F2R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)5.15905630
2chondrocyte proliferation (GO:0035988)5.06182237
3cell adhesion mediated by integrin (GO:0033627)4.71215274
4mesodermal cell differentiation (GO:0048333)4.61845266
5vascular endothelial growth factor signaling pathway (GO:0038084)4.13533115
6axon extension involved in axon guidance (GO:0048846)4.09165367
7neuron projection extension involved in neuron projection guidance (GO:1902284)4.09165367
8hippo signaling (GO:0035329)4.06590475
9endodermal cell differentiation (GO:0035987)3.99921191
10cell migration involved in sprouting angiogenesis (GO:0002042)3.86984059
11basement membrane organization (GO:0071711)3.86982304
12collagen fibril organization (GO:0030199)3.85782995
13positive regulation of endothelial cell differentiation (GO:0045603)3.77401588
14lymphangiogenesis (GO:0001946)3.77185353
15lymph vessel development (GO:0001945)3.75057546
16sequestering of extracellular ligand from receptor (GO:0035581)3.66062708
17* thrombin receptor signaling pathway (GO:0070493)3.56302609
18endocardial cushion development (GO:0003197)3.55754786
19extracellular fibril organization (GO:0043206)3.53808801
20epithelial cell-cell adhesion (GO:0090136)3.49110785
21ganglion development (GO:0061548)3.48717863
22negative regulation of fatty acid transport (GO:2000192)3.46477540
23renal filtration (GO:0097205)3.45824763
24definitive hemopoiesis (GO:0060216)3.45085305
25glomerular basement membrane development (GO:0032836)3.41930204
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.40716126
27positive regulation of epithelial to mesenchymal transition (GO:0010718)3.39979931
28positive regulation of endothelial cell apoptotic process (GO:2000353)3.35661154
29negative chemotaxis (GO:0050919)3.34692119
30retina vasculature morphogenesis in camera-type eye (GO:0061299)3.34253148
31germ cell migration (GO:0008354)3.32609743
32blood vessel endothelial cell migration (GO:0043534)3.32348155
33substrate-dependent cell migration (GO:0006929)3.29029945
34cell migration involved in heart development (GO:0060973)3.28114209
35cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.26692864
36regulation of endothelial cell differentiation (GO:0045601)3.25565213
37type B pancreatic cell proliferation (GO:0044342)3.24277256
38positive regulation of blood vessel endothelial cell migration (GO:0043536)3.22729395
39negative regulation of axon extension involved in axon guidance (GO:0048843)3.22286139
40dermatan sulfate biosynthetic process (GO:0030208)3.21694033
41neural crest cell development (GO:0014032)3.21473493
42substrate adhesion-dependent cell spreading (GO:0034446)3.20502388
43muscle cell migration (GO:0014812)3.19707891
44paraxial mesoderm development (GO:0048339)3.18921512
45Notch signaling involved in heart development (GO:0061314)3.17489452
46regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.15779821
47endothelial tube morphogenesis (GO:0061154)3.13859656
48morphogenesis of an endothelium (GO:0003159)3.13859656
49sprouting angiogenesis (GO:0002040)3.07626102
50skin morphogenesis (GO:0043589)3.07060935
51extracellular matrix assembly (GO:0085029)3.05507556
52regulation of integrin-mediated signaling pathway (GO:2001044)3.05469145
53glomerular filtration (GO:0003094)3.05446995
54wound healing, spreading of epidermal cells (GO:0035313)3.05004750
55angiogenesis involved in wound healing (GO:0060055)3.04529313
56negative regulation of axon guidance (GO:1902668)3.00850509
57dermatan sulfate metabolic process (GO:0030205)3.00005722
58heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.99694097
59bone trabecula formation (GO:0060346)2.99208947
60regulation of SMAD protein import into nucleus (GO:0060390)2.98896890
61cellular response to vitamin (GO:0071295)2.97396895
62protein heterotrimerization (GO:0070208)2.97096920
63negative regulation of chondrocyte differentiation (GO:0032331)2.95746030
64plasma membrane repair (GO:0001778)2.94205613
65endothelial cell morphogenesis (GO:0001886)2.93308946
66* positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.92972602
67positive regulation of chondrocyte differentiation (GO:0032332)2.91619501
68regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91510628
69COPI coating of Golgi vesicle (GO:0048205)2.90900359
70Golgi transport vesicle coating (GO:0048200)2.90900359
71regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.89346010
72blood vessel maturation (GO:0001955)2.89278457
73fibril organization (GO:0097435)2.87717618
74atrioventricular valve morphogenesis (GO:0003181)2.85451905
75negative regulation of smooth muscle cell migration (GO:0014912)2.84651118
76negative regulation of cartilage development (GO:0061037)2.83645291
77mesenchymal cell development (GO:0014031)2.83579780
78regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.80802488
79vasculature development (GO:0001944)2.80001601
80adherens junction assembly (GO:0034333)2.78698738
81cell-substrate junction assembly (GO:0007044)2.77823090
82collagen catabolic process (GO:0030574)2.77641330
83negative regulation of protein localization to cell surface (GO:2000009)2.76997267
84polarized epithelial cell differentiation (GO:0030859)2.76927451
85venous blood vessel morphogenesis (GO:0048845)2.75592182
86endothelial cell proliferation (GO:0001935)2.74338580
87tonic smooth muscle contraction (GO:0014820)2.73713154
88vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73553877
89endothelial cell differentiation (GO:0045446)2.73144999
90regulation of axon extension involved in axon guidance (GO:0048841)2.72795600
91mesenchymal-epithelial cell signaling (GO:0060638)2.72482230
92smooth muscle tissue development (GO:0048745)2.71802210
93protein localization to cell surface (GO:0034394)2.70476835
94regulation of tight junction assembly (GO:2000810)2.68144469
95positive regulation of macrophage activation (GO:0043032)2.66952634
96stress fiber assembly (GO:0043149)2.66337013
97regulation of cartilage development (GO:0061035)2.65898626
98positive regulation of fibroblast migration (GO:0010763)2.65254046
99cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.65195284
100cell-substrate adhesion (GO:0031589)2.65017143
101regulation of axon guidance (GO:1902667)2.64747902
102positive regulation of epithelial cell migration (GO:0010634)2.64482530
103platelet degranulation (GO:0002576)2.63788016
104positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.63518300
105multicellular organismal macromolecule metabolic process (GO:0044259)2.63434611
106negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.62872991
107regulation of heart morphogenesis (GO:2000826)2.62132415
108negative regulation of nitric-oxide synthase activity (GO:0051001)2.59789976
109extracellular matrix organization (GO:0030198)2.58924663
110extracellular structure organization (GO:0043062)2.57809692
111wound healing, spreading of cells (GO:0044319)2.57512556
112patterning of blood vessels (GO:0001569)2.56059281
113regulation of chondrocyte differentiation (GO:0032330)2.55169897
114positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.55162671
115metanephric mesenchyme development (GO:0072075)2.54350221
116epithelial to mesenchymal transition (GO:0001837)2.54325801
117positive regulation of SMAD protein import into nucleus (GO:0060391)2.52250682
118response to fluid shear stress (GO:0034405)2.51338161
119positive regulation of cartilage development (GO:0061036)2.50487651
120positive regulation of BMP signaling pathway (GO:0030513)2.50351917
121insulin-like growth factor receptor signaling pathway (GO:0048009)2.50159914
122atrial septum morphogenesis (GO:0060413)2.49089490
123vasculogenesis (GO:0001570)2.48174342
124notochord development (GO:0030903)2.47586080
125endothelial cell migration (GO:0043542)2.46906346
126positive regulation of stem cell differentiation (GO:2000738)2.45200800
127glomerular visceral epithelial cell development (GO:0072015)2.44735914
128positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.44656562
129cellular response to vitamin D (GO:0071305)2.44197744
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.44146458
131craniofacial suture morphogenesis (GO:0097094)2.43398752
132kidney mesenchyme development (GO:0072074)2.43271896
133cell proliferation involved in metanephros development (GO:0072203)2.42852622
134extracellular matrix disassembly (GO:0022617)2.42839245
135blood vessel morphogenesis (GO:0048514)2.42018112
136positive regulation of osteoblast proliferation (GO:0033690)2.41947817
137coronary vasculature morphogenesis (GO:0060977)2.41541279
138G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.41419611
139collagen metabolic process (GO:0032963)2.41347125
140artery development (GO:0060840)2.41239876
141cell-matrix adhesion (GO:0007160)2.41176318
142mesenchyme morphogenesis (GO:0072132)2.41116994
143pathway-restricted SMAD protein phosphorylation (GO:0060389)2.40610133
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40195644
145positive regulation of endothelial cell migration (GO:0010595)2.39721939
146endocardial cushion morphogenesis (GO:0003203)2.39529222
147regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.38540603
148lung vasculature development (GO:0060426)2.37966720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.26725698
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.53550392
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.15972657
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.97650797
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.94830155
6CLOCK_20551151_ChIP-Seq_293T_Human3.34390710
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.25531397
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06524922
9E2F7_22180533_ChIP-Seq_HELA_Human3.06172587
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.81178987
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77761808
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.56135675
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.47537848
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.46030658
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.32572216
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32238311
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.27581254
18BRD4_25478319_ChIP-Seq_HGPS_Human2.21004609
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.18256964
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.15973952
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14355844
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05332634
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.03124936
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99129492
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99129492
26* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96047097
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.95383654
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94962256
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94902981
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93247332
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93096761
32AR_21909140_ChIP-Seq_LNCAP_Human1.93028362
33CJUN_26792858_Chip-Seq_BT549_Human1.92214585
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89219678
35* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87488319
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83607297
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83347625
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82251010
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80602879
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79466914
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.76513259
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.70899634
43* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.70553407
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.70281756
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70061432
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68520551
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67902430
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.66687588
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65049867
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65049867
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64231328
52* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63799692
53GBX2_23144817_ChIP-Seq_PC3_Human1.61689181
54* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61429729
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60568973
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.59326708
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52749389
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.51301601
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50582391
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48602399
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.47858505
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.45391552
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44851572
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44669631
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41294867
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.37980172
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37526886
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36334568
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.36293786
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.36152157
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34238363
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33952568
73SA1_22415368_ChIP-Seq_MEFs_Mouse1.33951636
74MYC_22102868_ChIP-Seq_BL_Human1.33656428
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32231618
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31536125
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.28162044
78P300_19829295_ChIP-Seq_ESCs_Human1.27931169
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27871881
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27487443
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27249007
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26595739
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.26319670
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26114195
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25784633
86TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25710781
87SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.25527197
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25071285
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24120706
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23598208
91* TCF7_22412390_ChIP-Seq_EML_Mouse1.23432450
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22684419
93ATF3_27146783_Chip-Seq_COLON_Human1.22441873
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21321878
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.20496673
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19850626
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19613914
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19098244
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.18552051
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16944446
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16881669
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16729140
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14913623
104SMAD4_21799915_ChIP-Seq_A2780_Human1.14211022
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14190294
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13715646
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13284213
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13096806
109SCL_19346495_ChIP-Seq_HPC-7_Human1.10478969
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09507041
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.09339336
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.09339336
113* SOX2_20726797_ChIP-Seq_SW620_Human1.09191182
114* KDM2B_26808549_Chip-Seq_DND41_Human1.08730462
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08650865
116MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08530992
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.07411460
118SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06858848
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06341995
120JUN_21703547_ChIP-Seq_K562_Human1.05674808
121ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05594057
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05413746
123CBX2_27304074_Chip-Seq_ESCs_Mouse1.03667915
124E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03134710
125ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02145707
126RNF2_27304074_Chip-Seq_NSC_Mouse1.01984582
127TP53_16413492_ChIP-PET_HCT116_Human1.01886280
128RING1B_27294783_Chip-Seq_ESCs_Mouse1.01448717
129RNF2_27304074_Chip-Seq_ESCs_Mouse1.01406905
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00966658
131* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00503287
132ESR1_20079471_ChIP-ChIP_T-47D_Human1.00453591
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00391127
134NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00391127
135TP53_20018659_ChIP-ChIP_R1E_Mouse1.00385850
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.00324200
137* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99923457
138TAF15_26573619_Chip-Seq_HEK293_Human0.99700154
139* TP53_18474530_ChIP-ChIP_U2OS_Human0.99661961
140TP53_23651856_ChIP-Seq_MEFs_Mouse0.99080421
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99008854
142NCOR1_26117541_ChIP-Seq_K562_Human0.98870012
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98424760
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.96361296
145ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96310961
146TP53_22127205_ChIP-Seq_IMR90_Human0.96120901
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95511659
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94746140
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90650102
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88964080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.70484124
2MP0010368_abnormal_lymphatic_system3.76612609
3MP0003705_abnormal_hypodermis_morpholog3.63519279
4MP0003279_aneurysm3.23908049
5MP0004272_abnormal_basement_membrane3.17143896
6MP0005623_abnormal_meninges_morphology3.14322574
7MP0006054_spinal_hemorrhage3.02791083
8MP0005503_abnormal_tendon_morphology3.01006299
9MP0010352_gastrointestinal_tract_polyps2.84030234
10MP0005275_abnormal_skin_tensile2.80541742
11MP0003566_abnormal_cell_adhesion2.57855013
12MP0001879_abnormal_lymphatic_vessel2.54525946
13MP0001958_emphysema2.36626115
14MP0010030_abnormal_orbit_morphology2.32000295
15MP0009053_abnormal_anal_canal2.15850524
16MP0000537_abnormal_urethra_morphology2.11332896
17MP0002877_abnormal_melanocyte_morpholog2.04513973
18MP0009384_cardiac_valve_regurgitation2.00014627
19MP0005023_abnormal_wound_healing1.86727096
20MP0003091_abnormal_cell_migration1.80000259
21MP0003385_abnormal_body_wall1.74592932
22MP0000733_abnormal_muscle_development1.73029429
23MP0005171_absent_coat_pigmentation1.67745976
24MP0000767_abnormal_smooth_muscle1.66523797
25MP0005595_abnormal_vascular_smooth1.66071439
26MP0005508_abnormal_skeleton_morphology1.63814216
27MP0004808_abnormal_hematopoietic_stem1.61560712
28MP0003942_abnormal_urinary_system1.58358454
29MP0009250_abnormal_appendicular_skeleto1.57621140
30MP0003300_gastrointestinal_ulcer1.46546733
31MP0004084_abnormal_cardiac_muscle1.45163313
32MP0000534_abnormal_ureter_morphology1.43125936
33MP0005464_abnormal_platelet_physiology1.40289309
34MP0000013_abnormal_adipose_tissue1.38342961
35MP0003122_maternal_imprinting1.33091846
36MP0003115_abnormal_respiratory_system1.32745467
37MP0002932_abnormal_joint_morphology1.29630714
38* MP0002128_abnormal_blood_circulation1.28006295
39MP0001915_intracranial_hemorrhage1.27563654
40* MP0002925_abnormal_cardiovascular_devel1.27005140
41MP0002282_abnormal_trachea_morphology1.18045422
42MP0005167_abnormal_blood-brain_barrier1.17676223
43MP0001299_abnormal_eye_distance/1.15992046
44MP0003935_abnormal_craniofacial_develop1.15881235
45MP0000516_abnormal_urinary_system1.15868457
46MP0005367_renal/urinary_system_phenotyp1.15868457
47* MP0001614_abnormal_blood_vessel1.14809211
48MP0005076_abnormal_cell_differentiation1.14701250
49MP0003567_abnormal_fetal_cardiomyocyte1.14575008
50MP0002060_abnormal_skin_morphology1.12995066
51MP0008004_abnormal_stomach_pH1.11564676
52MP0000428_abnormal_craniofacial_morphol1.11371378
53MP0003950_abnormal_plasma_membrane1.09115781
54MP0002295_abnormal_pulmonary_circulatio1.08465387
55MP0009697_abnormal_copulation1.07292440
56MP0002896_abnormal_bone_mineralization1.07174514
57MP0008007_abnormal_cellular_replicative1.06312090
58* MP0002086_abnormal_extraembryonic_tissu1.06161434
59MP0000465_gastrointestinal_hemorrhage1.05716985
60MP0006138_congestive_heart_failure1.04193990
61MP0003941_abnormal_skin_development1.02718698
62MP0003828_pulmonary_edema1.02716412
63MP0010630_abnormal_cardiac_muscle1.01744607
64MP0000163_abnormal_cartilage_morphology1.01630137
65MP0004134_abnormal_chest_morphology1.01559209
66MP0002088_abnormal_embryonic_growth/wei1.00675062
67MP0002113_abnormal_skeleton_development1.00245484
68MP0003937_abnormal_limbs/digits/tail_de0.99034868
69MP0004197_abnormal_fetal_growth/weight/0.98881659
70MP0001293_anophthalmia0.98310949
71MP0002396_abnormal_hematopoietic_system0.97328636
72* MP0003984_embryonic_growth_retardation0.97256367
73MP0002177_abnormal_outer_ear0.96541082
74MP0003283_abnormal_digestive_organ0.95694127
75MP0000049_abnormal_middle_ear0.94451274
76MP0000762_abnormal_tongue_morphology0.94258978
77MP0003755_abnormal_palate_morphology0.93594379
78MP0001243_abnormal_dermal_layer0.93090253
79MP0008775_abnormal_heart_ventricle0.92838901
80MP0002127_abnormal_cardiovascular_syste0.91023683
81MP0000266_abnormal_heart_morphology0.90426664
82MP0009780_abnormal_chondrocyte_physiolo0.90084893
83MP0000432_abnormal_head_morphology0.88405438
84MP0000778_abnormal_nervous_system0.88210127
85MP0002115_abnormal_skeleton_extremities0.88045444
86MP0000751_myopathy0.86711833
87MP0001175_abnormal_lung_morphology0.86586635
88MP0005390_skeleton_phenotype0.86351072
89MP0001849_ear_inflammation0.86173305
90MP0001542_abnormal_bone_strength0.85973649
91MP0005409_darkened_coat_color0.84952912
92MP0005084_abnormal_gallbladder_morpholo0.84934575
93MP0002108_abnormal_muscle_morphology0.84506658
94MP0004133_heterotaxia0.84328033
95MP0005257_abnormal_intraocular_pressure0.84000314
96MP0005187_abnormal_penis_morphology0.83570502
97MP0006276_abnormal_autonomic_nervous0.83555887
98MP0002751_abnormal_autonomic_nervous0.83383650
99* MP0001672_abnormal_embryogenesis/_devel0.83123847
100* MP0005380_embryogenesis_phenotype0.83123847
101MP0008789_abnormal_olfactory_epithelium0.83035744
102MP0003123_paternal_imprinting0.82863773
103MP0003119_abnormal_digestive_system0.82582423
104MP0005165_increased_susceptibility_to0.82228488
105MP0002697_abnormal_eye_size0.80991972
106MP0004858_abnormal_nervous_system0.80817938
107MP0001286_abnormal_eye_development0.80621124
108MP0002084_abnormal_developmental_patter0.79423161
109MP0005248_abnormal_Harderian_gland0.79364333
110MP0002089_abnormal_postnatal_growth/wei0.79082548
111MP0009278_abnormal_bone_marrow0.78765142
112MP0002234_abnormal_pharynx_morphology0.78333981
113MP0002233_abnormal_nose_morphology0.77909488
114MP0000858_altered_metastatic_potential0.77018287
115MP0003943_abnormal_hepatobiliary_system0.76275577
116MP0002116_abnormal_craniofacial_bone0.75654448
117MP0003121_genomic_imprinting0.75534018
118* MP0002085_abnormal_embryonic_tissue0.75162055
119MP0001730_embryonic_growth_arrest0.73654165
120MP0002109_abnormal_limb_morphology0.73462162
121* MP0001697_abnormal_embryo_size0.73223016
122MP0002249_abnormal_larynx_morphology0.71558900
123MP0000467_abnormal_esophagus_morphology0.71492508
124* MP0000249_abnormal_blood_vessel0.71003952
125MP0002092_abnormal_eye_morphology0.70405451
126MP0002933_joint_inflammation0.69876419
127MP0005193_abnormal_anterior_eye0.69852827
128* MP0001784_abnormal_fluid_regulation0.69789257
129MP0005197_abnormal_uvea_morphology0.69198635
130MP0002111_abnormal_tail_morphology0.69087033
131MP0001529_abnormal_vocalization0.68921145
132MP0003448_altered_tumor_morphology0.68880896
133MP0010386_abnormal_urinary_bladder0.68377786
134MP0004085_abnormal_heartbeat0.67065823
135MP0000613_abnormal_salivary_gland0.63608309

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.56493775
2Premature rupture of membranes (HP:0001788)5.61247507
3Shallow orbits (HP:0000586)4.16565220
4Aortic dissection (HP:0002647)4.02432643
5Aortic aneurysm (HP:0004942)3.92255718
6Follicular hyperkeratosis (HP:0007502)3.91635691
7Menorrhagia (HP:0000132)3.86418825
8Cerebral aneurysm (HP:0004944)3.70365441
9Atrophic scars (HP:0001075)3.43062988
10Broad metatarsal (HP:0001783)3.41295623
11Dilatation of the ascending aorta (HP:0005111)3.22264464
12Ankle contracture (HP:0006466)3.19915496
13Short 4th metacarpal (HP:0010044)3.15271683
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15271683
15Peritonitis (HP:0002586)3.09427613
16Increased density of long bones (HP:0006392)3.06095953
17Soft skin (HP:0000977)3.01968193
18Cervical subluxation (HP:0003308)2.96558757
19Bladder diverticulum (HP:0000015)2.95737216
20Fragile skin (HP:0001030)2.89726712
21Increased mean platelet volume (HP:0011877)2.83291693
22Mitral valve prolapse (HP:0001634)2.83007578
23Asymmetry of the thorax (HP:0001555)2.78096315
24Wormian bones (HP:0002645)2.76580969
25Blue sclerae (HP:0000592)2.69743813
26Wrist flexion contracture (HP:0001239)2.62984203
27Hypoventilation (HP:0002791)2.60858449
28Camptodactyly of toe (HP:0001836)2.60817522
29Vascular tortuosity (HP:0004948)2.59702454
30Syringomyelia (HP:0003396)2.56700332
31Spinal cord lesions (HP:0100561)2.56700332
32Abnormal platelet volume (HP:0011876)2.56570704
33Broad ribs (HP:0000885)2.56104276
34Bowel diverticulosis (HP:0005222)2.55422549
35Genu recurvatum (HP:0002816)2.53719121
36Abnormality of dentin (HP:0010299)2.53287732
37Increased connective tissue (HP:0009025)2.50400787
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.47626032
39Osteolytic defects of the hand bones (HP:0009699)2.47626032
40Slender build (HP:0001533)2.46901071
41Abnormality of the 4th metacarpal (HP:0010012)2.45508255
42Aneurysm (HP:0002617)2.44482914
43Aortic valve stenosis (HP:0001650)2.39233477
44Anterior segment dysgenesis (HP:0007700)2.38342206
45Deviation of the hallux (HP:0010051)2.37339707
46Increased corneal curvature (HP:0100692)2.36923272
47Keratoconus (HP:0000563)2.36923272
48Spinal rigidity (HP:0003306)2.36870972
49Type 1 muscle fiber predominance (HP:0003803)2.35307404
50Prolonged bleeding time (HP:0003010)2.34821496
51Hydroureter (HP:0000072)2.32597869
52Hypoplasia of the iris (HP:0007676)2.30503712
53Hallux valgus (HP:0001822)2.30255401
54Subacute progressive viral hepatitis (HP:0006572)2.28629231
55Arterial tortuosity (HP:0005116)2.28347947
56Hematochezia (HP:0002573)2.24438601
57Neonatal short-limb short stature (HP:0008921)2.23473218
58Mesomelia (HP:0003027)2.19968946
59Vertebral compression fractures (HP:0002953)2.18443432
60Abnormality of the peritoneum (HP:0002585)2.18180113
61Wide anterior fontanel (HP:0000260)2.16867837
62Radial bowing (HP:0002986)2.16853632
63Increased variability in muscle fiber diameter (HP:0003557)2.15121945
64Spondylolisthesis (HP:0003302)2.12321861
65Nonimmune hydrops fetalis (HP:0001790)2.12312681
66Biconcave vertebral bodies (HP:0004586)2.11117480
67Protruding ear (HP:0000411)2.10408551
68Short nail (HP:0001799)2.08305346
69Joint contractures involving the joints of the feet (HP:0100492)2.07335517
70Flexion contracture of toe (HP:0005830)2.07335517
71Abnormality of the acetabulum (HP:0003170)2.06658358
72Thin bony cortex (HP:0002753)2.06545528
73Coronal craniosynostosis (HP:0004440)2.06243447
74Lymphangioma (HP:0100764)2.05705091
75Overgrowth (HP:0001548)2.03064583
76Mitral regurgitation (HP:0001653)2.01914675
77Persistence of primary teeth (HP:0006335)2.01531509
78Buphthalmos (HP:0000557)1.98478302
79Rectal prolapse (HP:0002035)1.97755803
80Disproportionate tall stature (HP:0001519)1.96626880
81Selective tooth agenesis (HP:0001592)1.96422540
82Joint laxity (HP:0001388)1.96370249
83Pulmonary artery stenosis (HP:0004415)1.95642824
84Spontaneous hematomas (HP:0007420)1.95214838
85Renal duplication (HP:0000075)1.92197732
86Inguinal hernia (HP:0000023)1.90849679
87Bicuspid aortic valve (HP:0001647)1.90434716
88Premature skin wrinkling (HP:0100678)1.90150936
89Adactyly (HP:0009776)1.89102381
90Mildly elevated creatine phosphokinase (HP:0008180)1.88582966
91Coxa vara (HP:0002812)1.88267279
92Aortic regurgitation (HP:0001659)1.88146543
93Conjunctival telangiectasia (HP:0000524)1.88123296
94Abnormal platelet function (HP:0011869)1.87890440
95Impaired platelet aggregation (HP:0003540)1.87890440
96Ectopia lentis (HP:0001083)1.86140394
97Bowed forearm bones (HP:0003956)1.84774019
98Bowing of the arm (HP:0006488)1.84774019
99Ulnar bowing (HP:0003031)1.82568002
100Abnormal delivery (HP:0001787)1.80916279
101Deviation of the thumb (HP:0009603)1.80675782
102Long toe (HP:0010511)1.79729969
103Abnormality of skeletal muscle fiber size (HP:0012084)1.78701546
104Short hallux (HP:0010109)1.78407984
105Chondrocalcinosis (HP:0000934)1.77525447
106Broad toe (HP:0001837)1.76931752
107Hyperextensible skin (HP:0000974)1.76193626
108Broad long bones (HP:0005622)1.75899356
109Enlarged penis (HP:0000040)1.75306170
110Venous abnormality (HP:0002624)1.75267620
111Tarsal synostosis (HP:0008368)1.73484159
112Dislocated radial head (HP:0003083)1.72726624
113Osteopenia (HP:0000938)1.72410292
114Right ventricular cardiomyopathy (HP:0011663)1.71718719
115Mesangial abnormality (HP:0001966)1.70454387
116Abnormality of the anterior chamber (HP:0000593)1.70363819
117Venous insufficiency (HP:0005293)1.70237918
118Mild short stature (HP:0003502)1.69782076
119Abnormality of the radial head (HP:0003995)1.69417056
120Limited hip movement (HP:0008800)1.69361939
121Tibial bowing (HP:0002982)1.68923617
122Abnormality of the calcaneus (HP:0008364)1.68293582
123Elbow flexion contracture (HP:0002987)1.67153090
124Broad hallux (HP:0010055)1.65805123
125Pulmonic stenosis (HP:0001642)1.65694909
126Polycythemia (HP:0001901)1.65626263
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.65538598
128Occipital encephalocele (HP:0002085)1.65147055
129Broad palm (HP:0001169)1.64481077
130Knee flexion contracture (HP:0006380)1.64178931
131Vertebral arch anomaly (HP:0008438)1.64163568
132Scapular winging (HP:0003691)1.63681688
133Joint stiffness (HP:0001387)1.63606920
134Delayed cranial suture closure (HP:0000270)1.62424297
135Absent frontal sinuses (HP:0002688)1.62398157
136Striae distensae (HP:0001065)1.62297821
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.62278882
138Broad face (HP:0000283)1.62177570
139Abnormality of skull ossification (HP:0002703)1.61490402
140Hip contracture (HP:0003273)1.60010041
141Upper limb amyotrophy (HP:0009129)1.58663247
142Distal upper limb amyotrophy (HP:0007149)1.58663247
143Vitreoretinal degeneration (HP:0000655)1.58068695
144Decreased skull ossification (HP:0004331)1.58037560
145Limb-girdle muscle weakness (HP:0003325)1.56278467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.53854407
2TIE13.37203646
3NTRK13.31866992
4TTN3.22365181
5EPHB23.05635681
6TRIB32.99678122
7PDGFRA2.70210774
8PKN22.64310811
9LATS12.60757776
10TGFBR12.36438788
11TGFBR22.27374097
12LRRK22.20650563
13STK102.06949232
14EEF2K2.05379162
15DDR21.90724617
16STK31.87521798
17PAK41.83980062
18PAK21.82941837
19ERBB41.80468385
20PTK61.78115217
21LATS21.73504023
22RIPK11.64853466
23PTK21.63589269
24BCR1.63485472
25DMPK1.56061657
26TRPM71.50160900
27NEK91.45218305
28FGFR11.44949184
29CDK61.43588178
30ERN11.43185690
31FER1.31773434
32ADRBK11.29709422
33RPS6KA41.28505025
34LMTK21.27789426
35RPS6KB21.22757317
36ILK1.22506826
37SCYL21.20978968
38EPHA21.17596436
39PDGFRB1.16427313
40CDK121.15489666
41ADRBK21.13431725
42PLK21.13339285
43SIK11.13313419
44FGFR31.12326820
45MAP3K101.10989506
46PAK31.09526333
47MTOR1.08404305
48CSNK1A1L1.07502744
49EPHA31.06575973
50GRK51.02037905
51MAP2K31.01091589
52PNCK1.01038754
53BMX1.00868920
54TESK10.98962581
55MKNK10.98906778
56CSNK1G30.98059446
57ROCK10.95094250
58MYLK0.93286864
59PTK2B0.93136653
60PIK3CG0.92689556
61FGFR40.92404048
62NUAK10.91756638
63CSNK1G10.90938559
64MAP2K70.89742786
65LIMK10.89429553
66BRSK20.88240894
67GRK70.85337898
68MARK10.85303707
69PIM20.85284110
70GRK10.82821183
71KIT0.81849455
72MAP3K80.81127444
73PIK3CA0.80627187
74FGFR20.79661920
75PRKCE0.76889447
76PRKD20.75562172
77NEK20.73607355
78ERBB30.73003000
79CSNK1G20.72020955
80MAP3K30.67768158
81STK240.67422876
82FRK0.65532225
83MOS0.64722503
84PRKG20.63943086
85TESK20.62864745
86CDC70.62606493
87ROCK20.61670683
88MAPKAPK50.60963124
89JAK30.60023652
90DAPK30.59205416
91TEC0.57321996
92MAPKAPK30.56568761
93DYRK20.54564154
94CDK70.53981685
95CDK140.52910973
96AURKB0.52854414
97ITK0.51177334
98SRPK10.50751261
99MAPKAPK20.50232784
100PAK60.49663936
101DYRK1B0.49378159
102FLT30.49006845
103MATK0.47576921
104RET0.47234442
105INSR0.47214302
106DYRK30.47050390
107ERBB20.46643066
108ZAP700.46591774
109AKT30.45534408
110CDK40.45041912
111MELK0.45008433
112ZAK0.44007583
113CDK80.43811693
114STK38L0.43782107
115RPS6KA20.43475887
116ABL20.43216553
117MET0.42909392
118IGF1R0.42219688
119CHUK0.41716822
120PLK30.41664968
121NEK10.41649768
122PRKD10.41620223
123MAP2K10.40216779
124PAK10.40103184
125TYRO30.38770225
126SRC0.37065976
127EPHA40.36502113
128TXK0.36029657
129TAOK20.36020513
130EPHB10.35217221
131GSK3A0.32398023
132CDK180.32203842
133PIM10.31073740
134MAP3K60.30717020
135JAK10.30447371
136EGFR0.30044852
137CDK150.29485003
138CASK0.29338474
139TNIK0.29280840
140MAP3K40.27939582
141BCKDK0.26817583
142MAPK70.26768800
143CDK11A0.26489636
144KSR10.25938050
145STK380.24500223

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.75014982
2Focal adhesion_Homo sapiens_hsa045102.86344847
3Small cell lung cancer_Homo sapiens_hsa052222.68845125
4Adherens junction_Homo sapiens_hsa045202.48035830
5Proteoglycans in cancer_Homo sapiens_hsa052052.24942411
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.21655469
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.18804611
8TGF-beta signaling pathway_Homo sapiens_hsa043502.17177185
9MicroRNAs in cancer_Homo sapiens_hsa052062.10904378
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.09643259
11Hippo signaling pathway_Homo sapiens_hsa043902.01711279
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.01156735
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98367697
14Chronic myeloid leukemia_Homo sapiens_hsa052201.94459929
15Bladder cancer_Homo sapiens_hsa052191.89863385
16Dilated cardiomyopathy_Homo sapiens_hsa054141.87361371
17Viral myocarditis_Homo sapiens_hsa054161.78138293
18p53 signaling pathway_Homo sapiens_hsa041151.76389391
19Amoebiasis_Homo sapiens_hsa051461.72361809
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.66962431
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59255680
22Basal cell carcinoma_Homo sapiens_hsa052171.58795487
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.57534706
24Cell cycle_Homo sapiens_hsa041101.51298131
25* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.51115422
26* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.50927178
27Steroid biosynthesis_Homo sapiens_hsa001001.50023110
28* Platelet activation_Homo sapiens_hsa046111.45330686
29Pancreatic cancer_Homo sapiens_hsa052121.42930478
30Shigellosis_Homo sapiens_hsa051311.41202272
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41192675
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39197032
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38479221
34Toxoplasmosis_Homo sapiens_hsa051451.36564603
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35875762
36* Pathways in cancer_Homo sapiens_hsa052001.33041826
37Colorectal cancer_Homo sapiens_hsa052101.32398981
38Malaria_Homo sapiens_hsa051441.32187721
39HTLV-I infection_Homo sapiens_hsa051661.31015440
40Notch signaling pathway_Homo sapiens_hsa043301.29253652
41* Rap1 signaling pathway_Homo sapiens_hsa040151.23269977
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22983834
43Protein digestion and absorption_Homo sapiens_hsa049741.21542775
44Thyroid cancer_Homo sapiens_hsa052161.21084776
45Viral carcinogenesis_Homo sapiens_hsa052031.18064800
46Melanoma_Homo sapiens_hsa052181.16300325
47Renin-angiotensin system_Homo sapiens_hsa046141.15529802
48Prostate cancer_Homo sapiens_hsa052151.14005234
49Hedgehog signaling pathway_Homo sapiens_hsa043401.11372255
50Hematopoietic cell lineage_Homo sapiens_hsa046401.05894879
51Protein export_Homo sapiens_hsa030601.03895979
52Tight junction_Homo sapiens_hsa045301.03456540
53Hepatitis B_Homo sapiens_hsa051611.02600076
54Endometrial cancer_Homo sapiens_hsa052130.98070897
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.93285708
56Apoptosis_Homo sapiens_hsa042100.92876453
57TNF signaling pathway_Homo sapiens_hsa046680.92737005
58Axon guidance_Homo sapiens_hsa043600.92689648
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92089871
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88340911
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87580322
62Wnt signaling pathway_Homo sapiens_hsa043100.87167246
63Renal cell carcinoma_Homo sapiens_hsa052110.84770782
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.84603453
65Glioma_Homo sapiens_hsa052140.84600908
66Vibrio cholerae infection_Homo sapiens_hsa051100.79566728
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75664659
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74864156
69Non-small cell lung cancer_Homo sapiens_hsa052230.74162289
70FoxO signaling pathway_Homo sapiens_hsa040680.73854972
71HIF-1 signaling pathway_Homo sapiens_hsa040660.71583597
72Leishmaniasis_Homo sapiens_hsa051400.69137240
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67961992
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66407325
75Salmonella infection_Homo sapiens_hsa051320.66039152
76Acute myeloid leukemia_Homo sapiens_hsa052210.65399941
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63882656
78VEGF signaling pathway_Homo sapiens_hsa043700.63704183
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.61932947
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.61929915
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61705811
82Fatty acid elongation_Homo sapiens_hsa000620.61233072
83Sulfur metabolism_Homo sapiens_hsa009200.59645588
84One carbon pool by folate_Homo sapiens_hsa006700.59479679
85Lysine degradation_Homo sapiens_hsa003100.59456150
86Cocaine addiction_Homo sapiens_hsa050300.59091218
87RNA transport_Homo sapiens_hsa030130.58986928
88Sulfur relay system_Homo sapiens_hsa041220.58032933
89Long-term depression_Homo sapiens_hsa047300.57453306
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56553843
91* Phospholipase D signaling pathway_Homo sapiens_hsa040720.56058805
92N-Glycan biosynthesis_Homo sapiens_hsa005100.54888906
93Ovarian steroidogenesis_Homo sapiens_hsa049130.54815228
94Antigen processing and presentation_Homo sapiens_hsa046120.54614214
95Measles_Homo sapiens_hsa051620.54171734
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52986596
97Melanogenesis_Homo sapiens_hsa049160.50662471
98Gap junction_Homo sapiens_hsa045400.50025002
99mTOR signaling pathway_Homo sapiens_hsa041500.49368407
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49253997
101* Complement and coagulation cascades_Homo sapiens_hsa046100.48278442
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47637302
103Choline metabolism in cancer_Homo sapiens_hsa052310.47444398
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47279177
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46918014
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46910336
107Serotonergic synapse_Homo sapiens_hsa047260.46624477
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46072920
109Insulin resistance_Homo sapiens_hsa049310.44772357
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44004175
111Systemic lupus erythematosus_Homo sapiens_hsa053220.42842980
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42592999
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41895831
114Phagosome_Homo sapiens_hsa041450.41859355
115DNA replication_Homo sapiens_hsa030300.40645488
116Osteoclast differentiation_Homo sapiens_hsa043800.39991002
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39163592
118ErbB signaling pathway_Homo sapiens_hsa040120.38001631
119Spliceosome_Homo sapiens_hsa030400.37767402
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37691231
121Thyroid hormone synthesis_Homo sapiens_hsa049180.37395923
122Ras signaling pathway_Homo sapiens_hsa040140.37363084
123* Endocytosis_Homo sapiens_hsa041440.37293763
124Prolactin signaling pathway_Homo sapiens_hsa049170.37183356
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36685235
126Epstein-Barr virus infection_Homo sapiens_hsa051690.36453843
127Estrogen signaling pathway_Homo sapiens_hsa049150.35268989
128Dorso-ventral axis formation_Homo sapiens_hsa043200.34125700
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33943940
130T cell receptor signaling pathway_Homo sapiens_hsa046600.32940029
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32601971
132Selenocompound metabolism_Homo sapiens_hsa004500.29543286
133Arachidonic acid metabolism_Homo sapiens_hsa005900.27540381
134Prion diseases_Homo sapiens_hsa050200.24511302
135Alcoholism_Homo sapiens_hsa050340.23789437
136* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22682104
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22551838
138Cholinergic synapse_Homo sapiens_hsa047250.21793600
139GABAergic synapse_Homo sapiens_hsa047270.19136444

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