F13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.09488112
2omega-hydroxylase P450 pathway (GO:0097267)7.75657424
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.59825909
4L-phenylalanine catabolic process (GO:0006559)7.59825909
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26202924
6L-phenylalanine metabolic process (GO:0006558)7.26202924
7aromatic amino acid family catabolic process (GO:0009074)6.87784288
8tryptophan catabolic process (GO:0006569)6.22531421
9indole-containing compound catabolic process (GO:0042436)6.22531421
10indolalkylamine catabolic process (GO:0046218)6.22531421
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.16418913
12kynurenine metabolic process (GO:0070189)6.06572881
13drug metabolic process (GO:0017144)5.99331462
14bile acid biosynthetic process (GO:0006699)5.98121532
15glyoxylate metabolic process (GO:0046487)5.94691496
16tryptophan metabolic process (GO:0006568)5.87043761
17oxidative demethylation (GO:0070989)5.72920159
18urea cycle (GO:0000050)5.65240768
19urea metabolic process (GO:0019627)5.65240768
20negative regulation of fibrinolysis (GO:0051918)5.54748259
21alpha-linolenic acid metabolic process (GO:0036109)5.52362795
22cysteine metabolic process (GO:0006534)5.50293951
23high-density lipoprotein particle remodeling (GO:0034375)5.40807496
24sulfur amino acid catabolic process (GO:0000098)5.35563191
25regulation of fibrinolysis (GO:0051917)5.34148697
26complement activation, alternative pathway (GO:0006957)5.31865032
27peptidyl-glutamic acid carboxylation (GO:0017187)5.29616052
28protein carboxylation (GO:0018214)5.29616052
29regulation of protein activation cascade (GO:2000257)5.28614357
30nitrogen cycle metabolic process (GO:0071941)5.20076659
31serine family amino acid catabolic process (GO:0009071)5.19452861
32ethanol metabolic process (GO:0006067)5.14512319
33bile acid metabolic process (GO:0008206)5.09538451
34regulation of plasminogen activation (GO:0010755)5.08434586
35phenylpropanoid metabolic process (GO:0009698)5.03935880
36negative regulation of protein activation cascade (GO:2000258)5.01437083
37aromatic amino acid family metabolic process (GO:0009072)5.00067881
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.98235125
39homocysteine metabolic process (GO:0050667)4.97235837
40negative regulation of hemostasis (GO:1900047)4.95008026
41negative regulation of blood coagulation (GO:0030195)4.95008026
42regulation of complement activation (GO:0030449)4.93773327
43lysine metabolic process (GO:0006553)4.88793884
44lysine catabolic process (GO:0006554)4.88793884
45tyrosine metabolic process (GO:0006570)4.79146693
46reverse cholesterol transport (GO:0043691)4.73830697
47regulation of triglyceride catabolic process (GO:0010896)4.71699170
48amino-acid betaine metabolic process (GO:0006577)4.71439978
49alpha-amino acid catabolic process (GO:1901606)4.70164985
50hormone catabolic process (GO:0042447)4.69676794
51regulation of cholesterol esterification (GO:0010872)4.69510610
52regulation of humoral immune response (GO:0002920)4.68054575
53protein-lipid complex remodeling (GO:0034368)4.66437473
54macromolecular complex remodeling (GO:0034367)4.66437473
55plasma lipoprotein particle remodeling (GO:0034369)4.66437473
56positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.59455134
57negative regulation of wound healing (GO:0061045)4.53259546
58cellular ketone body metabolic process (GO:0046950)4.53097483
59acylglycerol homeostasis (GO:0055090)4.52978891
60triglyceride homeostasis (GO:0070328)4.52978891
61negative regulation of coagulation (GO:0050819)4.49556333
62negative regulation of sterol transport (GO:0032372)4.49407489
63negative regulation of cholesterol transport (GO:0032375)4.49407489
64glycine metabolic process (GO:0006544)4.45332956
65acute-phase response (GO:0006953)4.45050284
66S-adenosylmethionine metabolic process (GO:0046500)4.43687425
67indolalkylamine metabolic process (GO:0006586)4.41923422
68phospholipid efflux (GO:0033700)4.40902113
69bile acid and bile salt transport (GO:0015721)4.37246527
70cellular amino acid catabolic process (GO:0009063)4.34196304
71cellular glucuronidation (GO:0052695)4.31130480
72coenzyme catabolic process (GO:0009109)4.31129266
73amine catabolic process (GO:0009310)4.30527903
74cellular biogenic amine catabolic process (GO:0042402)4.30527903
75plasma lipoprotein particle clearance (GO:0034381)4.30216035
76glutamate metabolic process (GO:0006536)4.29747757
77serine family amino acid metabolic process (GO:0009069)4.29624731
78polyketide metabolic process (GO:0030638)4.26955418
79doxorubicin metabolic process (GO:0044598)4.26955418
80daunorubicin metabolic process (GO:0044597)4.26955418
81imidazole-containing compound metabolic process (GO:0052803)4.26041124
82alkaloid metabolic process (GO:0009820)4.23113430
83positive regulation of blood coagulation (GO:0030194)4.19400174
84positive regulation of hemostasis (GO:1900048)4.19400174
85benzene-containing compound metabolic process (GO:0042537)4.16513743
86cellular modified amino acid catabolic process (GO:0042219)4.14580621
87drug catabolic process (GO:0042737)4.14063678
88cholesterol efflux (GO:0033344)4.11532420
89ethanol oxidation (GO:0006069)4.11166239
90serine family amino acid biosynthetic process (GO:0009070)4.10369179
91flavonoid metabolic process (GO:0009812)4.09879952
92dicarboxylic acid biosynthetic process (GO:0043650)4.07590715
93aldehyde catabolic process (GO:0046185)4.05164575
94arginine metabolic process (GO:0006525)3.98910439
95negative regulation of complement activation (GO:0045916)3.98451288
96low-density lipoprotein particle remodeling (GO:0034374)3.96916603
97fibrinolysis (GO:0042730)3.95561472
98ketone body metabolic process (GO:1902224)3.92257439
99plasma lipoprotein particle assembly (GO:0034377)3.90789541
100intestinal cholesterol absorption (GO:0030299)3.90244961
101heme transport (GO:0015886)3.87037172
102positive regulation of coagulation (GO:0050820)3.86727481
103glucuronate metabolic process (GO:0019585)3.85442650
104uronic acid metabolic process (GO:0006063)3.85442650
105aminoglycoside antibiotic metabolic process (GO:0030647)3.84106593
106fat-soluble vitamin biosynthetic process (GO:0042362)3.83667724
107short-chain fatty acid metabolic process (GO:0046459)3.83260701
108opsonization (GO:0008228)3.81080703
109organic acid catabolic process (GO:0016054)3.80596750
110carboxylic acid catabolic process (GO:0046395)3.80596750
111blood coagulation, intrinsic pathway (GO:0007597)3.80240131
112acetyl-CoA metabolic process (GO:0006084)3.77481804
113steroid catabolic process (GO:0006706)3.75439910
114phospholipid homeostasis (GO:0055091)3.74814929
115regulation of bile acid biosynthetic process (GO:0070857)3.73441275
116cofactor catabolic process (GO:0051187)3.72886147
117primary alcohol catabolic process (GO:0034310)3.72778432
118killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.71811324
119disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.71811324
120cholesterol homeostasis (GO:0042632)3.71205728
121urate metabolic process (GO:0046415)3.70545190
122positive regulation of lipid catabolic process (GO:0050996)3.69685474
123complement activation, classical pathway (GO:0006958)3.69146173
124complement activation (GO:0006956)3.67754741
125positive regulation of lipoprotein lipase activity (GO:0051006)3.67426232
126positive regulation of triglyceride lipase activity (GO:0061365)3.67426232
127very-low-density lipoprotein particle assembly (GO:0034379)3.66491952
128protein activation cascade (GO:0072376)3.66395208
129sterol homeostasis (GO:0055092)3.65868379
130drug transmembrane transport (GO:0006855)3.65129628
131sodium-independent organic anion transport (GO:0043252)3.64769815
132response to mercury ion (GO:0046689)3.62969480
133aspartate family amino acid catabolic process (GO:0009068)3.61696459
134exogenous drug catabolic process (GO:0042738)3.61166889
135xenobiotic metabolic process (GO:0006805)3.61036661
136cytolysis (GO:0019835)3.60840989
137negative regulation of lipase activity (GO:0060192)3.60839922
138regulation of cholesterol homeostasis (GO:2000188)3.60538958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.39227117
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18221743
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.01415434
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51683206
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.22910115
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05568299
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79237731
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03826727
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00696835
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10236129
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03515074
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9393389
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98771347
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.63342716
15CLOCK_20551151_ChIP-Seq_293T_Human1.58451476
16HTT_18923047_ChIP-ChIP_STHdh_Human1.54796512
17GATA1_22025678_ChIP-Seq_K562_Human1.43232833
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42848127
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27104431
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20043781
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19792695
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18598543
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.15437823
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10764058
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05845226
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03067689
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00896403
28* NFE2_27457419_Chip-Seq_LIVER_Mouse1.00728593
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98384644
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96832811
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94548282
32* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92969342
33* HNFA_21074721_ChIP-Seq_CACO-2_Human0.92542871
34* PHF8_20622853_ChIP-Seq_HELA_Human0.87729659
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85794543
36* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85242666
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84748342
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84187341
39AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84019734
40GATA4_25053715_ChIP-Seq_YYC3_Human0.83787171
41IRF8_22096565_ChIP-ChIP_GC-B_Human0.83494047
42* EZH2_27294783_Chip-Seq_NPCs_Mouse0.82875992
43IRF1_19129219_ChIP-ChIP_H3396_Human0.81233328
44* GATA6_21074721_ChIP-Seq_CACO-2_Human0.80877729
45NFYA_21822215_ChIP-Seq_K562_Human0.80757342
46PIAS1_25552417_ChIP-Seq_VCAP_Human0.80034893
47TP53_18474530_ChIP-ChIP_U2OS_Human0.79464188
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78674641
49KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78048254
50TCF4_18268006_ChIP-ChIP_LS174T_Human0.76883641
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76134936
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74868218
53* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74728199
54* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73764681
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73382691
56ZNF263_19887448_ChIP-Seq_K562_Human0.73119710
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72508032
58RARA_24833708_ChIP-Seq_LIVER_Mouse0.72093857
59SOX2_21211035_ChIP-Seq_LN229_Human0.71960598
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70595441
61ER_23166858_ChIP-Seq_MCF-7_Human0.70209067
62SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69832673
63ESR2_21235772_ChIP-Seq_MCF-7_Human0.69694210
64* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68548888
65* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.67960731
66NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67576143
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67576143
68* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67518208
69* CRX_20693478_ChIP-Seq_RETINA_Mouse0.66551157
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65516050
71PCGF2_27294783_Chip-Seq_NPCs_Mouse0.61988373
72IGF1R_20145208_ChIP-Seq_DFB_Human0.61725536
73RARB_24833708_ChIP-Seq_LIVER_Mouse0.61502322
74* ETV1_20927104_ChIP-Seq_GIST48_Human0.61417292
75RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61152057
76* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.60890131
77BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60806705
78* OCT4_18555785_Chip-Seq_ESCs_Mouse0.59890328
79* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.59809293
80* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59547751
81* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.59272036
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59056268
83EGR1_19032775_ChIP-ChIP_M12_Human0.58778889
84SOX2_20726797_ChIP-Seq_SW620_Human0.58616932
85CEBPB_22108803_ChIP-Seq_LS180_Human0.58533395
86* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.57529039
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57012021
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.56748818
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.56268572
90* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.55927673
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.54581315
92* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.54526448
93FOXA1_25552417_ChIP-Seq_VCAP_Human0.54202136
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53906947
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.53563464
96AR_20517297_ChIP-Seq_VCAP_Human0.53549047
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.53447209
98* PU1_27457419_Chip-Seq_LIVER_Mouse0.53216318
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.53157147
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52239489
101RAC3_21632823_ChIP-Seq_H3396_Human0.52095452
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.51828606
103* NFYB_21822215_ChIP-Seq_K562_Human0.51465627
104LXR_22292898_ChIP-Seq_THP-1_Human0.51394377
105TAF15_26573619_Chip-Seq_HEK293_Human0.51043364
106* MYC_19915707_ChIP-ChIP_AK7_Human0.50738144
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50515357
108ESET_19884257_ChIP-Seq_ESCs_Mouse0.50358090
109CBP_21632823_ChIP-Seq_H3396_Human0.50320920
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50254831
111STAT1_17558387_ChIP-Seq_HELA_Human0.49812443
112* SPI1_20517297_ChIP-Seq_HL60_Human0.49275242
113KLF5_20875108_ChIP-Seq_MESCs_Mouse0.49105720
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.48924191
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46092557
116P53_21459846_ChIP-Seq_SAOS-2_Human0.45556434
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.44539101
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43865633
119GATA1_19941826_ChIP-Seq_K562_Human0.43248972
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43186145
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43108523
122TAF2_19829295_ChIP-Seq_ESCs_Human0.42596270
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42065299
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.41742606
125GATA6_25053715_ChIP-Seq_YYC3_Human0.41405727
126GATA2_19941826_ChIP-Seq_K562_Human0.41083968
127BCAT_22108803_ChIP-Seq_LS180_Human0.40843925
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.39810605
129* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39349753
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.39274399
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.39253500
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38376537
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37407362
134LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36124218
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.35859312
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.35377061
137* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35195622
138NCOR_22424771_ChIP-Seq_293T_Human0.34814495
139ERG_20517297_ChIP-Seq_VCAP_Human0.34447870
140* CDX2_22108803_ChIP-Seq_LS180_Human0.34033418
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.34020037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25973597
2MP0005360_urolithiasis7.74721480
3MP0005085_abnormal_gallbladder_physiolo6.40258830
4MP0005365_abnormal_bile_salt6.11944035
5MP0008875_abnormal_xenobiotic_pharmacok5.12495126
6MP0003806_abnormal_nucleotide_metabolis4.25121173
7MP0003252_abnormal_bile_duct3.94884047
8MP0010329_abnormal_lipoprotein_level3.52041231
9MP0009840_abnormal_foam_cell3.11128744
10MP0005083_abnormal_biliary_tract3.00562150
11MP0003195_calcinosis2.95025965
12MP0005332_abnormal_amino_acid2.90956805
13MP0001666_abnormal_nutrient_absorption2.55458018
14MP0004019_abnormal_vitamin_homeostasis2.31448767
15MP0003191_abnormal_cellular_cholesterol2.22525824
16MP0000609_abnormal_liver_physiology2.13403231
17MP0002138_abnormal_hepatobiliary_system2.09805434
18MP0002118_abnormal_lipid_homeostasis2.07380618
19MP0003868_abnormal_feces_composition1.88808809
20MP0005319_abnormal_enzyme/_coenzyme1.83842018
21MP0001764_abnormal_homeostasis1.69620038
22MP0005584_abnormal_enzyme/coenzyme_acti1.59989835
23MP0009697_abnormal_copulation1.56857461
24MP0005451_abnormal_body_composition1.43699173
25MP0009643_abnormal_urine_homeostasis1.37509513
26MP0003186_abnormal_redox_activity1.31896933
27MP0003011_delayed_dark_adaptation1.31341535
28MP0003656_abnormal_erythrocyte_physiolo1.21927786
29MP0000598_abnormal_liver_morphology1.17203835
30MP0005647_abnormal_sex_gland1.10169644
31MP0003705_abnormal_hypodermis_morpholog1.09077788
32MP0000604_amyloidosis1.05474956
33MP0009764_decreased_sensitivity_to1.05327572
34MP0005636_abnormal_mineral_homeostasis1.04288090
35MP0002132_abnormal_respiratory_system1.03068259
36MP0009763_increased_sensitivity_to0.99730969
37MP0002254_reproductive_system_inflammat0.98832037
38MP0010368_abnormal_lymphatic_system0.91719593
39MP0001915_intracranial_hemorrhage0.91146566
40MP0008469_abnormal_protein_level0.88710428
41MP0009642_abnormal_blood_homeostasis0.87696641
42MP0005408_hypopigmentation0.87597302
43MP0006036_abnormal_mitochondrial_physio0.85813689
44MP0005084_abnormal_gallbladder_morpholo0.83974489
45MP0005187_abnormal_penis_morphology0.83224742
46MP0005670_abnormal_white_adipose0.81936939
47MP0002876_abnormal_thyroid_physiology0.79320814
48MP0005376_homeostasis/metabolism_phenot0.79173458
49MP0009765_abnormal_xenobiotic_induced0.77340936
50MP0002078_abnormal_glucose_homeostasis0.77254341
51MP0005220_abnormal_exocrine_pancreas0.74792218
52MP0001756_abnormal_urination0.71241689
53MP0001661_extended_life_span0.70658443
54MP0005535_abnormal_body_temperature0.70372152
55MP0002971_abnormal_brown_adipose0.70060704
56MP0003879_abnormal_hair_cell0.69427012
57MP0004130_abnormal_muscle_cell0.67852626
58MP0005334_abnormal_fat_pad0.66449663
59MP0003690_abnormal_glial_cell0.65665729
60MP0002282_abnormal_trachea_morphology0.64471943
61MP0005266_abnormal_metabolism0.63899413
62MP0009053_abnormal_anal_canal0.63440418
63MP0003329_amyloid_beta_deposits0.62336495
64MP0006035_abnormal_mitochondrial_morpho0.57729036
65MP0000639_abnormal_adrenal_gland0.57277890
66MP0002136_abnormal_kidney_physiology0.57208161
67MP0005023_abnormal_wound_healing0.52818428
68MP0002928_abnormal_bile_duct0.51680318
69MP0005448_abnormal_energy_balance0.51581562
70MP0002249_abnormal_larynx_morphology0.50469597
71MP0005464_abnormal_platelet_physiology0.49894139
72MP0005395_other_phenotype0.49605537
73MP0003638_abnormal_response/metabolism_0.47766151
74MP0009785_altered_susceptibility_to0.46000892
75MP0008874_decreased_physiological_sensi0.44311428
76MP0002822_catalepsy0.44059139
77MP0003718_maternal_effect0.43957216
78MP0005164_abnormal_response_to0.43582830
79MP0008873_increased_physiological_sensi0.43569963
80MP0004043_abnormal_pH_regulation0.42999525
81MP0003724_increased_susceptibility_to0.41476545
82MP0003953_abnormal_hormone_level0.40989027
83MP0004782_abnormal_surfactant_physiolog0.40944783
84MP0003075_altered_response_to0.40041294
85MP0002837_dystrophic_cardiac_calcinosis0.39905871
86MP0005666_abnormal_adipose_tissue0.39565526
87MP0003436_decreased_susceptibility_to0.38515305
88MP0009672_abnormal_birth_weight0.37831403
89MP0005166_decreased_susceptibility_to0.37688550
90MP0008872_abnormal_physiological_respon0.37263130
91MP0000230_abnormal_systemic_arterial0.36198462
92MP0003959_abnormal_lean_body0.36099490
93MP0005248_abnormal_Harderian_gland0.35630232
94MP0002168_other_aberrant_phenotype0.34757620
95MP0004381_abnormal_hair_follicle0.33097850
96MP0002796_impaired_skin_barrier0.32777913
97MP0000579_abnormal_nail_morphology0.31559698
98MP0009115_abnormal_fat_cell0.31261433
99MP0001765_abnormal_ion_homeostasis0.31180021
100MP0009384_cardiac_valve_regurgitation0.30764952
101MP0006082_CNS_inflammation0.30055730
102MP0005058_abnormal_lysosome_morphology0.29689389
103MP0000249_abnormal_blood_vessel0.29511645
104MP0001851_eye_inflammation0.28877199
105MP0000920_abnormal_myelination0.28751894
106MP0002970_abnormal_white_adipose0.28058616
107MP0001845_abnormal_inflammatory_respons0.28004236
108MP0001243_abnormal_dermal_layer0.27823140
109MP0004883_abnormal_blood_vessel0.27814293
110MP0001853_heart_inflammation0.27217449
111MP0005197_abnormal_uvea_morphology0.26660654
112MP0000566_synostosis0.26473673
113MP0000467_abnormal_esophagus_morphology0.26239656
114MP0002135_abnormal_kidney_morphology0.25874863
115MP0001881_abnormal_mammary_gland0.25661311
116MP0002089_abnormal_postnatal_growth/wei0.24331448
117MP0003632_abnormal_nervous_system0.23615602
118MP0003633_abnormal_nervous_system0.23018514
119MP0004272_abnormal_basement_membrane0.20294651
120MP0003631_nervous_system_phenotype0.19315732
121MP0001545_abnormal_hematopoietic_system0.19072134
122MP0005397_hematopoietic_system_phenotyp0.19072134
123MP0002128_abnormal_blood_circulation0.18015728

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.32410454
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31310717
3Intrahepatic cholestasis (HP:0001406)7.29013859
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.55774914
5Prolonged partial thromboplastin time (HP:0003645)6.45786797
6Hypobetalipoproteinemia (HP:0003563)6.29585613
7Xanthomatosis (HP:0000991)6.26382716
8Hyperlipoproteinemia (HP:0010980)5.36470001
9Complement deficiency (HP:0004431)5.30279293
10Joint hemorrhage (HP:0005261)4.75562470
11Hypolipoproteinemia (HP:0010981)4.69210002
12Hyperammonemia (HP:0001987)4.66776429
13Hyperglycinemia (HP:0002154)4.51695611
14Epidermoid cyst (HP:0200040)4.47420688
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39047232
16Nephritis (HP:0000123)4.37620022
17Ketosis (HP:0001946)4.35547770
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.29730970
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.27183481
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22939190
21Abnormality of methionine metabolism (HP:0010901)4.21122124
22Hyperglycinuria (HP:0003108)4.15597815
23Fat malabsorption (HP:0002630)4.11939465
24Abnormality of serine family amino acid metabolism (HP:0010894)4.09910518
25Abnormality of glycine metabolism (HP:0010895)4.09910518
26Hypoalphalipoproteinemia (HP:0003233)4.06347380
27* Abnormality of the common coagulation pathway (HP:0010990)3.92407065
28Abnormality of complement system (HP:0005339)3.85440713
29Hypoglycemic coma (HP:0001325)3.84557100
30Abnormality of pyrimidine metabolism (HP:0004353)3.82130192
31Conjugated hyperbilirubinemia (HP:0002908)3.72589539
32Abnormality of the intrinsic pathway (HP:0010989)3.70460955
33Hypercholesterolemia (HP:0003124)3.56323407
34Abnormality of fatty-acid metabolism (HP:0004359)3.42047462
35Hyperbilirubinemia (HP:0002904)3.33905013
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30290815
37Delayed CNS myelination (HP:0002188)3.21597437
38Abnormality of nucleobase metabolism (HP:0010932)3.20067653
39Ketoacidosis (HP:0001993)3.19824851
40Abnormality of serum amino acid levels (HP:0003112)3.13837734
41Steatorrhea (HP:0002570)3.07174255
42Hepatocellular carcinoma (HP:0001402)3.03205653
43Spontaneous abortion (HP:0005268)2.93552468
44Abnormality of purine metabolism (HP:0004352)2.89036384
45Osteomalacia (HP:0002749)2.89018189
46Hypochromic microcytic anemia (HP:0004840)2.87606818
47Gout (HP:0001997)2.85475224
48Myocardial infarction (HP:0001658)2.84462602
49Metabolic acidosis (HP:0001942)2.82855178
50Skin nodule (HP:0200036)2.75779835
51Systemic lupus erythematosus (HP:0002725)2.68732931
52Lethargy (HP:0001254)2.67550726
53Vascular calcification (HP:0004934)2.67132056
54Purpura (HP:0000979)2.66560418
55Dicarboxylic aciduria (HP:0003215)2.64767837
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64767837
57Acanthocytosis (HP:0001927)2.58420575
58Reduced antithrombin III activity (HP:0001976)2.53731362
59Spastic diplegia (HP:0001264)2.50799451
60Cerebral edema (HP:0002181)2.47208299
61Pulmonary embolism (HP:0002204)2.46433017
62Fair hair (HP:0002286)2.45973088
63Glomerulonephritis (HP:0000099)2.45107455
64Hypoglycemic seizures (HP:0002173)2.44320738
65Irritability (HP:0000737)2.40620392
66Abnormal gallbladder morphology (HP:0012437)2.40055749
67Neonatal onset (HP:0003623)2.39705163
68Mitral stenosis (HP:0001718)2.37267429
69Cardiovascular calcification (HP:0011915)2.36809701
70Cholelithiasis (HP:0001081)2.33806887
71Malnutrition (HP:0004395)2.31399730
72Recurrent gram-negative bacterial infections (HP:0005420)2.31025545
73Generalized aminoaciduria (HP:0002909)2.26044323
74Abnormal gallbladder physiology (HP:0012438)2.25680210
75Cholecystitis (HP:0001082)2.25680210
76Enlarged kidneys (HP:0000105)2.20645032
77Hyperphosphaturia (HP:0003109)2.18293763
78Esophageal varix (HP:0002040)2.18237382
79Sensorimotor neuropathy (HP:0007141)2.17352387
80Amyloidosis (HP:0011034)2.17143975
81Pancreatitis (HP:0001733)2.16460680
82Vomiting (HP:0002013)2.15404638
83Alkalosis (HP:0001948)2.14004916
84Gingival bleeding (HP:0000225)2.13308445
85Arthropathy (HP:0003040)2.13279675
86Abnormality of vitamin metabolism (HP:0100508)2.13264633
87Menorrhagia (HP:0000132)2.10547585
88Late onset (HP:0003584)2.10113371
89Abnormality of the Achilles tendon (HP:0005109)2.09279191
90Neonatal hypoglycemia (HP:0001998)2.08157348
91Joint swelling (HP:0001386)2.07814754
92Elevated alkaline phosphatase (HP:0003155)2.06432857
93Thrombophlebitis (HP:0004418)2.06363747
94Brushfield spots (HP:0001088)2.05443285
95Rickets (HP:0002748)2.04906370
96Hydroxyprolinuria (HP:0003080)1.99447549
97Abnormality of proline metabolism (HP:0010907)1.99447549
98Opisthotonus (HP:0002179)1.99172168
99Proximal tubulopathy (HP:0000114)1.98789641
100Poikilocytosis (HP:0004447)1.98705903
101Hyperinsulinemic hypoglycemia (HP:0000825)1.97137984
102Abnormality of the gallbladder (HP:0005264)1.96090870
103Increased purine levels (HP:0004368)1.95338710
104Hyperuricemia (HP:0002149)1.95338710
105Hemorrhage of the eye (HP:0011885)1.92824234
106Abnormal enzyme/coenzyme activity (HP:0012379)1.92354956
107Abnormal cartilage morphology (HP:0002763)1.88533573
108Hypophosphatemic rickets (HP:0004912)1.88503795
109Bifid scrotum (HP:0000048)1.87620675
110Renal cortical cysts (HP:0000803)1.85778129
111Abnormality of alkaline phosphatase activity (HP:0004379)1.85691747
112Abnormality of transition element cation homeostasis (HP:0011030)1.85131102
113Abnormality of iron homeostasis (HP:0011031)1.84610527
114Increased serum ferritin (HP:0003281)1.83895907
115Abnormality of urine glucose concentration (HP:0011016)1.83431566
116Glycosuria (HP:0003076)1.83431566
117Epistaxis (HP:0000421)1.80287836
118Gangrene (HP:0100758)1.78881833
119Abnormal urine phosphate concentration (HP:0012599)1.78636564
120Increased mean platelet volume (HP:0011877)1.71687869
121Abnormal delivery (HP:0001787)1.71606495
122Abnormal biliary tract physiology (HP:0012439)1.69808477
123Bile duct proliferation (HP:0001408)1.69808477
124Generalized hypopigmentation of hair (HP:0011358)1.68525214
125Cerebral palsy (HP:0100021)1.66386795
126Abnormal platelet volume (HP:0011876)1.53837463
127Blue irides (HP:0000635)1.48313557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.26698678
2FGFR44.53357180
3SIK14.43914973
4ERN14.06796770
5INSRR3.05889709
6TAOK33.01041934
7ERBB42.90200817
8PIK3CA2.38457221
9MAP2K42.29718355
10MST1R2.26436567
11PKN22.21958834
12MAPK111.92739387
13FLT31.87788251
14PIK3CG1.81253427
15LATS11.67966940
16TYK21.66465427
17TRIB31.66062809
18DAPK21.52373095
19ABL21.51661514
20NTRK31.49546133
21PTK61.45494841
22FRK1.43524817
23NEK91.39634991
24FGFR21.38433022
25MAP3K21.38064125
26PRPF4B1.36841559
27KDR1.26892781
28MAP3K71.24304398
29JAK21.22998876
30PINK11.20977777
31PRKAA21.14909840
32STK38L1.11203189
33GRK61.10186586
34PRKG11.03607659
35ERBB21.01644474
36MAP2K31.01579225
37CAMKK20.98971704
38MAP3K140.98505473
39JAK10.98454403
40MAP3K100.98105775
41ZAP700.97959064
42MAPK40.96733056
43TBK10.95925753
44MAP3K120.94164325
45FER0.93893612
46PRKCZ0.92897872
47NLK0.91762725
48MET0.89211449
49MAP3K30.86393237
50EPHB10.85823623
51PRKACA0.84650535
52TIE10.82105009
53MAP3K10.80437259
54MAPK150.79192138
55MAPK120.78369405
56PDGFRA0.77206366
57CDK60.77119188
58PRKACG0.76992996
59SCYL20.75595874
60SGK30.75012498
61CSNK1E0.74850834
62CSNK1D0.74253703
63MYLK0.73371459
64GSK3A0.73176259
65TNK20.72359403
66PRKAA10.71296314
67DYRK1B0.70990213
68PRKCB0.70090707
69MAP3K110.69998854
70EPHA30.69887176
71CSK0.68198677
72CAMK1D0.67749982
73CAMK2G0.67298332
74SGK10.67288440
75WNK30.65000518
76RIPK10.63366565
77RPS6KA30.63313266
78TGFBR20.61911670
79MAP2K60.61295286
80AKT30.61068434
81ACVR1B0.60931815
82SGK20.60415307
83BRSK20.59581079
84STK380.58816198
85PRKACB0.58669032
86IRAK30.57309840
87PTK20.57102338
88FGFR30.56500148
89SGK2230.55398347
90SGK4940.55398347
91SRC0.54521394
92CSF1R0.54086575
93MAPK70.54056873
94WNK40.54015054
95EIF2AK10.53599550
96PDPK10.52895279
97PDK20.51631789
98PRKCQ0.50567247
99CSNK1G10.48897319
100IKBKE0.48455279
101NEK10.48195454
102RPS6KB10.47869172
103EPHA40.47433026
104CSNK2A10.45784417
105IGF1R0.45151713
106CDK120.45038286
107PDK30.45009030
108PDK40.45009030
109GRK10.44216851
110MAP3K50.42460355
111RET0.40993618
112TAOK20.40628791
113CSNK2A20.39973149
114KSR20.39811637
115PRKCG0.39807934
116OXSR10.38720360
117MAP2K10.38301327
118MAP3K130.38198133
119PKN10.37164711
120FGFR10.37008303
121CDK40.36575902
122CDK90.35551912
123PBK0.35350644
124MAP4K20.34982965
125MAP3K60.34849338
126PDK10.34581576
127MAPKAPK30.34425559
128MTOR0.33698113
129EGFR0.32768418
130ICK0.31087708
131CAMK40.29384407
132CSNK1G20.27004788
133IRAK20.26630184
134PRKCA0.26593832
135PAK30.25593396
136IRAK10.24593331
137CAMK1G0.23073871
138CSNK1G30.22043902
139LATS20.21134316

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45844944
2Nitrogen metabolism_Homo sapiens_hsa009103.63805832
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41300714
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38787324
5Arginine biosynthesis_Homo sapiens_hsa002203.03110462
6Tryptophan metabolism_Homo sapiens_hsa003802.69987720
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68258325
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65679694
9* Complement and coagulation cascades_Homo sapiens_hsa046102.64921557
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54493108
11Fatty acid degradation_Homo sapiens_hsa000712.50424910
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44345005
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30621723
14Butanoate metabolism_Homo sapiens_hsa006502.24156837
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11875622
16Peroxisome_Homo sapiens_hsa041462.10218849
17Propanoate metabolism_Homo sapiens_hsa006402.01129547
18Chemical carcinogenesis_Homo sapiens_hsa052041.91639184
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.91398606
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89302248
21Histidine metabolism_Homo sapiens_hsa003401.87909492
22PPAR signaling pathway_Homo sapiens_hsa033201.84069065
23Fatty acid metabolism_Homo sapiens_hsa012121.80993671
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.74684427
25beta-Alanine metabolism_Homo sapiens_hsa004101.74367387
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74119700
27Staphylococcus aureus infection_Homo sapiens_hsa051501.71296060
28Caffeine metabolism_Homo sapiens_hsa002321.70193620
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70139277
30Retinol metabolism_Homo sapiens_hsa008301.67287481
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66072836
32Selenocompound metabolism_Homo sapiens_hsa004501.58095380
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56878901
34Phenylalanine metabolism_Homo sapiens_hsa003601.56003829
35Bile secretion_Homo sapiens_hsa049761.50934343
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43319608
37Pyruvate metabolism_Homo sapiens_hsa006201.40852634
38Tyrosine metabolism_Homo sapiens_hsa003501.40262188
39Sulfur metabolism_Homo sapiens_hsa009201.36711534
40Fatty acid elongation_Homo sapiens_hsa000621.31171757
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.29663447
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29525067
43Biosynthesis of amino acids_Homo sapiens_hsa012301.20435103
44Folate biosynthesis_Homo sapiens_hsa007901.18361671
45ABC transporters_Homo sapiens_hsa020101.18185588
46Steroid biosynthesis_Homo sapiens_hsa001001.17700346
47Carbon metabolism_Homo sapiens_hsa012001.16041864
48Fat digestion and absorption_Homo sapiens_hsa049751.11096291
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.07834773
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07396775
51Arginine and proline metabolism_Homo sapiens_hsa003300.98630784
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.97972501
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96048240
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93966228
55Vitamin B6 metabolism_Homo sapiens_hsa007500.91591859
56Vitamin digestion and absorption_Homo sapiens_hsa049770.91015700
57Sulfur relay system_Homo sapiens_hsa041220.89807451
58Lysine degradation_Homo sapiens_hsa003100.84636888
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84495973
60One carbon pool by folate_Homo sapiens_hsa006700.73712603
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72488998
62Glutathione metabolism_Homo sapiens_hsa004800.68583979
63Glycerolipid metabolism_Homo sapiens_hsa005610.68343231
64Pentose phosphate pathway_Homo sapiens_hsa000300.57441082
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57417624
66Fatty acid biosynthesis_Homo sapiens_hsa000610.49953651
67Metabolic pathways_Homo sapiens_hsa011000.46404629
68Pertussis_Homo sapiens_hsa051330.34205986
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33673204
70Prion diseases_Homo sapiens_hsa050200.33185770
71Galactose metabolism_Homo sapiens_hsa000520.25057975
72Fructose and mannose metabolism_Homo sapiens_hsa000510.24653532
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23163143
74Insulin resistance_Homo sapiens_hsa049310.22363558
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21161442
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21131961
77Linoleic acid metabolism_Homo sapiens_hsa005910.18882673
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.12980174
79Glucagon signaling pathway_Homo sapiens_hsa049220.09016884
80Other glycan degradation_Homo sapiens_hsa005110.07216474
81AMPK signaling pathway_Homo sapiens_hsa041520.01536673
82Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2773842
83Ether lipid metabolism_Homo sapiens_hsa00565-0.2552967
84Bladder cancer_Homo sapiens_hsa05219-0.2500568
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2460556
86Amoebiasis_Homo sapiens_hsa05146-0.2434306
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2378974
88Type II diabetes mellitus_Homo sapiens_hsa04930-0.2301852
89Circadian rhythm_Homo sapiens_hsa04710-0.2272826
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2051388
91N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2001147
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1963398
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1902177
94Hepatitis C_Homo sapiens_hsa05160-0.1806737
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1707344
96African trypanosomiasis_Homo sapiens_hsa05143-0.1705246
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1663861
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1553614
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1446161
100Renin-angiotensin system_Homo sapiens_hsa04614-0.1437412
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1423540
102Regulation of autophagy_Homo sapiens_hsa04140-0.1393675
103Sphingolipid metabolism_Homo sapiens_hsa00600-0.1219778
104Mineral absorption_Homo sapiens_hsa04978-0.1135557
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1112605
106Insulin signaling pathway_Homo sapiens_hsa04910-0.1110161
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0925908
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0769721
109Serotonergic synapse_Homo sapiens_hsa04726-0.0471764
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0444680

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