (HP:0001030)2.30516280
77Abnormality of the calcaneus (HP:0008364)2.29876799
78Elbow flexion contracture (HP:0002987)2.28939488
79Limb-girdle muscle atrophy (HP:0003797)2.28364963
80Ulnar deviation of the wrist (HP:0003049)2.28346466
81Mesomelia (HP:0003027)2.28085514
82Muscle fiber atrophy (HP:0100295)2.27974854
83Metatarsus adductus (HP:0001840)2.27127612
84Gowers sign (HP:0003391)2.26129937
85Preauricular pit (HP:0004467)2.25320056
86Periauricular skin pits (HP:0100277)2.25320056
87Peritonitis (HP:0002586)2.25051575
88Hip contracture (HP:0003273)2.25017415
89Exercise-induced muscle cramps (HP:0003710)2.22237591
90Asymmetric septal hypertrophy (HP:0001670)2.22061794
91Abnormal finger flexion creases (HP:0006143)2.21090570
92Genu recurvatum (HP:0002816)2.21084124
93Wormian bones (HP:0002645)2.16757601
94Synostosis involving bones of the feet (HP:0009140)2.14262261
95Synostosis involving bones of the lower limbs (HP:0009138)2.14262261
96Blue sclerae (HP:0000592)2.13755716
97Difficulty running (HP:0009046)2.13715245
98* Dilated cardiomyopathy (HP:0001644)2.13207508
99Proximal amyotrophy (HP:0007126)2.10703041
100Deviation of the hallux (HP:0010051)2.09788635
101Muscular dystrophy (HP:0003560)2.06475350
102EMG: neuropathic changes (HP:0003445)2.05855666
103Pterygium (HP:0001059)2.05592314
104Thin ribs (HP:0000883)2.04980123
105Aplasia of the musculature (HP:0100854)2.03825707
106Increased variability in muscle fiber diameter (HP:0003557)2.02848874
107Difficulty climbing stairs (HP:0003551)2.00497776
108Renal dysplasia (HP:0000110)1.99410603
109Ulnar bowing (HP:0003031)1.99214868
110Hallux valgus (HP:0001822)1.98803721
111Cerebellar dysplasia (HP:0007033)1.98421269
112Aplasia involving bones of the upper limbs (HP:0009823)1.93907247
113Aplasia of the phalanges of the hand (HP:0009802)1.93907247
114Aplasia involving bones of the extremities (HP:0009825)1.93907247
115Spondylolisthesis (HP:0003302)1.93700597
116Hyperkalemia (HP:0002153)1.93098651
117Limited hip movement (HP:0008800)1.92415101
118Bulbar palsy (HP:0001283)1.92201844
119Popliteal pterygium (HP:0009756)1.92058774
120Abnormality of skeletal muscle fiber size (HP:0012084)1.91345742
121Ventricular tachycardia (HP:0004756)1.91290446
122Distal lower limb muscle weakness (HP:0009053)1.91280947
123Buphthalmos (HP:0000557)1.88742482
124Abnormality of the 4th metacarpal (HP:0010012)1.87492935
125Nasolacrimal duct obstruction (HP:0000579)1.86778126
126Fibular aplasia (HP:0002990)1.86271086
127Asymmetry of the thorax (HP:0001555)1.84344916
128Down-sloping shoulders (HP:0200021)1.83563503
129Nonprogressive disorder (HP:0003680)1.83341799
130Long clavicles (HP:0000890)1.82958468
131Broad ribs (HP:0000885)1.82585517
132Abnormality of the shoulder girdle musculature (HP:0001435)1.82472867
133Progressive muscle weakness (HP:0003323)1.82399401
134Mild short stature (HP:0003502)1.79808915
135Overgrowth (HP:0001548)1.79528121
136Camptodactyly of toe (HP:0001836)1.78897388
137Abnormality of the calf musculature (HP:0001430)1.78839716
138Muscle fiber splitting (HP:0003555)1.78579669
139Joint laxity (HP:0001388)1.78167022
140Abnormality of the nasolacrimal system (HP:0000614)1.76775710
141Bowel diverticulosis (HP:0005222)1.75231429
142Broad long bones (HP:0005622)1.74920225
143Epiphyseal dysplasia (HP:0002656)1.74886005
144Amniotic constriction ring (HP:0009775)1.74669958
145Abnormality of placental membranes (HP:0011409)1.74669958
146Exercise-induced myalgia (HP:0003738)1.74270605
147Abnormal ciliary motility (HP:0012262)1.73156730
148Atrial fibrillation (HP:0005110)1.71823458
149Ulnar deviation of finger (HP:0009465)1.71647525
150Short palpebral fissure (HP:0012745)1.71043401
151Respiratory insufficiency due to muscle weakness (HP:0002747)1.70894751
152Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62458406
153Limb-girdle muscle weakness (HP:0003325)1.61008055
154Abnormality of the hip-girdle musculature (HP:0001445)1.58130736
155Abnormality of the musculature of the pelvis (HP:0001469)1.58130736
156Abnormal respiratory motile cilium physiology (HP:0012261)1.56977018
157Shoulder girdle muscle weakness (HP:0003547)1.55493751
158Left ventricular hypertrophy (HP:0001712)1.53978071
159Adducted thumb (HP:0001181)1.53510030
160Cystic hygroma (HP:0000476)1.51636793
161Abnormal respiratory motile cilium morphology (HP:0005938)1.51467973
162Abnormal respiratory epithelium morphology (HP:0012253)1.51467973
163Absent/shortened dynein arms (HP:0200106)1.47388345
164Dynein arm defect of respiratory motile cilia (HP:0012255)1.47388345
165Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.45751759
166Primary atrial arrhythmia (HP:0001692)1.42488866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.88262926
2TTN4.44340541
3LATS13.24520013
4MUSK2.91920480
5SIK12.70454091
6TRIB32.56440721
7PDGFRA2.45474938
8PRKD32.29335620
9ERBB32.08877221
10TRPM72.02181057
11PBK1.95325418
12PDK31.95102357
13PDK41.95102357
14PINK11.89001713
15NEK11.76591405
16STK31.74234404
17TGFBR21.69146992
18RIPK11.66456642
19DMPK1.64602074
20PTK61.59014260
21PAK41.56424047
22BRD41.56181860
23EPHB21.53109379
24FER1.52329750
25MAPK151.51485450
26MST1R1.46893860
27LATS21.45350926
28EPHA31.45268233
29PAK31.44733223
30MARK11.40934953
31PAK21.38938621
32MAP3K101.37666815
33OBSCN1.36942225
34MOS1.29330482
35CAMK1G1.28350524
36FRK1.27797753
37FGFR21.25949906
38TESK11.25190614
39PDK21.17283580
40CDK61.15847283
41NEK91.13556571
42MAP2K31.12316129
43PTK21.12058561
44FGFR11.06651676
45CDK121.06153322
46EEF2K1.06104456
47PKN21.04777550
48PIK3CA1.01044092
49WEE11.00484536
50MTOR1.00224289
51CDK80.99804854
52ERBB40.99211937
53PIK3CG0.98505515
54EPHB10.98150563
55ICK0.97005168
56PDGFRB0.96527434
57BMPR1B0.95915225
58PHKG20.95714791
59PHKG10.95714791
60TTK0.94792330
61PNCK0.91406255
62CCNB10.90879047
63CAMK1D0.90481690
64AKT30.87675915
65PRKAA20.86965636
66MKNK10.85819601
67CDC70.84368861
68MAPKAPK30.84231946
69CSNK1A1L0.84077964
70ROCK10.84066793
71PTK2B0.83106800
72DYRK1B0.81161093
73BRSK20.80579819
74MAPK120.77839450
75RPS6KA40.77745059
76WNK10.77372693
77BMX0.77313876
78NME10.75470735
79MAPKAPK50.74840866
80PRKAA10.74414359
81CAMK2G0.74131236
82ERBB20.73022542
83MAPK110.72570385
84BCR0.67657675
85MAP3K90.66627169
86PLK20.63872813
87MELK0.62035051
88CHEK20.61870161
89ROCK20.60892776
90AURKB0.60876863
91STK390.60837939
92ZAK0.60381170
93CAMK40.59992445
94JAK10.59465413
95PLK10.58948625
96CAMK2D0.56776684
97FGFR30.56619968
98MAP2K10.56586931
99PKN10.56448809
100LIMK10.53524713
101CHEK10.53162734
102RPS6KB10.53148411
103BRAF0.50531870
104TYRO30.49725394
105SRPK10.49515447
106ATR0.49008647
107PLK30.48982848
108SGK30.48380015
109NUAK10.47541913
110MAP2K40.44457728
111MYLK0.44093066
112CSNK1G10.43992164
113ATM0.41747209
114BRSK10.41303089
115MAP3K70.41237911
116MAP3K30.39398258
117SGK20.38973220
118CAMK2A0.38971306
119BCKDK0.38835010
120RAF10.38572838
121CHUK0.38181051
122LRRK20.38036352
123MAP3K20.37916360
124PRKDC0.37842425
125INSR0.37795419
126KSR20.37718410
127CDK40.37577281
128CDK10.37514782
129CDC42BPA0.36677660
130ILK0.36431450
131MAPK130.35668900
132PRKACB0.35101532
133STK38L0.35088049
134PRKCH0.34790093
135CSF1R0.34447763
136RPS6KA20.33810615
137RPS6KB20.33146769
138RPS6KA50.32968764
139WNK40.32708397
140STK380.32594474
141NEK20.32593665
142CDK20.31761756
143NTRK10.31747633
144RPS6KA10.31446754
145FGFR40.31371410
146PRKD10.31000625
147MARK30.30226055
148AKT20.30026631
149PRKG10.29752090
150MET0.29184399
151CDK90.28843488
152SRC0.28609652
153MKNK20.26058664
154PAK60.23823637
155PRKD20.23115825
156CAMKK10.22775017
157GSK3A0.21958513
158CSNK1D0.21846270
159MAPK10.21756671
160PRKCE0.21384167
161CDK30.20782657

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.98991097
2Adherens junction_Homo sapiens_hsa045202.63219765
3Focal adhesion_Homo sapiens_hsa045102.61041898
4Cardiac muscle contraction_Homo sapiens_hsa042602.54124422
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.36610223
6Proteoglycans in cancer_Homo sapiens_hsa052052.31820029
7Basal cell carcinoma_Homo sapiens_hsa052172.30658071
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.24087126
9Hippo signaling pathway_Homo sapiens_hsa043902.21103297
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.06686591
11TGF-beta signaling pathway_Homo sapiens_hsa043502.01748410
12Propanoate metabolism_Homo sapiens_hsa006401.90284838
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85512132
14Dilated cardiomyopathy_Homo sapiens_hsa054141.84950472
15Protein digestion and absorption_Homo sapiens_hsa049741.78649208
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71568932
17Carbon metabolism_Homo sapiens_hsa012001.67224453
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67147079
19MicroRNAs in cancer_Homo sapiens_hsa052061.66799185
20Pyruvate metabolism_Homo sapiens_hsa006201.58999134
21Chronic myeloid leukemia_Homo sapiens_hsa052201.57989623
22Amoebiasis_Homo sapiens_hsa051461.55695596
23Tight junction_Homo sapiens_hsa045301.55294979
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54106659
25Hedgehog signaling pathway_Homo sapiens_hsa043401.50270980
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49944141
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49627416
28Small cell lung cancer_Homo sapiens_hsa052221.49096118
29Prostate cancer_Homo sapiens_hsa052151.47669728
30Non-homologous end-joining_Homo sapiens_hsa034501.47073097
31Nitrogen metabolism_Homo sapiens_hsa009101.47012915
32Melanoma_Homo sapiens_hsa052181.46880896
33Wnt signaling pathway_Homo sapiens_hsa043101.44355228
34Biosynthesis of amino acids_Homo sapiens_hsa012301.42262813
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40353417
36Axon guidance_Homo sapiens_hsa043601.39034510
37Arginine and proline metabolism_Homo sapiens_hsa003301.36718293
38Fanconi anemia pathway_Homo sapiens_hsa034601.35861381
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.35455897
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29565593
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29194370
42Arginine biosynthesis_Homo sapiens_hsa002201.28199012
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.22719944
44DNA replication_Homo sapiens_hsa030301.20166483
45Bladder cancer_Homo sapiens_hsa052191.18936871
46beta-Alanine metabolism_Homo sapiens_hsa004101.17868247
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.17010773
48Notch signaling pathway_Homo sapiens_hsa043301.15996889
49Pentose phosphate pathway_Homo sapiens_hsa000301.15215257
50Malaria_Homo sapiens_hsa051441.14380292
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14020407
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13212329
53Glioma_Homo sapiens_hsa052141.12743601
54HTLV-I infection_Homo sapiens_hsa051661.12017575
55PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11605096
56Colorectal cancer_Homo sapiens_hsa052101.11088743
57Pancreatic cancer_Homo sapiens_hsa052121.09741325
58Nucleotide excision repair_Homo sapiens_hsa034201.08791323
59Calcium signaling pathway_Homo sapiens_hsa040201.06548911
60Insulin resistance_Homo sapiens_hsa049311.05836249
61Pathways in cancer_Homo sapiens_hsa052001.04727420
62Melanogenesis_Homo sapiens_hsa049161.03320269
63Toxoplasmosis_Homo sapiens_hsa051451.02348089
64Viral myocarditis_Homo sapiens_hsa054161.01890765
65Rap1 signaling pathway_Homo sapiens_hsa040151.00782933
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00271043
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98435483
68Phenylalanine metabolism_Homo sapiens_hsa003600.98346056
69Fatty acid degradation_Homo sapiens_hsa000710.97856151
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95847312
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95800446
72mTOR signaling pathway_Homo sapiens_hsa041500.95139484
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95078076
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92442671
75Estrogen signaling pathway_Homo sapiens_hsa049150.92355519
76FoxO signaling pathway_Homo sapiens_hsa040680.90631374
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90325355
78Platelet activation_Homo sapiens_hsa046110.90046413
79Purine metabolism_Homo sapiens_hsa002300.89441803
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89220651
81Endometrial cancer_Homo sapiens_hsa052130.88301087
82Glucagon signaling pathway_Homo sapiens_hsa049220.88135979
83Huntingtons disease_Homo sapiens_hsa050160.86758809
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.86436210
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85612930
86TNF signaling pathway_Homo sapiens_hsa046680.83444310
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83419701
88One carbon pool by folate_Homo sapiens_hsa006700.83303262
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83187288
90Dorso-ventral axis formation_Homo sapiens_hsa043200.81648535
91Renal cell carcinoma_Homo sapiens_hsa052110.81619887
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81382349
93Insulin signaling pathway_Homo sapiens_hsa049100.80914102
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79083656
95Alcoholism_Homo sapiens_hsa050340.77775833
96MAPK signaling pathway_Homo sapiens_hsa040100.77453626
97ABC transporters_Homo sapiens_hsa020100.77117665
98RNA transport_Homo sapiens_hsa030130.74865032
99Basal transcription factors_Homo sapiens_hsa030220.74615959
100Viral carcinogenesis_Homo sapiens_hsa052030.72687212
101Homologous recombination_Homo sapiens_hsa034400.72465348
102Hepatitis B_Homo sapiens_hsa051610.71996715
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.71238691
104Fructose and mannose metabolism_Homo sapiens_hsa000510.70606149
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70518183
106Lysine degradation_Homo sapiens_hsa003100.70264879
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70109025
108Oxytocin signaling pathway_Homo sapiens_hsa049210.68369494
109Mismatch repair_Homo sapiens_hsa034300.67678834
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66497709
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65634199
112Osteoclast differentiation_Homo sapiens_hsa043800.65579830
113Butanoate metabolism_Homo sapiens_hsa006500.64494216
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64445464
115GnRH signaling pathway_Homo sapiens_hsa049120.64156039
116Sulfur relay system_Homo sapiens_hsa041220.64047907
117Salmonella infection_Homo sapiens_hsa051320.64008566
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.62778714
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62632034
120Fatty acid metabolism_Homo sapiens_hsa012120.61959364
121Shigellosis_Homo sapiens_hsa051310.61769547
122Starch and sucrose metabolism_Homo sapiens_hsa005000.61378403
123Circadian rhythm_Homo sapiens_hsa047100.61330662
124Cell cycle_Homo sapiens_hsa041100.59592375
125Leishmaniasis_Homo sapiens_hsa051400.59197659
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58936614
127Tyrosine metabolism_Homo sapiens_hsa003500.57885304
128Prolactin signaling pathway_Homo sapiens_hsa049170.57864465
129Phagosome_Homo sapiens_hsa041450.57561979
130VEGF signaling pathway_Homo sapiens_hsa043700.57111771
131AMPK signaling pathway_Homo sapiens_hsa041520.54608154
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54441786
133Gap junction_Homo sapiens_hsa045400.53702795
134Non-small cell lung cancer_Homo sapiens_hsa052230.53553594
135Alzheimers disease_Homo sapiens_hsa050100.51635001
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.51097546
137Oocyte meiosis_Homo sapiens_hsa041140.50812927
138p53 signaling pathway_Homo sapiens_hsa041150.50493425
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49837837
140Tryptophan metabolism_Homo sapiens_hsa003800.48783522
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.47975993
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47969335
143Systemic lupus erythematosus_Homo sapiens_hsa053220.47399533
144Thyroid cancer_Homo sapiens_hsa052160.46997448
145Antigen processing and presentation_Homo sapiens_hsa046120.46787240
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46743360
147Selenocompound metabolism_Homo sapiens_hsa004500.45722166
148Ovarian steroidogenesis_Homo sapiens_hsa049130.45608653
149HIF-1 signaling pathway_Homo sapiens_hsa040660.45502281
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44295401
151Ras signaling pathway_Homo sapiens_hsa040140.44250255
152Histidine metabolism_Homo sapiens_hsa003400.43702565
153Endocytosis_Homo sapiens_hsa041440.43142533
154mRNA surveillance pathway_Homo sapiens_hsa030150.43074709
155Fatty acid biosynthesis_Homo sapiens_hsa000610.39733349
156Pyrimidine metabolism_Homo sapiens_hsa002400.37946344
157RNA degradation_Homo sapiens_hsa030180.37160590
158Parkinsons disease_Homo sapiens_hsa050120.37056498

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