EZH2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.49409333
2translational termination (GO:0006415)8.24574349
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.98153979
4ATP synthesis coupled proton transport (GO:0015986)7.30940061
5energy coupled proton transport, down electrochemical gradient (GO:0015985)7.30940061
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.00929530
7ribosomal small subunit assembly (GO:0000028)6.98126001
8cotranslational protein targeting to membrane (GO:0006613)6.95954724
9protein targeting to ER (GO:0045047)6.81123096
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.52565432
11maturation of SSU-rRNA (GO:0030490)6.46958624
12translational elongation (GO:0006414)6.43196458
13cellular protein complex disassembly (GO:0043624)6.41814347
14protein localization to endoplasmic reticulum (GO:0070972)6.31952250
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.03500750
16viral life cycle (GO:0019058)5.95385959
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.76787803
18protein complex disassembly (GO:0043241)5.60588869
19ribosomal small subunit biogenesis (GO:0042274)5.59574179
20establishment of protein localization to mitochondrial membrane (GO:0090151)5.52088079
21macromolecular complex disassembly (GO:0032984)5.39826006
22epithelial cilium movement (GO:0003351)5.36592806
23translational initiation (GO:0006413)5.24926522
24neuron fate determination (GO:0048664)5.10668784
25response to pheromone (GO:0019236)4.51655462
26protein targeting to membrane (GO:0006612)4.46063350
27inner mitochondrial membrane organization (GO:0007007)4.34152696
28epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.26943914
29electron transport chain (GO:0022900)4.25139214
30respiratory electron transport chain (GO:0022904)4.24687776
31ATP biosynthetic process (GO:0006754)4.22748571
32nuclear-transcribed mRNA catabolic process (GO:0000956)4.19132734
33cilium movement (GO:0003341)4.17502783
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13214946
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.06675394
36purine nucleoside triphosphate biosynthetic process (GO:0009145)4.01967114
37axonemal dynein complex assembly (GO:0070286)3.98142029
38mRNA catabolic process (GO:0006402)3.96116031
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92225787
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.92225787
41NADH dehydrogenase complex assembly (GO:0010257)3.92225787
42translation (GO:0006412)3.81293140
43astrocyte differentiation (GO:0048708)3.61695174
44GTP biosynthetic process (GO:0006183)3.55777001
45ribonucleoside triphosphate biosynthetic process (GO:0009201)3.51445400
46chaperone-mediated protein transport (GO:0072321)3.49264014
47RNA catabolic process (GO:0006401)3.48911754
48neuronal stem cell maintenance (GO:0097150)3.39366878
49establishment of planar polarity (GO:0001736)3.35440552
50establishment of tissue polarity (GO:0007164)3.35440552
51hydrogen ion transmembrane transport (GO:1902600)3.32597952
52protein localization to cilium (GO:0061512)3.32439239
53centriole replication (GO:0007099)3.30654153
54protein complex biogenesis (GO:0070271)3.30315662
55proton transport (GO:0015992)3.25414943
56hydrogen transport (GO:0006818)3.20534726
57protein neddylation (GO:0045116)3.12065716
58establishment of protein localization to membrane (GO:0090150)3.05689353
59ribosomal large subunit biogenesis (GO:0042273)3.04761849
60spinal cord development (GO:0021510)3.00530711
61nucleoside triphosphate biosynthetic process (GO:0009142)2.93915246
62mitochondrial respiratory chain complex assembly (GO:0033108)2.91680374
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91211398
64UTP biosynthetic process (GO:0006228)2.90482448
65endocardial cushion morphogenesis (GO:0003203)2.90007348
66negative regulation of transcription regulatory region DNA binding (GO:2000678)2.89252869
67cellular respiration (GO:0045333)2.87490450
68spermatid nucleus differentiation (GO:0007289)2.83289277
69sequestering of actin monomers (GO:0042989)2.82123194
70regulation of timing of cell differentiation (GO:0048505)2.78246949
71termination of RNA polymerase III transcription (GO:0006386)2.78077651
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.78077651
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77573042
74somite development (GO:0061053)2.76669743
75behavioral response to nicotine (GO:0035095)2.75160457
76UTP metabolic process (GO:0046051)2.74698682
77protein targeting (GO:0006605)2.74323107
78positive regulation of respiratory burst (GO:0060267)2.73393393
79dendritic spine morphogenesis (GO:0060997)2.72877575
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.71343383
81retina vasculature morphogenesis in camera-type eye (GO:0061299)2.70897899
82oxidative phosphorylation (GO:0006119)2.70616671
83establishment of protein localization to organelle (GO:0072594)2.68503897
84ribonucleoprotein complex disassembly (GO:0032988)2.67832503
85cell proliferation in forebrain (GO:0021846)2.65249049
86negative regulation of B cell apoptotic process (GO:0002903)2.64036029
87intracellular protein transmembrane import (GO:0044743)2.63154544
88cilium or flagellum-dependent cell motility (GO:0001539)2.61180542
89otic vesicle formation (GO:0030916)2.60510747
90retinal ganglion cell axon guidance (GO:0031290)2.58064754
91telencephalon development (GO:0021537)2.55653318
92neuron fate specification (GO:0048665)2.53722665
93cell differentiation in spinal cord (GO:0021515)2.53292651
94spinal cord motor neuron differentiation (GO:0021522)2.52273764
95negative regulation of oligodendrocyte differentiation (GO:0048715)2.49237973
96protein localization to membrane (GO:0072657)2.46856407
97regulation of development, heterochronic (GO:0040034)2.45960159
98organelle disassembly (GO:1903008)2.45598671
99negative regulation of epidermal cell differentiation (GO:0045605)2.45261560
100positive regulation of Notch signaling pathway (GO:0045747)2.42742810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.74718964
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.30653659
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.08219893
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.90335555
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.80079985
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.73300707
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.72610415
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.62893985
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.55505265
10VDR_22108803_ChIP-Seq_LS180_Human2.50803424
11EWS_26573619_Chip-Seq_HEK293_Human2.39753448
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36222394
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21458540
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.18908973
15FUS_26573619_Chip-Seq_HEK293_Human2.15510681
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08619977
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.07396329
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06552478
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02659133
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01962261
21TTF2_22483619_ChIP-Seq_HELA_Human1.95875193
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86068481
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85298079
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82653690
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80994535
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.80372140
27TAF15_26573619_Chip-Seq_HEK293_Human1.75267053
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73526073
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.70689398
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70136214
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67306899
32ZNF274_21170338_ChIP-Seq_K562_Hela1.67278257
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66185493
34RNF2_27304074_Chip-Seq_NSC_Mouse1.63538985
35MYC_18940864_ChIP-ChIP_HL60_Human1.62419046
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61852045
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60423741
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60294084
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57644832
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52720701
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52720701
42IRF1_19129219_ChIP-ChIP_H3396_Human1.51259209
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51147040
44ELK1_19687146_ChIP-ChIP_HELA_Human1.49956277
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49672083
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.48171420
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42960848
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40893235
49P300_19829295_ChIP-Seq_ESCs_Human1.40183970
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38395500
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38090653
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.38072944
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.36061021
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36009648
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.32428745
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31453598
57REST_21632747_ChIP-Seq_MESCs_Mouse1.28297900
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26691683
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24468770
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22380153
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21828970
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21458289
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20873694
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20873694
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.20804729
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18066051
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.16205491
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11282021
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09863557
70XRN2_22483619_ChIP-Seq_HELA_Human1.09483396
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09094542
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09094542
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09094542
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.07291085
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07216612
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07167022
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04882990
78CBP_20019798_ChIP-Seq_JUKART_Human1.04882990
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03016451
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01765135
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00367215
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99523410
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96429837
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95848590
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95748470
86RING1B_27294783_Chip-Seq_ESCs_Mouse0.95630864
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95246622
88FOXP3_21729870_ChIP-Seq_TREG_Human0.94341960
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94163012
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94131943
91CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93434174
92VDR_23849224_ChIP-Seq_CD4+_Human0.93183384
93MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92239139
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90270793
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89895747
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89184809
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.89153108
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.88794471
99JUN_21703547_ChIP-Seq_K562_Human0.86708306
100NANOG_19829295_ChIP-Seq_ESCs_Human0.85918805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.69603204
2MP0003283_abnormal_digestive_organ4.48169767
3MP0003136_yellow_coat_color4.30623627
4MP0006292_abnormal_olfactory_placode3.41474065
5MP0002938_white_spotting2.74659010
6MP0003880_abnormal_central_pattern2.34481196
7MP0008875_abnormal_xenobiotic_pharmacok2.11585460
8MP0002102_abnormal_ear_morphology2.10381260
9MP0008961_abnormal_basal_metabolism2.09803267
10MP0004142_abnormal_muscle_tone2.07879681
11MP0002095_abnormal_skin_pigmentation2.02230994
12MP0002837_dystrophic_cardiac_calcinosis1.99667191
13MP0004742_abnormal_vestibular_system1.98826658
14MP0002277_abnormal_respiratory_mucosa1.95745281
15MP0006072_abnormal_retinal_apoptosis1.94158201
16MP0003806_abnormal_nucleotide_metabolis1.92867545
17MP0000049_abnormal_middle_ear1.82610670
18MP0000778_abnormal_nervous_system1.73953140
19MP0005171_absent_coat_pigmentation1.70691171
20MP0003011_delayed_dark_adaptation1.66415283
21MP0008789_abnormal_olfactory_epithelium1.64359474
22MP0002234_abnormal_pharynx_morphology1.63171754
23MP0000372_irregular_coat_pigmentation1.61964526
24MP0000026_abnormal_inner_ear1.60731278
25MP0002638_abnormal_pupillary_reflex1.55662091
26MP0002272_abnormal_nervous_system1.53632999
27MP0002282_abnormal_trachea_morphology1.45085794
28MP0010030_abnormal_orbit_morphology1.44995239
29MP0003121_genomic_imprinting1.42541137
30MP0002751_abnormal_autonomic_nervous1.38811877
31MP0003119_abnormal_digestive_system1.34906823
32MP0005551_abnormal_eye_electrophysiolog1.33391272
33MP0010386_abnormal_urinary_bladder1.32345584
34MP0005499_abnormal_olfactory_system1.31965931
35MP0005394_taste/olfaction_phenotype1.31965931
36MP0003755_abnormal_palate_morphology1.31457298
37MP0001270_distended_abdomen1.29103438
38MP0009745_abnormal_behavioral_response1.26776396
39MP0003938_abnormal_ear_development1.26509017
40MP0004133_heterotaxia1.24698169
41MP0002572_abnormal_emotion/affect_behav1.24152967
42MP0005423_abnormal_somatic_nervous1.21807186
43MP0001286_abnormal_eye_development1.21334414
44MP0001485_abnormal_pinna_reflex1.19950570
45MP0004145_abnormal_muscle_electrophysio1.17255838
46MP0005646_abnormal_pituitary_gland1.17235351
47MP0005195_abnormal_posterior_eye1.16952299
48MP0002909_abnormal_adrenal_gland1.16815259
49MP0009046_muscle_twitch1.15764863
50MP0006276_abnormal_autonomic_nervous1.14732158
51MP0005253_abnormal_eye_physiology1.14489937
52MP0005174_abnormal_tail_pigmentation1.14120062
53MP0000631_abnormal_neuroendocrine_gland1.13427943
54MP0003122_maternal_imprinting1.12739560
55MP0003787_abnormal_imprinting1.11988936
56MP0001905_abnormal_dopamine_level1.10802614
57MP0002752_abnormal_somatic_nervous1.10799894
58MP0000955_abnormal_spinal_cord1.10385543
59MP0001440_abnormal_grooming_behavior1.09053373
60MP0001293_anophthalmia1.08229419
61MP0000566_synostosis1.08208930
62MP0005084_abnormal_gallbladder_morpholo1.07262668
63MP0002163_abnormal_gland_morphology1.07196207
64MP0002653_abnormal_ependyma_morphology1.06935895
65MP0002067_abnormal_sensory_capabilities1.04351209
66MP0002064_seizures0.99460794
67MP0001486_abnormal_startle_reflex0.99438276
68MP0005379_endocrine/exocrine_gland_phen0.99007936
69MP0002557_abnormal_social/conspecific_i0.98806383
70MP0003315_abnormal_perineum_morphology0.97545252
71MP0003861_abnormal_nervous_system0.96322337
72MP0002882_abnormal_neuron_morphology0.95135218
73MP0001970_abnormal_pain_threshold0.94772235
74MP0001963_abnormal_hearing_physiology0.94729351
75MP0005391_vision/eye_phenotype0.92263960
76MP0002210_abnormal_sex_determination0.92027760
77MP0003890_abnormal_embryonic-extraembry0.91899932
78MP0002116_abnormal_craniofacial_bone0.90983340
79MP0003635_abnormal_synaptic_transmissio0.90739135
80MP0001324_abnormal_eye_pigmentation0.90411238
81MP0008932_abnormal_embryonic_tissue0.89742221
82MP0002152_abnormal_brain_morphology0.83639354
83MP0002734_abnormal_mechanical_nocicepti0.83308681
84MP0002160_abnormal_reproductive_system0.82860632
85MP0003937_abnormal_limbs/digits/tail_de0.82153831
86MP0000538_abnormal_urinary_bladder0.80735142
87MP0000534_abnormal_ureter_morphology0.79874618
88MP0005085_abnormal_gallbladder_physiolo0.78975396
89MP0000762_abnormal_tongue_morphology0.78816386
90MP0004019_abnormal_vitamin_homeostasis0.78477445
91MP0002184_abnormal_innervation0.77046139
92MP0003186_abnormal_redox_activity0.76619868
93MP0003646_muscle_fatigue0.76544466
94MP0003942_abnormal_urinary_system0.75926580
95MP0002063_abnormal_learning/memory/cond0.75881254
96MP0004885_abnormal_endolymph0.75616664
97MP0002249_abnormal_larynx_morphology0.74580547
98MP0008058_abnormal_DNA_repair0.74366822
99MP0003935_abnormal_craniofacial_develop0.71847016
100MP0002928_abnormal_bile_duct0.68761238

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.61338657
2Abnormality of midbrain morphology (HP:0002418)4.24179896
3Molar tooth sign on MRI (HP:0002419)4.24179896
4Acute necrotizing encephalopathy (HP:0006965)4.12491698
5Macrocytic anemia (HP:0001972)4.05549494
6Abnormality of cells of the erythroid lineage (HP:0012130)4.04832475
7Pancreatic fibrosis (HP:0100732)4.01465616
8Abnormal number of erythroid precursors (HP:0012131)3.97666703
9True hermaphroditism (HP:0010459)3.88519713
10Pancreatic cysts (HP:0001737)3.87177803
11Rhinitis (HP:0012384)3.69372543
12Mitochondrial inheritance (HP:0001427)3.66778804
13Increased hepatocellular lipid droplets (HP:0006565)3.62737891
14Abnormal mitochondria in muscle tissue (HP:0008316)3.58902634
15Progressive macrocephaly (HP:0004481)3.38497748
16Cystic liver disease (HP:0006706)3.33643068
17Acute encephalopathy (HP:0006846)3.32782549
18Depressed nasal tip (HP:0000437)3.20618509
19Diastasis recti (HP:0001540)3.15576379
20Lipid accumulation in hepatocytes (HP:0006561)3.08433570
21Pallor (HP:0000980)2.96050718
22Duplicated collecting system (HP:0000081)2.93673064
2311 pairs of ribs (HP:0000878)2.90371555
24Malnutrition (HP:0004395)2.90243948
25Increased CSF lactate (HP:0002490)2.87579010
26Partial duplication of thumb phalanx (HP:0009944)2.85244439
27Abnormal respiratory motile cilium morphology (HP:0005938)2.81735624
28Abnormal respiratory epithelium morphology (HP:0012253)2.81735624
29Absent/shortened dynein arms (HP:0200106)2.77917224
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.77917224
31Myokymia (HP:0002411)2.76377776
32Congenital, generalized hypertrichosis (HP:0004540)2.74991292
33Volvulus (HP:0002580)2.68364520
34Abnormal respiratory motile cilium physiology (HP:0012261)2.67344143
35Abnormality of the renal collecting system (HP:0004742)2.64966071
36Nephronophthisis (HP:0000090)2.64794735
37Bifid tongue (HP:0010297)2.62335288
38Anophthalmia (HP:0000528)2.60835408
39Duplication of thumb phalanx (HP:0009942)2.59569170
40Abnormal ciliary motility (HP:0012262)2.59544449
41Renal Fanconi syndrome (HP:0001994)2.57512637
42Septo-optic dysplasia (HP:0100842)2.52080501
43Sclerocornea (HP:0000647)2.48274007
44Anencephaly (HP:0002323)2.48211936
45Congenital stationary night blindness (HP:0007642)2.46751734
46Partial duplication of the phalanx of hand (HP:0009999)2.44959040
47Median cleft lip (HP:0000161)2.39223751
48Optic disc pallor (HP:0000543)2.34840305
49Type II lissencephaly (HP:0007260)2.33796071
50Hepatocellular necrosis (HP:0001404)2.33164762
51Colon cancer (HP:0003003)2.27018316
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23038374
53Pendular nystagmus (HP:0012043)2.22514458
54Exertional dyspnea (HP:0002875)2.20826199
55Abnormality of the renal medulla (HP:0100957)2.19321076
56Fibular hypoplasia (HP:0003038)2.17217686
57Leukodystrophy (HP:0002415)2.15006311
58Abnormality of renal resorption (HP:0011038)2.13980035
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13629568
60Intestinal atresia (HP:0011100)2.13613711
61Broad alveolar ridges (HP:0000187)2.11117162
62Male pseudohermaphroditism (HP:0000037)2.08092559
63Hepatic necrosis (HP:0002605)2.05688973
64Furrowed tongue (HP:0000221)2.05176795
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.05129893
66Absent septum pellucidum (HP:0001331)2.04917440
67Absent thumb (HP:0009777)2.03782541
68Depressed nasal ridge (HP:0000457)2.03664241
69Increased intramyocellular lipid droplets (HP:0012240)2.02133677
70Microretrognathia (HP:0000308)2.01257666
71Genu varum (HP:0002970)2.00883665
72Cerebral edema (HP:0002181)1.99624048
73Spastic tetraparesis (HP:0001285)1.99167075
74Abnormality of the diencephalon (HP:0010662)1.97440122
75Limb dystonia (HP:0002451)1.96553285
76Triphalangeal thumb (HP:0001199)1.95766529
77Conjunctival hamartoma (HP:0100780)1.95316756
78Missing ribs (HP:0000921)1.93792682
79Abolished electroretinogram (ERG) (HP:0000550)1.91877751
80Birth length less than 3rd percentile (HP:0003561)1.91240325
81Medial flaring of the eyebrow (HP:0010747)1.90096393
82Posterior subcapsular cataract (HP:0007787)1.87568127
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87420632
84Preaxial hand polydactyly (HP:0001177)1.87190697
85Congenital hepatic fibrosis (HP:0002612)1.86845249
86Maternal diabetes (HP:0009800)1.85561501
87Respiratory failure (HP:0002878)1.84077319
88Short tibia (HP:0005736)1.81543807
89Postaxial foot polydactyly (HP:0001830)1.80485934
90Highly arched eyebrow (HP:0002553)1.78861645
91Sex reversal (HP:0012245)1.78460545
92Abnormal sex determination (HP:0012244)1.78460545
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78161772
94Cerebellar dysplasia (HP:0007033)1.77279186
95Abnormality of reticulocytes (HP:0004312)1.77225114
96Aganglionic megacolon (HP:0002251)1.72964835
97Bilateral microphthalmos (HP:0007633)1.71184581
98Meningocele (HP:0002435)1.69870441
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.69786055
100Gastrointestinal atresia (HP:0002589)1.69245465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.34394925
2STK163.59158635
3PNCK2.76810564
4EPHB22.47190003
5NUAK12.47013200
6MAP3K42.39218436
7NEK12.24033443
8MAP2K72.08614988
9WEE12.07926848
10DYRK32.04584943
11CDK32.00626864
12MAPK151.95769969
13WNK31.91979494
14MAPK71.88334626
15ZAK1.88333862
16VRK21.86312666
17LATS21.84472824
18NEK21.81657092
19PASK1.75857269
20PINK11.71271089
21CDC71.70459859
22TLK11.62053192
23VRK11.54346887
24ACVR1B1.52102318
25TGFBR11.39293337
26MKNK11.38392438
27BRSK21.38119138
28DYRK21.37674553
29MAPK131.37570747
30MAP3K101.37340294
31MAP2K41.35248586
32WNK41.30704931
33TSSK61.27423016
34UHMK11.27384199
35NME11.20861300
36DMPK1.17431491
37CASK1.16209492
38MAP3K121.15974997
39INSRR1.15268163
40IRAK41.14062544
41MARK11.13241808
42LRRK21.07400401
43BMPR1B1.04241862
44KSR11.02169519
45CDK81.01659710
46BUB11.01125331
47RPS6KA50.99655754
48ADRBK20.98959270
49MINK10.98439971
50MAP4K20.92995010
51NTRK20.91953930
52PRKG10.89605446
53IRAK10.83172191
54MKNK20.82141978
55PRKCG0.79706829
56ADRBK10.77653163
57AURKB0.76819008
58CCNB10.73921720
59CHEK20.71698611
60STK40.71531245
61NME20.69637369
62RPS6KA10.69252026
63PLK30.68924237
64IRAK20.66147389
65PHKG20.64213739
66PHKG10.64213739
67RPS6KA40.64044445
68PKN10.63827094
69PRKCE0.60654999
70CSNK2A10.60318200
71PIK3CA0.59719271
72PRKCH0.58112135
73TRIM280.57597725
74OBSCN0.57007380
75DYRK1A0.56634147
76PRKACA0.55070374
77CAMK2A0.49573150
78CSNK2A20.48845997
79ILK0.47933043
80ERBB20.47643184
81GRK10.45695832
82PAK30.45646508
83MAP2K20.44000717
84MYLK0.43582309
85CAMK10.41888486
86PLK10.38775157
87KIT0.37847740
88PLK40.35194770
89IKBKE0.35012169
90DYRK1B0.34737015
91PRKCD0.33504977
92MARK30.33233197
93BRSK10.32485387
94DAPK30.31845389
95PRKD30.31680360
96AURKA0.30347308
97TIE10.30203351
98EPHA40.29427749
99AKT10.29274452
100MAPKAPK50.28340921

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.91988326
2Oxidative phosphorylation_Homo sapiens_hsa001905.01300588
3Parkinsons disease_Homo sapiens_hsa050124.40470638
4Huntingtons disease_Homo sapiens_hsa050163.31642468
5Cardiac muscle contraction_Homo sapiens_hsa042603.13664134
6Alzheimers disease_Homo sapiens_hsa050103.01732061
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.85842610
8Protein export_Homo sapiens_hsa030602.43660718
9Sulfur relay system_Homo sapiens_hsa041222.25808112
10RNA polymerase_Homo sapiens_hsa030202.12270134
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.94695443
12Folate biosynthesis_Homo sapiens_hsa007901.82271930
13Proteasome_Homo sapiens_hsa030501.74843307
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69274467
15Asthma_Homo sapiens_hsa053101.64016175
16Nicotine addiction_Homo sapiens_hsa050331.61298207
17Spliceosome_Homo sapiens_hsa030401.49225446
18RNA degradation_Homo sapiens_hsa030181.39809260
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.33902049
20Homologous recombination_Homo sapiens_hsa034401.31117492
21Phototransduction_Homo sapiens_hsa047441.29208514
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.10416444
23Basal transcription factors_Homo sapiens_hsa030221.08133456
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02678872
25Nitrogen metabolism_Homo sapiens_hsa009101.02464228
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02019947
27Taste transduction_Homo sapiens_hsa047420.99776996
28Chemical carcinogenesis_Homo sapiens_hsa052040.96256788
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94994238
30Mismatch repair_Homo sapiens_hsa034300.91578935
31DNA replication_Homo sapiens_hsa030300.90598152
32Base excision repair_Homo sapiens_hsa034100.90178745
33Morphine addiction_Homo sapiens_hsa050320.84658594
34Basal cell carcinoma_Homo sapiens_hsa052170.83987046
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81047181
36Linoleic acid metabolism_Homo sapiens_hsa005910.81029176
37Fanconi anemia pathway_Homo sapiens_hsa034600.79052106
38Purine metabolism_Homo sapiens_hsa002300.78416987
39GABAergic synapse_Homo sapiens_hsa047270.78355725
40Pyrimidine metabolism_Homo sapiens_hsa002400.78118653
41Glutathione metabolism_Homo sapiens_hsa004800.77640177
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77403685
43Butanoate metabolism_Homo sapiens_hsa006500.77052208
44Systemic lupus erythematosus_Homo sapiens_hsa053220.73284643
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71471489
46One carbon pool by folate_Homo sapiens_hsa006700.71099666
47Cocaine addiction_Homo sapiens_hsa050300.70944603
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.68888816
49Glutamatergic synapse_Homo sapiens_hsa047240.64609085
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.63665615
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61132934
52Circadian entrainment_Homo sapiens_hsa047130.60913020
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59388393
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.59259394
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56344836
56Autoimmune thyroid disease_Homo sapiens_hsa053200.54480792
57Insulin secretion_Homo sapiens_hsa049110.52259620
58Caffeine metabolism_Homo sapiens_hsa002320.51503950
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51235906
60Tryptophan metabolism_Homo sapiens_hsa003800.51053812
61Allograft rejection_Homo sapiens_hsa053300.50983497
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50981848
63Olfactory transduction_Homo sapiens_hsa047400.50475694
64Nucleotide excision repair_Homo sapiens_hsa034200.49794938
65Peroxisome_Homo sapiens_hsa041460.49560201
66Tyrosine metabolism_Homo sapiens_hsa003500.49189100
67Collecting duct acid secretion_Homo sapiens_hsa049660.48594819
68Hedgehog signaling pathway_Homo sapiens_hsa043400.48579640
69Type I diabetes mellitus_Homo sapiens_hsa049400.47549705
70Cell cycle_Homo sapiens_hsa041100.47160636
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46610533
72Graft-versus-host disease_Homo sapiens_hsa053320.45910697
73Notch signaling pathway_Homo sapiens_hsa043300.45075086
74Metabolic pathways_Homo sapiens_hsa011000.44277896
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42583887
76Fat digestion and absorption_Homo sapiens_hsa049750.40237608
77Alcoholism_Homo sapiens_hsa050340.39573895
78TGF-beta signaling pathway_Homo sapiens_hsa043500.38479073
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37505301
80ECM-receptor interaction_Homo sapiens_hsa045120.36772958
81Arachidonic acid metabolism_Homo sapiens_hsa005900.36565379
82RNA transport_Homo sapiens_hsa030130.36448100
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35481568
84Retinol metabolism_Homo sapiens_hsa008300.35081353
85Serotonergic synapse_Homo sapiens_hsa047260.34715455
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34704210
87Mineral absorption_Homo sapiens_hsa049780.34498234
88Steroid biosynthesis_Homo sapiens_hsa001000.33434789
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32851808
90p53 signaling pathway_Homo sapiens_hsa041150.32511728
91Rheumatoid arthritis_Homo sapiens_hsa053230.29589814
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27981807
93Sulfur metabolism_Homo sapiens_hsa009200.26191587
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25336724
95Vitamin digestion and absorption_Homo sapiens_hsa049770.23986505
96Dorso-ventral axis formation_Homo sapiens_hsa043200.23880143
97Cholinergic synapse_Homo sapiens_hsa047250.22654827
98Dopaminergic synapse_Homo sapiens_hsa047280.22312568
99Axon guidance_Homo sapiens_hsa043600.22196871
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20551979

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