F11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.89265903
2epoxygenase P450 pathway (GO:0019373)7.72829493
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.58897369
4L-phenylalanine catabolic process (GO:0006559)7.58897369
5omega-hydroxylase P450 pathway (GO:0097267)7.46854231
6L-phenylalanine metabolic process (GO:0006558)7.24506413
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.24506413
8aromatic amino acid family catabolic process (GO:0009074)6.84195886
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.33330656
10tryptophan catabolic process (GO:0006569)6.24484390
11indole-containing compound catabolic process (GO:0042436)6.24484390
12indolalkylamine catabolic process (GO:0046218)6.24484390
13kynurenine metabolic process (GO:0070189)6.13755375
14bile acid biosynthetic process (GO:0006699)6.02886235
15glyoxylate metabolic process (GO:0046487)5.91451957
16tryptophan metabolic process (GO:0006568)5.86739809
17negative regulation of fibrinolysis (GO:0051918)5.83152503
18urea metabolic process (GO:0019627)5.65641646
19urea cycle (GO:0000050)5.65641646
20high-density lipoprotein particle remodeling (GO:0034375)5.65087750
21regulation of plasminogen activation (GO:0010755)5.63685718
22regulation of protein activation cascade (GO:2000257)5.61716100
23alpha-linolenic acid metabolic process (GO:0036109)5.56506218
24complement activation, alternative pathway (GO:0006957)5.55888979
25protein carboxylation (GO:0018214)5.51573740
26peptidyl-glutamic acid carboxylation (GO:0017187)5.51573740
27cysteine metabolic process (GO:0006534)5.30809304
28* regulation of fibrinolysis (GO:0051917)5.29070332
29sulfur amino acid catabolic process (GO:0000098)5.26738157
30regulation of complement activation (GO:0030449)5.24213434
31nitrogen cycle metabolic process (GO:0071941)5.19481689
32drug metabolic process (GO:0017144)5.19008737
33bile acid metabolic process (GO:0008206)5.12005733
34intestinal cholesterol absorption (GO:0030299)5.10409775
35serine family amino acid catabolic process (GO:0009071)5.07743812
36reverse cholesterol transport (GO:0043691)4.97612720
37aromatic amino acid family metabolic process (GO:0009072)4.96421104
38ethanol metabolic process (GO:0006067)4.95560727
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.92222003
40regulation of cholesterol esterification (GO:0010872)4.88799659
41regulation of humoral immune response (GO:0002920)4.88207649
42protein-lipid complex remodeling (GO:0034368)4.84352718
43macromolecular complex remodeling (GO:0034367)4.84352718
44plasma lipoprotein particle remodeling (GO:0034369)4.84352718
45regulation of triglyceride catabolic process (GO:0010896)4.84231439
46tyrosine metabolic process (GO:0006570)4.76854672
47oxidative demethylation (GO:0070989)4.67663249
48acylglycerol homeostasis (GO:0055090)4.67173543
49triglyceride homeostasis (GO:0070328)4.67173543
50homocysteine metabolic process (GO:0050667)4.67005782
51alpha-amino acid catabolic process (GO:1901606)4.62279229
52phospholipid efflux (GO:0033700)4.61699287
53lysine metabolic process (GO:0006553)4.55709249
54lysine catabolic process (GO:0006554)4.55709249
55negative regulation of cholesterol transport (GO:0032375)4.55123545
56negative regulation of sterol transport (GO:0032372)4.55123545
57amino-acid betaine metabolic process (GO:0006577)4.52844078
58* negative regulation of blood coagulation (GO:0030195)4.50983629
59* negative regulation of hemostasis (GO:1900047)4.50983629
60plasma lipoprotein particle clearance (GO:0034381)4.45787180
61cellular ketone body metabolic process (GO:0046950)4.43552993
62coenzyme catabolic process (GO:0009109)4.41862415
63indolalkylamine metabolic process (GO:0006586)4.41692236
64glycine metabolic process (GO:0006544)4.41385022
65positive regulation of blood coagulation (GO:0030194)4.41339129
66positive regulation of hemostasis (GO:1900048)4.41339129
67imidazole-containing compound metabolic process (GO:0052803)4.41050184
68bile acid and bile salt transport (GO:0015721)4.39449532
69regulation of apoptotic cell clearance (GO:2000425)4.37326539
70positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.37182198
71cellular biogenic amine catabolic process (GO:0042402)4.32561221
72amine catabolic process (GO:0009310)4.32561221
73cholesterol efflux (GO:0033344)4.32005420
74negative regulation of complement activation (GO:0045916)4.30627015
75glutamate metabolic process (GO:0006536)4.26323431
76cellular amino acid catabolic process (GO:0009063)4.24483028
77cellular glucuronidation (GO:0052695)4.19100103
78phenylpropanoid metabolic process (GO:0009698)4.17741461
79serine family amino acid metabolic process (GO:0009069)4.15851620
80fibrinolysis (GO:0042730)4.13526709
81benzene-containing compound metabolic process (GO:0042537)4.12454075
82* negative regulation of coagulation (GO:0050819)4.11251371
83plasma lipoprotein particle assembly (GO:0034377)4.07957011
84disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.07737268
85killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.07737268
86cellular modified amino acid catabolic process (GO:0042219)4.06411186
87ethanol oxidation (GO:0006069)4.06320710
88dicarboxylic acid biosynthetic process (GO:0043650)4.05701458
89positive regulation of coagulation (GO:0050820)4.05622892
90* negative regulation of wound healing (GO:0061045)4.02965774
91serine family amino acid biosynthetic process (GO:0009070)4.02618252
92aldehyde catabolic process (GO:0046185)4.01633247
93low-density lipoprotein particle remodeling (GO:0034374)4.00381859
94arginine metabolic process (GO:0006525)3.99870968
95protein-lipid complex subunit organization (GO:0071825)3.95178687
96complement activation, classical pathway (GO:0006958)3.92388433
97complement activation (GO:0006956)3.86828362
98drug catabolic process (GO:0042737)3.85755242
99cytolysis (GO:0019835)3.84966782
100ketone body metabolic process (GO:1902224)3.83898460
101positive regulation of lipoprotein lipase activity (GO:0051006)3.83228119
102positive regulation of triglyceride lipase activity (GO:0061365)3.83228119
103phospholipid homeostasis (GO:0055091)3.82749158
104cofactor catabolic process (GO:0051187)3.82400614
105positive regulation of fatty acid biosynthetic process (GO:0045723)3.78124651
106cholesterol homeostasis (GO:0042632)3.77166795
107very-low-density lipoprotein particle assembly (GO:0034379)3.76772963
108* protein activation cascade (GO:0072376)3.75764970
109positive regulation of lipid catabolic process (GO:0050996)3.74325950
110regulation of bile acid biosynthetic process (GO:0070857)3.73056883
111negative regulation of lipase activity (GO:0060192)3.71475016
112uronic acid metabolic process (GO:0006063)3.71365707
113glucuronate metabolic process (GO:0019585)3.71365707
114sterol homeostasis (GO:0055092)3.70789891
115organic acid catabolic process (GO:0016054)3.69653881
116carboxylic acid catabolic process (GO:0046395)3.69653881
117plasma lipoprotein particle organization (GO:0071827)3.69454442
118negative regulation of protein activation cascade (GO:2000258)3.68606027
119regulation of cholesterol homeostasis (GO:2000188)3.67487677
120S-adenosylmethionine metabolic process (GO:0046500)3.67311241
121protein-lipid complex assembly (GO:0065005)3.65500268
122acetyl-CoA metabolic process (GO:0006084)3.65172249
123* blood coagulation, intrinsic pathway (GO:0007597)3.64150315
124opsonization (GO:0008228)3.62800306
125acute-phase response (GO:0006953)3.59147757
126acute inflammatory response (GO:0002526)3.58206838
127response to mercury ion (GO:0046689)3.51597827
128flavonoid metabolic process (GO:0009812)3.44307244
129lipoprotein metabolic process (GO:0042157)3.43978648
130regulation of acute inflammatory response (GO:0002673)3.43700159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.36273561
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18423019
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.11276756
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.50613256
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29854468
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.12481291
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.75898313
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06583997
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03428559
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04900551
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0668704
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97969302
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91105775
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.62710117
15HTT_18923047_ChIP-ChIP_STHdh_Human1.58371799
16CLOCK_20551151_ChIP-Seq_293T_Human1.50369675
17GATA1_22025678_ChIP-Seq_K562_Human1.45263925
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40213214
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34693707
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25923273
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21280293
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19070422
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16946804
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11663068
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.08324733
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.07449975
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02754206
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02018562
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94667524
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93953911
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91147885
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88559111
33IRF8_22096565_ChIP-ChIP_GC-B_Human0.85494479
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85076595
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83479534
36RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82373985
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80319751
38GATA4_25053715_ChIP-Seq_YYC3_Human0.78743856
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76815537
40NFE2_27457419_Chip-Seq_LIVER_Mouse0.76339904
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76049640
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75819309
43SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75317468
44* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75009103
45RARA_24833708_ChIP-Seq_LIVER_Mouse0.74793450
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.74768710
47SOX2_20726797_ChIP-Seq_SW620_Human0.74313364
48CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72689880
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70804911
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70596700
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70534756
52ZNF263_19887448_ChIP-Seq_K562_Human0.69605649
53PCGF2_27294783_Chip-Seq_NPCs_Mouse0.69052199
54SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68833232
55AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66558952
56ESR2_21235772_ChIP-Seq_MCF-7_Human0.65266939
57RARB_24833708_ChIP-Seq_LIVER_Mouse0.64903351
58NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63983657
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63983657
60RAC3_21632823_ChIP-Seq_H3396_Human0.63328496
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62811654
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60981217
63SMAD1_18555785_Chip-Seq_ESCs_Mouse0.60970175
64EZH2_27294783_Chip-Seq_NPCs_Mouse0.60263885
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59623834
66* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58935787
67SUZ12_27294783_Chip-Seq_NPCs_Mouse0.58799456
68TP53_18474530_ChIP-ChIP_U2OS_Human0.58037606
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57868723
70ESRRB_18555785_Chip-Seq_ESCs_Mouse0.57279242
71PIAS1_25552417_ChIP-Seq_VCAP_Human0.57066407
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.56960088
73CEBPB_22108803_ChIP-Seq_LS180_Human0.56372245
74OCT4_18555785_Chip-Seq_ESCs_Mouse0.56134927
75POU5F1_16518401_ChIP-PET_MESCs_Mouse0.55728224
76* SOX2_21211035_ChIP-Seq_LN229_Human0.55688918
77MYC_19829295_ChIP-Seq_ESCs_Human0.55159494
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55045413
79RUNX1_27457419_Chip-Seq_LIVER_Mouse0.54818879
80CDX2_22108803_ChIP-Seq_LS180_Human0.54736153
81EGR1_19032775_ChIP-ChIP_M12_Human0.54571419
82FOXA1_25552417_ChIP-Seq_VCAP_Human0.53058417
83LXR_22292898_ChIP-Seq_THP-1_Human0.52922829
84MYC_19915707_ChIP-ChIP_AK7_Human0.52670963
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52591842
86NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.52384348
87NFIB_24661679_ChIP-Seq_LUNG_Mouse0.52208426
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51939975
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51195307
90TP53_16413492_ChIP-PET_HCT116_Human0.50986394
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50859399
92PU1_27457419_Chip-Seq_LIVER_Mouse0.50761094
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.50655264
94CSB_26484114_Chip-Seq_FIBROBLAST_Human0.49682397
95KLF4_18555785_Chip-Seq_ESCs_Mouse0.49547321
96* AR_20517297_ChIP-Seq_VCAP_Human0.49285683
97ZFX_18555785_Chip-Seq_ESCs_Mouse0.49218464
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.48854784
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.48441494
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.48126911
101CRX_20693478_ChIP-Seq_RETINA_Mouse0.47949682
102CBX2_22325352_ChIP-Seq_293T-Rex_Human0.47667736
103CBP_21632823_ChIP-Seq_H3396_Human0.47632492
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.47152026
105EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.46673092
106P53_21459846_ChIP-Seq_SAOS-2_Human0.46507497
107TAF15_26573619_Chip-Seq_HEK293_Human0.46221582
108STAT1_17558387_ChIP-Seq_HELA_Human0.46217154
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.45266588
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.44332551
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44265463
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.44054034
113GATA1_19941826_ChIP-Seq_K562_Human0.43828262
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.43767872
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43597829
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42664257
117TAF2_19829295_ChIP-Seq_ESCs_Human0.42577568
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.42125972
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41049346
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40335073
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40316539
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40132898
123GATA2_19941826_ChIP-Seq_K562_Human0.39867489
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.39169406
125BCAT_22108803_ChIP-Seq_LS180_Human0.38903635
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38902558
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.38323134
128GATA6_25053715_ChIP-Seq_YYC3_Human0.38275974
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.38113236
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37908128
131SPI1_26923725_Chip-Seq_HPCs_Mouse0.35691224
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35199852
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34945569
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.34305167
135CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33809489
136NCOR_22424771_ChIP-Seq_293T_Human0.33727811
137IRF1_19129219_ChIP-ChIP_H3396_Human0.32871918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29386215
2MP0005360_urolithiasis7.58999199
3MP0005085_abnormal_gallbladder_physiolo6.47987604
4MP0005365_abnormal_bile_salt6.15906045
5MP0008875_abnormal_xenobiotic_pharmacok5.03611786
6MP0003806_abnormal_nucleotide_metabolis4.36557274
7MP0003252_abnormal_bile_duct3.92302495
8MP0010329_abnormal_lipoprotein_level3.63812019
9MP0009840_abnormal_foam_cell3.29175735
10MP0005083_abnormal_biliary_tract3.12130362
11MP0003195_calcinosis2.86698820
12MP0005332_abnormal_amino_acid2.72977094
13MP0001666_abnormal_nutrient_absorption2.63031461
14MP0003191_abnormal_cellular_cholesterol2.41839452
15MP0000609_abnormal_liver_physiology2.19114953
16MP0002118_abnormal_lipid_homeostasis2.11063088
17MP0004019_abnormal_vitamin_homeostasis2.10249864
18MP0002138_abnormal_hepatobiliary_system1.94968224
19MP0003868_abnormal_feces_composition1.91826086
20MP0005319_abnormal_enzyme/_coenzyme1.84254619
21MP0003122_maternal_imprinting1.77036854
22MP0001764_abnormal_homeostasis1.67825904
23MP0009697_abnormal_copulation1.65698882
24MP0005584_abnormal_enzyme/coenzyme_acti1.57618868
25MP0003011_delayed_dark_adaptation1.43973161
26MP0003656_abnormal_erythrocyte_physiolo1.32550965
27MP0005451_abnormal_body_composition1.32412702
28MP0003186_abnormal_redox_activity1.23786627
29MP0009643_abnormal_urine_homeostasis1.21953083
30MP0005647_abnormal_sex_gland1.18667913
31MP0003705_abnormal_hypodermis_morpholog1.17301124
32* MP0000598_abnormal_liver_morphology1.17025537
33MP0000604_amyloidosis1.11681103
34MP0002254_reproductive_system_inflammat1.10071940
35MP0009764_decreased_sensitivity_to1.07280137
36MP0009763_increased_sensitivity_to1.04484345
37MP0000566_synostosis0.95094955
38MP0005636_abnormal_mineral_homeostasis0.94091469
39MP0008469_abnormal_protein_level0.91683481
40MP0005058_abnormal_lysosome_morphology0.89602290
41* MP0001915_intracranial_hemorrhage0.88406037
42* MP0009642_abnormal_blood_homeostasis0.87447399
43MP0005408_hypopigmentation0.85929039
44MP0005376_homeostasis/metabolism_phenot0.81526577
45MP0006036_abnormal_mitochondrial_physio0.80872418
46MP0005084_abnormal_gallbladder_morpholo0.80354634
47MP0009765_abnormal_xenobiotic_induced0.79102228
48MP0003172_abnormal_lysosome_physiology0.78542998
49MP0002078_abnormal_glucose_homeostasis0.77933895
50MP0002876_abnormal_thyroid_physiology0.77406053
51MP0005670_abnormal_white_adipose0.76279292
52MP0003879_abnormal_hair_cell0.76188771
53MP0005220_abnormal_exocrine_pancreas0.76034774
54MP0002089_abnormal_postnatal_growth/wei0.75707771
55MP0002971_abnormal_brown_adipose0.72011098
56MP0005334_abnormal_fat_pad0.69367194
57MP0004130_abnormal_muscle_cell0.68839132
58MP0003690_abnormal_glial_cell0.68804155
59MP0005535_abnormal_body_temperature0.68219851
60MP0001661_extended_life_span0.67632366
61MP0009053_abnormal_anal_canal0.67230391
62MP0005266_abnormal_metabolism0.65631052
63MP0000639_abnormal_adrenal_gland0.63202694
64MP0003329_amyloid_beta_deposits0.62635539
65MP0005464_abnormal_platelet_physiology0.57774676
66MP0003123_paternal_imprinting0.57719563
67MP0006035_abnormal_mitochondrial_morpho0.56454884
68MP0001756_abnormal_urination0.56294880
69MP0005448_abnormal_energy_balance0.55455518
70MP0005187_abnormal_penis_morphology0.51337853
71MP0005395_other_phenotype0.49966140
72MP0002822_catalepsy0.49399506
73MP0002909_abnormal_adrenal_gland0.48128194
74MP0003724_increased_susceptibility_to0.47414907
75MP0009780_abnormal_chondrocyte_physiolo0.47406110
76MP0002249_abnormal_larynx_morphology0.46863537
77MP0003718_maternal_effect0.46455892
78MP0003638_abnormal_response/metabolism_0.46440145
79MP0002928_abnormal_bile_duct0.46073623
80MP0008874_decreased_physiological_sensi0.45692501
81MP0004381_abnormal_hair_follicle0.45509015
82MP0005023_abnormal_wound_healing0.45385614
83MP0003436_decreased_susceptibility_to0.44850586
84MP0004782_abnormal_surfactant_physiolog0.44537211
85MP0002136_abnormal_kidney_physiology0.44216167
86MP0008873_increased_physiological_sensi0.44132100
87MP0004043_abnormal_pH_regulation0.42604711
88MP0002837_dystrophic_cardiac_calcinosis0.42107800
89MP0005409_darkened_coat_color0.41729168
90MP0004272_abnormal_basement_membrane0.41571727
91MP0005167_abnormal_blood-brain_barrier0.41035823
92MP0003953_abnormal_hormone_level0.40913756
93MP0000579_abnormal_nail_morphology0.40772174
94MP0009384_cardiac_valve_regurgitation0.38754777
95MP0005248_abnormal_Harderian_gland0.38335423
96MP0008872_abnormal_physiological_respon0.37499308
97MP0009672_abnormal_birth_weight0.37172560
98MP0001944_abnormal_pancreas_morphology0.36237823
99MP0005666_abnormal_adipose_tissue0.35593214
100MP0002796_impaired_skin_barrier0.35394679
101MP0006082_CNS_inflammation0.35320263
102MP0004883_abnormal_blood_vessel0.34810605
103MP0000249_abnormal_blood_vessel0.33482008
104MP0000920_abnormal_myelination0.32688039
105MP0009115_abnormal_fat_cell0.32178782
106MP0001243_abnormal_dermal_layer0.32113390
107MP0003633_abnormal_nervous_system0.31747390
108MP0002168_other_aberrant_phenotype0.30803913
109MP0003183_abnormal_peptide_metabolism0.30766710
110MP0001881_abnormal_mammary_gland0.30402680
111MP0001853_heart_inflammation0.30189480
112MP0002970_abnormal_white_adipose0.30122101
113MP0003632_abnormal_nervous_system0.30057802
114MP0000230_abnormal_systemic_arterial0.29799678
115MP0001845_abnormal_inflammatory_respons0.28990285
116MP0005379_endocrine/exocrine_gland_phen0.28147931
117MP0003878_abnormal_ear_physiology0.27959915
118MP0005377_hearing/vestibular/ear_phenot0.27959915
119MP0003567_abnormal_fetal_cardiomyocyte0.27859893
120MP0005164_abnormal_response_to0.27807488
121MP0000427_abnormal_hair_cycle0.24920509
122MP0003631_nervous_system_phenotype0.24878721
123MP0009785_altered_susceptibility_to0.24820112
124MP0002060_abnormal_skin_morphology0.24803584
125* MP0005166_decreased_susceptibility_to0.24685060
126MP0005646_abnormal_pituitary_gland0.23796497
127MP0001324_abnormal_eye_pigmentation0.23433237
128MP0002135_abnormal_kidney_morphology0.23066518
129MP0004264_abnormal_extraembryonic_tissu0.22937641
130MP0002090_abnormal_vision0.21920647

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.61303462
2Intrahepatic cholestasis (HP:0001406)7.45420591
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.36674413
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60042925
5Hypobetalipoproteinemia (HP:0003563)6.37868028
6Xanthomatosis (HP:0000991)6.28150940
7* Prolonged partial thromboplastin time (HP:0003645)6.27118918
8Complement deficiency (HP:0004431)5.71802416
9Hyperlipoproteinemia (HP:0010980)5.50963933
10Joint hemorrhage (HP:0005261)4.99597389
11Hypolipoproteinemia (HP:0010981)4.84577992
12Abnormality of the common coagulation pathway (HP:0010990)4.69831131
13Hyperammonemia (HP:0001987)4.55558240
14Epidermoid cyst (HP:0200040)4.47812202
15Hyperglycinemia (HP:0002154)4.42539179
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.41891737
17Hypoalphalipoproteinemia (HP:0003233)4.27503734
18Ketosis (HP:0001946)4.23299090
19Fat malabsorption (HP:0002630)4.19300386
20Abnormality of complement system (HP:0005339)4.17664336
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.17190903
22Abnormality of methionine metabolism (HP:0010901)4.16955408
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06359786
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.01329667
25Abnormality of glycine metabolism (HP:0010895)3.88216549
26Abnormality of serine family amino acid metabolism (HP:0010894)3.88216549
27Hypoglycemic coma (HP:0001325)3.87291223
28Hyperglycinuria (HP:0003108)3.85949934
29Conjugated hyperbilirubinemia (HP:0002908)3.76304105
30Abnormality of pyrimidine metabolism (HP:0004353)3.76216126
31Hypercholesterolemia (HP:0003124)3.61934073
32Hyperbilirubinemia (HP:0002904)3.35168278
33Spontaneous abortion (HP:0005268)3.31462823
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30633525
35* Abnormality of the intrinsic pathway (HP:0010989)3.27379830
36Abnormality of fatty-acid metabolism (HP:0004359)3.26326765
37Steatorrhea (HP:0002570)3.16764570
38Hypochromic microcytic anemia (HP:0004840)3.11719333
39Delayed CNS myelination (HP:0002188)3.07276445
40Myocardial infarction (HP:0001658)3.04222684
41Abnormality of serum amino acid levels (HP:0003112)3.02436371
42Hepatocellular carcinoma (HP:0001402)3.00654924
43Abnormality of nucleobase metabolism (HP:0010932)2.99891800
44Ketoacidosis (HP:0001993)2.97302106
45Purpura (HP:0000979)2.91730111
46Systemic lupus erythematosus (HP:0002725)2.89351237
47Skin nodule (HP:0200036)2.76277176
48Metabolic acidosis (HP:0001942)2.70798992
49Osteomalacia (HP:0002749)2.69264175
50Acanthocytosis (HP:0001927)2.62898928
51Abnormality of purine metabolism (HP:0004352)2.61729637
52Vascular calcification (HP:0004934)2.58812545
53Recurrent gram-negative bacterial infections (HP:0005420)2.56195542
54Lethargy (HP:0001254)2.54651977
55Hypoglycemic seizures (HP:0002173)2.52617618
56Glomerulonephritis (HP:0000099)2.52034809
57Abnormal gallbladder morphology (HP:0012437)2.51520536
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50919075
59Dicarboxylic aciduria (HP:0003215)2.50919075
60Mitral stenosis (HP:0001718)2.47548111
61Cholelithiasis (HP:0001081)2.45885990
62Arthropathy (HP:0003040)2.43042962
63Amyloidosis (HP:0011034)2.42874407
64Spastic diplegia (HP:0001264)2.42097972
65Gout (HP:0001997)2.39499276
66Gingival bleeding (HP:0000225)2.38060613
67Cerebral edema (HP:0002181)2.37316178
68Neonatal onset (HP:0003623)2.36062975
69Abnormal gallbladder physiology (HP:0012438)2.34463100
70Cholecystitis (HP:0001082)2.34463100
71Irritability (HP:0000737)2.31875695
72Cardiovascular calcification (HP:0011915)2.29488978
73Pulmonary embolism (HP:0002204)2.28258521
74Malnutrition (HP:0004395)2.26522436
75Fair hair (HP:0002286)2.22497641
76Esophageal varix (HP:0002040)2.22099647
77Menorrhagia (HP:0000132)2.21510847
78Thrombophlebitis (HP:0004418)2.20234833
79Sensorimotor neuropathy (HP:0007141)2.16068274
80Pancreatitis (HP:0001733)2.13511619
81Poikilocytosis (HP:0004447)2.11558776
82Enlarged kidneys (HP:0000105)2.10575366
83Late onset (HP:0003584)2.09907529
84Hemorrhage of the eye (HP:0011885)2.08722806
85Brushfield spots (HP:0001088)2.07765429
86Hyperinsulinemic hypoglycemia (HP:0000825)2.05190545
87Abnormality of the gallbladder (HP:0005264)2.03943865
88Vomiting (HP:0002013)2.03712612
89Opisthotonus (HP:0002179)2.02257640
90Generalized aminoaciduria (HP:0002909)1.97571408
91Hyperphosphaturia (HP:0003109)1.96443340
92Abnormality of iron homeostasis (HP:0011031)1.96155067
93Abnormality of transition element cation homeostasis (HP:0011030)1.93094907
94Rickets (HP:0002748)1.91422050
95Hypophosphatemic rickets (HP:0004912)1.88932804
96Abnormality of the Achilles tendon (HP:0005109)1.86938725
97Joint swelling (HP:0001386)1.85359948
98Epistaxis (HP:0000421)1.85079421
99Increased serum pyruvate (HP:0003542)1.83169825
100Abnormal cartilage morphology (HP:0002763)1.82844976
101Reduced antithrombin III activity (HP:0001976)1.82658512
102Abnormal enzyme/coenzyme activity (HP:0012379)1.81855076
103Potter facies (HP:0002009)1.81798283
104Facial shape deformation (HP:0011334)1.81798283
105Elevated hepatic transaminases (HP:0002910)1.81422051
106Renal cortical cysts (HP:0000803)1.80896863
107Abnormality of proline metabolism (HP:0010907)1.80282587
108Hydroxyprolinuria (HP:0003080)1.80282587
109Glycosuria (HP:0003076)1.79913628
110Abnormality of urine glucose concentration (HP:0011016)1.79913628
111Nephritis (HP:0000123)1.78880912
112Status epilepticus (HP:0002133)1.78055405
113Abnormal tarsal ossification (HP:0008369)1.76541914
114Reticulocytosis (HP:0001923)1.74914535
115Hyperglycemia (HP:0003074)1.74189409
116Alkalosis (HP:0001948)1.73272777
117Bifid scrotum (HP:0000048)1.72697915
118Elevated alkaline phosphatase (HP:0003155)1.71718227
119Neonatal hypoglycemia (HP:0001998)1.67931139
120Abnormal urine phosphate concentration (HP:0012599)1.63860469
121Hypothermia (HP:0002045)1.62285920
122Gangrene (HP:0100758)1.61750010
123Abnormality of alkaline phosphatase activity (HP:0004379)1.60744606
124Increased serum ferritin (HP:0003281)1.60035781
125Abnormality of glycolysis (HP:0004366)1.59819967
126Abnormality of vitamin metabolism (HP:0100508)1.58395834
127Abnormality of carpal bone ossification (HP:0006257)1.58027443
128Increased mean platelet volume (HP:0011877)1.53407650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.02848483
2FGFR44.77013732
3SIK14.55167221
4ERN14.53736799
5TAOK33.23934326
6ERBB43.17349320
7INSRR2.98511188
8WNK42.84639082
9MAP2K42.31725805
10CDK122.28613305
11MST1R2.10619524
12PKN22.08507715
13MAPK112.00754374
14PIK3CG1.89242213
15FLT31.83022864
16AKT31.79934074
17TYK21.77817640
18NTRK31.77226020
19TRIB31.75601511
20DAPK21.66915118
21LATS11.64527076
22PTK61.54660244
23FGFR11.48593238
24NLK1.46079799
25ABL21.43050878
26NEK91.41561794
27PDGFRA1.38268586
28FGFR21.36760088
29MAP3K21.33273689
30KDR1.33148023
31JAK21.29409524
32FRK1.26972448
33MAP3K71.20080412
34ERBB21.12263311
35TYRO31.12083709
36PRKAA21.08998644
37JAK11.05625368
38GRK61.04720911
39PINK11.04542299
40MAP2K31.04478811
41TBK11.04429912
42WNK11.04108537
43MAP3K101.03301625
44WNK31.02284217
45MAP3K140.97309156
46MAPK40.96605269
47EPHB10.91534265
48MAPK150.90277527
49PRKCZ0.89578596
50MET0.86529049
51EPHA30.85388107
52SGK10.83343364
53SIK20.80422731
54CDK60.80210091
55MAPK120.79535179
56STK38L0.79316156
57MAP3K30.78517115
58TIE10.77885651
59MAP3K110.76530624
60PRKACG0.76360594
61FER0.73746152
62CAMK2G0.73738989
63DDR20.72693759
64CSNK1E0.72309427
65DYRK1B0.70703096
66MAPKAPK30.69783442
67STK160.69079375
68CSK0.68585502
69PRKG10.67788781
70CDC42BPA0.66766320
71PRKAA10.65015530
72GSK3A0.64699227
73CAMK1D0.64456629
74EIF2AK10.64238106
75MAP2K60.63034867
76RPS6KB10.61154743
77SGK30.60270153
78BCR0.59811774
79RIPK10.59179229
80FGFR30.59152542
81TGFBR20.57360250
82PTK20.56965720
83CSNK1D0.56652428
84MAPK70.55973913
85IRAK30.55654462
86CSF1R0.54992436
87PRKACA0.54383598
88IKBKE0.53662203
89PKN10.53166841
90EPHA40.50481312
91PDPK10.49980978
92PRKCQ0.49444615
93TAOK20.46371838
94RPS6KA30.45960983
95GRK10.44996684
96SRC0.43853234
97SGK20.43522171
98CSNK1G10.43293680
99IGF1R0.43053408
100MAP3K130.42539457
101MAP3K50.42255936
102RET0.41747390
103MAP2K10.40697025
104CDK40.40564496
105PRKCG0.40312349
106ICK0.39952631
107EEF2K0.38504661
108CSNK2A20.36474819
109FGR0.36377886
110EGFR0.36211037
111PRKCB0.36070678
112MTOR0.35913373
113STK390.35445504
114CDK70.35352705
115CAMKK20.35071158
116PBK0.33955856
117MAP3K60.33326701
118CSNK2A10.33141646
119BRSK20.33109723
120MAP3K10.32515904
121CAMK40.32228930
122SGK4940.30756537
123SGK2230.30756537
124PDK10.30115157
125LATS20.26606167
126KSR20.26143294
127PRKCA0.25762457
128PIK3CA0.22896618
129CSNK1G20.22882081
130PAK30.22652466
131IRAK10.22453728
132TNK20.21589378
133ABL10.21547236
134CAMK1G0.20630202
135BMX0.20561450
136MAPK10.20450506
137CSNK1G30.19861038
138PDK20.19843865
139PRKACB0.18688384
140MAPK30.18628309

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.63091105
2Nitrogen metabolism_Homo sapiens_hsa009103.62728805
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37943904
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28380726
5Arginine biosynthesis_Homo sapiens_hsa002203.06819941
6* Complement and coagulation cascades_Homo sapiens_hsa046102.86534565
7Tryptophan metabolism_Homo sapiens_hsa003802.70277032
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66133833
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64973240
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55938374
11Fatty acid degradation_Homo sapiens_hsa000712.46507412
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36292955
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18941993
14Butanoate metabolism_Homo sapiens_hsa006502.14612259
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10551510
16Peroxisome_Homo sapiens_hsa041462.06942898
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.93857872
18Chemical carcinogenesis_Homo sapiens_hsa052041.92862047
19Histidine metabolism_Homo sapiens_hsa003401.90697829
20Propanoate metabolism_Homo sapiens_hsa006401.89431727
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89128567
22PPAR signaling pathway_Homo sapiens_hsa033201.85805859
23Staphylococcus aureus infection_Homo sapiens_hsa051501.85364046
24Fatty acid metabolism_Homo sapiens_hsa012121.78884067
25Caffeine metabolism_Homo sapiens_hsa002321.77714074
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.75823876
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73237551
28Retinol metabolism_Homo sapiens_hsa008301.69003180
29beta-Alanine metabolism_Homo sapiens_hsa004101.67459199
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62727032
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61166521
32Selenocompound metabolism_Homo sapiens_hsa004501.59101331
33Phenylalanine metabolism_Homo sapiens_hsa003601.55436511
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49720856
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49587069
36Bile secretion_Homo sapiens_hsa049761.49077773
37Tyrosine metabolism_Homo sapiens_hsa003501.45990358
38Pyruvate metabolism_Homo sapiens_hsa006201.33748645
39Sulfur metabolism_Homo sapiens_hsa009201.33058723
40Fatty acid elongation_Homo sapiens_hsa000621.31569841
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30159524
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26519724
43Steroid biosynthesis_Homo sapiens_hsa001001.22102685
44ABC transporters_Homo sapiens_hsa020101.21975056
45Folate biosynthesis_Homo sapiens_hsa007901.20646722
46Fat digestion and absorption_Homo sapiens_hsa049751.19680888
47Biosynthesis of amino acids_Homo sapiens_hsa012301.18529552
48Carbon metabolism_Homo sapiens_hsa012001.11154655
49Vitamin B6 metabolism_Homo sapiens_hsa007501.04513434
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.03461922
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00677581
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98429022
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.97387360
54Sulfur relay system_Homo sapiens_hsa041220.96053331
55Arginine and proline metabolism_Homo sapiens_hsa003300.94936293
56Vitamin digestion and absorption_Homo sapiens_hsa049770.87061794
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86864609
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82055391
59Lysine degradation_Homo sapiens_hsa003100.79995314
60One carbon pool by folate_Homo sapiens_hsa006700.78587729
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68649764
62Glycerolipid metabolism_Homo sapiens_hsa005610.65789192
63Glutathione metabolism_Homo sapiens_hsa004800.62635070
64Pentose phosphate pathway_Homo sapiens_hsa000300.56228667
65Fatty acid biosynthesis_Homo sapiens_hsa000610.52237587
66Metabolic pathways_Homo sapiens_hsa011000.45387782
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44631141
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43542367
69Prion diseases_Homo sapiens_hsa050200.43235960
70Pertussis_Homo sapiens_hsa051330.41844110
71Other glycan degradation_Homo sapiens_hsa005110.35905446
72Galactose metabolism_Homo sapiens_hsa000520.26847758
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26533629
74Insulin resistance_Homo sapiens_hsa049310.23416611
75Linoleic acid metabolism_Homo sapiens_hsa005910.22819525
76Fructose and mannose metabolism_Homo sapiens_hsa000510.22306471
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.21723722
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19688669
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.15893784
80Glucagon signaling pathway_Homo sapiens_hsa049220.10493422
81Mineral absorption_Homo sapiens_hsa049780.10446854
82AMPK signaling pathway_Homo sapiens_hsa041520.01401571
83N-Glycan biosynthesis_Homo sapiens_hsa005100.00558879
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2413937
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2392265
86Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2298598
87Amoebiasis_Homo sapiens_hsa05146-0.2181324
88Bladder cancer_Homo sapiens_hsa05219-0.2158188
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2062566
90Protein digestion and absorption_Homo sapiens_hsa04974-0.2015437
91Renin-angiotensin system_Homo sapiens_hsa04614-0.1937403
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1924188
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1880740
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1793727
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1727080
96Type II diabetes mellitus_Homo sapiens_hsa04930-0.1695558
97Hepatitis C_Homo sapiens_hsa05160-0.1645173
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1559669
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1449566
100Regulation of autophagy_Homo sapiens_hsa04140-0.1414168
101African trypanosomiasis_Homo sapiens_hsa05143-0.1209209
102Serotonergic synapse_Homo sapiens_hsa04726-0.1204850
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1031374
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0872078
105Circadian rhythm_Homo sapiens_hsa04710-0.0866591
106Sphingolipid metabolism_Homo sapiens_hsa00600-0.0719488
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0707709
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0678013
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0544461
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0520091

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