EZH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.18770855
2protein localization to kinetochore (GO:0034501)5.09985572
3mitotic metaphase plate congression (GO:0007080)4.74923160
4DNA replication initiation (GO:0006270)4.60099066
5kinetochore organization (GO:0051383)4.57502298
6DNA strand elongation involved in DNA replication (GO:0006271)4.56709380
7mitotic chromosome condensation (GO:0007076)4.53750971
8protein localization to chromosome, centromeric region (GO:0071459)4.48313250
9attachment of spindle microtubules to kinetochore (GO:0008608)4.41123411
10DNA strand elongation (GO:0022616)4.37917621
11mitotic sister chromatid segregation (GO:0000070)4.31441513
12CENP-A containing nucleosome assembly (GO:0034080)4.27748181
13metaphase plate congression (GO:0051310)4.26951793
14chromatin remodeling at centromere (GO:0031055)4.22929826
15sister chromatid segregation (GO:0000819)4.21823866
16mitotic sister chromatid cohesion (GO:0007064)4.16512348
17telomere maintenance via semi-conservative replication (GO:0032201)4.16351364
18DNA replication checkpoint (GO:0000076)4.13392344
19DNA replication-independent nucleosome organization (GO:0034724)4.12943416
20DNA replication-independent nucleosome assembly (GO:0006336)4.12943416
21mitotic recombination (GO:0006312)4.03763225
22kinetochore assembly (GO:0051382)4.00667770
23establishment of integrated proviral latency (GO:0075713)3.99330012
24telomere maintenance via recombination (GO:0000722)3.97219945
25DNA replication-dependent nucleosome organization (GO:0034723)3.95715602
26DNA replication-dependent nucleosome assembly (GO:0006335)3.95715602
27nuclear pore organization (GO:0006999)3.89591959
28establishment of chromosome localization (GO:0051303)3.89300264
29nuclear pore complex assembly (GO:0051292)3.88882633
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.87197847
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.86348593
32meiotic chromosome segregation (GO:0045132)3.83717323
33mitotic nuclear envelope disassembly (GO:0007077)3.81831733
34histone exchange (GO:0043486)3.74251198
35regulation of sister chromatid cohesion (GO:0007063)3.69067300
36positive regulation of chromosome segregation (GO:0051984)3.64667563
37regulation of spindle organization (GO:0090224)3.63754435
38replication fork processing (GO:0031297)3.62999767
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.56784369
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.56139815
41chromatin assembly or disassembly (GO:0006333)3.55690697
42telomere maintenance via telomere lengthening (GO:0010833)3.52606436
43membrane disassembly (GO:0030397)3.50716503
44nuclear envelope disassembly (GO:0051081)3.50716503
45double-strand break repair via nonhomologous end joining (GO:0006303)3.49410630
46non-recombinational repair (GO:0000726)3.49410630
47spindle checkpoint (GO:0031577)3.47454117
48ATP-dependent chromatin remodeling (GO:0043044)3.47056518
49negative regulation of mRNA processing (GO:0050686)3.43284877
50regulation of chromosome segregation (GO:0051983)3.42106054
51heterochromatin organization (GO:0070828)3.41996508
52DNA duplex unwinding (GO:0032508)3.38992639
53DNA geometric change (GO:0032392)3.37001596
54regulation of histone H3-K9 methylation (GO:0051570)3.36815331
55DNA topological change (GO:0006265)3.36619598
56* protein localization to chromosome (GO:0034502)3.33962956
57chromosome segregation (GO:0007059)3.33772527
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.31533158
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31533158
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31533158
61regulation of DNA endoreduplication (GO:0032875)3.29764831
62regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28953947
63purine nucleobase biosynthetic process (GO:0009113)3.28197725
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27854027
65mismatch repair (GO:0006298)3.26903285
66negative regulation of chromosome segregation (GO:0051985)3.26859239
67protein K6-linked ubiquitination (GO:0085020)3.26575744
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25788683
69spindle assembly checkpoint (GO:0071173)3.24734285
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.24259536
71negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24259536
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24259536
73negative regulation of sister chromatid segregation (GO:0033046)3.24259536
74DNA double-strand break processing (GO:0000729)3.22286323
75folic acid-containing compound biosynthetic process (GO:0009396)3.21294220
76mitotic spindle checkpoint (GO:0071174)3.20544266
77negative regulation of histone methylation (GO:0031061)3.16778422
78mitotic spindle assembly checkpoint (GO:0007094)3.15599887
79V(D)J recombination (GO:0033151)3.15020078
80DNA replication (GO:0006260)3.14680355
81chromosome condensation (GO:0030261)3.13865586
82ribosomal small subunit assembly (GO:0000028)3.13406251
83regulation of sister chromatid segregation (GO:0033045)3.12897759
84regulation of mitotic sister chromatid separation (GO:0010965)3.12897759
85regulation of mitotic sister chromatid segregation (GO:0033047)3.12897759
86microtubule depolymerization (GO:0007019)3.12400854
87maturation of SSU-rRNA (GO:0030490)3.11438033
88DNA conformation change (GO:0071103)3.10236552
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.08861014
90resolution of meiotic recombination intermediates (GO:0000712)3.08681047
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07806826
92somatic hypermutation of immunoglobulin genes (GO:0016446)3.07806826
93establishment of viral latency (GO:0019043)3.06430453
94regulation of centrosome cycle (GO:0046605)3.06344071
95viral mRNA export from host cell nucleus (GO:0046784)3.05982431
96regulation of mitotic spindle organization (GO:0060236)3.05846301
97regulation of centriole replication (GO:0046599)3.05250320
98regulation of nuclear cell cycle DNA replication (GO:0033262)3.04866224
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03627190
100centriole replication (GO:0007099)3.02446442
101translesion synthesis (GO:0019985)3.01498134
102negative regulation of mRNA metabolic process (GO:1903312)3.01294689
103pore complex assembly (GO:0046931)3.00724043
104telomere maintenance (GO:0000723)2.97804837
105formation of translation preinitiation complex (GO:0001731)2.96734409
106chromosome organization (GO:0051276)2.96693065
107nucleobase biosynthetic process (GO:0046112)2.96067266
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95495837
109telomere organization (GO:0032200)2.94960270
110DNA packaging (GO:0006323)2.92734737
111DNA ligation (GO:0006266)2.91744630
112negative regulation of RNA splicing (GO:0033119)2.87225413
113mitotic cell cycle (GO:0000278)2.84892608
114IMP biosynthetic process (GO:0006188)2.84592381
115DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.81552406
116chromatin assembly (GO:0031497)2.80717350
117DNA damage response, signal transduction resulting in transcription (GO:0042772)2.78193610
118DNA synthesis involved in DNA repair (GO:0000731)2.77749593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.05696521
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.82399332
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.11389674
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.71365585
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72467288
6AR_21909140_ChIP-Seq_LNCAP_Human2.67926916
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65660577
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53749854
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50264885
10* E2F1_21310950_ChIP-Seq_MCF-7_Human2.45310427
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40555316
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38646089
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.36603352
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.36158711
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24844364
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.20820241
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15364836
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13845800
19XRN2_22483619_ChIP-Seq_HELA_Human2.08812177
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05151373
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.04749214
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02935736
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01937040
24E2F7_22180533_ChIP-Seq_HELA_Human11.6157795
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98216693
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.96280605
27MYC_22102868_ChIP-Seq_BL_Human1.94762823
28VDR_23849224_ChIP-Seq_CD4+_Human1.91190161
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90984819
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84687384
31FOXP3_21729870_ChIP-Seq_TREG_Human1.84227091
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83447568
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.78292102
34CIITA_25753668_ChIP-Seq_RAJI_Human1.76330479
35* TTF2_22483619_ChIP-Seq_HELA_Human1.70034537
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62586732
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60547340
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58251249
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55173587
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54678210
41* DCP1A_22483619_ChIP-Seq_HELA_Human1.52986968
42ELK1_19687146_ChIP-ChIP_HELA_Human1.48981597
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48855583
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47247259
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45939756
46* GABP_19822575_ChIP-Seq_HepG2_Human1.45095216
47KDM5A_27292631_Chip-Seq_BREAST_Human1.42773376
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41323382
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41040514
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40939855
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39114817
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33694484
53* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32401306
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29482927
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28810544
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28566917
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28403474
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28261437
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18713491
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17092693
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15577040
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15221409
63MYC_18940864_ChIP-ChIP_HL60_Human1.15065078
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11867911
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11067935
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08795348
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08661390
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06619753
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04390611
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04334160
71VDR_21846776_ChIP-Seq_THP-1_Human1.03249278
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03209362
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.01059808
74YY1_21170310_ChIP-Seq_MESCs_Mouse0.97475442
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97458333
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95367769
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90668168
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89744056
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89247179
80EWS_26573619_Chip-Seq_HEK293_Human0.88499681
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88066062
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87941648
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87094554
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86580737
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81127514
86IRF1_19129219_ChIP-ChIP_H3396_Human0.80388365
87TFEB_21752829_ChIP-Seq_HELA_Human0.79445716
88SPI1_23547873_ChIP-Seq_NB4_Human0.78669709
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.78579758
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77645861
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76839226
92* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75654974
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75091152
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.73247534
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73019995
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.72732938
97* SRF_21415370_ChIP-Seq_HL-1_Mouse0.70952371
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.70109431
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70056914
100* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68483504
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.68095073
102CHD1_26751641_Chip-Seq_LNCaP_Human0.67825316
103TCF3_18692474_ChIP-Seq_MESCs_Mouse0.66900141
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66626763
105* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65277821
106* UTX_26944678_Chip-Seq_JUKART_Human0.65277440
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.65273582
108PKCTHETA_26484144_Chip-Seq_BREAST_Human0.64545494
109FUS_26573619_Chip-Seq_HEK293_Human0.62579823
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.62277739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.84030193
2MP0003693_abnormal_embryo_hatching4.61995712
3MP0003111_abnormal_nucleus_morphology4.32599865
4MP0008057_abnormal_DNA_replication4.26298517
5MP0003077_abnormal_cell_cycle3.90882759
6MP0004957_abnormal_blastocyst_morpholog3.74777282
7MP0008058_abnormal_DNA_repair3.14438915
8MP0008007_abnormal_cellular_replicative2.68513316
9MP0009697_abnormal_copulation2.58080879
10MP0002396_abnormal_hematopoietic_system2.46064568
11MP0003123_paternal_imprinting2.35301185
12* MP0008932_abnormal_embryonic_tissue2.35065436
13MP0008877_abnormal_DNA_methylation2.30860725
14MP0000350_abnormal_cell_proliferation2.15316188
15MP0001730_embryonic_growth_arrest2.03219553
16MP0003121_genomic_imprinting1.98995846
17MP0010307_abnormal_tumor_latency1.77478025
18MP0008995_early_reproductive_senescence1.73926254
19MP0006292_abnormal_olfactory_placode1.72596755
20MP0010352_gastrointestinal_tract_polyps1.70864657
21* MP0005380_embryogenesis_phenotype1.67396017
22* MP0001672_abnormal_embryogenesis/_devel1.67396017
23MP0000490_abnormal_crypts_of1.65993301
24* MP0002085_abnormal_embryonic_tissue1.63638629
25* MP0001697_abnormal_embryo_size1.61707556
26MP0004808_abnormal_hematopoietic_stem1.58228650
27MP0003786_premature_aging1.50745568
28* MP0002084_abnormal_developmental_patter1.50484027
29MP0002102_abnormal_ear_morphology1.50347312
30MP0003718_maternal_effect1.48775083
31* MP0003984_embryonic_growth_retardation1.48047430
32* MP0002088_abnormal_embryonic_growth/wei1.44268406
33MP0004197_abnormal_fetal_growth/weight/1.40814178
34MP0000537_abnormal_urethra_morphology1.38604009
35MP0010030_abnormal_orbit_morphology1.37936729
36MP0003937_abnormal_limbs/digits/tail_de1.37844269
37* MP0002080_prenatal_lethality1.37232651
38MP0003567_abnormal_fetal_cardiomyocyte1.35208315
39MP0003890_abnormal_embryonic-extraembry1.35175718
40MP0002019_abnormal_tumor_incidence1.34462598
41MP0001293_anophthalmia1.34135687
42MP0003787_abnormal_imprinting1.33740916
43MP0003763_abnormal_thymus_physiology1.33129465
44MP0002210_abnormal_sex_determination1.32068041
45MP0001346_abnormal_lacrimal_gland1.28858382
46MP0000313_abnormal_cell_death1.28668176
47* MP0002086_abnormal_extraembryonic_tissu1.27993418
48MP0004147_increased_porphyrin_level1.25527682
49MP0003315_abnormal_perineum_morphology1.23819236
50MP0005076_abnormal_cell_differentiation1.23025625
51MP0000703_abnormal_thymus_morphology1.21501400
52MP0001145_abnormal_male_reproductive1.10994537
53MP0006035_abnormal_mitochondrial_morpho1.09525719
54MP0001929_abnormal_gametogenesis1.07275180
55MP0001529_abnormal_vocalization1.07250620
56MP0000566_synostosis1.06850923
57MP0000653_abnormal_sex_gland1.05108280
58MP0002009_preneoplasia1.04362820
59* MP0002398_abnormal_bone_marrow1.03842647
60MP0001119_abnormal_female_reproductive1.03782668
61MP0002938_white_spotting1.03522997
62MP0008789_abnormal_olfactory_epithelium1.03477192
63MP0009053_abnormal_anal_canal1.03315188
64MP0000358_abnormal_cell_content/1.02809537
65MP0005397_hematopoietic_system_phenotyp0.99475986
66MP0001545_abnormal_hematopoietic_system0.99475986
67MP0009333_abnormal_splenocyte_physiolog0.97707396
68MP0009278_abnormal_bone_marrow0.94943191
69MP0001286_abnormal_eye_development0.94686850
70MP0000647_abnormal_sebaceous_gland0.94585137
71MP0009672_abnormal_birth_weight0.94100875
72MP0006072_abnormal_retinal_apoptosis0.90900226
73MP0002722_abnormal_immune_system0.88536926
74MP0003698_abnormal_male_reproductive0.87740414
75MP0000778_abnormal_nervous_system0.86697848
76MP0005391_vision/eye_phenotype0.86464033
77MP0003941_abnormal_skin_development0.86360397
78MP0002111_abnormal_tail_morphology0.85508782
79MP0009703_decreased_birth_body0.85490017
80MP0000428_abnormal_craniofacial_morphol0.85253573
81MP0003938_abnormal_ear_development0.83742051
82MP0000689_abnormal_spleen_morphology0.83322190
83MP0003942_abnormal_urinary_system0.82984483
84MP0002653_abnormal_ependyma_morphology0.82778704
85MP0002092_abnormal_eye_morphology0.82578396
86MP0000432_abnormal_head_morphology0.82166867
87MP0003119_abnormal_digestive_system0.80239019
88MP0000631_abnormal_neuroendocrine_gland0.79667349
89MP0001915_intracranial_hemorrhage0.79463749
90MP0003935_abnormal_craniofacial_develop0.79060228
91MP0003385_abnormal_body_wall0.78640513
92MP0003755_abnormal_palate_morphology0.78462046
93MP0000569_abnormal_digit_pigmentation0.75318506
94MP0000049_abnormal_middle_ear0.75165335
95MP0006054_spinal_hemorrhage0.74232118
96MP0002249_abnormal_larynx_morphology0.74123912
97MP0000383_abnormal_hair_follicle0.73995024
98MP0000372_irregular_coat_pigmentation0.73775924
99* MP0003861_abnormal_nervous_system0.73320137
100MP0002932_abnormal_joint_morphology0.73130031
101MP0002161_abnormal_fertility/fecundity0.71287458
102* MP0002429_abnormal_blood_cell0.71020289
103MP0002095_abnormal_skin_pigmentation0.70718535
104MP0002081_perinatal_lethality0.68863431
105MP0003943_abnormal_hepatobiliary_system0.68583595
106MP0003115_abnormal_respiratory_system0.68212500
107MP0002751_abnormal_autonomic_nervous0.67210453
108MP0005187_abnormal_penis_morphology0.67182037
109MP0002160_abnormal_reproductive_system0.66837547
110MP0001727_abnormal_embryo_implantation0.66781519
111MP0002234_abnormal_pharynx_morphology0.66281107
112MP0003806_abnormal_nucleotide_metabolis0.65962382
113MP0003136_yellow_coat_color0.65862101
114MP0003699_abnormal_female_reproductive0.65612765
115MP0000733_abnormal_muscle_development0.65285638
116MP0002114_abnormal_axial_skeleton0.64651840
117MP0000477_abnormal_intestine_morphology0.64314721
118MP0002116_abnormal_craniofacial_bone0.63778568
119MP0005499_abnormal_olfactory_system0.63329101
120MP0005394_taste/olfaction_phenotype0.63329101
121MP0001849_ear_inflammation0.62914719
122MP0003221_abnormal_cardiomyocyte_apopto0.62913323
123MP0002697_abnormal_eye_size0.62664599
124* MP0000716_abnormal_immune_system0.62646398
125MP0005384_cellular_phenotype0.62514328
126MP0009250_abnormal_appendicular_skeleto0.62482391
127MP0002233_abnormal_nose_morphology0.62197375

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.63310694
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.37230021
3Birth length less than 3rd percentile (HP:0003561)4.31857287
4Patellar aplasia (HP:0006443)3.58587956
5Abnormality of chromosome stability (HP:0003220)3.50362020
6Cortical dysplasia (HP:0002539)3.45066714
7Reticulocytopenia (HP:0001896)3.43710385
8Volvulus (HP:0002580)3.39098008
9Medulloblastoma (HP:0002885)3.38733497
10Aplasia/Hypoplasia of the patella (HP:0006498)3.35022380
11Meckel diverticulum (HP:0002245)3.26134532
12Abnormality of cochlea (HP:0000375)3.21438692
13Ectopic kidney (HP:0000086)3.20224578
14Abnormality of the preputium (HP:0100587)3.18468650
15Breast hypoplasia (HP:0003187)3.17968636
16Abnormality of the ileum (HP:0001549)3.15304410
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.15049506
18Colon cancer (HP:0003003)3.05794253
19Small intestinal stenosis (HP:0012848)2.84158120
20Duodenal stenosis (HP:0100867)2.84158120
21Increased nuchal translucency (HP:0010880)2.82619203
22Impulsivity (HP:0100710)2.78432109
23Myelodysplasia (HP:0002863)2.75959824
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69025907
25Short 4th metacarpal (HP:0010044)2.69025907
26Nephroblastoma (Wilms tumor) (HP:0002667)2.67489240
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64804583
28Abnormal lung lobation (HP:0002101)2.64036097
29Ependymoma (HP:0002888)2.62579256
30High anterior hairline (HP:0009890)2.61826963
31Rhabdomyosarcoma (HP:0002859)2.60778266
32Abnormality of the labia minora (HP:0012880)2.60496162
33Morphological abnormality of the inner ear (HP:0011390)2.57427165
34Selective tooth agenesis (HP:0001592)2.51606684
35Abnormal number of incisors (HP:0011064)2.50064163
36Embryonal renal neoplasm (HP:0011794)2.47585062
37Absent radius (HP:0003974)2.41798000
38Oral leukoplakia (HP:0002745)2.40395548
39Supernumerary spleens (HP:0009799)2.39955431
40Sloping forehead (HP:0000340)2.39100103
41Abnormality of cells of the erythroid lineage (HP:0012130)2.38719815
42Abnormality of the carotid arteries (HP:0005344)2.37442110
43Proximal placement of thumb (HP:0009623)2.36835760
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.36304282
45Atresia of the external auditory canal (HP:0000413)2.35447169
46Absent forearm bone (HP:0003953)2.34606905
47Aplasia involving forearm bones (HP:0009822)2.34606905
48Abnormality of the duodenum (HP:0002246)2.32731838
49Duplicated collecting system (HP:0000081)2.27386731
50Abnormal number of erythroid precursors (HP:0012131)2.27300735
51Aplastic anemia (HP:0001915)2.27222055
52Deviation of the thumb (HP:0009603)2.27108873
53Absent thumb (HP:0009777)2.24219778
54Short thumb (HP:0009778)2.23316302
55Bone marrow hypocellularity (HP:0005528)2.20180104
56Facial hemangioma (HP:0000329)2.18449599
57Microvesicular hepatic steatosis (HP:0001414)2.15285008
58Triphalangeal thumb (HP:0001199)2.11697319
59Abnormality of the renal collecting system (HP:0004742)2.11432597
60Agnosia (HP:0010524)2.09569906
61Neoplasm of striated muscle (HP:0009728)2.07727067
62Clubbing of toes (HP:0100760)2.07545380
63Abnormality of DNA repair (HP:0003254)2.06197793
64Tracheoesophageal fistula (HP:0002575)2.05085895
65Abnormality of reticulocytes (HP:0004312)2.04544200
66Duplication of thumb phalanx (HP:0009942)2.03854215
67Neoplasm of the pancreas (HP:0002894)2.02935785
68Cafe-au-lait spot (HP:0000957)2.02904819
69Carpal bone hypoplasia (HP:0001498)2.02390722
70Long eyelashes (HP:0000527)2.01031875
71Basal cell carcinoma (HP:0002671)1.99639333
72Abnormality of the anterior horn cell (HP:0006802)1.99368354
73Degeneration of anterior horn cells (HP:0002398)1.99368354
74Horseshoe kidney (HP:0000085)1.93986498
75Acute myeloid leukemia (HP:0004808)1.93862703
76Oligodactyly (HP:0012165)1.87871851
77Neoplasm of the oral cavity (HP:0100649)1.86112899
78Premature graying of hair (HP:0002216)1.85774334
7911 pairs of ribs (HP:0000878)1.85184807
80High pitched voice (HP:0001620)1.84062062
81Broad distal phalanx of finger (HP:0009836)1.84017585
82Facial cleft (HP:0002006)1.83046752
83Pallor (HP:0000980)1.82887059
84Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82109588
85Acute lymphatic leukemia (HP:0006721)1.82069449
86Prominent nose (HP:0000448)1.81867279
87Abnormality of the 4th metacarpal (HP:0010012)1.80248762
88Microtia (HP:0008551)1.79823775
89Embryonal neoplasm (HP:0002898)1.79435389
90Abnormality of the intervertebral disk (HP:0005108)1.78434244
91Supernumerary bones of the axial skeleton (HP:0009144)1.77866884
92Optic nerve coloboma (HP:0000588)1.77728238
93Hypoplasia of the pons (HP:0012110)1.77576669
94Absent epiphyses (HP:0010577)1.77098443
95Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77098443
96Cellular immunodeficiency (HP:0005374)1.76934822
97Cutis marmorata (HP:0000965)1.76017594
98Rib fusion (HP:0000902)1.76006757
99Obsessive-compulsive behavior (HP:0000722)1.75888880
100Oligodactyly (hands) (HP:0001180)1.75723436
101Irregular epiphyses (HP:0010582)1.75675591
102Neoplasm of the colon (HP:0100273)1.75210484
103Squamous cell carcinoma (HP:0002860)1.75098687
104Lymphoma (HP:0002665)1.74618931
105Gastrointestinal carcinoma (HP:0002672)1.74601607
106Malignant gastrointestinal tract tumors (HP:0006749)1.74601607
107Combined immunodeficiency (HP:0005387)1.73503580
108Abnormality of the astrocytes (HP:0100707)1.72450662
109Astrocytoma (HP:0009592)1.72450662
110Glioma (HP:0009733)1.72099896
111Aplasia/Hypoplasia of the earlobes (HP:0009906)1.71153989
112Macrocytic anemia (HP:0001972)1.69907983
113Pancytopenia (HP:0001876)1.69220043
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69065474
115Preaxial hand polydactyly (HP:0001177)1.68234667
116Amaurosis fugax (HP:0100576)1.68005964
117Holoprosencephaly (HP:0001360)1.67019547
118Supernumerary ribs (HP:0005815)1.66924616
119Abnormality of chromosome segregation (HP:0002916)1.66463435
120Biliary tract neoplasm (HP:0100574)1.66123011
121Abnormality of the pons (HP:0007361)1.66034504
122Missing ribs (HP:0000921)1.64982154
123Choanal atresia (HP:0000453)1.64655442
124Arteriovenous malformation (HP:0100026)1.64461754
125Hemivertebrae (HP:0002937)1.63643295
126Rough bone trabeculation (HP:0100670)1.63123293
127Deep palmar crease (HP:0006191)1.62896106
128Abnormality of glycolysis (HP:0004366)1.61236753
129Long clavicles (HP:0000890)1.61049603
130Tetralogy of Fallot (HP:0001636)1.60154345
131Overriding aorta (HP:0002623)1.59142130
132Trigonocephaly (HP:0000243)1.56651115
133Dandy-Walker malformation (HP:0001305)1.54887152
134Hypoplastic pelvis (HP:0008839)1.53252429
135Increased serum pyruvate (HP:0003542)1.51151156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.19408834
2WEE13.71208235
3NEK23.64669395
4BUB13.61108904
5PLK42.91023826
6TTK2.87618186
7NEK12.79997270
8SRPK12.78903208
9MKNK12.38178021
10VRK22.28184116
11EEF2K2.20901949
12CDK122.16515365
13PLK12.05468061
14MAP3K102.02960750
15BRSK21.96116074
16ATR1.91182391
17AURKB1.90155764
18EIF2AK11.87920744
19PASK1.87907904
20MKNK21.86566320
21CDK71.82773701
22CHEK21.79628532
23ACVR1B1.79076204
24DYRK31.65380909
25PLK31.62570426
26CDK41.57238735
27RPS6KB21.52775308
28STK101.52509600
29STK41.46183795
30TAF11.45929616
31CHEK11.44681357
32TSSK61.42618624
33RPS6KA41.38081287
34VRK11.35843854
35BRD41.33002120
36TLK11.32026676
37MAP3K81.29520753
38MELK1.23315909
39ICK1.22058386
40CCNB11.20480052
41BRSK11.18219651
42TGFBR11.16836456
43AURKA1.15000703
44ATM1.14251840
45LATS11.13647208
46CDK81.11598039
47CLK11.10314617
48NME11.08822164
49SMG11.08774432
50EIF2AK31.08685959
51STK30.98935285
52* CDK20.97571214
53PIM10.91792745
54CDK60.91250317
55BCR0.89972173
56STK160.87418417
57MAP4K10.85699362
58NME20.85635300
59* CDK10.84140174
60CDK90.73239021
61CAMK1G0.72485011
62EIF2AK20.70747685
63ZAK0.70384926
64MAP3K60.68836699
65BRAF0.66858040
66TESK20.65218129
67MAP3K40.64999830
68PNCK0.62660538
69CAMK1D0.59774756
70DYRK20.57001945
71NUAK10.55377125
72TRIM280.54422181
73CSNK2A20.53985194
74CSNK2A10.53695250
75STK38L0.52126017
76PAK40.51700968
77CDK11A0.51516958
78BTK0.50198753
79BMPR1B0.49971658
80CDK150.49141514
81CDK180.48863655
82ALK0.48174177
83PAK10.45789031
84RPS6KA50.45188541
85CDK140.44691389
86MTOR0.44276403
87NLK0.43936320
88TNIK0.43930496
89SCYL20.41235700
90PRKDC0.40068614
91JAK30.39777723
92CSNK1D0.39680706
93DMPK0.38396383
94YES10.38091197
95LATS20.37574050
96KSR10.37332192
97LRRK20.37237540
98PLK20.37215745
99* MAPK140.35356377
100CSNK1G10.35315290
101PBK0.33378107
102MST40.33358340
103CHUK0.33226478
104CSNK1E0.33176055
105PRKCI0.32380232
106EPHA20.32266103
107MAP2K30.31642756
108SIK20.30774571
109CSNK1G30.30752307
110* AKT10.29546921
111CASK0.28481398
112IRAK30.28324029
113GSK3B0.26832399
114MAP2K70.26097136
115AKT20.26096532
116CDK30.25901382
117CSNK1A1L0.25373524
118MARK30.25045525
119RAF10.24500913
120TEC0.23940772
121MAPK10.23831915
122FGFR10.23135796
123CSF1R0.23035320
124CSNK1G20.22937697
125WNK30.22691959
126RPS6KB10.21663212
127PKN20.21058607
128RPS6KA10.18205774

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.98552954
2Mismatch repair_Homo sapiens_hsa034304.31448693
3Cell cycle_Homo sapiens_hsa041103.43759554
4Homologous recombination_Homo sapiens_hsa034403.26560319
5Base excision repair_Homo sapiens_hsa034103.21588689
6Spliceosome_Homo sapiens_hsa030403.21003606
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98227458
8RNA transport_Homo sapiens_hsa030132.97753289
9Nucleotide excision repair_Homo sapiens_hsa034202.78866864
10Fanconi anemia pathway_Homo sapiens_hsa034602.75409573
11Non-homologous end-joining_Homo sapiens_hsa034502.65225393
12RNA polymerase_Homo sapiens_hsa030202.51842215
13Ribosome_Homo sapiens_hsa030102.47907996
14One carbon pool by folate_Homo sapiens_hsa006702.22022632
15RNA degradation_Homo sapiens_hsa030182.18276502
16mRNA surveillance pathway_Homo sapiens_hsa030152.15738260
17Basal transcription factors_Homo sapiens_hsa030222.05891319
18Pyrimidine metabolism_Homo sapiens_hsa002402.05169020
19p53 signaling pathway_Homo sapiens_hsa041151.78431730
20Proteasome_Homo sapiens_hsa030501.73856502
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73148888
22Protein export_Homo sapiens_hsa030601.43323268
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33809575
24Systemic lupus erythematosus_Homo sapiens_hsa053221.28246275
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24033274
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19023405
27Epstein-Barr virus infection_Homo sapiens_hsa051691.17244898
28* MicroRNAs in cancer_Homo sapiens_hsa052061.15846338
29Oocyte meiosis_Homo sapiens_hsa041141.15675364
30Herpes simplex infection_Homo sapiens_hsa051681.14565302
31Biosynthesis of amino acids_Homo sapiens_hsa012301.13510634
32Viral carcinogenesis_Homo sapiens_hsa052031.09794273
33Primary immunodeficiency_Homo sapiens_hsa053401.09468751
34Steroid biosynthesis_Homo sapiens_hsa001001.08179677
35Purine metabolism_Homo sapiens_hsa002301.07975268
36HTLV-I infection_Homo sapiens_hsa051661.01539151
37Huntingtons disease_Homo sapiens_hsa050160.94492521
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92616915
39Small cell lung cancer_Homo sapiens_hsa052220.91642500
40Parkinsons disease_Homo sapiens_hsa050120.91612395
41Colorectal cancer_Homo sapiens_hsa052100.87767749
42Basal cell carcinoma_Homo sapiens_hsa052170.85164276
43Chronic myeloid leukemia_Homo sapiens_hsa052200.83128343
44Oxidative phosphorylation_Homo sapiens_hsa001900.81956806
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80418915
46Antigen processing and presentation_Homo sapiens_hsa046120.80392251
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77745959
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77100009
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75655619
50TGF-beta signaling pathway_Homo sapiens_hsa043500.75644875
51Thyroid cancer_Homo sapiens_hsa052160.72580365
52Folate biosynthesis_Homo sapiens_hsa007900.72312251
53Notch signaling pathway_Homo sapiens_hsa043300.71520376
54Hippo signaling pathway_Homo sapiens_hsa043900.69785964
55Carbon metabolism_Homo sapiens_hsa012000.69741855
56Pyruvate metabolism_Homo sapiens_hsa006200.67506569
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.65668282
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63832732
59Hepatitis B_Homo sapiens_hsa051610.63029971
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62298536
61Pancreatic cancer_Homo sapiens_hsa052120.61780463
62Measles_Homo sapiens_hsa051620.61777511
63Prostate cancer_Homo sapiens_hsa052150.60783025
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60597529
65Sulfur relay system_Homo sapiens_hsa041220.59281606
66Hedgehog signaling pathway_Homo sapiens_hsa043400.57152563
67Non-small cell lung cancer_Homo sapiens_hsa052230.56848488
68Propanoate metabolism_Homo sapiens_hsa006400.55480539
69Alcoholism_Homo sapiens_hsa050340.55002597
70Apoptosis_Homo sapiens_hsa042100.53160728
71Pathways in cancer_Homo sapiens_hsa052000.50759348
72Viral myocarditis_Homo sapiens_hsa054160.50613074
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49706573
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49138735
75Wnt signaling pathway_Homo sapiens_hsa043100.47588725
76Adherens junction_Homo sapiens_hsa045200.47254063
77Lysine degradation_Homo sapiens_hsa003100.46387461
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45637211
79B cell receptor signaling pathway_Homo sapiens_hsa046620.43246570
80Hematopoietic cell lineage_Homo sapiens_hsa046400.42955883
81Endometrial cancer_Homo sapiens_hsa052130.42426112
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41187970
83FoxO signaling pathway_Homo sapiens_hsa040680.40815876
84Acute myeloid leukemia_Homo sapiens_hsa052210.39787050
85Selenocompound metabolism_Homo sapiens_hsa004500.39156239
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.38394718
87Pentose phosphate pathway_Homo sapiens_hsa000300.38391685
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37954752
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37785783
90Vitamin B6 metabolism_Homo sapiens_hsa007500.37433045
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36986006
92Influenza A_Homo sapiens_hsa051640.36379041
93T cell receptor signaling pathway_Homo sapiens_hsa046600.35904280
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35648580
95Shigellosis_Homo sapiens_hsa051310.35029427
96Legionellosis_Homo sapiens_hsa051340.33714601
97Melanoma_Homo sapiens_hsa052180.31427092
98Alzheimers disease_Homo sapiens_hsa050100.31252446
99mTOR signaling pathway_Homo sapiens_hsa041500.30849182
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.30155254
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30062071
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29679065
103Bladder cancer_Homo sapiens_hsa052190.29613197
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.29607782
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27942314
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.27673984
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27519716
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27503457
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27255068
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.25401077
111Metabolic pathways_Homo sapiens_hsa011000.25037059
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23563294
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23025453
114Fatty acid elongation_Homo sapiens_hsa000620.22681065
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.22533776
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.22381537
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21421419
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20676146
119Proteoglycans in cancer_Homo sapiens_hsa052050.19353088
120Allograft rejection_Homo sapiens_hsa053300.18994034
121Glutathione metabolism_Homo sapiens_hsa004800.18298912
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17869496
123Asthma_Homo sapiens_hsa053100.17226869
124HIF-1 signaling pathway_Homo sapiens_hsa040660.16995452
125Toxoplasmosis_Homo sapiens_hsa051450.16742729
126Tight junction_Homo sapiens_hsa045300.16273424
127Autoimmune thyroid disease_Homo sapiens_hsa053200.15792413
128Prolactin signaling pathway_Homo sapiens_hsa049170.15584674
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15234451
130N-Glycan biosynthesis_Homo sapiens_hsa005100.14075523
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.12976794
132Fructose and mannose metabolism_Homo sapiens_hsa000510.09529970
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08829787
134Fatty acid metabolism_Homo sapiens_hsa012120.08688757
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08335968

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