EZH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)3.77258489
2positive regulation by symbiont of host defense response (GO:0052509)3.66876657
3modulation by symbiont of host defense response (GO:0052031)3.66876657
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66876657
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66876657
6positive regulation by organism of defense response of other organism involved in symbiotic interact3.66876657
7modulation by symbiont of host immune response (GO:0052553)3.66876657
8synaptic vesicle maturation (GO:0016188)3.66217682
9negative regulation of lymphocyte mediated immunity (GO:0002707)3.65531851
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.60110661
11regulation of ARF protein signal transduction (GO:0032012)3.54448849
12B cell receptor signaling pathway (GO:0050853)3.48664066
13negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.48197216
14macrophage activation involved in immune response (GO:0002281)3.43990232
15negative regulation of erythrocyte differentiation (GO:0045647)3.41053728
16sodium ion export (GO:0071436)3.40157348
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38843484
18negative regulation of cell killing (GO:0031342)3.38843484
19detection of other organism (GO:0098543)3.37415783
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.31966499
21detection of bacterium (GO:0016045)3.31023993
22cerebellar Purkinje cell differentiation (GO:0021702)3.30233792
23microglial cell activation (GO:0001774)3.23755104
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.21105976
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19621276
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19621276
27regulation of interferon-beta biosynthetic process (GO:0045357)3.19484794
28potassium ion import (GO:0010107)3.18906825
29negative regulation of T cell mediated immunity (GO:0002710)3.13367724
30activation of protein kinase A activity (GO:0034199)3.13353052
31negative regulation of leukocyte mediated immunity (GO:0002704)3.12817040
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12299397
33phosphatidylinositol dephosphorylation (GO:0046856)3.11035425
34positive regulation of granulocyte differentiation (GO:0030854)3.09027933
35cellular potassium ion homeostasis (GO:0030007)3.07109618
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05366524
37leukocyte aggregation (GO:0070486)3.04897564
38positive regulation of gamma-delta T cell activation (GO:0046645)3.04700758
39antigen processing and presentation of endogenous antigen (GO:0019883)3.04052717
40locomotory exploration behavior (GO:0035641)3.00955245
41phospholipid dephosphorylation (GO:0046839)2.96549183
42protein targeting to Golgi (GO:0000042)2.95757419
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95528824
44regulation of synaptic vesicle exocytosis (GO:2000300)2.94796049
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89920635
46retrograde transport, vesicle recycling within Golgi (GO:0000301)2.85027681
47regulation of beta-amyloid formation (GO:1902003)2.82736454
48cellular extravasation (GO:0045123)2.82569252
49regulation of B cell differentiation (GO:0045577)2.81726526
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76583421
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76196235
52positive regulation of B cell differentiation (GO:0045579)2.74665485
53negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.74475671
54regulation of synaptic vesicle transport (GO:1902803)2.74459281
55germinal center formation (GO:0002467)2.73291041
56synaptic vesicle exocytosis (GO:0016079)2.71434909
57negative thymic T cell selection (GO:0045060)2.70941162
58negative T cell selection (GO:0043383)2.69074385
59detection of external biotic stimulus (GO:0098581)2.68962898
60glutamate secretion (GO:0014047)2.68711430
61macrophage activation (GO:0042116)2.67399603
62regulation of gamma-delta T cell differentiation (GO:0045586)2.64636566
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64108201
64negative regulation of cAMP-mediated signaling (GO:0043951)2.62741191
65mannose metabolic process (GO:0006013)2.62119918
66tolerance induction (GO:0002507)2.61633765
67establishment of protein localization to Golgi (GO:0072600)2.60867391
68neutrophil activation involved in immune response (GO:0002283)2.60635033
69regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.59901985
70regulation of synapse structural plasticity (GO:0051823)2.57468426
71negative regulation of immunoglobulin mediated immune response (GO:0002890)2.57297600
72negative regulation of B cell mediated immunity (GO:0002713)2.57297600
73response to interleukin-15 (GO:0070672)2.57022849
74negative regulation of type 2 immune response (GO:0002829)2.56694011
75regulation of granulocyte differentiation (GO:0030852)2.53607492
76proline transport (GO:0015824)2.53250928
77neutrophil activation (GO:0042119)2.51912068
78negative regulation of T-helper cell differentiation (GO:0045623)2.51744220
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.51744220
80negative regulation of adaptive immune response (GO:0002820)2.50468023
81myeloid cell activation involved in immune response (GO:0002275)2.49871473
82regulation of clathrin-mediated endocytosis (GO:2000369)2.48571822
83T cell selection (GO:0045058)2.48495752
84T cell migration (GO:0072678)2.47748383
85oxygen transport (GO:0015671)2.47109743
86regulation of glutamate receptor signaling pathway (GO:1900449)2.46418284
87positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.45936795
88thymic T cell selection (GO:0045061)2.45106938
89membrane depolarization during action potential (GO:0086010)2.43348353
90regulation of gamma-delta T cell activation (GO:0046643)2.43181830
91negative regulation of dendrite morphogenesis (GO:0050774)2.42468821
92negative regulation of interleukin-12 production (GO:0032695)2.42439549
93relaxation of cardiac muscle (GO:0055119)2.41494563
94regulation of mast cell degranulation (GO:0043304)2.40715582
95response to muramyl dipeptide (GO:0032495)2.38946841
96positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.37517964
97cellular response to epinephrine stimulus (GO:0071872)2.37499378
98negative regulation of glycoprotein biosynthetic process (GO:0010561)2.37454883
99signal complex assembly (GO:0007172)2.36792460
100antigen processing and presentation via MHC class Ib (GO:0002475)2.36595154
101positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.36403716
102positive T cell selection (GO:0043368)2.35028797
103antigen receptor-mediated signaling pathway (GO:0050851)2.35019967
104neurotransmitter secretion (GO:0007269)2.34961269
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.34056484
106regulation of natural killer cell mediated immunity (GO:0002715)2.34056484
107positive thymic T cell selection (GO:0045059)2.34012568
108gas transport (GO:0015669)2.33705624
109regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33573140
110response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33513012
111response to host immune response (GO:0052572)2.33513012
112regulation of tolerance induction (GO:0002643)2.32599101
113regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.32015185
114vocalization behavior (GO:0071625)2.31926278
115regulation of T cell tolerance induction (GO:0002664)2.31277709
116phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.31231870
117respiratory burst (GO:0045730)2.30947251
118immunoglobulin mediated immune response (GO:0016064)2.30729362
119positive regulation of mast cell activation (GO:0033005)2.30004428
120interferon-gamma-mediated signaling pathway (GO:0060333)2.28803385
121regulation of T cell mediated cytotoxicity (GO:0001914)2.28136320
122regulation of mast cell activation involved in immune response (GO:0033006)2.27993569
123regulation of dendritic cell antigen processing and presentation (GO:0002604)2.27982030
124detection of molecule of bacterial origin (GO:0032490)2.27956621
125positive regulation of Rap GTPase activity (GO:0032854)2.27624798
126regulation of germinal center formation (GO:0002634)2.27563407
127detection of biotic stimulus (GO:0009595)2.27341177
128regulation of amyloid precursor protein catabolic process (GO:1902991)2.25967531
129cell communication by electrical coupling (GO:0010644)2.23701835
130regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.23263861
131long-term synaptic potentiation (GO:0060291)2.22680299
132neuronal action potential propagation (GO:0019227)2.21283949
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.21100872
134growth hormone receptor signaling pathway (GO:0060396)2.20167766
135Golgi to endosome transport (GO:0006895)2.19269466
136mitochondrion distribution (GO:0048311)2.19215735
137glycine transport (GO:0015816)2.18587967
138detection of calcium ion (GO:0005513)2.15543273
139striatum development (GO:0021756)2.14227418
140fibroblast migration (GO:0010761)2.14199911
141regulation of glycogen (starch) synthase activity (GO:2000465)2.14004985
142long-term memory (GO:0007616)2.13897755
143positive regulation of cation channel activity (GO:2001259)2.13633369
144regulation of Rap GTPase activity (GO:0032317)2.12154099
145negative regulation of hormone metabolic process (GO:0032351)2.10165503
146negative regulation of hormone biosynthetic process (GO:0032353)2.10165503
147regulation of B cell receptor signaling pathway (GO:0050855)2.09110167
148regulation of interleukin-12 biosynthetic process (GO:0045075)2.08760549
149regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.08070556
150regulation of neuronal synaptic plasticity (GO:0048168)2.06687702
151positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.06402255
152cellular response to interleukin-15 (GO:0071350)2.06111407
153cellular sodium ion homeostasis (GO:0006883)2.05348562
154cell communication involved in cardiac conduction (GO:0086065)2.05146681
155succinate metabolic process (GO:0006105)2.04985880
156membrane repolarization (GO:0086009)2.04314033
157stress fiber assembly (GO:0043149)2.03839509
158regulation of calcium ion transmembrane transporter activity (GO:1901019)2.03484230
159regulation of calcium ion transmembrane transport (GO:1903169)2.03484230
160long term synaptic depression (GO:0060292)2.03463056
161G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.01134603
162regulation of sodium ion transmembrane transporter activity (GO:2000649)2.00634119
163neurotransmitter-gated ion channel clustering (GO:0072578)1.99428708
164regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.98958231
165regulation of ARF GTPase activity (GO:0032312)1.98931608
166ionotropic glutamate receptor signaling pathway (GO:0035235)1.98897207
167regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)1.98854471
168JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)1.98455203
169nerve growth factor signaling pathway (GO:0038180)1.97733729
170negative regulation of stress fiber assembly (GO:0051497)1.97692458
171prepulse inhibition (GO:0060134)1.97086646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27575719
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51319920
3EZH2_22144423_ChIP-Seq_EOC_Human2.28733568
4DROSHA_22980978_ChIP-Seq_HELA_Human2.24422257
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.17454125
6RUNX_20019798_ChIP-Seq_JUKART_Human2.09021149
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.04487337
8BP1_19119308_ChIP-ChIP_Hs578T_Human1.99830487
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88834120
10IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75806628
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75675460
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73189980
13RARB_27405468_Chip-Seq_BRAIN_Mouse1.72358563
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.70225471
15GBX2_23144817_ChIP-Seq_PC3_Human1.65451463
16GATA2_21666600_ChIP-Seq_HMVEC_Human1.64373575
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61251413
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60438588
19* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58428500
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57594244
21GATA1_22025678_ChIP-Seq_K562_Human1.56838386
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53826358
23MYB_26560356_Chip-Seq_TH2_Human1.48771166
24MAF_26560356_Chip-Seq_TH1_Human1.45372175
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.43886516
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42939411
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40100010
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39704495
29* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38675702
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37993086
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36821580
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36685180
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36178677
34SPI1_23127762_ChIP-Seq_K562_Human1.35638658
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33460280
36AHR_22903824_ChIP-Seq_MCF-7_Human1.32506522
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32359091
38SMAD4_21799915_ChIP-Seq_A2780_Human1.32053739
39* GATA1_19941827_ChIP-Seq_MEL_Mouse1.31729831
40UTX_26944678_Chip-Seq_JUKART_Human1.30910678
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30378551
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28953951
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27572952
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26276437
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26260817
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25955654
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25246955
48MAF_26560356_Chip-Seq_TH2_Human1.25085761
49GATA1_19941826_ChIP-Seq_K562_Human1.24503342
50KDM2B_26808549_Chip-Seq_K562_Human1.24394455
51VDR_24763502_ChIP-Seq_THP-1_Human1.24325662
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23013720
53* RUNX1_22412390_ChIP-Seq_EML_Mouse1.22351755
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21732019
55MYB_26560356_Chip-Seq_TH1_Human1.21644593
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21035361
57RXR_22108803_ChIP-Seq_LS180_Human1.20890037
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.20523829
59VDR_21846776_ChIP-Seq_THP-1_Human1.20086756
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16378854
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16219228
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14906428
63KDM2B_26808549_Chip-Seq_DND41_Human1.12860815
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.12618583
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11754475
66REST_21632747_ChIP-Seq_MESCs_Mouse1.11179150
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09170174
68* GATA2_19941826_ChIP-Seq_K562_Human1.08666926
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08103473
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06670582
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06669553
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06499328
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06337598
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06337598
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06277364
76* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06217393
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05677359
78GATA3_27048872_Chip-Seq_THYMUS_Human1.05523806
79BCAT_22108803_ChIP-Seq_LS180_Human1.04873549
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04821180
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04427303
82TCF7_22412390_ChIP-Seq_EML_Mouse1.04247374
83MYC_22102868_ChIP-Seq_BL_Human1.02384060
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01596926
85* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01589672
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00910071
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.00598608
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.99783644
89STAT3_23295773_ChIP-Seq_U87_Human0.99329299
90SPI1_23547873_ChIP-Seq_NB4_Human0.99324835
91* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98957280
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98627777
93* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98614322
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98226234
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98026060
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97714161
97AR_19668381_ChIP-Seq_PC3_Human0.97190264
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.97130822
99OCT4_19829295_ChIP-Seq_ESCs_Human0.96852161
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96789164
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.96658014
102* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96247786
103SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95911288
104AR_21572438_ChIP-Seq_LNCaP_Human0.95287890
105EP300_21415370_ChIP-Seq_HL-1_Mouse0.95214906
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94470590
107AR_25329375_ChIP-Seq_VCAP_Human0.93957760
108SCL_19346495_ChIP-Seq_HPC-7_Human0.93838781
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.93795486
110TBX20_22328084_ChIP-Seq_HEART_Mouse0.93795486
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.93576557
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92392128
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.91958416
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91348404
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91063226
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90911225
117LXR_22292898_ChIP-Seq_THP-1_Human0.89994310
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89801673
119SMRT_27268052_Chip-Seq_Bcells_Human0.89560963
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.88349464
121* GATA3_26560356_Chip-Seq_TH2_Human0.88027453
122JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87503007
123VDR_24787735_ChIP-Seq_THP-1_Human0.86179965
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.85776585
125KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85060470
126BCL6_27268052_Chip-Seq_Bcells_Human0.84301426
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83936935
128TCF4_23295773_ChIP-Seq_U87_Human0.83679833
129JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83375009
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83231561
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82640769
132P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82629345
133BCOR_27268052_Chip-Seq_Bcells_Human0.82076150
134RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81215859
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81067385
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.80482763
137* SMC4_20622854_ChIP-Seq_HELA_Human0.80439373
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80388579
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80296646
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79949985
141RNF2_27304074_Chip-Seq_ESCs_Mouse0.74592810
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74536736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.88313266
2MP0003436_decreased_susceptibility_to2.65103371
3MP0009780_abnormal_chondrocyte_physiolo2.56933833
4MP0010234_abnormal_vibrissa_follicle2.47095781
5MP0004130_abnormal_muscle_cell2.42783921
6MP0004510_myositis2.39662220
7MP0000013_abnormal_adipose_tissue2.25282446
8MP0005670_abnormal_white_adipose2.17146694
9MP0003635_abnormal_synaptic_transmissio2.13535463
10MP0003045_fibrosis2.10232452
11MP0002166_altered_tumor_susceptibility2.10062577
12MP0001501_abnormal_sleep_pattern2.06555022
13MP0002837_dystrophic_cardiac_calcinosis2.04608486
14MP0003646_muscle_fatigue2.04131973
15MP0002822_catalepsy2.04041778
16MP0008961_abnormal_basal_metabolism2.03920721
17MP0002419_abnormal_innate_immunity1.98465591
18MP0000569_abnormal_digit_pigmentation1.94570198
19MP0005666_abnormal_adipose_tissue1.91013263
20MP0005025_abnormal_response_to1.89763138
21MP0002909_abnormal_adrenal_gland1.88468624
22MP0009046_muscle_twitch1.82526188
23MP0008569_lethality_at_weaning1.78596068
24MP0001986_abnormal_taste_sensitivity1.73883238
25MP0002064_seizures1.71682169
26MP0004484_altered_response_of1.71076070
27MP0009745_abnormal_behavioral_response1.70203400
28MP0005058_abnormal_lysosome_morphology1.69580929
29MP0003300_gastrointestinal_ulcer1.63296135
30MP0000751_myopathy1.61480259
31MP0002006_tumorigenesis1.57380883
32MP0002405_respiratory_system_inflammati1.57333397
33MP0005375_adipose_tissue_phenotype1.54291334
34MP0009785_altered_susceptibility_to1.52158845
35MP0004043_abnormal_pH_regulation1.50974077
36MP0005310_abnormal_salivary_gland1.50060267
37MP0002063_abnormal_learning/memory/cond1.49809698
38MP0001835_abnormal_antigen_presentation1.45290899
39MP0002398_abnormal_bone_marrow1.44994827
40MP0003633_abnormal_nervous_system1.43412042
41MP0003656_abnormal_erythrocyte_physiolo1.43293689
42MP0000716_abnormal_immune_system1.43013314
43MP0004270_analgesia1.42767953
44MP0005535_abnormal_body_temperature1.42535386
45MP0005423_abnormal_somatic_nervous1.41128947
46MP0005671_abnormal_response_to1.40430775
47MP0005167_abnormal_blood-brain_barrier1.40159723
48MP0001765_abnormal_ion_homeostasis1.39444926
49MP0004185_abnormal_adipocyte_glucose1.38586977
50MP0000003_abnormal_adipose_tissue1.37502732
51MP0002272_abnormal_nervous_system1.36733040
52MP0003172_abnormal_lysosome_physiology1.35719556
53MP0004036_abnormal_muscle_relaxation1.33428208
54MP0001790_abnormal_immune_system1.32077202
55MP0005387_immune_system_phenotype1.32077202
56MP0001968_abnormal_touch/_nociception1.30313629
57MP0006082_CNS_inflammation1.29824693
58MP0002572_abnormal_emotion/affect_behav1.29346211
59MP0001533_abnormal_skeleton_physiology1.29182970
60MP0003879_abnormal_hair_cell1.28718286
61MP0003183_abnormal_peptide_metabolism1.26672788
62MP0005646_abnormal_pituitary_gland1.24325406
63MP0003866_abnormal_defecation1.20709373
64MP0003828_pulmonary_edema1.20603263
65MP0000689_abnormal_spleen_morphology1.20186216
66MP0002971_abnormal_brown_adipose1.20159735
67MP0003763_abnormal_thymus_physiology1.18317676
68MP0004381_abnormal_hair_follicle1.16526815
69MP0000703_abnormal_thymus_morphology1.15549332
70MP0004215_abnormal_myocardial_fiber1.15009225
71MP0001502_abnormal_circadian_rhythm1.13970435
72MP0003787_abnormal_imprinting1.12648120
73MP0003075_altered_response_to1.11807382
74MP0002722_abnormal_immune_system1.09440040
75MP0002736_abnormal_nociception_after1.08777478
76MP0003724_increased_susceptibility_to1.08760438
77MP0000685_abnormal_immune_system1.08679412
78MP0001984_abnormal_olfaction1.08675122
79MP0002148_abnormal_hypersensitivity_rea1.07823769
80MP0001845_abnormal_inflammatory_respons1.07765165
81MP0002734_abnormal_mechanical_nocicepti1.07158965
82MP0009278_abnormal_bone_marrow1.06622957
83MP0008874_decreased_physiological_sensi1.06428984
84MP0003690_abnormal_glial_cell1.05467778
85MP0001800_abnormal_humoral_immune1.05060046
86MP0000920_abnormal_myelination1.03993961
87MP0004147_increased_porphyrin_level1.01204330
88MP0002429_abnormal_blood_cell1.00764995
89MP0004084_abnormal_cardiac_muscle1.00600629
90MP0010155_abnormal_intestine_physiology1.00264485
91MP0008260_abnormal_autophagy1.00030054
92MP0002928_abnormal_bile_duct0.99621051
93MP0003329_amyloid_beta_deposits0.98298659
94MP0002653_abnormal_ependyma_morphology0.97811111
95MP0002933_joint_inflammation0.97477436
96MP0002638_abnormal_pupillary_reflex0.97337556
97MP0002332_abnormal_exercise_endurance0.97240533
98MP0001851_eye_inflammation0.96300773
99MP0008872_abnormal_physiological_respon0.95312968
100MP0003191_abnormal_cellular_cholesterol0.94263260
101MP0010386_abnormal_urinary_bladder0.94149932
102MP0003631_nervous_system_phenotype0.94132728
103MP0002735_abnormal_chemical_nociception0.94028048
104MP0004858_abnormal_nervous_system0.93912651
105MP0001970_abnormal_pain_threshold0.93272449
106MP0002067_abnormal_sensory_capabilities0.92993533
107MP0009764_decreased_sensitivity_to0.90623136
108MP0003303_peritoneal_inflammation0.90031239
109MP0000604_amyloidosis0.89723588
110MP0003136_yellow_coat_color0.89310513
111MP0002009_preneoplasia0.89129038
112MP0002420_abnormal_adaptive_immunity0.88958504
113MP0002723_abnormal_immune_serum0.88467800
114MP0005464_abnormal_platelet_physiology0.87380265
115MP0001819_abnormal_immune_cell0.86509417
116MP0005000_abnormal_immune_tolerance0.86110142
117MP0002078_abnormal_glucose_homeostasis0.85893464
118MP0001545_abnormal_hematopoietic_system0.85838178
119MP0005397_hematopoietic_system_phenotyp0.85838178
120MP0001486_abnormal_startle_reflex0.85714675
121MP0002090_abnormal_vision0.85251171
122MP0001958_emphysema0.85104447
123MP0002693_abnormal_pancreas_physiology0.84416101
124MP0002277_abnormal_respiratory_mucosa0.84316467
125MP0000465_gastrointestinal_hemorrhage0.84228883
126MP0002138_abnormal_hepatobiliary_system0.83483845
127MP0002396_abnormal_hematopoietic_system0.83359424
128MP0005386_behavior/neurological_phenoty0.83302768
129MP0004924_abnormal_behavior0.83302768
130MP0002733_abnormal_thermal_nociception0.81707213
131MP0003880_abnormal_central_pattern0.80486216
132MP0005551_abnormal_eye_electrophysiolog0.78706521
133MP0004087_abnormal_muscle_fiber0.78696585
134MP0009115_abnormal_fat_cell0.77703590
135MP0002452_abnormal_antigen_presenting0.77617714
136MP0004885_abnormal_endolymph0.77536313
137MP0004947_skin_inflammation0.77423904
138MP0002132_abnormal_respiratory_system0.76683556
139MP0002877_abnormal_melanocyte_morpholog0.76491007
140MP0005620_abnormal_muscle_contractility0.76121669
141MP0009333_abnormal_splenocyte_physiolog0.75111972
142MP0001873_stomach_inflammation0.73991225

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.86927154
2Myositis (HP:0100614)4.12865979
3Visual hallucinations (HP:0002367)3.99077817
4Papilledema (HP:0001085)3.95254713
5Recurrent bacterial skin infections (HP:0005406)3.80055407
6Focal motor seizures (HP:0011153)3.77573168
7Optic neuritis (HP:0100653)3.68502562
8Retrobulbar optic neuritis (HP:0100654)3.68502562
9Orchitis (HP:0100796)3.66556803
10Recurrent abscess formation (HP:0002722)3.61735453
11Stomatitis (HP:0010280)3.56848580
12Gastrointestinal infarctions (HP:0005244)3.43637739
13Febrile seizures (HP:0002373)3.30875658
14Elevated erythrocyte sedimentation rate (HP:0003565)3.27530170
15Hypochromic microcytic anemia (HP:0004840)3.26457698
16Focal seizures (HP:0007359)3.16598097
17Abnormality of the fingertips (HP:0001211)3.16175894
18Mediastinal lymphadenopathy (HP:0100721)3.14826192
19Spontaneous hematomas (HP:0007420)3.09103243
20Meningitis (HP:0001287)3.05770026
21Recurrent fungal infections (HP:0002841)3.05146475
22Abnormality of macrophages (HP:0004311)3.03302928
23Recurrent gram-negative bacterial infections (HP:0005420)3.01005141
24Atonic seizures (HP:0010819)2.92213377
25Obstructive lung disease (HP:0006536)2.88057052
26Chronic obstructive pulmonary disease (HP:0006510)2.88057052
27Dysmetric saccades (HP:0000641)2.88029882
28Hypothermia (HP:0002045)2.87956542
29Prolonged bleeding time (HP:0003010)2.86773749
30Vasculitis (HP:0002633)2.83174654
31Chest pain (HP:0100749)2.81665535
32Action tremor (HP:0002345)2.79719925
33Exercise-induced myalgia (HP:0003738)2.70630594
34Hypochromic anemia (HP:0001931)2.68705844
35Oligomenorrhea (HP:0000876)2.63657350
36Keratoconjunctivitis sicca (HP:0001097)2.61834478
37Agammaglobulinemia (HP:0004432)2.60970152
38Postural instability (HP:0002172)2.58946533
39Encephalitis (HP:0002383)2.56331618
40Ventricular fibrillation (HP:0001663)2.55920622
41Hemoptysis (HP:0002105)2.55791667
42Abnormality of binocular vision (HP:0011514)2.53240394
43Diplopia (HP:0000651)2.53240394
44Pulmonary infiltrates (HP:0002113)2.48945746
45Autoimmune thrombocytopenia (HP:0001973)2.48474569
46Recurrent skin infections (HP:0001581)2.47200677
47Myokymia (HP:0002411)2.46284882
48Obstructive sleep apnea (HP:0002870)2.45567730
49Keratoconjunctivitis (HP:0001096)2.44887721
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44837915
51Resting tremor (HP:0002322)2.43954866
52Gingivitis (HP:0000230)2.43132560
53Progressive cerebellar ataxia (HP:0002073)2.42728441
54Cellulitis (HP:0100658)2.42583012
55Colitis (HP:0002583)2.41883971
56Truncal ataxia (HP:0002078)2.40494260
57Hemiplegia (HP:0002301)2.40097028
58Panhypogammaglobulinemia (HP:0003139)2.38871803
59Chronic mucocutaneous candidiasis (HP:0002728)2.38827499
60Recurrent cutaneous fungal infections (HP:0011370)2.38827499
61Increased cerebral lipofuscin (HP:0011813)2.38172074
62Macroorchidism (HP:0000053)2.37266742
63Recurrent bronchitis (HP:0002837)2.34832211
64Menstrual irregularities (HP:0000858)2.34541051
65Pustule (HP:0200039)2.34189646
66Bundle branch block (HP:0011710)2.33083143
67Ankle clonus (HP:0011448)2.32716382
68Abnormality of the periventricular white matter (HP:0002518)2.31919469
69Pulmonary embolism (HP:0002204)2.29788416
70Gaze-evoked nystagmus (HP:0000640)2.24254107
71T lymphocytopenia (HP:0005403)2.24165143
72Insulin-resistant diabetes mellitus (HP:0000831)2.20824335
73Urinary bladder sphincter dysfunction (HP:0002839)2.20655889
74Genetic anticipation (HP:0003743)2.19782441
75Episodic fever (HP:0001954)2.19644740
76Absence seizures (HP:0002121)2.18847406
77Hyperkalemia (HP:0002153)2.18786345
78Spastic gait (HP:0002064)2.18221671
79Asymmetric septal hypertrophy (HP:0001670)2.17531499
80Supranuclear gaze palsy (HP:0000605)2.15592585
81Abnormality of T cell number (HP:0011839)2.15105882
82Gastrointestinal stroma tumor (HP:0100723)2.13297545
83Myoglobinuria (HP:0002913)2.12663095
84Fatigue (HP:0012378)2.12603332
85Hyperventilation (HP:0002883)2.11733523
86Syncope (HP:0001279)2.11561890
87Difficulty running (HP:0009046)2.11241045
88Hematochezia (HP:0002573)2.09753807
89Papilloma (HP:0012740)2.09025212
90Verrucae (HP:0200043)2.09025212
91Generalized tonic-clonic seizures (HP:0002069)2.09017351
92Peripheral hypomyelination (HP:0007182)2.08327510
93Hyporeflexia of lower limbs (HP:0002600)2.07757353
94Frequent falls (HP:0002359)2.07089865
95Microcytic anemia (HP:0001935)2.06067227
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05460128
97Enlarged penis (HP:0000040)2.04424560
98Urticaria (HP:0001025)2.04152437
99Decreased circulating renin level (HP:0003351)2.03151403
100Abnormality of the heme biosynthetic pathway (HP:0010472)2.02968807
101Global brain atrophy (HP:0002283)2.02358422
102Facial diplegia (HP:0001349)2.02128930
103Epistaxis (HP:0000421)2.02038141
104Absent speech (HP:0001344)2.01639707
105Osteomyelitis (HP:0002754)2.01614610
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01298092
107Intention tremor (HP:0002080)2.01185385
108Recurrent sinusitis (HP:0011108)1.99453683
109Impaired social interactions (HP:0000735)1.98275269
110Abnormal social behavior (HP:0012433)1.98275269
111Leukocytosis (HP:0001974)1.98003430
112Dialeptic seizures (HP:0011146)1.97295882
113Impaired vibration sensation in the lower limbs (HP:0002166)1.95715884
114Vertigo (HP:0002321)1.95355263
115Restrictive lung disease (HP:0002091)1.92435393
116Sepsis (HP:0100806)1.92025357
117Impaired smooth pursuit (HP:0007772)1.91618113
118Granulocytopenia (HP:0001913)1.91309241
119Increased CSF protein (HP:0002922)1.90866335
120Nasal polyposis (HP:0100582)1.90096750
121Lymphopenia (HP:0001888)1.89099073
122Rapidly progressive (HP:0003678)1.88695469
123Abnormality of saccadic eye movements (HP:0000570)1.87003793
124Hyperactive renin-angiotensin system (HP:0000841)1.86294597
125Abnormality of T cells (HP:0002843)1.86069977
126Dysdiadochokinesis (HP:0002075)1.85448044
127Inflammation of the large intestine (HP:0002037)1.85390442
128Prolonged QT interval (HP:0001657)1.84467924
129Dysmetria (HP:0001310)1.83263199
130Spinal canal stenosis (HP:0003416)1.83209119
131Abnormality of ocular smooth pursuit (HP:0000617)1.83023587
132Subcapsular cataract (HP:0000523)1.82566285
133Stomach cancer (HP:0012126)1.81199412
134Acne (HP:0001061)1.80585727
135Slow saccadic eye movements (HP:0000514)1.80564052
136Arterial tortuosity (HP:0005116)1.80028451
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.79383060
138Abnormality of the endocardium (HP:0004306)1.79349420
139Gingival bleeding (HP:0000225)1.79056817
140Gastrointestinal inflammation (HP:0004386)1.78620483
141Abnormal eating behavior (HP:0100738)1.77519872
142Truncal obesity (HP:0001956)1.77486209
143Chronic diarrhea (HP:0002028)1.77396706
144Mask-like facies (HP:0000298)1.77343419
145Increased IgE level (HP:0003212)1.76377181
146Hyperphosphatemia (HP:0002905)1.76297146
147Hand muscle atrophy (HP:0009130)1.76052884
148Growth hormone excess (HP:0000845)1.75983475
149Central scotoma (HP:0000603)1.75681240
150Dysostosis multiplex (HP:0000943)1.75548827
151Depression (HP:0000716)1.74671284
152Epileptic encephalopathy (HP:0200134)1.73652119
153Polycythemia (HP:0001901)1.72509468
154Cerebral aneurysm (HP:0004944)1.72245937
155Thyroiditis (HP:0100646)1.72005461
156Abnormality of the nasal mucosa (HP:0000433)1.71711873
157Urinary urgency (HP:0000012)1.71615594
158Poor eye contact (HP:0000817)1.70158024
159Pheochromocytoma (HP:0002666)1.70073073
160Distal upper limb amyotrophy (HP:0007149)1.69827470
161Upper limb amyotrophy (HP:0009129)1.69827470
162Acanthosis nigricans (HP:0000956)1.67654795
163Abnormality of chloride homeostasis (HP:0011422)1.66792586
164Abnormal delayed hypersensitivity skin test (HP:0002963)1.66626343
165Lower limb asymmetry (HP:0100559)1.66488407
166Muscle fiber splitting (HP:0003555)1.65564753
167Striae distensae (HP:0001065)1.65465708
168Recurrent viral infections (HP:0004429)1.64527671
169Progressive visual loss (HP:0000529)1.64440817
170Neoplasm of the heart (HP:0100544)1.63688608
171Hypokalemic alkalosis (HP:0001949)1.63590597
172Arterial thrombosis (HP:0004420)1.63241062
173Abnormal EKG (HP:0003115)1.63054984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.48425878
2MAP3K132.39702407
3BLK2.38750274
4TAOK32.24958354
5PRPF4B2.19441676
6NTRK32.11175706
7LMTK22.11059851
8RIPK42.00598568
9MAP3K21.98641853
10JAK11.95444544
11KSR21.88465665
12CAMK1D1.78547112
13DAPK21.74293215
14MAP4K11.73671516
15CAMK1G1.71676455
16SGK31.67051745
17MAP2K31.66639160
18PRKCH1.60724522
19IRAK41.59107933
20STK381.58581935
21MAP3K41.58290912
22TIE11.58116960
23ERN11.54957565
24EEF2K1.51609476
25SGK21.51326646
26MAP3K91.48216393
27TRIB31.48151474
28CSK1.45443180
29RIPK11.44197902
30BTK1.37350789
31TXK1.35746768
32FES1.34025849
33FGFR31.28698260
34TYK21.27322583
35INSRR1.20668584
36MAP3K121.20130088
37SGK4941.18732609
38SGK2231.18732609
39MAP3K71.18622928
40RET1.15738312
41TTN1.15722077
42FGFR21.15039210
43PDK11.14983179
44CAMKK11.07909302
45PHKG21.07381930
46PHKG11.07381930
47IKBKE1.05182992
48MAPK131.01763389
49STK110.99814300
50PDPK10.99752978
51WNK10.99066577
52ITK0.98947263
53PTK60.97457977
54MUSK0.94419723
55MAP2K40.93388493
56MAP2K70.93014427
57CAMKK20.92481944
58TNK20.91834551
59MAP3K110.91463644
60JAK20.91429635
61EPHA30.90886411
62DMPK0.90796465
63CDC42BPA0.90083675
64LYN0.89182194
65TGFBR20.89090722
66PRKD30.88031500
67MARK10.87117131
68TAOK10.86177191
69JAK30.85246681
70PRKAA20.84296824
71MAP3K10.83876487
72SIK30.83703905
73MAP3K140.83338236
74MAPK150.82088438
75AKT30.81993412
76MARK30.81635579
77MAPK70.81399593
78CDK190.79368558
79UHMK10.78930687
80MAP3K60.78025633
81SGK10.76782040
82CASK0.75719793
83CAMK10.73376162
84PINK10.72724670
85ZAP700.72292696
86HCK0.71878552
87PDK20.71776042
88PRKCQ0.71391883
89KIT0.71285683
90MAPKAPK30.70770778
91NTRK20.69911547
92PTK2B0.69059093
93NLK0.69027941
94PRKAA10.68556824
95IRAK10.67979855
96TBK10.67926195
97FGR0.67262802
98MAP2K60.66852608
99CAMK40.65973875
100SYK0.65562824
101EPHA40.65113596
102MARK20.64841952
103MAPKAPK50.64742151
104FYN0.64717410
105GRK50.63764358
106GRK60.63585688
107CDK50.63128338
108DYRK1B0.62576948
109DYRK1A0.62117851
110MAPK120.62042299
111PDK40.62019268
112PDK30.62019268
113RAF10.61967983
114BMPR20.61212568
115DAPK10.61144031
116PAK30.58480066
117PAK60.57868138
118MYLK0.57856377
119WNK40.57615092
120TRPM70.56986833
121CDK120.56699651
122TEC0.56519685
123RPS6KA20.56485943
124SIK20.55759370
125PRKD10.54622016
126FGFR40.54500049
127EPHB10.52209259
128MINK10.52057547
129OBSCN0.51661295
130PRKD20.51482792
131STK240.50886366
132IKBKB0.49206243
133YES10.48809493
134OXSR10.47492016
135GRK10.47483986
136LCK0.46827366
137HIPK20.43587165

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047211.93826573
2Olfactory transduction_Homo sapiens_hsa047401.93265871
3Leishmaniasis_Homo sapiens_hsa051401.82676494
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.80668161
5Long-term potentiation_Homo sapiens_hsa047201.69916151
6Graft-versus-host disease_Homo sapiens_hsa053321.67856358
7Allograft rejection_Homo sapiens_hsa053301.67126967
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.67003681
9Autoimmune thyroid disease_Homo sapiens_hsa053201.63335648
10Gastric acid secretion_Homo sapiens_hsa049711.63146239
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62184013
12Circadian entrainment_Homo sapiens_hsa047131.61403499
13Staphylococcus aureus infection_Homo sapiens_hsa051501.60961318
14Salivary secretion_Homo sapiens_hsa049701.54732138
15Type II diabetes mellitus_Homo sapiens_hsa049301.53650282
16Morphine addiction_Homo sapiens_hsa050321.49567812
17Insulin secretion_Homo sapiens_hsa049111.48960329
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44362063
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40833662
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39294751
21Type I diabetes mellitus_Homo sapiens_hsa049401.38588850
22Renin secretion_Homo sapiens_hsa049241.34475499
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33490827
24Nicotine addiction_Homo sapiens_hsa050331.31785293
25Amphetamine addiction_Homo sapiens_hsa050311.31466130
26GABAergic synapse_Homo sapiens_hsa047271.30020182
27Dorso-ventral axis formation_Homo sapiens_hsa043201.28657771
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25448217
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25267276
30Taste transduction_Homo sapiens_hsa047421.25227539
31Glutamatergic synapse_Homo sapiens_hsa047241.24084462
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.23040656
33Cholinergic synapse_Homo sapiens_hsa047251.20494352
34Collecting duct acid secretion_Homo sapiens_hsa049661.20420604
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16901409
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15085602
37Inositol phosphate metabolism_Homo sapiens_hsa005621.14063732
38Oxytocin signaling pathway_Homo sapiens_hsa049211.11843656
39cAMP signaling pathway_Homo sapiens_hsa040241.10693583
40Dopaminergic synapse_Homo sapiens_hsa047281.09933460
41Circadian rhythm_Homo sapiens_hsa047101.08948292
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.08813270
43GnRH signaling pathway_Homo sapiens_hsa049121.08348998
44Calcium signaling pathway_Homo sapiens_hsa040201.04844195
45mTOR signaling pathway_Homo sapiens_hsa041501.04788288
46Malaria_Homo sapiens_hsa051441.03276953
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00968089
48Hematopoietic cell lineage_Homo sapiens_hsa046400.99464619
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98895058
50B cell receptor signaling pathway_Homo sapiens_hsa046620.98561996
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97943536
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.97805073
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97655904
54Measles_Homo sapiens_hsa051620.95906747
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.95503602
56Asthma_Homo sapiens_hsa053100.95355933
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93659134
58Osteoclast differentiation_Homo sapiens_hsa043800.93267651
59Estrogen signaling pathway_Homo sapiens_hsa049150.93197004
60Insulin resistance_Homo sapiens_hsa049310.92611372
61Chemokine signaling pathway_Homo sapiens_hsa040620.91933620
62Other glycan degradation_Homo sapiens_hsa005110.90503298
63T cell receptor signaling pathway_Homo sapiens_hsa046600.89774234
64Cocaine addiction_Homo sapiens_hsa050300.89065148
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88915071
66TNF signaling pathway_Homo sapiens_hsa046680.88191353
67Glioma_Homo sapiens_hsa052140.87331771
68Glucagon signaling pathway_Homo sapiens_hsa049220.86088968
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85243713
70Viral myocarditis_Homo sapiens_hsa054160.84322226
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.84175536
72Insulin signaling pathway_Homo sapiens_hsa049100.84168957
73Dilated cardiomyopathy_Homo sapiens_hsa054140.84026930
74Choline metabolism in cancer_Homo sapiens_hsa052310.83647275
75Long-term depression_Homo sapiens_hsa047300.83549870
76Prolactin signaling pathway_Homo sapiens_hsa049170.82239515
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80741574
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80423776
79Influenza A_Homo sapiens_hsa051640.79808035
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.79755280
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.79181263
82Pancreatic secretion_Homo sapiens_hsa049720.78672567
83Regulation of autophagy_Homo sapiens_hsa041400.78604332
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78495648
85Lysosome_Homo sapiens_hsa041420.76947838
86Primary immunodeficiency_Homo sapiens_hsa053400.75610212
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74982876
88Fatty acid biosynthesis_Homo sapiens_hsa000610.74906738
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74529915
90Renal cell carcinoma_Homo sapiens_hsa052110.74491192
91Antigen processing and presentation_Homo sapiens_hsa046120.74053893
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73554450
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73085144
94Glycerolipid metabolism_Homo sapiens_hsa005610.72634902
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71625785
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.71235899
97Endometrial cancer_Homo sapiens_hsa052130.70175580
98Phagosome_Homo sapiens_hsa041450.69903404
99ABC transporters_Homo sapiens_hsa020100.69868823
100Phototransduction_Homo sapiens_hsa047440.69801675
101Toxoplasmosis_Homo sapiens_hsa051450.68457038
102African trypanosomiasis_Homo sapiens_hsa051430.68048867
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67985539
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67786108
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67416092
106Non-small cell lung cancer_Homo sapiens_hsa052230.67385218
107MAPK signaling pathway_Homo sapiens_hsa040100.66909066
108Platelet activation_Homo sapiens_hsa046110.65730883
109Serotonergic synapse_Homo sapiens_hsa047260.64685573
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63773785
111FoxO signaling pathway_Homo sapiens_hsa040680.63202494
112Hepatitis B_Homo sapiens_hsa051610.63031968
113Endocytosis_Homo sapiens_hsa041440.61053059
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60941682
115VEGF signaling pathway_Homo sapiens_hsa043700.60784384
116Thyroid hormone synthesis_Homo sapiens_hsa049180.60575948
117Bile secretion_Homo sapiens_hsa049760.60120540
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.59945531
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.59806037
120Vibrio cholerae infection_Homo sapiens_hsa051100.59228651
121AMPK signaling pathway_Homo sapiens_hsa041520.58503755
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58180435
123ErbB signaling pathway_Homo sapiens_hsa040120.57965345
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57453801
125Acute myeloid leukemia_Homo sapiens_hsa052210.57237399
126Rheumatoid arthritis_Homo sapiens_hsa053230.56406817
127Hepatitis C_Homo sapiens_hsa051600.55028097
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54675659
129Tuberculosis_Homo sapiens_hsa051520.54217161
130Gap junction_Homo sapiens_hsa045400.53301665
131HIF-1 signaling pathway_Homo sapiens_hsa040660.52143319

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