F2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.57786733
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.57786733
3L-phenylalanine metabolic process (GO:0006558)7.25036636
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25036636
5aromatic amino acid family catabolic process (GO:0009074)6.80005971
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.51136130
7exogenous drug catabolic process (GO:0042738)6.31357128
8tryptophan catabolic process (GO:0006569)6.12453380
9indole-containing compound catabolic process (GO:0042436)6.12453380
10indolalkylamine catabolic process (GO:0046218)6.12453380
11kynurenine metabolic process (GO:0070189)6.02260934
12regulation of plasminogen activation (GO:0010755)6.01894435
13epoxygenase P450 pathway (GO:0019373)5.99842780
14bile acid biosynthetic process (GO:0006699)5.94684529
15glyoxylate metabolic process (GO:0046487)5.78907783
16tryptophan metabolic process (GO:0006568)5.77067140
17high-density lipoprotein particle remodeling (GO:0034375)5.75567796
18urea cycle (GO:0000050)5.72173044
19urea metabolic process (GO:0019627)5.72173044
20alpha-linolenic acid metabolic process (GO:0036109)5.65248458
21omega-hydroxylase P450 pathway (GO:0097267)5.48163393
22regulation of protein activation cascade (GO:2000257)5.41813155
23complement activation, alternative pathway (GO:0006957)5.37904315
24sulfur amino acid catabolic process (GO:0000098)5.35262143
25cysteine metabolic process (GO:0006534)5.35227089
26intestinal cholesterol absorption (GO:0030299)5.31330375
27* negative regulation of fibrinolysis (GO:0051918)5.29530151
28nitrogen cycle metabolic process (GO:0071941)5.25689356
29* regulation of fibrinolysis (GO:0051917)5.21371044
30serine family amino acid catabolic process (GO:0009071)5.13789867
31bile acid metabolic process (GO:0008206)5.10418284
32regulation of cholesterol esterification (GO:0010872)5.06321678
33reverse cholesterol transport (GO:0043691)5.05080238
34regulation of complement activation (GO:0030449)5.03685880
35* protein carboxylation (GO:0018214)5.02706693
36* peptidyl-glutamic acid carboxylation (GO:0017187)5.02706693
37aromatic amino acid family metabolic process (GO:0009072)4.94691654
38plasma lipoprotein particle remodeling (GO:0034369)4.93895568
39protein-lipid complex remodeling (GO:0034368)4.93895568
40macromolecular complex remodeling (GO:0034367)4.93895568
41regulation of triglyceride catabolic process (GO:0010896)4.91445008
42regulation of apoptotic cell clearance (GO:2000425)4.90446568
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87236163
44negative regulation of protein activation cascade (GO:2000258)4.85441983
45tyrosine metabolic process (GO:0006570)4.81654312
46homocysteine metabolic process (GO:0050667)4.76728205
47phospholipid efflux (GO:0033700)4.75172959
48protein-lipid complex subunit organization (GO:0071825)4.71579486
49acylglycerol homeostasis (GO:0055090)4.70119934
50triglyceride homeostasis (GO:0070328)4.70119934
51regulation of humoral immune response (GO:0002920)4.69338127
52negative regulation of sterol transport (GO:0032372)4.65434143
53negative regulation of cholesterol transport (GO:0032375)4.65434143
54alpha-amino acid catabolic process (GO:1901606)4.64322175
55amino-acid betaine metabolic process (GO:0006577)4.61964321
56* negative regulation of hemostasis (GO:1900047)4.60647369
57* negative regulation of blood coagulation (GO:0030195)4.60647369
58lysine metabolic process (GO:0006553)4.56134107
59lysine catabolic process (GO:0006554)4.56134107
60positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.54999757
61plasma lipoprotein particle clearance (GO:0034381)4.54359059
62cellular ketone body metabolic process (GO:0046950)4.49403246
63glycine metabolic process (GO:0006544)4.43807439
64bile acid and bile salt transport (GO:0015721)4.42439331
65cholesterol efflux (GO:0033344)4.37125461
66imidazole-containing compound metabolic process (GO:0052803)4.36747903
67indolalkylamine metabolic process (GO:0006586)4.34333124
68coenzyme catabolic process (GO:0009109)4.33918801
69drug metabolic process (GO:0017144)4.32159525
70* acute-phase response (GO:0006953)4.27973492
71cellular amino acid catabolic process (GO:0009063)4.26775391
72glutamate metabolic process (GO:0006536)4.25518137
73amine catabolic process (GO:0009310)4.25418730
74cellular biogenic amine catabolic process (GO:0042402)4.25418730
75cellular glucuronidation (GO:0052695)4.23205850
76* negative regulation of coagulation (GO:0050819)4.19693151
77serine family amino acid metabolic process (GO:0009069)4.18868105
78plasma lipoprotein particle assembly (GO:0034377)4.16540598
79low-density lipoprotein particle remodeling (GO:0034374)4.13646376
80benzene-containing compound metabolic process (GO:0042537)4.11111679
81* negative regulation of wound healing (GO:0061045)4.08672313
82ethanol metabolic process (GO:0006067)4.07039828
83ethanol oxidation (GO:0006069)4.06727875
84cellular modified amino acid catabolic process (GO:0042219)4.05830833
85* positive regulation of hemostasis (GO:1900048)4.05258325
86* positive regulation of blood coagulation (GO:0030194)4.05258325
87dicarboxylic acid biosynthetic process (GO:0043650)4.05140623
88arginine metabolic process (GO:0006525)4.04976150
89serine family amino acid biosynthetic process (GO:0009070)4.04020718
90oxidative demethylation (GO:0070989)4.02581438
91positive regulation of fatty acid biosynthetic process (GO:0045723)4.00457465
92aldehyde catabolic process (GO:0046185)4.00001543
93phenylpropanoid metabolic process (GO:0009698)3.92918145
94drug catabolic process (GO:0042737)3.90586706
95negative regulation of complement activation (GO:0045916)3.90034209
96positive regulation of triglyceride lipase activity (GO:0061365)3.89273523
97positive regulation of lipoprotein lipase activity (GO:0051006)3.89273523
98ketone body metabolic process (GO:1902224)3.89032162
99lipoprotein metabolic process (GO:0042157)3.85287384
100very-low-density lipoprotein particle assembly (GO:0034379)3.84849439
101phospholipid homeostasis (GO:0055091)3.84735689
102negative regulation of lipase activity (GO:0060192)3.84173952
103positive regulation of lipid catabolic process (GO:0050996)3.82073637
104cofactor catabolic process (GO:0051187)3.80964732
105cholesterol homeostasis (GO:0042632)3.80636503
106complement activation, classical pathway (GO:0006958)3.78432831
107proline metabolic process (GO:0006560)3.77197227
108plasma lipoprotein particle organization (GO:0071827)3.75575831
109complement activation (GO:0006956)3.75327104
110glucuronate metabolic process (GO:0019585)3.74967406
111uronic acid metabolic process (GO:0006063)3.74967406
112* fibrinolysis (GO:0042730)3.74775583
113sterol homeostasis (GO:0055092)3.74290680
114organic acid catabolic process (GO:0016054)3.73362602
115carboxylic acid catabolic process (GO:0046395)3.73362602
116protein-lipid complex assembly (GO:0065005)3.73348683
117regulation of bile acid biosynthetic process (GO:0070857)3.71226276
118* positive regulation of coagulation (GO:0050820)3.69626401
119* protein activation cascade (GO:0072376)3.66546132
120short-chain fatty acid metabolic process (GO:0046459)3.64903223
121sterol transport (GO:0015918)3.64427647
122cholesterol transport (GO:0030301)3.64427647
123acetyl-CoA metabolic process (GO:0006084)3.63796468
124regulation of cholesterol homeostasis (GO:2000188)3.63632998
125cytolysis (GO:0019835)3.63459361
126* blood coagulation, intrinsic pathway (GO:0007597)3.60108633
127regulation of lipoprotein particle clearance (GO:0010984)3.56877187
128opsonization (GO:0008228)3.55284088
129NAD biosynthetic process (GO:0009435)3.54988962
130negative regulation of lipid transport (GO:0032369)3.41794115
131positive regulation of steroid metabolic process (GO:0045940)3.39857234
132regulation of cholesterol biosynthetic process (GO:0045540)3.29677741
133killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.29583323
134disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.29583323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.43185249
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20921421
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.06419701
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.53593555
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31776264
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.11823952
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85203193
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06839153
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.95475858
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07702218
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0561605
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95841587
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94676956
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60801805
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58933549
16HTT_18923047_ChIP-ChIP_STHdh_Human1.56563748
17CLOCK_20551151_ChIP-Seq_293T_Human1.55214104
18GATA1_22025678_ChIP-Seq_K562_Human1.46064420
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41063515
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28685953
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20592684
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18851425
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17938981
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13558649
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12265723
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.07835589
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04767008
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.01564989
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00858940
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99727714
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92169903
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91348457
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91241028
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86013130
35IRF8_22096565_ChIP-ChIP_GC-B_Human0.85723699
36AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83661791
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82937005
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81471963
39GATA4_25053715_ChIP-Seq_YYC3_Human0.80685735
40TP63_17297297_ChIP-ChIP_HaCaT_Human0.80264467
41POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79685824
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78856301
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77688978
44KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76884118
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76541103
46ZNF263_19887448_ChIP-Seq_K562_Human0.75889302
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75750558
48SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75403733
49RARA_24833708_ChIP-Seq_LIVER_Mouse0.74260668
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71974945
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71047981
52AR_21909140_ChIP-Seq_LNCAP_Human0.70707072
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70385872
54HIF1A_21447827_ChIP-Seq_MCF-7_Human0.69621382
55NFIB_24661679_ChIP-Seq_LUNG_Mouse0.68717768
56SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68560735
57SOX2_20726797_ChIP-Seq_SW620_Human0.67626622
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67216891
59GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66849622
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66401322
61RAC3_21632823_ChIP-Seq_H3396_Human0.66260518
62DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65262725
63ESR2_21235772_ChIP-Seq_MCF-7_Human0.64293700
64RARB_24833708_ChIP-Seq_LIVER_Mouse0.63615648
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63458985
66NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63458985
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63059760
68SOX2_21211035_ChIP-Seq_LN229_Human0.62960899
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61308588
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61075162
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61056180
72RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60973867
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59686695
74SMC4_20622854_ChIP-Seq_HELA_Human0.59369968
75CEBPB_22108803_ChIP-Seq_LS180_Human0.57825149
76NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.56392714
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.55646569
78EGR1_19032775_ChIP-ChIP_M12_Human0.53677938
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.53391664
80CSB_26484114_Chip-Seq_FIBROBLAST_Human0.53302113
81FOXA1_25552417_ChIP-Seq_VCAP_Human0.52984234
82AR_20517297_ChIP-Seq_VCAP_Human0.51879783
83LXR_22292898_ChIP-Seq_THP-1_Human0.51867299
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51777745
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51688149
86SOX11_22085726_ChIP-Seq_ESNs_Mouse0.51627412
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51024659
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.50988249
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49929402
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.49924287
91* MYC_19915707_ChIP-ChIP_AK7_Human0.48933960
92* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48717892
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.48622644
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.48430776
95CBP_21632823_ChIP-Seq_H3396_Human0.48381170
96SMAD1_18555785_Chip-Seq_ESCs_Mouse0.48217063
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.48209949
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.48095107
99STAT1_17558387_ChIP-Seq_HELA_Human0.46638500
100P53_21459846_ChIP-Seq_SAOS-2_Human0.46635601
101PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45789244
102GATA1_19941826_ChIP-Seq_K562_Human0.45054257
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44794117
104SPI1_20517297_ChIP-Seq_HL60_Human0.44228547
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.44061641
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.43897819
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.43714572
108TAF15_26573619_Chip-Seq_HEK293_Human0.43464586
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.43438883
110NFE2_27457419_Chip-Seq_LIVER_Mouse0.43008233
111TP53_16413492_ChIP-PET_HCT116_Human0.42367099
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.42310647
113E2F1_20622854_ChIP-Seq_HELA_Human0.42236682
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42116700
115ESRRB_18555785_Chip-Seq_ESCs_Mouse0.42105056
116TAF2_19829295_ChIP-Seq_ESCs_Human0.42016755
117GATA2_19941826_ChIP-Seq_K562_Human0.41031717
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.41029214
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39879160
120GATA6_25053715_ChIP-Seq_YYC3_Human0.39347913
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39158113
122* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39156223
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.38990954
124* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38557615
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.38447523
126BCAT_22108803_ChIP-Seq_LS180_Human0.38257619
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37689057
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.36910378
129SPI1_26923725_Chip-Seq_HPCs_Mouse0.35125407
130LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34927535
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34523178
132FOXH1_21741376_ChIP-Seq_EPCs_Human0.33706175
133ERG_20517297_ChIP-Seq_VCAP_Human0.33684666
134NCOR_22424771_ChIP-Seq_293T_Human0.33632165
135CDX2_22108803_ChIP-Seq_LS180_Human0.33270686
136SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32210661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.32402621
2MP0005360_urolithiasis7.51670629
3MP0005085_abnormal_gallbladder_physiolo6.44387009
4MP0005365_abnormal_bile_salt6.20006752
5MP0008875_abnormal_xenobiotic_pharmacok5.09003449
6MP0003806_abnormal_nucleotide_metabolis4.25407559
7MP0003252_abnormal_bile_duct3.88932038
8MP0010329_abnormal_lipoprotein_level3.63622506
9MP0009840_abnormal_foam_cell3.37729579
10MP0005083_abnormal_biliary_tract3.13676120
11MP0003195_calcinosis2.80855331
12MP0005332_abnormal_amino_acid2.74048224
13MP0001666_abnormal_nutrient_absorption2.59486441
14MP0003191_abnormal_cellular_cholesterol2.40063092
15MP0003122_maternal_imprinting2.21473189
16MP0000609_abnormal_liver_physiology2.18094135
17MP0004019_abnormal_vitamin_homeostasis2.14267155
18MP0002118_abnormal_lipid_homeostasis2.10885248
19MP0002138_abnormal_hepatobiliary_system1.96522004
20MP0003868_abnormal_feces_composition1.92329399
21MP0005319_abnormal_enzyme/_coenzyme1.82072613
22MP0001764_abnormal_homeostasis1.67928411
23MP0009697_abnormal_copulation1.64728321
24MP0005584_abnormal_enzyme/coenzyme_acti1.56730528
25MP0000566_synostosis1.53382361
26MP0003011_delayed_dark_adaptation1.46718031
27MP0005451_abnormal_body_composition1.44948016
28MP0001915_intracranial_hemorrhage1.44508872
29MP0003656_abnormal_erythrocyte_physiolo1.30995271
30MP0003186_abnormal_redox_activity1.26503810
31MP0009643_abnormal_urine_homeostasis1.21658996
32MP0005058_abnormal_lysosome_morphology1.19923577
33MP0000598_abnormal_liver_morphology1.18818941
34MP0002089_abnormal_postnatal_growth/wei1.16611079
35MP0003705_abnormal_hypodermis_morpholog1.14186610
36MP0005647_abnormal_sex_gland1.13453229
37MP0000604_amyloidosis1.11117918
38MP0009764_decreased_sensitivity_to1.05847865
39MP0002254_reproductive_system_inflammat1.04610092
40MP0009763_increased_sensitivity_to1.03068903
41MP0010368_abnormal_lymphatic_system0.98442108
42MP0003123_paternal_imprinting0.93955057
43MP0005636_abnormal_mineral_homeostasis0.92733563
44MP0003172_abnormal_lysosome_physiology0.91335649
45MP0008469_abnormal_protein_level0.89103752
46MP0009642_abnormal_blood_homeostasis0.87394661
47MP0005408_hypopigmentation0.86519992
48MP0006036_abnormal_mitochondrial_physio0.81553978
49MP0005376_homeostasis/metabolism_phenot0.80163220
50MP0009765_abnormal_xenobiotic_induced0.78456475
51MP0005084_abnormal_gallbladder_morpholo0.78434968
52MP0002078_abnormal_glucose_homeostasis0.77984853
53MP0005670_abnormal_white_adipose0.77102813
54MP0003879_abnormal_hair_cell0.76338418
55MP0002876_abnormal_thyroid_physiology0.76222143
56MP0005220_abnormal_exocrine_pancreas0.73045211
57MP0002971_abnormal_brown_adipose0.71564554
58MP0005334_abnormal_fat_pad0.68916264
59MP0009053_abnormal_anal_canal0.68551827
60MP0001661_extended_life_span0.68108798
61MP0003690_abnormal_glial_cell0.68098088
62MP0004130_abnormal_muscle_cell0.67835132
63MP0004272_abnormal_basement_membrane0.66543285
64MP0002282_abnormal_trachea_morphology0.66359571
65MP0005535_abnormal_body_temperature0.65161378
66MP0005266_abnormal_metabolism0.63679419
67MP0003329_amyloid_beta_deposits0.63408263
68MP0000639_abnormal_adrenal_gland0.62512963
69MP0005409_darkened_coat_color0.61991136
70MP0001756_abnormal_urination0.57741051
71MP0005464_abnormal_platelet_physiology0.56712589
72MP0006035_abnormal_mitochondrial_morpho0.56531226
73MP0005448_abnormal_energy_balance0.55808681
74MP0005167_abnormal_blood-brain_barrier0.53565808
75MP0005023_abnormal_wound_healing0.50106999
76MP0002249_abnormal_larynx_morphology0.49955421
77MP0005395_other_phenotype0.49377856
78MP0009780_abnormal_chondrocyte_physiolo0.48143527
79MP0003718_maternal_effect0.47707406
80MP0002822_catalepsy0.47598708
81MP0003638_abnormal_response/metabolism_0.45793886
82MP0005187_abnormal_penis_morphology0.45703580
83MP0002928_abnormal_bile_duct0.44701515
84MP0003567_abnormal_fetal_cardiomyocyte0.44602762
85MP0008873_increased_physiological_sensi0.44582203
86MP0008874_decreased_physiological_sensi0.44170159
87MP0005257_abnormal_intraocular_pressure0.44050243
88MP0002136_abnormal_kidney_physiology0.43949861
89MP0003436_decreased_susceptibility_to0.42308064
90MP0004782_abnormal_surfactant_physiolog0.41936928
91MP0003878_abnormal_ear_physiology0.41379221
92MP0005377_hearing/vestibular/ear_phenot0.41379221
93MP0003724_increased_susceptibility_to0.41005231
94MP0003953_abnormal_hormone_level0.40669094
95MP0003075_altered_response_to0.40638911
96MP0003632_abnormal_nervous_system0.40428576
97MP0002909_abnormal_adrenal_gland0.39951882
98MP0005248_abnormal_Harderian_gland0.39789488
99MP0004264_abnormal_extraembryonic_tissu0.39162070
100MP0002837_dystrophic_cardiac_calcinosis0.38873683
101MP0000920_abnormal_myelination0.37959475
102MP0009672_abnormal_birth_weight0.37426898
103MP0005166_decreased_susceptibility_to0.37090402
104MP0004381_abnormal_hair_follicle0.36704449
105MP0006054_spinal_hemorrhage0.36670648
106MP0008872_abnormal_physiological_respon0.36345438
107MP0005666_abnormal_adipose_tissue0.36295959
108MP0004883_abnormal_blood_vessel0.34229846
109MP0000579_abnormal_nail_morphology0.33923039
110MP0003183_abnormal_peptide_metabolism0.33890596
111MP0001243_abnormal_dermal_layer0.33018244
112MP0009115_abnormal_fat_cell0.32811804
113MP0000249_abnormal_blood_vessel0.32802511
114MP0002796_impaired_skin_barrier0.32732137
115MP0000003_abnormal_adipose_tissue0.32141535
116MP0001324_abnormal_eye_pigmentation0.31615883
117MP0006082_CNS_inflammation0.30961518
118MP0001853_heart_inflammation0.30663508
119MP0003121_genomic_imprinting0.30526896
120MP0003566_abnormal_cell_adhesion0.30515064
121MP0009384_cardiac_valve_regurgitation0.30416554
122MP0002168_other_aberrant_phenotype0.30227950
123MP0002970_abnormal_white_adipose0.30206189
124MP0000230_abnormal_systemic_arterial0.29804729
125MP0002933_joint_inflammation0.29119068
126MP0001881_abnormal_mammary_gland0.28467385
127MP0002128_abnormal_blood_circulation0.28171392
128MP0001845_abnormal_inflammatory_respons0.27954397
129MP0000858_altered_metastatic_potential0.27743964
130MP0005410_abnormal_fertilization0.26991461
131MP0005164_abnormal_response_to0.26503090
132MP0003943_abnormal_hepatobiliary_system0.26496819
133MP0002132_abnormal_respiratory_system0.25839484
134MP0002090_abnormal_vision0.23595201
135MP0002060_abnormal_skin_morphology0.23343175

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.44277760
2Intrahepatic cholestasis (HP:0001406)7.36211099
3* Deep venous thrombosis (HP:0002625)7.01116575
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.72748483
5Hypobetalipoproteinemia (HP:0003563)6.58390019
6Xanthomatosis (HP:0000991)6.37908244
7* Prolonged partial thromboplastin time (HP:0003645)6.18138741
8Hyperlipoproteinemia (HP:0010980)5.66042069
9Complement deficiency (HP:0004431)5.42483327
10Hypolipoproteinemia (HP:0010981)4.95083496
11Hyperammonemia (HP:0001987)4.64098214
12Abnormality of the common coagulation pathway (HP:0010990)4.61852314
13Epidermoid cyst (HP:0200040)4.54904690
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.52348092
15Hyperglycinemia (HP:0002154)4.44669793
16Hypoalphalipoproteinemia (HP:0003233)4.33219287
17Abnormality of methionine metabolism (HP:0010901)4.33015320
18Ketosis (HP:0001946)4.26573420
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.26427805
20* Joint hemorrhage (HP:0005261)4.20639224
21Fat malabsorption (HP:0002630)4.16062728
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14663739
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14618317
24Abnormality of complement system (HP:0005339)3.95900209
25Abnormality of glycine metabolism (HP:0010895)3.92274512
26Abnormality of serine family amino acid metabolism (HP:0010894)3.92274512
27Hypoglycemic coma (HP:0001325)3.91996567
28Hyperglycinuria (HP:0003108)3.91445958
29Abnormality of pyrimidine metabolism (HP:0004353)3.88178885
30Abnormality of the intrinsic pathway (HP:0010989)3.85936769
31Conjugated hyperbilirubinemia (HP:0002908)3.75619480
32Hypercholesterolemia (HP:0003124)3.70840939
33Hyperbilirubinemia (HP:0002904)3.40575870
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37191862
35Abnormality of fatty-acid metabolism (HP:0004359)3.33539650
36Spontaneous abortion (HP:0005268)3.19416559
37Purpura (HP:0000979)3.15945296
38Steatorrhea (HP:0002570)3.11127326
39Delayed CNS myelination (HP:0002188)3.08996607
40Abnormality of serum amino acid levels (HP:0003112)3.08955071
41Hypochromic microcytic anemia (HP:0004840)3.08138729
42Abnormality of nucleobase metabolism (HP:0010932)3.05974389
43Hepatocellular carcinoma (HP:0001402)3.03396426
44Ketoacidosis (HP:0001993)3.00575714
45Myocardial infarction (HP:0001658)2.96459497
46Skin nodule (HP:0200036)2.80332368
47Metabolic acidosis (HP:0001942)2.76786321
48Systemic lupus erythematosus (HP:0002725)2.73978412
49Acanthocytosis (HP:0001927)2.72653854
50* Menorrhagia (HP:0000132)2.66477978
51Abnormality of purine metabolism (HP:0004352)2.64872141
52Osteomalacia (HP:0002749)2.61654350
53Lethargy (HP:0001254)2.60946713
54Vascular calcification (HP:0004934)2.59617126
55Dicarboxylic aciduria (HP:0003215)2.57290303
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57290303
57Hypoglycemic seizures (HP:0002173)2.55023714
58Glomerulonephritis (HP:0000099)2.55001415
59Abnormal gallbladder morphology (HP:0012437)2.53401359
60Abnormal gallbladder physiology (HP:0012438)2.47881658
61Cholecystitis (HP:0001082)2.47881658
62Cholelithiasis (HP:0001081)2.47271637
63Spastic diplegia (HP:0001264)2.45854157
64Cerebral edema (HP:0002181)2.43084216
65Mitral stenosis (HP:0001718)2.42123209
66Amyloidosis (HP:0011034)2.40838149
67Gout (HP:0001997)2.39398212
68Recurrent gram-negative bacterial infections (HP:0005420)2.36617916
69Irritability (HP:0000737)2.35729802
70Neonatal onset (HP:0003623)2.34147121
71Arthropathy (HP:0003040)2.30662001
72Cardiovascular calcification (HP:0011915)2.30034264
73Malnutrition (HP:0004395)2.26629155
74Esophageal varix (HP:0002040)2.26308399
75Abnormality of carpal bone ossification (HP:0006257)2.19027050
76Abnormal tarsal ossification (HP:0008369)2.17623398
77Abnormality of the Achilles tendon (HP:0005109)2.15070678
78Pancreatitis (HP:0001733)2.15056776
79Poikilocytosis (HP:0004447)2.14721880
80Brushfield spots (HP:0001088)2.14094287
81Late onset (HP:0003584)2.14008831
82Enlarged kidneys (HP:0000105)2.12996253
83Sensorimotor neuropathy (HP:0007141)2.12320244
84Vomiting (HP:0002013)2.06457309
85Hyperinsulinemic hypoglycemia (HP:0000825)2.05846055
86Abnormality of the gallbladder (HP:0005264)2.04956955
87Increased serum pyruvate (HP:0003542)2.03843703
88Hemorrhage of the eye (HP:0011885)2.03293832
89Opisthotonus (HP:0002179)2.02285877
90Generalized aminoaciduria (HP:0002909)2.01490025
91Abnormality of iron homeostasis (HP:0011031)1.94599947
92Bifid scrotum (HP:0000048)1.94271994
93Rickets (HP:0002748)1.94105188
94Reduced antithrombin III activity (HP:0001976)1.93001404
95Abnormality of transition element cation homeostasis (HP:0011030)1.91663193
96Abnormal cartilage morphology (HP:0002763)1.87860338
97Renal cortical cysts (HP:0000803)1.86586959
98Hypophosphatemic rickets (HP:0004912)1.86534061
99* Thrombophlebitis (HP:0004418)1.85640449
100Facial shape deformation (HP:0011334)1.85508385
101Potter facies (HP:0002009)1.85508385
102Joint swelling (HP:0001386)1.83610326
103Abnormality of proline metabolism (HP:0010907)1.83167093
104Hydroxyprolinuria (HP:0003080)1.83167093
105Elevated hepatic transaminases (HP:0002910)1.82180592
106Abnormality of glycolysis (HP:0004366)1.81553339
107Alkalosis (HP:0001948)1.81101966
108Abnormal enzyme/coenzyme activity (HP:0012379)1.80724486
109* Gingival bleeding (HP:0000225)1.80524987
110Nephritis (HP:0000123)1.80400188
111Gangrene (HP:0100758)1.78943664
112Status epilepticus (HP:0002133)1.78431601
113Hyperglycemia (HP:0003074)1.75615229
114Abnormal delivery (HP:0001787)1.75109369
115Reticulocytosis (HP:0001923)1.74513540
116Abnormality of vitamin metabolism (HP:0100508)1.74256332
117Fair hair (HP:0002286)1.74038785
118Vaginal fistula (HP:0004320)1.72108115
119Increased serum ferritin (HP:0003281)1.71224451
120Pancreatic islet-cell hyperplasia (HP:0004510)1.71107295
121* Pulmonary embolism (HP:0002204)1.66831241
122Asymmetry of the thorax (HP:0001555)1.65946947
123Flat acetabular roof (HP:0003180)1.65392704
124Broad alveolar ridges (HP:0000187)1.64367494
125Elevated alkaline phosphatase (HP:0003155)1.63955633
126Hyperphosphaturia (HP:0003109)1.63617497
127Glycosuria (HP:0003076)1.59222233
128Abnormality of urine glucose concentration (HP:0011016)1.59222233
129Abnormal hand bone ossification (HP:0010660)1.58004908
130Retinal atrophy (HP:0001105)1.57878756
131Abnormality of alkaline phosphatase activity (HP:0004379)1.56676946
132Abnormality of the lumbar spine (HP:0100712)1.55906904
133Abnormal ossification of hand bones (HP:0005921)1.55430000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15763742
2FGFR44.64295580
3SIK14.60190898
4ERN14.33950905
5TAOK33.17442085
6INSRR3.03868730
7WNK42.98991792
8ERBB42.93316735
9CDK122.56232312
10MAP2K42.33568216
11PKN22.26627759
12MST1R2.14311944
13FLT31.96336339
14MAPK111.91835519
15TYRO31.90474539
16PIK3CG1.87414271
17PDGFRA1.85564621
18FGFR11.81781141
19TRIB31.74524995
20TYK21.73379186
21LATS11.67084972
22DAPK21.63142466
23AKT31.60944125
24ABL21.48604321
25PTK61.47281700
26NEK91.45209118
27FGFR21.37520452
28FRK1.35696805
29KDR1.34255274
30WNK11.23771884
31JAK21.23195241
32NTRK31.17832683
33MAP3K71.17303701
34SIK21.16925977
35MAP3K21.16433106
36PINK11.13035193
37PRKAA21.12875700
38EIF2AK11.12060712
39PDK21.11735976
40GRK61.07919888
41MAP2K31.07456629
42ERBB21.03316100
43TBK11.02743048
44JAK11.02411957
45EEF2K1.00876411
46MAPK40.99340896
47MAP3K100.98547770
48MAP3K140.95803143
49PRKCZ0.90989230
50DDR20.88386378
51MAP3K30.87780754
52MET0.87434408
53STK38L0.85212529
54EPHB10.84006750
55MAPKAPK30.82863832
56CDK60.81706613
57EPHA30.81259574
58MAP3K110.80462649
59MAPK120.80373917
60MAPK150.78848448
61TIE10.77939302
62PRKACG0.77393128
63CSNK1E0.75861695
64CDK70.74610109
65SGK10.74072482
66CAMK2G0.71658443
67DYRK1B0.71330403
68CAMK1D0.70746799
69CSK0.69530230
70GSK3A0.67443783
71PRKAA10.66096798
72MAP2K60.65597036
73RPS6KB10.63101206
74SGK30.62947806
75RIPK10.61769845
76IRAK30.59755758
77EPHA20.58964909
78TGFBR20.58423746
79CSNK1D0.58085914
80MAPK70.57453116
81FGFR30.56997509
82FGR0.56779408
83CSF1R0.56519134
84PTK20.56165859
85SMG10.55030129
86KSR20.54822721
87IKBKE0.52838006
88CDC42BPA0.51564620
89PRKCQ0.50631518
90PDPK10.48770779
91PRKG10.47850277
92CSNK1G10.47510287
93TAOK20.47282920
94SGK20.46555627
95MAP3K50.46116167
96GRK10.45988277
97NLK0.45633223
98EPHA40.45465704
99CSNK2A20.45103786
100MAP2K10.44734494
101IGF1R0.43921440
102BRSK10.43118326
103NEK10.43052977
104CDK40.42585290
105SRC0.42370589
106RET0.42082132
107PRKCG0.42002095
108RPS6KA30.40962068
109CSNK2A10.40448285
110MAP3K130.40074212
111MAP3K60.38759797
112ICK0.38641678
113BCR0.38231403
114PKN10.37986368
115BRSK20.36936253
116PBK0.36058097
117MTOR0.35876394
118MATK0.35249473
119PRKACA0.34607526
120EGFR0.33294953
121SGK2230.32874244
122SGK4940.32874244
123CAMK40.31771068
124PRKCB0.31460498
125PDK10.30261053
126PRKACB0.29787291
127MAP3K10.29028232
128CSNK1G20.27341553
129CDK90.26657921
130CDK80.26545032
131PRKCA0.25608438
132LATS20.25240790
133BRD40.24727786
134NEK20.24517758
135CSNK1G30.23506249
136IRAK10.22512452
137MAP2K20.22308668
138CAMK1G0.21278570
139PIK3CA0.21203146
140PAK30.20704063
141ABL10.20547799
142IRAK20.19074288
143MAPK30.18773527

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50836828
2Nitrogen metabolism_Homo sapiens_hsa009103.66829523
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39084598
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35553726
5Arginine biosynthesis_Homo sapiens_hsa002203.09162431
6* Complement and coagulation cascades_Homo sapiens_hsa046102.76370539
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71652058
8Tryptophan metabolism_Homo sapiens_hsa003802.66850392
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63191135
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55421195
11Fatty acid degradation_Homo sapiens_hsa000712.48467514
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37039690
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23892794
14Butanoate metabolism_Homo sapiens_hsa006502.14561506
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13345848
16Peroxisome_Homo sapiens_hsa041462.06352282
17Chemical carcinogenesis_Homo sapiens_hsa052041.94841837
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92273861
19Propanoate metabolism_Homo sapiens_hsa006401.91643247
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.91376420
21Histidine metabolism_Homo sapiens_hsa003401.90499541
22PPAR signaling pathway_Homo sapiens_hsa033201.86936903
23Fatty acid metabolism_Homo sapiens_hsa012121.81325871
24Staphylococcus aureus infection_Homo sapiens_hsa051501.80299134
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76362128
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74985701
27beta-Alanine metabolism_Homo sapiens_hsa004101.70925846
28Retinol metabolism_Homo sapiens_hsa008301.69793914
29Caffeine metabolism_Homo sapiens_hsa002321.68789772
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65316321
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61990699
32Selenocompound metabolism_Homo sapiens_hsa004501.58477975
33Phenylalanine metabolism_Homo sapiens_hsa003601.55966968
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50925138
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50455416
36Bile secretion_Homo sapiens_hsa049761.48274798
37Tyrosine metabolism_Homo sapiens_hsa003501.43779642
38Pyruvate metabolism_Homo sapiens_hsa006201.35789805
39Fatty acid elongation_Homo sapiens_hsa000621.34134880
40Sulfur metabolism_Homo sapiens_hsa009201.33387200
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32183630
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27791940
43Steroid biosynthesis_Homo sapiens_hsa001001.22466169
44Biosynthesis of amino acids_Homo sapiens_hsa012301.21190657
45ABC transporters_Homo sapiens_hsa020101.20493172
46Folate biosynthesis_Homo sapiens_hsa007901.20405817
47Fat digestion and absorption_Homo sapiens_hsa049751.19410625
48Carbon metabolism_Homo sapiens_hsa012001.12995776
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.02117719
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02003569
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00673969
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.98388865
53Vitamin B6 metabolism_Homo sapiens_hsa007500.97883814
54Arginine and proline metabolism_Homo sapiens_hsa003300.96690353
55Sulfur relay system_Homo sapiens_hsa041220.93743476
56Vitamin digestion and absorption_Homo sapiens_hsa049770.88322784
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87440266
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82176691
59Lysine degradation_Homo sapiens_hsa003100.81209112
60One carbon pool by folate_Homo sapiens_hsa006700.78021952
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70540069
62Glycerolipid metabolism_Homo sapiens_hsa005610.67599333
63Other glycan degradation_Homo sapiens_hsa005110.66357174
64Glutathione metabolism_Homo sapiens_hsa004800.65105066
65Pentose phosphate pathway_Homo sapiens_hsa000300.59030580
66Fatty acid biosynthesis_Homo sapiens_hsa000610.54468261
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45826086
68Metabolic pathways_Homo sapiens_hsa011000.45768740
69Pertussis_Homo sapiens_hsa051330.45141310
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41730382
71Prion diseases_Homo sapiens_hsa050200.35035062
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26303549
73Galactose metabolism_Homo sapiens_hsa000520.25887706
74Fructose and mannose metabolism_Homo sapiens_hsa000510.24430994
75Insulin resistance_Homo sapiens_hsa049310.22903219
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22052484
77Linoleic acid metabolism_Homo sapiens_hsa005910.21979343
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.21439251
79N-Glycan biosynthesis_Homo sapiens_hsa005100.18920623
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.15794779
81Glucagon signaling pathway_Homo sapiens_hsa049220.09663452
82Mineral absorption_Homo sapiens_hsa049780.08029678
83AMPK signaling pathway_Homo sapiens_hsa041520.01812222
84Sphingolipid metabolism_Homo sapiens_hsa006000.00608928
85Bladder cancer_Homo sapiens_hsa05219-0.2452470
86Amoebiasis_Homo sapiens_hsa05146-0.2450822
87Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2437263
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2383659
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2329127
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2053329
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1989151
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1901446
93Renin-angiotensin system_Homo sapiens_hsa04614-0.1897473
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1878510
95Hepatitis C_Homo sapiens_hsa05160-0.1755909
96Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1671173
97Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1629528
98Circadian rhythm_Homo sapiens_hsa04710-0.1625100
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1616428
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1592047
101Regulation of autophagy_Homo sapiens_hsa04140-0.1405050
102African trypanosomiasis_Homo sapiens_hsa05143-0.1352708
103Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1204752
104ECM-receptor interaction_Homo sapiens_hsa04512-0.1067503
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1009420
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0849411
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0707019
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0654823
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0486204

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